CN1706419A - Chronic gastrosis treating effective component composition and its prepn and use - Google Patents
Chronic gastrosis treating effective component composition and its prepn and use Download PDFInfo
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Abstract
The present invention features that effective components are extracted from Chinese medicinal materials corydalis tuber, licorice and Dangshen, combined in certain proportion and added with medicinal excipient to prepare proper preparation form. Prepared with corydalis tuber for promoting blood circulation to disperse blood clots, invigorating vital energy and relieving pain, licorice for benefiting vital energy and invigorating spleen and stomach and relieving pain, and Dangshen for invigorating spleen and stomach, benefiting vital energy and promoting the secretion one saliva, the present invention has the functions of relieving pain, inhibiting the secretion of gastric acid, protecting stomach mucous membrane, etc. and may be used in treating chronic gastritis and digestive tract ulcer mainly.
Description
Technical field:
The invention belongs to Chinese medicine development field, relate to a kind of active component composition and preparation and purposes that cures mainly chronic gastropathy, be specifically related to a kind of active component composition that from Chinese crude drug Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis, extracts and suitable dosage form and the medical usage aspect the treatment of chronic gastropathies such as chronic gastritis, digestive tract ulcer thereof.
Background technology:
Chronic gastritis is a kind of gastric mucosa inflammatory lesion that causes owing to the sexual stimulus that comes to harm for a long time, repeated friction damage, irregular eating, reason such as unhappy, is commonly called as stomachache.Digestive tract ulcer claims stomach, duodenal ulcer again, it is the general name of gastric ulcer and duodenal ulcer, the two can be fallen ill simultaneously and also can fall ill separately, occur in the gastric ulcer that cries of stomach, occur in the bulboduodenal duodenal bulbar ulcer that just cries, because it is comparatively similar with Therapeutic Method that the pathogenesis of the two, symptom show, so medically usually be collectively referred to as digestive tract ulcer.These two kinds of diseases that disease all is a multi-pathogenesis may be relevant with long-term Bad Eating Habit, some food (as cigarette, wine, strong tea, coffee etc.) long-time stimulus, immune dysfunction, infection, heredity, Nervous and Mental Factors etc.On Chinese medicine, chronic gastritis, digestive tract ulcer general designation gastric abscess claims stomachache again, is that to cause depression and stagnation of QI, stomach to be become homeless by diseases caused by exogenous pathogenic factor pathogen, internal injury diet feelings will, visceral dysfunction etc. foster, based on the disease of upper abdomen gastral cavilty portion nearly divergent bone place pain.This disease is a primary symptom with gastral cavilty portion pain, but has loss of appetite simultaneously concurrently, epigastric discomfort or dull pain, belch, return acid, feel sick, vomiting etc.The treatment of gastric abscess, at present Chinese medicine or western modern medicine have all been obtained notable therapeutic effect, no matter merely use Chinese medicine or western modern medicine can improve the symptom of stomachache effectively, reach the purpose of treatment.The medicine of western medicine gastropathy is a lot, but long-term prescription may produce drug resistance, and can toxic side effect.Compare with Western medicine, Chinese medicine has characteristics such as toxic and side effects is little, curative effect is lasting, and this just provides vast market for the Chinese medicine of treatment disease of stomach.
