CZ114099A3 - 1,4-Disubstituované piperaziny - Google Patents
1,4-Disubstituované piperaziny Download PDFInfo
- Publication number
- CZ114099A3 CZ114099A3 CZ991140A CZ114099A CZ114099A3 CZ 114099 A3 CZ114099 A3 CZ 114099A3 CZ 991140 A CZ991140 A CZ 991140A CZ 114099 A CZ114099 A CZ 114099A CZ 114099 A3 CZ114099 A3 CZ 114099A3
- Authority
- CZ
- Czechia
- Prior art keywords
- dibenzo
- propyl
- dihydro
- piperazinyl
- mmol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
- C07C2603/78—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing seven-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK109096 | 1996-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ114099A3 true CZ114099A3 (cs) | 1999-09-15 |
Family
ID=8100883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ991140A CZ114099A3 (cs) | 1996-10-04 | 1997-10-02 | 1,4-Disubstituované piperaziny |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US5916889A (ru) |
| EP (1) | EP0934312B1 (ru) |
| JP (1) | JP2001502307A (ru) |
| KR (1) | KR20000048899A (ru) |
| CN (1) | CN1088459C (ru) |
| AT (1) | ATE234831T1 (ru) |
| AU (1) | AU740662B2 (ru) |
| BR (1) | BR9712196A (ru) |
| CA (1) | CA2267835A1 (ru) |
| CZ (1) | CZ114099A3 (ru) |
| DE (1) | DE69720021T2 (ru) |
| DK (1) | DK0934312T3 (ru) |
| ES (1) | ES2194217T3 (ru) |
| HU (1) | HUP0000090A3 (ru) |
| IL (1) | IL129123A (ru) |
| NO (1) | NO991565L (ru) |
| PL (1) | PL188338B1 (ru) |
| RU (1) | RU2188197C2 (ru) |
| WO (1) | WO1998015548A1 (ru) |
| ZA (1) | ZA978864B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9712202A (pt) * | 1996-10-04 | 1999-08-31 | Novo Nordisk As | Composto, processo para preparar o mesmo, composicão farmacêutica, processo para o tratamento de inflamacão neurogênica em um indivíduo em necessidade deste tratamento, e, uso do composto. |
| US6613905B1 (en) * | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| ATE274510T1 (de) | 1998-06-19 | 2004-09-15 | Chiron Corp | Glycogen synthase kinase 3 inhibitoren |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US20040038861A1 (en) * | 2001-11-26 | 2004-02-26 | Cooper Garth J. S. | Methods and compositions for normalizing lipid levels in mammalian tissues |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| RU2007110731A (ru) * | 2004-09-23 | 2008-10-27 | Редди Юс Терапевтикс | Новые соединения пиримидина, способ их получения и содержащие их композиции |
| FR2885616B1 (fr) * | 2005-05-12 | 2007-06-22 | Servier Lab | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2885615B1 (fr) * | 2005-05-12 | 2007-06-22 | Servier Lab | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| BRPI0618643A2 (pt) | 2005-11-09 | 2011-09-06 | Combinatorx Inc | composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso |
| ES2534589T3 (es) * | 2007-04-13 | 2015-04-24 | Southern Research Institute | Clomipramina como agente antiangiogénico |
| CN103086898B (zh) * | 2012-07-11 | 2015-04-08 | 山东道可化学有限公司 | 二苯胺或其环上取代的衍生物的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL102488C (ru) * | 1957-07-18 | |||
| GB1013901A (en) * | 1962-01-26 | 1965-12-22 | Kefalas As | Dihydroanthracene, dibenzocycloheptadiene and dibenzocycloheptatriene derivatives |
| FR88751E (ru) * | 1963-07-09 | 1967-06-07 | ||
| US3435073A (en) * | 1966-04-19 | 1969-03-25 | Colgate Palmolive Co | 5-(n-benzyl-n-lower alkylaminoalkylene)-5h-dibenzo(a,d)cycloheptenes |
| GB1347935A (en) * | 1971-04-10 | 1974-02-27 | Yoshitomi Pharmaceutical | Piperazine derivatives methods for their production and phar maceutical compositions containing them |
| FR2186249A1 (en) * | 1972-05-31 | 1974-01-11 | Synthelabo | Phenyl piperazinoalkyl (dihydro)dibenzazepines - antidepressants having low toxicity |
