ZA978864B - 1,4-disubstituted piperazines. - Google Patents

1,4-disubstituted piperazines.

Info

Publication number: ZA978864B
Authority: ZA; South Africa
Prior art keywords: insulin; disubstituted piperazines; treatment; present; hyperalgesic
Prior art date: 1996-10-04

Application number

ZA9708864A

Other languages

English (en)

Inventor

Rolf Hohlweg

Peter Madsen

Tine Krogh Jorgensen

Knud Erik Andersen

Brett Watson

Zdenek Polivka

Otylie Konigova

Martina Kovandova

Alexandra Silhankova

Vladimir Valenta

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-04

Filing date

1997-10-03

Publication date

1998-04-06

1997-10-03 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1998-04-06 Publication of ZA978864B publication Critical patent/ZA978864B/xx

Links

-1 1,4-disubstituted piperazines Chemical class 0.000 title abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
208000007920 Neurogenic Inflammation Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
230000032683 aging Effects 0.000 abstract 1
230000000917 hyperalgesic effect Effects 0.000 abstract 1
230000004968 inflammatory condition Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
208000004296 neuralgia Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
230000001991 pathophysiological effect Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
210000001170 unmyelinated nerve fiber Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
- C07C2603/78—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing seven-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA9708864A 1996-10-04 1997-10-03 1,4-disubstituted piperazines. ZA978864B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK109096		1996-10-04

Publications (1)

Publication Number	Publication Date
ZA978864B true ZA978864B (en)	1998-04-06

Family

ID=8100883

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9708864A ZA978864B (en)	1996-10-04	1997-10-03	1,4-disubstituted piperazines.

Country Status (20)

Country	Link
US (4)	US5916889A (xx)
EP (1)	EP0934312B1 (xx)
JP (1)	JP2001502307A (xx)
KR (1)	KR20000048899A (xx)
CN (1)	CN1088459C (xx)
AT (1)	ATE234831T1 (xx)
AU (1)	AU740662B2 (xx)
BR (1)	BR9712196A (xx)
CA (1)	CA2267835A1 (xx)
CZ (1)	CZ114099A3 (xx)
DE (1)	DE69720021T2 (xx)
DK (1)	DK0934312T3 (xx)
ES (1)	ES2194217T3 (xx)
HU (1)	HUP0000090A3 (xx)
IL (1)	IL129123A (xx)
NO (1)	NO991565L (xx)
PL (1)	PL188338B1 (xx)
RU (1)	RU2188197C2 (xx)
WO (1)	WO1998015548A1 (xx)
ZA (1)	ZA978864B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ114199A3 (cs) *	1996-10-04	1999-09-15	Novo Nordisk A/S	N-Substituované azaheterocyklické sloučeniny
US6613905B1 (en) *	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US7045519B2 (en) *	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
KR100581199B1 (ko)	1998-06-19	2006-05-17	카이론 코포레이션	글리코겐 신타제 키나제 3의 억제제
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US20040038861A1 (en) *	2001-11-26	2004-02-26	Cooper Garth J. S.	Methods and compositions for normalizing lipid levels in mammalian tissues
TWI291467B (en)	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor
WO2006034473A2 (en) *	2004-09-23	2006-03-30	Reddy Us Therapeutics, Inc.	Novel pyrimidine compounds, process for their preparation and compositions containing them
FR2885616B1 (fr) *	2005-05-12	2007-06-22	Servier Lab	Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2885615B1 (fr) *	2005-05-12	2007-06-22	Servier Lab	Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2218442A1 (en)	2005-11-09	2010-08-18	CombinatoRx, Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
AU2008287285B2 (en) *	2007-04-13	2013-05-16	Southern Research Institute	Anti-angiogenic agents and methods of use
CN103086898B (zh) *	2012-07-11	2015-04-08	山东道可化学有限公司	二苯胺或其环上取代的衍生物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL102488C (xx) *	1957-07-18
GB1013901A (en) *	1962-01-26	1965-12-22	Kefalas As	Dihydroanthracene, dibenzocycloheptadiene and dibenzocycloheptatriene derivatives
FR88751E (xx) *	1963-07-09	1967-06-07
US3435073A (en) *	1966-04-19	1969-03-25	Colgate Palmolive Co	5-(n-benzyl-n-lower alkylaminoalkylene)-5h-dibenzo(a,d)cycloheptenes
GB1323659A (en) *	1971-04-10	1973-07-18	Yoshitomi Pharmaceutical	Piperazine derivatives methods for their production and pharmaceuticl compositions containing them
FR2186249A1 (en) *	1972-05-31	1974-01-11	Synthelabo	Phenyl piperazinoalkyl (dihydro)dibenzazepines - antidepressants having low toxicity
HU174126B (hu) *	1977-08-02	1979-11-28	Egyt Gyogyszervegyeszeti Gyar	Sposob poluchenija novykh proizvodnykh dibenzo-kvadratnaja skobka-d,g-kvadratnaja skobka zakryta-kvadratnaja skobka-1,3,6-kvadratnaja skobka zakryta-dioksazocina
ES8502099A1 (es) *	1983-08-02	1984-12-16	Espanola Farma Therapeut	Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina.
AU612437B2 (en) *	1987-12-14	1991-07-11	Kyowa Hakko Kogyo Co. Ltd.	Tricyclic compounds
NZ238629A (en) *	1990-06-22	1993-09-27	Schering Corp	Bis-benzo- or benzopyrido-cyclohepta (where z is c, o, s or n) piperidine, piperidylidene or piperazine compounds, medicaments and methods of preparation
EP0535232A4 (en) *	1990-06-22	1993-05-05	Taisho Pharmaceutical Co. Ltd	Naphthothiopyranone derivative
MY113463A (en) *	1994-01-04	2002-03-30	Novo Nordisk As	Novel heterocyclic compounds
UA54385C2 (uk) *	1995-04-07	2003-03-17	Ново Нордіск А/С	N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування
WO1997011071A1 (en) *	1995-09-19	1997-03-27	Novo Nordisk A/S	Novel heterocyclic compounds