Lot of domestic and international medicine research staff is doing one's utmost to research and develop the medicine that can be good at treating chronic gastropathy such as illness such as chronic gastritis, digestive tract ulcer.In the past few years, we have also carried out the research of this respect with great concentration, have collected a large amount of documents and materials and information, attempt to break through existing technology, provide a kind of scientific and technological content higher stomach medicine of new generation.We are from the theory of curing the disease of the traditional Chinese medical science, and in conjunction with the result of study of modern pharmacology, three medicines are share give full play to the treatment that its effect is used for chronic gastropathy.Through the inquiry of relevant information, we search some about the patent of this three flavors Chinese medicine in treatment gastropathy direction.For example the patent No. is 93102359.9 " a kind of Chinese medicine preparation and method for making thereof for the treatment of gastric disease ", the patent No. is 98122151.3 " a kind of Chinese patent medicine for the treatment of gastropathy ", the patent No. is 00117361.8 " a kind of Chinese patent medicine for the treatment of peptic ulcer ", application number is 92111786.8 " ulcer curing tablet and manufacture method thereof are good for the stomach ", application number is to have used a kind of in above-mentioned three herbal medicines or two kinds in 98114182.x's a plurality of patents such as " Traditional Chinese medicine for treating gastropathy ", even three kinds.Find that these patents mostly are big compound recipe but carefully study carefully, mostly wherein used medicinal part is thick extraction, extractum of crude drug powder, medical material etc., the extraction process of medicinal ingredient is simple, its active constituent content is low, difficult quality control, be unfavorable for that Chinese medicine meets the internationalization requirement, explores world market.We do not find to form effective part group by pharmaceutical manufacturer or medical research organisations with regard to effective site Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and the Radix Codonopsis polysaccharide of Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis both at home and abroad in relevant inquiry, become the treatment that the appropriate drug preparation is used for chronic gastropathy with the production and processing of being used as medicine of this effective part group.
Summary of the invention:
The present invention is directed to the deficiencies in the prior art, a kind of effective site Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide that extracts from Chinese crude drug Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis is provided, it is formed effective part group, so that make three kinds of effective ingredient in the medicine bring into play the synergism of more powerful antiulcer, treatment chronic gastritis.
Another object of the present invention provides the preparation method of above-mentioned composition.
Further purpose of the present invention is to provide kind of the effective part group production and processing with above-mentioned three herbal medicines, with it as analgesia, antiulcer, the medicine that cures mainly chronic gastropathy and preparation thereof.
The active component that cures mainly the medicine of chronic gastropathy provided by the invention is effective site Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and the Radix Codonopsis polysaccharide (being effective part group) of Chinese crude drug that derives from Rhizoma Corydalis, Radix Glycyrrhizae and the Radix Codonopsis of certain proportion (this ratio see hereinafter describe).These three kinds of chemical compounds no matter be plant extract or derive from chemosynthesis, may be used among the active component of the present composition, and wherein the actual content of effective part group is not less than 70% of total extract.
The medicine that cures mainly chronic gastropathy of the present invention is promptly gone up the suitable pharmaceutical excipient of acceptable by above-mentioned effective part group and physiology and is formed.Dosage form of the present invention mainly is an oral formulations, comprises tablet such as ordinary tablet, slow releasing tablet, controlled release tablet, dispersible tablet, oral cavity disintegration tablet etc. and hard capsule, soft capsule, pill, granule, oral liquid etc.
Following detailed will help further to understand the present invention.
Unless otherwise indicated, the part term of this description is defined as follows:
Rhizoma Corydalis: or its crude drug, be meant the tuber of Papaveraceae Herba corydalis edulis plant Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) or the tcm and herbal slice that is made into.Rhizoma Corydalis is recorded in Tang the earliest. and CHEN Zang-Qi supplement to the Herbal and Lee give in to " Haiyao Bencao, Oversea Materia Medica ", another name " Rhizoma Corydalis ".Lei Gong's Treatise on Preparation and Broiling of Materia Medica is referred to as " Rhizoma Corydalis ".Its property hardship, suffering, warm in nature, be widely used in stagnation of QI and blood, trusted subordinate and limbs pain have the merit of blood-activating and qi-promoting, and that uses can make QI and blood unobstructed.With Rhizoma Corydalis section or coarse powder, be used for the extraction of effective site among the present invention.
