[go: up one dir, main page]

PE20081342A1 - Derivados eter como moduladores duales de los receptores de 5-ht2a y d3 - Google Patents

Derivados eter como moduladores duales de los receptores de 5-ht2a y d3

Info

Publication number
PE20081342A1
PE20081342A1 PE2007001497A PE2007001497A PE20081342A1 PE 20081342 A1 PE20081342 A1 PE 20081342A1 PE 2007001497 A PE2007001497 A PE 2007001497A PE 2007001497 A PE2007001497 A PE 2007001497A PE 20081342 A1 PE20081342 A1 PE 20081342A1
Authority
PE
Peru
Prior art keywords
ht2a
fluor
piperidin
phenoxy
trans
Prior art date
Application number
PE2007001497A
Other languages
English (en)
Inventor
Luca Claudio Gobbi
Georg Jaeschke
Olivier Roche
Sarmiento Rosa Maria Rodriguez
Lucinda Steward
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38962066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081342(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20081342A1 publication Critical patent/PE20081342A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE PIPERIDINA DE FORMULA (I), DONDE A ES ARILO O HETEROARILO DE 5 A 12 MIEMBROS , OPCIONALMENTE SUSTITUIDOS CON CIANO, ALCOXI C1-C6, ENTRE OTROS; R1 ES ALQUILO C1-C6, CICLOALQUILO C3-C10, HETEROARILO DE 5 A 12 MIEMBROS, ENTRE OTROS; R2 ES H U OH. SON COMPUESTOS PREFERIDOS: N-TRANS (4-{2-[4-(4-FLUOR-FENOXI)-PIPERIDIN-1-IL]-ETIL}-CICLO-HEXIL)-3-METOXI-PROPIONAMIDA, N-TRANS(4-{2-[4-(4-FLUOR-FENOXI)-PIPERIDIN-1-IL]-ETIL}-CICLO-HEXIL)-ACETAMIDA, N-TRANS(4-{2-[4-(2-CLORO-4-FLUOR-FENOXI)-PIPERIDIN-1-IL]-ETIL-CICLOHEXIL)-3-METOXI-PROPIONAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCESO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DUALES DE LOS RECEPTORES DE SEROTONINA 5-HT2a Y DOPAMINA D3 Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS PSICOTICOS, DEPRESION, ANSIEDAD, ENTRE OTROS
PE2007001497A 2006-10-31 2007-10-31 Derivados eter como moduladores duales de los receptores de 5-ht2a y d3 PE20081342A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06123274 2006-10-31

Publications (1)

Publication Number Publication Date
PE20081342A1 true PE20081342A1 (es) 2008-09-18

Family

ID=38962066

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001497A PE20081342A1 (es) 2006-10-31 2007-10-31 Derivados eter como moduladores duales de los receptores de 5-ht2a y d3

Country Status (18)