1997
- 1997-10-02 DE DE69720021T patent/DE69720021T2/de not_active Expired - Fee Related
- 1997-10-02 AT AT97941884T patent/ATE234831T1/de not_active IP Right Cessation
- 1997-10-02 WO PCT/DK1997/000422 patent/WO1998015548A1/en not_active Ceased
- 1997-10-02 KR KR1019990702928A patent/KR20000048899A/ko not_active Ceased
- 1997-10-02 AU AU43772/97A patent/AU740662B2/en not_active Ceased
- 1997-10-02 EP EP97941884A patent/EP0934312B1/en not_active Expired - Lifetime
- 1997-10-02 CA CA002267835A patent/CA2267835A1/en not_active Abandoned
- 1997-10-02 JP JP10517093A patent/JP2001502307A/ja not_active Ceased
- 1997-10-02 ES ES97941884T patent/ES2194217T3/es not_active Expired - Lifetime
- 1997-10-02 IL IL12912397A patent/IL129123A/en not_active IP Right Cessation
- 1997-10-02 CZ CZ991140A patent/CZ114099A3/cs unknown
- 1997-10-02 RU RU99109024/04A patent/RU2188197C2/ru not_active IP Right Cessation
- 1997-10-02 BR BR9712196-7A patent/BR9712196A/pt not_active IP Right Cessation
- 1997-10-02 PL PL97332597A patent/PL188338B1/pl not_active IP Right Cessation
- 1997-10-02 CN CN97199184A patent/CN1088459C/zh not_active Expired - Fee Related
- 1997-10-02 DK DK97941884T patent/DK0934312T3/da active
- 1997-10-02 HU HU0000090A patent/HUP0000090A3/hu unknown
- 1997-10-03 US US08/943,726 patent/US5916889A/en not_active Expired - Fee Related
- 1997-10-03 ZA ZA9708864A patent/ZA978864B/xx unknown
1999
- 1999-03-18 US US09/271,564 patent/US6133268A/en not_active Expired - Fee Related
- 1999-03-18 US US09/271,565 patent/US6040302A/en not_active Expired - Fee Related
- 1999-03-18 US US09/271,785 patent/US6004961A/en not_active Expired - Fee Related
- 1999-03-30 NO NO991565A patent/NO991565L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1234799A (zh)	1999-11-10
RU2188197C2 (ru)	2002-08-27
US6040302A (en)	2000-03-21
ES2194217T3 (es)	2003-11-16
EP0934312B1 (en)	2003-03-19
US6004961A (en)	1999-12-21
NO991565D0 (no)	1999-03-30
HUP0000090A2 (hu)	2001-04-28
CZ114099A3 (cs)	1999-09-15
DE69720021T2 (de)	2004-02-05
DE69720021D1 (de)	2003-04-24
PL188338B1 (pl)	2005-01-31
WO1998015548A1 (en)	1998-04-16
DK0934312T3 (da)	2003-07-21
NO991565L (no)	1999-06-04
IL129123A (en)	2004-07-25
ATE234831T1 (de)	2003-04-15
JP2001502307A (ja)	2001-02-20
BR9712196A (pt)	1999-08-31
IL129123A0 (en)	2000-02-17
US5916889A (en)	1999-06-29
KR20000048899A (ko)	2000-07-25
EP0934312A1 (en)	1999-08-11
US6133268A (en)	2000-10-17
PL332597A1 (en)	1999-09-27
HUP0000090A3 (en)	2002-01-28
AU4377297A (en)	1998-05-05
AU740662B2 (en)	2001-11-08
CA2267835A1 (en)	1998-04-16
CN1088459C (zh)	2002-07-31

Publication	Publication Date	Title
ZA978864B (en)	1998-04-06	1,4-disubstituted piperazines.
ATE469161T1 (de)	2010-06-15	Pyrazolderivat, dieses enthaltende medizinische zusammensetzung, medizinische verwendung davon, und zwischenprodukt für dessen herstellung
MY132056A (en)	2007-09-28	Methods of inhibiting physiological conditions associated with an excess of neuropeptide y.
SE0001899D0 (sv)	2000-05-22	New compounds
HU9601842D0 (en)	1996-09-30	Novel heterocyclic compounds
IL171977A (en)	2010-12-30	Cyclic sulfonamide for inhibition of gamma-secretase, process for its preparation and a pharmaceutical composition comprising the same
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