Radix Glycyrrhizae: or its crude drug, be meant the root of pulse family Radix Glycyrrhizae plant platymiscium Radix Glycyrrhizae (Glycyrrhiza uralensis Fisch) and the tcm and herbal slice of root stock or making, its sweet in the mouth, property is flat, the merit that has QI invigorating invigorating middle warmer, relieving spasm to stop pain, lets out fire detoxifcation, coordinating the actions of various ingredients in a prescription.Among the present invention the Radix Glycyrrhizae coarse powder is used for the extraction of effective site.
Radix Codonopsis: or its crude drug, be meant the root of campanulaceae plant Radix Codonopsis (Codonopsis pilosula[Franch]) or the tcm and herbal slice that is made into, its sweet in the mouth is flat, effect with strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid, cure mainly weakness of the spleen and stomach, anorexia and loose stool, diseases such as deficiency of both QI and blood.The extraction of effective site will be used among the present invention behind the Radix Codonopsis undercut sheet.
Rhizoma Corydalis total alkaloids: be meant the total alkaloids of forming by the contained multiple alkaloid of traditional Chinese medicine corydalis tuber that from the Rhizoma Corydalis crude drug, extracts, and wherein the summation of multiple alkaloid is not less than 50% (w/w) of total extracted amount.Known Rhizoma Corydalis total alkaloids contains tetrahydropalmatine etc.
Radix Glycyrrhizae total flavones: be meant the Flavonoid substances that from the Radix Glycyrrhizae crude drug, extracts, and wherein general flavone content is not less than 80% (w/w) of total extracted amount.
Radix Codonopsis polysaccharide: be meant the polysaccharose substance that from the Radix Codonopsis crude drug, extracts, and wherein Radix Codonopsis polysaccharide content is not less than 80% (w/w) of total extract.
Effective part group: the compositions that is meant the Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and the Radix Codonopsis polysaccharide that from Chinese crude drug Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis, extract in the present invention; The compositions that combines that also refers to effective ingredient tetrahydropalmatine, effective site Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide, wherein the actual content of effective site be not less than total extract 70%, three the flavor crude drug ratio within certain limit described in the invention.
The present composition comprises that above-mentioned effective part group and physiology go up the acceptable pharmaceutical excipient.The effective part group that the effective site of the Rhizoma Corydalis in origin comes from specific " proportion ", Radix Glycyrrhizae and Radix Codonopsis three flavor crude drugs is formed, the proportion (w/w/w) of three flavor crude drugs is between 30: 10: 1 to 1: 1: 1, preferred proportion is between 20: 8: 1 to 4: 2: 1, and best proportion is 6: 3: 1.The preparation method of this effective part group is to extract Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide from Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis, separation, purification obtain active constituent content higher effective position, then they proportionally are combined into the main medicinal ingredient of effective part group as medicine.This effective part group is path preparation thus also: extract effective site Radix Glycyrrhizae total flavones, Radix Codonopsis polysaccharide from Radix Glycyrrhizae and Radix Codonopsis, add tetrahydropalmatine again and be combined into effective part group.The usage ratio (w/w) of crude drug that wherein is used to extract the Radix Glycyrrhizae of effective site and Radix Codonopsis is between 10: 1 to 1: 1, wherein the ratio (w/w) of tetrahydropalmatine of Jia Ruing and extract total amount is between 1: 10 to 1: 100, the consumption preferred proportion (w/w) of crude drug that is used to extract the Radix Glycyrrhizae of effective site and Radix Codonopsis is between 8: 1 to 2: 1, the tetrahydropalmatine that adds and the preferred proportion of extract total amount are between 1: 12 to 1: 30, the best proportion (w/w) of consumption that is used to extract the crude drug of the Radix Glycyrrhizae of effective site and Radix Codonopsis is 3: 1, and the tetrahydropalmatine that adds and the best proportion (w/w) of extract total amount are 1: 25.The solvent that is used to extract or extract usefulness in the preparation technology of effective part group can be water, ethanol, ethyl acetate, also can be other organic solvent.Above-mentioned effective part group both can be to derive from plant (Chinese crude drug) to extract, and also can derive from chemosynthesis or semi-synthetic.
