[go: up one dir, main page]

CU24266B1 - Miméticos de apelina sintéticos para el tratamiento de insuficiencia cardíaca - Google Patents

Miméticos de apelina sintéticos para el tratamiento de insuficiencia cardíaca

Info

Publication number
CU24266B1
CU24266B1 CUP2014000097A CU20140097A CU24266B1 CU 24266 B1 CU24266 B1 CU 24266B1 CU P2014000097 A CUP2014000097 A CU P2014000097A CU 20140097 A CU20140097 A CU 20140097A CU 24266 B1 CU24266 B1 CU 24266B1
Authority
CU
Cuba
Prior art keywords
aib
isn
cha
amino
nle
Prior art date
Application number
CUP2014000097A
Other languages
English (en)
Spanish (es)
Other versions
CU20140097A7 (es
Inventor
Andrei Golosov
Philipp Grosche
Qi-Ying Hu
Hidetomo Imase
David Thomas Parker
Kayo Yasoshima
Frédéric Zecri
Hongjuan Zhao
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47997598&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24266(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20140097A7 publication Critical patent/CU20140097A7/es
Publication of CU24266B1 publication Critical patent/CU24266B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816—Joints or connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A61M16/0066—Blowers or centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/201—Controlled valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
CUP2014000097A 2012-01-27 2013-01-25 Miméticos de apelina sintéticos para el tratamiento de insuficiencia cardíaca CU24266B1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261591557P 2012-01-27 2012-01-27
US201261717760P 2012-10-24 2012-10-24
US201261731697P 2012-11-30 2012-11-30
PCT/IB2013/050666 WO2013111110A2 (fr) 2012-01-27 2013-01-25 Utilisation de mimétiques synthétiques de l'apeline pour le traitement de l'insuffisance cardiaque

Publications (2)

Publication Number Publication Date
CU20140097A7 CU20140097A7 (es) 2015-03-30
CU24266B1 true CU24266B1 (es) 2017-07-04

Family

ID=47997598

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2014000097A CU24266B1 (es) 2012-01-27 2013-01-25 Miméticos de apelina sintéticos para el tratamiento de insuficiencia cardíaca

Country Status (42)

