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CR20240051A - Derivados de pirazol microbiocidas - Google Patents

Derivados de pirazol microbiocidas

Info

Publication number
CR20240051A
CR20240051A CR20240051A CR20240051A CR20240051A CR 20240051 A CR20240051 A CR 20240051A CR 20240051 A CR20240051 A CR 20240051A CR 20240051 A CR20240051 A CR 20240051A CR 20240051 A CR20240051 A CR 20240051A
Authority
CR
Costa Rica
Prior art keywords
pyrazole derivatives
microbiocidal
microbiocidal pyrazole
tautomers
fungicides
Prior art date
Application number
CR20240051A
Other languages
English (en)
Inventor
Andrew Edmunds
Peter Finkbeiner
Lars Suesse
Damien Bonvalot
Christopher Charles Scarborough
Martin Pouliot
Simon Williams
Pierre Joseph Marcel Jung
Daria Grosheva
Guillaume Brunot
Original Assignee
Syngenta Crop Protection Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Crop Protection Ag filed Critical Syngenta Crop Protection Ag
Publication of CR20240051A publication Critical patent/CR20240051A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00Disinfectants; Antimicrobial compounds or mixtures thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00Fungicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Health & Medical Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de fórmula (I) en la que los sustituyentes son como se definen en la reivindicación 1, y las sales, estereoisómeros, enantiómeros, tautómeros y <em>N</em>-óxidos agroquímicamente aceptables de estos compuestos, que pueden usarse como fungicidas.
CR20240051A 2021-08-02 2022-07-28 Derivados de pirazol microbiocidas CR20240051A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21189099 2021-08-02
EP22154772 2022-02-02
PCT/EP2022/071295 WO2023012044A1 (en) 2021-08-02 2022-07-28 Microbiocidal pyrazole derivatives

Publications (1)

Publication Number Publication Date
CR20240051A true CR20240051A (es) 2024-03-18

Family

ID=83005920

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20240051A CR20240051A (es) 2021-08-02 2022-07-28 Derivados de pirazol microbiocidas

Country Status (16)

Country Link
US (1) US20240343717A1 (es)
EP (1) EP4380933B1 (es)
JP (1) JP2024528175A (es)
KR (1) KR20240042609A (es)
AR (1) AR126615A1 (es)
AU (1) AU2022323303B2 (es)
BR (1) BR112024001979A2 (es)
CA (1) CA3226468A1 (es)
CL (1) CL2024000297A1 (es)
CO (1) CO2024001181A2 (es)
CR (1) CR20240051A (es)
IL (1) IL310395A (es)
MX (1) MX2024001442A (es)
TW (1) TW202321233A (es)
UY (1) UY39876A (es)
WO (1) WO2023012044A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR131667A1 (es) * 2023-01-27 2025-04-16 Syngenta Crop Protection Ag Derivados de pirazol microbiocidas
AR131665A1 (es) * 2023-02-01 2025-04-16 Syngenta Crop Protection Ag Composiciones fungicidas
WO2025114167A1 (en) 2023-11-28 2025-06-05 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
WO2025142780A1 (ja) * 2023-12-25 2025-07-03 日本曹達株式会社 ピラゾール化合物および農園芸用殺菌剤
WO2025146625A1 (en) 2024-01-03 2025-07-10 Pi Industries Ltd. Pyrazole compounds for combating phytopathogenic fungi
WO2025163143A1 (en) * 2024-02-02 2025-08-07 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
WO2025191053A1 (en) * 2024-03-14 2025-09-18 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
WO2026030052A1 (en) 2024-07-31 2026-02-05 Fmc Corporation Fungicidal substituted azoles

