CN1985878B - Medicine composition for treating peptic ulcer and its preparing method - Google Patents

Abstract

The invention provides a pharmaceutical composition for treating peptic ulcer and a preparation method thereof. The drug is made from total licorice flavonoids, sodium copper chlorophyllin, octopus, and propantheline bromide. The medicine of the present invention has anti-inflammatory effects on liver-qi invading the stomach (disharmony between the liver-stomach), damp-heat stagnation and steaming (damp-heat holding damp), spleen-stomach deficiency and coldness, stomach-yin deficiency (stomach-yin deficiency), liver depression and spleen deficiency (blood stasis obstructing collaterals) type peptic ulcer. Good therapeutic effect.

Description

A kind of pharmaceutical composition for treating peptic ulcer and preparation method thereof

technical field

The invention relates to the field of medicine, in particular to a pharmaceutical composition for treating peptic ulcer and a preparation method thereof.

Background technique

Peptic ulcer mainly refers to gastric ulcer and duodenal ulcer. There are two reasons for the development of peptic ulcer. On the one hand, it is due to the destruction of the self-protection ability of the gastric and duodenal mucosa. Such as frequent eating of rough and irritating food and taking aspirin, prednisone, alcohol, etc., as well as reflux of duodenal fluid, can damage the gastric mucosal barrier and reduce the self-protection ability of the stomach and duodenum . At this time, gastric acid and pepsin, which have the function of digesting protein, can easily penetrate the gastric mucosal barrier, digest and erode their own gastric or duodenal mucosa, and form ulcers. On the other hand, due to various reasons, the secretion of gastric acid and pepsin increases. In this case, even if the self-protection ability of the gastric and duodenal mucosa is normal, it cannot cope with the erosion of excessive gastric acid and pepsin, and ulcers are easy to form. . Such as genetic factors or gastrinoma, or excessive mental stress and bad emotions can directly cause vagus nerve excitement, increase gastric juice secretion, and increase gastric acid and pepsin secretion. Peptic ulcer generally has a long course of disease and is characterized by periodic attacks and rhythmic pain. It is prone to outbreaks in late autumn, winter, and when the weather and solar terms change. The main symptom is pain in the stomach (heart cavity, upper abdomen). Gastric ulcer pain is mostly on the left side, and duodenal ulcer pain is mostly on the right side. The pain rhythm of gastric ulcer is comfortable half to one hour after eating, then starts to hurt, and feels comfortable again after the stomach is completely emptied (about 4 hours after eating), that is, eating→comfort→pain→comfort. The pain rhythm of duodenal ulcer is no pain from 1.5 hours to 4 hours after eating, the pain starts when you are hungry (when the stomach is empty), and it will not be relieved until the next meal, that is, eating→comfort→pain, Call it "fasting pain." Other symptoms of ulcer disease are belching, acid reflux, salivation, nausea and vomiting.

Peptic ulcer belongs to the categories of "acid swallowing" and "epigastric pain" in traditional Chinese medicine. Traditional Chinese medicine believes that the etiology and pathogenesis of this disease are mainly due to emotional injury, diet fatigue and so on. Anxiety, anger, stimulation of the seven emotions, liver failure to disperse and vent, invading the stomach and internal organs; or stagnation of the spleen, abnormal transportation and transformation; improper diet or partial addiction, damage to the spleen and stomach; Ulcers occur. Excessive physical or mental work for a long time will damage the spleen and consume qi, stagnation of transportation and transformation, loss of qi and blood, and gastric membrane failure, which is prone to this disease. The location of the disease is in the stomach, which is most closely related to the liver and spleen. In terms of pathogenesis transformation, it has the characteristics of transformation from qi and blood, from excess to deficiency, transformation from cold to heat, or transformation from cold to yang and heat to yin. Clinical treatment mainly focuses on soothing the liver and harmonizing the stomach, warming the middle and invigorating the spleen, nourishing yin and benefiting the stomach, promoting blood circulation and removing blood stasis, and regulating cold and heat.

At present, the western medicines for treating peptic ulcer are mainly antacids, gastric acid secretion inhibitors and gastric mucosal protective agents. Antacids are mainly sodium bicarbonate, calcium carbonate, aluminum hydroxide, and bismuth subcarbonate. Commonly used compound preparations made of antacids include: Weishuping, aluminum-magnesium mixture, Weiyangning, Ledewei, compound calcium, bismuth, and magnesium, etc. . Gastric acid secretion inhibitors can reduce gastric juice secretion, relieve spasm and relieve pain, and promote ulcer healing. Commonly used compound or unilateral preparations are Dianru Tablets, Probensine, 654-2, Atropine, Anisodamine, Pipirazepine, and Mesocyanide Miguanidine, Famotidine, Omeprazole, Lansoprazole, Ranitidine, Losec. Commonly used gastric mucosal protective agents are Livzon Dele, Mazilin, Sucralfate and so on. Although these drugs have a quick onset of action, after taking the drug, the heart rate increases, palpitations, flushing, abdominal distension, dry mouth, nausea, diarrhea, abdominal pain, paresthesia, dizziness, headache, visual impairment, skin itching, urticaria, shortness of breath, shortness of breath Phenomena such as difficulty are also common side effects of these drugs. Traditional Chinese medicine treatment of peptic ulcer is often determined by dialectics and treatment, and different drug treatments are used according to different symptoms. For peptic ulcer of cold type, Huangqi Jianzhong Decoction and Heliangfu Pills are commonly used; for peptic ulcer of stomach yin deficiency type, Yiguan decoction is commonly used; for peptic ulcer of blood stasis type, Shixiao San and Danshen drink are commonly used; Lianpu Yin and Banxia Xiexin Decoction are often used for sexual ulcers; Huagan decoction is often used for peptic ulcers with stagnation of liver and stomach heat. Although this diagnosis and treatment can treat peptic ulcer well, its own characteristics determine that it cannot be suitable for industrialized production and application.

Contents of the invention

The object of the present invention is to provide a pharmaceutical composition for treating peptic ulcer.

Another object of the present invention is to provide a preparation method of the pharmaceutical composition for treating peptic ulcer.

The pharmaceutical composition of the invention is prepared from licorice total flavonoids, sodium copper chlorophyllin, cuttlefish and propantheline bromide.

The dosage and proportioning of each component of the medicine of the present invention are obtained through a large number of explorations and experiments by the inventor. The raw materials of each component have good curative effects in the following proportioning ranges by weight: 98.5 to 256 parts of total licorice flavonoids , sodium copper chlorophyllin 5.4-21.6 parts, sea octopus 64-155.4 parts, propantheline bromide 1.44-5.76 parts.

The raw materials of each component of the preferred pharmaceutical composition of the present invention have good curative effects in the following proportioning ranges by weight: 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22 to 3.78 parts of propantheline bromide.

The best raw materials of each component of the pharmaceutical composition of the present invention have good curative effects in the following proportioning ranges by weight: 128 parts of total flavonoids of licorice, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, 2.88 parts of propantheline bromide share.

In the key composition of the present invention, the total flavonoid content of the licorice is 35%-80% of the pharmaceutical composition.

The preparation and preparation of the active components of the composition of the present invention can adopt the following methods: extraction method, water extraction method, water extraction alcohol precipitation method, extraction method, dipping method, percolation method, reflux extraction method, continuous reflux extraction method, large It can be prepared by one or several combined application of porous resin adsorption method. For example, these raw materials can be ground into powder and mixed evenly to make powder for blunt administration; these drugs can also be decocted together, and then the decoction can be concentrated to make oral liquid; Effectiveness, the present invention best adopts the following process to extract the active components of the present invention for raw materials, but this cannot limit the protection scope of the present invention.