Country Link
US (3) US8673848B2 (fr)
EP (1) EP2807183B1 (fr)
JP (2) JP6313222B2 (fr)
KR (2) KR20200003229A (fr)
CN (1) CN104220452B (fr)
AP (1) AP2014007846A0 (fr)
AR (1) AR089808A1 (fr)
AU (1) AU2013213265C1 (fr)
BR (1) BR112014018306A8 (fr)
CA (1) CA2862240A1 (fr)
CL (1) CL2014001994A1 (fr)
CO (1) CO7020879A2 (fr)
CR (1) CR20140364A (fr)
CU (1) CU24266B1 (fr)
CY (1) CY1120239T1 (fr)
DK (1) DK2807183T3 (fr)
EA (1) EA027853B1 (fr)
EC (1) ECSP14016014A (fr)
ES (1) ES2670832T3 (fr)
GT (1) GT201400166A (fr)
HR (1) HRP20180806T1 (fr)
HU (1) HUE039137T2 (fr)
IL (1) IL233792B (fr)
JO (1) JO3380B1 (fr)
LT (1) LT2807183T (fr)
MX (1) MX351569B (fr)
MY (1) MY172268A (fr)
NZ (1) NZ627772A (fr)
PE (1) PE20142194A1 (fr)
PH (1) PH12014501701A1 (fr)
PL (1) PL2807183T3 (fr)
PT (1) PT2807183T (fr)
RS (1) RS57200B1 (fr)
SG (1) SG11201404369PA (fr)
SI (1) SI2807183T1 (fr)
TN (1) TN2014000318A1 (fr)
TR (1) TR201807309T4 (fr)
TW (1) TWI576356B (fr)
UA (1) UA116196C2 (fr)
UY (1) UY34593A (fr)
WO (1) WO2013111110A2 (fr)
ZA (1) ZA201405400B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
UY35144A (es) * 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
US8921307B2 (en) * 2012-11-20 2014-12-30 Novartis Ag Synthetic linear apelin mimetics for the treatment of heart failure
IN2015DN02913A (fr) 2012-11-30 2015-09-18 Novartis Ag
WO2014099984A1 (fr) * 2012-12-20 2014-06-26 Amgen Inc. Agonistes du récepteur apj et leurs utilisations
MX365551B (es) 2013-03-14 2019-06-07 Regeneron Pharma Proteinas de fusion de apelina y usos de estas.
HK1218252A1 (zh) * 2013-07-25 2017-02-10 Novartis Ag 合成apelin多肽之生物结合物
KR20160031551A (ko) 2013-07-25 2016-03-22 노파르티스 아게 심부전의 치료를 위한 시클릭 폴리펩티드
CN105612173A (zh) * 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的环状apelin衍生物
CN105612174A (zh) * 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的二硫化物环状多肽
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
KR20160086942A (ko) 2013-11-20 2016-07-20 리제너론 파아마슈티컬스, 인크. Ａｐｌｎｒ 조절물질 및 이들의 용도
AU2014356126B2 (en) * 2013-11-26 2017-01-05 Novartis Ag Methods for oxime conjugation to ketone-modified polypeptides
WO2015089137A1 (fr) 2013-12-11 2015-06-18 Karos Pharmaceuticals, Inc. Acylguanidines comme inhibiteurs de la tryptophan hydroxylase
AU2015237357B2 (en) * 2014-03-25 2019-04-18 Lanthiopep B.V. Cyclic apelin analogs
GB201407532D0 (en) 2014-04-29 2014-06-11 Univ Ulster Apelin analogues
US10406198B2 (en) 2014-05-23 2019-09-10 Novartis Ag Methods for making conjugates from disulfide-containing proteins
ES2818109T3 (es) 2014-06-23 2021-04-09 Novartis Ag Modificaciones de proteínas específicas para un sitio
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
WO2016109501A1 (fr) 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Composés amides utilisés en tant qu'inhibiteurs de la tryptophane hydroxylase
CR20170338A (es) * 2015-01-23 2017-09-12 Novartis Ag Conjugados de ácidos grasos y apelina sintética con mayor vida media
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
US10426818B2 (en) * 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
HRP20200690T1 (hr) 2015-05-20 2020-07-24 Amgen Inc. Agonisti triazola apj receptora
EP3416688B1 (fr) 2016-02-15 2022-08-17 INSERM - Institut National de la Santé et de la Recherche Médicale Apelin pour son utilisation dans le traitement d'un dysfonctionnement cognitif postopératoire
WO2017192485A1 (fr) 2016-05-03 2017-11-09 Amgen Inc. Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj
JP7200100B2 (ja) 2016-10-19 2023-01-06 アバイブ， インコーポレイテッド 心臓血管系疾患の処置のためのアペリンの新規ペグ化リポソーム製剤
WO2018093579A1 (fr) 2016-11-16 2018-05-24 Amgen Inc. Composés phényle triazole en tant qu'agonistes du récepteur apj
MA46827A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj
EP3541805B1 (fr) 2016-11-16 2020-10-14 Amgen Inc. Triazoles substitués par hétéroaryle utilisés en tant qu'agonistes du récepteur apj
WO2018097944A1 (fr) 2016-11-16 2018-05-31 Amgen Inc. Composés de triazole furane utilisés en tant qu'agonistes du récepteur apj
MA46824A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
WO2018093580A1 (fr) 2016-11-16 2018-05-24 Amgen Inc. Composés de triazole pyridyle en tant qu'agonistes du récepteur apj
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
EP4092038A1 (fr) 2017-09-11 2022-11-23 Protagonist Therapeutics, Inc. Peptides d'agoniste opioïde et leurs utilisations
MA50509A (fr) 2017-11-03 2021-06-02 Amgen Inc Agonistes de triazole fusionnés du récepteur apj
US11807624B2 (en) 2018-05-01 2023-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the APJ receptor
WO2020037100A1 (fr) 2018-08-16 2020-02-20 Isolere Bio, Inc. Polypeptide génétiquement codé pour la capture et la purification par affinité de produits biologiques
CN113227093A (zh) 2018-11-14 2021-08-06 阿尔塔万特科学公司 结晶螺环化合物、包含该化合物的剂型、用于疾病治疗的方法和再结晶方法
CN112007027B (zh) * 2020-09-14 2022-07-15 长春金赛药业有限责任公司 含酯基芳香丙酰胺类化合物及其代谢产物在制备治疗心衰药物中的应用
CN119101143A (zh) * 2023-05-31 2024-12-10 浙江大学 一种G蛋白偏向的apelin-13多肽突变体及应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69317883T2 (de) 1992-11-17 1998-11-12 Icos Corp., Bothell, Wash. Neue Sieben-Transmembran-Rezeptor V28