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61107392A (ja) 1984-10-31 1986-05-26 株式会社東芝 画像処理システム
BR8600161A (pt) 1985-01-18 1986-09-23 Plant Genetic Systems Nv Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
AU613521B2 (en) 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
US5169629A (en) 1988-11-01 1992-12-08 Mycogen Corporation Process of controlling lepidopteran pests, using bacillus thuringiensis isolate denoted b.t ps81gg
CA2005658A1 (en) 1988-12-19 1990-06-19 Eliahu Zlotkin Insecticidal toxins, genes encoding these toxins, antibodies binding to them and transgenic plant cells and plants expressing these toxins
US5015630A (en) 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
NO176766C (no) 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
GB8910624D0 (en) 1989-05-09 1989-06-21 Ici Plc Bacterial strains
CA2015951A1 (en) 1989-05-18 1990-11-18 Mycogen Corporation Novel bacillus thuringiensis isolates active against lepidopteran pests, and genes encoding novel lepidopteran-active toxins
EP0427529B1 (en) 1989-11-07 1995-04-19 Pioneer Hi-Bred International, Inc. Larvicidal lectins and plant insect resistance based thereon
JPH085894B2 (ja) 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
JPH0570366A (ja) 1991-03-08 1993-03-23 Meiji Seika Kaisha Ltd 薬用組成物
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
AU669883B2 (en) 1992-03-17 1996-06-27 Astellas Pharma Inc. Depsipeptide derivative, production thereof and use thereof
JP3189011B2 (ja) 1992-04-28 2001-07-16 八洲化学工業株式会社 2−(2,6−ジフルオロフェニル)−4−(2−エトキシ−4−tert−ブチルフェニル)−2−オキサゾリン
DE4317458A1 (de) 1992-06-11 1993-12-16 Bayer Ag Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung
TW262474B (es) 1992-09-01 1995-11-11 Sankyo Co
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
CN1073560C (zh) 1993-02-19 2001-10-24 明治制果株式会社 环缩酚酸肽pf1022衍生物
DE4317457A1 (de) 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
DE69505946T2 (de) 1994-01-14 1999-04-15 Pfizer Inc., New York, N.Y. Antiparasitäre pyrrolobenzoxazin verbindungen
GB9402916D0 (en) 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
DE4437198A1 (de) 1994-10-18 1996-04-25 Bayer Ag Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden
DE4440193A1 (de) 1994-11-10 1996-05-15 Bayer Ag Verwendung von Dioxomorpholinen zur Bekämpfung von Endoparasiten, neue Dioxomorpholine und Verfahren zur ihrer Herstellung
DE19520936A1 (de) 1995-06-08 1996-12-12 Bayer Ag Ektoparasitizide Mittel
US6262058B1 (en) 1996-03-11 2001-07-17 Syngenta Crop Protection, Inc. Pyrimidin-4-one derivatives as pesticide
BR9913745B1 (pt) 1998-09-15 2011-05-31 cetonas de piridina, composição herbicida e inibidora do crescimento de plantas, seu uso, método para controle de crescimento de plantas indesejáveis, bem como método para inibir o crescimento de plantas.
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
EP1311162B1 (en) 2000-08-25 2005-06-01 Syngenta Participations AG Bacillus thurigiensis crystal protein hybrids
US7230167B2 (en) 2001-08-31 2007-06-12 Syngenta Participations Ag Modified Cry3A toxins and nucleic acid sequences coding therefor
AR037856A1 (es) 2001-12-17 2004-12-09 Syngenta Participations Ag Evento de maiz
BR0215675A (pt) 2002-04-04 2005-02-01 Valent Biosciences Corp Composição herbicida, e, métodos para proteger uma planta de safra contra a atividade herbicida de um inibidor de fotossistema i e para incrementar a seletividade de uma composição herbicida contendo um inibidor de fotossistema i
GB0303439D0 (en) 2003-02-14 2003-03-19 Pfizer Ltd Antiparasitic terpene alkaloids
CN103270041A (zh) 2010-05-06 2013-08-28 拜尔农作物科学股份公司 二噻英-四羧基-二酰亚胺的制备方法
EP2669285A4 (en) 2011-01-26 2014-06-18 Kyorin Seiyaku Kk PYRAZOLOPYRIDINE DERIVATIVE OR PHARMACEUTICALLY UNINTENTIONAL SALT OF WHICH
WO2013000941A1 (en) * 2011-06-30 2013-01-03 Syngenta Participations Ag Microbiocidal heterocycles
