[go: up one dir, main page]

CY1119368T1 - Νεα παραγωγα αδενινης - Google Patents

Νεα παραγωγα αδενινης

Info

Publication number
CY1119368T1
CY1119368T1 CY20171100953T CY171100953T CY1119368T1 CY 1119368 T1 CY1119368 T1 CY 1119368T1 CY 20171100953 T CY20171100953 T CY 20171100953T CY 171100953 T CY171100953 T CY 171100953T CY 1119368 T1 CY1119368 T1 CY 1119368T1
Authority
CY
Cyprus
Prior art keywords
treatment
adenin
producers
new
het
Prior art date
Application number
CY20171100953T
Other languages
English (en)
Inventor
Helene Bazin-Lee
Diane Mary Coe
Linos Lazarides
Charlotte Jane Mitchell
Stephen Allan Smith
Naimisha Trivedi
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CY1119368T1 publication Critical patent/CY1119368T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Ενώσεις του τύπου (I) όπου R1 είναι C1-6αλκυλάμινο ή C1-6αλκόξυ· R2 είναι ομάδα που έχει τη σύνταξη (II): n είναι ακέραιος που έχει τιμή 1 έως 6· Het είναι 6-μελής κορεσμένος ετερόκυκλος που περιέχει ένα άτομο αζώτου όπου Het συνδέεται προς την -(CH2)n- χαρακτηριστική ομάδα σε οποιοδήποτε άτομο άνθρακα του ετερόκυκλου· R3 είναι υδρογόνο, C1-8αλκύλ ή C3-7κυκλοαλκυλC0-6αλκύλ· και άλατα αυτών είναι διεγέρτες ανθρώπινης ιντερφερόνης. Ενώσεις οι οποίες διεγείρουν ανθρώπινη ιντερφερόνη μπορεί να είναι χρήσιμες στη θεραπεία διαφόρων διαταραχών, για παράδειγμα στη θεραπεία αλλεργικών ασθενειών και άλλων φλεγμονωδών καταστάσεων, για παράδειγμα αλλεργικής ρινίτιδας και άσθματος, τη θεραπεία μολυσματωδών ασθενειών και καρκίνου και μπορεί επίσης να είναι χρήσιμες ως ανοσοενισχυτικά εμβολίου.
CY20171100953T 2008-08-11 2017-09-08 Νεα παραγωγα αδενινης CY1119368T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8777308P 2008-08-11 2008-08-11
PCT/EP2009/060267 WO2010018134A1 (en) 2008-08-11 2009-08-07 Novel adenine derivatives

Publications (1)

Publication Number Publication Date
CY1119368T1 true CY1119368T1 (el) 2018-02-14

Family

ID=41152355

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100953T CY1119368T1 (el) 2008-08-11 2017-09-08 Νεα παραγωγα αδενινης

Country Status (23)

