AR030279A1 - Derivados de fenilamida para-amino sustituida activadora de la glucoquinasa, un procedimiento para su preparacion, composiciones farmaceuticas y el empleo de dichos derivados para la preparacion de medicamentos. - Google Patents
Derivados de fenilamida para-amino sustituida activadora de la glucoquinasa, un procedimiento para su preparacion, composiciones farmaceuticas y el empleo de dichos derivados para la preparacion de medicamentos.Info
- Publication number
- AR030279A1 AR030279A1 ARP010102124A ARP010102124A AR030279A1 AR 030279 A1 AR030279 A1 AR 030279A1 AR P010102124 A ARP010102124 A AR P010102124A AR P010102124 A ARP010102124 A AR P010102124A AR 030279 A1 AR030279 A1 AR 030279A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- derivatives
- group
- annular
- nitrogen
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical class NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 150000001721 carbon Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 229910052757 nitrogen Chemical group 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 239000011593 sulfur Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados fenilamida para-amino sustituido, que comprenden una amida seleccionada a partir del grupo constituido por un compuesto de formula 1 en donde X es -C(O)- o -S(O)2-, R es perfluor-alquilo inferior, alquilo inferior, R5R4N-, alcoxicarbonilo inferior, un anillo heteroaromático, unido por un átomo de carbono anular, que contiene de 5 a 6 miembros de anillo con 1 a 3 heteroátomos seleccionados a partir del grupo constituido por oxígeno, azufre y nitrogeno, arilo no sustituido que contiene C6-10 anulares, un arilo sustituido con nitro o con alquilo inferior, cuyo arilo contiene C6-10 anulares, o un anillo saturado de cicloheteroalquilo de 5 o 6 miembros, unido por un átomo de carbono anular que contiene 1 o 2 heteroátomos seleccionados a partir del grupo constituido por oxígeno, nitrogeno y azufre o cicloalquilo que tiene C5-6; R1 es un cicloalquilo C5-6; R2 es un anillo heteroaromático de 5 o 6 miembros unido por un átomo de carbono anular al grupo amida en el resto del compuesto, cuyo anillo heteroaromático contiene de 1 a 3 heteroátomos seleccionados a partir del grupo constituido por oxígeno, azufre y nitrogeno, siendo un primer heteroátomo, nitrogeno, que está adyacente al átomo de carbono anular de union, estando dicho anillo heteroaromático no sustituido o monosustituidoen una posicion en un átomo de carbono de union, con un sustituyente seleccionado a partir del alquilo inferior, y formula û(CH2)n-COOR7, n e y son independientemente, un numero entero de 0 a 4; R4, R5 y R7 son, independientemente, hidrogeno o alquilo inferior; y * denota el átomo de carbono asimétrico y una sal farmacéuticamente aceptable de la misma; un procedimiento para su preparacion, composiciones farmacéuticas y el empleo de dichos derivados para la preparacion de medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20238900P | 2000-05-08 | 2000-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030279A1 true AR030279A1 (es) | 2003-08-20 |
Family
ID=22749673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102124A AR030279A1 (es) | 2000-05-08 | 2001-05-04 | Derivados de fenilamida para-amino sustituida activadora de la glucoquinasa, un procedimiento para su preparacion, composiciones farmaceuticas y el empleo de dichos derivados para la preparacion de medicamentos. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1283830B1 (es) |
| JP (1) | JP3971189B2 (es) |
| KR (1) | KR100519826B1 (es) |
| CN (1) | CN1185220C (es) |
| AR (1) | AR030279A1 (es) |
| AT (1) | ATE398611T1 (es) |
