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CO4900040A1 - Nuevos derivados de acidos alfa-hidroxi su preparacion y aplicacion - Google Patents

Nuevos derivados de acidos alfa-hidroxi su preparacion y aplicacion

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Publication number
CO4900040A1
CO4900040A1 CO97018892A CO97018892A CO4900040A1 CO 4900040 A1 CO4900040 A1 CO 4900040A1 CO 97018892 A CO97018892 A CO 97018892A CO 97018892 A CO97018892 A CO 97018892A CO 4900040 A1 CO4900040 A1 CO 4900040A1
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Colombia
Prior art keywords
alkyl
alkoxy
alkylthio
phenyl
halogen
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CO97018892A
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English (en)
Inventor
Dagmar Klinge
Wilhelm Amberg
Ernst Baumann
Andreas Kling
Hartmut Riechers
Liliane Unger
Manfred Raschack
Sabine Schult
Original Assignee
Basf Ag
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Application filed by Basf Ag filed Critical Basf Ag
Publication of CO4900040A1 publication Critical patent/CO4900040A1/es

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    • C07D251/20—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with no nitrogen atoms directly attached to a ring carbon atom
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Abstract

Derivados de ácidos alfa-hidroxicarboxílicos de la fórmula Ien el cual R es un grupoen el cual R1 tiene el siguiente significado: a) Hidrógeno b) un grupo succinilimido c) un heteroaromato de 5 miembros ligado mediante un átomo de nitrógeno, como pirrolilo, pirazolilo, imirazolilo y triazolilo, el cual puede tener uno hasta dos átomos halógenos o uno hasta dos grupos C1 -C4 -alquilo o uno hasta dos grupos C1 -C4 -alcoxi; d) un grupo donde k asume los valores 0, 1 y 2, p los valores 1, 2, 3 y 4 y R9 representaC1 -C4 -alquilo, C3 -C7 -cicloalquilo, C3 -C6 - alquenilo, C3 -C6 -alquinilo o fenilo eventualmente sustituido, el cual puede estar sustituido por uno o varios de los siguientes radicales: halógeno, nitro, ciano, C1 -C4 -alquilo, C1 -C4 -halogenoalquilo, hidroxi, C1 -C4 -alcoxi, - 2 -C1 -C4 -alquiltio, mercapto, amino, C1 -C4 -alquilamino, C1 -C4 -dialquilamino; e) R1 además un radical OR10 , en el cual R10 significa: hidrógeno, el catión de un metal alcalino como litio, sodio, potasio o el catión de un metal alcalino térreo como calcio, magnesio y bario así como un ión alquilamónico fisiológicamente compatible o el ión amónico; C3 -C8 -cicloalquilo, C1 -C8 -alquilo, CH2 -fenilo que puede estar sustituido por uno o varios de los siguientes radicales: halógeno, nitro, ciano, C1 -C4 -alquilo, C1 -C4 -halogenalquilo, hidroxi, C1 -C4 -alcoxi, mercapto, C1 -C4 -alquiltio, amino, C1 -C4 -alquilamino, C1 -C4 -dialquilamino, Un grupo C3 -C6 -alquenilo o C3 -C6 -alquinilo, pudiendo este grupo tener a su vez uno hasta cinco átomos de halógeno; R10 puede ser además un radical fenilo, el cual puede tener uno hasta cinco átomos de halógeno y/o uno hasta tres de los siguientes radicales: nitro, ciano, C1 -C4 -alquilo, C1 -C4 -halogenalquilo, hidroxi, C1 -C4 -alcoxi, mercapto, C1 -C4 -alquiltio, amino, C1 -C4 -alquilamino, C1 -C4 -dialquilamino; Un