| HU174126B (hu) * | 1977-08-02 | 1979-11-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija novykh proizvodnykh dibenzo-kvadratnaja skobka-d,g-kvadratnaja skobka zakryta-kvadratnaja skobka-1,3,6-kvadratnaja skobka zakryta-dioksazocina |
| ES8502099A1 (es) * | 1983-08-02 | 1984-12-16 | Espanola Farma Therapeut | Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina. |
| US4994463A (en) * | 1987-12-14 | 1991-02-19 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic thromboxane A2 antagonists |
| IE68935B1 (en) * | 1990-06-22 | 1996-07-24 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use |
| US5347012A (en) * | 1990-06-22 | 1994-09-13 | Taisho Pharmaceutical Co., Ltd. | Naphthothiopyranone derivatives |
| MY113463A (en) * | 1994-01-04 | 2002-03-30 | Novo Nordisk As | Novel heterocyclic compounds |
| UA54385C2 (ru) * | 1995-04-07 | 2003-03-17 | Ново Нордіск А/С | N-замещенные азагетероциклические карбоновые кислоты и их эфиры, способ их получения, фармацевтическая композиция и способ лечения |
| CN1090629C (zh) * | 1995-09-19 | 2002-09-11 | 诺沃挪第克公司 | 新的杂环化合物 |
-
1997
- 1997-10-02 WO PCT/DK1997/000422 patent/WO1998015548A1/en not_active Ceased
- 1997-10-02 DK DK97941884T patent/DK0934312T3/da active
- 1997-10-02 AU AU43772/97A patent/AU740662B2/en not_active Ceased
- 1997-10-02 ES ES97941884T patent/ES2194217T3/es not_active Expired - Lifetime
- 1997-10-02 PL PL97332597A patent/PL188338B1/pl not_active IP Right Cessation
- 1997-10-02 IL IL12912397A patent/IL129123A/en not_active IP Right Cessation
- 1997-10-02 EP EP97941884A patent/EP0934312B1/en not_active Expired - Lifetime
- 1997-10-02 DE DE69720021T patent/DE69720021T2/de not_active Expired - Fee Related
- 1997-10-02 AT AT97941884T patent/ATE234831T1/de not_active IP Right Cessation
- 1997-10-02 KR KR1019990702928A patent/KR20000048899A/ko not_active Ceased
- 1997-10-02 JP JP10517093A patent/JP2001502307A/ja not_active Ceased
- 1997-10-02 CZ CZ991140A patent/CZ114099A3/cs unknown
- 1997-10-02 HU HU0000090A patent/HUP0000090A3/hu unknown
- 1997-10-02 CN CN97199184A patent/CN1088459C/zh not_active Expired - Fee Related
- 1997-10-02 CA CA002267835A patent/CA2267835A1/en not_active Abandoned
- 1997-10-02 BR BR9712196-7A patent/BR9712196A/pt not_active IP Right Cessation
- 1997-10-02 RU RU99109024/04A patent/RU2188197C2/ru not_active IP Right Cessation
- 1997-10-03 ZA ZA9708864A patent/ZA978864B/xx unknown
- 1997-10-03 US US08/943,726 patent/US5916889A/en not_active Expired - Fee Related
-
1999
- 1999-03-18 US US09/271,565 patent/US6040302A/en not_active Expired - Fee Related
- 1999-03-18 US US09/271,785 patent/US6004961A/en not_active Expired - Fee Related
- 1999-03-18 US US09/271,564 patent/US6133268A/en not_active Expired - Fee Related
- 1999-03-30 NO NO991565A patent/NO991565L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0934312T3 (da) | 2003-07-21 |
| US5916889A (en) | 1999-06-29 |
| ATE234831T1 (de) | 2003-04-15 |
| PL332597A1 (en) | 1999-09-27 |
| CA2267835A1 (en) | 1998-04-16 |
| HUP0000090A2 (hu) | 2001-04-28 |
| HUP0000090A3 (en) | 2002-01-28 |
| DE69720021T2 (de) | 2004-02-05 |
| CN1088459C (zh) | 2002-07-31 |
| RU2188197C2 (ru) | 2002-08-27 |
| ZA978864B (en) | 1998-04-06 |
| NO991565L (no) | 1999-06-04 |
| US6004961A (en) | 1999-12-21 |
| NO991565D0 (no) | 1999-03-30 |
| PL188338B1 (pl) | 2005-01-31 |
| WO1998015548A1 (en) | 1998-04-16 |
| US6133268A (en) | 2000-10-17 |
| EP0934312B1 (en) | 2003-03-19 |
| AU740662B2 (en) | 2001-11-08 |
| JP2001502307A (ja) | 2001-02-20 |
| DE69720021D1 (de) | 2003-04-24 |
| CN1234799A (zh) | 1999-11-10 |
| BR9712196A (pt) | 1999-08-31 |
| EP0934312A1 (en) | 1999-08-11 |
| AU4377297A (en) | 1998-05-05 |
| KR20000048899A (ko) | 2000-07-25 |
| US6040302A (en) | 2000-03-21 |
| IL129123A (en) | 2004-07-25 |
| IL129123A0 (en) | 2000-02-17 |
| ES2194217T3 (es) | 2003-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic |