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DD210687A5 - Verfahren zur herstellung von (+)-cyanidan-3-ol-derivaten - Google Patents

Verfahren zur herstellung von (+)-cyanidan-3-ol-derivaten Download PDF

Info

Publication number
DD210687A5
DD210687A5 DD83251542A DD25154283A DD210687A5 DD 210687 A5 DD210687 A5 DD 210687A5 DD 83251542 A DD83251542 A DD 83251542A DD 25154283 A DD25154283 A DD 25154283A DD 210687 A5 DD210687 A5 DD 210687A5
Authority
DD
German Democratic Republic
Prior art keywords
compounds
formula
hydrogen
benzyl
item
Prior art date
Application number
DD83251542A
Other languages
German (de)
English (en)
Inventor
Marc E Ballenegger
Christian G Rimbault
Alban I Albert
Andre J Weith
Pierre Courbat
Robert G Tyson
Derek R Palmer
David G Thompson
Original Assignee
Zyma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zyma Sa filed Critical Zyma Sa
Publication of DD210687A5 publication Critical patent/DD210687A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
DD83251542A 1982-06-01 1983-05-31 Verfahren zur herstellung von (+)-cyanidan-3-ol-derivaten DD210687A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8215867 1982-06-01

Publications (1)

Publication Number Publication Date
DD210687A5 true DD210687A5 (de) 1984-06-20

Family

ID=10530750

Family Applications (1)

Application Number Title Priority Date Filing Date
DD83251542A DD210687A5 (de) 1982-06-01 1983-05-31 Verfahren zur herstellung von (+)-cyanidan-3-ol-derivaten

Country Status (19)

Country Link
US (1) US4644011A (es)
EP (1) EP0096007B1 (es)
JP (1) JPS58219177A (es)
KR (1) KR840005124A (es)
AT (1) ATE28641T1 (es)
AU (1) AU568301B2 (es)
CA (1) CA1234103A (es)
DD (1) DD210687A5 (es)
DE (1) DE3372764D1 (es)
DK (1) DK245283A (es)
ES (2) ES8507533A1 (es)
FI (1) FI831926A7 (es)
GB (1) GB2122608B (es)
GR (1) GR78346B (es)
IL (1) IL68832A (es)
NO (1) NO831950L (es)
NZ (1) NZ204422A (es)
PT (1) PT76782B (es)
ZA (1) ZA833908B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141745A (en) * 1986-03-27 1992-08-25 The Lubrizol Corporation Nodulation inducing factors
US4743694A (en) * 1986-04-11 1988-05-10 Mercek & Co., Inc. Diastereocontrolled synthesis of 2-amino alcohols
US4898890A (en) * 1986-06-21 1990-02-06 Dainippon Ink And Chemicals, Inc. Medicines for use in the therapy and prevention of kidney and liver diseases
US6207842B1 (en) 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US6156912A (en) * 1999-04-09 2000-12-05 Mars, Incorporated 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation
US7015338B1 (en) 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
NL1016815C2 (nl) * 1999-12-15 2002-05-14 Ciba Sc Holding Ag Oximester-fotoinitiatoren.
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
US7067679B2 (en) 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest
US20070004796A1 (en) * 2005-06-29 2007-01-04 Romanczyk Leo Jr Processes for the preparation of protected-(+)-catechin and (-)-epicatechin monomers, for coupling the protected monomers with an activated, protected epicatechin monomer, and for the preparation of epicatechin-(4B,8)-epicatechin or -catechin dimers and their digallates
US20130202545A1 (en) * 2010-04-12 2013-08-08 Berkem S.A. Stablised Polyphenol Derivatives, Process for Their Manufacture, and Uses Thereof
EP2668176B1 (en) * 2011-01-27 2017-05-17 Sphaera Pharma Pte. Ltd A novel process for synthesis of polyphenols
CN106518802B (zh) * 2016-11-17 2018-11-09 山东铂源药业有限公司 一种2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-甲酸乙酯的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575004A (en) * 1976-03-23 1980-09-17 Iverni Della Beffa Spa Pharmacologically active polyphenolic substances
US4255336A (en) * 1977-11-25 1981-03-10 Ciba-Geigy Corporation Process for the preparation of O-substituted derivatives of (+)-cyanidan-3-01
DE3176349D1 (en) * 1980-04-03 1987-09-17 Zyma Sa Use of o-substituted derivatives of (+)-cyanidanol-3 as compounds with immunomodulative properties

Also Published As

Publication number Publication date
CA1234103A (en) 1988-03-15
PT76782A (en) 1983-06-01
ES522814A0 (es) 1985-09-16
FI831926A0 (fi) 1983-05-30
KR840005124A (ko) 1984-11-03
PT76782B (en) 1986-05-20
NZ204422A (en) 1986-09-10
IL68832A (en) 1988-06-30
EP0096007A2 (en) 1983-12-07
EP0096007B1 (en) 1987-07-29
ATE28641T1 (de) 1987-08-15
FI831926L (fi) 1983-12-02
US4644011A (en) 1987-02-17
EP0096007A3 (en) 1984-01-04
AU568301B2 (en) 1987-12-24
NO831950L (no) 1983-12-02
ES8507533A1 (es) 1985-09-16
DK245283D0 (da) 1983-05-31
GB2122608B (en) 1985-10-02
ZA833908B (en) 1984-01-25
DE3372764D1 (en) 1987-09-03
IL68832A0 (en) 1983-09-30
AU1525583A (en) 1983-12-08
GB8312765D0 (en) 1983-06-15
ES536423A0 (es) 1987-04-16
GR78346B (es) 1984-09-26
DK245283A (da) 1983-12-02
ES8704919A1 (es) 1987-04-16
JPS58219177A (ja) 1983-12-20
FI831926A7 (fi) 1983-12-02
GB2122608A (en) 1984-01-18

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