heteroaromato de 5 miembros ligado mediante un átomo de nitrógeno que contiene uno a tres átomos de nitrógeno, el cual puede tener uno hasta dos átomos halógenos y/o uno hasta dos de los siguientes radicales: C1 -C4 -alquilo, C1 -C4 -halogenalquilo, C1 -C4 -alcoxi, fenilo, C1 -C4 -halogenalcoxi y/o C1 -C4 -alquiltio. f) R1 además un radicalen el cual R11 significa: C1 -C4 -alquilo, C3 -C6 -alquenilo, C3 -C6 -alquinilo, C3 -C8 -cicloalquilo, pudiendo estos radicales tener un radical C1 -C4 -alcoxi, C1 -C4 -alquiltio y/o fenilo, como se mencionó antes: fenilo, eventualmente sustituido; g) R1 un radical en el cual R12 tiene el mismo significado como R11 ; h) además R1 puede significar pudiendo R13 y R14 ser iguales o diferentes y tener el siguiente significado: hidrógeno, C1 AND#8209;C7 AND#8209;alquilo, C3 AND#8209;C7 AND#8209;cicloalquilo, C3 AND#8209;C7 AND#8209;alquenilo, C3 AND#8209;C7 AND#8209;alquinilo, bencilo, fenilo, eventualmente sustituido,o R13 y R14 forman juntos una cadena C4 AND#8209;C7 AND#8209;alquileno, cerrada en forma de anillo, opcionalmente sustituida, por ejemplo, por C1 AND#8209;C4 AND#8209;alquilo, la cual puede tener un heteroátomo o R un tetrazol o un nitrilo W Nitrógeno, CAND#8209;NO2 , un grupo CH, cuando uno o varios de los sustituyentes R2 , R3 , R15 y/o R16 significan un grupo nitro o cuando X y/o Y significan nitrógeno; R2 Hidrógeno, halógeno, C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenoalcoxi, hidroxi, mercapto, C1 AND#8209;C4 AND#8209;alquiltio, nitro, amino, C1 AND#8209;C4 AND#8209;alquilamino o C1 AND#8209;C4 AND#8209;dialquilamino, ciano, fenilo, opcionalmente sustituido una hasta tres veces con halógeno, hidroxi, amino, mono o dialquil (C1 AND#8209;C3 )AND#8209;amino, C1 AND#8209;C3 AND#8209;alquilo, C1 AND#8209;C3 AND#8209;alcoxi, mercapto o C1 AND#8209;C3 AND#8209; alquiltio, carboxilo, C1 AND#8209;C3 AND#8209;alquilcarboxilo; un heteroaromato de cinco o seis miembros que contiene uno hasta tres átomos de nitrógeno y/o un átomo de azufre o de oxígeno. Además R2 puede formar con los átomos de carbono vecinos y X un anillo alquileno o alquilideno de 5 a 6 miembros en el cual respectivamente uno o dos átomos de carbono pueden estar reemplazado por un heteroátomo como nitrógeno, azufre u oxígeno y que puede estar uno hasta tres veces sustituido por los siguientes radicales: halógeno, nitro, ciano, hidroxi, mercapto, C1 AND#8209;C3 AND#8209; alquilo, C1 AND#8209;C3 AND#8209;halogenalquilo, C1 AND#8209;C3 AND#8209;alcoxi, C1 AND#8209;C3 AND#8209;alquiltio, amino, C1 AND#8209;C3 AND#8209;alquilamino, C1 AND#8209;C3 AND#8209;dialquilamino; X Significa nitrógeno o CR15 , donde R15 puede ser hidrógeno o C1 AND#8209;C5 AND#8209;alquilo, opcionalmente sustituido uno hasta dos veces con hidroxi o carboxi; C1 AND#8209;C6 AND#8209; alcoxi, C1 AND#8209;C6 AND#8209;alquiltio, fenilo, bencilo, hidroxi, mercapto, nitro, amino, C1 AND#8209;C4 AND#8209;alquilamino, C1 AND#8209;C4 AND#8209;dialquilamino, ciano o carboxi; además CR15 puede estar unido con R2 en un anillo de 5 o 6 miembros, o CR15 puede con R3 y su átomo de carbono vecino formar un anillo alquileno o alquilideno de 5 o 6 miembros, en el cual respectivamente uno