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
AU1685499A (en) 1997-12-24 1999-07-19 Takeda Chemical Industries Ltd. Polypeptide, their production and use
AU5759399A (en) 1998-09-25 2000-04-17 Takeda Chemical Industries Ltd. Peptide derivative
CA2346064A1 (fr) 1998-10-05 2000-04-13 Takeda Chemical Industries, Ltd. Procede d'elimination de methionine n-terminale
US7045532B2 (en) 1999-04-30 2006-05-16 Millennium Pharmaceuticals, Inc. ACE-2 modulating compounds and methods of use thereof
CA2403447A1 (fr) 2000-03-23 2001-09-27 Takeda Chemical Industries, Ltd. Derive peptidique
AU2001264937A1 (en) 2000-05-23 2001-12-03 Genaissance Pharmaceuticals, Inc. Haplotypes of the agtrl1 gene
ES2320431T3 (es) 2001-07-16 2009-05-22 Caprotec Bioanalytics Gmbh Compuestos de captura, colecciones de los mismos y metodos para analizar el proteoma y composiciones complejas.
WO2003063892A1 (fr) 2002-01-29 2003-08-07 Takeda Chemical Industries, Ltd. Utilisation d'apeline
ATE471722T1 (de) 2003-03-12 2010-07-15 Univ Arizona State Verfahren zur regulierung von angiogenese mit apelin-zusammensetzungen
WO2005029066A2 (fr) 2003-05-22 2005-03-31 Agilent Technologies, Inc. Marqueurs de diagnostic et cibles pharmacologiques utilises dans l'insuffisance cardiaque, et reactifs connexes et leurs procedes d'utilisation
US7947280B2 (en) 2003-05-22 2011-05-24 The Board Of Trustees Of The Leland Stanford Junior University Apelin and uses thereof
EP1520861A1 (fr) 2003-09-11 2005-04-06 Aventis Pharma Deutschland GmbH Système d'essai pour l'identification des ligands du recepteur APJ
WO2005106493A1 (fr) 2004-04-30 2005-11-10 Bayer Healthcare Ag Diagnostics et therapies pour maladies associees au recepteur de l'apeline couplee a une proteine g (apj)
CA2573109A1 (fr) 2004-06-17 2006-01-26 Thomas A. Dix Acides amines non naturels
WO2006023893A2 (fr) 2004-08-23 2006-03-02 Arizona Board Of Regents On Behalf Of The University Of Arizona Methodes de modulation de l'angiogenese et de l'apoptose, dans lesquelles sont utilisees des compositions a base d'apeline
JP2008013436A (ja) 2004-10-14 2008-01-24 Kanazawa Univ 血管形成促進剤
US20110097710A1 (en) 2004-10-26 2011-04-28 Macrae Calum A Methods for detecting atrial fibrillation and related conditions
US20060159676A1 (en) 2005-01-14 2006-07-20 Krieg Paul A Methods for modulating angiogenesis, lymphangiogenesis, and apoptosis with apelin compositions
EP2330125A3 (fr) 2005-08-11 2012-12-12 Amylin Pharmaceuticals, Inc. Polypeptides hybrides ayant des propriétés sélectionnables
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
EP1876448A1 (fr) 2005-09-30 2008-01-09 DIGILAB BioVisioN GmbH Méthodes et réactifs analytiques pour identifier des médicaments à l'aide de marqueurs biologiques sensibles aux thiazolidinediones
US7736346B2 (en) 2005-10-18 2010-06-15 Biocardia, Inc. Bio-interventional therapeutic treatments for cardiovascular diseases
US20080031871A1 (en) 2006-02-21 2008-02-07 Allen Margaret L Memory and learning impairments associated with disruption of Ephrin receptor A6 (EphA6) gene
EP2017355A4 (fr) 2006-04-25 2010-01-06 Univ Kyushu Nat Univ Corp Gène associé à une maladie artérioscléreuse et utilisation de celui-ci
WO2009033711A2 (fr) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Utilisation d'un peptide comme agent thérapeutique
WO2009033819A2 (fr) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Utilisation d'un peptide en tant qu'agent thérapeutique
US20110123534A1 (en) 2007-12-12 2011-05-26 Erasmus University Medical Center Rotterdam Novel compounds for modulating neovascularisation and methods of treatment using these compounds
WO2009075566A1 (fr) 2007-12-12 2009-06-18 Erasmus University Medical Center Rotterdam Biomarqueurs pour maladie cardiovasculaire
EP2362878A4 (fr) 2008-11-04 2015-09-16 Anchor Therapeutics Inc Composés de récepteur apj
WO2010115874A1 (fr) 2009-04-07 2010-10-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés pour le traitement et le diagnostic d'une hypertension artérielle pulmonaire
EP2496243A2 (fr) 2009-11-04 2012-09-12 Erasmus University Medical Center Rotterdam Nouveaux composés pour la modulation de la néo-vascularisation et methodés de traitement utilisant ces composés
WO2011133948A2 (fr) 2010-04-22 2011-10-27 Longevity Biotech, Inc. Polypeptides très actifs et procédés pour les préparer et les utiliser
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
RU2457216C1 (ru) 2010-12-21 2012-07-27 Федеральное государственное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "РКНПК" Минздравсоцразвития России) Додекапептиды, обладающие кардиопротекторными свойствами
CA2860740A1 (fr) 2012-01-09 2013-07-18 Anchor Therapeutics, Inc. Composes de recepteurs apj
KR20160031551A (ko) 2013-07-25 2016-03-22 노파르티스 아게 심부전의 치료를 위한 시클릭 폴리펩티드
CN105612173A (zh) 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的环状apelin衍生物
CN105612174A (zh) 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的二硫化物环状多肽
HK1218252A1 (zh) 2013-07-25 2017-02-10 Novartis Ag 合成apelin多肽之生物结合物

