CO4900072A1 - Derivados de 1-carba-(detia)-cefalosporina - Google Patents
Derivados de 1-carba-(detia)-cefalosporinaInfo
- Publication number
- CO4900072A1 CO4900072A1 CO97054843A CO97054843A CO4900072A1 CO 4900072 A1 CO4900072 A1 CO 4900072A1 CO 97054843 A CO97054843 A CO 97054843A CO 97054843 A CO97054843 A CO 97054843A CO 4900072 A1 CO4900072 A1 CO 4900072A1
- Authority
- CO
- Colombia
- Prior art keywords
- lower alkyl
- hydrogen
- cycloalkyl
- alkenyl
- aralkyl
- Prior art date
Links
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- PPNXXZIBFHTHDM-UHFFFAOYSA-N aluminium phosphide Chemical compound P#[Al] PPNXXZIBFHTHDM-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de 1-carba-(detia)-cefalosporina, de fórmula general Ien dondeR1 es hidrógeno, alquilo inferior opcionalmente substituido con flúor, aralquilo, cicloalquilo, -COR4 ó -C(R5 R6 )CO2 R7 -C(R5 R6 )CONHR7 ; en donde R5 y R6 son cada uno independientemente entre sí, hidrógeno o alquilo inferior, ó R5 y R6 tomados conjuntamente forman un grupo cicloalquilo; R4 es hidrógeno o alquilo inferior y R7 es hidrógeno, alquilo inferior, alquenilo inferior o un grupo protector de ácido carboxílico; es hidrógeno, hidroxilo, Qm -alquilo inferior, cicloalquilo, alcoxilo inferior, alquenilo inferior, Qm -aralquilo, Qm -arilo, ariloxilo, aralcoxilo, un anillo heterocíclico o heterocíclilo alquilo inferior, alquilo inferior, cicloalquilo, alcoxilo inferior, alquenilo inferior, cicloalquenilo, alquinilo inferior, aralquilo, arilo, ariloxilo, aralcoxilo estando el anillo heterocíclico sin substituir o substituido con por lo menos un grupo seleccionado entre carboxilo, amino, nitro, ciano, alquilo inferior opcionalmente substituido con flúor, alcoxilo inferior, hidroxilo, halógeno, -COR6 , -C(R5 R6 )CO2 R7 , -C(R5 R6 )CONR5 R8 , -CONR5 R6 , N(R6 )COOR10 , R6 OCO- ó R6 COO-, en donde R5 y R6 son hidrógeno o alquilo inferior; R7 es hidrógeno, alquilo inferior, alquenilo inferior o un grupo protector de ácido carboxílico; R8 es hidrógeno, alquilo inferior o fenilo opcionalmente substituido; R10 es alquilo inferior, alquenilo inferior o un grupo de protección de ácido carboxílico; Q es -CHR-, -CO- ó -SO2 -; R es hidrógeno o alquilo inferior R3 es hidroxilo, -O-, alcoxilo inferior, -OM y M representan un metal alcalino; m es O ó 1;n es 0, 1 ó 2; X es CH ó N así como ésteres de los mismos fácilmente hidrolizables, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de fórmula I de sus ésteres y sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96115210 | 1996-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900072A1 true CO4900072A1 (es) | 2000-03-27 |
Family
ID=8223209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97054843A CO4900072A1 (es) | 1996-09-23 | 1997-09-19 | Derivados de 1-carba-(detia)-cefalosporina |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5939410A (es) |
| JP (1) | JPH10101670A (es) |
| KR (1) | KR100256473B1 (es) |
| CN (1) | CN1184110A (es) |
| AR (1) | AR008450A1 (es) |
| AU (1) | AU723176B2 (es) |
| BR (1) | BR9704770A (es) |
| CA (1) | CA2216222A1 (es) |
| CO (1) | CO4900072A1 (es) |
| CZ (1) | CZ292097A3 (es) |
| HR (1) | HRP970511A2 (es) |
| HU (1) | HUP9701548A3 (es) |
| ID (1) | ID18323A (es) |
| IL (1) | IL121798A0 (es) |
| MA (1) | MA26442A1 (es) |
| NO (1) | NO974366L (es) |
| NZ (1) | NZ328595A (es) |
| PE (1) | PE110098A1 (es) |
| PL (1) | PL322240A1 (es) |
