[go: up one dir, main page]

CU24712B1 - Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva - Google Patents

Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

Info

Publication number
CU24712B1
CU24712B1 CU2019000021A CU20190021A CU24712B1 CU 24712 B1 CU24712 B1 CU 24712B1 CU 2019000021 A CU2019000021 A CU 2019000021A CU 20190021 A CU20190021 A CU 20190021A CU 24712 B1 CU24712 B1 CU 24712B1
Authority
CU
Cuba
Prior art keywords
cells
lymphocytes
adoptive transfer
differentiation
expansion
Prior art date
Application number
CU2019000021A
Other languages
English (en)
Other versions
CU20190021A7 (es
Inventor
Osorio Ángel De Jesús Corria
George Coukos
Elisabetta Cribioli
Melita Irving
Monzón Kalet León
Bereau Galia Magela Montalvo
Miranda Yaquelín Ortiz
Original Assignee
Centre Hospitalier Univ Vaudois
Ct Inmunologia Molecular
Ludwig Inst For Cancer Res Ltd
Univ Of Lausanne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Hospitalier Univ Vaudois, Ct Inmunologia Molecular, Ludwig Inst For Cancer Res Ltd, Univ Of Lausanne filed Critical Centre Hospitalier Univ Vaudois
Priority to CU2019000021A priority Critical patent/CU24712B1/es
Priority to CN202080020973.5A priority patent/CN113785048B/zh
Priority to EP20757209.0A priority patent/EP3940063A2/en
Priority to US17/439,293 priority patent/US20220152107A1/en
Priority to MX2021011120A priority patent/MX2021011120A/es
Priority to BR112021018100A priority patent/BR112021018100A2/pt
Priority to MYPI2021005276A priority patent/MY206651A/en
Priority to KR1020217033073A priority patent/KR20220012224A/ko
Priority to PCT/CU2020/050002 priority patent/WO2020187340A2/es
Priority to AU2020242520A priority patent/AU2020242520B2/en
Priority to SG11202109574Q priority patent/SG11202109574QA/en
Priority to EA202192447A priority patent/EA202192447A1/ru
Priority to CA3133736A priority patent/CA3133736A1/en
Priority to JP2021555590A priority patent/JP7572371B2/ja
Priority to TW109108199A priority patent/TW202102667A/zh
Priority to ARP200100724A priority patent/AR118369A1/es
Publication of CU20190021A7 publication Critical patent/CU20190021A7/es
Priority to CONC2021/0013127A priority patent/CO2021013127A2/es
Priority to ZA2021/07758A priority patent/ZA202107758B/en
Publication of CU24712B1 publication Critical patent/CU24712B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2312—Interleukin-12 (IL-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2317—Interleukin-17 (IL-17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2321—Interleukin-21 (IL-21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)

