CU20090112A6 - Compuestos macrocíclicos como inhibidores de la replicación viral - Google Patents
Compuestos macrocíclicos como inhibidores de la replicación viralInfo
- Publication number
- CU20090112A6 CU20090112A6 CU20090112A CU20090112A CU20090112A6 CU 20090112 A6 CU20090112 A6 CU 20090112A6 CU 20090112 A CU20090112 A CU 20090112A CU 20090112 A CU20090112 A CU 20090112A CU 20090112 A6 CU20090112 A6 CU 20090112A6
- Authority
- CU
- Cuba
- Prior art keywords
- methods
- inhibitors
- viral replication
- macrocyclic compounds
- compound
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002678 macrocyclic compounds Chemical class 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 206010057199 Flaviviral infections Diseases 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55816104P | 2004-03-30 | 2004-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20090112A6 true CU20090112A6 (es) | 2012-03-15 |
Family
ID=37955155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20090112A CU20090112A6 (es) | 2004-03-30 | 2009-06-24 | Compuestos macrocíclicos como inhibidores de la replicación viral |
Country Status (5)
| Country | Link |
|---|---|
| CN (1) | CN1938311A (uk) |
| CU (1) | CU20090112A6 (uk) |
| TN (1) | TNSN06308A1 (uk) |
| UA (1) | UA91677C2 (uk) |
| ZA (1) | ZA200608798B (uk) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100167302A1 (en) * | 2007-09-10 | 2010-07-01 | Novartis Ag | Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy |
| CA2952692C (en) | 2008-09-22 | 2020-04-28 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds |
| PT3372605T (pt) | 2008-10-22 | 2021-12-09 | Array Biopharma Inc | Compostos de pirazolo[1,5-a]pirimidina substituídos como inibidores de quinase trk |
| KR101713066B1 (ko) * | 2009-02-27 | 2017-03-07 | 얀센 파마슈티칼스 인코포레이티드 | Ｈｃｖ 마크로사이클릭 저해제의 무정형 염 |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| CA2774387A1 (en) * | 2009-09-28 | 2011-03-31 | F. Hoffmann-La Roche Ltd | Novel macrocyclic inhibitors of hepatitis c virus replication |
| CN102140100B (zh) * | 2010-01-27 | 2014-06-11 | 爱博新药研发(上海)有限公司 | 高效抑制丙型肝炎病毒的多环化合物及其制备方法和用途 |
| SMT201900203T1 (it) * | 2010-05-20 | 2019-05-10 | Array Biopharma Inc | Composti macrociclici come inibitori di trk chinasi |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| CA2967951C (en) | 2014-11-16 | 2023-11-07 | Array Biopharma, Inc. | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| CN107043405B (zh) * | 2016-02-05 | 2021-11-19 | 爱博新药研发(上海)有限公司 | 多环杂环化合物的晶型、其制备方法、应用及组合物 |
| PH12018502124B1 (en) | 2016-04-04 | 2024-04-12 | Loxo Oncology Inc | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| PT3458456T (pt) | 2016-05-18 | 2020-12-07 | Array Biopharma Inc | Preparação de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidino-1-carboxamida |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
-
2005
- 2005-03-29 UA UAA200611368A patent/UA91677C2/uk unknown
- 2005-03-29 CN CN 200580010503 patent/CN1938311A/zh active Pending
-
2006
- 2006-09-27 TN TNP2006000308A patent/TNSN06308A1/en unknown
- 2006-10-23 ZA ZA200608798A patent/ZA200608798B/xx unknown
-
2009
- 2009-06-24 CU CU20090112A patent/CU20090112A6/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1938311A (zh) | 2007-03-28 |
| ZA200608798B (en) | 2008-06-25 |
| TNSN06308A1 (en) | 2007-12-03 |
| UA91677C2 (uk) | 2010-08-25 |
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