| SG (1) | SG53049A1 (es) |
| TR (1) | TR199701011A2 (es) |
| YU (1) | YU38497A (es) |
| ZA (1) | ZA978332B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008316688A1 (en) * | 2007-10-25 | 2009-04-30 | Achaogen, Inc. | Carbacephem beta-lactam antibiotics |
| WO2010030810A1 (en) * | 2008-09-10 | 2010-03-18 | Achaogen, Inc. | Carbacephem beta-lactam antibiotics |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0112481A1 (en) * | 1982-11-12 | 1984-07-04 | Kyowa Hakko Kogyo Co., Ltd | Beta-lactam compound |
| GB9213567D0 (en) * | 1992-06-26 | 1992-08-12 | Smithkline Beecham Plc | Novel compounds |
| ATE227728T1 (de) * | 1993-04-16 | 2002-11-15 | Basilea Pharmaceutica Ag | Cephalosporin-derivate |
| CN1176641A (zh) * | 1995-02-27 | 1998-03-18 | 弗·哈夫曼-拉罗切有限公司 | 3－吡咯烷亚基－2－酮－头孢菌素衍生物 |
| EP0761673A1 (en) * | 1995-09-12 | 1997-03-12 | F. Hoffmann-La Roche Ag | Cephalosporin derivatives |
-
1997
- 1997-08-22 SG SG1997003018A patent/SG53049A1/en unknown
- 1997-09-09 NZ NZ328595A patent/NZ328595A/xx unknown
- 1997-09-10 US US08/929,248 patent/US5939410A/en not_active Expired - Fee Related
- 1997-09-16 ZA ZA9708332A patent/ZA978332B/xx unknown
- 1997-09-17 HU HU9701548A patent/HUP9701548A3/hu unknown
- 1997-09-17 CZ CZ972920A patent/CZ292097A3/cs unknown
- 1997-09-18 IL IL12179897A patent/IL121798A0/xx unknown
- 1997-09-18 YU YU38497A patent/YU38497A/sh unknown
- 1997-09-19 CA CA002216222A patent/CA2216222A1/en not_active Abandoned
- 1997-09-19 JP JP9254596A patent/JPH10101670A/ja active Pending
- 1997-09-19 AU AU38382/97A patent/AU723176B2/en not_active Ceased
- 1997-09-19 PE PE1997000839A patent/PE110098A1/es not_active Application Discontinuation
- 1997-09-19 CO CO97054843A patent/CO4900072A1/es unknown
- 1997-09-19 AR ARP970104305A patent/AR008450A1/es not_active Application Discontinuation
- 1997-09-22 NO NO974366A patent/NO974366L/no not_active Application Discontinuation
- 1997-09-22 HR HR96115210.5A patent/HRP970511A2/hr not_active Application Discontinuation
- 1997-09-22 BR BR9704770A patent/BR9704770A/pt unknown
- 1997-09-22 CN CN97119529A patent/CN1184110A/zh active Pending
- 1997-09-22 PL PL97322240A patent/PL322240A1/xx unknown
- 1997-09-23 ID IDP973266A patent/ID18323A/id unknown
- 1997-09-23 MA MA24807A patent/MA26442A1/fr unknown
- 1997-09-23 TR TR97/01011A patent/TR199701011A2/xx unknown
- 1997-09-23 KR KR1019970048181A patent/KR100256473B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA978332B (en) | 1998-03-23 |
| PE110098A1 (es) | 1999-01-13 |
| HUP9701548A2 (hu) | 1999-05-28 |
| CA2216222A1 (en) | 1998-03-23 |
| KR100256473B1 (ko) | 2000-05-15 |
| MX9707201A (es) | 1998-06-28 |
| KR19980024863A (ko) | 1998-07-06 |
| CN1184110A (zh) | 1998-06-10 |
| NZ328595A (en) | 1999-01-28 |
| BR9704770A (pt) | 1998-11-03 |
| YU38497A (sh) | 1999-12-27 |
| HU9701548D0 (en) | 1997-11-28 |
| AR008450A1 (es) | 2000-01-19 |
| CZ292097A3 (cs) | 1998-04-15 |
| MA26442A1 (fr) | 2004-12-20 |
| US5939410A (en) | 1999-08-17 |
| SG53049A1 (en) | 1998-09-28 |
| AU3838297A (en) | 1998-01-15 |
| PL322240A1 (en) | 1998-03-30 |
| NO974366D0 (no) | 1997-09-22 |
| HRP970511A2 (en) | 1998-08-31 |
| HUP9701548A3 (en) | 2001-04-28 |
| IL121798A0 (en) | 1998-02-22 |
| TR199701011A2 (xx) | 1998-04-21 |
| AU723176B2 (en) | 2000-08-17 |
| NO974366L (no) | 1998-03-24 |
| JPH10101670A (ja) | 1998-04-21 |
| ID18323A (id) | 1998-03-26 |
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