o dos átomos de carbono pueden estar remplazados por nitrógeno, oxígeno o azufre, el anillo de 5 o 6 miembros puede opcionalmente estar sustituido una hasta tres veces con los siguientes radicales: Halógeno, nitro, ciano, hidroxi, mercapto, C1 AND#8209;C3 AND#8209;alquilo, C1 AND#8209;C3 AND#8209;halogenalquilo, C1 AND#8209;C3 AND#8209;alcoxi, C1 AND#8209;C3 AND#8209;alquiltio, amino, C1 AND#8209;C3 AND#8209;alquilamino, C1 AND#8209;C3 AND#8209;dialquilamino o carboxi; el nitrógeno en el anillo 5 también puede estar sustituido por un grupo formilo o acetilo; R3 puede tener el mismo significado como R2 , R2 y R3 pueden ser iguales o diferentes; además R puede formar con el átomo de carbono vecino y con X un anillo de 5 o 6 miembros; además R3 puede formar con el átomo de carbono vecino y Y un anillo alquileno o alquilideno de 5 o 6 miembros en el cual respectivamente uno o dos átomos de carbono pueden estar reemplazados por nitrógeno, oxígeno o azufre; el anillo de 5 o 6 miembros puede opcionalmente estar sustituido una hasta tres veces con los siguientes radicales: Halógeno, nitro, ciano, hidroxi, mercapto, C1 AND#8209;C3 AND#8209;alquilo, C1 AND#8209;C3 AND#8209;halogenalquilo, C1 AND#8209;C3 AND#8209;alcoxi, C1 AND#8209;C3 AND#8209;alquiltio, amino, C1 AND#8209;C3 AND#8209;alquilamino, C1 AND#8209;C3 AND#8209;dialquilamino o carboxi; el nitrógeno en el anillo 5 puede estar sustituido también por un grupo o acetilo; Y Nitrógeno o CR16 , donde R16 significa hidrógeno, C1 AND#8209;C5 AND#8209;alquilo, C1 AND#8209;C5 AND#8209;alcoxi, C1 AND#8209;C5 AND#8209;alquiltio, nitro, fenilo, hidroxi, halógeno, ciano, amino, C1 AND#8209;C4 AND#8209;alquilamino, C1 AND#8209;C4 AND#8209;dialquilamino, mercapto o carboxi o CR16 junto con R3 y su átomo vecino de carbono forman un anillo de 5 o 6 miembros; R4 es fenilo, naftilo, dihidro o tetrahidronaftilo, el cual puede estar sustituido por uno o varios de los siguientes radicales: Halógeno, nitro, ciano, hidroxi, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenalcoxi, fenoxi, fenilo, C1 AND#8209;C4 AND#8209; alquiltio, amino, C1 AND#8209;C4 AND#8209;alquilamino o C1 AND#8209;C4 AND#8209; dialquilamino, pudiendo formar dos radicales en átomos de carbono vecinos junto con estos un anillo de 5 o 6 miembros unido a través de un grupo alquileno o alquilideno, en el cual uno o varios grupos metileno o metilideno pueden estar reemplazados por oxígeno; R5 puede tener el mismo significado que R4 pudiendo R4 y R5 ser iguales o diferentes; R6 Significa hidrógeno, C1 AND#8209;C8 AND#8209;alquilo, C2 AND#8209;C8 AND#8209; alquenilo o C3 AND#8209;C8 AND#8209;alquinilo, pudiendo estos radicales respectivamente estar sustituidos una o varias veces por: halógeno, nitro, ciano, C1 AND#8209;C4 AND#8209; alcoxi, hidroxi, C1 AND#8209;C4 AND#8209;alquiltio, mercapto, C1 AND#8209;C4 AND#8209; halogenalcoxi, carboxi, C1 AND#8209;C4 AND#8209;alquilcarboxi, C1 AND#8209;C4 AND#8209;alquilcarbonilo, amino, C1 AND#8209;C4 AND#8209;alquilamino, C1 AND#8209;C4 AND#8209;dialquilamino, fenilo o naftilo el cual a su vez puede estar sustituido uno o varias veces por: halógeno, nitro, ciano, hidroxi, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AND#8209; halogenalcoxi, mercapto, C1 