The present invention also proposes to go up the Pharmaceutical composition that the acceptable pharmaceutical excipient is formed by above-mentioned " effective part group " and physiology.The dosage form of these Pharmaceutical compositions mainly is an oral formulations, comprises tablet such as ordinary tablet, slow releasing tablet, controlled release tablet, dispersible tablet, oral cavity disintegration tablet etc. and hard capsule, soft capsule, pill, granule, oral liquid etc.
Compare with prior art, the present invention has following novelty and advance on the whole: at first, from the compatibility of drugs aspect, this product is under the guidance of theory of Chinese medical science, to hundreds of medicine screen, optimum organization, final definite by carrying out compatibility approximately in three flavors, select Rhizoma Corydalis promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain for use in the side; The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, relieving spasm to stop pain; The Radix Codonopsis spleen reinforcing is good for the stomach, supplementing QI for promoting the production of body fluid.Used medicine had both met the treatment theory of Chinese medicine to chronic gastropathy, had also avoided big compound recipe to go into the various weak point of flavour of a drug number, had demonstrated fully scientific and reasonable compatibility and the complementary characteristics of effect of modern Chinese medicine; Secondly, the present invention is from the modern pharmacology result of study, and the extraction process of employing modern Chinese medicine is extracted Chinese crude drug in three flavors respectively refining, and the feasible abundant enrichment of effective ingredient wherein reaches content higher effective position, and optimum organization becomes effective part group again.In this compositions, each single effective site: Rhizoma Corydalis total alkaloids content 〉=50%; Radix Glycyrrhizae total flavones content 〉=80%; Radix Codonopsis polysaccharide content 〉=80%.Effective site content sum 〉=70% in the effective part group, effective part group after each effective site and the combination can adopt modern analysis such as high-efficient liquid phase analysis method, thin layer chromatography, uv analysis method to carry out reliable qualitative and quantitative analysis and detect, quality to medicine is controlled reliably, it is lower to have remedied present compound Chinese medicinal preparation scientific and technological content, active constituent content is low or indeterminate, deficiencies such as difficult quality control; Once more, from the curative effect aspect, this product is that three effective sites of distinguishing the flavor of medical materials are combined into effective part group according to suitable ratio proportioning, with the main component of this effective part group as medicine, the full side of three herbal medicines cooperates, and makes that the medicine complementation is short mutually, Synergistic, drug effect significantly increases, avoid the single deficiency of the about thing curative effect of single, also kept the effect of the tonification conditioning that three flavor Chinese medicines self are had simultaneously, reached the purpose for the treatment of both the principal and secondary aspects of a disease.
This product not only has good analgesic activity, can also secrete by gastric acid inhibitory, and the protection gastric mucosa improves gastric motility, regulates body's immunity etc., is the natural drug of new generation that cures mainly chronic gastritis, digestive tract ulcer disease.And this product learns the frontier of research in having opened up approximately, and Chinese medicine has been brought up to the height of effective site to the research of gastrotherapy, demonstrated fully modern medicine to the modern new demand of Study of Medicinal Herbs.
Description of drawings:
Fig. 1 is the process chart of embodiment 1;
Fig. 2 is the process chart of embodiment 2;
Fig. 3 is the The pharmacological results to the influence of rat swollen feet due to the Ovum Gallus domesticus album;
Fig. 4 is the The pharmacological results to the analgesic activity of mice;
Fig. 5 is the The pharmacological results of the effect (pylorus ligature law) of the experimental gastric ulcer of Chinese People's Anti-Japanese Military and Political College Mus;
Fig. 6 is the The pharmacological results of the effect (method of acetic acid) of the experimental gastric ulcer of Chinese People's Anti-Japanese Military and Political College Mus;
Fig. 7 is the The pharmacological results 7 to the influence of rat experiment gastritis gastric secretion.
