CZ20023213A3 - Benzoamidové piperidinové sloučeniny a příbuzné sloučeniny - Google Patents

Info

Publication number

CZ20023213A3

CZ20023213A3 CZ20023213A CZ20023213A CZ20023213A3 CZ 20023213 A3 CZ20023213 A3 CZ 20023213A3 CZ 20023213 A CZ20023213 A CZ 20023213A CZ 20023213 A CZ20023213 A CZ 20023213A CZ 20023213 A3 CZ20023213 A3 CZ 20023213A3

Authority

CZ

Czechia

Prior art keywords

methyl

methoxy

ylamino

phenylpiperidin

phenyl

Prior art date

2000-04-10

Links

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 384
• NXUSCSCBRVCRCN-UHFFFAOYSA-N benzamide;piperidine Chemical class C1CCNCC1.NC(=O)C1=CC=CC=C1 NXUSCSCBRVCRCN-UHFFFAOYSA-N 0.000 title abstract description 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 127
• 208000035475 disorder Diseases 0.000 claims abstract description 111
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• 241000590002 Helicobacter pylori Species 0.000 claims abstract description 6
• 230000033115 angiogenesis Effects 0.000 claims abstract description 6
• 229940037467 helicobacter pylori Drugs 0.000 claims abstract description 6
• 208000027866 inflammatory disease Diseases 0.000 claims abstract description 4
• -1 hydroxy, thioxo Chemical group 0.000 claims description 233
• 150000003839 salts Chemical class 0.000 claims description 127
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 122
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 92
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 82
• 125000001424 substituent group Chemical group 0.000 claims description 79
• 125000001153 fluoro group Chemical group F* 0.000 claims description 76
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 75
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 73
• 229910052739 hydrogen Inorganic materials 0.000 claims description 67
• 239000001257 hydrogen Substances 0.000 claims description 67
• WZCKOKPKQZIGNU-UHFFFAOYSA-N 1h-naphthalen-2-one Chemical compound C1=CC=C2C=CC(=O)CC2=C1 WZCKOKPKQZIGNU-UHFFFAOYSA-N 0.000 claims description 61
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 59
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 59
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 56
• 229910052736 halogen Inorganic materials 0.000 claims description 55
• 125000004432 carbon atom Chemical group C* 0.000 claims description 51
• 125000000623 heterocyclic group Chemical group 0.000 claims description 51
• 150000002367 halogens Chemical class 0.000 claims description 47
• 238000000034 method Methods 0.000 claims description 47
• 229910052757 nitrogen Inorganic materials 0.000 claims description 46
• 241000124008 Mammalia Species 0.000 claims description 41
• 125000000217 alkyl group Chemical group 0.000 claims description 41
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• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 21
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