In the present invention, sodium copper chlorophyllin and propantheline bromide raw materials are commercially available.

In the medicine of the present invention, the total flavonoids of Radix Glycyrrhiza is obtained by the following method:

Take licorice, heat and extract 1 to 4 times, each time for 0.5 to 4 hours, combine the extracts, filter, add an appropriate amount of water to the filtrate, add calcium chloride solution, stir at 50 to 100°C for 5 to 60 minutes, let stand, and cool After the precipitation is complete, centrifuge, wash the precipitate with water, discard the washing liquid by centrifugation, and retain the precipitate; add 2 to 12 times the amount of 65 to 99% ethanol in the precipitate, adjust the pH to 1 to 5 with sulfuric acid, and let stand. Centrifuge to obtain the first centrifugate and precipitate, add 2 to 8 times the amount of 60-99% ethanol to the precipitate, adjust the pH to 1-5 with sulfuric acid, let stand, centrifuge to obtain the second centrifuge, combine 2 The centrifuged liquid is adjusted to pH 5-9 with 35-65% NaOH, the ethanol is recovered, concentrated and dried to obtain the total flavonoids of licorice.

In the preferred medicine of the present invention, the total flavonoids of Glycyrrhizae is obtained by the following method:

Take 50-200kg of licorice, heat and extract 2-3 times, 1-3 hours each time, combine the extracts, filter, add an appropriate amount of water to the filtrate, add calcium chloride solution, stir at 70-90°C for 20-40 minutes, let it stand Place and cool; after the precipitation is complete, centrifuge, wash the precipitate with water at 70-100°C, discard the washing liquid by centrifugation, and keep the precipitate; add 4-8 times the amount of 85-95% ethanol to the precipitate, and use sulfuric acid to adjust the pH to 2 to 4, stand still, and centrifuge to obtain the first centrifugate and precipitate; add 3 to 6 times the amount of 85 to 95% ethanol to the precipitate, adjust the pH to 2 to 4 with sulfuric acid, stand still, and centrifuge to obtain the second The second centrifugation solution is combined, the pH is adjusted to 6-8 with 45-55% NaOH, the ethanol is recovered, concentrated and dried to obtain the total flavonoids of licorice.

The medicine of the present invention can be made into any preparation in pharmacy; Granules, pills, powders, dripping pills; optimally made into oral liquids, tablets, capsules, granules, dripping pills, and soft capsules.

In the best medicine of the present invention, the total flavonoids of Glycyrrhizae is obtained by the following method:

Take 100 kg of licorice, extract it with boiling water for 3 times, the first time for 3 hours, the second and third times for one hour each, combine the extracts, filter, adjust its volume to 100 liters, add 16 kg of calcium chloride while it is hot Calcium chloride solution dissolved in 1 liter of water, stirred at 80°C for 30 minutes, allowed to stand, and cooled; after the precipitation was complete, centrifuged to separate, and washed with boiling water, the washing liquid was discarded by centrifugation, and the precipitate was retained; 6 times the amount of 93% ethanol in the precipitate, adjust the ph to 3 with sulfuric acid, let it stand still after fully stirring, and centrifuge to obtain the first centrifugal liquid, add 4 times the amount of 90% ethanol to the obtained precipitate, adjust the ph to 3 with sulfuric acid, and stir thoroughly Stand still, centrifuge to obtain the second centrifugate, combine the two centrifugates, use 50% NaOH to adjust the pH to 6-7, recover ethanol, concentrate, and dry to obtain the total flavonoids of licorice.

In the following drug preparation process, the proportioning of the bulk drug can be any proportioning, preferably the proportioning of the bulk drug is within the dosage range provided by the present invention.

The preparation method of the oral liquid of pharmaceutical composition of the present invention, comprises the steps:

a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use;

b. Sea slugs are extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add water, boil for 1 to 60 minutes, filter; potting, pressing the cap, and passing through Sterilize by steam at 90-150°C for 10-60 minutes to obtain the oral liquid.

The preparation method of preferred pharmaceutical composition oral liquid of the present invention, comprises the steps:

a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide;

b. Sea slugs are extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add water, boil for 5 to 40 minutes, filter; potting, capping, and then pass Sterilize by steam at 100-120°C for 20-40 minutes to obtain the oral liquid.

The preparation method of the best pharmaceutical composition oral liquid of the present invention comprises the steps:

a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide;

b. Extract the squid octopus with water or ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add water, stir and boil for 10-30 minutes to fully dissolve, and keep it hot Filter; press the cap, and then sterilize by steam at 105°C for 30 minutes to obtain the oral liquid. .

The preparation method of the capsule of pharmaceutical composition of the present invention, comprises the steps:

a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 60-200 mesh sieve; the total flavonoids of licorice and sea octopus are separately crushed into fine powder, passed through a 60-200 mesh sieve, and the four herbs are mixed evenly with appropriate amount of starch, and mixed with 5 ~35% starch slurry is used as a binder, made into granules, dried, granulated, and packed into capsules.

The preparation method of the capsule of preferred pharmaceutical composition of the present invention, comprises the steps:

a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through 80-120 mesh sieves; licorice total flavonoids and cuttlebone octopus are respectively crushed into fine powder, passed through 80-120 mesh sieves, and the four herbs are mixed evenly with appropriate amount of starch, and mixed with 8 ~25% starch slurry is used as a binder, made into granules, dried, granulated, and packed into capsules.

The preparation method of the capsule of best pharmaceutical composition of the present invention, comprises the steps:

a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 100-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately crushed into fine powder, passed through a 100-mesh sieve, the four herbs are mixed with appropriate amount of starch, and mixed with 15% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

The preparation method of the granule of pharmaceutical composition of the present invention, comprises the steps:

a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 60-200 mesh sieve; the total flavonoids of licorice and sea octopus are separately pulverized into fine powder, passed through a 60-200 mesh sieve, and the four herbs are mixed with commonly used auxiliary materials for granules to prepare into granules and dried to obtain granules.

The preparation method of the granule of preferred pharmaceutical composition of the present invention, comprises the steps:

a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 80-120 mesh sieve; the total flavonoids of licorice and sea octopus are separately crushed into fine powder, passed through a 80-120 mesh sieve, and the four herbs are mixed evenly with appropriate amount of powdered sugar to prepare into granules and dried to obtain granules.

The preparation method of the granule of the best pharmaceutical composition of the present invention, comprises the steps:

a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 100-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately crushed into fine powder, passed through a 100-mesh sieve, and the four herbs are mixed with an appropriate amount of sugar powder to make granules and dried , to obtain granules.

The preparation method of the dropping pill of pharmaceutical composition of the present invention, comprises the steps:

a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use;

b. Seaweed octopus is extracted with water or ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, add polyethylene glycol 6000, polyethylene glycol 4000, polyethylene glycol One or more combinations of 1500, heat to melt, drop into the condensed liquid, the dropping speed is 10-90 drops/min, and the dropping pills are obtained.

The preparation method of the drop pill of preferred pharmaceutical composition of the present invention, comprises the steps:

a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide;

b. Extract the squid octopus with water or ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, add polyethylene glycol 6000: polyethylene glycol 4000 = 1 ~ 5: The mixture of 1-5 is heated and melted, dripped into liquid paraffin, or methyl silicone oil, or the condensate of methyl silicone oil: liquid paraffin = 3:1, and the dropping speed is 20-80 drops/min, and the dropping pills are obtained.

The preparation method of the drop pill of best pharmaceutical composition of the present invention, comprises the steps:

a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide;

b. Extract the squid octopus with water or ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2, and heat Melt it and drop it into liquid paraffin at a rate of 25-75 drops/min to obtain a dropping pill.