Abstract

<p>En la presente invención se describe un método para obtener linfocitos T y células NK con el fenotipo deseado en la transferencia adoptiva de células para la terapia del cáncer. Especialmente, se basa en estrategias para inducir una señalización preferencial a través del receptor de IL2 de afinidad intermedia, con lo cual se logra expandir las células con el fenotipo de memoria central deseado. El método de la presente invención es útil en la obtención de linfocitos infiltrantes de tumor, TCR o de receptores quiméricos ingenierizados de células T empleados en el tratamiento del cáncer.</p>
CU2019000021A 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva CU24712B1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CU2019000021A CU24712B1 (es) 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
AU2020242520A AU2020242520B2 (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of T lymphocytes and NK cells in adoptive transfer therapies
SG11202109574Q SG11202109574QA (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies
US17/439,293 US20220152107A1 (en) 2019-03-15 2020-03-09 Method for expansion and differentiation of t lymphocytes and nk cells for adoptive transfer therapies
MX2021011120A MX2021011120A (es) 2019-03-15 2020-03-09 Metodo para la expansion y diferenciacion de linfocitos t y celulas nk en terapias de transferencia adoptiva.
BR112021018100A BR112021018100A2 (pt) 2019-03-15 2020-03-09 Métodos para a diferenciação e expansão de linfócitos t e células nk, para enriquecimento e expansão ex vivo de linfócitos e para tratar um câncer, uso do método, células, e, composição de células
MYPI2021005276A MY206651A (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies
KR1020217033073A KR20220012224A (ko) 2019-03-15 2020-03-09 입양 전달 요법에서 t 림프구 및 nk 세포의 확장 및 분화를 위한 방법
PCT/CU2020/050002 WO2020187340A2 (es) 2019-03-15 2020-03-09 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
CN202080020973.5A CN113785048B (zh) 2019-03-15 2020-03-09 用于扩增和分化在过继转移疗法中的t淋巴细胞和nk细胞的方法
EP20757209.0A EP3940063A2 (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies
EA202192447A EA202192447A1 (ru) 2019-03-15 2020-03-09 Способ размножения и дифференцировки т-лимфоцитов и nk-клеток в методах лечения с адоптивным переносом
CA3133736A CA3133736A1 (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies
JP2021555590A JP7572371B2 (ja) 2019-03-15 2020-03-09 養子移入療法（Ａｄｏｐｔｉｖｅ ｔｒａｎｓｆｅｒ ｔｈｅｒａｐｉｅｓ）におけるＴリンパ球及びＮＫ細胞の拡大増殖及び分化のための方法
TW109108199A TW202102667A (zh) 2019-03-15 2020-03-12 用於擴增和分化供過繼性細胞治療之ｔ淋巴細胞和天然殺手（ｎｋ）細胞之方法
ARP200100724A AR118369A1 (es) 2019-03-15 2020-03-13 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
CONC2021/0013127A CO2021013127A2 (es) 2019-03-15 2021-09-30 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
ZA2021/07758A ZA202107758B (en) 2019-03-15 2021-10-13 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU2019000021A CU24712B1 (es) 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

Publications (2)

Publication Number Publication Date
CU20190021A7 CU20190021A7 (es) 2020-10-20
CU24712B1 true CU24712B1 (es) 2024-07-10

Family

ID=72087852

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2019000021A CU24712B1 (es) 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

Country Status (18)

Country Link
US (1) US20220152107A1 (es)
EP (1) EP3940063A2 (es)
JP (1) JP7572371B2 (es)
KR (1) KR20220012224A (es)
CN (1) CN113785048B (es)
AR (1) AR118369A1 (es)
AU (1) AU2020242520B2 (es)
BR (1) BR112021018100A2 (es)
CA (1) CA3133736A1 (es)
CO (1) CO2021013127A2 (es)
CU (1) CU24712B1 (es)
EA (1) EA202192447A1 (es)
MX (1) MX2021011120A (es)
MY (1) MY206651A (es)
SG (1) SG11202109574QA (es)
TW (1) TW202102667A (es)
WO (1) WO2020187340A2 (es)
ZA (1) ZA202107758B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3746095A4 (en) 2018-02-01 2021-04-21 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
CN111918661A (zh) 2018-02-21 2020-11-10 得克萨斯大学体系董事会 用于活化和扩增自然杀伤细胞的方法及其用途
EP4143300A1 (en) 2020-04-28 2023-03-08 Lyell Immunopharma, Inc. Methods for culturing cells
TW202406932A (zh) 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
WO2023004004A1 (en) * 2021-07-23 2023-01-26 Merck Sharp & Dohme Llc Il-2 muteins for treating cancer or infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE526395T1 (de) * 2005-08-08 2011-10-15 San Raffaele Centro Fond Verwendung von il-7 und il-15 zur genetischen modifizierung von gedächtnis-t-lymphozyten
EP2207875A1 (en) * 2007-10-24 2010-07-21 Anne Letsch Antigen-specific t-cell preparations from bone marrow
CU23923B1 (es) 2010-11-12 2013-07-31 Ct De Inmunología Molecular Polipéptidos derivados de la il-2 con actividad agonista
CN109071679B (zh) * 2016-02-05 2023-07-28 华盛顿大学 用于靶向的细胞因子递送的组合物和方法

