CR7011A - Proceso para hacer maleato de amlodipine - Google Patents
Proceso para hacer maleato de amlodipineInfo
- Publication number
- CR7011A CR7011A CR7011A CR7011A CR7011A CR 7011 A CR7011 A CR 7011A CR 7011 A CR7011 A CR 7011A CR 7011 A CR7011 A CR 7011A CR 7011 A CR7011 A CR 7011A
- Authority
- CR
- Costa Rica
- Prior art keywords
- amlodipine maleate
- make
- make amlodipine
- amlodipine
- maleate
- Prior art date
Links
- 229960000528 amlodipine Drugs 0.000 title abstract 3
- TZNOWAJJWCGILX-BTJKTKAUSA-N (z)-but-2-enedioic acid;3-o-ethyl 5-o-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound OC(=O)\C=C/C(O)=O.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl TZNOWAJJWCGILX-BTJKTKAUSA-N 0.000 title abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/90—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having more than three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN PROCESO QUE COMPRENDE AMLODIPINA RWACTIVA O UNA SAL DE ADICION DE LA MISMA CON ACIDO MALEICO BAJO UN MEDIO ACIDO PARA FORMAR UN PRODUCTO DE MALEATO DE AMLODIPINA.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25860200P | 2000-12-29 | 2000-12-29 | |
| US80934901A | 2001-03-16 | 2001-03-16 | |
| BE2001/0712A BE1014455A6 (nl) | 2000-12-29 | 2001-11-05 | Aspartaatderivaat van amlodipine. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR7011A true CR7011A (es) | 2004-03-10 |
Family
ID=29740328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR7011A CR7011A (es) | 2000-12-29 | 2003-06-26 | Proceso para hacer maleato de amlodipine |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6479525B2 (es) |
| EP (1) | EP1309558A1 (es) |
| BE (1) | BE1014455A6 (es) |
| BR (1) | BR0116553A (es) |
| CA (2) | CA2433191A1 (es) |
| CR (1) | CR7011A (es) |
| DE (1) | DE20116170U1 (es) |
| GB (1) | GB2372036B (es) |
| GR (1) | GR1004124B (es) |
| HU (1) | HUP0105456A3 (es) |
| IE (1) | IES20011105A2 (es) |
| MX (1) | MXPA03005886A (es) |
| WO (1) | WO2002053540A1 (es) |
| ZA (1) | ZA200110470B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2239432C2 (ru) * | 2000-04-11 | 2004-11-10 | Санкио Компани Лимитед, Убе Индастриз, Лтд. | Стабилизированная фармацевтическая композиция, содержащая блокатор кальция |
| MXPA03005882A (es) * | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
| US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| EP1309554A1 (en) * | 2000-12-29 | 2003-05-14 | Synthon Licensing, Ltd. | Amide derivative of amlodipine |
| HRP20030526A2 (en) * | 2000-12-29 | 2005-06-30 | Pfizer Limited | Process for making amlodipine maleate |
| KR100467669B1 (ko) * | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
| TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
| EP3522872B1 (en) | 2016-10-07 | 2021-08-11 | Silvergate Pharmaceuticals, Inc. | Amlodipine formulations |
| US10799453B2 (en) | 2018-04-11 | 2020-10-13 | Silvergate Pharmaceuticals, Inc. | Amlodipine formulations |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| US4983740A (en) | 1986-08-04 | 1991-01-08 | Adir Et Compagnie | Process for 1,4-dihydropyridine compounds |
| GB8710493D0 (en) | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
| US5155120A (en) | 1991-01-14 | 1992-10-13 | Pfizer Inc | Method for treating congestive heart failure |
| WO1993006082A1 (en) | 1991-09-13 | 1993-04-01 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropyridines |
| US5389654A (en) | 1992-11-26 | 1995-02-14 | Lek, Tovarna, Farmacevtskih In Kemicnih . . . | 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate |
| HU221810B1 (hu) | 1997-08-12 | 2003-01-28 | EGIS Gyógyszergyár Rt. | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
| ZA9810320B (en) | 1997-11-14 | 2000-05-11 | Gea Farmaceutisk Fabrik As | Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose. |
| PL189666B1 (pl) | 1998-04-09 | 2005-09-30 | Adamed Sp Z Oo | Sposób otrzymywania benzenosulfonianu amlodypiny |
| GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
| ES2151850B1 (es) | 1998-10-26 | 2001-08-16 | Esteve Quimica Sa | Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente. |
| GB9827387D0 (en) | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel process |
| GB9827431D0 (en) | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel compound |
| CA2433284A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Reference standards and processes for determining the purity or stability of amlodipine maleate |
| HRP20030526A2 (en) * | 2000-12-29 | 2005-06-30 | Pfizer Limited | Process for making amlodipine maleate |
| AT5874U1 (de) * | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| GB0114709D0 (en) | 2001-06-15 | 2001-08-08 | Pfizer Ltd | Stabilised formulations of amlodipine maleate |
-
2001
- 2001-08-15 CA CA002433191A patent/CA2433191A1/en not_active Abandoned
- 2001-08-15 EP EP01974985A patent/EP1309558A1/en not_active Withdrawn
- 2001-08-15 WO PCT/NL2001/000603 patent/WO2002053540A1/en not_active Ceased
- 2001-08-15 GB GB0131064A patent/GB2372036B/en not_active Expired - Fee Related
- 2001-08-15 BR BR0116553-4A patent/BR0116553A/pt not_active Application Discontinuation
- 2001-08-15 MX MXPA03005886A patent/MXPA03005886A/es active IP Right Grant
- 2001-08-27 US US09/938,817 patent/US6479525B2/en not_active Expired - Fee Related
- 2001-10-02 DE DE20116170U patent/DE20116170U1/de not_active Ceased
- 2001-11-05 BE BE2001/0712A patent/BE1014455A6/nl not_active IP Right Cessation
- 2001-12-20 ZA ZA200110470A patent/ZA200110470B/xx unknown
- 2001-12-21 IE IE20011105A patent/IES20011105A2/en not_active IP Right Cessation
- 2001-12-27 HU HU0105456A patent/HUP0105456A3/hu unknown
- 2001-12-28 CA CA002366391A patent/CA2366391C/en not_active Expired - Fee Related
- 2001-12-28 GR GR20010100602A patent/GR1004124B/el unknown
-
2003
- 2003-06-26 CR CR7011A patent/CR7011A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GR1004124B (el) | 2003-01-24 |
| BR0116553A (pt) | 2004-02-03 |
| GB2372036B (en) | 2004-05-19 |
| CA2433191A1 (en) | 2002-07-11 |
| HUP0105456A2 (en) | 2002-10-28 |
| EP1309558A1 (en) | 2003-05-14 |
| HUP0105456A3 (en) | 2004-01-28 |
| MXPA03005886A (es) | 2005-04-19 |
| GB0131064D0 (en) | 2002-02-13 |
| CA2366391A1 (en) | 2002-06-29 |
| BE1014455A6 (nl) | 2003-10-07 |
| IES20011105A2 (en) | 2002-12-30 |
| US6479525B2 (en) | 2002-11-12 |
| HU0105456D0 (en) | 2002-02-28 |
| GB2372036A (en) | 2002-08-14 |
| WO2002053540A1 (en) | 2002-07-11 |
| DE20116170U1 (de) | 2002-04-04 |
| CA2366391C (en) | 2005-10-18 |
| ZA200110470B (en) | 2002-07-11 |
| US20020128296A1 (en) | 2002-09-12 |
| GR20010100602A (el) | 2002-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |