DE102005026809A1 - Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen - Google Patents

Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen Download PDF

Info

Publication number: DE102005026809A1
Authority: DE; Germany
Prior art keywords: alkyl; formula; compounds; heteroaryl; hydrogen
Prior art date: 2005-06-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

DE102005026809A

Other languages

German (de)

English (en)

Inventor

Gerhard Dr. Zoller

Stefan Dr. Petry

Günter Dr. Müller

Hubert Dr. Heuer

Norbert Dr. Tennagels

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Aventis Deutschland GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2005-06-09

Publication date

2006-12-14

2005-06-09 Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH

2005-06-09 Priority to DE102005026809A priority Critical patent/DE102005026809A1/de

2006-05-27 Priority to DE502006008717T priority patent/DE502006008717D1/de

2006-05-27 Priority to AU2006257023A priority patent/AU2006257023A1/en

2006-05-27 Priority to CA002609560A priority patent/CA2609560A1/fr

2006-05-27 Priority to JP2008515096A priority patent/JP2008542411A/ja

2006-05-27 Priority to KR1020077028744A priority patent/KR20080014020A/ko

2006-05-27 Priority to RU2007145476/04A priority patent/RU2007145476A/ru

2006-05-27 Priority to EP06753938A priority patent/EP1896435B1/fr

2006-05-27 Priority to NZ564061A priority patent/NZ564061A/en

2006-05-27 Priority to BRPI0611918-2A priority patent/BRPI0611918A2/pt

2006-05-27 Priority to CNA2006800199269A priority patent/CN101189218A/zh

2006-05-27 Priority to PCT/EP2006/005096 priority patent/WO2006131232A1/fr

2006-05-27 Priority to AT06753938T priority patent/ATE495163T1/de

2006-05-27 Priority to MX2007015269A priority patent/MX2007015269A/es

2006-06-07 Priority to TW095120138A priority patent/TW200716581A/zh

2006-06-07 Priority to ARP060102371A priority patent/AR054198A1/es

2006-06-07 Priority to MYPI20062624A priority patent/MY146803A/en

2006-06-09 Priority to UY29594A priority patent/UY29594A1/es

2006-12-14 Publication of DE102005026809A1 publication Critical patent/DE102005026809A1/de

2007-11-22 Priority to MA30416A priority patent/MA29482B1/fr

2007-11-28 Priority to IL187729A priority patent/IL187729A0/en

2007-12-05 Priority to US11/950,948 priority patent/US8008331B2/en

2008-01-03 Priority to NO20080034A priority patent/NO20080034L/no

Status Withdrawn legal-status Critical Current

Links

YEDUAINPPJYDJZ-UHFFFAOYSA-N 2-hydroxybenzothiazole Chemical class C1=CC=C2SC(O)=NC2=C1 YEDUAINPPJYDJZ-UHFFFAOYSA-N 0.000 title claims abstract description 14
239000003112 inhibitor Substances 0.000 title description 14
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239000004367 Lipase Substances 0.000 title description 4
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108010064785 Phospholipases Proteins 0.000 title description 2
102000015439 Phospholipases Human genes 0.000 title description 2
239000003814 drug Substances 0.000 claims abstract description 14
150000003839 salts Chemical class 0.000 claims abstract description 14
150000001875 compounds Chemical class 0.000 claims description 105
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 43
239000001257 hydrogen Substances 0.000 claims description 28
229910052739 hydrogen Inorganic materials 0.000 claims description 28
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229910052736 halogen Inorganic materials 0.000 claims description 23
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 22
125000004122 cyclic group Chemical group 0.000 claims description 19
238000011282 treatment Methods 0.000 claims description 19
239000000203 mixture Substances 0.000 claims description 17
125000002619 bicyclic group Chemical group 0.000 claims description 16
125000001072 heteroaryl group Chemical group 0.000 claims description 16
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 15
239000004480 active ingredient Substances 0.000 claims description 15
238000002360 preparation method Methods 0.000 claims description 15
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125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
125000004429 atom Chemical group 0.000 claims description 9
125000003545 alkoxy group Chemical group 0.000 claims description 8
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Classifications

