DE1081607B - Procedure for packaging medicinal products - Google Patents
Procedure for packaging medicinal productsInfo
- Publication number
- DE1081607B DE1081607B DEF28063A DEF0028063A DE1081607B DE 1081607 B DE1081607 B DE 1081607B DE F28063 A DEF28063 A DE F28063A DE F0028063 A DEF0028063 A DE F0028063A DE 1081607 B DE1081607 B DE 1081607B
- Authority
- DE
- Germany
- Prior art keywords
- parts
- weight
- esters
- procedure
- medicinal products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 5
- 229940126601 medicinal product Drugs 0.000 title description 2
- 238000004806 packaging method and process Methods 0.000 title 1
- 238000000576 coating method Methods 0.000 claims description 8
- 150000002148 esters Chemical class 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- 150000001991 dicarboxylic acids Chemical class 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000008393 encapsulating agent Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 229920006027 ternary co-polymer Polymers 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- QIZPVNNYFKFJAD-UHFFFAOYSA-N 1-chloro-2-prop-1-ynylbenzene Chemical compound CC#CC1=CC=CC=C1Cl QIZPVNNYFKFJAD-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229920002494 Zein Polymers 0.000 description 2
- 238000007605 air drying Methods 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000008236 heating water Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000151 polyglycol Polymers 0.000 description 2
- 239000010695 polyglycol Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- -1 sorbitan fatty acid esters Chemical class 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229940035023 sucrose monostearate Drugs 0.000 description 2
- 239000005019 zein Substances 0.000 description 2
- 229940093612 zein Drugs 0.000 description 2
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical group O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940116224 behenate Drugs 0.000 description 1
- UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-N sodium;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O QGMRQYFBGABWDR-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Description
Verfahren zur Umhüllung von Arzneimitteln Für die Umhüllung von Arzneizubereitungen, wie Tabletten, Pillen, Granulaten u. a., werden zahlreiche Stoffe verwendet, die an Stellelder konventionellen Zuckerdragierung Verwendung finden können. Es handelt sich dabei vornehmlich um natürlich vorkommende oder um synthetische, plastische Stoffe, die für sich oder in Kombination mit anderen Stoffen verwendet werden, wie Polyäthylenglykol, Hy!droxyäthylcellulose, Natriumcarboxymethylcellulose, Zein, Silivone, Polyvinylpyrollidon, Celluloseacetatphtalat usw. Process for the coating of medicinal products For the coating of medicinal preparations, such as tablets, pills, granules and others, numerous substances are used that can be used instead of conventional sugar coating. It deals mainly naturally occurring or synthetic, plastic Substances that are used on their own or in combination with other substances, such as Polyethylene glycol, hydroxyethyl cellulose, sodium carboxymethyl cellulose, zein, Silivone, polyvinylpyrollidone, cellulose acetate phthalate, etc.
Allen diesen Stoffen haften aber gewisse Mängel an, sei es, !daß, wie z. B. bei Zein, eine gewisse Porosität bei den gebiideten Filmen nicht ausgeschaltet werden kann oder daß diese beim Lagern einem Alterungsprozeß unterliegen, sei es, daß, wie bei den Polyäthylenglykolen, diese infolge ihres verhältnismäßig niedrigen Schmelzpunktes anfällig gegenüber Wärme sind oder daß, wie z. B. Polyvinylpyrollidon, der Stoff infolge seiner großen Klebrigkeit Schwierigkeiten bereitet oder aber daß die Stoffe, wie bei den Cellulosederivaten, nur in Wasser zbzw. Wasser - Alkohol löslich sind und daher nur begrenzte Anwendungsmöglichkeiten besitzen. All of these substances, however, have certain defects, be it! That, such as B. in the case of zein, a certain porosity in the films formed is not eliminated or that they are subject to an aging process during storage, be it that, as with the polyethylene glycols, these due to their relatively low Melting point are sensitive to heat or that, such as. B. polyvinylpyrollidone, the substance causes difficulties due to its great stickiness or else that the substances, as with the cellulose derivatives, only zbzw in water. Water - alcohol are soluble and therefore have only limited application possibilities.