The preparation method of the soft capsule of pharmaceutical composition of the present invention, comprises the steps:

a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use;

b. Sea octopus is extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, and a base, wherein the base is selected from vegetable oil, polyethylene glycol, or Tween One or any combination of 80; mix well, and homogenize with a homogenizer for 10-60 minutes to obtain the contents of the soft capsule; the proportion of each component of the capsule contents: pharmaceutical composition 2-40%, matrix 10-50 %, 0.5-2% glycerin, 1-15% water, and Tween as the balance; take the above-mentioned contents and press the soft capsule with a rotary capsule rolling machine.

The preparation method of the soft capsule of preferred pharmaceutical composition of the present invention, comprises the steps:

a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide;

b. Sea octopus is extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, and a base, wherein the base is selected from vegetable oil, polyethylene glycol, or Tween One or any combination of 80; mix well, and use a homogenizer to homogenize for 20-40 minutes to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 4-20% of the pharmaceutical composition, 20-30% of the matrix %, 1-1.5% glycerin, 4-8% water, and Tween as the balance; take the above-mentioned contents and press the soft capsule with a rotary capsule rolling machine.

The preparation method of the soft capsule of best pharmaceutical composition of the present invention, comprises the steps:

a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide;

b. Sea octopus is extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, and a base, wherein the base is selected from vegetable oil, polyethylene glycol, or Tween One or any combination of 80; mix well, and homogenize with a homogenizer for 30 minutes to obtain the contents of the soft capsule; the proportion of each component of the capsule contents: pharmaceutical composition 12.75%, matrix 25%, glycerin 1.25%, 5% water, 56% Tween; take the above content and compress the soft capsule with a rotary capsule rolling machine.

In the content of the soft capsule of the present invention, the vegetable oil in the base is one or any combination of rapeseed oil, soybean oil, peanut oil, sunflower oil, cottonseed oil, corn oil, sesame oil, olive oil, and safflower oil.

Preferably, in the content of the soft capsule of the present invention, the vegetable oil in the base is one or any combination of soybean oil, peanut oil, and olive oil.

In the present invention, the vegetable oil used may be refined vegetable oil, such as soybean oil is refined soybean oil.

In the preparation process of the above oral liquid, tablet, capsule, granule, dropping pill, and soft capsule, the selected total flavonoids of licorice, sodium copper chlorophyllin, octopus, and the dosage of propantheline bromide can be arbitrary, but preferably The raw material medicine provided by the present invention is provided by weight ratio. The above components can be increased or decreased according to the corresponding proportion during production. For example, the unit of kilogram or ton can be used for large-scale production, and the unit of gram can also be used for small-scale production, and the weight can be increased or decreased. The weight ratio of crude drug materials between them remains unchanged.

Detailed ways

In order to better understand the present invention, the beneficial effects of the present invention are illustrated below through clinical observation.

Clinical Observation on Treatment of Gastric Ulcer with Gankewei Tablets

According to the diagnosis of gastric ulcer and TCM classification, 247 patients were selected, including 186 males and 88 females, the youngest was 12 years old and the oldest was 77 years old, most of them were between 30 and 50 years old, and the disease course was as short as half a year , up to 21 years.

According to the location, nature, and time of the same position, combined with other concurrent diseases, syndrome differentiation and treatment are carried out. Common clinical conditions are divided into liver qi attacking the stomach (disharmony between the liver and the stomach), damp-heat stagnant steaming (damp-heat holding damp), spleen-stomach deficiency and cold, Insufficient stomach yin (stomach yin deficiency), liver depression and spleen deficiency (blood stasis blocking collaterals) and other types.

The relationship between TCM classification and curative effect:

Efficacy Judgment Criteria

1. Healing: consciously disappearing of upper abdominal pain, or only occasional discomfort, disappearing of tenderness, disappearance of ulcer from endoscopy or X-ray barium meal examination, irritation and tenderness disappearing.

2. Significantly effective: the perceived pain and tenderness are significantly relieved, the niche shadow in the X-ray barium meal examination is significantly reduced, the ulcer enters the healing period under the gastroscope, and the stimulation and tenderness are mild.

3. Effective: Pain and tenderness relieved or basically disappeared, X-ray barium meal examination niche shrinks, and stimulation tenderness improves.

4. Ineffective: no improvement in perceived pain, tenderness and X-ray examination.

Clinical Observation Results of 247 Cases

project get well Significantly effective efficient invalid

Number of cases 43 79 105 20

Through clinical observation, it is found that the total effective rate of glycopyrrolate tablets for peptic ulcer disease reaches 91.90%.

In the medicament of the present invention, the active ingredient of the licorice total flavonoids is obtained by the following method, but this cannot limit the present invention.

Preparation method one of licorice total flavonoids in the medicine of the present invention

Take licorice, heat and extract 4 times, each time for 4 hours, combine the extracts, filter, add an appropriate amount of water to the filtrate, add calcium chloride solution, stir at 100°C for 5 minutes, let stand, and cool; after the precipitation is complete, centrifuge Separation, washing the precipitate with water, centrifuging and discarding the washing liquid, and retaining the precipitate; adding 12 times the amount of 99% ethanol to the precipitate, adjusting the pH to 3-5 with sulfuric acid, standing still, and centrifuging to obtain the first centrifugal liquid and precipitate, Add 8 times the amount of 99% ethanol to the precipitate, adjust the pH to 3-5 with sulfuric acid, let it stand, and centrifuge to obtain the second centrifugal liquid, combine the two centrifugal liquids, adjust the pH to 7-9 with 65% NaOH, and recover ethanol , concentrated and dried to obtain the total flavonoids of licorice.

Preparation method two of licorice total flavonoids in the medicine of the present invention

Take licorice, heat and extract twice, each time for 2 hours, combine the extracts, filter, add an appropriate amount of water to the filtrate, add calcium chloride solution, stir at 50°C for 60 minutes, let stand, and cool; after the precipitation is complete, centrifuge Separation, washing the precipitate with water, centrifuging and discarding the washing liquid, and retaining the precipitate; adding 2 times the amount of 65% ethanol to the precipitate, adjusting the pH to 2-4 with sulfuric acid, standing still, and centrifuging to obtain the first centrifugal liquid and precipitate, Add 2 times the amount of 60% ethanol to the precipitate, adjust the pH to 2-4 with sulfuric acid, let it stand still, and centrifuge to obtain the second centrifugal liquid, combine the two centrifugal liquids, adjust the pH to 5-7 with 35% NaOH, and recover ethanol , concentrated and dried to obtain the total flavonoids of licorice.

Preparation method three of licorice total flavonoids in the medicine of the present invention

Take 200kg of licorice, heat and extract 3 times, each time for 3 hours, combine the extracts, filter, add an appropriate amount of water to the filtrate, add calcium chloride solution, stir at 90°C for 40 minutes, let stand, and cool; after the precipitation is complete, Centrifuge, wash the precipitate with water at 100°C, discard the washing liquid by centrifugation, and retain the precipitate; add 8 times the amount of 95% ethanol to the precipitate, adjust the pH to 2-4 with sulfuric acid, let stand, and centrifuge to obtain the first centrifugal liquid and precipitation; add 6 times the amount of 95% ethanol to the precipitation, adjust the pH to 2-4 with sulfuric acid, let it stand, and centrifuge to obtain the second centrifugal liquid, combine the two centrifugal liquids, and adjust the pH to 6-8 with 55% NaOH , recovering ethanol, concentrating, and drying to obtain total flavonoids of licorice.

