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CU24304B1 - Formulación de fármaco de liberación retardada - Google Patents

Formulación de fármaco de liberación retardada

Info

Publication number
CU24304B1
CU24304B1 CUP2014000123A CU20140123A CU24304B1 CU 24304 B1 CU24304 B1 CU 24304B1 CU P2014000123 A CUP2014000123 A CU P2014000123A CU 20140123 A CU20140123 A CU 20140123A CU 24304 B1 CU24304 B1 CU 24304B1
Authority
CU
Cuba
Prior art keywords
outer layer
core
polymeric material
layer
drug
Prior art date
Application number
CUP2014000123A
Other languages
English (en)
Other versions
CU20140123A7 (es
Inventor
Abdul Waseh Basit
González Roberto Carlos Bravo
Thomas Buser
Ana Cristina Freire
Frédéric Jean-Claude Goutte
Felipe José Oliveria Varum
Original Assignee
Tillotts Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46025554&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24304(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tillotts Pharma Ag filed Critical Tillotts Pharma Ag
Publication of CU20140123A7 publication Critical patent/CU20140123A7/es
Publication of CU24304B1 publication Critical patent/CU24304B1/es

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/60—Salicylic acid; Derivatives thereof
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    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/2833—Organic macromolecular compounds
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Laminated Bodies (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Grain Derivatives (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

<p>La liberación retardada de un fármaco al colon se logra de una formulación de liberación retardada que comprende un núcleo y un recubrimiento para el núcleo. El núcleo comprende un fármaco y un recubrimiento que comprende: (I) una capa exterior y una capa de aislamiento entre el núcleo y la capa externa, o, (II) una capa exterior y una capa interior entre el núcleo y la capa externa, o (III) una capa exterior y tanto una capa de aislamiento como una capa interior entre el núcleo y la capa exterior. La capa exterior comprende una mezcla de un primer material polimérico que es susceptible a ataques por parte de la bacteria colónica, y un segundo material polimérico que tiene un umbral de pH en el intervalo de pH 6 a 8. La capa interior comprende un tercer material polimérico que es soluble en el fluido intestinal o en el fluido gastrointestinal, tal tercer material polimérico es un ácido policarboxílico que está al menos parcialmente neutralizado con 10% a 100% de los grupos ácido carboxílico de dicho polímero de ácido policarboxílico en forma de aniones carboxilato. La capa de aislamiento comprende un polímero no iónico que es soluble en el fluido intestinal o fluido gastrointestinal. La capa exterior se aplica directamente a la capa interior o la capa de aislamiento usando una preparación de recubrimiento formada por la combinación del primer material polimérico en medio acuoso con un segundo material polimérico en un medio orgánico. Las ventajas de las formulaciones de acuerdo con la presente invención incluyen la liberación acelerada del fármaco cuando se expone a condiciones colónicas y la reducción o eliminación del efecto de los alimentos y/o alcohol en la liberación del fármaco después de la administración.</p>
CUP2014000123A 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada CU24304B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261640217P 2012-04-30 2012-04-30
EP12166110.2A EP2659881B1 (en) 2012-04-30 2012-04-30 A delayed release drug formulation
PCT/EP2013/058923 WO2013164316A1 (en) 2012-04-30 2013-04-29 A delayed release drug formulation

Publications (2)

Publication Number Publication Date
CU20140123A7 CU20140123A7 (es) 2015-02-26
CU24304B1 true CU24304B1 (es) 2018-01-10

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CUP2014000123A CU24304B1 (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada

Country Status (41)

Country Link
US (6) US9364440B2 (es)
EP (6) EP2659881B1 (es)
JP (2) JP6621662B2 (es)
KR (6) KR102102198B1 (es)
CN (5) CN104302274A (es)
AR (1) AR090898A1 (es)
AU (4) AU2013255914B2 (es)
BR (3) BR112014026933B1 (es)
CA (4) CA3080035A1 (es)
CL (2) CL2014002795A1 (es)
CO (2) CO7151506A2 (es)
CR (4) CR20190246A (es)
CU (1) CU24304B1 (es)
CY (4) CY1120215T1 (es)
DK (5) DK2659881T3 (es)
EA (2) EA032811B1 (es)
ES (6) ES2655622T3 (es)
GE (4) GEP201706759B (es)
HR (2) HRP20180068T1 (es)
HU (5) HUE036187T2 (es)
JO (6) JOP20200144A1 (es)
LT (5) LT2659881T (es)
ME (2) ME03364B (es)
MX (4) MX362529B (es)
MY (3) MY169161A (es)
NO (1) NO2659881T3 (es)
NZ (3) NZ725409A (es)
PE (3) PE20190625A1 (es)
PH (2) PH12014502339A1 (es)
PL (5) PL2659881T3 (es)
PT (5) PT2659881T (es)
RS (5) RS56839B1 (es)
SA (2) SA115370043B1 (es)
SG (2) SG11201406798WA (es)
SI (5) SI2659881T1 (es)
SM (5) SMT201800095T1 (es)
TN (2) TN2014000442A1 (es)
TR (3) TR201905226T4 (es)
TW (3) TWI618547B (es)
UY (1) UY34772A (es)
WO (2) WO2013164315A1 (es)

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HRP20190470T1 (hr) * 2012-04-30 2019-05-17 Tillotts Pharma Ag Formulacija lijeka s odgođenim otpuštanjem
US20140141075A1 (en) 2012-11-21 2014-05-22 Warner Chilcott Company, Llc 5-aminosalicylic acid capsule formulation
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WO2018102469A1 (en) * 2016-11-30 2018-06-07 Xeno Biosciences Inc. Pharmaceutical preparations and methods to manage weight and to modulate the gut microbiota
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