CO4650045A1 - Alquilacion reductiva de antibioticos glicopeptidos - Google Patents
Alquilacion reductiva de antibioticos glicopeptidosInfo
- Publication number
- CO4650045A1 CO4650045A1 CO97067572A CO97067572A CO4650045A1 CO 4650045 A1 CO4650045 A1 CO 4650045A1 CO 97067572 A CO97067572 A CO 97067572A CO 97067572 A CO97067572 A CO 97067572A CO 4650045 A1 CO4650045 A1 CO 4650045A1
- Authority
- CO
- Colombia
- Prior art keywords
- glycopeptide
- antibiotic
- reductive
- amine
- rental
- Prior art date
Links
- 102000002068 Glycopeptides Human genes 0.000 title abstract 3
- 108010015899 Glycopeptides Proteins 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 230000002829 reductive effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 7
- 239000003910 polypeptide antibiotic agent Substances 0.000 abstract 4
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000004699 copper complex Chemical class 0.000 abstract 3
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001299 aldehydes Chemical class 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- UXCMNUUPBMYDLJ-UHFFFAOYSA-N 4-(4-chlorophenyl)benzaldehyde Chemical group C1=CC(Cl)=CC=C1C1=CC=C(C=O)C=C1 UXCMNUUPBMYDLJ-UHFFFAOYSA-N 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910000085 borane Inorganic materials 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005932 reductive alkylation reaction Methods 0.000 abstract 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un método para la alquilación reductiva de un antibióticoglicopéptido que comprende un sacárido que contiene amina en la posición N4 y uno ó más grupos amina, método que comprende la reacción de un complejo de cobre del antibiótico glicopéptido con un aldehído o una cetona en presencia de un agente reductor el cual puede tratarse de cianoborohidruro de sodio ó del complejo piridina.borano.Un método acorde con la reivindicación 1 el cual es llevado a cabo en metanol.Un método acorde con la reivindicación 2 en el cual el complejo de cobre soluble del antibiótico glicopéptido se preparar "in situ" a partir del antibiótico glicopeptido y una forma soluble de cobre.Un método acorde con la Reivindicación 5 en donde el aldehido es el 4´-cloro-4-bifenilcarboxaldehido.1Un método para la preparación de un antibiótico glicopéptido el cual se encuentra alquilado en un sacárido que contiene amina en la posición N4 , método que comprende el tratamiento acuoso de un complejo de cobre de dicho antibiótico glicopéptido a un pHANDlt; 4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3159696P | 1996-11-21 | 1996-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4650045A1 true CO4650045A1 (es) | 1998-09-03 |
Family
ID=21860369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97067572A CO4650045A1 (es) | 1996-11-21 | 1997-11-19 | Alquilacion reductiva de antibioticos glicopeptidos |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0845478B1 (es) |
| JP (1) | JP4308912B2 (es) |
| KR (1) | KR100514276B1 (es) |
| CN (1) | CN100463917C (es) |
| AR (1) | AR010621A1 (es) |
| AT (1) | ATE286910T1 (es) |
| AU (1) | AU723941B2 (es) |
| BR (1) | BR9713523B1 (es) |
| CA (1) | CA2272240C (es) |
| CO (1) | CO4650045A1 (es) |
| CZ (1) | CZ300528B6 (es) |
| DE (1) | DE69732215T2 (es) |
| EA (1) | EA002925B1 (es) |
