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CZ203295A3 - N-alkyl-2-substituted adenosinetriphosphate derivatives, process of their preparation and a pharmaceutical composition containing thereof - Google Patents

N-alkyl-2-substituted adenosinetriphosphate derivatives, process of their preparation and a pharmaceutical composition containing thereof

Info

Publication number
CZ203295A3
CZ203295A3 CZ952032A CZ203295A CZ203295A3 CZ 203295 A3 CZ203295 A3 CZ 203295A3 CZ 952032 A CZ952032 A CZ 952032A CZ 203295 A CZ203295 A CZ 203295A CZ 203295 A3 CZ203295 A3 CZ 203295A3
Authority
CZ
Czechia
Prior art keywords
alkyl
adenosinetriphosphate
derivatives
substituted
preparation
Prior art date
Application number
CZ952032A
Other languages
English (en)
Other versions
CZ286050B6 (cs
Inventor
Anthony Howard Ingall
Peter Alan Cage
Nicholas David Kindon
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939302636A external-priority patent/GB9302636D0/en
Priority claimed from GB939325712A external-priority patent/GB9325712D0/en
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Publication of CZ203295A3 publication Critical patent/CZ203295A3/cs
Publication of CZ286050B6 publication Critical patent/CZ286050B6/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CZ952032A 1993-02-10 1994-02-08 N-Alkyl-2-substituované adenosintrifostátové deriváty, způsob jejich přípravy a farmaceutické kompozice tyto deriváty obsahující CZ286050B6 (cs)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939302636A GB9302636D0 (en) 1993-02-10 1993-02-10 Compounds
GB939325712A GB9325712D0 (en) 1993-12-16 1993-12-16 Compounds
PCT/GB1994/000237 WO1994018216A1 (en) 1993-02-10 1994-02-08 N-alkyl-2-substituted atp analogues

Publications (2)

Publication Number Publication Date
CZ203295A3 true CZ203295A3 (en) 1995-12-13
CZ286050B6 CZ286050B6 (cs) 1999-12-15

Family

ID=26302434

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ952032A CZ286050B6 (cs) 1993-02-10 1994-02-08 N-Alkyl-2-substituované adenosintrifostátové deriváty, způsob jejich přípravy a farmaceutické kompozice tyto deriváty obsahující

Country Status (25)