The invention will be further described by the following examples, but be not limited in this.
Specific embodiment:
Embodiment 1
Get the effective part group of a certain proportion of Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide combination, drying, pulverizing, mistake 80 mesh sieves are crossed 80 mesh sieve mix homogeneously with microcrystalline Cellulose, ethanol system granule with 95%, forced air drying is with 20 mesh sieve granulate, the fill capsule, the polishing packing gets final product.
Prescription is formed: (1000) Rhizoma Corydalis total alkaloids 30g
Radix Glycyrrhizae total flavones 40g
Radix Codonopsis polysaccharide 30g
Microcrystalline Cellulose 75g
Accompanying drawing 1 is seen in its technological process.
Get the effective part group of certain proportion tetrahydropalmatine, Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide combination, drying, pulverizing, mistake 80 mesh sieves are crossed 80 mesh sieve mix homogeneously with microcrystalline Cellulose, carboxymethyl starch sodium, with 5%PVC system granule, forced air drying is with 20 mesh sieve granulate, add magnesium stearate, tabletting.
Prescription is formed: (1000) tetrahydropalmatine 25g
Radix Glycyrrhizae total flavones 50g
Radix Codonopsis polysaccharide 25g
Carboxymethyl starch sodium 5g
Microcrystalline Cellulose 68g
Magnesium stearate 2g
Accompanying drawing 2 is seen in its technological process.
Illustrate its drug action with The pharmacological results below:
One, to the influence of rat swollen feet due to the Ovum Gallus domesticus album:
Experimental technique:
Get 130-150g Wistar rat, the male and female dual-purpose is divided into 4 groups (normal saline group, guarantor's stomach I group, guarantor's stomach II group, sodium salicylate groups) at random, and every Mus makes a clear horizontal line in upper end, left back claw front with ball pen, and is long-pending with drainage survey Mus corpus unguis.Administration group gastric infusion is after 1 hour, and it is subcutaneous with the 0.25ml syringe 10% Ovum Gallus domesticus album to be injected the left back foot sole of the foot of rat, and it is long-pending once respectively to survey the Mus corpus unguis respectively at 0.5,1,2,4,6 hour, calculates Mus pawl swelling rate.
Experimental result:
This product significantly suppresses the effect of the rat paw edema due to the Ovum Gallus domesticus album, and antiinflammatory action is preferably arranged.Experimental result sees accompanying drawing 3 for details.
Two, to the analgesic activity (hot plate method) of mice:
Experimental technique:
Get the qualified female mice of screening and be divided into 4 groups (normal saline group, guarantor's stomach I group, guarantor's stomach II group, ibuprofen groups) at random, survey its pain threshold, every mice is surveyed to average for twice and is pain threshold before the medicine, administration group gastric infusion, survey pain threshold behind 30min, 60min, the 90min respectively, observe analgesic effect.The result represents with x ± sd.
Experimental result:
This product can the significant prolongation hot plate method causes the pain threshold of pain model mice, and analgesic effect is remarkable.Annotate: with comparison before the administration
*P＜0.05,
*P＜0.01,
* *P＜0.001.Experimental result sees accompanying drawing 4 for details.
Three, the effect of the experimental gastric ulcer of Chinese People's Anti-Japanese Military and Political College Mus (pylorus ligature law):
Experimental technique:
Get body weight the 150-180g rat, be divided into 4 groups (normal saline group, guarantor's stomach I group, guarantor's stomach II group, famotidine groups) at random, every group of equal successive administration is after 3 days, and fasting is after 48 hours, the capable pylorus ligation operation of etherization, stop to supply water, put to death rat after 18 hours, get stomach and cut off coat of the stomach along greater gastric curvature for food, clean content, coat of the stomach is launched to fix, observe the gastric mucosa face, write down ulcerogenic Mus number, ulcer number, ulcer level, ulcer index and pathological changes situation.The result represents with x ± sd.