| EG (1) | EG23855A (es) |
| HU (1) | HU227641B1 (es) |
| ID (1) | ID18900A (es) |
| IL (1) | IL129991A0 (es) |
| MY (1) | MY117383A (es) |
| NO (1) | NO325365B1 (es) |
| NZ (1) | NZ335840A (es) |
| PE (1) | PE17499A1 (es) |
| PL (1) | PL190780B1 (es) |
| TR (1) | TR199901679T2 (es) |
| TW (1) | TW585868B (es) |
| UA (1) | UA58526C2 (es) |
| WO (1) | WO1998022121A1 (es) |
| ZA (1) | ZA9710428B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60135102D1 (de) * | 2000-05-02 | 2008-09-11 | Theravance Inc | Verfahren zur reduktiven alkylierung von glykopeptiden |
| MX388561B (es) | 2013-03-15 | 2025-03-11 | Melinta Subsidiary Corp | Metodos para tratar infecciones en pacientes obesos y con sobrepeso usando antibioticos. |
| HRP20250212T1 (hr) * | 2014-07-17 | 2025-04-11 | Melinta Therapeutics, Llc | Oritavancin visoke čistoće i način proizvodnje istog |
| CN106188243B (zh) * | 2015-05-05 | 2020-06-26 | 博瑞生物医药（苏州）股份有限公司 | 一种奥利万星的制备方法 |
| CN106467570B (zh) * | 2015-08-14 | 2020-04-07 | 正大天晴药业集团股份有限公司 | 糖肽类抗生素的还原烷基化方法 |
| CN108409837B (zh) * | 2018-03-06 | 2021-09-24 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4051237A (en) * | 1975-08-28 | 1977-09-27 | Bristol-Myers Company | Glycopeptide antibiotics bu-2231 a and b and process for producing same |
| JPS58116497A (ja) * | 1981-12-29 | 1983-07-11 | Microbial Chem Res Found | アミノプロピルアミノブレオマイシン誘導体及びその製造法 |
| US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| CA2031803C (en) * | 1989-12-13 | 2001-05-29 | Ramakrishnan Nagarajan | Improvements in or relating to glycopeptide deriveratives |
| AU703106B2 (en) * | 1994-01-28 | 1999-03-18 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
-
1997
- 1997-11-13 ID IDP973669A patent/ID18900A/id unknown
- 1997-11-19 MY MYPI97005545A patent/MY117383A/en unknown
- 1997-11-19 DE DE69732215T patent/DE69732215T2/de not_active Expired - Lifetime
- 1997-11-19 PE PE1997001054A patent/PE17499A1/es not_active Application Discontinuation
- 1997-11-19 AR ARP970105411A patent/AR010621A1/es active IP Right Grant
- 1997-11-19 EG EG123597A patent/EG23855A/xx active
- 1997-11-19 AT AT97309305T patent/ATE286910T1/de not_active IP Right Cessation
- 1997-11-19 EP EP97309305A patent/EP0845478B1/en not_active Expired - Lifetime
- 1997-11-19 CO CO97067572A patent/CO4650045A1/es unknown
- 1997-11-19 ZA ZA9710428A patent/ZA9710428B/xx unknown
- 1997-11-20 EA EA199900480A patent/EA002925B1/ru not_active IP Right Cessation
- 1997-11-20 NZ NZ335840A patent/NZ335840A/xx not_active IP Right Cessation
- 1997-11-20 CN CNB971813701A patent/CN100463917C/zh not_active Expired - Fee Related
- 1997-11-20 IL IL12999197A patent/IL129991A0/xx not_active IP Right Cessation
- 1997-11-20 BR BRPI9713523-2A patent/BR9713523B1/pt not_active IP Right Cessation
- 1997-11-20 CA CA2272240A patent/CA2272240C/en not_active Expired - Fee Related
- 1997-11-20 HU HU0000268A patent/HU227641B1/hu not_active IP Right Cessation
- 1997-11-20 KR KR10-1999-7004441A patent/KR100514276B1/ko not_active Expired - Lifetime
- 1997-11-20 UA UA99052810A patent/UA58526C2/uk unknown
- 1997-11-20 WO PCT/US1997/021238 patent/WO1998022121A1/en not_active Ceased
- 1997-11-20 CZ CZ0179499A patent/CZ300528B6/cs not_active IP Right Cessation
- 1997-11-20 JP JP52387898A patent/JP4308912B2/ja not_active Expired - Fee Related
