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CO2017010583A2 - Compuestos de pirazol y método para elaborar y usar los compuestos - Google Patents

Compuestos de pirazol y método para elaborar y usar los compuestos

Info

Publication number
CO2017010583A2
CO2017010583A2 CONC2017/0010583A CO2017010583A CO2017010583A2 CO 2017010583 A2 CO2017010583 A2 CO 2017010583A2 CO 2017010583 A CO2017010583 A CO 2017010583A CO 2017010583 A2 CO2017010583 A2 CO 2017010583A2
Authority
CO
Colombia
Prior art keywords
compounds
making
compositions
pyrazole
disclosed
Prior art date
Application number
CONC2017/0010583A
Other languages
English (en)
Inventor
Rajinder Singh
Ryan Kelley
Hui Li
Thilo Heckrodt
Yan Chen
Darren Mcmurtrie
Kin Tso
Vanessa Taylor
Rose Yen
Jack Maung
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of CO2017010583A2 publication Critical patent/CO2017010583A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

RESUMEN COMPUESTOS DE PIRAZOL Y MÉTODO PARA ELABORAR Y USAR LOS COMPUESTOS Las realizaciones divulgadas tratan de inhibidores de cinasas asociadas con receptores de interleucina (IRAK) y composiciones que comprenden estos inhibidores. También se divulgan métodos para elaborar y usar los compuestos y las composiciones. Los compuestos y/o las composiciones divulgados se pueden usar para tratar o prevenir una enfermedad o afección asociada con IRAK.
CONC2017/0010583A 2015-04-22 2017-10-17 Compuestos de pirazol y método para elaborar y usar los compuestos CO2017010583A2 (es)

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Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201506872D0 (en) 2015-04-22 2015-06-03 Ge Oil & Gas Uk Ltd Novel compounds
MX380940B (es) * 2015-04-22 2025-03-11 Rigel Pharmaceuticals Inc Compuestos de pirazol y metodo para elaborar y usar los compuestos.
WO2018081294A1 (en) 2016-10-26 2018-05-03 Rigel Pharmaceuticals, Inc. Pyrazole amide compounds as irak inhibitors
PT3532470T (pt) 2016-10-26 2023-02-28 Rigel Pharmaceuticals Inc Derivados de oxazol para uso como inibidores de irak e método para a sua preparação
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
EP3645525A1 (en) * 2017-06-29 2020-05-06 Rigel Pharmaceuticals, Inc. Kinase inhibitors and methods for making and using
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
MX2020003190A (es) 2017-09-22 2020-11-11 Kymera Therapeutics Inc Degradadores de proteinas y usos de los mismos.
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
CN107987063A (zh) * 2017-12-31 2018-05-04 窦玉玲 一种hsp90抑制剂及其在抗肿瘤药物的应用
CN107857758B (zh) * 2017-12-31 2018-08-24 广东莱恩医药研究院有限公司 一种酰胺类化合物及其作为hsp90抑制剂和抗肿瘤药物的应用
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
WO2019195810A2 (en) * 2018-04-06 2019-10-10 Praxis Biotech LLC Atf6 inhibitors and uses thereof
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
EP3817822A4 (en) 2018-07-06 2022-07-27 Kymera Therapeutics, Inc. PROTEIN DEGRADANTS AND USES THEREOF
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
WO2020028258A1 (en) 2018-07-31 2020-02-06 Loxo Oncology, Inc. Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide
CN110862375B (zh) * 2018-08-27 2022-10-25 深圳铂立健医药有限公司 吡唑化合物及其药物组合物和应用
EP3886904A4 (en) 2018-11-30 2022-07-13 Kymera Therapeutics, Inc. IRAQ DEGRADERS AND USES THEREOF
MX2022001596A (es) * 2019-08-08 2022-03-11 Rigel Pharmaceuticals Inc Compuestos y metodos para tratar sindrome de liberacion de citocinas.
AU2020335903A1 (en) 2019-08-30 2022-03-24 Rigel Pharmaceuticals, Inc. Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations
EP4076520A4 (en) 2019-12-17 2024-03-27 Kymera Therapeutics, Inc. Irak degraders and uses thereof
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
TW202241891A (zh) 2020-12-30 2022-11-01 美商凱麥拉醫療公司 Irak降解劑及其用途
CA3207049A1 (en) 2021-02-15 2022-08-18 Jared Gollob Irak4 degraders and uses thereof
US12357623B2 (en) 2021-03-03 2025-07-15 Rigel Pharmaceuticals, Inc. Method for treating a disease or condition using a pyrazole compound or formulation thereof
US20240174679A1 (en) * 2021-03-17 2024-05-30 Merck Sharp & Dohme Llc Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
JP2024519215A (ja) 2021-05-07 2024-05-09 カイメラ セラピューティクス， インコーポレイテッド Ｃｄｋ２分解剤およびそれらの使用
IL308683A (en) * 2021-06-01 2024-01-01 Realta Life Sciences Inc Peptides and methods of use
US20240382470A1 (en) * 2021-09-08 2024-11-21 Rigel Pharmaceuticals, Inc. Irak Inhibitor for Treating Cytokine Release-Related Conditions Associated With Infection by a Respiratory Virus
TW202334165A (zh) 2021-10-29 2023-09-01 美商凱麥拉醫療公司 Irak4降解劑及其製備
IL314437A (en) 2022-01-31 2024-09-01 Kymera Therapeutics Inc IRAK joints and their uses
JP2025513716A (ja) * 2022-03-23 2025-04-30 ライジェル・ファーマシューティカルズ・インコーポレイテッド Ｉｒａｋ阻害剤としてのピリミド－２－イル－ピラゾール化合物
WO2024011116A2 (en) * 2022-07-07 2024-01-11 Dana-Farber Cancer Institute, Inc. Potent and selective irreversible inhibitors of irak1
CN117209489B (zh) * 2023-05-30 2024-07-26 杭州邦顺制药有限公司 Irak激酶抑制剂
WO2025111251A1 (en) * 2023-11-20 2025-05-30 Exelixis, Inc. Compounds that inhibit polo-like kinase 4
CN121270516A (zh) * 2024-07-03 2026-01-06 科辉智药(深圳)新药研究中心有限公司 一种irak抑制剂化合物的晶型及其制备方法和应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037248A2 (en) * 2002-10-24 2004-05-06 Carex Sa Modulation of peroxisome proliferator activated receptors activity
TWI372050B (en) * 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
EP1836188A1 (en) * 2004-12-30 2007-09-26 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
WO2006070202A1 (en) * 2004-12-30 2006-07-06 Astex Therapeutics Limited Pyrazole derivatives having kinase modulating activity
DK2206707T3 (da) * 2007-10-24 2014-08-11 Astellas Pharma Inc Azolcarboxamidforbindelse eller salt deraf
EP2070925A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel
US8987309B2 (en) 2009-04-17 2015-03-24 The Translational Genomics Research Institute Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles
EP2243481A1 (en) 2009-04-24 2010-10-27 PamGene B.V. Irak kinase family as novel drug target for Alzheimer
WO2011043771A1 (en) 2009-10-07 2011-04-14 Nitto Denko Corporation Narrow band excitation light source for fluorescence sensing system
JP2012254939A (ja) * 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
JP6161537B2 (ja) * 2010-04-07 2017-07-12 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピラゾール−４−イル−ヘテロシクリル−カルボキサミド化合物及び使用の方法
KR20180099933A (ko) 2010-11-19 2018-09-05 리간드 파마슈티칼스 인코포레이티드 복소환 아민 및 이의 용도
CA2819378A1 (en) 2010-12-02 2012-06-07 Katholieke Universiteit Leuven, K.U.Leuven R&D Irak-related interventions and diagnosis
CA2822166C (en) 2010-12-20 2019-10-29 Merck Serono S.A. Indazolyl triazole derivatives as irak inhibitors
WO2012097013A1 (en) 2011-01-10 2012-07-19 Nimbus Iris, Inc. Irak inhibitors and uses thereof
EP2674423A4 (en) * 2011-02-09 2014-07-30 Nissan Chemical Ind Ltd PYRAZONE DERIVATIVE AND PESTICIDES
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
WO2013045461A1 (en) 2011-09-27 2013-04-04 F. Hoffmann-La Roche Ag Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
TW201728592A (zh) 2012-01-10 2017-08-16 林伯士艾瑞斯公司 Ｉｒａｋ抑制劑及其用途
US9328106B2 (en) * 2012-09-26 2016-05-03 Genentech, Inc. Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
WO2014058691A1 (en) * 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
CA2900431C (en) 2013-02-07 2021-05-04 Merck Patent Gmbh Pyridazinone-amides derivatives
WO2014121942A1 (en) 2013-02-07 2014-08-14 Merck Patent Gmbh Macrocyclic pyridazinone derivatives
US10314841B2 (en) 2014-01-09 2019-06-11 Merck Patent Gmbh Substituted pyrazoles as IRAK inhibitors
PL3221306T3 (pl) 2014-11-20 2020-09-07 Merck Patent Gmbh Związki heteroarylowe jako inhibitory irak i ich zastosowania
MX380940B (es) 2015-04-22 2025-03-11 Rigel Pharmaceuticals Inc Compuestos de pirazol y metodo para elaborar y usar los compuestos.
DK3331879T3 (da) * 2015-08-04 2020-08-10 Rigel Pharmaceuticals Inc Benzazolforbindelser og fremgangsmåder til fremstilling og anvendelse af forbindelserne

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