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CY2341B1 - Bicyclic amino acids. - Google Patents

Bicyclic amino acids.

Info

Publication number
CY2341B1
CY2341B1 CY0300028A CY0300028A CY2341B1 CY 2341 B1 CY2341 B1 CY 2341B1 CY 0300028 A CY0300028 A CY 0300028A CY 0300028 A CY0300028 A CY 0300028A CY 2341 B1 CY2341 B1 CY 2341B1
Authority
CY
Cyprus
Prior art keywords
amino acids
bicyclic amino
bicyclic
acids
amino
Prior art date
Application number
CY0300028A
Inventor
Beate Diefenbach
Simon Goodman
Joachim Marz
Peter Raddatz
Friedrich Rippmann
Matthias Wiesner
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CY2341B1 publication Critical patent/CY2341B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CY0300028A 1997-02-13 2003-03-17 Bicyclic amino acids. CY2341B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19705450A DE19705450A1 (en) 1997-02-13 1997-02-13 Bicyclic aromatic amino acids

Publications (1)

Publication Number Publication Date
CY2341B1 true CY2341B1 (en) 2004-02-06

Family

ID=7820093

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300028A CY2341B1 (en) 1997-02-13 2003-03-17 Bicyclic amino acids.

Country Status (25)

Country Link
EP (1) EP0964856B1 (en)
JP (1) JP4327257B2 (en)
KR (1) KR20000071030A (en)
CN (1) CN1085205C (en)
AR (1) AR010894A1 (en)
AT (1) ATE225776T1 (en)
AU (1) AU735313B2 (en)
BR (1) BR9807345A (en)
CA (1) CA2280727C (en)
CY (1) CY2341B1 (en)
CZ (1) CZ297366B6 (en)
DE (2) DE19705450A1 (en)
DK (1) DK0964856T3 (en)
ES (1) ES2183332T3 (en)
HU (1) HUP0001138A3 (en)
ID (1) ID22533A (en)
NO (1) NO313289B1 (en)
PL (1) PL335101A1 (en)
PT (1) PT964856E (en)
RU (1) RU2187506C2 (en)
SI (1) SI0964856T1 (en)
SK (1) SK284646B6 (en)
TR (1) TR199901962T2 (en)
WO (1) WO1998035949A1 (en)
ZA (1) ZA981178B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040063790A1 (en) * 1996-05-31 2004-04-01 The Scripps Research Institute Methods for inhibition of angiogenesis
CA2327673C (en) 1998-04-09 2009-08-25 Meiji Seika Kaisha, Ltd. Aminopiperidine derivatives as integrin .alpha.v.beta.3 antagonists
JP3936844B2 (en) 1999-04-13 2007-06-27 ビーエーエスエフ アクチェンゲゼルシャフト Integrin receptor ligand
WO2001010844A1 (en) 1999-08-05 2001-02-15 Meiji Seika Kaisha, Ltd. φ-AMINO-α-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN αvβ3 ANTAGONISM
EP1244616A1 (en) * 1999-12-24 2002-10-02 SmithKline Beecham plc (hetero)bicyclylmethanesulfonylamino-substituted hydroxamic acid derivatives
US6617461B2 (en) * 2000-01-25 2003-09-09 Kaneka Corporation Process for preparation of optically active N-substituted azetidine-2-carboxylic acids
DK1381382T3 (en) * 2000-11-01 2009-02-02 Merck Patent Gmbh Methods and Preparations for the Treatment of Eye Diseases
CN100571772C (en) * 2000-11-01 2009-12-23 默克专利有限公司 Use of antagonists of the integrin receptors α v β 3 and/or α v β 5 for the production of medicaments for the treatment of eye diseases
US7025987B2 (en) 2001-05-30 2006-04-11 The Scripps Research Institute Delivery system for nucleic acids
ES2243744T3 (en) * 2001-08-01 2005-12-01 Merck Patent Gmbh INTEGRIN INHIBITORS FOR THE TREATMENT OF EYE DISEASES.
EP1474162A1 (en) * 2002-02-14 2004-11-10 MERCK PATENT GmbH Methods and compositions for the treatment of eye diseases
FR2847254B1 (en) * 2002-11-19 2005-01-28 Aventis Pharma Sa NOVEL VITRONECTIN RECEPTOR ANTAGONIST DERIVATIVES, PROCESS FOR PREPARING THEM, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS REFLECTING THEM
DE10305784A1 (en) * 2003-02-12 2004-08-26 Merck Patent Gmbh 3-Oxo-3,4-dihydro-2H-benz-(1,4)-oxazin-6-yl)-propionic acid derivative preparation, for use as integrin inhibitors with e.g. antitumor action, by multi-stage process giving diastereomerically pure product
DE10337863A1 (en) 2003-08-18 2005-03-17 Merck Patent Gmbh Use of chromene-4-one derivatives
EP2484365B1 (en) * 2004-06-04 2013-10-02 The Scripps Research Institute Compositions and method for treatment of neovascular diseases
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
SI2380881T1 (en) * 2008-12-26 2017-05-31 Sumitomo Dainippon Pharma Co., Ltd. Novel bicyclic heterocyclic compound
WO2011024987A1 (en) * 2009-08-31 2011-03-03 塩野義製薬株式会社 Aromatic fused heterocyclic derivative and pharmaceutical composition containing same
JP6080226B2 (en) 2012-03-06 2017-02-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Benzodioxane for inhibiting leukotriene production in combination with other active substances
WO2014014874A1 (en) 2012-07-17 2014-01-23 Boehringer Ingelheim International Gmbh Pyrazole derivatives which inhibit leukotriene production
US9573957B2 (en) 2013-07-15 2017-02-21 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
JP6353899B2 (en) 2013-07-15 2018-07-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Inhibitors of leukotriene production
MX2016015467A (en) 2014-05-30 2017-03-23 Pfizer Carbonitrile derivatives as selective androgen receptor modulators.
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators
JP2024542963A (en) 2021-11-01 2024-11-19 アルカヘスト,インコーポレイテッド Benzodioxane Modulators of Leukotriene A4 Hydrolase (LTA4H) for the Prevention and Treatment of Age-Related Diseases - Patent application