Preparation method four of licorice total flavonoids in the medicine of the present invention

Take 50kg of licorice, heat and extract twice, 1 hour each time, combine the extracts, filter, add an appropriate amount of water to the filtrate, add calcium chloride solution, stir at 70°C for 20 minutes, let stand, and cool; after the precipitation is complete, Centrifuge, wash the precipitate with water at 70°C, discard the washing liquid by centrifugation, and retain the precipitate; add 4 times the amount of 85% ethanol to the precipitate, adjust the pH to 2-4 with sulfuric acid, let stand, and centrifuge to obtain the first centrifugal liquid and precipitation; add 3 times the amount of 85% ethanol to the precipitation, adjust the pH to 2 to 4 with sulfuric acid, let it stand, and centrifuge to obtain the second centrifugal liquid, combine the two centrifugal liquids, and adjust the pH to 6 to 8 with 45% NaOH , recovering ethanol, concentrating, and drying to obtain total flavonoids of licorice.

Preparation method five of licorice total flavonoids in the medicine of the present invention

Take 80 kg of licorice, heat and extract 3 times, the first time is 3 hours, the second time is 2 hours, the third time is 1 hour, the extracts are combined, filtered, the filtrate is added with an appropriate amount of water, calcium chloride solution is added, and stirred at 85 ° C for 35 Minutes, stand still, cool; after the precipitation is complete, centrifuge, wash the precipitate with water at 90°C, centrifuge and discard the washing solution, and keep the precipitate; add 5 times the amount of 91% ethanol to the precipitate, and adjust the pH to 2-4 with sulfuric acid , stand still, centrifuge to obtain the first centrifugate and precipitate; add 3 to 6 times the amount of 93% ethanol to the precipitate, adjust the pH to 2 to 4 with sulfuric acid, stand still, and centrifuge to obtain the second centrifuge, Combine the two centrifuges, adjust the pH to 6-8 with 48% NaOH, recover ethanol, concentrate, and dry to obtain the total flavonoids of licorice.

Preparation method six of licorice total flavonoids in the medicine of the present invention

Take 100 kg of licorice, extract 3 times with boiling water, 3 hours for the first time, 1 hour for the second and third times, combine the extracts, filter, adjust the volume to 100 liters, and add 16 kg of calcium chloride while it is hot. Calcium chloride solution dissolved in 1 liter of water, stirred at 80°C for 30 minutes, allowed to stand, and cooled; after the precipitation was complete, centrifuged to separate, and washed with boiling water, the washing liquid was discarded by centrifugation, and the precipitate was retained; 6 times the amount of 93% ethanol in the precipitate, adjust the ph to 3 with sulfuric acid, let it stand still after being fully stirred, and centrifuge to obtain the first centrifugal liquid, add 4 times the amount of 90% ethanol to the obtained precipitate, adjust the ph to 3 with sulfuric acid, and stir thoroughly Stand still, centrifuge to obtain the second centrifugate, combine the two centrifugates, adjust pH 6 to 7 with 50% NaOH, recover ethanol, concentrate, and dry to obtain total flavonoids of licorice.

The preparation method of the medicament of the present invention is further illustrated by the following examples. The total flavonoids of licorice used in the following examples were prepared according to the sixth preparation method of total flavonoids of licorice.

Example 1

a. Take prescription 1: licorice total flavonoids 98.5g, sodium copper chlorophyllin 5.4g, cuttlefish octopus 64g, propantheline bromide 1.44g for later use;

b. Sea octopus is extracted with water, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add water, boil for 60 minutes, filter; potting, capping, and steaming at 150°C to extinguish Bacteria for 10 minutes to obtain oral liquid.

Example 2

a. Take prescription 2: 256g total flavonoids of licorice, 21.6g sodium copper chlorophyllin, 155.4g sea octopus, 5.76g propantheline bromide for standby;

b. Ethanol extract, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add water, boil for 1 minute, filter; potting, capping, and steaming at 90°C Sterilize for 60 minutes to obtain the oral liquid.

Example 3

a. Take prescription three: licorice total flavonoids 130g, sodium copper chlorophyllin 16g, sea octopus 80g, propantheline bromide 3.76g.

b. The squid octopus is extracted with 99% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add water, boil for 5 minutes, filter; potting, pressing, and then Sterilize by steaming at 90°C for 15 minutes to obtain the oral liquid.

Example 4

a. Take prescription 4: licorice total flavonoids 110g, sodium copper chlorophyllin 8.5g, sea octopus 90g, propantheline bromide 2.22g for later use;

b. The squid octopus is extracted with 75% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add water, boil for 20 minutes, filter; potting, capping, Then pass steam to sterilize at 100° C. for 30 minutes to obtain the oral liquid.

Example 5

a. Take prescription five: licorice total flavonoids 180g, sodium copper chlorophyllin 15.4g, cuttlefish octopus 140g, propantheline bromide 3.78g for later use;

b. Sea octopus is extracted with water, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add water, boil for 5 minutes, filter; potting, capping, and steaming at 120°C Bacteria for 40 minutes to obtain oral liquid.

Example 6

a. Take prescription six: licorice total flavonoids 120g, sodium copper chlorophyllin 20g, sea octopus 100g, propantheline bromide 2.5g for later use;

b. Extract with ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add water, boil for 40 minutes, filter; potting, capping, and steaming at 100°C Sterilize for 20 minutes to obtain the oral liquid.

Example 7

a. Take prescription 7: 150g of total licorice flavonoids, 10g of sodium copper chlorophyllin, 70g of octopus, 2.7g of propantheline bromide;

b. Extract the octopus with 10% ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add water, boil for 10 minutes, filter; potting, capping, and steaming Sterilize at 105°C for 25 minutes to obtain the oral liquid.

Example 8

a. Take prescription eight: licorice total flavonoids 128g, sodium copper chlorophyllin 10.8g, sea octopus 128g, propantheline bromide 2.88g for later use;

b. Extract the squid octopus with 60% ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add water, stir and boil for 30 minutes to fully dissolve, and filter while hot press the cap, and then sterilize by steam at 105°C for 30 minutes to obtain the oral liquid.

Example 9

a. Take prescription eight: licorice total flavonoids 128g, sodium copper chlorophyllin 10.8g, sea octopus 128g, propantheline bromide 2.88g for later use;

b. Extract the squid octopus with water, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add water, stir and boil for 20 minutes to fully dissolve, and filter while hot; , and then sterilized by steam at 105°C for 30 minutes to obtain the oral liquid.

Example 10

A. get prescription, and prescription is standby with embodiment 1;

b. Sodium copper chlorophyllin and propantheline bromide are passed through a 200-mesh sieve respectively; the total flavonoids of licorice and octopus are separately crushed into fine powder, passed through a 200-mesh sieve, the four herbs are mixed evenly with appropriate amount of starch, and mixed with 35% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 11

A. get prescription, and prescription is standby with embodiment 2;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 60-mesh sieve; the total flavonoids of licorice and octopus are separately crushed into fine powder, passed through a 60-mesh sieve, and the four herbs are mixed evenly with appropriate amount of starch, and mixed with 5% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 12

A. get prescription, and prescription is standby with embodiment 3;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 120-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately crushed into fine powder, passed through a 120-mesh sieve, and the four herbs are mixed evenly with an appropriate amount of starch, and mixed with 15% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 13

A. get prescription, and prescription is standby with embodiment 4;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 100-mesh sieve; the total flavonoids of licorice and octopus are separately crushed into fine powder, passed through a 100-mesh sieve, and the four herbs are mixed evenly with appropriate amount of starch, and mixed with 10% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 14

A. get prescription, and prescription is standby with embodiment 5;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 120 mesh sieve; the total flavonoids of licorice and octopus are separately crushed into fine powder, passed through a 120 mesh sieve, the four herbs are mixed evenly with appropriate amount of starch, and mixed with 25% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 15

