DE10144765A1 - Extract available from Artemisia abrotanum L. (Eberraute) - Google Patents
Extract available from Artemisia abrotanum L. (Eberraute)Info
- Publication number
- DE10144765A1 DE10144765A1 DE10144765A DE10144765A DE10144765A1 DE 10144765 A1 DE10144765 A1 DE 10144765A1 DE 10144765 A DE10144765 A DE 10144765A DE 10144765 A DE10144765 A DE 10144765A DE 10144765 A1 DE10144765 A1 DE 10144765A1
- Authority
- DE
- Germany
- Prior art keywords
- aqueous
- extract
- percolation
- liquids
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000284 extract Substances 0.000 title claims abstract description 23
- 244000249062 Artemisia abrotanum Species 0.000 title claims abstract description 20
- 235000015700 Artemisia abrotanum Nutrition 0.000 title claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 238000005325 percolation Methods 0.000 claims abstract description 11
- 241000196324 Embryophyta Species 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims abstract description 6
- 239000010432 diamond Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 229910003460 diamond Inorganic materials 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 241000700605 Viruses Species 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000003612 virological effect Effects 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 241000606161 Chlamydia Species 0.000 claims description 2
- 208000035473 Communicable disease Diseases 0.000 claims description 2
- 241000701022 Cytomegalovirus Species 0.000 claims description 2
- 241000709661 Enterovirus Species 0.000 claims description 2
- 208000005176 Hepatitis C Diseases 0.000 claims description 2
- 208000009889 Herpes Simplex Diseases 0.000 claims description 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims description 2
- 241000589248 Legionella Species 0.000 claims description 2
- 208000007764 Legionnaires' Disease Diseases 0.000 claims description 2
- 241000204031 Mycoplasma Species 0.000 claims description 2
- 241000702670 Rotavirus Species 0.000 claims description 2
- 241000202898 Ureaplasma Species 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 208000002672 hepatitis B Diseases 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 241000025483 Symphonia globulifera Species 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000012239 Developmental disease Diseases 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 244000019194 Sorbus aucuparia Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Extrakt erhältlich durch Perkolation oberirdischer Pflanzenteile von Artemisia abrotanum L. (Eberraute) mit wässrigen oder wässrig-alkoholischen Flüssigkeiten ggf. gefolgt von Trocknung des mit wässrigen oder wässrig-alkoholischen Flüssigkeiten gewonnenen Extraktes.Extract obtainable by percolation of above-ground parts of plants from Artemisia abrotanum L. (Eberraute) with aqueous or aqueous-alcoholic liquids, possibly followed by drying of the extract obtained with aqueous or aqueous-alcoholic liquids.
Description
Die vorliegende Erfindung betrifft einen Extrakt erhältlich durch Perkolation oberirdischer Pflanzenteile von Artemisia abrotanum L. (Eberraute) mit wässrigen oder wässrig-alkoholischen Flüssigkeiten, ein Verfahren zu seiner Herstellung, ein Arzneimittel enthaltend den erfindungsgemäßen Extrakt sowie bestimmte Indikationen des erfindungsgemäßen Arzneimittels. The present invention relates to an extract obtainable by percolation above-ground parts of plants from Artemisia abrotanum L. (Eberraute) with aqueous or aqueous-alcoholic liquids, a process for its Production, a medicament containing the extract according to the invention and certain indications of the medicament according to the invention.
Die Eberraute, Artemisia abrotanum, ist eine auch in Deutschland heimische Pflanze, die in der Volksmedizin als Heilpflanze traditionell benutzt wird. Üblicherweise werden Tees oder Tinkturen dieser Pflanze verwendet. Anwendungsgebiete sind Behandlung von Abmagerung und Entwicklungsstörungen bei Kindern, unspezifische chronische Entzündungen, Hauterkrankungen, Rheumatismus und Gicht. The boar diamond, Artemisia abrotanum, is also native to Germany Plant that is traditionally used as a medicinal plant in folk medicine. Teas or tinctures of this plant are usually used. Areas of application are treatment of weight loss and Developmental disorders in children, non-specific chronic inflammation, Skin diseases, rheumatism and gout.
Überraschenderweise wurde gefunden, dass ein Extrakt der Eberraute als Arzneimittel gegen virale und bakterielle Infektionen wirksam ist. Surprisingly, it was found that an extract of the boar diamond as Medicinal product against viral and bacterial infections is effective.
Gegenstand der vorliegenden Erfindung ist daher ein Extrakt, der durch Perkolation oberirdischer Pflanzenteile von Artemisia abrotanum L. (Eberraute) mit wässrigen oder wässrig-alkoholischen Flüssigkeiten erhältlich ist, ggf. gefolgt von Trocknung des mit wässrigen oder wässrig-alkoholischen Flüssigkeiten gewonnenen Extraktes. Durch die Trocknung des durch Perkolation erhaltenen flüssigen Extraktes sind feste, insbesondere pulverförmige erhältlich. Letztere können mit Trägerstoffen vermischt und in üblichen galenischen Zubereitungen formuliert werden. Dazu gehören z. B. Tabletten, Dragees, Kapseln. The subject of the present invention is therefore an extract which Percolation of aerial parts of plants from Artemisia abrotanum L. (Eberraute) is available with aqueous or aqueous-alcoholic liquids, if necessary followed by drying the with aqueous or aqueous-alcoholic Extract obtained from liquids. By drying the through Percolation liquid extract obtained are solid, in particular powdery available. The latter can be mixed with carriers and in usual galenical preparations can be formulated. These include e.g. B. Tablets, dragees, capsules.
Auch die flüssigen Extrakte sind zur Verwendung geeignet, können jedoch ebenfalls mit in der pharmazeutischen Technologie üblichen Flüssigkeiten vermischt werden zwecks Verdünnung oder Erleichterung der Administration. The liquid extracts are also suitable for use, but can also with liquids common in pharmaceutical technology are mixed to dilute or facilitate administration.
Vorzugsweise ist der erfindungsgemäße Extrakt durch Perkolation getrockneter oberirdischer Teile der Eberrautenpflanzen erhältlich. Der erfindungsgemäße Extrakt wird bevorzugterweise so gewonnen, dass das Mengenverhältnis der oberirdisch getrockneten Teile der Eberraute : Extraktionsmittel = 2,5-5,5 : 1 (w/w) beträgt. The extract according to the invention is preferably dried by percolation Above ground parts of the rowan plants available. The invention Extract is preferably obtained so that the quantitative ratio of Parts of the boar diamond dried above ground: extractant = 2.5-5.5: 1 (w / w) is.
Das erfindungsgemäße Verfahren zur Herstellung des erfindungsgemäßen
Extrakts von Artemisia abrotanum L. (Eberraute) umfasst die folgenden
Schritte:
- - eine Perkolation von oberirdischen Pflanzenteilen von Artemisia abrotanum L. (Eberraute) mit wässrigen oder wässrig-alkoholischen Flüssigkeiten,
- - ggf. gefolgt von einer Trocknung des mit wässrigen oder wässrig- alkoholischen Flüssigkeiten gewonnenen Extraktes. Vorzugsweise erfolgt die Extraktion mit heißen Flüssigkeiten. Als Flüssigkeiten werden im erfindungsgemäßen Verfahren insbesondere Wasser oder Gemische aus Et-OH/Wasser verwendet.
- a percolation of above-ground parts of plants from Artemisia abrotanum L. (Eberraute) with aqueous or aqueous-alcoholic liquids,
- - optionally followed by drying of the extract obtained with aqueous or aqueous-alcoholic liquids. The extraction is preferably carried out with hot liquids. In particular, water or mixtures of Et-OH / water are used as liquids in the process according to the invention.
Die Perkolation erfolgt vorzugsweise mit getrockneten Eberrautenpflanzenteilen. Das Mengenverhältnis der oberirdisch getrockneten Teile der Eberraute : Extraktionsmittel beträgt 2,5-5, 5 : 1 (w/w). Percolation is preferably carried out with dried Eberrautenpflanzenteilen. The quantitative ratio of the dried above ground Parts of the boar diamond: extracting agent is 2.5-5.5: 1 (w / w).
Gegenstand der Erfindung ist auch ein Arzneimittel enthaltend den erfindungsgemäßen Extrakt. Das erfindungsgemäße Arzneimittel ist insbesondere zur Behandlung von viralen und/oder bakteriellen Infektionserkrankungen geeignet. The invention also relates to a medicament containing the extract according to the invention. The medicament according to the invention is especially for the treatment of viral and / or bacterial Infectious diseases suitable.
