TN2013000345A1 - Heteroaryl derivatives as alpha7 nachr modulators - Google Patents
Heteroaryl derivatives as alpha7 nachr modulatorsInfo
- Publication number
- TN2013000345A1 TN2013000345A1 TNP2013000345A TN2013000345A TN2013000345A1 TN 2013000345 A1 TN2013000345 A1 TN 2013000345A1 TN P2013000345 A TNP2013000345 A TN P2013000345A TN 2013000345 A TN2013000345 A TN 2013000345A TN 2013000345 A1 TN2013000345 A1 TN 2013000345A1
- Authority
- TN
- Tunisia
- Prior art keywords
- analogues
- therapy
- compounds
- disclosed
- heteroaryl derivatives
- Prior art date
Links
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000027061 mild cognitive impairment Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Disclosed is a compound of formula (I), wherein Z, m and R1 -R6 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the α7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN242KO2011 | 2011-02-23 | ||
| PCT/IB2012/050806 WO2012114285A1 (en) | 2011-02-23 | 2012-02-22 | Heteroaryl derivatives as alpha7 nachr modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2013000345A1 true TN2013000345A1 (en) | 2015-01-20 |
Family
ID=52394780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2013000345A TN2013000345A1 (en) | 2011-02-23 | 2013-08-15 | Heteroaryl derivatives as alpha7 nachr modulators |
Country Status (2)
| Country | Link |
|---|---|
| TN (1) | TN2013000345A1 (en) |
| UA (1) | UA112076C2 (en) |
-
2012
- 2012-02-22 UA UAA201311194A patent/UA112076C2/en unknown
-
2013
- 2013-08-15 TN TNP2013000345A patent/TN2013000345A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA112076C2 (en) | 2016-07-25 |
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