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CS231957B2 - Manufacturing process of heterocyclic compounds - Google Patents

Manufacturing process of heterocyclic compounds Download PDF

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Publication number
CS231957B2
CS231957B2 CS757510A CS751075A CS231957B2 CS 231957 B2 CS231957 B2 CS 231957B2 CS 757510 A CS757510 A CS 757510A CS 751075 A CS751075 A CS 751075A CS 231957 B2 CS231957 B2 CS 231957B2
Authority
CS
Czechoslovakia
Prior art keywords
chloro
naphthyridin
item
methylene chloride
piperazinyl
Prior art date
Application number
CS757510A
Other languages
Czech (cs)
English (en)
Other versions
CS751075A2 (en
Inventor
Claude Cotrel
Cornel Crisan
Claude Jeanmart
Mayer N Messer
Original Assignee
Rhone Poulenc Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7436963A external-priority patent/FR2313060A1/fr
Priority claimed from FR7527162A external-priority patent/FR2322602A1/fr
Priority claimed from FR7527161A external-priority patent/FR2322601A1/fr
Priority claimed from FR7527160A external-priority patent/FR2322600A1/fr
Application filed by Rhone Poulenc Ind filed Critical Rhone Poulenc Ind
Priority to CS775983A priority Critical patent/CS231958B2/cs
Priority to CS775984A priority patent/CS231959B2/cs
Publication of CS751075A2 publication Critical patent/CS751075A2/cs
Publication of CS231957B2 publication Critical patent/CS231957B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS757510A 1974-11-07 1975-11-07 Manufacturing process of heterocyclic compounds CS231957B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS775983A CS231958B2 (en) 1974-11-07 1977-09-14 Manufacturing process of new heteroclic compoundes
CS775984A CS231959B2 (cs) 1975-11-07 1977-09-14 Způsob výroby nových heterocyklických sloučenin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR7436963A FR2313060A1 (fr) 1974-11-07 1974-11-07 Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent
FR7527162A FR2322602A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de l'oxathiinno- et du dithiinnopyrrole, leur preparation et les compositions qui les contiennent
FR7527161A FR2322601A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent
FR7527160A FR2322600A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de la pyrrolo (3,4-b) pyrazine, leur preparation et les compositions qui les contiennent

Publications (2)

Publication Number Publication Date
CS751075A2 CS751075A2 (en) 1984-01-16
CS231957B2 true CS231957B2 (en) 1985-01-16

Family

ID=27446274

Family Applications (2)

Application Number Title Priority Date Filing Date
CS757510A CS231957B2 (en) 1974-11-07 1975-11-07 Manufacturing process of heterocyclic compounds
CS775983A CS231958B2 (en) 1974-11-07 1977-09-14 Manufacturing process of new heteroclic compoundes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS775983A CS231958B2 (en) 1974-11-07 1977-09-14 Manufacturing process of new heteroclic compoundes

Country Status (27)

Country Link
US (1) US4220646A (fr)
JP (2) JPS5422996B2 (fr)
AR (2) AR208414A1 (fr)
AT (2) AT343123B (fr)
AU (1) AU503200B2 (fr)
BE (1) BE835325A (fr)
CA (1) CA1057755A (fr)
CH (1) CH609057A5 (fr)
CS (2) CS231957B2 (fr)
CY (1) CY1045A (fr)
DD (1) DD122684A5 (fr)
DE (1) DE2550111C2 (fr)
DK (1) DK141098B (fr)
FI (1) FI60707C (fr)
GB (1) GB1468497A (fr)
HK (1) HK19380A (fr)
HU (1) HU173108B (fr)
IE (1) IE41928B1 (fr)
IL (1) IL48423A (fr)
LU (1) LU73738A1 (fr)
NL (1) NL177405C (fr)
NO (1) NO143576C (fr)
OA (1) OA05162A (fr)
PL (1) PL101248B1 (fr)
SE (1) SE407063B (fr)
SU (2) SU673173A3 (fr)
YU (2) YU39583B (fr)

