DE10299042I2 - Verwendung von Tetrahydrocarbazolderivaten als 5HT1-Rezeptor-agonisten. - Google Patents

Verwendung von Tetrahydrocarbazolderivaten als 5HT1-Rezeptor-agonisten.

Info

Publication number: DE10299042I2
Authority: DE; Germany
Prior art keywords: receptor agonists; tetrahydrocarbazole derivatives; tetrahydrocarbazole; derivatives; agonists
Prior art date: 1991-06-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

DE2002199042

Other languages

English (en)

Other versions

DE10299042I1 (de

Inventor

Francis David Smithkline King

Laramie Mary Smithkline Gaster

Alberto Julio C O Smit Kaumann

Rodney Christopher C O S Young

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Ltd

Original Assignee

SmithKline Beecham Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-26

Filing date

1992-06-17

Publication date

2005-02-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10299042(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-06-17 Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd

2003-02-20 Application granted granted Critical

2003-02-20 Publication of DE10299042I1 publication Critical patent/DE10299042I1/de

2005-02-03 Publication of DE10299042I2 publication Critical patent/DE10299042I2/de

Status Active legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE2002199042 1991-06-26 1992-06-17 Verwendung von Tetrahydrocarbazolderivaten als 5HT1-Rezeptor-agonisten. Active DE10299042I2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919113802A GB9113802D0 (en)	1991-06-26	1991-06-26	Medicaments
PCT/GB1992/001082 WO1993000086A1 (en)	1991-06-26	1992-06-17	Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists

Publications (2)

Publication Number	Publication Date
DE10299042I1 DE10299042I1 (de)	2003-02-20
DE10299042I2 true DE10299042I2 (de)	2005-02-03

Family

ID=10697363

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69226953T Expired - Lifetime DE69226953T2 (de)	1991-06-26	1992-06-17	Verwendung von tetrahydrocarbazolderivaten als 5ht1-rezeptor-agonisten
DE2002199042 Active DE10299042I2 (de)	1991-06-26	1992-06-17	Verwendung von Tetrahydrocarbazolderivaten als 5HT1-Rezeptor-agonisten.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69226953T Expired - Lifetime DE69226953T2 (de)	1991-06-26	1992-06-17	Verwendung von tetrahydrocarbazolderivaten als 5ht1-rezeptor-agonisten

Country Status (34)

