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CN1969641B - Children's sugar-free soy milk - Google Patents

Children's sugar-free soy milk Download PDF

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CN1969641B
CN1969641B CN2006101574066A CN200610157406A CN1969641B CN 1969641 B CN1969641 B CN 1969641B CN 2006101574066 A CN2006101574066 A CN 2006101574066A CN 200610157406 A CN200610157406 A CN 200610157406A CN 1969641 B CN1969641 B CN 1969641B
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soybean
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CN1969641A (en
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廖建湘
李成荣
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Shenzhen Childrens Hospital
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Abstract

本发明公开了一种小儿无糖豆奶,要解决的技术问题是配合小儿生酮饮食治疗癫痫,补充蛋白质和部分优质脂肪类营养素。本发明采用以下技术方案:一种小儿无糖豆奶,该豆奶由以下重量比组组成:水87-88%、大豆蛋白4-5%、红花油2-3%、椰子油2-3%、大豆油2-3%、磷酸钙、枸掾酸钾和氯化钾三者重量的和小于1%。本发明与现有技术相比,豆奶完全无糖,配合生酮饮食治疗癫痫时,提供优质蛋白质和部分优质脂肪类营养素,使用和计算方便,还可同时配合其他营养素治疗癫痫患儿,疗效肯定,特别是对部分现有药物无法控制发作的癫痫病人有效,未产生不能接受的副作用。The invention discloses a sugar-free soybean milk for children, and the technical problem to be solved is to treat epilepsy with a ketogenic diet for children, and supplement protein and some high-quality fat nutrients. The present invention adopts the following technical solutions: a sugar-free soybean milk for children, the soybean milk is composed of the following weight ratio: water 87-88%, soybean protein 4-5%, safflower oil 2-3%, coconut oil 2-3% , soybean oil 2-3%, calcium phosphate, potassium citrate and potassium chloride and the weight of the three are less than 1%. Compared with the prior art, the present invention has completely sugar-free soybean milk, and provides high-quality protein and some high-quality fat nutrients when combined with a ketogenic diet to treat epilepsy. , especially effective for some epilepsy patients whose seizures cannot be controlled by existing drugs, without unacceptable side effects.

Description

小儿无糖豆奶 Children's sugar-free soy milk

技术领域technical field

本发明涉及一种营养配方,特别是一种适用于生酮饮食疗法的营养配方。The invention relates to a nutritional formula, in particular to a nutritional formula suitable for ketogenic diet therapy.

背景技术Background technique

在医学上,对三种以上药物系统治疗后,仍然不能控制癫痫病情发作症状的癫痫称为药物难治性癫痫。癫痫长期、反复发作,可能严重影响病人生活质量,特别是造成小儿智力、语言、运动残疾,甚至因发作时外伤、溺水等意外事件而危及生命。目前在难治性癫痫治疗中,生酮饮食疗法效果肯定,且价格低、方便使用,但这类饮食疗法对碳水化合物的限制很严,国内众多豆奶生产厂商生产的豆奶中,碳水化合物含量较高,不能满足小儿生酮饮食治疗癫痫的要求。In medicine, epilepsy that cannot control the symptoms of epileptic seizures after systematic treatment with more than three drugs is called drug-refractory epilepsy. Long-term and recurrent epilepsy may seriously affect the quality of life of patients, especially causing intellectual, language, and motor disabilities in children, and even life-threatening due to accidents such as trauma and drowning during seizures. At present, in the treatment of refractory epilepsy, the ketogenic diet therapy is effective, and the price is low, and it is convenient to use. However, this type of diet therapy has strict restrictions on carbohydrates. The soy milk produced by many domestic soy milk manufacturers has a high carbohydrate content. It cannot meet the requirements of children's ketogenic diet for epilepsy.

发明内容Contents of the invention

本发明的目的是提供一种小儿无糖豆奶,要解决的技术问题是配合小儿生酮饮食治疗癫痫,补充蛋白质和部分优质脂肪类营养素。The purpose of the present invention is to provide a kind of sugar-free soybean milk for children. The technical problem to be solved is to treat epilepsy with children's ketogenic diet and supplement protein and some high-quality fat nutrients.

