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CR7657A - Moduladores selectivos de receptores de estrogenos que contienen un grupo de fenilsulfonilo - Google Patents

Moduladores selectivos de receptores de estrogenos que contienen un grupo de fenilsulfonilo

Info

Publication number
CR7657A
CR7657A CR7657A CR7657A CR7657A CR 7657 A CR7657 A CR 7657A CR 7657 A CR7657 A CR 7657A CR 7657 A CR7657 A CR 7657A CR 7657 A CR7657 A CR 7657A
Authority
CR
Costa Rica
Prior art keywords
sulphonile
strogen
phenyl
group
receptors containing
Prior art date
Application number
CR7657A
Other languages
English (en)
Inventor
Dean Dally Robert
Alan Dodge Jeffrey
Alan Jones Scott
Alan Shephered Timothy
Brendan Wallace Owen
Chiu Fong Kin
Wilson Hummel Conrad
Sal Lewis George
Allan Frank Scott
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR7657A publication Critical patent/CR7657A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion se refiere a un modulador selectivo del receptor de estrogenos de formula I o a una sal de adicion de acido farmaceutica del mismo, por ejemplo, para el tratamiento de la endometriosis y/o el leiomioma/leiomiomata uterino.
CR7657A 2002-07-22 2005-01-18 Moduladores selectivos de receptores de estrogenos que contienen un grupo de fenilsulfonilo CR7657A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39786902P 2002-07-22 2002-07-22
US45023303P 2003-02-25 2003-02-25

Publications (1)

Publication Number Publication Date
CR7657A true CR7657A (es) 2005-07-13

Family

ID=30773044

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7657A CR7657A (es) 2002-07-22 2005-01-18 Moduladores selectivos de receptores de estrogenos que contienen un grupo de fenilsulfonilo

Country Status (24)

Country Link
US (2) US7399867B2 (es)
EP (1) EP1530470B9 (es)
JP (2) JP4656939B2 (es)
CN (1) CN1668303B (es)
AT (1) ATE433322T1 (es)
AU (1) AU2003253129B2 (es)
BR (1) BR0312675A (es)
CA (1) CA2490580C (es)
CO (1) CO5680445A2 (es)
CR (1) CR7657A (es)
DE (1) DE60327931D1 (es)
EA (1) EA008024B1 (es)
EC (1) ECSP055549A (es)
ES (1) ES2326593T3 (es)
HR (1) HRP20041233A2 (es)
IL (1) IL165745A0 (es)
MX (1) MXPA05000898A (es)
MY (1) MY141879A (es)
NO (1) NO20050832L (es)
NZ (1) NZ537138A (es)
PE (1) PE20040678A1 (es)
PL (1) PL374845A1 (es)
TW (1) TWI314860B (es)
WO (1) WO2004009086A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60327931D1 (de) * 2002-07-22 2009-07-23 Lilly Co Eli Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten
PL377494A1 (pl) * 2003-02-25 2006-02-06 Eli Lilly And Company Krystaliczny, niesolwatowany chlorowodorek 1-(4-(2-pipe-rydynyloetoksy) fenoksy)-2-(4-metanosulfonylofenylo)-6- hydroksynaftalenu
HRP20050675A2 (en) * 2003-02-25 2005-10-31 Eli Lilly And Company Crystalline non-solavated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride
CN1910167B (zh) * 2004-01-22 2011-08-10 伊莱利利公司 用于治疗血管舒缩症状的选择性雌激素受体调节剂
WO2005073206A1 (en) * 2004-01-22 2005-08-11 Eli Lilly And Company Selective estrogen receptor modulators
US20090023917A1 (en) 2004-01-22 2009-01-22 Eli Lilly And Company Selective Estrogen Receptor Modulators for the Treatment of Vasomotor Symptoms
EP1713770A1 (en) * 2004-01-29 2006-10-25 Eli Lilly And Company Selective estrogen receptor modulators
KR20070026841A (ko) * 2004-06-22 2007-03-08 스미스클라인 비참 코포레이션 화합물
CA2617146A1 (en) * 2005-07-29 2007-02-08 Eli Lilly And Company Crystalline non-solvated methanesulfonic acid salt of 1-(4-(2-piperidinylethoxy)phenoxy)-2-(3-hydroxyphenyl)-6-hydroxynaphthalene
EA020742B1 (ru) * 2008-09-29 2015-01-30 Эли Лилли Энд Компани Селективный модулятор рецепторов эстрогена
DE102008057230A1 (de) 2008-11-11 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin
EP2406230A1 (en) 2009-03-11 2012-01-18 Pfizer Inc. Substituted indazole amides and their use as glucokinase activators
KR20170127044A (ko) 2010-06-16 2017-11-20 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
JP6292744B2 (ja) * 2012-09-19 2018-03-14 富士カプセル株式会社 医薬品組成物
ES2671516T3 (es) 2013-02-19 2018-06-06 Novartis Ag Derivados de benzotiofeno y composiciones de los mismos como degradantes selectivos de los receptores de estrógeno
ES2953140T3 (es) 2019-03-08 2023-11-08 Syngenta Crop Protection Ag Compuestos de azol-amida activos de manera plaguicida
JP2022525967A (ja) 2019-03-20 2022-05-20 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物活性アゾールアミド化合物
EP3941914A1 (en) 2019-03-22 2022-01-26 Syngenta Crop Protection AG N-[1-(5-bromo-2-pyrimidin-2-yl-1,2,4-triazol-3-yl)ethyl]-2-cyclopropyl-6-(trifluoromethyl)pyridine-4-carboxamide derivatives and related compounds as insecticides
UY38623A (es) 2019-03-29 2020-10-30 Syngenta Crop Protection Ag Compuestos de diazina-amida activos como pesticidas
MX2021012162A (es) 2019-04-05 2021-11-03 Syngenta Crop Protection Ag Compuestos de diazina-amida activos como pesticidas.
JP2022545266A (ja) 2019-08-23 2022-10-26 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物的に活性なピラジン-アミド化合物
CN110526881B (zh) * 2019-08-27 2020-09-22 河南省锐达医药科技有限公司 一种萘胺类化合物及其生物学可接受的盐,其制备方法和应用
BR112022017093A2 (pt) 2020-02-27 2023-02-14 Syngenta Crop Protection Ag Compostos de diazina-bisamida ativos em termos pesticidas
WO2022237904A1 (zh) * 2021-05-14 2022-11-17 江苏亚虹医药科技股份有限公司 一种含萘环的化合物、含其的药物组合物及其应用
US20240287047A1 (en) 2021-06-09 2024-08-29 Syngenta Crop Protection Ag Pesticidally active diazine-amide compounds
WO2023283315A1 (en) * 2021-07-07 2023-01-12 South Dakota Board Of Regents Compositions and methods for treatment of cervical and ovarian cancer
EP4577532A1 (en) 2022-08-25 2025-07-02 Sanofi Novel substituted benzothiophene-6-carboxylic acid derivatives, processes for their preparation and therapeutic uses thereof