A. get prescription, and prescription is standby with embodiment 5;

b. Sodium copper chlorophyllin and propantheline bromide are passed through 80-mesh sieve respectively; licorice total flavonoids and sea crocodile octopus are separately ground into fine powder, passed through 80-mesh sieve, and the four herbs are mixed evenly with appropriate amount of starch, and mixed with 8% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 16

A. get prescription, and prescription is standby with embodiment 6;

b. Sodium copper chlorophyllin and propantheline bromide are passed through 80-mesh sieve respectively; total flavonoids of licorice and octopus are separately ground into fine powder, passed through a 120-mesh sieve, and the four herbs are mixed evenly with appropriate amount of starch, and mixed with 12% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 17

A. get prescription, and prescription is standby with embodiment 7;

b. Sodium copper chlorophyllin and propantheline bromide are passed through 80-mesh sieve respectively; total flavonoids of licorice and octopus are separately crushed into fine powder, passed through a 100-mesh sieve, the four herbs are mixed evenly with appropriate amount of starch, and mixed with 14% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 18

A. get prescription, and prescription is standby with embodiment 8;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 100-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately crushed into fine powder, passed through a 100-mesh sieve, the four herbs are mixed with appropriate amount of starch, and mixed with 15% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules.

Example 19

A. get prescription, and prescription is standby with embodiment 1;

b. Sodium copper chlorophyllin and propantheline bromide are passed through a 200-mesh sieve respectively; the total flavonoids of licorice and sea octopus are separately pulverized into fine powder, passed through a 200-mesh sieve, mixed with four herbs and cyclodextrin, made into granules, dried, That is, granules.

Example 20

A. get prescription, and prescription is standby with embodiment 2;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 60-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately ground into fine powder, passed through a 60-mesh sieve, mixed with the four herbs and starch, made into granules, dried, and obtained Granules.

Example 21

A. get prescription, and prescription is standby with embodiment 3;

b. Sodium copper chlorophyllin and propantheline bromide are passed through a 120-mesh sieve respectively; the total flavonoids of licorice and sea crocodile octopus are separately pulverized into fine powder, passed through a 60-mesh sieve, mixed with the four herbs and dextrin, made into granules, and dried, namely Get granules.

Example 22

A. get prescription, and prescription is standby with embodiment 4;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 100-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately pulverized into fine powder, passed through a 120-mesh sieve, mixed with the four herbs and lactose, made into granules, dried, and obtained Granules.

Example 23

A. get prescription, and prescription is standby with embodiment 5;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 120-mesh sieve; the total flavonoids of licorice and octopus are separately crushed into fine powder, passed through a 120-mesh sieve, and the four herbs are mixed evenly with an appropriate amount of powdered sugar to make granules and dried , to obtain granules.

Example 24

A. get prescription, and prescription is standby with embodiment 6;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 80-mesh sieve; the total flavonoids of licorice and octopus are separately crushed into fine powder, passed through a 80-mesh sieve, the four herbs are mixed evenly with appropriate amount of sugar powder, made into granules, and dried , to obtain granules.

Example 25

A. get prescription, and prescription is standby with embodiment 7;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 120-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately crushed into fine powder, passed through a 80-mesh sieve, the four herbs are mixed evenly with appropriate amount of dextrin, made into granules, and dried , to obtain granules.

Example 26

A. get prescription, and prescription is standby with embodiment 8;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 80-mesh sieve; the total flavonoids of licorice and octopus are separately crushed into fine powder, passed through a 120-mesh sieve, and the four herbs are mixed evenly with an appropriate amount of stevioside to make granules and dried , to obtain granules.

Example 27

A. get prescription, and prescription is standby with embodiment 8;

b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 100-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately crushed into fine powder, passed through a 100-mesh sieve, and the four herbs are mixed with an appropriate amount of sugar powder to make granules and dried , to obtain granules.

Example 28

A. get prescription, and prescription is standby with embodiment 1;

b. Seaweed octopus is extracted with water, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide fraction, and total flavonoids of licorice, add 5.5 times the amount of polyethylene glycol 6000, heat to melt, and drop into the condensate , the dropping speed is 50-70 drops/min, and the dropping pills are obtained.

Example 29

A. get prescription, and prescription is standby with embodiment 2;

b. Seaweed octopus is extracted with ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, and total flavonoids of licorice, add 2 times the amount of polyethylene glycol 4000, heat to melt, and drop into the condensate In the process, the dropping speed is 80-90 drops/min, and the dropping pills are obtained.

Example 30

A. get prescription, and prescription is standby with embodiment 3;

b. Seaweed octopus is extracted with 75% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheine bromide, and total flavonoids of licorice, add 4 times the amount of polyethylene glycol 1500, heat to melt, drop into In the condensate, the dropping speed is 40-50 drops/min, and the dropping pills are obtained.

Example 31

A. get prescription, and prescription is standby with embodiment 4;

b. Seaweed octopus is extracted with 35% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, and total flavonoids of licorice, and add 3 times the amount of polyethylene glycol 6000 and polyethylene glycol A mixture of 4000 alcohols with a weight of 1:1 is heated and melted, and dropped into the condensate at a rate of 60-70 drops/min to obtain drop pills.

Example 32

A. get prescription, and prescription is standby with embodiment 5;

b. Seaweed octopus is extracted with water, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, add 4 times the amount of polyethylene glycol 6000 and polyethylene glycol 4000, and the weight is 2 The mixture of ratio 1 is heated and melted, and dropped into the condensate at a rate of 40-50 drops/min to obtain the dropping pill.

Example 33

A. get prescription, and prescription is standby with embodiment 6;

b. Seaweed octopus is extracted with 5% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, and add 7 times the amount of polyethylene glycol 6000 and polyethylene glycol 1500 The mixture with a weight ratio of 5 to 1 is heated and melted, and dropped into the condensate at a dropping speed of 20-30 drops/min to obtain a dropping pill.

Example 34

A. get prescription, and prescription is standby with embodiment 7;

b. Seaweed octopus is extracted with water, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, add 12 times the amount of polyethylene glycol 6000, polyethylene glycol 4000 and polyethylene glycol The mixture of diol 1500 with a weight ratio of 3 to 2 to 1 is heated and melted, and dropped into the condensate at a rate of 45-55 drops/min to obtain a drop pill.

Example 35

A. get prescription, and prescription is standby with embodiment 1;

b. Seaweed octopus is extracted with 70% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, add polyethylene glycol 6000: polyethylene glycol 4000 = 5: 1, heated and melted, and dropped into liquid paraffin at a rate of 70-80 drops/min to obtain dropping pills.

Example 36

A. get prescription, and prescription is standby with embodiment 2;

b. Seaweed octopus was extracted with 65% ethanol, concentrated, and dried to obtain the extract, then took sodium copper chlorophyllin, propanthene bromide, and total flavonoids of licorice, and added 10 times the amount of polyethylene glycol 6000: polyethylene glycol Alcohol 4000 = 1:5 mixture, heat to melt, drop into methyl silicone oil, drop rate is 20-50 drops/min, and drop pills are obtained.

Example 37

A. get prescription, and prescription is standby with embodiment 3;

b. The squid octopus is extracted with water, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propanthene bromide, and total flavonoids of licorice, and add 2 times the amount of polyethylene glycol 6000: polyethylene glycol 4000 = 4: 1, heated and melted, dripped into the condensate of methyl silicone oil: liquid paraffin = 3:1, and the dropping speed was 40-50 drops/min, and the dropping pills were obtained.

