CY1119298T1 - Διαδικασια για παραγωγη μεγαλης κλιμακας του 1-(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-1 νdole dimesylate mono-enyδρου - Google Patents
Διαδικασια για παραγωγη μεγαλης κλιμακας του 1-(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-1 νdole dimesylate mono-enyδρουInfo
- Publication number
- CY1119298T1 CY1119298T1 CY20171100904T CY171100904T CY1119298T1 CY 1119298 T1 CY1119298 T1 CY 1119298T1 CY 20171100904 T CY20171100904 T CY 20171100904T CY 171100904 T CY171100904 T CY 171100904T CY 1119298 T1 CY1119298 T1 CY 1119298T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methyl
- bromophenyl
- piperazinyl
- sulfonyl
- methoxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 2-BROMOPHENYL Chemical class 0.000 title 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- XKDCUJBWVGDNSH-UHFFFAOYSA-N 1-(2-bromophenyl)sulfonyl-5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]indole;methanesulfonic acid;hydrate Chemical compound O.CS(O)(=O)=O.CS(O)(=O)=O.C12=CC(OC)=CC=C2N(S(=O)(=O)C=2C(=CC=CC=2)Br)C=C1CN1CCN(C)CC1 XKDCUJBWVGDNSH-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000003751 serotonin 6 antagonist Substances 0.000 abstract 1
- 238000002636 symptomatic treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Μία διαδικασία για την υιοθέτηση κατασκευής μεγάλης κλίμακας του 1[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate μονό-ένυδρου, που είναι ένας επιλεκτικός ανταγωνιστής υποδοχέα 5-ΗΤ6 που προορίζεται για την συμπτωματική θεραπεία της ασθένειας Alzheimer και άλλων διαταραχών της μνήμης και της νόησης όπως υπέρ-κινητικότητα έλλειψης προσοχής, ασθένεια Parkinson και Σχιζοφρένεια.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN5537CH2013 IN2013CH05537A (el) | 2013-12-02 | 2014-02-20 | |
| PCT/IN2014/000109 WO2015083179A1 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119298T1 true CY1119298T1 (el) | 2018-02-14 |
Family
ID=54199404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100904T CY1119298T1 (el) | 2013-12-02 | 2017-08-28 | Διαδικασια για παραγωγη μεγαλης κλιμακας του 1-(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-1 νdole dimesylate mono-enyδρου |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9540321B2 (el) |
| EP (1) | EP3077375B1 (el) |
| JP (1) | JP6151453B2 (el) |
| KR (1) | KR101808792B1 (el) |
| CN (1) | CN105814020B (el) |
| AP (1) | AP2016009224A0 (el) |
| AU (1) | AU2014358682B2 (el) |
| BR (1) | BR112016010788B1 (el) |
| CA (1) | CA2929309C (el) |
| CY (1) | CY1119298T1 (el) |
| DK (1) | DK3077375T3 (el) |
| EA (1) | EA028038B1 (el) |
| ES (1) | ES2638856T3 (el) |
| HK (1) | HK1226396B (el) |
| HR (1) | HRP20171245T1 (el) |
| HU (1) | HUE036008T2 (el) |
| IL (1) | IL245619B (el) |
| IN (1) | IN2013CH05537A (el) |
| LT (1) | LT3077375T (el) |
| ME (1) | ME02843B (el) |
| MX (1) | MX364930B (el) |
| NZ (1) | NZ719671A (el) |
| PL (1) | PL3077375T3 (el) |
| PT (1) | PT3077375T (el) |
| RS (1) | RS56323B1 (el) |
| SI (1) | SI3077375T1 (el) |
| SM (1) | SMT201700408T1 (el) |
| WO (1) | WO2015083179A1 (el) |
| ZA (1) | ZA201602954B (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3484467T3 (pl) | 2016-05-18 | 2020-08-24 | Suven Life Sciences Limited | Skojarzenie czystych antagonistów receptora 5-ht6 z inhibitorami acetylocholinesterazy |
| MX378799B (es) | 2016-05-18 | 2025-03-11 | Suven Life Sciences Ltd | Combinación de antagonistas del receptor 5-ht6 puro con un antagonista del receptor nmda. |
| JP6629464B2 (ja) * | 2016-05-18 | 2020-01-15 | スヴェン・ライフ・サイエンシズ・リミテッド | 純粋な５−ｈｔ６受容体アンタゴニスト、アセチルコリンエステラーゼ阻害剤及びｎｍｄａ受容体アンタゴニストの３種類の組合せ |
| US20210346374A1 (en) * | 2016-10-03 | 2021-11-11 | Suven Life Sciences Limited | Pharmaceutical compositions of 5-ht6 receptor antagonist |
| KR102083135B1 (ko) * | 2016-10-03 | 2020-02-28 | 수벤 라이프 사이언시스 리미티드 | 5-ht6 길항제의 약제학적 조성물 |
| CN110799189A (zh) * | 2017-07-03 | 2020-02-14 | 苏文生命科学有限公司 | 纯5-ht6受体拮抗剂的新用途 |
| JP7556031B2 (ja) | 2019-12-02 | 2024-09-25 | スヴェン・ライフ・サイエンシーズ・リミテッド | 認知症患者の行動心理学的症状の治療 |
| MD4069231T2 (ro) | 2019-12-02 | 2025-10-31 | Suven Life Sciences Ltd | Combinații de masupirdină cu donepezil sau memantină pentru tratarea simptomelor comportamentale și psihologice la pacienți cu demență |
| CN111362859B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| CN111362858B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| CN111233737B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| WO2022078927A1 (en) * | 2020-10-13 | 2022-04-21 | Boehringer Ingelheim International Gmbh | Process of reworking |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2749846B1 (fr) * | 1996-06-17 | 1998-09-11 | Pf Medicament | Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique |
| CN101544592B (zh) | 2002-11-28 | 2013-08-21 | 苏文生命科学有限公司 | N-芳基磺酰-3-取代吲哚制备的替代方法 |
| WO2004055026A1 (en) * | 2002-12-18 | 2004-07-01 | Suven Life Sciences Limited | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
| BRPI0713653A2 (pt) * | 2006-06-12 | 2012-10-23 | Novartis Ag | processo para a preparação de sais de n-hidróxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil ]fenil]-2e-2propenamida |
-
2014
- 2014-02-20 WO PCT/IN2014/000109 patent/WO2015083179A1/en not_active Ceased
- 2014-02-20 JP JP2016535680A patent/JP6151453B2/ja active Active
- 2014-02-20 SM SM20170408T patent/SMT201700408T1/it unknown
- 2014-02-20 HU HUE14725245A patent/HUE036008T2/hu unknown
- 2014-02-20 SI SI201430348T patent/SI3077375T1/sl unknown
- 2014-02-20 CA CA2929309A patent/CA2929309C/en active Active
- 2014-02-20 US US15/100,489 patent/US9540321B2/en active Active
- 2014-02-20 IN IN5537CH2013 patent/IN2013CH05537A/en unknown
- 2014-02-20 NZ NZ719671A patent/NZ719671A/en unknown
- 2014-02-20 PL PL14725245T patent/PL3077375T3/pl unknown
- 2014-02-20 EA EA201691161A patent/EA028038B1/ru unknown
- 2014-02-20 MX MX2016006629A patent/MX364930B/es active IP Right Grant
- 2014-02-20 KR KR1020167013965A patent/KR101808792B1/ko active Active
- 2014-02-20 AU AU2014358682A patent/AU2014358682B2/en active Active
- 2014-02-20 RS RS20170853A patent/RS56323B1/sr unknown
- 2014-02-20 ME MEP-2017-193A patent/ME02843B/me unknown
- 2014-02-20 HK HK16114655.9A patent/HK1226396B/zh unknown
- 2014-02-20 PT PT147252456T patent/PT3077375T/pt unknown
- 2014-02-20 LT LTEP14725245.6T patent/LT3077375T/lt unknown
- 2014-02-20 BR BR112016010788-8A patent/BR112016010788B1/pt active IP Right Grant
- 2014-02-20 DK DK14725245.6T patent/DK3077375T3/en active
- 2014-02-20 AP AP2016009224A patent/AP2016009224A0/en unknown
- 2014-02-20 HR HRP20171245TT patent/HRP20171245T1/hr unknown
- 2014-02-20 CN CN201480065601.9A patent/CN105814020B/zh active Active
- 2014-02-20 ES ES14725245.6T patent/ES2638856T3/es active Active
- 2014-02-20 EP EP14725245.6A patent/EP3077375B1/en active Active
-
2016
- 2016-05-03 ZA ZA2016/02954A patent/ZA201602954B/en unknown
- 2016-05-11 IL IL245619A patent/IL245619B/en active IP Right Grant
-
2017
- 2017-08-28 CY CY20171100904T patent/CY1119298T1/el unknown
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