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CR8876A - 1,1,2,2-TETRA (HETERO) ARILETANOS 1,1,2-TRI (HETERO) -ARIL-2-HETEROCICLOETANOS AS INHIBITORS OF POTASSIUM CHANNELS - Google Patents

1,1,2,2-TETRA (HETERO) ARILETANOS 1,1,2-TRI (HETERO) -ARIL-2-HETEROCICLOETANOS AS INHIBITORS OF POTASSIUM CHANNELS

Info

Publication number
CR8876A
CR8876A CR8876A CR8876A CR8876A CR 8876 A CR8876 A CR 8876A CR 8876 A CR8876 A CR 8876A CR 8876 A CR8876 A CR 8876A CR 8876 A CR8876 A CR 8876A
Authority
CR
Costa Rica
Prior art keywords
hetero
inhibitors
heterocicloetanos
ariletanos
aril
Prior art date
Application number
CR8876A
Other languages
Spanish (es)
Inventor
T Bilodeau Mark
Wu Zhicai
Hartnett John
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CR8876A publication Critical patent/CR8876A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invencion se refiere a compuestos que tienen la estructura que se muestra, utiles como inhibidores del canal de potasio para tratar arritmias cardiacas y afecciones similares.The present invention relates to compounds having the structure shown, useful as potassium channel inhibitors for treating cardiac arrhythmias and similar conditions.

CR8876A 2004-07-29 2007-01-25 1,1,2,2-TETRA (HETERO) ARILETANOS 1,1,2-TRI (HETERO) -ARIL-2-HETEROCICLOETANOS AS INHIBITORS OF POTASSIUM CHANNELS CR8876A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59218104P 2004-07-29 2004-07-29

Publications (1)

Publication Number Publication Date
CR8876A true CR8876A (en) 2007-08-28

Family

ID=35613661

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8876A CR8876A (en) 2004-07-29 2007-01-25 1,1,2,2-TETRA (HETERO) ARILETANOS 1,1,2-TRI (HETERO) -ARIL-2-HETEROCICLOETANOS AS INHIBITORS OF POTASSIUM CHANNELS

Country Status (15)

Country Link
KR (1) KR20070043985A (en)
AR (1) AR049847A1 (en)
BR (1) BRPI0513793A (en)
CR (1) CR8876A (en)
EC (1) ECSP077208A (en)
IL (1) IL180846A0 (en)
MA (1) MA28980B1 (en)
MX (1) MX2007001188A (en)
NO (1) NO20071107L (en)
PE (1) PE20060382A1 (en)
RU (1) RU2344134C2 (en)
TW (1) TW200607493A (en)
UA (1) UA88018C2 (en)
WO (1) WO2006028590A1 (en)
ZA (1) ZA200700477B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102427806B (en) * 2009-03-18 2015-11-25 麦迪库瑞国际公司 Transdermal pharmaceutical formulation and administration of tirofiban
NZ703632A (en) 2012-06-11 2016-01-29 Bristol Myers Squibb Co Phosphoramidic acid prodrugs of 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2140865B2 (en) * 1971-08-14 1979-10-11 Bayer Ag, 5090 Leverkusen 1-imidazolyl-methanephosphonic acid ester, process for their preparation and medicaments containing them
DE19951701A1 (en) * 1999-10-27 2001-05-03 Aventis Pharma Gmbh Use of 2-imidazolyl-substituted carbinols for the manufacture of a medicament for the treatment or prophylaxis of diseases caused by ischemic conditions
ATE400551T1 (en) * 2002-01-04 2008-07-15 Neurosearch As POTASSIUM CHANNEL MODULATORS

Also Published As

Publication number Publication date
MX2007001188A (en) 2007-03-21
BRPI0513793A (en) 2008-05-13
PE20060382A1 (en) 2006-05-15
ZA200700477B (en) 2009-08-26
RU2344134C2 (en) 2009-01-20
MA28980B1 (en) 2007-11-01
RU2007107408A (en) 2008-09-10
IL180846A0 (en) 2007-06-03
UA88018C2 (en) 2009-09-10
ECSP077208A (en) 2007-02-28
WO2006028590A1 (en) 2006-03-16
KR20070043985A (en) 2007-04-26
TW200607493A (en) 2006-03-01
NO20071107L (en) 2007-04-19
AR049847A1 (en) 2006-09-06

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)