CZ20012891A3 - Příprava jodixanolu - Google Patents

Příprava jodixanolu

Info

Publication number: CZ20012891A3
Authority: CZ; Czechia
Prior art keywords: iodixanol; dimerisation; compound; preparing iodixanol; preparing
Prior art date: 1999-02-11

Application number

CZ20012891A

Other languages

English (en)

Other versions

CZ296353B6 (cs

Inventor

Ole Magne Homestad

Original Assignee

Nycomed Imaging As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-11

Filing date

2000-02-10

Publication date

2001-12-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CZ20012891(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-02-10 Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As

2001-12-12 Publication of CZ20012891A3 publication Critical patent/CZ20012891A3/cs

2006-02-15 Publication of CZ296353B6 publication Critical patent/CZ296353B6/cs

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Compounds Of Unknown Constitution (AREA)

CZ20012891A 1999-02-11 2000-02-10 Príprava jodixanolu CZ296353B6 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9903109.8A GB9903109D0 (en)	1999-02-11	1999-02-11	Process

Publications (2)

Publication Number	Publication Date
CZ20012891A3 true CZ20012891A3 (cs)	2001-12-12
CZ296353B6 CZ296353B6 (cs)	2006-02-15

Family

ID=10847565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ20012891A CZ296353B6 (cs)	1999-02-11	2000-02-10	Príprava jodixanolu

Country Status (18)

Country	Link
US (8)	US6974882B2 (cs)
EP (1)	EP1150943B1 (cs)
JP (1)	JP4545945B2 (cs)
KR (1)	KR100625139B1 (cs)
CN (1)	CN1178899C (cs)
AT (1)	ATE249420T1 (cs)
AU (1)	AU2449500A (cs)
CA (1)	CA2356942C (cs)
CZ (1)	CZ296353B6 (cs)
DE (1)	DE60005143T2 (cs)
ES (1)	ES2206190T3 (cs)
GB (1)	GB9903109D0 (cs)
HU (1)	HU228226B1 (cs)
IL (1)	IL143969A0 (cs)
NO (1)	NO329363B1 (cs)
PL (1)	PL197893B1 (cs)
PT (1)	PT1150943E (cs)
WO (1)	WO2000047549A1 (cs)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100574087B1 (ko)	2004-09-09	2006-04-27	주식회사태준제약	아이오디사놀의 제조방법
KR100700701B1 (ko) *	2004-10-28	2007-03-28	동국정밀화학(주)	이오딕사놀의 제조방법
NO20053687D0 (no) *	2005-07-29	2005-07-29	Amersham Health As	Crystallisation Process.
NO20055702D0 (no) *	2005-12-02	2005-12-02	Amersham Health As	Contrast agents
US20070148096A1 (en) *	2005-12-15	2007-06-28	Lars-Goran Wistrand	Contrast Agents
EP1966110B1 (en)	2005-12-19	2013-04-24	Ge Healthcare As	Purification process of iodixanol
CN101195587B (zh) *	2006-12-19	2010-07-21	浙江尖峰海洲制药有限公司	一种碘克沙醇水解物的制备方法
CN101293855B (zh) *	2007-04-27	2012-08-29	上海冠杰生物医药科技有限公司	一种碘克沙醇的纯化方法
CN103951586B (zh) *	2007-07-12	2015-05-27	通用电气医疗集团股份有限公司	造影剂
ES2650800T5 (en)	2007-07-19	2025-05-05	Medical Components Inc	Venous access port assembly with x-ray discernable indicia
US8962886B2 (en) *	2009-07-21	2015-02-24	Ge Healthcare As	Synthesis of iodixanol in methanol
US20110020238A1 (en)	2009-07-21	2011-01-27	Ge Healthcare As	Stabilizing aqueous solution of iodine chloride by adding sodium chloride
US20110021833A1 (en)	2009-07-21	2011-01-27	Ge Healthcare As	Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US7696381B1 (en) *	2009-07-21	2010-04-13	Ge Healthcare As	Alternative dimerisation reagents for synthesis of iodixanol
US8962887B2 (en) *	2009-07-21	2015-02-24	Ge Healthcare As	Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US8969619B2 (en) *	2009-07-21	2015-03-03	Ge Healthcare As	Synthesis of iodixanol in propyleneglycol
US7999134B2 (en)	2009-07-21	2011-08-16	Ge Healthcare As	Crystallization of iodixanol using milling
US20110021828A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
US7999135B2 (en)	2009-07-21	2011-08-16	Ge Healthcare As	Crystallization of iodixanol using ultrasound
US7754920B1 (en) *	2009-07-21	2010-07-13	Ge Healthcare As	Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US20110021822A1 (en)	2009-07-21	2011-01-27	Ge Healthcare As	continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021821A1 (en)	2009-07-21	2011-01-27	Ge Healthcare As	Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US20110021823A1 (en)	2009-07-21	2011-01-27	Ge Healthcare As	Processing crude iodixanol mixture by nanofiltration
US20110021825A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Process for isolating iodixanol from an aqueous solution
US20110021832A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Synthesis of iodixanol in water
US8461600B2 (en) *	2009-09-11	2013-06-11	Ut-Battelle, Llc	Method for morphological control and encapsulation of materials for electronics and energy applications
PT2504298T (pt) *	2009-11-26	2016-12-29	Imax Diagnostic Imaging Holding Ltd	Preparação e purificação de iodoxanol
CN102079716B (zh) *	2009-11-26	2014-03-05	浙江台州海神制药有限公司	碘克沙醇的制备与纯化
ES2680019T3 (es)	2010-12-21	2018-09-03	Ge Healthcare As	Desalinización de una composición que comprende un agente de contraste
CN103058880B (zh) *	2011-10-21	2015-08-05	连云港润众制药有限公司	碘克沙醇及其合成中间体的制备方法
US9884808B2 (en) *	2012-09-27	2018-02-06	Ge Healthcare As	Preparation of an intermediate compound of ioforminol
CN102875411A (zh) *	2012-10-30	2013-01-16	广州牌牌生物科技有限公司	一种用大孔树脂分离纯化碘克沙醇注射剂原料的方法
EP2917174B1 (en) *	2012-11-12	2018-09-12	Ge Healthcare As	Preparation of intermediates of x-ray contrast agents
CN103265449A (zh) *	2013-05-30	2013-08-28	四川铂瑞生物医药有限公司	5-氨基-2,4,6-三碘-n,n’-双(2,3-二羟基丙基)-1,3-苯二甲酰胺的合成
WO2015082720A1 (en)	2013-12-06	2015-06-11	Ge Healthcare As	Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
CN113831256B (zh) *	2021-09-17	2024-06-11	江苏宇田医药有限公司	一种碘克沙醇的中间体及其制备碘克沙醇的方法