Country Link
US (1) US7795437B2 (es)
EP (1) EP2079693B1 (es)
JP (1) JP5087631B2 (es)
KR (1) KR101114651B1 (es)
CN (1) CN101535258B (es)
AR (1) AR063438A1 (es)
AU (1) AU2007316249B2 (es)
BR (1) BRPI0718127A2 (es)
CA (1) CA2667511A1 (es)
CL (1) CL2007003110A1 (es)
ES (1) ES2401663T3 (es)
IL (1) IL198157A0 (es)
MX (1) MX2009004615A (es)
NO (1) NO20091675L (es)
PE (1) PE20081342A1 (es)
RU (1) RU2009116509A (es)
TW (1) TW200826940A (es)
WO (1) WO2008052899A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2480466C2 (ru) * 2007-07-26 2013-04-27 Ф.Хоффманн-Ля Рош Аг Двойные модуляторы 5-ht2a и d3-рецепторов
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
WO2011060363A2 (en) * 2009-11-16 2011-05-19 Auspex Pharmaceuticals, Inc. Cyclohexyl urea modulators of d2 receptors and/or d3 receptors
US8877778B2 (en) 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8722683B2 (en) * 2011-02-17 2014-05-13 Hoffmann La-Roche Inc. Benzodioxole piperazine compounds
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1514718A (en) 1974-08-15 1978-06-21 Ferrosan Ab Diphenyl-butylpiperidines
US4024264A (en) * 1974-08-15 1977-05-17 Ab Ferrosan Diphenylbutylpiperidines
JP2860689B2 (ja) 1990-03-14 1999-02-24 第一製薬株式会社 ピリミジン誘導体
US5229400A (en) 1990-10-05 1993-07-20 Ajinomoto Co., Inc. Piperidine compounds and their use as antiarrhythmic agents
PL350904A1 (en) 1999-03-26 2003-02-10 Astrazeneca Ab Novel compounds
HUP0103986A2 (hu) 2001-09-28 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
MXPA04006599A (es) 2001-12-04 2004-12-07 Actelion Pharmaceuticals Ltd 4-(piperidilo y pirrolidilo-aquilo-ureido)-quinolinas como antagonistas receptores de urotensina ii.
EP1348434A1 (en) 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Use of pyridyl amides as inhibitors of angiogenesis
WO2004063181A1 (en) 2003-01-03 2004-07-29 Genzyme Corporation Urea derivatives and their use as anti-inflammatory agents
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA2667511A1 (en) 2008-05-08
CN101535258B (zh) 2012-12-05
EP2079693A1 (en) 2009-07-22
RU2009116509A (ru) 2010-12-10
MX2009004615A (es) 2009-05-22
US20080103174A1 (en) 2008-05-01
BRPI0718127A2 (pt) 2014-02-18
JP2010508319A (ja) 2010-03-18
CN101535258A (zh) 2009-09-16
JP5087631B2 (ja) 2012-12-05
TW200826940A (en) 2008-07-01
IL198157A0 (en) 2009-12-24
EP2079693B1 (en) 2013-02-27
KR101114651B1 (ko) 2012-06-12
US7795437B2 (en) 2010-09-14
AU2007316249A1 (en) 2008-05-08
AU2007316249B2 (en) 2013-01-24
CL2007003110A1 (es) 2008-06-13
NO20091675L (no) 2009-05-28
KR20090075848A (ko) 2009-07-09
WO2008052899A1 (en) 2008-05-08
ES2401663T3 (es) 2013-04-23
AR063438A1 (es) 2009-01-28

Similar Documents

Publication Publication Date Title
PE20090892A1 (es) MODULADORES DUALES DE LOS RECEPTORES 5-HT2a Y D3
CO6341581A2 (es) Derivados de heteroarilo como inhibidores de dgat1
PE20130155A1 (es) Derivados de ariletinilo
PE20071152A1 (es) Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3
PE20081342A1 (es) Derivados eter como moduladores duales de los receptores de 5-ht2a y d3
NO20084783L (no) Syntese av acylaminoalkenylenamider nyttige som substans P antagonister
AR053415A1 (es) Inhibidores dipeptidil peptidasa iv, composiciones farmaceuticas que los contienen y procesos para la preparacion de los compuestos y de la composicion
AR038419A1 (es) Derivados de piridina y quinolina
PE20081679A1 (es) Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
AR078756A1 (es) Moduladores alostericos positivos (map)
PE20141556A1 (es) Derivados de etinilo como moduladores alostericos de mglur5
PE20140934A1 (es) Derivados de pirazol
PE20140968A1 (es) Derivados de benzamida sustituida
PE20141380A1 (es) Imidazopiridazinas como inhibidores de quinasa akt
AR041395A1 (es) Compuesto de piridina composicion farmaceutica que lo comprende y su uso para prepararla
PE20120657A1 (es) Compuesto para el tratamiento de trastornos metabolicos
CO6321269A2 (es) Derivados de benzoxazinona que actuan como agonistas de receptores adrenergicos beta 2 para el tratamiento de transtornos respiratorios
PE20061490A1 (es) Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1
AR056103A1 (es) Compuestos de(piran-piperidinil)benzimidazol, composiciones farmaceuticas que los comprenden, proceso de preparacion y usos en el tratamiento de afecciones mediadas por agonistas del receptor muscarinico m1
AR077301A1 (es) Derivados de 2-carboxamida-7-piperazinil-benzofurano como antagonistas de 5-ht1a y 5-ht1b
PE20061144A1 (es) DERIVADOS DE PIRROLIDINA Y PIPERIDINA ACETILENO COMO ANTAGONISTAS DE LOS RECEPTORES DE GLUTAMATO METABOTROPICO (mGluRs)
PE20090513A1 (es) Derivados de benzoil-piperidina como moduladores duales de receptores de 5-ht2a y de d3
PE20091182A1 (es) DERIVADOS DE IMIDAZO[1,2-a]PIRIDIN-2-CARBOXAMIDAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA
CR10207A (es) "derivados de acido acético benzo (f) isoindol-2-ilfenil como receptores agonistas de ep4"
PE20050293A1 (es) Derivados de aminoacidos sustituidos con cicloalquilo, procedimiento para su preparacion y su uso como medicamentos

Legal Events

Date Code Title Description
FC Refusal