Es wurde nun überraschenderweise gefunden, daß die in der Patentanmeldung tF 26778 IVa/30h zur Herstellung von magensaftresistenten darmlöslichen Überzügen vorgeschlagenen ternären Mischpolymerisate, die unter Verwendung von Halbestern a,ß-ungesättigten Dicarbonsäuren, wasserunlöslichen Vinylverbindungen und Acrylsäure oder Methacrylsäure hergestellt werden, sich in Kombination mit festen Zuckerestern ausgezeichnet zur Umhüllung von Arzneizubereitungen, wie Tabletten usw., eignen, wobei die genannten Nachteile vermieden und leichtlösliche Umhüllungen erhalten werden. It has now surprisingly been found that in the patent application tF 26778 IVa / 30h for the production of enteric coatings that are resistant to gastric juice proposed ternary copolymers using half-esters α, β-unsaturated dicarboxylic acids, water-insoluble vinyl compounds and acrylic acid or methacrylic acid can be produced in combination with solid sugar esters excellent for wrapping medicinal preparations such as tablets, etc., the disadvantages mentioned being avoided and easily soluble coatings obtained will.
Es handelt sich bei den genannten Zuckerestern um Ester der Saccharose mit höheren Fettsäuren, wie sie schon als Emulgatoren in ,der Kosmetik verwendet werden. Insbesondere eignen sich als Umhüllungsmaterialien Ester der Saccharose mit Stearinsäure, Palmitinsäure, Behensäure u. a., zum Beispiel Saccharosemonostearat, Saccharosetripalmitat, Saccharosepentabehenat. Diese Ester werden zusammen mit den ternären Mischpolymerisaten in organischen Lösungsmitteln, wie Alkoholen, Ketonen oder Kohlenwasserstoffen, zumeist warm gelöst und als warme Lösungen auf die Arzneimittel aufgetragen. The sugar esters mentioned are esters of sucrose with higher fatty acids, as they are already used as emulsifiers in cosmetics will. In particular, sucrose esters are suitable as coating materials with stearic acid, palmitic acid, behenic acid and others, for example sucrose monostearate, Sucrose tripalmitate, sucrose pentabehenate. These esters are used together with the ternary copolymers in organic solvents such as alcohols, ketones or hydrocarbons, mostly dissolved warm and as warm solutions on the drugs applied.
Zur Verbesserung der Plastizität ,der Überzüge können noch andere niedrige, nichtionogene Emulgatoren oder Netzmittel, wie Sorbitanfettsäureester, Polyoxyäthylensorbitanfettsäureester oder Oleylpolyglykol äther, in Mengen von 2 bis 5 0/o zugesetzt werden. Nach Entfernen der Lösungsmittel verbleiben auf den Arzneikörpern festhaftende, ausgezeichnet abdeckende glatte Überzüge, die keine nennenswerte Verzögerung der Auflösungsgeschwindigkeit oder gar Resorptionsverzögerungen bewirken. Infolge der relativ hohen Schmelzpunkte der Zuckerester sind die gebildeten Filme verhältnismäßig unempfindlich gegenüber Wärme. Weiterhin besitzen die gebildeten Filme neben ihrer physiologischen Unbedenklichkeit eine sehr gute Haltbarkeit auch nach längerer Lagerung. To improve the plasticity, other coatings can also be used low, non-ionic emulsifiers or wetting agents, such as sorbitan fatty acid esters, Polyoxyethylene sorbitan fatty acid ester or oleyl polyglycol ether, in amounts of 2 to 50 / o are added. After removing the solvents, they remain on the Firmly adhering, excellent covering, smooth coatings that do not have any significant delay in the rate of dissolution or even resorption delays cause. As a result of the relatively high melting points of the sugar esters they are formed Films relatively insensitive to heat. Furthermore, the educated have Films in addition to their physiological harmlessness also have a very good durability after prolonged storage.