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3151690A1 (en) * 1981-12-29 1983-07-07 Hoechst Ag, 6230 Frankfurt Novel derivatives of bicyclic amino acids, process for their preparation, compositions containing them and their use, and also novel bicyclic amino acids as intermediates and process for their preparation
FR2674854B1 (en) * 1991-04-04 1995-03-03 Bouchara NEW QUINOLONES THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS THEREOF.
AU675689B2 (en) * 1992-12-01 1997-02-13 Merck & Co., Inc. Fibrinogen receptor antagonists
JPH10501222A (en) * 1994-05-27 1998-02-03 メルク エンド カンパニー インコーポレーテッド Compounds for inhibiting osteoclast-mediated bone resorption
DE19548709A1 (en) * 1995-12-23 1997-07-03 Merck Patent Gmbh Tyrosine derivatives
SK176898A3 (en) * 1996-06-28 1999-05-07 Merck Patent Gmbh Phenylalamine derivatives as integrin inhibitors
DE19654483A1 (en) * 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanine derivatives

Also Published As

Publication number Publication date
DE59805895D1 (en) 2002-11-14
PL335101A1 (en) 2000-04-10
HUP0001138A3 (en) 2002-10-28
SI0964856T1 (en) 2003-04-30
SK284646B6 (en) 2005-08-04
ES2183332T3 (en) 2003-03-16
EP0964856B1 (en) 2002-10-09
EP0964856A1 (en) 1999-12-22
CZ287599A3 (en) 1999-11-17
NO313289B1 (en) 2002-09-09
JP2001511789A (en) 2001-08-14
CN1252064A (en) 2000-05-03
BR9807345A (en) 2000-03-21
ID22533A (en) 1999-10-28
ATE225776T1 (en) 2002-10-15
AU6620698A (en) 1998-09-08
SK107199A3 (en) 2000-05-16
WO1998035949A1 (en) 1998-08-20
ZA981178B (en) 1999-05-21
CZ297366B6 (en) 2006-11-15
DK0964856T3 (en) 2003-02-10
TR199901962T2 (en) 1999-12-21
RU2187506C2 (en) 2002-08-20
CA2280727A1 (en) 1998-08-20
CA2280727C (en) 2008-05-06
NO993901D0 (en) 1999-08-12
JP4327257B2 (en) 2009-09-09
HUP0001138A2 (en) 2001-05-28
DE19705450A1 (en) 1998-08-20
CN1085205C (en) 2002-05-22
NO993901L (en) 1999-10-12
AU735313B2 (en) 2001-07-05
AR010894A1 (en) 2000-07-12
PT964856E (en) 2003-02-28
KR20000071030A (en) 2000-11-25

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