CN204814279U - Can dismantle rodent aerosol inhalation device - Google Patents

Abstract

The utility model relates to a detachable rodent atomization inhalation device, which is mainly composed of a top cover 1, an atomization chamber 3, an animal fixing device 6 and a spring plug 7 with holes. The device of the utility model is used for the positioning and atomization device required in the animal experiment process of the inhalation drug delivery system research. In the animal experimental research process of the inhalation drug delivery system, it can achieve the purpose of inhaling the mist droplets from the respiratory tract of rodents. All parts of the device can be disassembled to avoid cross-contamination when performing different experiments, and it is very convenient to clean. Different types of atomization devices can be connected to the inlet of atomized liquid medicine. Therefore, the device can also be used to evaluate the atomization efficiency of different types of atomizers on the market and their effects on different rodents.

Description

A detachable rodent aerosol inhalation device

technical field

The utility model relates to an atomization device, in particular to a rodent inhalation and administration atomization device for drug research.

Background technique

The respiratory tract is an important way for local and systemic delivery of drugs. Compared with oral administration, inhalation administration has the advantages of high therapeutic index, less side effects, high bioavailability, less drug dosage, and high delivery efficiency. Therefore, inhalation administration is also It has become an effective animal experiment method for evaluating drug efficacy and safety. Commonly used airtight transparent plastic spray chamber devices usually take rats and guinea pigs as the research objects. During the inhalation and drug administration test, it often appears that the animal’s whole body fur is attached to the drug. The research is more suitable for inhalation and drug administration experiments. Devices for animal experiments are necessary.

Contents of the invention

The purpose of the utility model is to provide an atomized drug delivery fixing device. The utility model purpose is achieved through the following technical solutions:

The utility model is mainly composed of a top cover 1, an atomization chamber 3, an animal fixing device 6 and a spring plug 7 with holes.

The top cover 1 has an atomized medicine liquid inlet 1a, and 1a is a cylindrical protrusion; 1a is a cylindrical protrusion; it can ensure that the catheter filled with the atomized liquid can be vertically inserted into the atomization chamber, and has a good fixing effect. There are 2-4 small air outlet holes 2 on the top cover 1, which are used to communicate with the outside world, so as to avoid insufficient oxygen in the cavity. There are 2-10 locking holes 4 on the top cover 1 for the integral connection of the top cover 1 and the atomization chamber 3, and the top cover can be removed for easy cleaning.

There are 2-10 lock holes 4 on the atomization chamber 3 for the integral connection of the top cover 1 and the atomization chamber 3; the atomization chamber 3 can have 1-3 layers; the 2-3 layers of atomization chambers pass through the lock holes 4 Integral connection; the atomizing chamber 3 has an animal fixing device 6 and the connecting port 5a of the atomizing chamber 3 .

The animal fixing device 6 has an atomizing chamber 3 connecting socket 5b; the animal fixing device 6 and the spring plug with holes 7 are detachably inserted and connected.

The device of the utility model is used for the positioning and atomization device required in the animal experiment process of the inhalation drug delivery system research. In the animal experimental research process of the inhalation drug delivery system, it can achieve the purpose of inhaling the mist droplets from the respiratory tract of rodents. Compared with the prior art, the utility model has the advantages, taking the hexagonal column as an example:

The atomization chamber 3 is a hexagonal prism, and an animal fixture 6 can be placed on each of the six sides. This design can ensure that six animals in a group can evenly inhale the same amount of liquid medicine, and ensure a uniform external environment and parallel operations. This device can achieve multi-layer through the lock device, that is, after the top cover is removed, fix the six sides of 2-3 atomization chambers with locks, and then install the top cover on the top to realize double-layer or multi-layer atomization. This device can realize simultaneous nebulization of 6n animals (n=1, 2, 3, . . . ). When there are many experimental animals in each group, this device can be used for atomization in the same way, and the volume of the atomization chamber increases in the same proportion. The animal fixation device can fix the animal in a closed space, only the respiratory tract is exposed to the atomization chamber, so that the animal can fully inhale the atomized liquid medicine, while other parts are free from contact with the liquid medicine, which is different from the fog made by many laboratories at present. Compared with the optimized device, the absorption of the liquid medicine in parts other than the respiratory tract (such as the skin) is reduced. Animal fixtures can also be customized in different sizes according to the size of experimental animals, and can be applied to different types of rodents such as rats, mice, and nude mice. At the same time, the baffle in front of the spring plug is made of silicone material, which is relatively soft, and can slowly push the animal into the holder, increasing the comfort of the experimental animal and preventing the animal from resisting. There is a small hole in the spring plug in the animal fixing device, so that the tail of the animal is exposed, which can be used for injection and drug administration, increasing the possibility of combined drug administration to experimental animals. All parts of the device can be disassembled to avoid cross-contamination when performing different experiments, and it is very convenient to clean. Different types of atomization devices can be connected to the inlet of atomized liquid medicine. Therefore, the device can also be used to evaluate the atomization efficiency of different types of atomizers on the market and their effects on different rodents. The animal fixing device 6 is a narrow space, which just caters to the living habits of rodents who like to drill holes. Experiments have proved that the animals are quieter and will not resist when atomized.

Description of drawings:

Figure 1 is a schematic diagram of the top cover; Figure 2 is a schematic diagram of an atomization chamber; Figure 3 is a schematic diagram of an animal immobilization device; Figure 4 is a schematic diagram of a single-layer device; where 1 is the inlet hole for the atomized liquid medicine; 2 is the air outlet hole; 3 is the mist 4 is the locking hole; 5 is the connecting port between the animal fixing device and the atomization chamber; 6 is the animal fixing device; 7 is a spring plug with holes.

Detailed ways

Embodiment: Carry out atomization inhalation experiment to 6 (or 12, 18, etc.) animals at the same time.

First, put 6 experimental animals into the animal fixing device 6 respectively, plug the spring plug 7 with holes to fix the animals, and connect the animal fixing device 6 with the atomization chamber lock 5 and the atomization chamber 3 through the animal fixing device (Can be sealed with parafilm if necessary). Then use an ultrasonic nebulizer or a compressed nebulizer to atomize a certain amount of medicinal liquid into mist droplets, and introduce it into the atomization chamber 3 through the catheter through the atomized medicinal liquid inlet 1. When the mist is filled with the mist chamber, the animal can inhale the mist. Chemical liquid. Finally, the inhalation time of the animals was controlled according to the experimental requirements. After completing the experiment, all parts can be disassembled for cleaning.

Claims (2)

1. a detachable rodent nebulization equipment, is characterized in that, it forms primarily of top cover (1), atomization chamber (3), animal fixing device (6) and spring plug with holes (7); Top cover (1) has atomization medicinal liquid entrance (1a), atomization medicinal liquid entrance (1a) is cylindrical projections; Top cover (1) there is 2-4 aperture (2) of giving vent to anger; Top cover (1) there is 2-10 for top cover (1) and the bonnet lock hole (4) of atomization chamber (3) integrated connection; Atomization chamber (3) there is 2-10 for top cover (1) and the bonnet lock hole (4) of atomization chamber (3) integrated connection; Atomization chamber (3) has 1-3 layer; Layer 2-3 atomization chamber is by bonnet lock hole (4) integrated connection; Atomization chamber (3) there is the seam (5a) of animal fixing device (6) and atomization chamber (3); Animal fixing device (6) there is the linking socket (5b) of atomization chamber (3); Animal fixing device (6) with spring plug (7) with holes for detachable insertion is connected.

2. detachable rodent nebulization equipment as claimed in claim 1, is characterized in that: atomization chamber (3) is six prisms.