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CR20140325A - Nuevos derivados de morofolinilo útiles como inhibodores de mogat-2- - Google Patents

Nuevos derivados de morofolinilo útiles como inhibodores de mogat-2-

Info

Publication number
CR20140325A
CR20140325A CR20140325A CR20140325A CR20140325A CR 20140325 A CR20140325 A CR 20140325A CR 20140325 A CR20140325 A CR 20140325A CR 20140325 A CR20140325 A CR 20140325A CR 20140325 A CR20140325 A CR 20140325A
Authority
CR
Costa Rica
Prior art keywords
morofolinyl
mogat
inhibitors
derivatives
new useful
Prior art date
Application number
CR20140325A
Other languages
English (en)
Inventor
Maria Rosario Gonzalez-Garcia
Maria Carmen Fernandez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48905712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140325(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR20140325A publication Critical patent/CR20140325A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a compuestos de Fórmula I, o una sal farmacéutica de los mismos, métodos para tratar hipertrigliceridemia usando los compuestos; y a un proceso para preparar los compuestos. WO 2013/116065 A1.
CR20140325A 2012-01-31 2014-07-08 Nuevos derivados de morofolinilo útiles como inhibodores de mogat-2- CR20140325A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12382037 2012-01-31
US201261617093P 2012-03-29 2012-03-29
EP12382433 2012-11-06

Publications (1)

Publication Number Publication Date
CR20140325A true CR20140325A (es) 2014-08-25

Family

ID=48905712

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140325A CR20140325A (es) 2012-01-31 2014-07-08 Nuevos derivados de morofolinilo útiles como inhibodores de mogat-2-

Country Status (23)

Country Link
US (1) US8993568B2 (es)
EP (1) EP2809661B1 (es)
JP (1) JP5852269B2 (es)
KR (1) KR20140107641A (es)
CN (1) CN104080777B (es)
AP (1) AP2014007793A0 (es)
AU (1) AU2013215549B2 (es)
BR (1) BR112014018712A8 (es)
CA (1) CA2859992A1 (es)
CL (1) CL2014001862A1 (es)
CO (1) CO7020914A2 (es)
CR (1) CR20140325A (es)
DO (1) DOP2014000177A (es)
EA (1) EA024182B1 (es)
ES (1) ES2571577T3 (es)
GT (1) GT201400169A (es)
IL (1) IL233542A0 (es)
MX (1) MX2014008604A (es)
PE (1) PE20141789A1 (es)
PH (1) PH12014501712B1 (es)
SG (1) SG11201404508XA (es)
WO (1) WO2013116065A1 (es)
ZA (1) ZA201405227B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2807147A1 (en) 2012-01-23 2014-12-03 Eli Lilly and Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
TW201343629A (zh) 2012-01-31 2013-11-01 Lilly Co Eli 可作為ｍｏｇａｔ－２抑制劑之新穎芐磺醯胺衍生物
AP2014007793A0 (en) 2012-01-31 2014-07-31 Lilly Co Eli Novel morpholinyl derivatives useful as mogat-2 inhibitors
AU2013341584A1 (en) 2012-11-06 2015-04-30 Eli Lilly And Company Novel benzyl sulfonamide compounds useful as MoGAT-2 inhibitors
JPWO2017110841A1 (ja) 2015-12-21 2018-10-11 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する非芳香族複素環誘導体
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
JP7608166B2 (ja) 2019-01-11 2025-01-06 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有するジヒドロピラゾロピラジノン誘導体

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
WO2000006083A2 (en) 1998-07-31 2000-02-10 Eli Lilly And Company Sulfonamide derivatives
US6387954B1 (en) 1998-07-31 2002-05-14 Eli Lilly And Company Alkenyl sulphonamide derivatives
GB0408777D0 (en) 2004-04-20 2004-05-26 Glaxo Group Ltd Compounds
EP1659113A1 (en) 2004-11-08 2006-05-24 Evotec AG Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1)
EP1655283A1 (en) 2004-11-08 2006-05-10 Evotec OAI AG 11beta-HSD1 Inhibitors
JPWO2008038768A1 (ja) 2006-09-28 2010-01-28 大日本住友製薬株式会社 二環性ピリミジン構造を有する化合物及びそれを含有する医薬組成物
TW200831092A (en) * 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
JP2011506298A (ja) * 2007-12-05 2011-03-03 アストラゼネカ アクチボラグ 新規化合物ｉｖ
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009119726A1 (ja) 2008-03-28 2009-10-01 萬有製薬株式会社 メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体
US20110275637A1 (en) * 2008-06-04 2011-11-10 Emma Chapman Piperazine derivatives and their use as leptin receptor modulators
US20110275647A1 (en) 2009-02-23 2011-11-10 Msd K.K. Pyrimidin-4-(3h)-one derivatives
JP2014051434A (ja) 2010-12-28 2014-03-20 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体
EP2807147A1 (en) 2012-01-23 2014-12-03 Eli Lilly and Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
TW201343629A (zh) 2012-01-31 2013-11-01 Lilly Co Eli 可作為ｍｏｇａｔ－２抑制劑之新穎芐磺醯胺衍生物
AP2014007793A0 (en) 2012-01-31 2014-07-31 Lilly Co Eli Novel morpholinyl derivatives useful as mogat-2 inhibitors
AU2013341584A1 (en) 2012-11-06 2015-04-30 Eli Lilly And Company Novel benzyl sulfonamide compounds useful as MoGAT-2 inhibitors

Also Published As

Publication number Publication date
IL233542A0 (en) 2014-08-31
EP2809661B1 (en) 2016-04-06
BR112014018712A2 (es) 2017-06-20
US20150005305A1 (en) 2015-01-01
AU2013215549A1 (en) 2014-07-17
KR20140107641A (ko) 2014-09-04
AU2013215549B2 (en) 2015-09-03
CA2859992A1 (en) 2013-08-08
ES2571577T3 (es) 2016-05-26
JP5852269B2 (ja) 2016-02-03
GT201400169A (es) 2015-08-27
JP2015504917A (ja) 2015-02-16
BR112014018712A8 (pt) 2017-07-11
PE20141789A1 (es) 2014-11-19
EP2809661A1 (en) 2014-12-10
CN104080777B (zh) 2015-12-09
AP2014007793A0 (en) 2014-07-31
EA024182B1 (ru) 2016-08-31
EA201491227A1 (ru) 2015-01-30
PH12014501712A1 (en) 2014-10-13
SG11201404508XA (en) 2014-10-30
US8993568B2 (en) 2015-03-31
CO7020914A2 (es) 2014-08-11
PH12014501712B1 (en) 2014-10-13
CN104080777A (zh) 2014-10-01
WO2013116065A1 (en) 2013-08-08
HK1199024A1 (zh) 2015-06-19
ZA201405227B (en) 2016-05-25
MX2014008604A (es) 2014-08-22
CL2014001862A1 (es) 2014-11-14
DOP2014000177A (es) 2014-08-31

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