Also Published As

Publication number Publication date
HRP20180806T1 (hr) 2018-06-29
NZ627772A (en) 2015-11-27
MX351569B (es) 2017-10-19
JP6595553B2 (ja) 2019-10-23
CL2014001994A1 (es) 2014-11-03
CY1120239T1 (el) 2019-07-10
US8673848B2 (en) 2014-03-18
US20130196899A1 (en) 2013-08-01
MX2014009085A (es) 2014-08-27
CA2862240A1 (fr) 2013-08-01
TWI576356B (zh) 2017-04-01
DK2807183T3 (en) 2018-06-06
JP6313222B2 (ja) 2018-04-18
SI2807183T1 (en) 2018-05-31
BR112014018306A2 (fr) 2017-06-20
KR102068370B1 (ko) 2020-01-21
GT201400166A (es) 2015-10-15
TR201807309T4 (tr) 2018-06-21
ECSP14016014A (es) 2015-11-30
WO2013111110A2 (fr) 2013-08-01
AP2014007846A0 (en) 2014-08-31
TW201335190A (zh) 2013-09-01
JO3380B1 (ar) 2019-03-13
PL2807183T3 (pl) 2018-08-31
IL233792B (en) 2018-04-30
KR20200003229A (ko) 2020-01-08
PE20142194A1 (es) 2014-12-21
PT2807183T (pt) 2018-05-29
CO7020879A2 (es) 2014-08-11
RS57200B1 (sr) 2018-07-31
US20140142022A1 (en) 2014-05-22
US9067971B2 (en) 2015-06-30
LT2807183T (lt) 2018-05-10
UA116196C2 (uk) 2018-02-26
HK1200470A1 (en) 2015-08-07
EA027853B1 (ru) 2017-09-29
KR20140117603A (ko) 2014-10-07
AU2013213265B2 (en) 2016-05-26
MY172268A (en) 2019-11-20
HUE039137T2 (hu) 2018-12-28
CN104220452B (zh) 2018-01-26
TN2014000318A1 (en) 2015-12-21
EP2807183A2 (fr) 2014-12-03
WO2013111110A3 (fr) 2013-10-31
US20150252076A1 (en) 2015-09-10
CR20140364A (es) 2014-11-17
CU20140097A7 (es) 2015-03-30
BR112014018306A8 (pt) 2017-07-11
US9982017B2 (en) 2018-05-29
AU2013213265C1 (en) 2016-09-29
ZA201405400B (en) 2016-08-31
SG11201404369PA (en) 2014-08-28
IL233792A0 (en) 2014-09-30
ES2670832T3 (es) 2018-06-01
PH12014501701A1 (en) 2014-10-13
JP2018048157A (ja) 2018-03-29
AU2013213265A1 (en) 2014-09-18
UY34593A (es) 2013-09-02
EA201491433A1 (ru) 2014-12-30
AR089808A1 (es) 2014-09-17
EP2807183B1 (fr) 2018-02-28
JP2015506370A (ja) 2015-03-02
CN104220452A (zh) 2014-12-17

Similar Documents

Publication Publication Date Title
CU24266B1 (es) Miméticos de apelina sintéticos para el tratamiento de insuficiencia cardíaca
UY35144A (es) Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
PH12016500103A1 (en) Bioconjugates of synthetic apelin polypeptides
SV2016005145A (es) Polipéptidos cíclicos para el tratamiento de la insuficiencia cardiaca
JP2015506370A5 (fr)
JP2016527249A5 (fr)
BR112014013140A8 (pt) cosmética de prótese
MX384378B (es) Dosificación terapéutica de una neurorregulina o una subsecuencia de la misma para el tratamiento o profilaxis de la falla cardiaca.
PE20171328A1 (es) Conjugados de acidos grasos y apelina sintetica con mayor vida media
AU2013288383A8 (en) Popelova, AndreaLipidated peptides as anti-obesity agents
ECSP12011627A (es) Otamixaban para el tratamiento de pacientes con alteración renal y de edad avanzada con infarto de miocardio sin elevación del st
JP2017502089A5 (fr)
TN2016000029A1 (en) Bioconjugates of synthetic apelin polypeptides
Popov et al. Polyfunctional pharmacological properties of collagen peptides from marine echinoderms