CR20160192A - Formulación de farmaco de liberación retardada - Google Patents
Formulación de farmaco de liberación retardadaInfo
- Publication number
- CR20160192A CR20160192A CR20160192A CR20160192A CR20160192A CR 20160192 A CR20160192 A CR 20160192A CR 20160192 A CR20160192 A CR 20160192A CR 20160192 A CR20160192 A CR 20160192A CR 20160192 A CR20160192 A CR 20160192A
- Authority
- CR
- Costa Rica
- Prior art keywords
- formulation
- pharmaco
- delayed release
- release
- delayed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En una formulación de liberación retardada que comprende un núcleo que contiene unfármacoyun recubrimiento de liberación retardada para proporciona la liberación intestinal, la liberación del fármacoen el colon se acelera mediante la inclusión de una capa aislante entre el núcleo y el recubrimiento de liberación retardada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2013/072648 WO2015062640A1 (en) | 2013-10-29 | 2013-10-29 | A delayed release drug formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20160192A true CR20160192A (es) | 2016-07-13 |
Family
ID=49515360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20160192A CR20160192A (es) | 2013-10-29 | 2016-04-25 | Formulación de farmaco de liberación retardada |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US10799515B2 (es) |
| EP (2) | EP3062776A1 (es) |
| JP (1) | JP6273356B2 (es) |
| KR (2) | KR102237356B1 (es) |
| CN (2) | CN105555260B (es) |
| AU (2) | AU2013404367B2 (es) |
| BR (2) | BR112016004863B1 (es) |
| CA (1) | CA2923063C (es) |
| CR (1) | CR20160192A (es) |
| CU (1) | CU20160055A7 (es) |
| EA (1) | EA032504B1 (es) |
| HK (1) | HK1222547A1 (es) |
| IL (2) | IL244260B (es) |
| MA (1) | MA38847B2 (es) |
| MX (2) | MX382146B (es) |
| MY (1) | MY189394A (es) |
| NZ (2) | NZ747731A (es) |
| PH (2) | PH12020551522A1 (es) |
| SA (2) | SA114360006B1 (es) |
| SG (1) | SG11201600501UA (es) |
| TN (1) | TN2016000119A1 (es) |
| TW (3) | TWI725458B (es) |
| UA (1) | UA117260C2 (es) |
| WO (1) | WO2015062640A1 (es) |
| ZA (1) | ZA201600630B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2659881T3 (pl) | 2012-04-30 | 2018-05-30 | Tillotts Pharma Ag | Formulacja leku o opóźnionym uwalnianiu |
| CN108283000B (zh) | 2015-09-23 | 2021-04-13 | 凯瑞康宁生物工程(武汉)有限公司 | γ-羟基丁酸的前药及其组合物和用途 |
| EP3162362A1 (de) * | 2015-10-30 | 2017-05-03 | Dr. Falk Pharma Gmbh | Optimierte mesalazinhaltige hochdosistablette |
| EP3257501A1 (en) | 2016-06-14 | 2017-12-20 | Tillotts Pharma AG | Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating |
| WO2019126200A1 (en) * | 2017-12-21 | 2019-06-27 | Pepsico, Inc. | Multi-ingredient ephemeral beverage pod for making a beverage |
| ES2994844T3 (en) * | 2018-12-07 | 2025-02-03 | Tillotts Pharma Ag | Colonic drug delivery formulation |
| EP3662895A1 (en) | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | A process for manufacturing reducing sugar-free 5-asa tablet cores |
| ES3002632T3 (en) | 2018-12-07 | 2025-03-07 | Tillotts Pharma Ag | Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing |
| EP3662898A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Solid composition comprising mesalazine |
| EP3662900A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| GB201906917D0 (en) * | 2019-05-16 | 2019-07-03 | Intract Pharma Ltd | Novel compositions |
| PL4072532T3 (pl) * | 2019-12-11 | 2024-06-10 | Evonik Operations Gmbh | Postać dawkowania do zastosowania w leczeniu lub zapobieganiu chorobie |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8812490D0 (en) | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
| GB8819110D0 (en) | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
| IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
| SE8903914D0 (sv) | 1989-11-22 | 1989-11-22 | Draco Ab | Oral composition for the treatment of inflammatory bowel diseases |