Experimental result:
The incidence rate that this product can significantly suppress popular method ligation mouse gastric ulcer alleviates ulcer level, reduces ulcer index.Annotate: compare with normal saline
*P＜0.05,
*P＜0.01, experimental result are seen accompanying drawing 5 for details.
Four, to the effect (method of acetic acid) of rat experiment gastric ulcer:
Experimental technique:
Get the 150-180g rat, the male and female dual-purpose, be divided into 4 groups (normal saline group, guarantor's stomach I group, guarantor's stomach II group, famotidine groups) at random, etherization, hara kiri, gently be pulled to glandular stomach portion outside the abdomen, at the stomach facies ventralis, body of stomach and pyloric antrum intersection thrust 0.4-0.5mm under the serous coat so that microsyringe is flat, inject 10% acetic acid 0.05ml, form pimple.Stomach is sent back to gently, sew up stomach wall and skin, iodine disinfection.Operation rises next day, and administration group successive administration 7 days once a day, was put to death animal on the 8th day, gets stomach and immerses in 10% formalin fixedly 10min, cuts off along greater gastric curvature, and stomach is turned up, and washes out food debris, observes the ulcer situation, calculates ulcer index.The result represents with x ± sd.
Experimental result:
This product can suppress rat gastric ulcer due to the method for acetic acid generation, promote the healing of gastric ulcer.Annotate: compare with normal saline
*P＜0.01, experimental result are seen accompanying drawing 6 for details.
Five, to the influence of rat experiment gastritis gastric secretion:
Experimental technique:
Get body weight 180-200g SD rat, male and female half and half, sub-cage rearing, five in every cage, be divided into 5 groups (normal saline group, model group, guarantor's stomach I group, guarantor's stomach II group, famotidine groups) at random, every group of rat first month every 5 days, gavaged 60% alcoholic solution once every 7 days in the second month, each every 2ml, arbitrarily drink with the deoxycholic acid sodium solution replacement water of pH7.0-7.8,20mmol/L therebetween,, once arbitrarily drank by turns every 3 days then respectively with the deoxycholic acid sodium solution of 30% alcoholic solution and 20mmol/L in three month.Model group finished experiment in 90 days, then successive administration is once a day for the administration group, negative control group is given normal saline, each animal fasting be can't help water after 16 hours after 7 days, and the animal sacrificed by decapitation is got blood, cut open the belly immediately, ligation pylorus and cardia, extract full stomach, collect gastric juice and analyze, blood is through 3500rpm centrifuging and taking serum gastrin to be checked.And the gastric tissue bar of getting same area is liquid-solid fixed with 10% neutral formalin, and HE dyeing is observed pathological tissue and changed.The result represents with x ± sd.
Experimental result:
Long term administration, this product can significantly reduce the free acidity in the chronic gastritis rat model gastric juice, suppresses pepsic activity, plays the effect of protection gastric mucosa, and can stimulate the secretion of serum gastrin.Annotate: compare with normal saline
#P＜0.05,
##P＜0.01; Compare with model group
*P＜0.05,
*P＜0.01, experimental result are seen accompanying drawing 7 for details.
Claims (14)
1. active component composition that cures mainly chronic gastropathy, it is characterized in that comprising " effective part group " that cure mainly chronic gastritis, digestive tract ulcer that from Chinese crude drug Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis, extract, and the last acceptable pharmaceutical excipient of physiology, wherein " effective part group " is:
(1) extracts compound again compositions behind Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and the Radix Codonopsis polysaccharide respectively from a certain proportion of above-mentioned three flavor crude drugs;
(2) compositions of forming according to a certain percentage by tetrahydropalmatine, Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide.
2. compositions according to claim 1 is characterized in that the actual content of each effective site is not less than 70% of extract in the effective part group.