Country Link
US (1) US8563717B2 (el)
EP (2) EP3246030A1 (el)
JP (2) JP5785078B2 (el)
KR (2) KR101616396B1 (el)
CN (2) CN102176911B (el)
AU (1) AU2009281198B2 (el)
BR (1) BRPI0917013A2 (el)
CA (1) CA2733750C (el)
CY (1) CY1119368T1 (el)
DK (1) DK2320905T3 (el)
EA (1) EA019204B1 (el)
ES (1) ES2640535T3 (el)
HR (1) HRP20171398T1 (el)
HU (1) HUE033645T2 (el)
IL (1) IL210855A (el)
LT (1) LT2320905T (el)
MX (1) MX2011001663A (el)
PL (1) PL2320905T3 (el)
PT (1) PT2320905T (el)
SG (1) SG193149A1 (el)
SI (1) SI2320905T1 (el)
WO (1) WO2010018134A1 (el)
ZA (1) ZA201101104B (el)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2387388T3 (es) * 2002-09-27 2012-09-21 Dainippon Sumitomo Pharma Co., Ltd. Compuesto de adenina y uso del mismo
MXPA06011080A (es) 2004-03-26 2007-04-16 Astrazeneca Ab Compuesto de 8-oxoadenina 9-sustituido.
WO2008004948A1 (en) * 2006-07-05 2008-01-10 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of tlr7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
ATE490249T1 (de) * 2007-02-19 2010-12-15 Glaxosmithkline Llc Purinderivate als immunmodulatoren
US8067413B2 (en) * 2007-03-19 2011-11-29 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators
WO2008114006A1 (en) * 2007-03-19 2008-09-25 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators
WO2008114819A1 (ja) * 2007-03-20 2008-09-25 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
AR065784A1 (es) * 2007-03-20 2009-07-01 Dainippon Sumitomo Pharma Co Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
ES2541434T3 (es) 2007-06-29 2015-07-20 Gilead Sciences, Inc. Derivados de purina y su uso como moduladores del receptor de tipo Toll 7
EP2138494A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
US8802684B2 (en) * 2008-08-11 2014-08-12 Glaxosmithkline Llc Adenine derivatives
US8575181B2 (en) 2008-08-11 2013-11-05 Glaxosmithkline Llc Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
CA2733750C (en) * 2008-08-11 2016-10-11 Glaxosmithkline Llc Novel adenine derivatives
US20100209540A1 (en) * 2008-11-05 2010-08-19 Pharmacaribe Inhalation formulation for treating and prophylactic use in bacteria, mycobacterial and fungal respiratory infections
TW201639852A (zh) 2008-12-09 2016-11-16 吉李德科學股份有限公司 用於製備可用作類鐸受體調節劑之化合物的中間體化合物
NO2491035T3 (el) 2009-10-22 2018-01-27
EP2534148A1 (en) 2010-02-10 2012-12-19 GlaxoSmithKline LLC Purine derivatives and their pharmaceutical uses
WO2013014052A1 (en) * 2011-07-22 2013-01-31 Glaxosmithkline Llc Composition