| GB8926639D0 (en) | 1989-11-24 | 1990-01-17 | Agricultural & Food Res | Delayed release formulations |
| US5422121A (en) | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
| US5656290A (en) | 1993-02-26 | 1997-08-12 | The Procter & Gamble Company | Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery |
| US5914132A (en) | 1993-02-26 | 1999-06-22 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| FR2711525B1 (fr) * | 1993-10-29 | 1996-01-12 | Virbac Laboratoires | Forme Galénique à administration orale pour animaux, son procédé de préparation et ses applications. |
| US5508276A (en) | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
| CA2236605A1 (en) | 1997-05-09 | 1998-11-09 | Yves Duccini | Scale inhibitors |
| GB9722426D0 (en) | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| GB9724186D0 (en) | 1997-11-14 | 1998-01-14 | British Tech Group | Low temperature coatings |
| US6365185B1 (en) | 1998-03-26 | 2002-04-02 | University Of Cincinnati | Self-destructing, controlled release peroral drug delivery system |
| EP1108431B1 (en) | 1999-12-16 | 2003-05-02 | Laboratorio Medinfar-Produtos Farmaceuticos, S.A. | Gastroresistant multi-unitary pharmaceutical preparations containing piroxicam |
| DE10013029A1 (de) | 2000-03-17 | 2001-09-20 | Roehm Gmbh | Mehrschichtige Arzneiform für die Colonfreigabe |
| FI20000780L (fi) | 2000-04-03 | 2001-10-04 | Novasso Oy | Peroraalinen lääkemuoto lääkeaineen hallituksi vapauttamiseksi |
| GB2367002A (en) | 2000-09-25 | 2002-03-27 | British Sugar Plc | Coating composition |
| US20030035839A1 (en) | 2001-05-15 | 2003-02-20 | Peirce Management, Llc | Pharmaceutical composition for both intraoral and oral administration |
| KR20030097892A (ko) * | 2001-05-25 | 2003-12-31 | 에스에스 세야쿠 가부시키 가이샤 | 의약 배합제 |
| US7183321B2 (en) * | 2001-12-17 | 2007-02-27 | Bristol-Myers Squibb Company | Antidiabetic formulation and method |
| GB0203421D0 (en) | 2002-02-13 | 2002-04-03 | Alizyme Therapeutics Ltd | Composition |
| US20040028737A1 (en) | 2002-08-12 | 2004-02-12 | Kopran Research Laboratories Limited | Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same |
| EP1560597A4 (en) | 2002-10-29 | 2007-06-27 | Pharmacia Corp | DIFFERENTIALLY EXPRESSED CANCER GENES, POLYPEPTIDES CODED THEREIN, AND METHOD OF USE THEREOF |
| US7670627B2 (en) | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| WO2004058228A1 (en) | 2002-12-24 | 2004-07-15 | Lupin Limited | Enteric coated fluoxetine composition |
| GB0403247D0 (en) | 2004-02-13 | 2004-03-17 | Tillotts Pharma Ag | A pharmaceutical composition |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| JP2008543929A (ja) * | 2005-06-20 | 2008-12-04 | カディラ・ヘルスケア・リミテッド | デュロキセチンの調節放出型の投与製剤 |
| DE102005032806A1 (de) * | 2005-07-12 | 2007-01-18 | Röhm Gmbh | Verwendung eines teilneutralisierten, anionischen (Meth)acrylat-Copolymers als Überzug für die Herstellung einer Arzneiform mit einer Wirkstofffreisetzung bei erniedrigten pH-Werten |
| GB0607534D0 (en) * | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| WO2008020286A2 (en) | 2006-08-14 | 2008-02-21 | Torrent Pharmaceuticals Limited | Pharmaceutical compositions of duloxetine |
| TW200843802A (en) | 2007-02-09 | 2008-11-16 | Drugtech Corp | Compositions for improving gastrointestinal nutrient and drug absorption |
| JP2008214249A (ja) | 2007-03-02 | 2008-09-18 | Takeda Chem Ind Ltd | 製剤における溶出改善方法および溶出性の改善された製剤 |
| WO2008117814A1 (ja) | 2007-03-26 | 2008-10-02 | Teikoku Seiyaku Co., Ltd. | 大腸送達用経口製剤 |
| ES2759626T3 (es) | 2007-05-07 | 2020-05-11 | Evonik Operations Gmbh | Formas farmacéuticas sólidas que comprenden un recubrimiento entérico con liberación acelerada del fármaco |
| US20090162434A1 (en) | 2007-12-21 | 2009-06-25 | Disphar International Bv | Mesalazine tablet |
| GB0808537D0 (en) | 2008-05-12 | 2008-06-18 | Archimedes Dev Ltd | Compositions |