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DE102005026809A 2005-06-09 2005-06-09 Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen Withdrawn DE102005026809A1 (de)

Priority Applications (22)

Application Number	Priority Date	Filing Date	Title
DE102005026809A DE102005026809A1 (de)	2005-06-09	2005-06-09	Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
AT06753938T ATE495163T1 (de)	2005-06-09	2006-05-27	Benzothiazol-2-on-derivate als inhibitoren von lipasen und phospholipasen
PCT/EP2006/005096 WO2006131232A1 (fr)	2005-06-09	2006-05-27	Derives de benzothiazol-2-one servant d'inhibiteurs de lipases et de phospholipases
CA002609560A CA2609560A1 (fr)	2005-06-09	2006-05-27	Derives de benzothiazol-2-one servant d'inhibiteurs de lipases et de phospholipases
JP2008515096A JP2008542411A (ja)	2005-06-09	2006-05-27	リパーゼ及びホスホリパーゼ阻害剤としてのベンゾチアゾール−２−オン誘導体
KR1020077028744A KR20080014020A (ko)	2005-06-09	2006-05-27	리파제 및 포스포리파제 억제제로서의 벤조티아졸-2-온유도체
RU2007145476/04A RU2007145476A (ru)	2005-06-09	2006-05-27	Производные бензотиазол-2-она как ингибиторы липаз и фосфолипаз
EP06753938A EP1896435B1 (fr)	2005-06-09	2006-05-27	Derives de benzothiazol-2-one servant d'inhibiteurs de lipases et de phospholipases
MX2007015269A MX2007015269A (es)	2005-06-09	2006-05-27	Derivados de benzotiazol-2-ona como inhibidores de lipasas y fosfolipasas.
AU2006257023A AU2006257023A1 (en)	2005-06-09	2006-05-27	Benzothiazol-2-on derivatives as lipase and phospholipase inhibitors
CNA2006800199269A CN101189218A (zh)	2005-06-09	2006-05-27	作为脂酶和磷脂酶抑制剂的苯并噻唑-2-酮衍生物
DE502006008717T DE502006008717D1 (de)	2005-06-09	2006-05-27	Benzothiazol-2-on-derivate als inhibitoren von lipasen und phospholipasen
BRPI0611918-2A BRPI0611918A2 (pt)	2005-06-09	2006-05-27	derivados de benzotiazol-2-ona como inibidores da lipase e fosfolipase
NZ564061A NZ564061A (en)	2005-06-09	2006-05-27	Benzothiazol-2-one derivatives as lipase and phospholipase inhibitors
TW095120138A TW200716581A (en)	2005-06-09	2006-06-07	Benzothiazol-2-one derivatives as inhibitors of lipases and phospholipases
ARP060102371A AR054198A1 (es)	2005-06-09	2006-06-07	Derivados de benzotiazol-2-ona como inhibidores de lipasas y fosflipasas
MYPI20062624A MY146803A (en)	2005-06-09	2006-06-07	Benzothiazol-2-on derivatives as lipase and phospholipase inhibitors
UY29594A UY29594A1 (es)	2005-06-09	2006-06-09	Derivados de benzotiazol-2-ona como inhibidores de lipasas y fosfolipasas
MA30416A MA29482B1 (fr)	2005-06-09	2007-11-22	Derives de benzothiazol-2-one derivatives en tant qu'inhibiteurs de lipase et de phospholipase
IL187729A IL187729A0 (en)	2005-06-09	2007-11-28	Benzothiazol-2-on derivatives as lipase and phospholipase inhibitors
US11/950,948 US8008331B2 (en)	2005-06-09	2007-12-05	Benzothiazol-2-one derivatives as lipase and phospholipase inhibitors
NO20080034A NO20080034L (no)	2005-06-09	2008-01-03	Benzotiazol-2-on derivater som lipase og fosfolipaseinhibitorer

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102005026809A DE102005026809A1 (de)	2005-06-09	2005-06-09	Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

Publication Number	Publication Date
DE102005026809A1 true DE102005026809A1 (de)	2006-12-14