Example 38

A. get prescription, and prescription is standby with embodiment 4;

b. Seaweed octopus is extracted with 85% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, add polyethylene glycol 6000: polyethylene glycol 4000 = 2 : 1 mixture, heat to melt, drop into liquid paraffin at -10 to 10°C, and the dropping speed is 45-60 drops/min, to obtain dropping pills.

Example 39

A. get prescription, and prescription is standby with embodiment 5;

b. The squid octopus is extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propanthene bromide, and total licorice flavonoids, and add 20 times the amount of polyethylene glycol 6000: polyethylene glycol 4000= The mixture of 2:3 is heated to melt, and dropped into 8°C methyl silicone oil at a rate of 55-65 drops/min to obtain drop pills.

Example 40

A. get prescription, and prescription is standby with embodiment 6;

b. Seaweed octopus is extracted with 45% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, and total flavonoids of licorice, and add 8 times the amount of polyethylene glycol 6000: polyethylene glycol Alcohol 4000 = 4:3 mixture, heat to melt, drop into 0 ° C methyl silicone oil: liquid paraffin = 3:1 condensate, the dropping speed is 65-70 drops/min, and drop pills are obtained.

Example 41

A. get prescription, and prescription is standby with embodiment 8;

b. The squid octopus is extracted with water, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, and add 6 times the amount of polyethylene glycol 6000: polyethylene glycol 4000 = 3:2 The mixture is heated and melted, and dropped into liquid paraffin at a rate of 65-75 drops/min to obtain dropping pills.

Example 42

A. get prescription, and prescription is standby with embodiment 8;

b. The squid octopus is extracted with ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, and add 5 times the amount of polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2, heat to melt, drop into liquid paraffin at a rate of 25-30 drops/min, to obtain dropping pills.

Example 43

A. get prescription, and prescription is standby with embodiment 1;

b. The squid octopus is extracted with water, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, and a matrix, wherein the matrix is selected from a combination of vegetable oil and Tween 80; mix well, Homogenize with a homogenizer for 60 minutes to obtain the contents of the soft capsule; the proportion of the components of the capsule contents: 40% of the pharmaceutical composition, 50% of refined soybean oil, 2% of glycerin, 1% of water, and 7% of Tween; The above-mentioned contents are compressed into soft capsules with a rotary capsule rolling machine.

Example 44

A. get prescription, and prescription is standby with embodiment 2;

b. Ethanol extraction of squid octopus, concentration, and drying to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, and substrate, wherein the substrate is vegetable oil; mix well, and homogenize for 40 minutes with a homogenizer , to obtain the content of the soft capsule; the proportioning of each component of the capsule content: 35% of the pharmaceutical composition, 50% of vegetable oil, 1% of glycerin, and 14% of water; the above-mentioned content is pressed into a soft capsule with a rotary capsule rolling machine.

Example 45

A. get prescription, and prescription is standby with embodiment 3;

b. The squid octopus is extracted with 75% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, and a substrate, wherein the substrate is peanut oil and Tween 80; mix well, Homogenize with a homogenizer for 60 minutes to obtain the contents of the soft capsule; the proportioning of each component of the capsule contents: 30% of the pharmaceutical composition, 20% of peanut oil, 0.5% of glycerin, 15% of water, and 38.5% of Tween; The contents are compressed into soft capsules with a rotary capsule rolling machine.

Example 46

A. get prescription, and prescription is standby with embodiment 4;

b. Seaweed octopus is extracted with 99% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, polyethylene glycol, and Tween 80; mix well and use well Homogenize with a chemical machine for 10 minutes to obtain the content of the soft capsule; the proportioning ratio of the components of the capsule content: 20% of the pharmaceutical composition, 20% of polyethylene glycol, 2% of glycerin, 15% of water, and 43% of Tween; The above-mentioned contents are compressed into soft capsules with a rotary capsule rolling machine.

Example 47

A. get prescription, and prescription is standby with embodiment 5;

b. The squid octopus is extracted with ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, vegetable oil, and Tween 80; mix well, and use a homogenizer to homogenize After 40 min, the contents of the soft capsule are obtained; the proportioning of each component of the capsule contents: 10% of the pharmaceutical composition, 50% of vegetable oil, 1% of glycerin, 10% of water, and 29% of Tween; Capsule machine compresses soft capsules.

Example 48

A. get prescription, and prescription is standby with embodiment 6;

b. The squid octopus is extracted with 75% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, polyethylene glycol, and Tween 80; mix well, Homogenize with a homogenizer for 50 minutes to obtain the contents of the soft capsule; the proportion of the components of the capsule contents: 8% of the pharmaceutical composition, 45% of polyethylene glycol, 1.5% of glycerin, 8% of water, and 37.5% of Tween ; Take the above-mentioned content and press the soft capsule with a rotary capsule rolling machine.

Example 49

A. get prescription, and prescription is standby with embodiment 4;

b. The squid octopus is extracted with ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, and a substrate, wherein the substrate is selected from vegetable oil, polyethylene glycol or Tween 80 The combination; mix, and homogenize with a homogenizer for 40min to obtain the contents of the soft capsule; the ratio of each component of the capsule contents: 20% of the pharmaceutical composition, 20% of vegetable oil, 10% of polyethylene glycol, 10% of glycerin %, water 4%, Tween 45%; get the above-mentioned content and compress the soft capsule with a rotary capsule rolling machine.

Example 50

A. get prescription, and prescription is standby with embodiment 5;

b. The squid octopus is extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, and a base, wherein the base is selected from vegetable oil, polyethylene glycol, and Tween 80 combination; mix well, and homogenize for 20 minutes with a homogenizer to obtain the contents of the soft capsule; the proportioning ratio of each component of the capsule contents: 15% of the pharmaceutical composition, 30% of vegetable oil, 20% of polyethylene glycol, glycerin 1.5%, water 8%, Tween 25.5%; take the above content and press the soft capsule with a rotary capsule rolling machine.

Example 51

A. get prescription, and prescription is standby with embodiment 6;

b. Sea octopus is extracted with 35% ethanol, concentrated, and dried to obtain extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, and a substrate, wherein the substrate is selected from vegetable oil and Tween 80. Combination; mixing, and homogenizing with a homogenizer for 30 minutes to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 10% of the pharmaceutical composition, 20% of vegetable oil, 2% of glycerin, 5% of water, Tween 63%; Get above-mentioned content and compress soft capsule with rotary capsule rolling machine.

Example 52

A. get prescription, and prescription is standby with embodiment 8;

b. Sea slugs are extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, water, vegetable oil, and Tween 80; mix well, and use a homogenizer Homogenize for 30 minutes to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 12.75% of the pharmaceutical composition, 25% of vegetable oil, 1.25% of glycerin, 5% of water, and 56% of Tween; Capsule rolling machine compresses soft capsules.

Example 53

A. get prescription, and prescription is standby with embodiment 1;

b. The squid octopus is extracted with water, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, water, olive oil, and Tween 80; mix well, and use a homogenizer Homogenize by machine for 55 minutes to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 33% of the pharmaceutical composition, 30% of olive oil, 1% of glycerin, 1% of water, and 35% of Tween; take the above contents Compress the soft capsules with a rotary capsulator.

Example 54

A. get prescription, and prescription is standby with embodiment 2;

b. Ethanol extraction of squid octopus, concentration, and drying to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, water, peanut oil; mix well, and homogenize for 20 minutes with a homogenizer, to obtain Contents of the soft capsule; the ratio of each component of the capsule content: 8% of the pharmaceutical composition, 40% of peanut oil, 1% of glycerin, 11% of water, and 40% of Tween; the above-mentioned contents are pressed into a soft capsule with a rotary capsule rolling machine .

