CO5380019A1 - Azalidas de 13 miembros utiles como agentes antibioticos - Google Patents
Azalidas de 13 miembros utiles como agentes antibioticosInfo
- Publication number
- CO5380019A1 CO5380019A1 CO99072704A CO99072704A CO5380019A1 CO 5380019 A1 CO5380019 A1 CO 5380019A1 CO 99072704 A CO99072704 A CO 99072704A CO 99072704 A CO99072704 A CO 99072704A CO 5380019 A1 CO5380019 A1 CO 5380019A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- hydrogen
- aryl
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 13
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 12
- 125000005865 C2-C10alkynyl group Chemical group 0.000 abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 abstract 11
- 239000001257 hydrogen Substances 0.000 abstract 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 11
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 abstract 4
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 3
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto de fórmula 2 <EMI FILE="99072704_1" ID="1" IMF=JPEG >o una sal farmacéuticamente aceptable del mismo, en el que:X es -C(O)- o -CH(OR7); yR2 es hidrógeno o alquilo C1-C4;cada R7 es independientemente hidrógeno, alquilo C1-C20, alquenilo C2-C20, alquinilo C2-C20, -C(O)alquilo C1-C20, -C(O)alquenilo C2-C20, -C(O)alquinilo C2-C20, -C(O)N(H)alquilo C1-C10, -C(O)N(H)alquenilo C2-C20, -C(O)N(H)alquinilo C2-C20, -SO2(O)alquilo C1-C20, -SO2(O)alquenilo C2-C20, -SO2(O)alquinilo C2-C20 o -PO42-;R8 es hidrógeno o metilo: <EMI FILE="99072704_2" ID="2" IMF=JPEG >R9 es 2 o 4"-oxacladinosilo; yR5 es hidrógeno, alquilo C1-C10, alquenilo C2-C10, alquinilo C2-C10, ciano, -CH2S(O)p alquilo C1-C10, -CH2S(O)p alquenilo C2-C10, -CH2S(O)p alquinilo C2-C10, en los que p es un número entero que varía de 0 a 2, -CH2O(alquilo C1-C10), -CH2O(alquenilo C2-C10), -CH2O(alquinilo C2-C10), -CH2N(hidrógeno, alquilo C1-C10, alquenilo C2-C10 o alquinilo C2-C10)(hidrógeno, alquilo C1-C10, alquenilo C2-C10 o aIquinilo C2-C10), -(CH2)m(arilo C6-C10) o -(CH2)m(heteroarilo de 5-10 miembros), en los que m es un número entero que varía de 0 a 4 y en los que los restos alquilo, alquenilo, alquinilo, arilo y heteroarilo de los grupos anteriores están opcionalmente sustituidos con 1 a 3 sustituyentes seleccionados independientemente entre halo, ciano, nitro, trifluorometilo, azido, -C(O)alquilo C1-C10, -C(O)alquenilo C2-C10, -C(O)alquinilo C2-C10, -OC(O)alquilo C1-C10, -OC(O)alquenilo C2-C10, -OC(O)alquinilo C2-C10, -N(hidrógeno, alquilo C1-C10, alquenilo C2-C10 o alquinilo C2-C10)C(O)(alquilo C1-C10, alquenilo C2-C10 o alquinilo C2-C10), -C(O)N(hidrógeno, alquilo C1-C10, alquenilo C2-C10 o alquinilo C2-C10)(hidrógeno, alquilo C1-C10, alquenilo C2-C10 o alquinilo C2-C10), -N(hidrógeno, alquilo C1-C10, alquenilo C2-C10 o alquinilo C2-C10)(hidrógeno, alquilo C1-C10, alquenilo C2-C10 o alquinilo C2-C10), alcoxi C1-C10, arilo C6-C10 y heterociclo de 5-10 miembros, hidroxi, alquilo C1-C6, alcoxi C1-C6, arilo C6-C10 y heteroarilo de 5-10 miembros.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10939998P | 1998-11-20 | 1998-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5380019A1 true CO5380019A1 (es) | 2004-03-31 |
Family
ID=22327457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99072704A CO5380019A1 (es) | 1998-11-20 | 1999-11-18 | Azalidas de 13 miembros utiles como agentes antibioticos |
Country Status (46)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN1998000086A (es) | 1997-06-11 | 1999-03-08 | Pfizer Prod Inc | Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos. |
| AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| UA70972C2 (uk) * | 1998-11-20 | 2004-11-15 | Пфайзер Продактс Інк. | 13-членні азаліди і їх застосування як антибіотиків |
| CN1351608A (zh) * | 1999-05-24 | 2002-05-29 | 辉瑞产品公司 | 13－甲基红霉素衍生物 |
| US6465437B1 (en) * | 1999-06-30 | 2002-10-15 | Pfizer Inc. | Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition |
| OA12257A (en) * | 2000-04-27 | 2003-11-06 | Pfizer Prod Inc | the use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals. |
| CA2445306C (en) * | 2001-04-27 | 2008-02-12 | Pfizer Products Inc. | Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives |
| JP4311203B2 (ja) * | 2001-08-08 | 2009-08-12 | 大正製薬株式会社 | １１ａ−アザライド化合物及びその製造方法 |
| WO2004080391A2 (en) * | 2003-03-10 | 2004-09-23 | Optimer Pharmaceuticals, Inc. | Novel antibacterial agents |
| WO2004108744A2 (en) * | 2003-05-19 | 2004-12-16 | Prasad K Deshpande | Azalides and azaketolides having antimicrobial activity |
| EP1689434A1 (en) * | 2003-11-21 | 2006-08-16 | Pfizer Products Inc. | The use of anti biotics as vaccine adjuvants |
| EP1985620A4 (en) * | 2006-02-07 | 2012-08-15 | Taisho Pharmaceutical Co Ltd | COMPOUND 10a-AZALIDE |
| JPWO2009019868A1 (ja) * | 2007-08-06 | 2010-10-28 | 大正製薬株式会社 | １０ａ、１２位架橋型１０ａ−アザライド化合物 |
| WO2009139181A1 (ja) * | 2008-05-15 | 2009-11-19 | 大正製薬株式会社 | ４員環構造を有する１０ａ－アザライド化合物 |
| US8940880B2 (en) | 2010-09-20 | 2015-01-27 | Novartis Ag | Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group |
| CN102295672B (zh) * | 2011-07-13 | 2014-06-04 | 武汉回盛生物科技有限公司 | 一种泰拉菌素的合成方法 |
| WO2013013834A1 (en) | 2011-07-27 | 2013-01-31 | Farma Grs, D.O.O. | New crystalline forms of tulathromycin |
| CN102786569B (zh) * | 2012-09-07 | 2016-12-07 | 安徽中升药业有限公司 | 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法 |
| WO2015014907A1 (en) * | 2013-07-31 | 2015-02-05 | Farma Grs, D.O.O. | Process for preparation of tulathromycin |
| CN109748942A (zh) * | 2014-05-16 | 2019-05-14 | 普莱柯生物工程股份有限公司 | 一种大环内酯类化合物 |
| CN104725446B (zh) * | 2015-03-26 | 2017-10-27 | 宁夏泰瑞制药股份有限公司 | 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法 |
| US20230093692A1 (en) * | 2018-11-19 | 2023-03-23 | Zikani Therapeutics, Inc. | C10-Alkylene Substituted 13-Membered Macrolides and Uses Thereof |
| IL283185B2 (en) * | 2018-11-19 | 2024-06-01 | Zikani Therapeutics Inc | Macrolides with 13 members converted to C10-cyclic and their uses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU43116B (en) | 1979-04-02 | 1989-04-30 | Pliva Pharm & Chem Works | Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox |
| SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| YU44599B (en) * | 1986-09-12 | 1990-10-31 | Pliva Pharm & Chem Works | Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals |
| US5106961A (en) | 1987-05-26 | 1992-04-21 | Eli Lilly And Company | Erythromycin ring-contracted derivatives |
| SI9011409A (en) | 1990-07-18 | 1995-10-31 | Pliva Pharm & Chem Works | O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them |
| HRP931480B1 (en) * | 1993-12-08 | 1997-08-31 | Sour Pliva | 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A |
| GB2327084A (en) * | 1997-07-08 | 1999-01-13 | Merck & Co Inc | 9a-Aza-3-ketolide antibiotics |
| UA70972C2 (uk) * | 1998-11-20 | 2004-11-15 | Пфайзер Продактс Інк. | 13-членні азаліди і їх застосування як антибіотиків |
-
1999
- 1999-09-11 UA UA2001053376A patent/UA70972C2/uk unknown
- 1999-11-09 IL IL14263199A patent/IL142631A0/xx unknown
- 1999-11-09 NZ NZ511199A patent/NZ511199A/en not_active IP Right Cessation
- 1999-11-09 PL PL347784A patent/PL198580B1/pl unknown
- 1999-11-09 BR BRPI9915480A patent/BRPI9915480B1/pt not_active IP Right Cessation
