[go: up one dir, main page]

DE10224624A1 - Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol - Google Patents

Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol

Info

Publication number
DE10224624A1
DE10224624A1 DE10224624A DE10224624A DE10224624A1 DE 10224624 A1 DE10224624 A1 DE 10224624A1 DE 10224624 A DE10224624 A DE 10224624A DE 10224624 A DE10224624 A DE 10224624A DE 10224624 A1 DE10224624 A1 DE 10224624A1
Authority
DE
Germany
Prior art keywords
acid
stereoisomers
salts
dimethylamino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10224624A
Other languages
German (de)
English (en)
Inventor
Helmut Buschmann
Thomas Christoph
Joerg Holenz
Burkhard Kurth
Oswald Zimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE10224624A priority Critical patent/DE10224624A1/de
Priority to AU2003238398A priority patent/AU2003238398A1/en
Priority to EP03732465A priority patent/EP1507521A1/de
Priority to PCT/EP2003/005490 priority patent/WO2003101440A1/de
Priority to PE2003000510A priority patent/PE20040521A1/es
Priority to ARP030101885A priority patent/AR039901A1/es
Publication of DE10224624A1 publication Critical patent/DE10224624A1/de
Priority to US10/999,219 priority patent/US20050137145A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/72—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE10224624A 2002-05-30 2002-05-30 Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol Withdrawn DE10224624A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE10224624A DE10224624A1 (de) 2002-05-30 2002-05-30 Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol
AU2003238398A AU2003238398A1 (en) 2002-05-30 2003-05-26 Metabolite of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentane-3-ol and the use thereof in the treatment of urinary incontinence
EP03732465A EP1507521A1 (de) 2002-05-30 2003-05-26 Metabolite von 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol sowie deren verwendung zur behandlung von harninkontinenz
PCT/EP2003/005490 WO2003101440A1 (de) 2002-05-30 2003-05-26 Metabolite von 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol sowie deren verwendung zur behandlung von harninkontinenz
PE2003000510A PE20040521A1 (es) 2002-05-30 2003-05-27 Metabolito a partir de 1-dimetilamino-3-(3-metoxi-fenil)-2-metil-pentan-3-ol
ARP030101885A AR039901A1 (es) 2002-05-30 2003-05-29 Metabolito a partir de 1-dimetilamino-3-(3-metoxi-fenil)-2-metil-pentan-3-ol
US10/999,219 US20050137145A1 (en) 2002-05-30 2004-11-30 Metabolites of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol and their use in the treatment of urinary incontinence

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10224624A DE10224624A1 (de) 2002-05-30 2002-05-30 Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol

Publications (1)

Publication Number Publication Date
DE10224624A1 true DE10224624A1 (de) 2003-12-11

Family

ID=29432607

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10224624A Withdrawn DE10224624A1 (de) 2002-05-30 2002-05-30 Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol

Country Status (6)

Country Link
EP (1) EP1507521A1 (es)
AR (1) AR039901A1 (es)
AU (1) AU2003238398A1 (es)
DE (1) DE10224624A1 (es)
PE (1) PE20040521A1 (es)
WO (1) WO2003101440A1 (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
WO2002043715A2 (de) * 2000-11-30 2002-06-06 Grünenthal GmbH Verwendung von 1-phenyl-3-dimethylamino-propanverbindungen zur therapie der harninkontinenz

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2901180A1 (de) * 1979-01-13 1980-07-24 Basf Ag Hexahydro-1,4-oxazepine, verfahren zu deren herstellung und diese enthaltende arzneimittel
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
WO2002043715A2 (de) * 2000-11-30 2002-06-06 Grünenthal GmbH Verwendung von 1-phenyl-3-dimethylamino-propanverbindungen zur therapie der harninkontinenz

Also Published As

Publication number Publication date
PE20040521A1 (es) 2004-08-24
WO2003101440A1 (de) 2003-12-11
AU2003238398A1 (en) 2003-12-19
EP1507521A1 (de) 2005-02-23
AR039901A1 (es) 2005-03-09

Similar Documents

Publication Publication Date Title
EP1429754B1 (de) Kombination ausgewählter opioide mit muscarin-antagonisten zur therapie der harninkontinenz
EP2117525B1 (de) Verwendung von 1-phenyl-3-dimethylamino-propanverbindungen zur therapie des neuropathieschmerzes
EP3241550B1 (de) (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol zur behandlung von entzündungsschmerz
DE10224107A1 (de) Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz
EP1438034B1 (de) Verwendung von 1-phenyl-3-dimethylamino-propan-verbindungen zur therapie der harninkontinenz
EP1337246B1 (de) Verwendung von 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz
EP1353660B1 (de) Verwendung von substituierten 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz
EP1509216B1 (de) Wirkstoffsalze und ester von 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol und 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methyl-propyl)-phenol
WO2005011684A1 (de) Arzneimittel enthaltend derivate von aryl(oder heteroaryl)azolylcarbinolen
DE10224624A1 (de) Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol
US20050137194A1 (en) Combination of selected opioids with other active compounds for treatment of urinary incontinence
US20050137145A1 (en) Metabolites of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol and their use in the treatment of urinary incontinence
DE10254785A1 (de) Kombination ausgewählter Analgetika mit COX II-Inhibitoren
DE10326103A1 (de) Kombination ausgewählter Analgetika mit COX II-Inhibitoren

Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8139 Disposal/non-payment of the annual fee