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
MY175676A (en) 2012-08-24 2020-07-06 Glaxosmithkline Llc Pyrazolopyrimidine compounds
EP2922547B1 (en) 2012-11-20 2017-03-08 Glaxosmithkline LLC Novel compounds
HRP20171150T1 (hr) 2012-11-20 2017-10-06 Glaxosmithkline Llc Novi spojevi
EP2922550B1 (en) * 2012-11-20 2017-04-19 Glaxosmithkline LLC Novel compounds
NZ728072A (en) 2014-07-11 2018-06-29 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
CA2960436C (en) 2014-09-16 2021-01-05 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
BR112017009648A2 (pt) * 2014-11-13 2017-12-19 Glaxosmithkline Biologicals Sa composto, métodos para tratamento de doenças alérgicas ou outras condições inflamatórias ou prevenção de doença, de rinite alérgica ou asma, composição, e, uso de um composto.
WO2016142880A1 (en) 2015-03-10 2016-09-15 Glaxosmithkline Biologicals Sa Compositions and uses
WO2017021912A1 (en) 2015-08-06 2017-02-09 Glaxosmithkline Intellectual Property Development Limited Combined tlrs modulators with anti ox40 antibodies
CN109476696B (zh) * 2016-06-02 2022-06-10 细胞基因公司 动物及人抗锥虫和抗利什曼原虫剂
JP6744622B2 (ja) * 2016-06-16 2020-08-19 学校法人上智学院 ピペリジン化合物の製造方法
AR110963A1 (es) * 2017-02-07 2019-05-22 Dae Woong Pharma Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende
JP7169968B2 (ja) 2017-03-29 2022-11-11 住友ファーマ株式会社 ワクチンアジュバント製剤
US10494370B2 (en) 2017-08-16 2019-12-03 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
US12226480B2 (en) 2017-12-21 2025-02-18 Sumitomo Pharma Co., Ltd. Combination drug including TLR7 agonist
US20210371440A1 (en) 2018-04-13 2021-12-02 Glaxosmithkline Biologicals Sa Tlr7 and / or tlr8 agonists
KR20210034614A (ko) 2018-07-23 2021-03-30 국립감염증연구소장이 대표하는 일본국 인플루엔자 백신을 포함하는 조성물
EP4232094A1 (en) 2020-10-21 2023-08-30 Univerza V Ljubljani Conjugated tlr7 and nod2 agonists
AU2022272111B2 (en) * 2021-05-13 2024-10-17 Daewoong Pharmaceutical Co., Ltd. Pharmaceutical composition for preventing or treating fibrosis
AU2022274469B2 (en) * 2021-05-13 2025-06-05 Daewoong Pharmaceutical Co., Ltd. Pharmaceutical composition for prevention or treatment of fibrosis
CN118401508A (zh) * 2021-12-17 2024-07-26 株式会社大熊制药 (2R,3S)-2-(3-(4,5-二氯-1H-苯并[d]咪唑-1-基)丙基)哌啶-3-醇的新酸加成盐及晶形
KR102798169B1 (ko) * 2021-12-17 2025-04-21 주식회사 대웅제약 (2R, 3S)-2-(벤조[d]이미다졸일프로필)피페리딘-3-올 유도체의 제조 방법
WO2025040743A1 (en) 2023-08-22 2025-02-27 Univerza V Ljubljani Conjugated tlr7 and rig-i agonists
WO2025093657A1 (en) 2023-10-31 2025-05-08 Univerza V Ljubljani Conjugated tlr7 and tlr4 agonists