| US20110177164A1 (en) | 2008-10-06 | 2011-07-21 | Gopal Rajan | Pharmaceutical Compositions Comprising Amorphous Esomeprazole, Dosage Forms And Process Thereof |
| AU2010260129B2 (en) | 2009-06-15 | 2014-05-29 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels |
| DE102009033621A1 (de) | 2009-07-17 | 2011-01-20 | Add Technologies Ltd. | Trennschichten für pharmazeutische Zubereitungen zur Verhinderung von Wechselwirkungen zwischen Arzneistoffen und pharmazeutisch-technologischen Hilfsstoffen |
| KR101573889B1 (ko) | 2009-10-09 | 2015-12-04 | 영진약품공업주식회사 | 속효성과 지속성을 동시에 갖는 약제학적 조성물 |
| EP2384746A3 (en) * | 2010-05-05 | 2012-03-07 | Sanovel Ilac Sanayi ve Ticaret A.S. | Dual release oral tablet compositions of dexlansoprazole |
| WO2012075015A2 (en) | 2010-11-29 | 2012-06-07 | Dr. Reddy's Laboratories Ltd. | Oral metronidazole pharmaceutical compositions |
| CA2885680C (en) | 2011-09-07 | 2022-10-04 | Roland Saur-Brosch | Formulation for the controlled release of one or several substances in the digestive tract of a mammal. |
| CN102319218B (zh) * | 2011-09-22 | 2014-10-01 | 贝沃特医药技术(上海)有限公司 | 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法 |
| PL2659881T3 (pl) | 2012-04-30 | 2018-05-30 | Tillotts Pharma Ag | Formulacja leku o opóźnionym uwalnianiu |
| US9844436B2 (en) | 2012-10-26 | 2017-12-19 | Edwards Lifesciences Corporation | Aortic valve and conduit graft implant tool |
-
2013
- 2013-10-29 JP JP2016526336A patent/JP6273356B2/ja active Active
- 2013-10-29 MA MA38847A patent/MA38847B2/fr unknown
- 2013-10-29 KR KR1020207017564A patent/KR102237356B1/ko active Active
- 2013-10-29 WO PCT/EP2013/072648 patent/WO2015062640A1/en not_active Ceased
- 2013-10-29 EA EA201690596A patent/EA032504B1/ru unknown
- 2013-10-29 MX MX2016001840A patent/MX382146B/es unknown
- 2013-10-29 BR BR112016004863-6A patent/BR112016004863B1/pt not_active IP Right Cessation
- 2013-10-29 CA CA2923063A patent/CA2923063C/en active Active
- 2013-10-29 EP EP13785437.8A patent/EP3062776A1/en active Pending
- 2013-10-29 SG SG11201600501UA patent/SG11201600501UA/en unknown
- 2013-10-29 CN CN201380079616.6A patent/CN105555260B/zh active Active
- 2013-10-29 BR BR122020013726-6A patent/BR122020013726B1/pt active IP Right Grant
- 2013-10-29 HK HK16110696.8A patent/HK1222547A1/zh unknown
- 2013-10-29 NZ NZ747731A patent/NZ747731A/en unknown
- 2013-10-29 CN CN201910246206.5A patent/CN110279669B/zh active Active
- 2013-10-29 NZ NZ717159A patent/NZ717159A/en unknown
- 2013-10-29 KR KR1020167007738A patent/KR102174942B1/ko active Active
- 2013-10-29 TN TN2016000119A patent/TN2016000119A1/en unknown
- 2013-10-29 PH PH1/2020/551522A patent/PH12020551522A1/en unknown
- 2013-10-29 UA UAA201605286A patent/UA117260C2/uk unknown
- 2013-10-29 US US15/028,863 patent/US10799515B2/en active Active
- 2013-10-29 MX MX2019002162A patent/MX388063B/es unknown
- 2013-10-29 EP EP19163986.3A patent/EP3542791A1/en active Pending
- 2013-10-29 MY MYPI2016700483A patent/MY189394A/en unknown
- 2013-10-29 AU AU2013404367A patent/AU2013404367B2/en active Active
-
2014
- 2014-10-29 SA SA114360006A patent/SA114360006B1/ar unknown
- 2014-10-29 TW TW108122234A patent/TWI725458B/zh active
- 2014-10-29 TW TW108142795A patent/TWI736031B/zh active
- 2014-10-29 SA SA116370660A patent/SA116370660B1/ar unknown
- 2014-10-29 TW TW103137471A patent/TWI680774B/zh active
-
2016
- 2016-01-28 ZA ZA2016/00630A patent/ZA201600630B/en unknown
- 2016-02-15 PH PH12016500307A patent/PH12016500307B1/en unknown
- 2016-02-23 IL IL244260A patent/IL244260B/en unknown
- 2016-04-25 CR CR20160192A patent/CR20160192A/es unknown
- 2016-04-26 CU CUP2016000055A patent/CU20160055A7/es unknown
-
2019
- 2019-03-14 IL IL265381A patent/IL265381B/en unknown
-
2020
- 2020-02-25 AU AU2020201365A patent/AU2020201365B2/en active Active
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