Country	Link
US (2)	US5464864A (de)
EP (1)	EP0591280B1 (de)
JP (1)	JP3261502B2 (de)
KR (1)	KR100251571B1 (de)
CN (1)	CN1034072C (de)
AP (1)	AP344A (de)
AT (1)	ATE170746T1 (de)
BR (2)	BR9206237A (de)
CA (1)	CA2113726C (de)
CZ (3)	CZ282327B6 (de)
DE (2)	DE69226953T2 (de)
DK (1)	DK0591280T3 (de)
FI (1)	FI103967B (de)
GB (1)	GB9113802D0 (de)
HU (1)	HU218907B (de)
IE (1)	IE922062A1 (de)
IL (4)	IL117105A0 (de)
LU (1)	LU90939I2 (de)
MA (1)	MA22563A1 (de)
MX (1)	MX9203444A (de)
NL (1)	NL300103I2 (de)
NO (2)	NO304774B1 (de)
NZ (1)	NZ243288A (de)
PL (3)	PL169392B1 (de)
PT (1)	PT100620B (de)
RU (1)	RU2137474C1 (de)
SA (1)	SA92130141B1 (de)
SG (1)	SG47877A1 (de)
SI (1)	SI9200125B (de)
SK (3)	SK280907B6 (de)
TW (1)	TW214544B (de)
UA (1)	UA41254C2 (de)
WO (1)	WO1993000086A1 (de)
ZA (1)	ZA924658B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9211277D0 (en)	1992-05-28	1992-07-15	Glaxo Group Inc	Pharmaceutical compositions
GB9226530D0 (en) *	1992-12-21	1993-02-17	Smithkline Beecham Plc	Compounds
GB9226566D0 (en) *	1992-12-21	1993-02-17	Smithkline Beecham Plc	Compounds
US5616603A (en) *	1995-05-26	1997-04-01	Smithkline Beecham Plc	Enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5618948A (en) *	1995-05-26	1997-04-08	Smithkline Beecham P.L.C.	Process for preparing an enantiomer of a carbazole derivative
DE69610793T2 (de) *	1995-06-23	2001-05-03	Eli Lilly And Co., Indianapolis	6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
US5917054A (en) *	1995-07-18	1999-06-29	Smithkline Beecham P.L.C.	Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) *	1996-06-27	1998-01-13	Eli Lilly And Company	6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) *	1996-10-09	1999-04-06	Algos Pharmaceutical Corporation	Method for treating migraine
GB9723061D0 (en) *	1997-10-31	1998-01-07	Vanguard Medica Ltd	Medicaments
US6066092A (en) *	1997-11-06	2000-05-23	Cady; Roger K.	Preemptive prophylaxis of migraine device and method
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
GB9808069D0 (en) *	1998-04-16	1998-06-17	Vanguard Medica Ltd	Novel processes
GB9817911D0 (en) *	1998-08-17	1998-10-14	Vanguard Medica Ltd	New use
US6685951B2 (en)	2001-07-05	2004-02-03	R. T. Alamo Ventures I, Inc.	Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) *	2001-07-05	2003-10-23	R.T. Alamo Ventures I, Llc	Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) *	2001-07-05	2003-01-23	R.T. Alamo Ventures I, Inc.	Sublingual administration of dihydroergotamine for the treatment of migraine
WO2003029214A1 (en) *	2001-09-28	2003-04-10	F. Hoffmann-La Roche Ag	Pseudopolymorphic forms of carvedilol
AU2003249584B9 (en)	2002-06-21	2008-05-15	Suven Life Sciences Limited	Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
CA2490254C (en)	2002-06-21	2011-11-01	Suven Life Sciences Limited	Novel tetracyclic arylsulfonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
DK1581492T3 (da)	2002-11-28	2008-11-10	Suven Life Sciences Ltd	N-arylsulfonyl-3-substituerede indoler med serotoninreceptoraffinitet, fremgangsmåde til fremstilling heraf og en farmaceutisk sammensætning indeholdende disse
PT1567492E (pt)	2002-11-28	2013-07-22	Suven Life Sciences Ltd	N-arilsulfonil-3-aminoalcoxi-indóis
