DE1065571B - Protective agent with a content of! Hydrazine against the occurrence and multiplication of microorganisms - Google Patents

Description

It has been found that mixtures of hydrazine, which are preferably in the form of, for example 20- to 25% strength aqueous solutions is used, with surface-active compounds, which per se have little or no preservative and protective effect against microorganisms, Combinations with bactericidal and bacteriostatic properties greater than expected result. she therefore represent valuable means of protection against the occurrence and formation of microorganisms.

The toxicity of the hydrazine free base is in such Mixtures reduced so far that they can be used in veterinary and human disinfection without further ado are applicable. This is also explained by the fact that as a result of the synergistic effects Amounts of free hydrazine base can be kept very small.

Apart from in the form of the aqueous solutions, the hydrazine base can also be used in the form of its solutions in lower or middle alcohols, glycols, glycerin or polyglycerols, ketones or other organic ones Solvents are used which are able to absorb sufficient amounts of hydrazine.

Soaps, high molecular weight amino acids (protein degradation products), fatty acid condensation products, Alkyl sulfates, alkyl sulfonates, alkylbenzenesulfonates, sulfosuccinic acid esters, nonionic alkylene oxide adducts etc. applicable. These compounds are well known often used for purposes in which fungicidal and bactericidal effects are also desired at the same time are.

The above-described combinations of the hydrazine with surfactants can be used alone or in the Mixture with other preservatives can be used. Such substances are formaldehyde, paraldehyde, Phenols and cresols, o-phenylphenol, chlorophenols and chlorocresols, chlorinated oxydiphenylmethane derivatives, Salicylic acid derivatives, such as phenyl salicylate, salicylic acid anilide, phenyl mercury compounds, Propylene glycol and finally also inorganic products such as fluorides or silicofluorides. The main areas of application for hydrazine mixed with surface-active compounds and possibly other preservatives include preserving solutions and slurries, Jellies and pastes of organic colloids. Such preparations are widespread industrial use, for example in the textile, paper, leather, tobacco, wood and Straw processing, in the production of binders and adhesives, for printing materials, thickeners !!, Paints, dye suspensions, inks and protective agents containing hydrazine against the occurrence and multiplication

of microorganisms

Applicant:

Dr. Kurt Lindner,

Berlin-Lichterfelde 2, Mariannenstr. 46

also cosmetic preparations of various kinds.

Solutions, slurries, jellies and pastes are especially used against attack by microorganisms protected, which contain carbohydrates or proteins.

The effectiveness of the mixtures of hydrazine with surface-active compounds is directed against Bacteria as well as against fungal pests, especially molds. Enzyme development through Bacteria and fungi are inhibited, whereby the enzymatic breakdown of cellulose materials or Proteins is disrupted. Such bacteria also have an effect on the development of dirt and slime bacteria Mixtures in very small quantities. For example, one solution already succeeds in which contains 0.01% hydrazine hydrate and 0.15% sodium tetrapropylene benzene sulfonate, the formation to suppress such microorganisms.

The free hydrazine base also has a hydrotropic effect and is already in proportion small amounts enables both turbidity in the

φο aqueous concentrates of the surface-active Completely remove substances themselves, as they arise from the precipitation of poorly soluble components, as well as inherently insoluble compounds such as solvents, phenolic solids, organic acids, organic To bring heavy metal compounds or the like into solution in the overall system.

The essence of the invention will be explained in more detail by the following experiments.

A. A technical dodecylbenzene is sulfonated in a known manner with 125% of a 20% strength oleum. The crude sulfonic acid is also better known after the approximately 78% waste sulfuric acid has been separated off Way neutralized with sodium hydroxide solution and a 3O% sodium dodecylbenzenesulfonate with a

909 628/342

adjusted _pH value of about 7.5. The result is a light yellow, viscous preparation of a cloudy nature, which separates out solid portions of long-chain dodecylbenzenesulfonates when left standing for a long time.

B. In the manner described under A, a preparation with 34.3% sodium dodecylbenzenesulfonate produced, which even stronger cloudiness and deposition phenomena than the 30% product. 87.5 parts of this preparation are with 12.5 parts of hydrazine hydrate (80%) were carefully stirred, gradually becoming completely clear of the product occurs. The result is a clear, yellow and viscous liquid, which in turn is 30% technical Contains sodium alkylbenzenesulfonate and also 10% hydrazine hydrate (100%). The preparation can be kept for months without the formation of deposits or cloudiness.