| AU (2) | AU6591401A (es) |
| BR (1) | BR0110703A (es) |
| CA (1) | CA2407763C (es) |
| DE (1) | DE60134470D1 (es) |
| DK (1) | DK1283830T3 (es) |
| EC (1) | ECSP014062A (es) |
| ES (1) | ES2307623T3 (es) |
| MX (1) | MXPA02010795A (es) |
| PE (1) | PE20020049A1 (es) |
| PT (1) | PT1283830E (es) |
| UY (1) | UY26695A1 (es) |
| WO (1) | WO2001085707A1 (es) |
| ZA (1) | ZA200208503B (es) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610846B1 (en) | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| EP1724270A3 (en) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| EP1336607A1 (en) * | 2002-02-19 | 2003-08-20 | Novo Nordisk A/S | Amide derivatives as glucokinase activators |
| US6911545B2 (en) | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
| EP1458382A1 (en) | 2001-12-21 | 2004-09-22 | Novo Nordisk A/S | Amide derivatives as gk activators |
| JP4881559B2 (ja) | 2002-06-27 | 2012-02-22 | ノボ・ノルデイスク・エー／エス | 治療薬としてのアリールカルボニル誘導体 |
| CN1678311A (zh) | 2002-06-27 | 2005-10-05 | 诺沃挪第克公司 | 用作治疗剂的芳基羰基衍生物 |
| US7812167B2 (en) * | 2002-10-03 | 2010-10-12 | Novartis, Ag | Substituted (thiazol-2-yl)-amides or sulfonamides as glucokinase activators useful in the treatment of type 2 diabetes |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| AU2003297291A1 (en) * | 2003-01-06 | 2004-08-10 | Eli Lilly And Company | Substituted arylcyclopropylacetamides as glucokinase activators |
| WO2004063194A1 (en) * | 2003-01-06 | 2004-07-29 | Eli Lilly And Company | Heteroaryl compounds |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| RU2386622C9 (ru) | 2004-01-06 | 2021-04-21 | Ново Нордиск А/С | Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы |
| PT1735322E (pt) * | 2004-04-02 | 2012-01-12 | Novartis Ag | Derivados de sulfonamido-tiazolopiridina como activadores de glucoquinase úteis para o tratamento de diabetes de tipo 2 |
| US7781451B2 (en) | 2004-04-02 | 2010-08-24 | Novartis Ag | Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions |
| KR101066882B1 (ko) | 2004-12-03 | 2011-09-26 | 트랜스테크 파르마, 인크. | 헤테로방향족 글루코키나제 활성화제 |
| CA2614518A1 (en) | 2005-07-08 | 2007-01-18 | Novo-Nordisk A/S | Dicycloalkyl urea glucokinase activators |
| EP2301935A1 (en) | 2005-07-09 | 2011-03-30 | AstraZeneca AB (Publ) | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| ES2426345T3 (es) | 2005-07-20 | 2013-10-22 | Eli Lilly And Company | Compuesto unidos en posición 1-amino |
| AU2006285834A1 (en) | 2005-08-31 | 2007-03-08 | Astellas Pharma Inc. | Thiazole derivative |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| AU2006299091A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
| CA2629223C (en) | 2005-11-17 | 2013-08-06 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| JP5302012B2 (ja) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
| US8211925B2 (en) | 2006-04-28 | 2012-07-03 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP2049518B1 (en) * | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents. |
| MX2009000688A (es) | 2006-07-24 | 2009-01-30 | Hoffmann La Roche | Pirazoles como activadores de glucocinasa. |
| WO2008079787A2 (en) | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
| TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
| US8940900B2 (en) | 2007-02-28 | 2015-01-27 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
| US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
| US20100190980A1 (en) | 2007-06-21 | 2010-07-29 | Taisho Pharmaceutical Co., Ltd | Pyrazinamide compound |
| AU2009205070A1 (en) | 2008-01-18 | 2009-07-23 | Astellas Pharma Inc. | Phenyl acetamide derivative |
| US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| MX2010011778A (es) | 2008-04-28 | 2010-11-30 | Kyorin Seiyaku Kk | Derivados de ciclopentil acrilamida. |