NZ540841A (en)	2002-12-18	2008-08-29	Suven Life Sciences Ltd	Tetracyclic 3-substituted indoles having serotonin receptor affinity
RU2430088C2 (ru) *	2004-07-14	2011-09-27	Центарис Гмбх	Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en)	2006-07-27	2009-10-13	Wyeth	Benzofurans as potassium ion channel modulators
NZ574705A (en) *	2006-08-07	2011-12-22	Actelion Pharmaceuticals Ltd	(3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
EP2813144A1 (de)	2006-10-09	2014-12-17	Charleston Laboratories, Inc.	Analgetische Zusammensetzungen enthaltend ein Antihistamin
PT2425820E (pt)	2007-02-11	2015-08-04	Map Pharmaceuticals Inc	Método de administração terapêutica de dhe para permitir o rápido alívio das enxaquecas ao mesmo tempo que minimiza o perfil de efeitos secundários
US20090069399A1 (en) *	2007-09-12	2009-03-12	Protia, Llc	Deuterium-enriched frovatriptan
JP5714910B2 (ja)	2008-01-09	2015-05-07	チャールストンラボラトリーズ，インコーポレイテッド	薬学的組成物
WO2010073253A1 (en) *	2008-12-22	2010-07-01	Natco Pharma Limited	Method for preparing an optically active frovatriptan
EP2451274B1 (de)	2009-07-08	2017-10-04	Charleston Laboratories, Inc.	Pharmazeutische zusammensetzungen
US9204906B2 (en)	2009-10-22	2015-12-08	Nuvasive, Inc.	Posterior cervical fusion system and techniques
US10098674B2 (en)	2009-10-22	2018-10-16	Nuvasive, Inc.	System and method for posterior cervical fusion
WO2013016223A2 (en)	2011-07-22	2013-01-31	The University Of Chicago	Treatments for migraine and related disorders
CA2895816C (en)	2012-12-21	2021-02-23	Map Pharmaceuticals, Inc.	8'-hydroxy-dihydroergotamine compounds and compositions
EP2816030A1 (de)	2013-06-20	2014-12-24	Duke Chem, S. A.	Verfahren zur Herstellung von Frovatriptan und dessen Enantiomer
GB201312768D0 (en) *	2013-07-17	2013-08-28	Ge Healthcare Ltd	Work-up procedure
US10179109B2 (en)	2016-03-04	2019-01-15	Charleston Laboratories, Inc.	Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
EP3766483A1 (de)	2019-07-19	2021-01-20	BioPharma Synergies, S. L.	Orodispergierbare pulverzusammensetzung mit einem triptan
WO2025038666A2 (en) *	2023-08-13	2025-02-20	GATC Health Corp	Compounds and methods for treating addiction
CN119499195A (zh) *	2024-11-26	2025-02-25	青岛国信制药有限公司	一种快速吸收琥珀酸呋罗曲坦片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3642816A (en) *	1967-08-10	1972-02-15	Sterling Drug Inc	3-acetamido-1 2 3 4-tetrahydrocarbazole
US3959309A (en) *	1968-01-24	1976-05-25	Sterling Drug Inc.	3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) *	1968-01-24	1977-12-13	Sterling Drug Inc.	3-Hydroxy carbazole derivatives
US3592824A (en) *	1970-03-12	1971-07-13	Miles Lab	3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en)	1971-08-16	1979-10-30	Sterling Drug Inc.	3-Amino-tetrahydrocarbazoles
BE787537A (fr) *	1971-08-16	1973-02-14	Sterling Drug Inc	Tetrahydrocarbazoles
DE2815926A1 (de) *	1978-04-13	1979-10-18	Boehringer Mannheim Gmbh	Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4257952A (en) *	1977-06-06	1981-03-24	Sterling Drug Inc.	3-Amino-tetrahydrocarbazoles
US4254134A (en) *	1978-03-17	1981-03-03	Endo Laboratories, Inc.	Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) *	1983-01-04	1984-08-15	MERCK PATENT GmbH	Tetrahydrocarbazolderivate