AND#8209;C4 AND#8209;alquiltio, amino, C1 AND#8209;C4 AND#8209;alquilamino, C1 AND#8209;C4 AND#8209;dialquilamino o fenoxi. Además R6 significa C1 AND#8209;C4 AND#8209;alquilo, que está sustituido por fenilmetoxi o fenoxi en el cual el grupo fenilo puede estar sustituido una o dos veces por halógeno, metilo o metoxi; Además R6 significa también una cadena C1 AND#8209;C8 AND#8209; alquilo, C3 AND#8209;C8 AND#8209;alquenilo o C3 AND#8209;C8 AND#8209;alquinilo que está sustituida por uno de los siguientes radicales:Heteroarilo o heteroariloxi, de 5 o 6 miembros, que contiene uno hasta tres átomos de nitrógeno y/o un átomode azufre o de oxígeno, el cual puede tener unohasta cuatro átomos halógenos y/o uno hasta dos de losiguientes radicales:C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenalcoxi, C1 AND#8209;C4 AND#8209;alquiltio, fenilo, fenoxi o fenilcarbonilo, pudiendo los radicales de fenilo a su vez contener uno hasta cinco átomos halógenos y/o uno hasta tres de los siguientes radicales: C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenalcoxi y/o C1 AND#8209;C4 AND#8209; alquiltio; Fenilo, naftilo que a su vez puede estar sustituido una o varias veces por: halógeno, nitro, ciano, hidroxi, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AN
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TR199901416T2 (xx) 1996-12-18 1999-08-23 Basf Aktiengesellschaft Heterosiklik karbonikasit t�revleri.
US6030975A (en) * 1997-03-14 2000-02-29 Basf Aktiengesellschaft Carboxylic acid derivatives, their preparation and use in treating cancer
DE19726146A1 (de) * 1997-06-19 1998-12-24 Basf Ag Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
SK179899A3 (en) 1997-07-03 2001-12-03 Du Pont Pharm Co Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
DE19743681A1 (de) * 1997-10-02 1999-04-08 Knoll Ag Methode zur Verhinderung der Transplantatabstoßung
AU742506B2 (en) 1997-10-17 2002-01-03 Eurogene Limited The use of inhibitors of the renin-angiotensin system
DE19806438A1 (de) * 1998-02-17 1999-08-19 Basf Ag Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
PT1243262E (pt) 2001-03-20 2006-10-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica
DK1243263T3 (da) 2001-03-21 2003-03-17 Sanol Arznei Schwarz Gmbh Hidtil ukendt anvendelse af en klasse af peptidforbindelser til behandling af allodyni eller andre forskellige typer af kronisk- eller fantomsmerte
CN1950101B (zh) 2004-04-16 2011-03-30 舒沃茨药物股份公司 肽化合物用于预防和治疗慢性头痛的用途
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
KR20070045271A (ko) 2004-08-27 2007-05-02 쉬바르츠파르마에이지 골암 통증, 화학요법- 및 뉴클레오시드- 유도 통증의치료를 위한 펩티드 화합물의 용도
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EP2992891B1 (en) 2006-06-15 2020-08-05 UCB Pharma GmbH Pharmaceutical composition comprising brivaracetam and lacosamide with synergistic anticonvulsant effect
WO2011022694A2 (en) * 2009-08-20 2011-02-24 University Of Tennessee Research Foundation, The Furanopyrimidine cannabinoid compounds and related methods of use

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DE4411225A1 (de) 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
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