Country Link
US (2) US5721219A (cs)
EP (1) EP0683789B1 (cs)
JP (1) JP3083156B2 (cs)
KR (1) KR100315612B1 (cs)
CN (1) CN1042430C (cs)
AT (1) ATE159950T1 (cs)
AU (1) AU679721B2 (cs)
CA (1) CA2155673C (cs)
CZ (1) CZ286050B6 (cs)
DE (1) DE69406649T2 (cs)
DK (1) DK0683789T3 (cs)
ES (1) ES2108425T3 (cs)
FI (1) FI110687B (cs)
GR (1) GR3025995T3 (cs)
HU (1) HU221501B (cs)
IL (1) IL108602A (cs)
NO (1) NO305209B1 (cs)
NZ (1) NZ261159A (cs)
PL (1) PL175623B1 (cs)
RU (1) RU2136693C1 (cs)
SG (1) SG47943A1 (cs)
SK (1) SK281309B6 (cs)
TW (1) TW326045B (cs)
UA (1) UA54366C2 (cs)
WO (1) WO1994018216A1 (cs)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK281309B6 (sk) * 1993-02-10 2001-02-12 Astra Pharmaceuticals Limited N-alkyl-2-substituované adenozíntrifosfátové deriváty, spôsob ich prípravy, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov
CA2241687A1 (en) * 1996-10-30 1998-05-07 Kenneth A. Jacobson P2y receptor antagonists
SE9604795D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Prod New pharmaceutical formulation
US6686462B2 (en) * 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
SE9702680D0 (sv) * 1997-07-11 1997-07-11 Astra Pharma Prod New formulation
AU2003257524B2 (en) * 1997-07-11 2006-04-06 Astrazeneca Ab New formulation
FI104901B (fi) * 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US7598246B2 (en) * 1998-04-02 2009-10-06 Mbc Pharma, Inc. Bisphosphonate conjugates and methods of making and using the same
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
US6750340B2 (en) * 1998-04-02 2004-06-15 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US6303774B1 (en) 1999-08-20 2001-10-16 Sri International Nucleoside pyrophosphate and triphosphate analogs and related compounds
SE9903345D0 (sv) 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
AR039558A1 (es) * 2000-08-21 2005-02-23 Inspire Pharmaceuticals Inc Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US7115585B2 (en) 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7452870B2 (en) 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7435724B2 (en) 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
RU2004128943A (ru) * 2002-02-28 2005-04-20 Байота, Инк. (Us) Средства, имитирующие нуклеотиды, и их пролекарственные формы
BR0312778A (pt) * 2002-07-18 2005-05-03 Sankyo Co Composição farmacêutica para prevenção ou tratamento de arteriosclerose ou doenças derivadas de arteriosclerose, e, usos de um antagonista de receptor de adp e de um inibidor de acat
US20050192245A1 (en) * 2002-07-18 2005-09-01 Sankyo Company, Limited Medicinal composition for treating arteriosclerosis
CN1713926B (zh) * 2002-11-21 2010-12-22 兴和株式会社 腹膜透析法
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
EP1604669A1 (en) * 2004-06-10 2005-12-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of ATP analogues for treatment of cardiovascular diseases
WO2009140092A1 (en) 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US8759316B2 (en) * 2008-05-13 2014-06-24 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
US20120141468A1 (en) 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
US20130303477A1 (en) * 2008-05-13 2013-11-14 The Medicines Company Maintenance of Platelet Inhibition During Antiplatelet Therapy
HRP20200445T1 (hr) 2009-11-11 2020-06-12 Chiesi Farmaceutici S.P.A. Metode liječenja ili prevencije tromboze u stentu
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
WO2012100654A1 (zh) 2011-01-26 2012-08-02 北京化工大学 呋喃核糖基嘌呤类化合物及其制备方法和应用
CN103582480B (zh) * 2011-02-09 2016-03-16 医药公司 治疗肺高压的方法
US9334300B2 (en) 2011-08-01 2016-05-10 Mbc Pharma, Inc. Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
CN115120606A (zh) 2013-03-09 2022-09-30 奇斯药制品公司 治疗局部缺血事件、减少局部缺血事件的发生和/或预防局部缺血事件的方法
CN104447928A (zh) * 2013-09-13 2015-03-25 天津市汉康医药生物技术有限公司 坎格雷洛二水化合物
CN104447927A (zh) * 2013-09-13 2015-03-25 天津市汉康医药生物技术有限公司 坎格雷洛一水合物晶体及其制备方法
CN103772461A (zh) * 2014-01-06 2014-05-07 南京正科制药有限公司 一种坎格雷洛晶型ⅰ
CA2937548C (en) 2014-02-13 2022-10-25 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
WO2016003812A1 (en) 2014-07-02 2016-01-07 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
CN105273025B (zh) * 2014-07-22 2019-07-26 上海医药工业研究院 一种制备坎格雷洛的中间体及其制备方法和应用
MX391152B (es) 2015-01-14 2025-03-21 Chiesi Farm Spa Formulaciones farmaceuticas que comprenden cangrelor de alta pureza y metodos para preparar y utilizar las mismas.
CN105061431B (zh) * 2015-07-28 2017-03-29 山东百诺医药股份有限公司 6‑n‑（2‑（甲硫基）乙基）‑2‑（（3,3,3‑三氟丙基）硫代）‑9h‑嘌呤及其制备方法和应用
CN107001405B (zh) * 2015-11-06 2019-03-05 江苏恒瑞医药股份有限公司 制备坎格雷洛中间体的方法
CN107973832B (zh) * 2016-10-25 2021-11-12 上海医药工业研究院 6-n-[2-(甲硫基)乙基]-2-[(3，3，3-三氟丙基)硫代]腺苷的制法
CN107973798B (zh) * 2016-10-25 2020-04-24 上海医药工业研究院 2-[(3,3,3-三氟丙基)硫代]-6-氨基-9h-嘌呤及制法
CN106674322B (zh) * 2016-12-07 2019-04-16 上海博志研新药物技术有限公司 一种坎格雷洛中间体的纯化方法
WO2018185715A1 (en) * 2017-04-06 2018-10-11 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of n6-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5'-adenylic acid, monoanhydride with (dichloromethylene) bisphosphonic acid and its pharmaceutically acceptable salts
CN110740736A (zh) 2017-06-23 2020-01-31 奇斯药制品公司 预防体-肺动脉分流术血栓形成的方法
US11279724B2 (en) 2017-11-10 2022-03-22 Olon S.P.A. Efficient method for the preparation of Cangrelor
CN109912674A (zh) * 2017-12-12 2019-06-21 亚宝药业集团股份有限公司 一种坎格雷洛四钠盐的制备方法
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
US20190241606A1 (en) * 2018-02-05 2019-08-08 Scinopharm Taiwan, Ltd. Process for preparation of cangrelor tetrasodium and intermediate therefor
CN108033983B (zh) * 2018-02-09 2021-06-08 盐城锦明药业有限公司 一种2‐(3,3,3‐三氟丙基)硫代腺苷的合成方法
EP4289435A1 (en) 2022-06-07 2023-12-13 Université de Liège N-alkyl-2-substituted atp analogues for use as antibacterial agent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU764326A1 (ru) * 1977-11-16 1982-09-23 Ордена Ленина Институт Химической Физики Ан Ссср Способ получени спин-меченого производного аденозинтрифосфата
US5049550A (en) * 1987-11-05 1991-09-17 Worcester Foundation For Experimental Biology Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents
CA2049977A1 (en) * 1989-03-24 1990-09-25 Hirofumi Kitaoka Nootropic agent
GB9107236D0 (en) 1991-04-06 1991-05-22 Fisons Plc Compounds
HUT64967A (en) * 1991-04-06 1994-03-28 Fisons Plc Atp analogues and pharmaceutical compositions containing them
SK281309B6 (sk) * 1993-02-10 2001-02-12 Astra Pharmaceuticals Limited N-alkyl-2-substituované adenozíntrifosfátové deriváty, spôsob ich prípravy, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov

Also Published As

Publication number Publication date
CN1119869A (zh) 1996-04-03
NO305209B1 (no) 1999-04-19
PL310160A1 (en) 1995-11-27
RU2136693C1 (ru) 1999-09-10
WO1994018216A1 (en) 1994-08-18
AU679721B2 (en) 1997-07-10
EP0683789A1 (en) 1995-11-29
HUT72464A (en) 1996-04-29
CZ286050B6 (cs) 1999-12-15
JP3083156B2 (ja) 2000-09-04
JPH08506335A (ja) 1996-07-09
DE69406649D1 (de) 1997-12-11
EP0683789B1 (en) 1997-11-05
HK1002936A1 (en) 1998-09-25
UA54366C2 (uk) 2003-03-17
ATE159950T1 (de) 1997-11-15
CA2155673C (en) 2004-08-17
DK0683789T3 (da) 1998-02-09
IL108602A0 (en) 1994-05-30
DE69406649T2 (de) 1998-03-05
CN1042430C (zh) 1999-03-10
SK281309B6 (sk) 2001-02-12
FI953794A0 (fi) 1995-08-10
IL108602A (en) 1999-12-22
NO953126L (no) 1995-09-28
TW326045B (en) 1998-02-01
SK99495A3 (en) 1996-02-07
PL175623B1 (pl) 1999-01-29
NO953126D0 (no) 1995-08-09
SG47943A1 (en) 1998-04-17
FI110687B (fi) 2003-03-14
ES2108425T3 (es) 1997-12-16
AU5977094A (en) 1994-08-29
NZ261159A (en) 1997-06-24
FI953794L (fi) 1995-08-10
US5955447A (en) 1999-09-21
HU221501B (en) 2002-10-28
CA2155673A1 (en) 1994-08-18
US5721219A (en) 1998-02-24
KR100315612B1 (ko) 2002-06-20
GR3025995T3 (en) 1998-04-30

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20050208