1991
- 1991-06-26 GB GB919113802A patent/GB9113802D0/en active Pending
1992
- 1992-06-17 CZ CZ961506A patent/CZ282327B6/cs not_active IP Right Cessation
- 1992-06-17 DE DE69226953T patent/DE69226953T2/de not_active Expired - Lifetime
- 1992-06-17 CZ CS932861A patent/CZ282083B6/cs not_active IP Right Cessation
- 1992-06-17 SK SK1685-98A patent/SK280907B6/sk not_active IP Right Cessation
- 1992-06-17 RU RU93058534A patent/RU2137474C1/ru active Protection Beyond IP Right Term
- 1992-06-17 JP JP51108692A patent/JP3261502B2/ja not_active Expired - Lifetime
- 1992-06-17 BR BR9206237A patent/BR9206237A/pt not_active Application Discontinuation
- 1992-06-17 EP EP92912379A patent/EP0591280B1/de not_active Expired - Lifetime
- 1992-06-17 DE DE2002199042 patent/DE10299042I2/de active Active
- 1992-06-17 HU HU9303731A patent/HU218907B/hu active IP Right Revival
- 1992-06-17 PL PL92301883A patent/PL169392B1/pl unknown
- 1992-06-17 SK SK1054-98A patent/SK280906B6/sk not_active IP Right Cessation
- 1992-06-17 AT AT92912379T patent/ATE170746T1/de active
- 1992-06-17 PL PL92307118A patent/PL169410B1/pl unknown
- 1992-06-17 SK SK1319-93A patent/SK280905B6/sk not_active IP Right Cessation
- 1992-06-17 UA UA93002251A patent/UA41254C2/uk unknown
- 1992-06-17 SG SG1996004938A patent/SG47877A1/en unknown
- 1992-06-17 US US08/167,846 patent/US5464864A/en not_active Expired - Lifetime
- 1992-06-17 CA CA002113726A patent/CA2113726C/en not_active Expired - Lifetime
- 1992-06-17 DK DK92912379T patent/DK0591280T3/da active
- 1992-06-17 WO PCT/GB1992/001082 patent/WO1993000086A1/en not_active Ceased
- 1992-06-17 KR KR1019930704055A patent/KR100251571B1/ko not_active Expired - Lifetime
- 1992-06-17 CZ CZ961505A patent/CZ150596A3/cs not_active IP Right Cessation
- 1992-06-17 PL PL92311304A patent/PL171034B1/pl unknown
- 1992-06-24 PT PT100620A patent/PT100620B/pt not_active IP Right Cessation
- 1992-06-24 ZA ZA924658A patent/ZA924658B/xx unknown
- 1992-06-24 MA MA22853A patent/MA22563A1/fr unknown
- 1992-06-24 NZ NZ243288A patent/NZ243288A/en not_active IP Right Cessation
- 1992-06-25 IL IL11710596A patent/IL117105A0/xx unknown
- 1992-06-25 IL IL102322A patent/IL102322A/xx not_active IP Right Cessation
- 1992-06-25 CN CN92108831A patent/CN1034072C/zh not_active Expired - Lifetime
- 1992-06-25 AP APAP/P/1992/000403A patent/AP344A/en active
- 1992-06-25 IL IL117105A patent/IL117105A/en not_active IP Right Cessation
- 1992-06-25 TW TW081104991A patent/TW214544B/zh not_active IP Right Cessation
- 1992-06-25 IL IL117104A patent/IL117104A/xx not_active IP Right Cessation
- 1992-06-26 MX MX9203444A patent/MX9203444A/es unknown
- 1992-06-26 SI SI9200125A patent/SI9200125B/sl unknown
- 1992-07-01 IE IE206292A patent/IE922062A1/en not_active IP Right Cessation
- 1992-10-04 SA SA92130141A patent/SA92130141B1/ar unknown
1993
- 1993-12-23 NO NO934759A patent/NO304774B1/no not_active IP Right Cessation
- 1993-12-23 FI FI935842A patent/FI103967B/fi not_active IP Right Cessation
1995
- 1995-05-15 US US08/442,719 patent/US5637611A/en not_active Expired - Lifetime
1997
- 1997-05-06 BR BR1100460-6A patent/BR1100460A/pt active IP Right Grant
2002
- 2002-07-24 LU LU90939C patent/LU90939I2/fr unknown
- 2002-10-14 NL NL300103C patent/NL300103I2/nl unknown
2005
- 2005-05-03 NO NO2005011C patent/NO2005011I2/no unknown

