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DE10230692A1 - Verfahren und Nukleinsäuren für die Analyse von Methylierungsmustern innerhalb des DD3-Gens - Google Patents

Verfahren und Nukleinsäuren für die Analyse von Methylierungsmustern innerhalb des DD3-Gens Download PDF

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Publication number
DE10230692A1
DE10230692A1 DE10230692A DE10230692A DE10230692A1 DE 10230692 A1 DE10230692 A1 DE 10230692A1 DE 10230692 A DE10230692 A DE 10230692A DE 10230692 A DE10230692 A DE 10230692A DE 10230692 A1 DE10230692 A1 DE 10230692A1
Authority
DE
Germany
Prior art keywords
seq
dna
sequences
methylation
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10230692A
Other languages
German (de)
English (en)
Inventor
Torsten Dr. Horns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics AG filed Critical Epigenomics AG
Priority to DE10230692A priority Critical patent/DE10230692A1/de
Priority to EP03740336A priority patent/EP1527198A1/fr
Priority to AU2003281281A priority patent/AU2003281281A1/en
Priority to PCT/EP2003/006690 priority patent/WO2004005543A1/fr
Priority to US10/520,992 priority patent/US20060210976A1/en
Publication of DE10230692A1 publication Critical patent/DE10230692A1/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE10230692A 2002-07-08 2002-07-08 Verfahren und Nukleinsäuren für die Analyse von Methylierungsmustern innerhalb des DD3-Gens Withdrawn DE10230692A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE10230692A DE10230692A1 (de) 2002-07-08 2002-07-08 Verfahren und Nukleinsäuren für die Analyse von Methylierungsmustern innerhalb des DD3-Gens
EP03740336A EP1527198A1 (fr) 2002-07-08 2003-06-25 Procedes et acides nucleiques pour l'analyse de motifs de methylation dans le gene dd3
AU2003281281A AU2003281281A1 (en) 2002-07-08 2003-06-25 Methods and nucleic acids for the analysis of methylation patterns within the dd3 gene
PCT/EP2003/006690 WO2004005543A1 (fr) 2002-07-08 2003-06-25 Procedes et acides nucleiques pour l'analyse de motifs de methylation dans le gene dd3
US10/520,992 US20060210976A1 (en) 2002-07-08 2003-06-25 Methods and nucleic acids for the analysis of methylation patterns within the dd3 gene

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10230692A DE10230692A1 (de) 2002-07-08 2002-07-08 Verfahren und Nukleinsäuren für die Analyse von Methylierungsmustern innerhalb des DD3-Gens

Publications (1)

Publication Number Publication Date
DE10230692A1 true DE10230692A1 (de) 2004-02-12

Family

ID=30009836

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10230692A Withdrawn DE10230692A1 (de) 2002-07-08 2002-07-08 Verfahren und Nukleinsäuren für die Analyse von Methylierungsmustern innerhalb des DD3-Gens

Country Status (5)

Country Link
US (1) US20060210976A1 (fr)
EP (1) EP1527198A1 (fr)
AU (1) AU2003281281A1 (fr)
DE (1) DE10230692A1 (fr)
WO (1) WO2004005543A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005007185A1 (de) * 2005-02-16 2006-08-17 Epigenomics Ag Verfahren zur Herstellung einer Mischung von Fragmenten einer Polynukleinsäure
EP1693468A1 (fr) 2005-02-16 2006-08-23 Epigenomics AG Procédé de détection de l'état de méthylation d'un acide polynucléique
EP2481810A1 (fr) 2005-04-15 2012-08-01 Epigenomics AG Procédé pour fournir un dérivé d'échantillon à distance

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691965B2 (en) 2007-06-14 2014-04-08 Mirx Therapeutics Aps Oligonucleotides for modulating target RNA activity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648214A (en) * 1990-06-11 1997-07-15 University Research Corporation High-affinity oligonucleotide ligands to the tachykinin substance P