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US3816521A (en)	1967-10-02	1974-06-11	Ueno Pharm Co Ltd	Process for the production of p-hydroxy benzoic acid
ATE20733T1 (de) *	1982-11-08	1986-08-15	Nyegaard & Co As	Roentgenkontrastmittel.
US5235116A (en)	1992-08-24	1993-08-10	Eastman Kodak Company	Process for the preparation of 2-(1-phenylethyl)hydroquinone and 2-(1-phenylethyl)hydroquinone diacetate
GB9618055D0 (en)	1996-08-29	1996-10-09	Nycomed Imaging As	Process
GB9624612D0 (en) *	1996-11-26	1997-01-15	Nycomed Imaging As	Process

1999
- 1999-02-11 GB GBGB9903109.8A patent/GB9903109D0/en not_active Ceased
2000
- 2000-02-10 CN CNB008037051A patent/CN1178899C/zh not_active Expired - Lifetime
- 2000-02-10 PL PL348857A patent/PL197893B1/pl unknown
- 2000-02-10 AU AU24495/00A patent/AU2449500A/en not_active Abandoned
- 2000-02-10 CZ CZ20012891A patent/CZ296353B6/cs not_active IP Right Cessation
- 2000-02-10 HU HU0105096A patent/HU228226B1/hu unknown
- 2000-02-10 AT AT00902754T patent/ATE249420T1/de not_active IP Right Cessation
- 2000-02-10 EP EP00902754A patent/EP1150943B1/en not_active Expired - Lifetime
- 2000-02-10 DE DE60005143T patent/DE60005143T2/de not_active Expired - Lifetime
- 2000-02-10 PT PT00902754T patent/PT1150943E/pt unknown
- 2000-02-10 IL IL14396900A patent/IL143969A0/xx not_active IP Right Cessation
- 2000-02-10 KR KR1020017010055A patent/KR100625139B1/ko not_active Expired - Lifetime
- 2000-02-10 WO PCT/GB2000/000413 patent/WO2000047549A1/en not_active Ceased
- 2000-02-10 CA CA002356942A patent/CA2356942C/en not_active Expired - Lifetime
- 2000-02-10 JP JP2000598470A patent/JP4545945B2/ja not_active Expired - Lifetime
- 2000-02-10 ES ES00902754T patent/ES2206190T3/es not_active Expired - Lifetime
2001
- 2001-08-06 US US09/923,074 patent/US6974882B2/en not_active Expired - Lifetime
- 2001-08-09 NO NO20013881A patent/NO329363B1/no not_active IP Right Cessation
2005
- 2005-11-28 US US11/288,029 patent/US20060137602A1/en not_active Abandoned
2007
- 2007-03-01 US US11/680,716 patent/US20070203362A1/en not_active Abandoned
- 2007-12-18 US US11/958,714 patent/US20080161606A1/en not_active Abandoned
2008
- 2008-10-06 US US12/245,886 patent/US20090112022A1/en not_active Abandoned
2009
- 2009-08-24 US US12/545,884 patent/US20100069669A1/en not_active Abandoned
2010
- 2010-08-24 US US12/862,023 patent/US20110207963A1/en not_active Abandoned
2011
- 2011-10-06 US US13/267,133 patent/US20120083625A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1150943B1 (en)	2003-09-10
CA2356942C (en)	2008-09-02
US20020010368A1 (en)	2002-01-24
US20070203362A1 (en)	2007-08-30
ATE249420T1 (de)	2003-09-15
NO20013881D0 (no)	2001-08-09
HUP0105096A2 (hu)	2002-04-29
PL348857A1 (en)	2002-06-17
US20080161606A1 (en)	2008-07-03
ES2206190T3 (es)	2004-05-16
IL143969A0 (en)	2002-04-21
NO329363B1 (no)	2010-10-04
US20110207963A1 (en)	2011-08-25
US20100069669A1 (en)	2010-03-18
CN1178899C (zh)	2004-12-08
HU228226B1 (en)	2013-02-28
KR20010102005A (ko)	2001-11-15
KR100625139B1 (ko)	2006-09-20
JP2002536429A (ja)	2002-10-29
US20090112022A1 (en)	2009-04-30
AU2449500A (en)	2000-08-29
WO2000047549A1 (en)	2000-08-17
DE60005143T2 (de)	2004-07-08
NO20013881L (no)	2001-08-09
US20060137602A1 (en)	2006-06-29
PT1150943E (pt)	2004-02-27
DE60005143D1 (de)	2003-10-16
PL197893B1 (pl)	2008-05-30
CZ296353B6 (cs)	2006-02-15
US6974882B2 (en)	2005-12-13
CN1340042A (zh)	2002-03-13
CA2356942A1 (en)	2000-08-17
HUP0105096A3 (en)	2004-05-28
GB9903109D0 (en)	1999-04-07
JP4545945B2 (ja)	2010-09-15
EP1150943A1 (en)	2001-11-07
US20120083625A1 (en)	2012-04-05