Also Published As

Publication number Publication date
CA3133736A1 (en) 2020-09-24
WO2020187340A2 (es) 2020-09-24
MX2021011120A (es) 2022-01-18
CN113785048A (zh) 2021-12-10
CO2021013127A2 (es) 2022-03-18
TW202102667A (zh) 2021-01-16
ZA202107758B (en) 2022-12-21
MY206651A (en) 2024-12-30
EA202192447A1 (ru) 2021-12-07
CU20190021A7 (es) 2020-10-20
JP7572371B2 (ja) 2024-10-23
AU2020242520B2 (en) 2024-04-04
US20220152107A1 (en) 2022-05-19
WO2020187340A3 (es) 2021-04-15
SG11202109574QA (en) 2021-10-28
KR20220012224A (ko) 2022-02-03
BR112021018100A2 (pt) 2022-02-08
EP3940063A2 (en) 2022-01-19
AU2020242520A1 (en) 2021-11-11
CN113785048B (zh) 2024-09-24
AR118369A1 (es) 2021-09-29
JP2022524882A (ja) 2022-05-10

Similar Documents

Publication Publication Date Title
CU24712B1 (es) Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
CL2018002763A1 (es) Moléculas de unión a bcma y métodos de uso de las mismas.
MX2021001837A (es) Constructos del receptor de celulas t y usos de los mismos.
MX2021003765A (es) Proteínas il-12 de fusión a fc heterodimérico.
ZA202105394B (en) Antibodies against il-7r alpha subunit and uses thereof
AR118510A1 (es) Métodos para la producción de células car-nk y sus usos
MX2019002998A (es) Celulas t con resistencia incrementada a la inmunosupresion.
CL2018001427A1 (es) Composiciones de anticuerpo injertado con citoquina y métodos para su uso en inmunorregulación.
WO2019222275A3 (en) Compositions and methods for tcr reprogramming using inducible fusion proteins
EA202092243A1 (ru) Способы усиления персистенции адоптивно инфузированных т-клеток
MX2024002838A (es) Metodos para tratar trastornos usando inhibidores de csf1r.
CU24437B1 (es) Anticuerpos agonistas de anti-gitr y composiciones de los mismos
CL2017002244A1 (es) Anticuerpos biespecíficos específicos para fap y dr5, anticuerpos específicos para dr5 y métodos de utilización. (divisional de solicitud 2829-2015).
EA202090931A2 (ru) Композиции и способы перепрограммирования tcr с помощью гибридных белков
EP3589303A4 (en) Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy
Stamatopoulos et al. Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
MX2020009371A (es) Composiciones y métodos para la reprogramación de tcr mediante el uso de proteínas de fusión.
AR103726A1 (es) Cristales de anticuerpos monoclonales anti-pd-1 humanos
MX393707B (es) Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos.
CY1124672T1 (el) Μεθοδοι αποθηκευσης τραπεζων κυτταρων εξαιρετικα υψηλης πυκνοτητας
MX2016003103A (es) Combinacion de anticuerpos anti-gen 3 de la activacion del linfoncito (lag-3) y anticuerpos anti-muerte celular programada 1 (pd-1) para tratar tumores.
MX2020011788A (es) Acoplador trifuncional de antigeno de celulas t y metodos y usos del mismo.
PA8847001A1 (es) Anticuerpos humanos de alta afinidad para el receptor il-4-humano
Rea et al. Low natural killer (NK) cell counts and functionality are associated with molecular relapse after imatinib discontinuation in patients (pts) with chronic phase (CP)-chronic myeloid leukemia (CML) with undetectable BCR-ABL transcripts for at least 2 years: preliminary results from immunostim, On Behalf Of STIM Investigators
MX2019006286A (es) Metodos para determinar la dosificacion en la terapia celular.