- 1999-11-09 HU HU0104313A patent/HU229008B1/hu active Protection Beyond IP Right Term
- 1999-11-09 NO NO20012464A patent/NO319796B1/no not_active IP Right Cessation
- 1999-11-09 ID IDW00200101093A patent/ID28548A/id unknown
- 1999-11-09 CN CNA2008100813586A patent/CN101367853A/zh active Pending
- 1999-11-09 ES ES99954277T patent/ES2216581T3/es not_active Expired - Lifetime
- 1999-11-09 EA EA200100416A patent/EA005156B1/ru not_active IP Right Cessation
- 1999-11-09 WO PCT/IB1999/001803 patent/WO2000031097A1/en not_active Ceased
- 1999-11-09 RS YUP-334/01A patent/RS50302B/sr unknown
- 1999-11-09 AP APAP/P/2001/002142A patent/AP2001002142A0/en unknown
- 1999-11-09 KR KR10-2001-7006301A patent/KR100477774B1/ko not_active Expired - Lifetime
- 1999-11-09 SI SI9930572T patent/SI1131331T1/xx unknown
- 1999-11-09 BR BRPI9915480A patent/BRPI9915480B8/pt not_active IP Right Cessation
- 1999-11-09 PT PT99954277T patent/PT1131331E/pt unknown
- 1999-11-09 OA OA1200100120A patent/OA11713A/en unknown
- 1999-11-09 AU AU10686/00A patent/AU766106B2/en not_active Expired
- 1999-11-09 EA EA200400701A patent/EA009729B1/ru not_active IP Right Cessation
- 1999-11-09 DK DK99954277T patent/DK1131331T3/da active
- 1999-11-09 EP EP99954277A patent/EP1131331B1/en not_active Expired - Lifetime
- 1999-11-09 CA CA002351429A patent/CA2351429C/en not_active Expired - Lifetime
- 1999-11-09 HR HR20010374A patent/HRP20010374B1/xx not_active IP Right Cessation
- 1999-11-09 HK HK02102807.7A patent/HK1041269A1/zh unknown
- 1999-11-09 JP JP2000583925A patent/JP3842973B2/ja not_active Expired - Lifetime
- 1999-11-09 SK SK663-2001A patent/SK284607B6/sk not_active IP Right Cessation
- 1999-11-09 ME MEP-2008-719A patent/ME00467B/me unknown
- 1999-11-09 DE DE1999615336 patent/DE69915336T2/de not_active Expired - Lifetime
- 1999-11-09 CN CN99813464A patent/CN1326460A/zh active Pending
- 1999-11-09 CZ CZ20011754A patent/CZ303099B6/cs not_active IP Right Cessation
- 1999-11-09 AT AT99954277T patent/ATE260927T1/de active
- 1999-11-15 TW TW092131563A patent/TWI243825B/zh not_active IP Right Cessation
- 1999-11-15 TW TW088119885A patent/TWI243824B/zh not_active IP Right Cessation
- 1999-11-17 TN TNTNSN99214A patent/TNSN99214A1/fr unknown
- 1999-11-17 DZ DZ990244A patent/DZ2944A1/xx active
- 1999-11-17 MA MA25850A patent/MA26707A1/fr unknown
- 1999-11-17 PA PA19998485601A patent/PA8485601A1/es unknown
- 1999-11-17 UY UY25805A patent/UY25805A1/es not_active Application Discontinuation
- 1999-11-17 EG EG147699A patent/EG23823A/xx active
- 1999-11-18 US US09/442,530 patent/US6329345B1/en not_active Expired - Lifetime
- 1999-11-18 MY MYPI99005021A patent/MY122353A/en unknown
- 1999-11-18 CO CO99072704A patent/CO5380019A1/es active IP Right Grant
- 1999-11-18 GT GT199900198A patent/GT199900198A/es unknown
- 1999-11-18 AR ARP990105876A patent/AR019496A1/es active IP Right Grant
- 1999-11-18 PE PE1999001166A patent/PE20001378A1/es not_active Application Discontinuation
-
2001
- 2001-04-16 IL IL142631A patent/IL142631A/en not_active IP Right Cessation
- 2001-04-17 IS IS5918A patent/IS2350B/is unknown
- 2001-05-17 ZA ZA200104019A patent/ZA200104019B/en unknown
- 2001-06-14 BG BG105600A patent/BG65107B1/bg unknown
-
2005
- 2005-02-18 NO NO20050904A patent/NO329629B1/no not_active IP Right Cessation
- 2005-02-18 NO NO20050893A patent/NO330249B1/no not_active IP Right Cessation
-
2007
- 2007-02-15 AR ARP070100662A patent/AR059523A2/es active IP Right Grant
- 2007-02-15 AR ARP070100663A patent/AR059524A2/es active IP Right Grant
-
2008
- 2008-02-11 IL IL189430A patent/IL189430A/en not_active IP Right Cessation
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