Example 55

A. get prescription, and prescription is standby with embodiment 3;

b. Seaweed octopus is extracted with 75% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, water, vegetable oil, and Tween 80; mix well, and use a homogenizer Homogenize by machine for 15 minutes to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 30% of the pharmaceutical composition, 20% of soybean oil, 0.5% of glycerin, 15% of water, and 38.5% of Tween; Soft capsules are compressed by a rotary capsule rolling machine.

Example 56

A. get prescription, and prescription is standby with embodiment 4;

b. Extract the squid octopus with 65% ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, polyethylene glycol, water, refined soybean oil, peanut oil, olive oil , Tween 80; mix well, and homogenize with a homogenizer for 25 minutes to obtain the contents of the soft capsule; the proportioning ratio of each component of the capsule contents: 10% of the pharmaceutical composition, 20% of polyethylene glycol, and 10% of refined soybean oil , peanut oil 1%, olive oil 1%, glycerin 0.5%, water 10.5%, Tween 47%: get the above-mentioned contents and compress soft capsules with a rotary capsule rolling machine.

Example 57

A. get prescription, and prescription is standby with embodiment 5;

b. The squid octopus is extracted with 5% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, rapeseed oil, water, and Tween 80; mix well , and homogenize with a homogenizer for 30 minutes to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 13.2% of the pharmaceutical composition, 57% of rapeseed oil, 0.8% of glycerin, 15% of water, and 14% of Tween ; Take the above-mentioned content and press the soft capsule with a rotary capsule rolling machine.

Example 58

A. get prescription, and prescription is standby with embodiment 6;

b. Extract the octopus with 45% ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, water, sunflower oil, and Tween 80; mix well , homogenize with a homogenizer for 45min to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 18% of the pharmaceutical composition, 25% of sunflower oil, 0.5% of glycerin, 10% of water, and 46.5% of Tween ; Take the above-mentioned content and press the soft capsule with a rotary capsule rolling machine.

Example 59

A. get prescription, and prescription is standby with embodiment 4;

b. The squid octopus is extracted with ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, vegetable oil, polyethylene glycol, water, and Tween 80; mix Homogenize for 40 minutes with a homogenizer to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 20% of the pharmaceutical composition, 20% of vegetable oil, 10% of polyethylene glycol, 1% of glycerin, and 4% of water %, Tween 45%; get the above-mentioned content and compress the soft capsule with a rotary capsule rolling machine.

Example 60

A. get prescription, and prescription is standby with embodiment 5;

b. Extract the octopus with water or ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, water, cottonseed oil, polyethylene glycol, and Tween 80. Mix well, and homogenize for 20 minutes with a homogenizer to obtain the content of the soft capsule; the proportion of the components of the capsule content: 20% of the pharmaceutical composition, 40% of cottonseed oil, 10% of polyethylene glycol, and 1.5% of glycerin , water 5%, Tween 23.5%; take the above content and press the soft capsule with a rotary capsule rolling machine.

Example 61

A. get prescription, and prescription is standby with embodiment 6;

b. The squid octopus is extracted with 75% ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, total licorice flavonoids, add glycerin, self-corn oil, water, and Tween 80; Mix well, and homogenize for 30 minutes with a homogenizer to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 10% of the pharmaceutical composition, 20% of corn oil, 2% of glycerin, 5% of water, and Tween 63 %; Take the above-mentioned content and compress the soft capsule with a rotary capsule rolling machine.

Example 62

A. get prescription, and prescription is standby with embodiment 7;

b. Extract the squid octopus with water or ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, water, and sesame oil; mix well, and use a homogenizer to homogenize for 30 minutes. The content of the soft capsule is obtained; the proportion of the components of the capsule content is: 45% of the pharmaceutical composition, 45% of sesame oil, 1% of glycerin, and 9% of water; the above-mentioned content is pressed into a soft capsule with a rotary capsule rolling machine.

Claims (25)