Gegenstand der Erfindung ist des Weiteren eine Verwendung des erfindungsgemäßen Extraktes zur Herstellung eines Arzneimittels zur Behandlung von viralen und/oder bakteriellen Infektionserkrankungen. Die Infektionserkrankungen beruhen insbesondere auf Infektionen mit Herpes simplex I- und II-Viren, Hepatitis B- und C-Viren, Rota-/Entero-Viren, dem Cytomegalie-Virus, dem Epstein-Barr-Virus, RS-Viren, Chlamydien, Ureaplasmen, Legionellen, Mykoplasmen oder Kombinationen davon. The invention further relates to a use of the extract according to the invention for the manufacture of a medicament for Treatment of viral and / or bacterial infectious diseases. The infectious diseases are based in particular on infections with herpes simplex I and II viruses, hepatitis B and C viruses, Rota / Entero viruses, the Cytomegalovirus, the Epstein-Barr virus, RS viruses, chlamydia, Ureaplasmas, legionella, mycoplasma or combinations thereof.
Claims (11)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10144765A DE10144765A1 (en) | 2001-09-11 | 2001-09-11 | Extract available from Artemisia abrotanum L. (Eberraute) |
| PCT/EP2002/010203 WO2003022294A2 (en) | 2001-09-11 | 2002-09-11 | Extract obtainable from artemisia abrotanum l. (southernwood) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10144765A DE10144765A1 (en) | 2001-09-11 | 2001-09-11 | Extract available from Artemisia abrotanum L. (Eberraute) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10144765A1 true DE10144765A1 (en) | 2003-04-30 |
Family
ID=7698661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10144765A Withdrawn DE10144765A1 (en) | 2001-09-11 | 2001-09-11 | Extract available from Artemisia abrotanum L. (Eberraute) |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE10144765A1 (en) |
| WO (1) | WO2003022294A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2890312B1 (en) * | 2005-09-02 | 2007-10-19 | Limousine D Applic Biolog Dite | PROCESS FOR OBTAINING AN ACTIVE REPULPENT PRINCIPLE, ACTIVE INGREDIENT OBTAINED AND COSMETIC COMPOSITIONS INCLUDING THE SAME |
| US20110274776A1 (en) * | 2010-05-07 | 2011-11-10 | Michael Anthonavage | Compositions comprising extracts of southernwood and an amine compound |
| US20110274775A1 (en) * | 2010-05-07 | 2011-11-10 | Michael Anthonavage | Extracts of southernwood and topical uses thereof |
| WO2015030567A1 (en) * | 2013-08-30 | 2015-03-05 | Zamarripa Blas Juan Alberto | Improvements to a complementary formulation for counteracting adverse effects of cancer treatments and of treatments for some viral diseases |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4131313A1 (en) * | 1991-09-20 | 1993-03-25 | Karl Konrad | Medicament from camomile flowers - contains non-polar active agent obtd. by aq. extn. in presence of ascorbic acid |
| DE69218764T2 (en) * | 1991-02-28 | 1997-08-14 | Phytotech Ltd | PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT OF SKIN DAMAGE |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3000521A1 (en) * | 1979-01-10 | 1980-07-24 | Kitasato Inst | SUBSTANCE WITH INTERFERON INDUCING ACTIVITY AND METHOD FOR THEIR PRODUCTION |
-
2001
- 2001-09-11 DE DE10144765A patent/DE10144765A1/en not_active Withdrawn
-
2002
- 2002-09-11 WO PCT/EP2002/010203 patent/WO2003022294A2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69218764T2 (en) * | 1991-02-28 | 1997-08-14 | Phytotech Ltd | PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT OF SKIN DAMAGE |
| DE4131313A1 (en) * | 1991-09-20 | 1993-03-25 | Karl Konrad | Medicament from camomile flowers - contains non-polar active agent obtd. by aq. extn. in presence of ascorbic acid |
Non-Patent Citations (1)
| Title |
|---|
| Hagers Handbuch der pharmazeutischen Praxis, Springer verlag, 5. Aufl., 1992, 4. Bd., S. 358-359 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003022294A2 (en) | 2003-03-20 |
| WO2003022294A3 (en) | 2003-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8139 | Disposal/non-payment of the annual fee |