- 1997-11-20 PL PL333778A patent/PL190780B1/pl unknown
- 1997-11-20 TR TR1999/01679T patent/TR199901679T2/xx unknown
- 1997-11-20 AU AU54497/98A patent/AU723941B2/en not_active Ceased
- 1997-11-22 TW TW086117372A patent/TW585868B/zh not_active IP Right Cessation
-
1999
- 1999-05-20 NO NO19992415A patent/NO325365B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8704352A1 (es) | Procedimiento para preparar complejos magneticos fisiologicamente compatibles a base de un oxido-hidroxido metalico doble | |
| DE59008007D1 (de) | Elektromagnetisch betätigtes Ventil, insbes. für Antiblockiersysteme in Kraftfahrzeugen. | |
| DE59103114D1 (de) | Hydraulische Bremsanlage, insbesondere für Kraftfahrzeuge. | |
| BR0006861A (pt) | Processo de possibilitar que uma primeira rede doméstica de uma primeira arquitetura de software interaja com uma segunda rede doméstica de uma segunda arquitetura de software, sistema de processamento de informações, e, componente de software para uso em um sistema de ambiente doméstico | |
| AR023675A1 (es) | Un material soluble en agua o dispersable en agua para su deposicion sobre un sustrato de tela durante un proceso de lavado y/o enjuague y/o secado, un metodo para depositar un agente de beneficio sobre un sustrato de tela y una composicion que comprende al material | |
| DE59602828D1 (de) | Koaxialer steckverbinder für die kommunikationstechnik insbesondere in fahrzeugen | |
| DE59003746D1 (de) | Bremszylinder für Fahrzeuge, insbesondere Schienenfahrzeuge. | |
| DE60225174D1 (de) | Beta-3 adrenergische agonisten | |
| BR9508823A (pt) | Sistema de centralização com uma válvula de uma via para máquina com pistão livre | |
| AR020542A1 (es) | UN MATERIAL HIDROSOLUBLE O DISPERSABLE EN AGUA, UN MÉTODO PARA DEPOSITAR UN AGENTE DE BENEFICIO SOBRE UN SUSTRATO USANDO DICHO MATERIAL Y UNA COMPOSICIoN QUE COMPRENDE A DICHO MATERIAL. | |
| DE59006839D1 (de) | Ventil, insbesondere für schlupfgeregelte hydraulische bremsanlagen. | |
| CO4650045A1 (es) | Alquilacion reductiva de antibioticos glicopeptidos | |
| ES2179012T3 (es) | Conector de enchufe electrico. | |
| DE59106298D1 (de) | Schwimmerventil für füllanlagen, insbesondere zum füllen von elektrischen traktionsbatterien. | |
| ES2008087B3 (es) | Montaje de tope de desembrague reversible, en especial para vehiculo automovil. | |
| CA2375040A1 (en) | Orally active a1 adenosine receptor agonists | |
| CO4970704A1 (es) | Solucion acuosa estable de em 12, y procedimiento de preparacion de dicha solucion | |
| ES2185350T3 (es) | Sintesis de morfina-6-glucuronido. | |
| ATE125324T1 (de) | Spülklosettanlage, insbesondere für fahrzeuge. | |
| DE59005031D1 (de) | Ventildrossel, insbesondere für hochspannungs-gleichstrom-übertragungsanlagen. | |
| IT9048407A0 (it) | Procedimento di regolazione antibloccaggio e sistema antibloccaggio per la esecuzione del procedimento, in particolare per veicoli da altavelocita'. | |
| DE59608268D1 (de) | Trennmittel für die dc-ftir-kopplung | |
| IT9067149A0 (it) | Sistema di distribuzione, in particolare per un motore endotermico a piu' valvole per cilindro. | |
| EP0091740A3 (en) | A composition and process for treating hair | |
| AR002291A1 (es) | Procedimiento para la preparacion de derivados de estreptograminas y dichos derivados asi obtenidos. |