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FR2371198A2 (fr) * 1976-11-22 1978-06-16 Rhone Poulenc Ind Nouveaux derives du dithiepinno (1,4)(2,3-c) pyrrole, leur preparation et les compositions qui les contiennent
US4533751A (en) * 1981-10-09 1985-08-06 Scm Corporation Preparation of 1,3-dienamines from myrcene and substituted myrcene
FR2525606A1 (fr) * 1982-04-22 1983-10-28 Rhone Poulenc Sante Nouveaux derives du dithiino (1,4) (2,3-c) pyrrole, leur preparation et les medicaments qui les contiennent
FR2607504B1 (fr) * 1986-12-02 1989-01-27 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2607506B1 (fr) * 1986-12-02 1989-01-06 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2671800B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
HU214331B (hu) * 1992-06-17 1998-03-02 Gyógyszerkutató Intézet Kft. Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
TW279864B (fr) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
US5922820A (en) * 1993-06-04 1999-07-13 Henkel Corporation Polymerizable compounds
AU6956394A (en) * 1993-06-04 1995-01-03 Henkel Corporation Polymerizable compounds
US5565567A (en) * 1993-06-04 1996-10-15 Henkel Corporation. Polymerizable N,N'-substituted piperazine acrylamide compounds
CN1160398A (zh) 1994-09-23 1997-09-24 阿瑞斯药物公司 治疗肥大细胞炎性疾病的组合物和方法
US5663357A (en) * 1995-11-22 1997-09-02 Allergan Substituted heteroarylamides having retinoid-like biological activity
US5756742A (en) * 1995-12-22 1998-05-26 Henkel Corporation Polymerizable compounds
US6339086B1 (en) * 1999-05-14 2002-01-15 Swpracor, Inc. Methods of making and using N-desmethylzopiclone
JP4196678B2 (ja) * 2001-04-26 2008-12-17 味の素株式会社 複素環化合物
ES2256723T3 (es) 2002-03-29 2006-07-16 Indevus Pharmaceuticals, Inc. Metodos de preparacion de la 2-(7-cloro-1,8-naftiridina-2-il)-3-(5-metil-2-oxo-hexil)-1-isoindolinona.
WO2004037212A2 (fr) * 2002-10-24 2004-05-06 Sepracor, Inc. Compositions contenant des derives du zopiclone, et leurs procedes de preparation et d'utilisation
AR042194A1 (es) * 2002-11-22 2005-06-15 Merck & Co Inc Metodo para preparar inhibidores de fosfodiesterasa - 4
UA79518C2 (en) * 2002-11-22 2007-06-25 Merck & Co Inc Process for preparation of phosphodiesterase-4 inhibitors
US6909002B2 (en) * 2002-11-22 2005-06-21 Merck & Co., Inc. Method of preparing inhibitors of phosphodiesterase-4
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
WO2005105061A2 (fr) * 2004-04-14 2005-11-10 Indevus Pharmaceuticals, Inc. Patch transdermique
WO2007006003A2 (fr) 2005-07-06 2007-01-11 Sepracor Inc. Combinaisons d'eszopiclone et de trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphtalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphtalenamine, et methodes de traitement de la menopause et des troubles de l'humeur, de l'anxiete et troubles cognitifs
CN101257898A (zh) * 2005-07-06 2008-09-03 塞普拉科公司 艾司佐匹克隆与o-去甲基文拉法辛的组合以及治疗绝经期和心境障碍、焦虑症和认知障碍的方法
EP2258359A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline
EP2275096A3 (fr) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenese par modulation des recepteurs muscariniques
EP1940389A2 (fr) 2005-10-21 2008-07-09 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2382975A3 (fr) 2006-05-09 2012-02-29 Braincells, Inc. Neurogénèse par modulation d'angiotensine
CA2651862A1 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenese induite par le recepteur 5ht
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20080305171A1 (en) * 2007-06-07 2008-12-11 Kristin Anne Arnold Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
CN100569775C (zh) * 2007-12-19 2009-12-16 齐鲁天和惠世制药有限公司 佐匹克隆的晶型转换的方法
EP3632417A1 (fr) 2009-01-30 2020-04-08 Sunovion Pharmaceuticals Inc. Comprimés de 6-(5-chloro-2-pyridyl)-5-[(4-méthyl-1-pipérazinyl)carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrolo [3,4-b] pyrazine enrobés
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
JP6984656B2 (ja) * 2017-05-25 2021-12-22 信越化学工業株式会社 フルオロポリエーテル基含有ポリマー変性有機ケイ素化合物、表面処理剤及び物品
CN108129476A (zh) * 2017-11-27 2018-06-08 华中农业大学 一种杂环内酰胺衍生物及其用于作物病原菌杀菌剂的用途
WO2026004941A1 (fr) * 2024-06-27 2026-01-02 日本臓器製薬株式会社 Dérivé d'alcyne