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0689424B1 (en) 1993-03-17 1998-10-14 Minnesota Mining And Manufacturing Company Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
TW574214B (en) 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
TW572758B (en) 1997-12-22 2004-01-21 Sumitomo Pharma Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
CZ27399A3 (cs) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
CA2310896A1 (en) 1999-07-02 2001-01-02 Japan Tobacco Inc. Hcv polymerase suitable for crystal structure analysis and method for using the enzyme
WO2001047883A1 (fr) 1999-12-27 2001-07-05 Japan Tobacco Inc. Composes a cycles accoles et leur utilisation comme medicaments
WO2001049688A1 (en) 2000-01-07 2001-07-12 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US6310224B1 (en) 2001-01-19 2001-10-30 Arco Chemical Technology, L.P. Epoxidation catalyst and process
SI1355916T1 (sl) 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
CN1533390A (zh) 2001-03-19 2004-09-29 СҰҩƷ��ҵ��ʽ���� 包含三氮杂螺[5.5]十一烷衍生物作为活性成分的药物组合物
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
CA2448737C (en) 2001-07-20 2010-06-01 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
CA2481502A1 (en) 2002-04-04 2003-10-16 Achillion Pharmaceuticals, Inc. Hcv antiviral and cytotoxicity drug screening assay
DOP2003000641A (es) 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
WO2004037818A1 (en) 2002-10-24 2004-05-06 Glaxo Group Limited 1-acyl-pyrrolidine derivatives for the treatment of viral infections
CN1744899A (zh) 2002-12-13 2006-03-08 史密丝克莱恩比彻姆公司 作为ccr5拮抗剂的哌啶衍生物
ES2309400T3 (es) 2002-12-13 2008-12-16 Smithkline Beecham Corporation Compuestos de pirrolidina y azetidina como antagonistas de ccr5.
JP2006514950A (ja) 2002-12-13 2006-05-18 スミスクライン ビーチャム コーポレーション Ｃｃｒ５拮抗薬としてのシクロプロピル化合物
US7531661B2 (en) 2002-12-13 2009-05-12 Smithkline Beecham Corporation Indane compounds as CCR5 antagonists
ATE405269T1 (de) 2002-12-13 2008-09-15 Smithkline Beecham Corp Cyclohexylverbindungen als ccr5-antagonisten
AU2003300911A1 (en) 2002-12-13 2004-07-09 Smithkline Beecham Corporation Heterocyclic compounds as ccr5 antagonists
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
AU2004253543B2 (en) 2003-07-01 2009-02-19 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
WO2005014543A1 (ja) 2003-08-06 2005-02-17 Japan Tobacco Inc. 縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用
US20070161582A1 (en) 2003-08-08 2007-07-12 Dusan Mijikovic Pharmaceutical compositions and methods for metabolic modulation
CA2537450C (en) 2003-09-05 2012-04-17 Anadys Pharmaceuticals, Inc. Administration of tlr7 ligands and prodrugs thereof for treatment of infection by hepatitis c virus
JP4641526B2 (ja) 2003-11-03 2011-03-02 グラクソ グループ リミテッド 流体分配デバイス
CN103319464A (zh) 2004-02-20 2013-09-25 贝林格尔.英格海姆国际有限公司 病毒聚合酶抑制剂
CA2564175A1 (en) 2004-04-28 2005-11-10 Arrow Therapeutics Limited Chemical compounds
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
HRP20110458T1 (hr) 2004-08-18 2011-07-31 Pfizer Inc. Inhibitori rna-ovisne rna-polimeraze iz virusa hepatitisa c, te pripravci i liječenje u kojem se koriste
WO2006026394A2 (en) 2004-08-27 2006-03-09 3M Innovative Properties Company Method of eliciting an immune response against hiv
GB0423673D0 (en) 2004-10-25 2004-11-24 Glaxo Group Ltd Compounds
CN101203519A (zh) 2005-05-04 2008-06-18 辉瑞有限公司 用于治疗癌症和病毒感染如丙型肝炎的用作Toll样受体调节剂的2－酰氨基－6－氨基－8－氧代嘌呤衍生物
UA92746C2 (en) 2005-05-09 2010-12-10 Акилайон Фармасьютикалз, Инк. Thiazole compounds and methods of use
AU2006287157A1 (en) 2005-09-02 2007-03-08 Pfizer Inc. Hydroxy substituted 1H-imidazopyridines and methods
TW200745114A (en) * 2005-09-22 2007-12-16 Astrazeneca Ab Novel compounds
WO2007034882A1 (ja) 2005-09-22 2007-03-29 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
EP1939198A4 (en) 2005-09-22 2012-02-15 Dainippon Sumitomo Pharma Co NEW ADENINE CONNECTION
CN1947717B (zh) 2005-10-14 2012-09-26 卓敏 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用
ES2374455T3 (es) 2006-02-17 2012-02-16 Pfizer Limited Derivados de 3-deazapurinza como moduladores de tlr7.
GB0610666D0 (en) 2006-05-30 2006-07-05 Glaxo Group Ltd Fluid dispenser
EP2029597A4 (en) * 2006-05-31 2011-11-23 Univ California purine analogs
ATE490249T1 (de) 2007-02-19 2010-12-15 Glaxosmithkline Llc Purinderivate als immunmodulatoren
US8067413B2 (en) * 2007-03-19 2011-11-29 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators
WO2008114819A1 (ja) * 2007-03-20 2008-09-25 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
WO2010018132A1 (en) 2008-08-11 2010-02-18 Smithkline Beecham Corporation Compounds
US8575181B2 (en) 2008-08-11 2013-11-05 Glaxosmithkline Llc Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
CA2733750C (en) * 2008-08-11 2016-10-11 Glaxosmithkline Llc Novel adenine derivatives
AU2009281195A1 (en) 2008-08-11 2010-02-18 Glaxosmithkline Llc Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
CN102469790B (zh) * 2009-08-07 2014-12-03 葛兰素史密丝克莱恩生物有限公司 脂质化氧代腺嘌呤衍生物
EP2534148A1 (en) * 2010-02-10 2012-12-19 GlaxoSmithKline LLC Purine derivatives and their pharmaceutical uses