本发明采用以下技术方案:一种小儿无糖豆奶,该豆奶包含的重量比组分为:水87-88%、大豆蛋白4-5%、红花油2-3%、椰子油2-3%和大豆油2-3%。The present invention adopts the following technical solutions: a sugar-free soybean milk for children, the soybean milk contains the following components in weight ratio: 87-88% of water, 4-5% of soybean protein, 2-3% of safflower oil, 2-3% of coconut oil % and soybean oil 2-3%.

本发明的小儿无糖豆奶含有磷酸钙、枸掾酸钾和氯化钾,磷酸钙、枸掾酸钾和氯化钾三者重量的和小于1%。The sugar-free soybean milk for children of the present invention contains calcium phosphate, potassium citrate and potassium chloride, and the weight sum of the calcium phosphate, potassium citrate and potassium chloride is less than 1%.

本发明的小儿无糖豆奶每1000千卡含有10克水溶性膳食纤维。The sugar-free soybean milk for children of the present invention contains 10 grams of water-soluble dietary fiber per 1000 kcal.

本发明的大豆蛋白是大豆组织蛋白、大豆浓缩蛋白、大豆分离蛋白、蛋白粉或大豆乳清蛋白。The soybean protein of the present invention is soybean texture protein, soybean protein concentrate, soybean protein isolate, protein powder or soybean whey protein.

本发明与现有技术相比,豆奶完全无糖,配合生酮饮食治疗癫痫时,提供优质蛋白质和部分优质脂肪类营养素,使用和计算方便,还可同时配合其他营养素治疗癫痫患儿,疗效肯定,特别是对部分现有药物无法控制发作的癫痫病人有效,未产生不能接受的副作用。Compared with the prior art, the present invention has completely sugar-free soybean milk, and provides high-quality protein and some high-quality fat nutrients when combined with a ketogenic diet to treat epilepsy. , especially effective for some epilepsy patients whose seizures cannot be controlled by existing drugs, without unacceptable side effects.

具体实施方式Detailed ways

下面结合实施例对本发明作进一步详细说明。本发明的小儿无糖豆奶含有以下配方的重量百分比:水87-88%、大豆蛋白4-5%、红花油2-3%、椰子油2-3%、大豆油2-3%,磷酸钙、枸掾酸钾和氯化钾,三者之和<1%,水溶性膳食纤维为10g/1000Kcal。大豆蛋白是大豆组织蛋白、大豆浓缩蛋白、大豆分离蛋白、蛋白粉或大豆乳清蛋白。The present invention is described in further detail below in conjunction with embodiment. The sugar-free soybean milk for children of the present invention contains the following formula in weight percent: 87-88% of water, 4-5% of soybean protein, 2-3% of safflower oil, 2-3% of coconut oil, 2-3% of soybean oil, phosphoric acid The sum of calcium, potassium citrate and potassium chloride is less than 1%, and the water-soluble dietary fiber is 10g/1000Kcal. The soy protein is textured soy protein, soy protein concentrate, soy protein isolate, protein powder, or soy whey protein.

在人体内蛋白质主要维持小儿生长发育,肌肉发育。脂肪——红花油、椰子油和大豆油的主要作用是产生酮体:丙酮、乙酰乙酸、β-羟丁酸,所以又称酮源饮食。但该配方只能提供生酮饮食中部分脂肪,标准生酮饮食需另外补充脂肪类营养素。磷酸钙、枸掾酸钾和氯化钾用于补充部分电解质如钙、钾和氯。Protein in the human body mainly maintains the growth and development of children and muscle development. Fats—safflower oil, coconut oil, and soybean oil are mainly used to produce ketone bodies: acetone, acetoacetate, and beta-hydroxybutyrate, so they are also called ketone source diets. However, this formula can only provide part of the fat in the ketogenic diet, and the standard ketogenic diet needs to supplement additional fat nutrients. Calcium phosphate, potassium citrate, and potassium chloride are used to replenish some of the electrolytes such as calcium, potassium, and chloride.