Also Published As

Publication number	Publication date
CZ150696A3 (en)	1997-06-11
AU1977592A (en)	1993-01-25
MA22563A1 (fr)	1992-12-31
WO1993000086A1 (en)	1993-01-07
UA41254C2 (uk)	2001-09-17
IL117104A0 (en)	1996-06-18
GB9113802D0 (en)	1991-08-14
ATE170746T1 (de)	1998-09-15
SG47877A1 (en)	1998-04-17
IL117105A0 (en)	1996-06-18
IL117105A (en)	1998-01-04
NL300103I1 (nl)	2002-12-02
SK131993A3 (en)	1994-06-08
SI9200125B (en)	2001-12-31
IL117104A (en)	1997-09-30
US5637611A (en)	1997-06-10
KR100251571B1 (ko)	2000-07-01
US5464864A (en)	1995-11-07
DE69226953T2 (de)	1999-05-12
CN1069726A (zh)	1993-03-10
ZA924658B (en)	1993-12-24
SK280907B6 (sk)	2000-09-12
EP0591280B1 (de)	1998-09-09
TW214544B (de)	1993-10-11
CN1034072C (zh)	1997-02-19
CA2113726C (en)	2008-02-19
BR9206237A (pt)	1995-04-11
CZ282083B6 (cs)	1997-05-14
FI935842A0 (fi)	1993-12-23
MX9203444A (es)	1993-12-01
AU652842B2 (en)	1994-09-08
NO2005011I1 (no)	2005-05-18
PT100620B (pt)	1999-01-29
AP9200403A0 (en)	1992-07-31
PL169392B1 (pl)	1996-07-31
CZ282327B6 (cs)	1997-06-11
NO304774B1 (no)	1999-02-15
RU2137474C1 (ru)	1999-09-20
SK280906B6 (sk)	2000-09-12
SI9200125A (en)	1992-12-31
SA92130141B1 (ar)	2005-12-18
FI935842A7 (fi)	1993-12-23
IL102322A (en)	1997-09-30
EP0591280A1 (de)	1994-04-13
HK1014669A1 (en)	1999-09-30
DE10299042I1 (de)	2003-02-20
JPH06508827A (ja)	1994-10-06
SK280905B6 (sk)	2000-09-12
FI103967B1 (fi)	1999-10-29
PT100620A (pt)	1993-09-30
LU90939I2 (fr)	2002-09-24
NZ243288A (en)	1994-09-27
CZ282061B6 (cs)	1997-05-14
CZ150596A3 (en)	1997-05-14
PL169410B1 (pl)	1996-07-31
PL171034B1 (en)	1997-02-28
HU218907B (hu)	2000-12-28
CZ286193A3 (en)	1994-07-13
DK0591280T3 (da)	1999-02-15
NO934800D0 (no)	1993-12-23
IE922062A1 (en)	1992-12-30
NO2005011I2 (no)	2008-02-11
IL102322A0 (en)	1993-01-14
NO934800L (no)	1993-12-23
HUT68961A (en)	1995-08-28
CA2113726A1 (en)	1993-01-07
BR1100460A (pt)	2000-07-18
NL300103I2 (nl)	2003-02-03
AP344A (en)	1994-07-05
DE69226953D1 (de)	1998-10-15
FI103967B (fi)	1999-10-29
JP3261502B2 (ja)	2002-03-04

Publication	Publication Date	Title
DE10299042I2 (de)	2005-02-03	Verwendung von Tetrahydrocarbazolderivaten als 5HT1-Rezeptor-agonisten.
DE69127791D1 (de)	1997-11-06	Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten
FI914065A7 (fi)	1992-03-01	Serotoniini-5HT1A-agonisteja
KR950700906A (ko)	1995-02-20	5-ht1 작동약으로서의 인돌 유도체(indole derivatives as 5-ht1 agonists)
DE68913022D1 (de)	1994-03-24	Heterozyklische Derivate.
DE69325167D1 (de)	1999-07-08	Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten
FI944805A7 (fi)	1994-10-12	Indolijohdannaisia 5-HT1-kaltaisina agonisteina
FI915920L (fi)	1992-06-19	Serotoninantagonister.
DE69401823D1 (de)	1997-04-03	Indolin derivate als 5ht2c antagonisten
FI961628A0 (fi)	1996-04-12	Indolijohdannaisia NMDA-antagonisteina
ATE222492T1 (de)	2002-09-15	Verwendung von indolderivaten als 5ht1-agonisten
DE69418045D1 (de)	1999-05-27	Amidderivate als 5ht1d rezeptor antagonisten
DE69617995D1 (de)	2002-01-24	Indolalkylderivate von benzodioxanmenthylamin als 5-ht1a rezeptor liganden
DE59006366D1 (de)	1994-08-11	Substituierte Pyrazolinderivate.
DE69003213D1 (de)	1993-10-14	Imidazol-Derivate als Histamin-H3-Agonisten.
DE59007918D1 (de)	1995-01-19	4-Alkoxy- bzw. 4-(substituierte)Amino-3-arylpyrrolinon-Derivate.
DE69320653D1 (de)	1998-10-01	Tetrahydrocarbazolderivate als 5-ht1-ähnliche agonisten
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FI912963A0 (fi)	1991-06-18	Hjaernverksamheten oekande pyrimidinylderivat.
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