Publication	Publication Date	Title
CZ20012891A3 (cs)	2001-12-12	Příprava jodixanolu
PT1105466E (pt)	2006-07-31	Processo para a purificacao de particulas tipo virus do papilomavirus humano
JO2243B1 (en)	2004-10-07	Prepare a 6.3-dicyl-6.5-dihydro-4 hydroxy-pyran-2-one compound
NZ334817A (en)	2000-09-29	Process for the manufacture of iohexol
ES8801242A1 (es)	1988-01-01	Un procedimiento para la preparacion de metanosulfonatos de dioxolano.
GR3001816T3 (en)	1992-11-23	Process for the preparation of thienylethyl amines, and dithienylethyl amines so obtained
DE69606601D1 (de)	2000-03-16	Verfahren zur herstellung von dicarbonsäure-dichlorid
NO980594D0 (no)	1998-02-11	Fremgangsmåte for rensingen av et intermediat i fremstillingen av iopamidol
IL146746A0 (en)	2002-07-25	New process for the purification of aldehyde impurities
FI960301A0 (fi)	1996-01-22	Nikkelitön hemoglobiini ja menetelmät sellaisen hemoglobiinin tuottamiseksi
LT2002103A (en)	2003-05-26	Method for the preparation of (e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamine (terbinafine)
WO1999018063A3 (en)	1999-06-24	Process for preparing a cyclic amino acid anticonvulsant compound
EP1063232A3 (en)	2001-03-07	Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives
Reddy et al.	1999	A Novel, Simple and Rapid Protocol For N-Protected-oxazolidine-5-ones
DE69919382D1 (de)	2004-09-16	Herstellung von 5-amino-isophthalamiden
HUP0400825A2 (hu)	2004-08-30	Eljárás amorf cilastatin nátrium előállítására
MX9700331A (es)	1997-05-31	Proceso mejorado para r(+)1,2,3,6-tetrahidro-4-fenil-1-[(3-fenil-3-ciclohexen-1-il)metil]pirid ina, un agente del sistema nervioso central.
SU1823972A3 (ru)	1996-04-27	Способ очистки рибоксина
CA2229470A1 (en)	1997-12-18	Process for the purification of an intermediate in the preparation of iopamidol
IT1212692B (it)	1989-11-30	Procedimento per la preparazione di 3,3'-o 3,4'-diammino-benzofenone.
ATE342280T1 (de)	2006-11-15	Menschliche promotoren des gaba b-rezeptors 1
SU1334658A1 (ru)	1995-10-10	Способ получения м-хлордифенилметилмочевины
RU94029205A (ru)	1996-08-20	Способ получения ароматических и гетероароматических бис-1,2-дикетонов
MX9703846A (es)	1998-06-30	Nuevos derivados de 10, 11-dihidro-10-oxo-5h-dibenz/b, f/azepina-5-carboxamida.

Legal Events

Date	Code	Title	Description
2020-02-19	MK4A	Patent expired	Effective date: 20200210