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AU665690B2 (en) 1992-05-08 1996-01-11 Otsuka Pharmaceutical Factory, Inc. Indole derivative
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US5552412A (en) 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
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JP3989569B2 (ja) 1995-02-28 2007-10-10 イーライ リリー アンド カンパニー ベンゾチオフェン化合物、中間体、組成物および方法
US5599822A (en) 1995-06-06 1997-02-04 Eli Lilly And Company Methods for minimizing bone loss
DE69634045T2 (de) * 1995-10-31 2005-05-19 Eli Lilly And Co., Indianapolis Antithrombotische diamine
JP2000505455A (ja) * 1996-02-22 2000-05-09 イーライ・リリー・アンド・カンパニー ベンゾチオフエン類、それらを含む製剤、および方法
ATE206701T1 (de) 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
CA2213814A1 (en) 1996-08-29 1998-02-28 Henry Uhlman Bryant Naphthalene compounds, intermediates, formulations, and methods
CA2214070C (en) 1996-08-29 2006-03-14 Eli Lilly And Company Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods
ID19392A (id) 1996-08-29 1998-07-09 Lilly Co Eli Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan
CA2213810C (en) 1996-08-29 2006-06-06 Lewis Dale Pennington Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods
CA2217810A1 (en) * 1996-10-10 1998-04-10 Eli Lilly And Company 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods
JPH10204082A (ja) 1996-10-25 1998-08-04 Eli Lilly & Co 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ[b]チオフェン化合物
DE60327931D1 (de) * 2002-07-22 2009-07-23 Lilly Co Eli Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten

Also Published As

Publication number Publication date
EP1530470B1 (en) 2009-06-10
CO5680445A2 (es) 2006-09-29
CA2490580A1 (en) 2004-01-29
AU2003253129A1 (en) 2004-02-09
IL165745A0 (en) 2006-01-15
NZ537138A (en) 2007-11-30
US7399867B2 (en) 2008-07-15
EP1530470B9 (en) 2010-04-07
JP5220800B2 (ja) 2013-06-26
JP2005538089A (ja) 2005-12-15
TW200414901A (en) 2004-08-16
BR0312675A (pt) 2005-05-03
HRP20041233A2 (en) 2005-02-28
TWI314860B (en) 2009-09-21
JP4656939B2 (ja) 2011-03-23
AU2003253129B2 (en) 2008-12-11
WO2004009086A1 (en) 2004-01-29
PL374845A1 (en) 2005-11-14
NO20050832L (no) 2005-02-16
MXPA05000898A (es) 2005-05-16
ATE433322T1 (de) 2009-06-15
CN1668303B (zh) 2010-10-27
DE60327931D1 (de) 2009-07-23
US20080214612A1 (en) 2008-09-04
PE20040678A1 (es) 2004-10-06
CN1668303A (zh) 2005-09-14
EP1530470A1 (en) 2005-05-18
EA008024B1 (ru) 2007-02-27
US20060183736A1 (en) 2006-08-17
ES2326593T3 (es) 2009-10-15
ECSP055549A (es) 2005-03-10
MY141879A (en) 2010-07-16
HK1078003A1 (en) 2006-03-03
US7585977B2 (en) 2009-09-08
EA200500248A1 (ru) 2005-06-30
JP2010195820A (ja) 2010-09-09
CA2490580C (en) 2012-12-11

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