| UY31830A (es) | 2008-05-16 | 2010-01-05 | Takeda Pharmaceutical | Activadores de glucoquinasa |
| UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
| JP5750050B2 (ja) | 2009-12-04 | 2015-07-15 | 大正製薬株式会社 | ２−ピリドン化合物 |
| US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
| EP3936608B1 (en) | 2010-03-31 | 2025-05-07 | The Scripps Research Institute | Reprogramming cells |
| US8877794B2 (en) * | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP2021526130A (ja) | 2018-06-12 | 2021-09-30 | ブイティーブイ・セラピューティクス・エルエルシー | インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用 |
| US12391658B2 (en) | 2020-02-18 | 2025-08-19 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
| KR20230048502A (ko) | 2020-06-08 | 2023-04-11 | 브이티브이 테라퓨틱스 엘엘씨 | ｛2-[3-사이클로헥실-3-(트랜스-4-프로폭시-사이클로헥실)-우레이도]-티아졸-5-일설파닐｝-아세트산의 염 또는 공결정 및 그의 용도 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4317320A1 (de) * | 1993-05-25 | 1994-12-01 | Boehringer Mannheim Gmbh | Neue Thiazolidindione und diese enthaltende Arzneimittel |
| US6011048A (en) * | 1997-01-28 | 2000-01-04 | Merck & Co., Inc. | Thiazole benzenesulfonamides as β3 agonists for treatment of diabetes and obesity |
-
2001
- 2001-04-30 CA CA002407763A patent/CA2407763C/en not_active Expired - Fee Related
- 2001-04-30 ES ES01943302T patent/ES2307623T3/es not_active Expired - Lifetime
- 2001-04-30 KR KR10-2002-7014921A patent/KR100519826B1/ko not_active Expired - Fee Related
- 2001-04-30 AT AT01943302T patent/ATE398611T1/de not_active IP Right Cessation
- 2001-04-30 AU AU6591401A patent/AU6591401A/xx active Pending
- 2001-04-30 WO PCT/EP2001/004859 patent/WO2001085707A1/en not_active Ceased
- 2001-04-30 CN CNB018092233A patent/CN1185220C/zh not_active Expired - Fee Related
- 2001-04-30 AU AU2001265914A patent/AU2001265914B2/en not_active Ceased
- 2001-04-30 MX MXPA02010795A patent/MXPA02010795A/es active IP Right Grant
- 2001-04-30 PT PT01943302T patent/PT1283830E/pt unknown
- 2001-04-30 JP JP2001582308A patent/JP3971189B2/ja not_active Expired - Fee Related
- 2001-04-30 DE DE60134470T patent/DE60134470D1/de not_active Expired - Lifetime
- 2001-04-30 BR BR0110703-8A patent/BR0110703A/pt not_active IP Right Cessation
- 2001-04-30 EP EP01943302A patent/EP1283830B1/en not_active Expired - Lifetime
- 2001-04-30 DK DK01943302T patent/DK1283830T3/da active
- 2001-05-02 PE PE2001000395A patent/PE20020049A1/es not_active Application Discontinuation
- 2001-05-04 AR ARP010102124A patent/AR030279A1/es unknown
- 2001-05-07 UY UY26695A patent/UY26695A1/es not_active Application Discontinuation
- 2001-05-08 EC EC2001004062A patent/ECSP014062A/es unknown
-
2002
- 2002-10-21 ZA ZA200208503A patent/ZA200208503B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003532719A (ja) | 2003-11-05 |
| CA2407763A1 (en) | 2001-11-15 |
| EP1283830A1 (en) | 2003-02-19 |
| AU6591401A (en) | 2001-11-20 |
| ATE398611T1 (de) | 2008-07-15 |
| UY26695A1 (es) | 2001-11-30 |
| CA2407763C (en) | 2007-04-24 |
| MXPA02010795A (es) | 2003-03-27 |
| AU2001265914B2 (en) | 2005-11-03 |
| EP1283830B1 (en) | 2008-06-18 |
| WO2001085707A1 (en) | 2001-11-15 |
| DE60134470D1 (de) | 2008-07-31 |
| JP3971189B2 (ja) | 2007-09-05 |
| PT1283830E (pt) | 2008-08-18 |
| ECSP014062A (es) | 2002-02-25 |
| ZA200208503B (en) | 2004-01-22 |
| CN1185220C (zh) | 2005-01-19 |
| KR20020094019A (ko) | 2002-12-16 |
| PE20020049A1 (es) | 2002-02-01 |
| CN1427830A (zh) | 2003-07-02 |
| KR100519826B1 (ko) | 2005-10-06 |
| ES2307623T3 (es) | 2008-12-01 |
| DK1283830T3 (da) | 2008-08-25 |
| BR0110703A (pt) | 2003-01-28 |
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