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ID=36699315

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE102005026809A Withdrawn DE102005026809A1 (de)	2005-06-09	2005-06-09	Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE502006008717T Active DE502006008717D1 (de)	2005-06-09	2006-05-27	Benzothiazol-2-on-derivate als inhibitoren von lipasen und phospholipasen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE502006008717T Active DE502006008717D1 (de)	2005-06-09	2006-05-27	Benzothiazol-2-on-derivate als inhibitoren von lipasen und phospholipasen

Country Status (21)

Country	Link
US (1)	US8008331B2 (fr)
EP (1)	EP1896435B1 (fr)
JP (1)	JP2008542411A (fr)
KR (1)	KR20080014020A (fr)
CN (1)	CN101189218A (fr)
AR (1)	AR054198A1 (fr)
AT (1)	ATE495163T1 (fr)
AU (1)	AU2006257023A1 (fr)
BR (1)	BRPI0611918A2 (fr)
CA (1)	CA2609560A1 (fr)
DE (2)	DE102005026809A1 (fr)
IL (1)	IL187729A0 (fr)
MA (1)	MA29482B1 (fr)
MX (1)	MX2007015269A (fr)
MY (1)	MY146803A (fr)
NO (1)	NO20080034L (fr)
NZ (1)	NZ564061A (fr)
RU (1)	RU2007145476A (fr)
TW (1)	TW200716581A (fr)
UY (1)	UY29594A1 (fr)
WO (1)	WO2006131232A1 (fr)

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DE102005026808A1 (de) *	2005-06-09	2006-12-14	Sanofi-Aventis Deutschland Gmbh	Benzooxazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
EP2025674A1 (fr)	2007-08-15	2009-02-18	sanofi-aventis	Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
WO2010003624A2 (fr)	2008-07-09	2010-01-14	Sanofi-Aventis	Composés hétérocycliques, leurs procédés de préparation, médicaments comprenant lesdits composés et leur utilisation
JP5605844B2 (ja)	2008-10-17	2014-10-15	塩野義製薬株式会社	血管内皮リパーゼ阻害活性を有する酢酸アミド誘導体
KR20120123325A (ko)	2009-12-15	2012-11-08	시오노기세야쿠 가부시키가이샤	혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체
CN101845027B (zh) *	2010-05-28	2012-11-21	浙江工业大学	一种n-取代苯基-苯并噻唑酮-3-甲酰胺衍生物
WO2011157827A1 (fr)	2010-06-18	2011-12-22	Sanofi	Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases

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EP0334134A1 (fr) *	1988-03-25	1989-09-27	Bayer Ag	Benzothiazolones 3,7-disubstituées
WO2003051841A2 (fr) *	2001-12-14	2003-06-26	Novo Nordisk A/S	Composes ralentissant l'activite de la lipase hormono-sensible

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JPS61155376A (ja) *	1984-12-28	1986-07-15	Idemitsu Kosan Co Ltd	ベンゾチアゾロン誘導体，その製造方法およびそれを有効成分とする農園芸用殺菌剤
DE10247680B4 (de) *	2002-10-12	2005-09-01	Aventis Pharma Deutschland Gmbh	Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase

2005
- 2005-06-09 DE DE102005026809A patent/DE102005026809A1/de not_active Withdrawn
2006
- 2006-05-27 CA CA002609560A patent/CA2609560A1/fr not_active Abandoned
- 2006-05-27 BR BRPI0611918-2A patent/BRPI0611918A2/pt not_active IP Right Cessation
- 2006-05-27 RU RU2007145476/04A patent/RU2007145476A/ru not_active Application Discontinuation
- 2006-05-27 DE DE502006008717T patent/DE502006008717D1/de active Active
- 2006-05-27 EP EP06753938A patent/EP1896435B1/fr active Active
- 2006-05-27 NZ NZ564061A patent/NZ564061A/en not_active IP Right Cessation
- 2006-05-27 KR KR1020077028744A patent/KR20080014020A/ko not_active Withdrawn
- 2006-05-27 CN CNA2006800199269A patent/CN101189218A/zh active Pending
- 2006-05-27 MX MX2007015269A patent/MX2007015269A/es active IP Right Grant
- 2006-05-27 JP JP2008515096A patent/JP2008542411A/ja not_active Abandoned
- 2006-05-27 WO PCT/EP2006/005096 patent/WO2006131232A1/fr not_active Ceased
- 2006-05-27 AT AT06753938T patent/ATE495163T1/de active
- 2006-05-27 AU AU2006257023A patent/AU2006257023A1/en not_active Abandoned
- 2006-06-07 MY MYPI20062624A patent/MY146803A/en unknown
- 2006-06-07 AR ARP060102371A patent/AR054198A1/es not_active Application Discontinuation
- 2006-06-07 TW TW095120138A patent/TW200716581A/zh unknown
- 2006-06-09 UY UY29594A patent/UY29594A1/es not_active Application Discontinuation
2007
- 2007-11-22 MA MA30416A patent/MA29482B1/fr unknown
- 2007-11-28 IL IL187729A patent/IL187729A0/en unknown
- 2007-12-05 US US11/950,948 patent/US8008331B2/en not_active Expired - Fee Related
2008
- 2008-01-03 NO NO20080034A patent/NO20080034L/no not_active Application Discontinuation

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EP0334134A1 (fr) *	1988-03-25	1989-09-27	Bayer Ag	Benzothiazolones 3,7-disubstituées
WO2003051841A2 (fr) *	2001-12-14	2003-06-26	Novo Nordisk A/S	Composes ralentissant l'activite de la lipase hormono-sensible

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Also Published As

Publication number	Publication date
NO20080034L (no)	2008-03-10
RU2007145476A (ru)	2009-06-20
IL187729A0 (en)	2008-08-07
AU2006257023A1 (en)	2006-12-14
JP2008542411A (ja)	2008-11-27
BRPI0611918A2 (pt)	2010-10-05
ATE495163T1 (de)	2011-01-15
KR20080014020A (ko)	2008-02-13
CN101189218A (zh)	2008-05-28
NZ564061A (en)	2010-07-30
EP1896435A1 (fr)	2008-03-12
WO2006131232A1 (fr)	2006-12-14
MA29482B1 (fr)	2008-05-02
MX2007015269A (es)	2008-02-21
CA2609560A1 (fr)	2006-12-14
MY146803A (en)	2012-09-28
US8008331B2 (en)	2011-08-30
EP1896435B1 (fr)	2011-01-12
UY29594A1 (es)	2007-01-31
TW200716581A (en)	2007-05-01
AR054198A1 (es)	2007-06-06
US20080161370A1 (en)	2008-07-03
DE502006008717D1 (de)	2011-02-24

Publication	Publication Date	Title
EP1713779B1 (fr)	2011-04-13	Derives d'indazole utilises comme inhibiteurs de la lipase hormono-sensible
DE102005018389A1 (de)	2006-10-26	Azolderivate als Inhibitoren von Lipasen und Phospholipasen
DE102005048897A1 (de)	2007-04-19	Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049954A1 (de)	2007-05-31	Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102006014688A1 (de)	2007-10-04	Azolopyridin-3-on-derivate als Inhibitoren von Lipasen und Phospholipasen
EP1554259B1 (fr)	2006-12-27	Inhibiteurs bicycliques de la lipase hormono-sensible
DE102006014685A1 (de)	2007-10-04	Imidazo-pyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholiphasen
DE102005049953A1 (de)	2007-04-26	Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen
US7846943B2 (en)	2010-12-07	Azolopyridin-2-one derivatives as lipase and phospholipase inhibitors
US7709513B2 (en)	2010-05-04	Benzooxazol-2-one derivatives as lipase and phospholipase inhibitors
US8008331B2 (en)	2011-08-30	Benzothiazol-2-one derivatives as lipase and phospholipase inhibitors

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2006-12-14	OP8	Request for examination as to paragraph 44 patent law
2007-09-06	8127	New person/name/address of the applicant	Owner name: SANOFI-AVENTIS, PARIS, FR
2011-01-13	8130	Withdrawal