Beispiel 1 10 Gewichtsteile ternäres Mischpolymerisat, 35 Teile Saccharosemonostearat und 5 Gewichtsteile Oleylpolyglykoläther werden mit 120 Gewichtsteilen Aceton und 50 Gewichtsteilen Äthanol denaturiert auf dem Wasserbadbei 600 C Heizwassertemperatur bis zur Lösung erwärmt. Example 1 10 parts by weight of ternary copolymer, 35 parts of sucrose monostearate and 5 parts by weight of oleyl polyglycol ether with 120 parts by weight of acetone and 50 parts by weight of ethanol denatured on the water bath at 600 C heating water temperature warmed to solution.
Auf 20 000 Gewichtsteile N- Dimethylaminopropyl) -3-chlorphenothfazin-Tbietten mit einem Gewicht von 0,1 g werden in einem rotierenden Dragierkessel etwa 2500 Gewichtsteile obiger Lösung langsam auf gegossen, wobei zwischendurch schwach mit Warmluft von 300 C geblasen wird. On 20,000 parts by weight of N-dimethylaminopropyl) -3-chlorophenothfazine tablets with a weight of 0.1 g, about 2500 Parts by weight of the above solution slowly poured on, with weak in between Warm air of 300 C is blown.
Die so überzogenen Tabletten werden etwa 12 Stunden lin einem Umlufttrockenschrank ohne Beheizung getrocknet. The tablets coated in this way are left in a circulating air drying cabinet for about 12 hours dried without heating.
Beispiel 2 10 Gewichtsteile ternäres Mischpolymerisat, 30 Teile Saccharosepentalbehenat und 3 Gewichtsteile Sorbitantrioleat werden mit 120 Gewichtsteilen Aceton und 50 Gewichtsteilen Isopropanol auf dem Wasserbad bei 60 bis 800 C Heizwassertemperatur bis zur Lösung erwärmt. Example 2 10 parts by weight of ternary copolymer, 30 parts of sucrose pental behenate and 3 parts by weight of sorbitan trioleate are mixed with 120 parts by weight of acetone and 50 parts by weight of isopropanol on a water bath at 60 to 800 C heating water temperature warmed to solution.
Auf 17 500 Gewichtsteile Chloramphenicol-Tabletten mit einem Gewicht von 0,35 g werden in einem rotierenden Dragierkessel etwa 2000 Gewichtsteile obiger Lösung langsam aufgegossen, wobei zwischendurch schwach mit Warmluft von 300 C getrocknet wird. On 17,500 parts by weight of chloramphenicol tablets weighing of 0.35 g are about 2000 parts by weight of the above in a rotating coating pan Solution slowly poured on, with occasional drying with warm air of 300 ° C will.
Die so überzogenen Tabletten werden etwa 12 Stunden in einem Umlufttrockenschrank ohne Beheizung getrocknet. Dje überzogenen Tabletten unterscheiden sich in ihrem Zerfall in Wasser sowie im künstlichen Magen- und Darmsaft von 370 C nur unwesentlich von den nicht überzogenen Tabletten. The tablets coated in this way are placed in a circulating air drying cabinet for about 12 hours dried without heating. The coated tablets differ in theirs Disintegration in water and in artificial gastric and intestinal juice at 370 C is only insignificant of the uncoated tablets.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF28063A DE1081607B (en) | 1959-03-28 | 1959-03-28 | Procedure for packaging medicinal products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF28063A DE1081607B (en) | 1959-03-28 | 1959-03-28 | Procedure for packaging medicinal products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1081607B true DE1081607B (en) | 1960-05-12 |
Family
ID=7092728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEF28063A Pending DE1081607B (en) | 1959-03-28 | 1959-03-28 | Procedure for packaging medicinal products |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE1081607B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1228757B (en) * | 1962-06-28 | 1966-11-17 | Haessle Ab | Process for the production of a coating on solid dosage forms which disintegrates rapidly in water and gastric juice |
-
1959
- 1959-03-28 DE DEF28063A patent/DE1081607B/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1228757B (en) * | 1962-06-28 | 1966-11-17 | Haessle Ab | Process for the production of a coating on solid dosage forms which disintegrates rapidly in water and gastric juice |
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