3. according to the compositions of claim 1, effective site wherein is the compositions of the Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and the Radix Codonopsis polysaccharide that extract from Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis three flavor crude drugs.
4. according to the compositions of claim 3, the usage ratio (w/w/w) of Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis three flavor crude drugs that wherein is used to extract effective part group is between 30: 10: 1 to 1: 1: 1.
5. according to the compositions of claim 4, the usage ratio (w/w/w) of Rhizoma Corydalis, Radix Glycyrrhizae and Radix Codonopsis three flavor crude drugs that wherein is used to extract effective part group is between 20: 8: 1 to 4: 2: 1.
6. according to the compositions of claim 5, the usage ratio (w/w/w) that wherein is used to extract Rhizoma Corydalis, Radix Glycyrrhizae and the Radix Codonopsis three flavor crude drugs of effective part group is 6: 3: 1.
7. according to the compositions of claim 1, the compositions that effective part group wherein is made of according to a certain percentage tetrahydropalmatine, Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide.
8. according to the compositions of claim 7, the crude drug ratio (w/w) that wherein is used to extract effective site Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide is between 10: 1 to 1: 1, and the ratio (w/w) of tetrahydropalmatine that adds and extract total amount is between 1: 10 to 1: 100.
9. compositions according to Claim 8, the crude drug ratio (w/w) that wherein is used to extract effective site Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide is between 8: 1 to 2: 1, and the ratio (w/w) of tetrahydropalmatine that adds and extract total amount is between 1: 12 to 1: 30.
10. according to the described compositions of claim 9, the crude drug ratio (w/w) that wherein is used to extract effective site Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide is 3: 1, and the tetrahydropalmatine that adds and the ratio (w/w) of extract total amount are 1: 25.
11. according to the compositions of claim 1, it is characterized by, improve gastric motility, regulate the application in the medicine of immunologic function at analgesia, antiulcer.
12. according to the compositions of claim 1, it is characterized in that in effective part group Rhizoma Corydalis total alkaloids, Radix Glycyrrhizae total flavones and Radix Codonopsis polysaccharide, adding suitable pharmaceutical excipient, be prepared into suitable dosage form.
13., it is characterized in that being also included within this effective part group fabrication and processing such as other effective ingredient, effective site and the synthetic that add similar medicinal direction or semi-synthetic and become suitable dosage form according to the compositions of claim 12.
14. dosage form according to the compositions of claim 12, it is characterized in that said dosage form is mainly is oral formulations, comprises tablet such as ordinary tablet, slow releasing tablet, controlled release tablet, dispersible tablet, oral cavity disintegration tablet etc. and capsule, soft capsule, granule, pill, oral liquid etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410041247 CN1706419A (en) | 2004-06-11 | 2004-06-11 | Chronic gastrosis treating effective component composition and its prepn and use |
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| CN 200410041247 CN1706419A (en) | 2004-06-11 | 2004-06-11 | Chronic gastrosis treating effective component composition and its prepn and use |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985878B (en) * | 2005-12-20 | 2011-06-22 | 广州王老吉药业股份有限公司 | Medicine composition for treating peptic ulcer and its preparing method |
| CN103190507A (en) * | 2013-04-25 | 2013-07-10 | 北京绿源求证科技发展有限责任公司 | Food health tea electuary capable of protecting gastric mucosa |
-
2004
- 2004-06-11 CN CN 200410041247 patent/CN1706419A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985878B (en) * | 2005-12-20 | 2011-06-22 | 广州王老吉药业股份有限公司 | Medicine composition for treating peptic ulcer and its preparing method |
| CN103190507A (en) * | 2013-04-25 | 2013-07-10 | 北京绿源求证科技发展有限责任公司 | Food health tea electuary capable of protecting gastric mucosa |
| CN103190507B (en) * | 2013-04-25 | 2014-01-15 | 北京绿源求证科技发展有限责任公司 | A food health tea granule for protecting gastric mucosa |
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