Preservation attempts

A 30% gelatin jelly was made in a non-sterile Working room, which had an average temperature of 20 to 22 ° C, was exposed to the in This room is placed on the existing germs, with a temperature increase overnight after 3 days took place at 35 ° C. After 14 days, the jelly was due to mold and putrefactive bacteria completely decomposed and liquefied.

50 ml each of a freshly prepared 3% gelatin solution was placed in Petri dishes and each time with it 0.5 ml of the putrid and liquefied jelly, the preparation of which has been described above, inoculated and Mix well with or without an anti-germ additive and finally left to solidify.

Then the Petri dishes with the solidified gelatin jelly at average temperatures of 20 Stored up to 22 ° C and observed for 7 weeks.

The test without addition showed after 3 days

the first appearance of mold. After 19 days this jelly was completely liquefied and in

ίο putrefaction passed.

The other gelatin solutions were inoculated with the following preparations:

Preparation A = sodium alkylbenzenesulfonate (30%) Preparation B = 30% sodium alkylbenzenesulfonate + 10% hydrazine hydrate preparation C = hydrazine hydrate (10%).

Preparations A and B were produced as described above. Preparation C was made by diluting an 80% hydrazine hydrate produced commercially.

The added amounts of the three preparations were 0.5 and 0.1%, based on the volume of the gelatin solution before solidification. As in the experiment without addition, the first occurrence of Observed mold and then complete liquefaction. The latter was of a strong demeanor accompanied by putrefactive bacteria and corresponding odor formation.

The table below shows the results:

A. 0.5%
preparation
B. C. A. 0.1 0/0
preparation
B. C. Number of days to
for the first appearance of
Molds ... .... 7th
26th - 25th 3
20th 26th 12th
40 to putrefaction and utter
liquefaction

So while the sodium alkylbenzenesulfonate A has only a slight anti-germ behavior, can under the very unfavorable conditions of the experiment with 0.5% of the invention Mixture B, the jelly can be kept from mold and rot for 7 weeks. Even the A 0.1% additive results in a low occurrence of mold, but it actually turned into rot and liquefaction not observed. With hydrazine hydrate in the appropriate amount, these are observed germ-resistant effects considerably weaker, so that at the high concentration mold formation without Putrefaction and, in the case of the lower concentration, rapid mold formation and putrefaction with complete liquefaction was to be determined.

The synergistic effect of the mixture according to the invention becomes clear in these experiments.

In addition to water and the organic solvents already mentioned for hydrazine, the the above-described mixtures also together with other salts or inert substances or in suspensions with organic solvents such as hydrogenated phenols, dioxane, glycol ethers or hydrocarbons, come into use.

It is known per se and are not the subject of this invention that the free U Hydrazinbase fungicidal already in the form of their aqueous solutions without any further additives, and has bactericidal effects. The use of such hydrazine hydrate solutions is hardly possible commercially because of their caustic and toxic properties. In contrast, the method described above is a commercially possible form of application, since the hydrazine is only used very diluted and, due to the synergistic effects of the combinations with surface-active substances and possibly the other bactericidal or bacteriostatic active ingredients, is effective in much smaller amounts than in the absence of these additives is.

Claims (5)

Patent claims: 1. Protective agent against the appearance and reproduction of microorganisms with a content of hydrazine, characterized in that, in addition to hydrazine, it also contains surface-active compounds contains, which in itself has little or no protective effect against microorganisms own. 2. Protection means according to claim 1, characterized in that there are also other per se 5 6 contains known protective agents against the formation and dissolution of the active ingredients in organic dissolution of microorganisms. funds is available. 3. Protection means according to claim 1 and 2, there- characterized in that it is in the form of a aqueous solution of the active ingredients is present. 5 Considered publications: 4. Protective agent according to claim 1 and 2, since Kirk-Othmer, Encyclopedia of Chemical Tech characterized as being in the form of a nology, Vol. 2, 1948, p. 79. © 909 628/342 9. 59