Also Published As

Publication number Publication date
EP2320905B1 (en) 2017-06-28
BRPI0917013A2 (pt) 2016-02-16
LT2320905T (lt) 2017-09-11
PT2320905T (pt) 2017-09-19
DK2320905T3 (en) 2017-09-18
HUE033645T2 (en) 2017-12-28
CN104530048B (zh) 2016-09-14
US20110144136A1 (en) 2011-06-16
KR20160003893A (ko) 2016-01-11
AU2009281198A1 (en) 2010-02-18
JP2011530564A (ja) 2011-12-22
WO2010018134A1 (en) 2010-02-18
JP5785078B2 (ja) 2015-09-24
HRP20171398T1 (hr) 2017-11-03
ES2640535T3 (es) 2017-11-03
CN102176911A (zh) 2011-09-07
CN102176911B (zh) 2014-12-10
SI2320905T1 (sl) 2017-10-30
KR20110045055A (ko) 2011-05-03
CN104530048A (zh) 2015-04-22
CA2733750A1 (en) 2010-02-18
EP2320905A1 (en) 2011-05-18
MX2011001663A (es) 2011-03-24
AU2009281198B2 (en) 2014-09-25
IL210855A0 (en) 2011-04-28
EP3246030A1 (en) 2017-11-22
IL210855A (en) 2015-03-31
ZA201101104B (en) 2012-07-25
EA019204B1 (ru) 2014-01-30
EA201100115A1 (ru) 2011-10-31
KR101616396B1 (ko) 2016-04-28
JP2016006072A (ja) 2016-01-14
CA2733750C (en) 2016-10-11
PL2320905T3 (pl) 2018-04-30
US8563717B2 (en) 2013-10-22
KR101649881B1 (ko) 2016-08-30
SG193149A1 (en) 2013-09-30

Similar Documents

Publication Publication Date Title
CY1119368T1 (el) Νεα παραγωγα αδενινης
CY1111281T1 (el) Παραγωγα πουρινης ως ανοσοτροποποιητες
CY1119992T1 (el) Παραγωγα πουρινης για χρηση στη θεραπευτικη αγωγη αλλεργικων, φλεγμονωδων και λοιμωδων ασθενειων
CY1107008T1 (el) Παραγωγο βενζιμιδαζολης και χρηση ως ανταγωνιστου υποδοχεα aii
CY1113736T1 (el) Ετεροαρυλ-ουριες και η χρηση τους ως ενεργοποιητες γλυκοκινασης
CY1111069T1 (el) Παραγωγα διυδροπυραζολοπυριμιδινονης
CY1109821T1 (el) Ενωσεις πιπεραζινης με ζιζανιοκτονα δραση
CY1107677T1 (el) Παραγωγα της 1-[indol-3-yl)carbonyl]piperazine
MX2012015023A (es) Derivado novedoso de nicotinamida o sal del mismo.
CY1108313T1 (el) Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6
CY1105899T1 (el) Πυριδινοϋλοπιπepιδινες ως 5-ht1f αγωνιστες
DE60311821D1 (de) Dibenzylaminverbindung und deren medizinische verwendung
DE60103133D1 (de) Imidazol-2-carbonsäureamid derivate als raf kinase inhibitoren
DE60211343D1 (de) Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente
CY1110392T1 (el) Υποκατεστημενα παραγωγα μορφολινης και θειομορφολινης
CY1111911T1 (el) Ενωσεις πυριδο (2,3-d) πυριμιδινονης και χρηση αυτων ως αναστολεων ρι3
AR035111A1 (es) Procedimiento para preparar un compuesto de pirimidinona
EA201070891A1 (ru) Замещенные гетероариламидные производные диазепинопиримидона
CY1123864T1 (el) Νεα παραγωγα αμινο-ιμιδαζοπυριδινης σαν αναστολεις κινασης janus και φαρμακευτικες χρησεις
HUP0004477A2 (hu) Herbicid hatású 3-(1,2-benzizotiazol- vagy-izoxazol-5-il)-csoporttal helyettesített pirimidinszármazékok, intermedierjeik, előállításuk és alkalmazásuk
MY136628A (en) Substituted benzoyl derivatives uses as herbicides
DK1572699T3 (da) Krystallinske cefdinirsalte
EA201070010A1 (ru) Производные 7-алкинил-1,8-нафтиридонов, их получение и их применение в терапии
EA201170844A1 (ru) Ингибиторы цистеинпротеазы
PE20070212A1 (es) Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen