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CU20090112A6 - MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION - Google Patents

MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

Info

Publication number
CU20090112A6
CU20090112A6 CU20090112A CU20090112A CU20090112A6 CU 20090112 A6 CU20090112 A6 CU 20090112A6 CU 20090112 A CU20090112 A CU 20090112A CU 20090112 A CU20090112 A CU 20090112A CU 20090112 A6 CU20090112 A6 CU 20090112A6
Authority
CU
Cuba
Prior art keywords
methods
inhibitors
viral replication
macrocyclic compounds
compound
Prior art date
Application number
CU20090112A
Other languages
Spanish (es)
Inventor
Yutong Jaing
Benjamin Woodard
George Andrew Doherty
Peter John Stengel
John Anthony Josey
Kevin Ronald Condroski
April Layne Kennedy
Steven Wade Andrews
Steven Mark Wenglowsky
Lawrence M Blatt
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of CU20090112A6 publication Critical patent/CU20090112A6/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En diversas realizaciones se proveen compuestos de las fórmulas generales I-XIX, así como composiciones, entre las que se incluyen composiciones farmacéuticas, que comprenden un compuestos de la invención. Las realizaciones proveen además métodos de tratamiento, que incluyen métodos de tratamiento de infecciones flavivirales, que incluyen la infección por el virus de hepatitis C y métodos de tratar la fibrosis hepática. Los métodos consisten en general en la administración a un individuo que lo necesita, una cantidad eficaz de un compuesto o composición de la invención.In various embodiments, compounds of the general formulas I-XIX are provided, as well as compositions, including pharmaceutical compositions, comprising a compound of the invention. The embodiments further provide treatment methods, which include methods of treating flaviviral infections, which include hepatitis C virus infection and methods of treating liver fibrosis. The methods generally consist of administering to an individual in need, an effective amount of a compound or composition of the invention.

CU20090112A 2004-03-30 2009-06-24 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION CU20090112A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30

Publications (1)

Publication Number Publication Date
CU20090112A6 true CU20090112A6 (en) 2012-03-15

Family

ID=37955155

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20090112A CU20090112A6 (en) 2004-03-30 2009-06-24 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

Country Status (5)

Country Link
CN (1) CN1938311A (en)
CU (1) CU20090112A6 (en)
TN (1) TNSN06308A1 (en)
UA (1) UA91677C2 (en)
ZA (1) ZA200608798B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100167302A1 (en) * 2007-09-10 2010-07-01 Novartis Ag Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy
RS53350B (en) 2008-09-22 2014-10-31 Array Biopharma, Inc. SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS
PT2725028T (en) 2008-10-22 2016-08-31 Array Biopharma Inc Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of trk kinase inhibitors
KR101868412B1 (en) 2009-02-27 2018-06-18 얀센 파마슈티칼스 인코포레이티드 Amorphous salt of a macrocyclic inhibitor of hcv
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
JP2013505951A (en) * 2009-09-28 2013-02-21 エフ．ホフマン−ラ ロシュ エルティーディー Novel macrocyclic inhibitor of hepatitis C virus replication
EP2528922B1 (en) * 2010-01-27 2017-08-02 AB Pharma Ltd Polyheterocyclic compounds as hcv inhibitors
WO2011146336A1 (en) 2010-05-20 2011-11-24 Array Biopharma Inc. Macrocyclic compounds as trk kinase inhibitors
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
ES2941630T3 (en) 2014-11-16 2023-05-24 Array Biopharma Inc Hydrogen sulfate crystalline form of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3- yl)-3-hydroxypyrrolidine-1-carboxamide
TN2019000271A1 (en) 2015-10-26 2021-01-07 Univ Colorado Regents Point mutations in trk inhibitor-resistant cancer and methods relating to the same
CN107043405B (en) * 2016-02-05 2021-11-19 爱博新药研发(上海)有限公司 Crystal form of polycyclic heterocyclic compound, preparation method, application and composition thereof
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
MX386416B (en) 2016-04-04 2025-03-18 Loxo Oncology Inc Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
PE20190437A1 (en) 2016-05-18 2019-03-27 Loxo Oncology Inc PROCESSES FOR THE PREPARATION OF (S) -N- (5 - ((R) -2- (2,5-DIFLUOROPHENYL) PYRROLIDIN-1-IL) -PIRAZOLO [1,5-A] PYRIMIDIN-3-IL) - 3-HYDROXYPYRROLIDIN-1-CARBOXAMIDE AND SALTS THEREOF
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors

Also Published As

Publication number Publication date
TNSN06308A1 (en) 2007-12-03
CN1938311A (en) 2007-03-28
UA91677C2 (en) 2010-08-25
ZA200608798B (en) 2008-06-25

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