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CY1118107T1 - Παραγωγα ετεροαρυλιου ως διαμορφωτες αλφα7 nachr - Google Patents

Παραγωγα ετεροαρυλιου ως διαμορφωτες αλφα7 nachr

Info

Publication number
CY1118107T1
CY1118107T1 CY20161101057T CY161101057T CY1118107T1 CY 1118107 T1 CY1118107 T1 CY 1118107T1 CY 20161101057 T CY20161101057 T CY 20161101057T CY 161101057 T CY161101057 T CY 161101057T CY 1118107 T1 CY1118107 T1 CY 1118107T1
Authority
CY
Cyprus
Prior art keywords
eteroyrum
producers
models
compounds
treatment
Prior art date
Application number
CY20161101057T
Other languages
English (en)
Inventor
Neelima Sinha
Gourhari Jana
Sachchidanand Sachchidanand
Sanjay Pralhad Kurhade
Navnath Popat Karche
Anil Kashiram Hajare
Ajay Ramchandra Tilekar
Venkata P Palle
Rajender Kumar Kamboj
Original Assignee
Lupin Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45873193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118107(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lupin Limited filed Critical Lupin Limited
Publication of CY1118107T1 publication Critical patent/CY1118107T1/el

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Pyrrole Compounds (AREA)

Abstract

Αποκαλύπτεται ένωση του τύπου (I), όπου τα Ζ, m και R1-R6 είναι όπως περιγράφεται στο κείμενο, ως διαμορφωτής νικοτινικών υποδοχέων ακετυλοχολίνης ιδίως του α7 υποτύπου, σε υποκείμενο που τον χρειάζεται, καθώς και ανάλογα, προφάρμακα, ισοτοπικώς υποκατεστημένα ανάλογα, μεταβολίτες, φαρμακευτικώς αποδεκτά άλατα, πολύμορφα, επιδιαλυτωμένα συμπλέγματα, ισομερή, ενώσεις εγκλεισμού και συν-κρύσταλλος αυτής, για χρήση μεμονωμένα ή σε συνδυασμούς με άλλα κατάλληλα φάρμακα, και φαρμακευτικές συνθέσεις που περιέχουν τέτοιες ενώσεις και ανάλογα. Επίσης αποκαλύπτεται διεργασία παρασκευής των ενώσεων και οι προβλεπόμενες χρήσεις αυτών στη θεραπεία, ιδίως στην προφύλαξη και θεραπεία διαταραχών όπως της νόσου του Alzheimer, ήπιας γνωστικής εξασθένησης, γεροντικής άνοιας, και των ομοίων.
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