本发明的小儿无糖豆奶提供优质蛋白质,而不影响高比例脂肪类食物作为生酮饮食的主要热量来源。也适合其他限制碳水化合物摄入疾病的辅助治疗。如:①碳水化合物吸收不良,②双糖酶缺乏;③半乳糖血症;④葡萄糖转运缺陷;⑤丙酮酸脱氢酶缺乏;⑥惊厥性疾病需配合生酮饮食治疗时使用。本发明的小儿无糖豆奶可采用以下方法制备:按重量比将市售医药用的大豆蛋白4-5%、红花油2-3%、椰子油2-3%、大豆油2-3%,磷酸钙、枸掾酸钾和氯化钾之和<1%,放入87-88%的纯净水中,搅拌半小时以上,静置半小时以上,消毒后再通过制奶设备装入密封罐中,采用金属罐包装,每罐384毫升。The sugar-free soymilk for children of the present invention provides high-quality protein without affecting the high-proportion fat food as the main calorie source of the ketogenic diet. It is also suitable for adjuvant treatment of other carbohydrate-restricted diseases. Such as: ① carbohydrate malabsorption, ② disaccharidase deficiency; ③ galactosemia; ④ glucose transport defect; ⑤ pyruvate dehydrogenase deficiency; The sugar-free soybean milk for children of the present invention can be prepared by the following method: 4-5% commercially available soybean protein, 2-3% safflower oil, 2-3% coconut oil, and 2-3% soybean oil , the sum of calcium phosphate, potassium citrate and potassium chloride < 1%, put it into 87-88% pure water, stir for more than half an hour, let it stand for more than half an hour, put it into a sealed tank through milk making equipment after disinfection Medium, packed in metal cans, 384ml per can.

本发明的小儿无糖豆奶为液态,呈奶状乳白色,乳香味。应该在受过专门训练的医生、护士或营养师指导下使用。服用方法为口服,根据生酮饮食治疗原则,由医生或营养师指导,按公斤体重计算每日需要量:蛋白质每天每公斤体重1-2克,热卡每天每公斤体重60-90千卡。配合小儿生酮饮食治疗癫痫的要求,至少服用3个月,疗效满意则可连续使用2-4年。对于其他限制碳水化合物摄入疾病的辅助治疗须在医生指导下服用。The sugar-free soymilk for children of the present invention is liquid, milky white and milky. It should be used under the guidance of a specially trained doctor, nurse or nutritionist. The method of administration is oral. According to the principle of ketogenic diet therapy, under the guidance of a doctor or a nutritionist, the daily requirement is calculated by kilogram of body weight: protein is 1-2 grams per kilogram of body weight per day, and calories are 60-90 kcal per kilogram of body weight per day. In line with the requirements of children's ketogenic diet for epilepsy, take it for at least 3 months, and if the curative effect is satisfactory, it can be used continuously for 2-4 years. Adjuvant treatment for other carbohydrate-restricted diseases must be taken under the guidance of a doctor.

实施例1:重量比配方:水87%、大豆组织蛋白4%、红花油2%、椰子油2%、大豆油2%,磷酸钙、枸掾酸钾和氯化钾,三者之和<1%。Embodiment 1: formula by weight: water 87%, soybean textured protein 4%, safflower oil 2%, coconut oil 2%, soybean oil 2%, calcium phosphate, potassium citrate and potassium chloride, the sum of the three <1%.

实施例2:重量比配方:水88%、大豆浓缩蛋白5%、红花油3%、椰子油3%、大豆油3%,磷酸钙、枸掾酸钾和氯化钾,三者之和<1%。Embodiment 2: formula by weight: water 88%, soybean protein concentrate 5%, safflower oil 3%, coconut oil 3%, soybean oil 3%, calcium phosphate, potassium citrate and potassium chloride, the sum of the three <1%.

实施例3:重量比配方:水87.5%、大豆分离蛋白4.5%、红花油2.5%、椰子油2.5%、大豆油2.5%,磷酸钙、枸掾酸钾和氯化钾,三者之和<1%。Embodiment 3: formula by weight: water 87.5%, soybean protein isolate 4.5%, safflower oil 2.5%, coconut oil 2.5%, soybean oil 2.5%, calcium phosphate, potassium citrate and potassium chloride, the sum of the three <1%.