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1277025B1 (it) * 1995-12-04 1997-11-04 Cooperativa Centro Ricerche Po Classe di oligonucleotidi fosfodiesterici ad attivita' citotossica composizioni farmaceutiche che li contengono e loro uso
ES2402947T3 (es) * 1997-04-10 2013-05-10 Stichting Katholieke Universiteit University Medical Centre Nijmegen PCA3, genes PCA3 y métodos de uso
AUPP312998A0 (en) * 1998-04-23 1998-05-14 Commonwealth Scientific And Industrial Research Organisation Diagnostic assay
DE60027027T2 (de) * 1999-09-29 2006-11-30 Diagnocure Inc. Pca3 mrna in gutartigen und bösartigen prostatageweben
WO2001060860A2 (fr) * 2000-02-17 2001-08-23 Millennium Predictive Medicine, Inc. Genes, compositions, kits, et procedes d'identification, d'evaluation, de prevention, et de traitement du cancer de la prostate
WO2002024718A1 (fr) * 2000-09-19 2002-03-28 Diadexus, Inc. Compositions et methodes concernant des genes et des proteines specifiques de la prostate
JP2002360255A (ja) * 2001-05-31 2002-12-17 Univ Hospital Nijmegen ＰＣＡ３ｄｄ３、新規前立腺抗原のためのプロモーターを含む核酸分子、及びその使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648214A (en) * 1990-06-11 1997-07-15 University Research Corporation High-affinity oligonucleotide ligands to the tachykinin substance P

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
$_datasheet.pdf [rech. am 04.04.2003]
Datenbank Genbank, Eintragungsnummer AF279290 vom 04.12.2000 [rech. am 04.04.2003] *
Datenbank Genbank, Eintragungsnummer AL359314 vom 15.05.2001, Ausschnitt aus der ersten Seite [rech. am 04.04.2003];$
Datenbank SCISEARCH bei STN, AN 1999:404107 zu: Changes in gene expression and targets for therapy. BUSSEMAKES, M.J.G. (Reprint) EUROPEAN UROLOGY, (MAY-JUN 1999) 35(5-6) 408-412 [rech. am 04.04.2003] *
Internetdokument, copyright 2001, Adresse www. affymetrix.com/support/technical/datasheets/hgu133 *
KERJEAN, A. u.a.: Bisulfite genomic sequencing of microdissected cells. Nucleic Acids Res. (2001) 29(21)e106 *
KINOSHITA, H. u.a.: Methylation of the Androgen Receptor Minimal Promoter Silences Transcription in Human Prostate Cancer. Cancer Res. (2000)60, 3623-3630 *
VERHAEGH, G.W. u.a: Isolation and Characterization of the Promoter of the Human Prostate Cancer- specific DD3 Gene. J. Biol. Chem. (2000) 275(48) 37496-37503
VERHAEGH, G.W. u.a: Isolation and Characterizationof the Promoter of the Human Prostate Cancer- specific DD3 Gene. J. Biol. Chem. (2000) 275(48) 37496-37503 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005007185A1 (de) * 2005-02-16 2006-08-17 Epigenomics Ag Verfahren zur Herstellung einer Mischung von Fragmenten einer Polynukleinsäure
EP1693468A1 (fr) 2005-02-16 2006-08-23 Epigenomics AG Procédé de détection de l'état de méthylation d'un acide polynucléique
EP2481810A1 (fr) 2005-04-15 2012-08-01 Epigenomics AG Procédé pour fournir un dérivé d'échantillon à distance
US10731215B2 (en) 2005-04-15 2020-08-04 Epigenomics Ag Method for determining the presence or absence of methylation in a sample

Also Published As

Publication number Publication date
AU2003281281A1 (en) 2004-01-23
EP1527198A1 (fr) 2005-05-04
WO2004005543A1 (fr) 2004-01-15
US20060210976A1 (en) 2006-09-21

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