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CO5380013A1 - Compuestos de amina ciclica, su produccion y su uso - Google Patents

Compuestos de amina ciclica, su produccion y su uso

Info

Publication number
CO5380013A1
CO5380013A1 CO00074305A CO00074305A CO5380013A1 CO 5380013 A1 CO5380013 A1 CO 5380013A1 CO 00074305 A CO00074305 A CO 00074305A CO 00074305 A CO00074305 A CO 00074305A CO 5380013 A1 CO5380013 A1 CO 5380013A1
Authority
CO
Colombia
Prior art keywords
substituted
group
heterocyclic group
hydrocarbon
bond
Prior art date
Application number
CO00074305A
Other languages
English (en)
Inventor
Imamura Shinichi
Hashiguchi Shohei
Hattori Taeko
Nishimura Osamu
Kanzaki Naoyuki
Baba Masanori
Sugihara Yoshihiro
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26554466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5380013(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CO5380013A1 publication Critical patent/CO5380013A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Un compuesto de la fórmula:<EMI FILE="00074305_1" ID="1" IMF=JPEG >(donde R1 es un átomo de hidrógeno, un grupo de hidrocarburos que puede ser sustituido, un grupo heterocíclico no aromático que puede ser sustituido, R2 es un grupo de hidrocarburos que puede ser sustituido, un grupo heterocíclico no aromático que puede ser sustituido, o R1 y R2 pueden combinarse entre sí con A para formar un grupo heterocíclíco que puede ser sustituido; A es N o N - R5. Y- (R5 es un grupo de hidrocarburos; Y- es un contraanión); R3 es un grupo de hidrocarburos cíclicos que puede ser sustituido o un grupo heterocíclico que puede ser sustituido; o n es 0 o 1; R4 es un átomo de hidrógeno, un grupo de hidrocarburos que puede ser sustituido, un grupo heterocíclico que puede ser sustituido, un grupo alcoxi que puede ser sustituido, un grupo ariloxi que puede ser sustituido o un grupo amino que puede ser sustituido, E es un grupo de hidrocarburos alifáticos divalentes que puede ser sustituido por uno o más grupos(s) distintos(s) de oxo; G1 es un enlace, CO o SO2; G2 es CO, SO2, NHCO, CONH u OCO: J es metina o un átomo de nitrógeno; y cada uno de Q y R es un enlace o un hidrocarburo alifático C1-3 divalente que puede ser sustituido; con la condición de que J sea metina cuando Ge es OCO, que Q o R -uno de ellos no sea un enlace cuando el otro es un enlace y que cada uno de los siguientes, Q y R, no esté sustituido por uno o más grupo(s) oxo cuando G1 es un enlace) o una sal del mismo.
CO00074305A 1999-10-01 2000-09-29 Compuestos de amina ciclica, su produccion y su uso CO5380013A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28208899 1999-10-01
JP2000046749 2000-02-18

Publications (1)

Publication Number Publication Date
CO5380013A1 true CO5380013A1 (es) 2004-03-31

Family

ID=26554466

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00074305A CO5380013A1 (es) 1999-10-01 2000-09-29 Compuestos de amina ciclica, su produccion y su uso

Country Status (22)

Country Link
US (2) US6562978B1 (es)
EP (2) EP1886994A1 (es)
JP (2) JP3814136B2 (es)
KR (1) KR20020060190A (es)
CN (1) CN1390201A (es)
AR (1) AR025884A1 (es)
AT (1) ATE400555T1 (es)
AU (1) AU7448700A (es)
BR (1) BRPI0014428B8 (es)
CA (2) CA2608807A1 (es)
CO (1) CO5380013A1 (es)
CY (1) CY1108403T1 (es)
DE (1) DE60039446D1 (es)
DK (1) DK1220842T3 (es)
ES (1) ES2310173T3 (es)
HU (1) HUP0300138A3 (es)
NO (1) NO20021450L (es)
PE (1) PE20010628A1 (es)
PL (1) PL203984B1 (es)
PT (1) PT1220842E (es)
WO (1) WO2001025200A1 (es)
ZA (1) ZA200202593B (es)

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Also Published As

Publication number Publication date
ZA200202593B (en) 2003-04-03
AR025884A1 (es) 2002-12-18
ES2310173T3 (es) 2009-01-01
EP1886994A1 (en) 2008-02-13
DE60039446D1 (de) 2008-08-21
PE20010628A1 (es) 2001-06-18
KR20020060190A (ko) 2002-07-16
NO20021450D0 (no) 2002-03-22
BRPI0014428B8 (pt) 2021-05-25
BR0014428A (pt) 2002-06-11
CN1390201A (zh) 2003-01-08
JP2003048880A (ja) 2003-02-21
US20030114443A1 (en) 2003-06-19
EP1220842A1 (en) 2002-07-10
DK1220842T3 (da) 2008-11-10
PL203984B1 (pl) 2009-11-30
US6562978B1 (en) 2003-05-13
NO20021450L (no) 2002-06-03
JP3814136B2 (ja) 2006-08-23
AU7448700A (en) 2001-05-10
HUP0300138A3 (en) 2003-06-30
PL356034A1 (en) 2004-06-14
CA2385938C (en) 2010-02-16
HUP0300138A2 (en) 2003-05-28
CA2608807A1 (en) 2001-04-12
US7348324B2 (en) 2008-03-25
HK1046905A1 (en) 2003-01-30
CY1108403T1 (el) 2014-02-12
JP2001302633A (ja) 2001-10-31
BRPI0014428B1 (pt) 2016-08-02
PT1220842E (pt) 2008-10-17
WO2001025200A1 (en) 2001-04-12
ATE400555T1 (de) 2008-07-15
CA2385938A1 (en) 2001-04-12
EP1220842B1 (en) 2008-07-09

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