CN1958018A - Method for preparing gel of treating wean rhinitis - Google Patents
Method for preparing gel of treating wean rhinitis Download PDFInfo
- Publication number
- CN1958018A CN1958018A CN 200510003259 CN200510003259A CN1958018A CN 1958018 A CN1958018 A CN 1958018A CN 200510003259 CN200510003259 CN 200510003259 CN 200510003259 A CN200510003259 A CN 200510003259A CN 1958018 A CN1958018 A CN 1958018A
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- China
- Prior art keywords
- parts
- medicinal liquid
- radix
- rhizoma
- rhinitis
- Prior art date
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Links
- 206010039083 rhinitis Diseases 0.000 title claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 14
- 235000015110 jellies Nutrition 0.000 claims abstract description 12
- 239000008274 jelly Substances 0.000 claims abstract description 12
- 239000000499 gel Substances 0.000 claims abstract description 8
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 6
- 229930006000 Sucrose Natural products 0.000 claims abstract description 6
- 238000009835 boiling Methods 0.000 claims abstract description 6
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 6
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 6
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 6
- 241000206501 Actaea <angiosperm> Species 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000009670 cang er zi wan Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 8
- 241001312219 Amorphophallus konjac Species 0.000 claims description 8
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims description 8
- 229920002581 Glucomannan Polymers 0.000 claims description 8
- 229920002752 Konjac Polymers 0.000 claims description 8
- 239000000679 carrageenan Substances 0.000 claims description 8
- 235000010418 carrageenan Nutrition 0.000 claims description 8
- 229940113118 carrageenan Drugs 0.000 claims description 8
- 229920001525 carrageenan Polymers 0.000 claims description 8
- 229940046240 glucomannan Drugs 0.000 claims description 8
- 239000000252 konjac Substances 0.000 claims description 8
- 235000010485 konjac Nutrition 0.000 claims description 8
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 6
- 230000002879 macerating effect Effects 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 241001180876 Saposhnikovia Species 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 241000545442 Radix Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract description 15
- 235000013399 edible fruits Nutrition 0.000 abstract description 4
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 241000229179 Ledebouriella Species 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960004106 citric acid Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 5
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
A medicinal gel for treating infantile rhinitis is prepared from 9 Chinese-medicinal materials including dahurian angelica root, ledebouriella root, cimicifuga rhizome, liquorice root, etc through respectively extracting their active components to obtain liquid, adding fruit jelly powder, immersing at 40 deg.C, stirring, adding the aqueous solution of cane sugar, potassium sorbate and citric acid, adding water, boiling and filling it in containers.
Description
Technical field
The invention belongs to medical technical field, relate in particular to a kind of preparation method of gel for the treatment of wean rhinitis.
Background technology
Rhinitis is child's common disease, this type of medicine mainly contains dosage forms such as granule, syrup, mixture, tablet, capsule in the market, all has certain defective, and mainly contain: syrup, mixture etc. mostly is bottled, can't once take after the uncork, easily there is the possibility of polluting in grow mold; Need use boiled water when granule is taken, tablet need pulverize to be taken, and occurs dysphagia etc. when capsule is taken and takes inconvenient phenomenon; Though the syrup mouthfeel is sweeter, also have the bitterness of medicine after all, though some medicine has sugar-coat, still there is bitterness the inside.Most of children is all mismatched when taking medicine, and therefore, the head of a family generally believes that taking medicine to the child is the comparatively thing of difficulty of part.
Summary of the invention
A kind of determined curative effect that the objective of the invention is to overcome above-mentioned shortcoming and provide, steady quality, the simple easy operating of production method carries and taking convenience, can not cause secondary pollution, the child take like a shot the preparation method of gel for the treatment of wean rhinitis.
Technical scheme of the present invention realizes in the following manner.
The preparation method of gel for the treatment of wean rhinitis of the present invention comprises the steps:
(1) take by weighing the following weight proportion raw material:
36.3 parts of Rhizoma Ligusticis, 36.3 parts of Radix Saposhnikoviaes, 36.3 parts of the Radixs Angelicae Dahuricae, 36.3 parts of Fructus Xanthii (deburring stir-fry), 36.3 parts of Folium Polygoni Tinctoriis, 36.3 parts of Herba Taraxacis, 24.2 parts of Rhizoma Cimicifugaes, 24.2 parts in Radix Glycyrrhizae;
(2) Radix Angelicae Dahuricae, Radix Saposhnikoviae are ground into fine powder for 19.4 parts, standby;
(3) Rhizoma Cimicifugae, Radix Glycyrrhizae are decocted with water secondary, 3 hours for the first time, 1 hour for the second time, filter, merging filtrate gets medicinal liquid one;
(4) with 16.9 parts of Radix Saposhnikoviaes, Rhizoma Ligustici, Fructus Xanthii with 70% alcohol heating reflux secondary, filter, merging filtrate reclaims ethanol, medicinal liquid two;
(5) medicinal liquid one and medicinal liquid two are merged, add above-mentioned thin part, mixing added 8～12 parts of warm macerating of jelly powder (40 ℃) 2 hours, heated and stirred is to dissolving, other gets 80 parts of sucrose, 1 part of potassium sorbate, citric acid and adds the suitable quantity of water heating for dissolving for 0.2 part, merges with above-mentioned solution, adds water to 900～1100 parts, abundant mixing, boiling sterilization, packing while hot, promptly.
Above-mentioned jelly powder is that weight ratio is a carrageenan: the mixture of Konjac glucomannan=1: 2.
The present invention compared with prior art, be through repetition test, be preferred for preparing the preferable prescription of effect of treatment infantile rhinitis medicine, at this prescription active ingredient curative effect of medication, bioavailability, technical specifications such as stability, optimizing the adjuvant gel-type vehicle is jelly powder, in conjunction with adopting scientific and reasonable technological design, medicine of the present invention is made food (fruit jelly) form that liked by the child, curative effect of medication not only, technical specifications such as bioavailability can not change, and the gel of making (fruit jelly) steady quality, be not prone to the easy elutriation that occurs of common fruit jelly and go out phenomenon, and the simple easy operating of production method, also can be deployed into various tastes as required.Carry and taking convenience, can not cause secondary pollution, thereby the child takes like a shot and can reach conscious effect of taking medicine, thoroughly solved child's problem of difficult of taking medicine, and Chinese medicine manufacturer is had extensive applicability.
The specific embodiment
Embodiment 1:
(1) take by weighing the following weight proportion raw material:
Rhizoma Ligustici 36.3g, Radix Saposhnikoviae 36.3g, Radix Angelicae Dahuricae 36.3g, