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CY1112176T1 - Υποκατεστημενα παραγωγα οξαζολης με αναλγητικη δραση - Google Patents

Υποκατεστημενα παραγωγα οξαζολης με αναλγητικη δραση

Info

Publication number
CY1112176T1
CY1112176T1 CY20111101210T CY111101210T CY1112176T1 CY 1112176 T1 CY1112176 T1 CY 1112176T1 CY 20111101210 T CY20111101210 T CY 20111101210T CY 111101210 T CY111101210 T CY 111101210T CY 1112176 T1 CY1112176 T1 CY 1112176T1
Authority
CY
Cyprus
Prior art keywords
alkyl
optionally substituted
aryl
optionally
attached
Prior art date
Application number
CY20111101210T
Other languages
English (en)
Inventor
Beatrix Merla
Stefan Oberbörsch
Bernd Sundermann
Werner Englberger
Heinz Graubaum
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1112176T1 publication Critical patent/CY1112176T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε υποκατεστημένα παράγωγα οξαζόλης του τύπου 1, σε μέθοδο για την παραγωγή τους, σε φαρμακευτικά προϊόντα που εμπεριέχουν αυτές τις ενώσεις και στην χρήση των υποκατεστημένων παραγώγων οξαζόλης για την παραγωγή αυτών των φαρμακευτικών προϊόντων.
CY20111101210T 2005-12-22 2011-12-06 Υποκατεστημενα παραγωγα οξαζολης με αναλγητικη δραση CY1112176T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005061429A DE102005061429A1 (de) 2005-12-22 2005-12-22 Substituierte Oxazol-Derivate
EP06841029A EP1963288B1 (de) 2005-12-22 2006-12-19 Substituierte oxazol-derivate mit analgetischer wirkung

Publications (1)

Publication Number Publication Date
CY1112176T1 true CY1112176T1 (el) 2015-12-09

Family

ID=37814593

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111101210T CY1112176T1 (el) 2005-12-22 2011-12-06 Υποκατεστημενα παραγωγα οξαζολης με αναλγητικη δραση

Country Status (17)

Country Link
US (1) US7608619B2 (el)
EP (1) EP1963288B1 (el)
JP (1) JP2009520718A (el)
CN (1) CN101384563B (el)
AT (1) ATE523501T1 (el)
AU (1) AU2006334744B2 (el)
CA (1) CA2634566A1 (el)
CY (1) CY1112176T1 (el)
DE (1) DE102005061429A1 (el)
DK (1) DK1963288T3 (el)
ES (1) ES2370660T3 (el)
IL (1) IL192269A0 (el)
PL (1) PL1963288T4 (el)
PT (1) PT1963288E (el)
RU (1) RU2424236C2 (el)
SI (1) SI1963288T1 (el)
WO (1) WO2007079928A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005061430A1 (de) * 2005-12-22 2007-07-05 Grünenthal GmbH Substituierte Imidazolin-Derivate
TWI450899B (zh) 2008-03-27 2014-09-01 被取代之螺環環已烷衍生物
PL2280941T3 (pl) 2008-03-27 2015-10-30 Gruenenthal Gmbh (Hetero-)arylowe pochodne cykloheksanu
AR074615A1 (es) 2008-03-27 2011-02-02 Gruenenthal Chemie Derivados de 4- aminociclohexano sustituido
JP5542119B2 (ja) 2008-03-27 2014-07-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング スピロ（５．５）ウンデカン誘導体
JP5529843B2 (ja) 2008-03-27 2014-06-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換シクロヘキシルジアミン
WO2009118171A1 (de) 2008-03-27 2009-10-01 Grünenthal GmbH Hydroxymethylcyclohexylamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE19732928C2 (de) * 1997-07-31 2000-05-18 Gruenenthal Gmbh Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
EP0908180A3 (en) * 1997-08-28 1999-04-21 Eli Lilly And Company Use of phenyl oxazole or phenyl thiazole derivatives for treating pain
US5952360A (en) * 1997-08-28 1999-09-14 Eli Lilly And Company Method for treating neuropathic pain
DE19858593A1 (de) * 1998-12-18 2000-06-21 Merck Patent Gmbh Sulfonyloxazolamine als therapeutische Wirkstoffe
US7183276B2 (en) * 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
TW200505446A (en) * 2003-01-17 2005-02-16 Fuj Isawa Pharmaceutical Co Ltd Inhibitor of cox

Also Published As

Publication number Publication date
DK1963288T3 (da) 2011-11-21
PL1963288T4 (pl) 2012-03-30
EP1963288B1 (de) 2011-09-07
AU2006334744B2 (en) 2011-06-16
WO2007079928A1 (de) 2007-07-19
US20090069330A1 (en) 2009-03-12
PT1963288E (pt) 2011-11-04
HK1123297A1 (en) 2009-06-12
CN101384563B (zh) 2012-06-27
RU2424236C2 (ru) 2011-07-20
CA2634566A1 (en) 2007-07-19
ATE523501T1 (de) 2011-09-15
AU2006334744A1 (en) 2007-07-19
CN101384563A (zh) 2009-03-11
RU2008129625A (ru) 2010-02-27
IL192269A0 (en) 2008-12-29
PL1963288T3 (pl) 2012-01-31
US7608619B2 (en) 2009-10-27
SI1963288T1 (sl) 2011-12-30
DE102005061429A1 (de) 2007-06-28
ES2370660T3 (es) 2011-12-21
JP2009520718A (ja) 2009-05-28
EP1963288A1 (de) 2008-09-03

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