1. A pharmaceutical composition for treating peptic ulcer, characterized in that it is made of the following crude drugs in proportions by weight: 98.5 to 256 parts of total flavonoids of licorice, 5.4 to 21.6 parts of sodium copper chlorophyll, 64 parts of seaweed and octopus ～155.4 parts, 1.44～5.76 parts of propantheline bromide. 2. The pharmaceutical composition for treating peptic ulcer as claimed in claim 1, characterized in that it is made of the following raw materials in proportions by weight: 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin , octopus 90-140 parts, propantheline bromide 2.22-3.78 parts. 3. The pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 2, characterized in that it is made from the raw materials in the following proportions by weight: 128 parts of total flavonoids of licorice, 10.8 parts of sodium copper chlorophyll, octopus 128 parts, 2.88 parts of propantheline bromide. 4. The pharmaceutical composition for treating peptic ulcer according to claim 1, characterized in that the total flavonoids of licorice are prepared by the following method: take licorice, heat and extract 1 to 4 times, each time for 0.5 to 4 hours, and combine the extracts , filter, add an appropriate amount of water to the filtrate, add calcium chloride solution, stir at 50-100°C for 5-60 minutes, let stand, and cool; Reserve; add 2-12 times the amount of 65-99% ethanol to the precipitate, adjust the pH to 1-5 with sulfuric acid, let it stand, and centrifuge to obtain the first centrifugal liquid and precipitate, add 2-8 times the amount to the precipitate 60-99% ethanol, adjust the pH to 1-5 with sulfuric acid, let it stand, and centrifuge to obtain the second centrifugal liquid, combine the two centrifugal liquids, adjust the pH to 5-9 with 35-65% NaOH, recover the ethanol, concentrate, Dried to obtain the total flavonoids of licorice. 5. The pharmaceutical composition for treating peptic ulcer as claimed in claim 4, characterized in that the total flavonoids of licorice are prepared by the following method: take 50-200 kg of licorice, heat and extract 2-3 times, each time for 1-3 hours, Combine the extracts, filter, add an appropriate amount of water to the filtrate, add calcium chloride solution, stir at 70-90°C for 20-40 minutes, let stand, and cool; after the precipitation is complete, centrifuge, wash the precipitate with water at 70-100°C, The washing liquid was centrifuged and discarded, and the precipitate was retained; adding 4-8 times the amount of 85-95% ethanol to the precipitate, adjusting the pH to 2-4 with sulfuric acid, standing still, and centrifuging to obtain the first centrifugal liquid and precipitate; Add 3 to 6 times the amount of 85 to 95% ethanol, adjust the pH to 2 to 4 with sulfuric acid, let it stand, and centrifuge to obtain the second centrifugal liquid, combine the two centrifugal liquids, and adjust the pH to 6 to 6 with 45 to 55% NaOH 8. Recover ethanol, concentrate and dry to obtain total flavonoids of licorice. 6. The pharmaceutical composition for treating peptic ulcer as claimed in claim 5, wherein the total flavonoids of licorice is prepared by the following method: get 100 kilograms of licorice, extract 3 times with boiling water, the first time for 3 hours, the second, Three times for one hour each, combine the extracts, filter, adjust its volume to 100 liters, add a calcium chloride solution dissolved in 4 kg of calcium chloride and 16 liters of water while it is hot, stir at 80°C for 30 minutes, and let it stand , cooled; after the precipitation is complete, centrifuge, and wash the precipitate with boiling water, discard the washing liquid by centrifugation, and keep the precipitate; add 6 times the amount of 93% ethanol to the precipitate, adjust the pH to 3 with sulfuric acid, and let it stand after fully stirring. Centrifuge to obtain the first centrifugate, add 4 times the amount of 90% ethanol to the resulting precipitate, adjust the pH to 3 with sulfuric acid, let it stand after fully stirring, centrifuge to obtain the second centrifugate, combine the two centrifuges, and use 50 Adjust the pH to 6-7 with % NaOH, recover the ethanol, concentrate and dry to obtain the total flavonoids of licorice. 7. The pharmaceutical composition for treating peptic ulcer as claimed in claim 1, 2 or 3, characterized in that the pharmaceutical composition is made into oral liquid, tablet, capsule, granule, dripping pill. 8. The pharmaceutical composition for treating peptic ulcer as claimed in claim 1, 2 or 3, characterized in that the pharmaceutical composition is made into a soft capsule. 9. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 1, is characterized in that the preparation method of oral liquid comprises the steps: a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use; b. Sea slugs are extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add water, boil for 1 to 60 minutes, filter; potting, pressing the cap, and passing through Sterilize by steam at 90-150°C for 10-60 minutes to obtain the oral liquid. 10. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 2, is characterized in that the preparation method of oral liquid comprises the steps: a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide; b. Sea slugs are extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add water, boil for 5 to 40 minutes, filter; potting, capping, and then pass Sterilize by steam at 100-120°C for 20-40 minutes to obtain the oral liquid. 11. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 3 is characterized in that the preparation method of oral liquid comprises the steps: a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide; b. Extract the squid octopus with water or ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add water, stir and boil for 10-30 minutes to fully dissolve, and keep it hot Filter; press the cap, and then sterilize by steam at 105°C for 30 minutes to obtain the oral liquid. 12. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 1, is characterized in that the preparation method of capsule comprises the steps: a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use; b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 60-200 mesh sieve; the total flavonoids of licorice and sea octopus are separately crushed into fine powder, passed through a 60-200 mesh sieve, and the four herbs are mixed evenly with appropriate amount of starch, and mixed with 5 ~35% starch slurry is used as a binder, made into granules, dried, granulated, and packed into capsules. 13. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 2, it is characterized in that the preparation method of capsule comprises the steps: a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide; b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through 80-120 mesh sieves; licorice total flavonoids and cuttlebone octopus are respectively crushed into fine powder, passed through 80-120 mesh sieves, and the four herbs are mixed evenly with appropriate amount of starch, and mixed with 8 ~25% starch slurry is used as a binder, made into granules, dried, granulated, and packed into capsules. 14. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 3 is characterized in that the preparation method of capsule comprises the steps: a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide; b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 100-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately crushed into fine powder, passed through a 100-mesh sieve, the four herbs are mixed with appropriate amount of starch, and mixed with 15% starch slurry Used as a binder, made into granules, dried, granulated, and packed into capsules. 15. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 1, it is characterized in that the preparation method of granule comprises the steps: a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use; b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 60-200 mesh sieve; the total flavonoids of licorice and sea octopus are separately pulverized into fine powder, passed through a 60-200 mesh sieve, and the four herbs are mixed with commonly used auxiliary materials for granules to prepare into granules and dried to obtain granules. 16. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 2, it is characterized in that the preparation method of granule comprises the steps: a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide; b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 80-120 mesh sieve; the total flavonoids of licorice and sea octopus are separately crushed into fine powder, passed through a 80-120 mesh sieve, and the four herbs are mixed evenly with appropriate amount of powdered sugar to prepare into granules and dried to obtain granules. 17. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 3, it is characterized in that the preparation method of granule comprises the steps: a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide; b. Sodium copper chlorophyllin and propantheline bromide are respectively passed through a 100-mesh sieve; the total flavonoids of licorice and sea crocodile octopus are separately crushed into fine powder, passed through a 100-mesh sieve, and the four herbs are mixed with an appropriate amount of sugar powder to make granules and dried , to obtain granules. 18. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 1, is characterized in that the preparation method of dropping pill comprises the steps: a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use; b. Seaweed octopus is extracted with water or ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, add polyethylene glycol 6000, polyethylene glycol 4000, polyethylene glycol One or more combination of 1500, heated and melted, dripped into the condensed liquid, the dropping speed is 10-90 drops/min, and the dripping pills are obtained. 19. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 2, it is characterized in that the preparation method of dropping pill comprises the steps: a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide; b. Extract the squid octopus with water or ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propanthene bromide, total licorice flavonoids, add polyethylene glycol 6000: polyethylene glycol 4000 = 1 ~ 5: The mixture of mixtures of 1 to 5 is heated and melted, and dropped into liquid paraffin, or methyl silicone oil, or methyl silicone oil: liquid paraffin = 3:1 condensate, and the dropping speed is 20-80 drops/min. pill. 20. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 3 is characterized in that the preparation method of dropping pill comprises the steps: a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide; b. Extract the squid octopus with water or ethanol, concentrate, and dry to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total flavonoids of licorice, add polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2, and heat Melt it and drop it into liquid paraffin at a rate of 25-75 drops/min to obtain a dropping pill. 21. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 1, is characterized in that the preparation method of soft capsule comprises the steps: a. Take 98.5-256 parts of total licorice flavonoids, 5.4-21.6 parts of sodium copper chlorophyllin, 64-155.4 parts of sea octopus, and 1.44-5.76 parts of propantheline bromide for later use; b. Sea octopus is extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, and a base, wherein the base is selected from vegetable oil, polyethylene glycol, or Tween One or any combination of 80; mix well, and homogenize with a homogenizer for 10-60 minutes to obtain the contents of the soft capsule; the proportion of each component of the capsule contents: pharmaceutical composition 2-40%, matrix 10-50 %, 0.5-2% glycerin, 1-15% water, and Tween as the balance; take the above-mentioned contents and press the soft capsule with a rotary capsule rolling machine. 22. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 2, it is characterized in that the preparation method of soft capsule comprises the steps: a. 110-180 parts of total licorice flavonoids, 8.5-15.4 parts of sodium copper chlorophyllin, 90-140 parts of sea octopus, 2.22-3.78 parts of propantheline bromide; b. Sea octopus is extracted with water or ethanol, concentrated, and dried to obtain an extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, and a base, wherein the base is selected from vegetable oil, polyethylene glycol, or Tween One or any combination of 80; mix well, and use a homogenizer to homogenize for 20-40 minutes to obtain the contents of the soft capsule; the ratio of the components of the capsule contents: 4-20% of the pharmaceutical composition, 20-30% of the matrix %, 1-1.5% glycerin, 4-8% water, and Tween as the balance; take the above-mentioned contents and press the soft capsule with a rotary capsule rolling machine. 23. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 3, it is characterized in that the preparation method of soft capsule comprises the steps: a. Get 128 parts of total licorice flavonoids, 10.8 parts of sodium copper chlorophyllin, 128 parts of sea octopus, and 2.88 parts of propantheline bromide; b. The squid octopus is extracted with water or ethanol, concentrated, and dried to obtain the extract, then take sodium copper chlorophyllin, propantheline bromide, and total licorice flavonoids, add glycerin, and a base, wherein the base is selected from vegetable oil, polyethylene glycol, or Tween One or any combination of 80; mix well, and homogenize with a homogenizer for 30 minutes to obtain the contents of the soft capsule; the proportion of each component of the capsule contents: pharmaceutical composition 12.75%, matrix 25%, glycerin 1.25%, 5% water, 56% Tween; take the above content and compress the soft capsule with a rotary capsule rolling machine. 24. the preparation method of the pharmaceutical composition for the treatment of peptic ulcer as claimed in claim 23 is characterized in that the vegetable oil in the matrix is rapeseed oil, soybean oil, peanut oil, sunflower oil, cottonseed oil, corn oil, sesame oil, olive oil, safflower oil, or any combination. 25. The preparation method of the pharmaceutical composition for treating peptic ulcer as claimed in claim 24, characterized in that the vegetable oil in the matrix is one or any combination of soybean oil, peanut oil, olive oil.