食疗例1:姓名朱××,性别男,年龄7岁,住址广东省梅州市,病历:因反复癫痫反复发作7年就医。出生后1个月开始成串点头发作,5个月后转变为大发作,1-3次/天,先后给予卡马西平、苯妥因钠、苯巴比妥、妥泰、利必通、奥卡西平、氯硝西泮、强的松、德巴金和中药治疗失败。诊断为药物难治性癫痫。试用生酮饮食治疗,配合生酮饮食服用实施例1,3个月疗程,无副作用,服用后癫痫发作减少90%。Diet therapy example 1: Name Zhu ××, male, 7 years old, living in Meizhou City, Guangdong Province, medical history: 7 years of medical treatment due to recurrent epilepsy. A cluster of nodding seizures began 1 month after birth, and turned into grand seizures 5 months later. Carbamazepine, phenytoin sodium, phenobarbital, topane, Lamictal, and Treatment with oxcarbazepine, clonazepam, prednisone, Debakin and traditional Chinese medicine failed. A diagnosis of drug-refractory epilepsy was made. Trial ketogenic diet treatment, combined with ketogenic diet to take Example 1, 3 months of treatment, no side effects, 90% reduction in seizures after taking.

食疗例2:姓名何××,性别女,年龄5岁,住址安徽省安庆市,病历:因反复抽搐1年余就医。表现为成串痉挛发作2-5串/天,和大发作3-6次/天。先后给予德巴金、利必通、强的松、苯巴比妥、妥泰、硝西泮抗癫痫治疗失败。诊断为难治性癫痫。试用生酮饮食治疗,配合生酮饮食服用实施例2,1个月疗程,无副作用,服用后发作完全停止。Diet therapy example 2: name He ××, female, age 5 years old, address Anqing City, Anhui Province, medical records: due to repeated convulsions for more than 1 year to seek medical treatment. Shown as clusters of spasms 2-5 clusters/day, and grand mal seizures 3-6 times/day. The antiepileptic treatment with Debakin, Lamictal, Prednisone, Phenobarbital, Topane, and Nitrazepam failed successively. A diagnosis of intractable epilepsy was made. Trial ketogenic diet treatment, combined with ketogenic diet to take embodiment 2, 1 month course of treatment, no side effects, seizures completely stopped after taking.

食疗例3:姓名张××,性别男,年龄5岁,住址广东省东莞市,病历:因反复抽搐发作1年4个月就医。表现为大发作,4-6次/月。先后用得理多、德巴金、硝西泮、氯硝西泮、利必通、妥泰、曲莱、苯巴比妥治疗,每试用一种新药,2-3个月内有效,其后发作如前。诊断为药物难治性癫痫。试用生酮饮食治疗,配合生酮饮食服用实施例3,14个月疗程,无副作用,服用后癫痫发作减少65%。Diet therapy example 3: name Zhang XX, male, age 5 years old, address Dongguan City, Guangdong Province, medical records: because of repeated convulsions for 1 year and 4 months, he went to the doctor. Show as grand mal attack, 4-6 times/month. Successively treated with Delido, Debakin, Nitrazepam, Clonazepam, Lamictal, Topate, Trile, and Phenobarbital. Each trial of a new drug was effective within 2-3 months. Attack as before. A diagnosis of drug-refractory epilepsy was made. Trial ketogenic diet treatment, combined with ketogenic diet to take Example 3, 14 months of treatment, no side effects, 65% reduction in seizures after taking.

食疗例4:姓名郑××,性别女,年龄16岁,住址广东省深圳市,病历:因反复抽搐发作8年余就医。发作表现为部分性发作全身泛化,每次3-4分钟,每天1-2次。先后给予得理多、硝基安定、丙戊酸镁、利必通、曲莱、苯巴比妥抗癫痫治疗失败。诊断为药物难治性癫痫。试用生酮饮食治疗,配合酮食治疗服用实施例2,8个月疗程,无副作用,服用后发作减少75%。Diet therapy example 4: full name Zheng XX, gender female, age 16 years old, address Shenzhen City, Guangdong Province, medical records: because of repeated convulsions for more than 8 years to seek medical treatment. Seizures manifest as partial seizures and generalization of the whole body, 3-4 minutes each time, 1-2 times a day. The anti-epileptic treatment failed with Delidol, nitroazepam, magnesium valproate, Lamictal, Trilex, and phenobarbital successively. A diagnosis of drug-refractory epilepsy was made. Trial ketogenic diet therapy, combined with ketogenic diet therapy to take Example 2, 8 months of treatment, no side effects, after taking the seizures reduced by 75%.

食疗例5:姓名闻××,性别男,年龄3岁,住址浙江省德清县,病历:因反复点头发作1年余就医。表现为点头,可有下蹲,严重时意识丧失,每次数秒,2-9次/天。先后给予德巴金、硝西泮、卡马西平、妥泰治疗失败。诊断为难治性癫痫。试用生酮饮食治疗,配合酮食服用实施例2,3个月疗程,无副作用,服用后发作减少60%。Diet therapy example 5: name Wen XX, male gender, age 3 years old, address Deqing County, Zhejiang Province, medical history: because of repeated nodding attacks for more than 1 year to seek medical treatment. Manifested as nodding, there may be squatting, and in severe cases, loss of consciousness, every few seconds, 2-9 times per day. Successively given Debajin, nitrazepam, carbamazepine, topane treatment failed. A diagnosis of intractable epilepsy was made. Trial ketogenic diet treatment, combined with ketogenic diet to take Example 2, 3 months of treatment, no side effects, after taking the seizures reduced by 60%.

食疗例6:姓名李××,性别女,年龄2岁,住址北京市朝阳区,病历:反复点头样癫痫发作接近2年。生后不久开始成串点头痉挛发作,或单次痉挛发作。每天3-5次,每次1-20下。诊断婴儿痉挛症。先后给予促皮质素、德巴金、妥泰治疗失败。试用生酮饮食治疗,配合酮食服用实施例1,1个月疗程,无副作用,服用后发作减少70%。Diet therapy example 6: name Li XX, female, age 2 years old, address in Chaoyang District, Beijing, medical history: repeated nodding-like epileptic seizures for nearly 2 years. Clusters of nodding seizures, or single seizures, begin shortly after birth. 3-5 times a day, 1-20 times each time. Diagnose infantile spasms. Successively given corticotropin, Depakin, Topate treatment failed. Trial ketogenic diet treatment, combined with ketogenic diet to take embodiment 1, 1 month course of treatment, no side effects, after taking the seizures reduced by 70%.

食疗例7:姓名匡××,性别男,年龄3岁,住址吉林省长春市,病历:因反复抽搐8月余就医。成串点头发作,诊断为婴儿痉挛症。先后用促皮质素、妥泰、德巴金、曲莱、利必通、氯硝西泮治疗失败。试用生酮饮食治疗1个月,配合酮食服用实施例3,一个月疗程,无副作用,服用后发作减少80%。Dietary therapy example 7: Name Kuang ××, male gender, age 3 years old, address Changchun City, Jilin Province, medical records: because of repeated convulsions for more than 8 months to seek medical treatment. A cluster of nodding episodes, diagnosed as infantile spasms. Successive treatment with corticotropin, Topate, Debakin, Trile, Lamictal, and clonazepam failed. Trial ketogenic diet treatment for 1 month, combined with ketogenic diet to take embodiment 3 for a one-month course of treatment, no side effects, and seizures reduced by 80% after taking.

用生酮饮食治疗小儿癫痫,配合使用本发明的小儿无糖豆奶后,先后治疗10例难治性癫痫小儿,有效率达70%,没有产生不能接受的副作用。Using ketogenic diet to treat epilepsy in children, combined with the use of sugar-free soy milk for children of the present invention, successively treated 10 children with refractory epilepsy, with an effective rate of 70% and no unacceptable side effects.

Claims (2)

1. sugar-free soybean milk for infants, it is characterized in that: this soymilk is made up of following weight ratio ingredient: water 87-88%, soybean protein 4-5%, safflower oil 2-3%, coconut oil 2-3%, soybean oil 2-3%, calcium phosphate, potassium citrate and potassium chloride three weight and less than 1%; Described sugar-free soybean milk for infants contains 10 gram water-soluble dietary fibers for per 1000 kilocalories.
2. sugar-free soybean milk for infants according to claim 1 is characterized in that: described soybean protein is textured soybean protein, FSPC, soybean protein isolate, albumen powder or soybean whey protein.
CN2006101574066A 2006-12-06 2006-12-06 Children's sugar-free soy milk Expired - Fee Related CN1969641B (en)

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