AU2013284775B2 (en) 2012-07-04 2015-09-17 Agro-Kanesho Co., Ltd. 2-aminonicotinic acid ester derivative and bactericide containing same as active ingredient
EA027009B1 (ru) 2012-12-19 2017-06-30 Байер Кропсайенс Акциенгезельшафт Дифторметилникотиновые инданилкарбоксамиды
US8975417B2 (en) 2013-05-27 2015-03-10 Novartis Ag Pyrazolopyrrolidine derivatives and their use in the treatment of disease
CN106164048B (zh) 2014-04-11 2020-08-18 先正达参股股份有限公司 在农业中使用的杀真菌n’-[2-甲基-6-[2-烷氧基-乙氧基]-3-吡啶基]-n-烷基-甲脒
CR20170418A (es) 2015-03-27 2017-11-09 Syngenta Participations Ag Derivados heterobicíclicos microbicidas
BR112017021183A2 (pt) 2015-04-02 2018-07-03 Bayer Cropscience Ag novos derivados de imidazolilmetila substituídos na posição 5
WO2016202742A1 (en) 2015-06-15 2016-12-22 Bayer Cropscience Aktiengesellschaft Halogen-substituted phenoxyphenylamidines and the use thereof as fungicides
KR20180035888A (ko) 2015-08-12 2018-04-06 신젠타 파티서페이션즈 아게 살미생물 헤테로바이사이클릭 유도체
MA42599A (fr) 2015-08-14 2018-06-20 Bayer Cropscience Ag Dérivés de triazole, leurs intermédiaires et leur utilisation comme fongicides
BR112018006630B8 (pt) 2015-10-02 2022-07-12 Syngenta Participations Ag Composto derivado de oxadiazol microbiocidas, composição agroquímica compreendendo o referido composto, método de controle ou prevenção da infestação de plantas úteis por microrganismos fitopatogênicos e uso de um composto
CN108137570B (zh) 2015-10-02 2022-01-28 先正达参股股份有限公司 杀微生物的噁二唑衍生物
JP6930972B2 (ja) 2015-12-02 2021-09-01 シンジェンタ パーティシペーションズ アーゲー 殺微生物性オキサジアゾール誘導体
UY37062A (es) 2016-01-08 2017-08-31 Syngenta Participations Ag Derivados de aryl oxadiazol fungicidas
HUE050995T2 (hu) 2016-03-10 2021-01-28 Syngenta Participations Ag Mikrobiocid kinolin (TIO)karboxamid származékok
AR108745A1 (es) 2016-06-21 2018-09-19 Syngenta Participations Ag Derivados de oxadiazol microbiocidas
LT3490986T (lt) 2016-07-28 2022-02-10 Idorsia Pharmaceuticals Ltd Piperidino cxcr7 receptoriaus moduliatoriai
SI3522715T1 (sl) 2016-10-06 2021-07-30 Syngenta Participations Ag Mikrobiocidni derivati oksadizola
WO2018153707A1 (en) 2017-02-22 2018-08-30 Basf Se Crystalline forms of a strobilurin type compound for combating phytopathogenic fungi
UY37623A (es) 2017-03-03 2018-09-28 Syngenta Participations Ag Derivados de oxadiazol tiofeno fungicidas
EP3618629A1 (en) 2017-05-02 2020-03-11 Basf Se Fungicidal mixture comprising substituted 3-phenyl-5-(trifluoromethyl)-1,2,4-oxadiazoles
EP3638032A1 (en) 2017-06-14 2020-04-22 Syngenta Participations AG Fungicidal compositions
TW201908293A (zh) 2017-07-12 2019-03-01 美商必治妥美雅史谷比公司 作為rock抑制劑之5員及雙環雜環醯胺
BR112020011083A2 (pt) 2017-12-04 2020-11-17 Syngenta Participations Ag derivados de fenilamidina microbiocidas
CN113015433A (zh) 2018-09-14 2021-06-22 Fmc公司 杀真菌卤代甲基酮及水合物
AR116628A1 (es) 2018-10-18 2021-05-26 Syngenta Crop Protection Ag Compuestos microbiocidas
TWI846654B (zh) 2018-11-06 2024-06-21 美商富曼西公司 經取代之甲苯基殺真菌劑
AR117169A1 (es) 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas
GB201903942D0 (en) 2019-03-22 2019-05-08 Syngenta Crop Protection Ag Microbiocidal compounds
AU2020312647A1 (en) 2019-07-12 2022-02-24 Scenic Immunology B.V. N-substituted-3,4-(fused 5-ring)-5-phenyl-pyrrolidine-2-one compounds as inhibitors of isoQC and/or QC enzyme

Also Published As

Publication number Publication date
BR112024001979A2 (pt) 2024-04-30
TW202321233A (zh) 2023-06-01
EP4380933A1 (en) 2024-06-12
KR20240042609A (ko) 2024-04-02
AU2022323303B2 (en) 2024-12-12
WO2023012044A1 (en) 2023-02-09
IL310395A (en) 2024-03-01
CL2024000297A1 (es) 2024-08-16
AR126615A1 (es) 2023-10-25
UY39876A (es) 2023-02-28
EP4380933B1 (en) 2026-02-18
JP2024528175A (ja) 2024-07-26
CO2024001181A2 (es) 2024-02-26
CA3226468A1 (en) 2023-02-09
MX2024001442A (es) 2024-02-27
AU2022323303A1 (en) 2024-02-01
US20240343717A1 (en) 2024-10-17

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