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1312427A (fr) * 1961-04-12 1962-12-21 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
FR2101081B1 (fr) * 1970-08-19 1974-01-11 Rhone Poulenc Sa
BE790408A (fr) * 1971-10-22 1973-04-20 Rhone Poulenc Sa Nouveaux derives de la pyrrolo (3,4-b) pyridine, leur preparation et les compositions medicinales qui les
OA04285A (fr) * 1972-01-07 1979-12-31 Rhone Poulenc Sa Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
BE793851A (fr) * 1972-01-10 1973-07-10 Rhone Poulenc Sa Nouveaux derives de l'isoindoline, leur preparation et les compositions medicinales qui les contiennent
AR207555A1 (es) * 1972-12-04 1976-10-15 Procedimiento para preparar aril-6-piperazinocarboniloxi-5 oxo-7 tetrahidro-2,3,6,7 ditiino(1,4)(2,3-c)pirroles
OA04700A (fr) * 1973-05-15 1980-07-31 Rhone Poulenc Sa Nouveaux dérivés de la naphtyridine et leur procédé de préparation.

Also Published As

Publication number Publication date
PL101248B1 (pl) 1978-12-30
DE2550111A1 (de) 1976-05-13
GB1468497A (en) 1977-03-30
NO143576B (no) 1980-12-01
OA05162A (fr) 1981-01-31
ATA401977A (de) 1977-10-15
HK19380A (en) 1980-04-18
CA1057755A (fr) 1979-07-03
SU604496A3 (ru) 1978-04-25
CH609057A5 (fr) 1979-02-15
JPS5422996B2 (fr) 1979-08-10
SU673173A3 (ru) 1979-07-05
FI753127A7 (fr) 1976-05-08
NL7512732A (nl) 1976-05-11
SE407063B (sv) 1979-03-12
CS231958B2 (en) 1985-01-16
BE835325A (fr) 1976-05-06
AR208800A1 (es) 1977-02-28
AU503200B2 (en) 1979-08-30
SE7512477L (sv) 1976-05-10
NO753713L (fr) 1976-05-10
NO143576C (no) 1981-03-11
US4220646A (en) 1980-09-02
AU8633175A (en) 1977-05-12
DK499275A (fr) 1976-05-08
YU40087B (en) 1985-06-30
JPS558508B2 (fr) 1980-03-04
ATA848675A (de) 1977-09-15
HU173108B (hu) 1979-02-28
IE41928B1 (en) 1980-04-23
YU192182A (en) 1983-01-21
NL177405C (nl) 1985-09-16
IL48423A (en) 1979-03-12
YU281575A (en) 1983-01-21
IL48423A0 (en) 1976-01-30
AT343666B (de) 1978-06-12
CS598377A2 (en) 1984-01-16
AT343123B (de) 1978-05-10
DK141098B (da) 1980-01-14
CS751075A2 (en) 1984-01-16
JPS5170776A (fr) 1976-06-18
JPS5498790A (en) 1979-08-03
NL177405B (nl) 1985-04-16
CY1045A (en) 1980-08-01
YU39583B (en) 1985-03-20
AR208414A1 (es) 1976-12-27
LU73738A1 (fr) 1976-09-06
DE2550111C2 (de) 1983-09-15
DD122684A5 (fr) 1976-10-20
FI60707C (fi) 1982-03-10
IE41928L (en) 1976-05-07
DK141098C (fr) 1980-07-07
FI60707B (fi) 1981-11-30

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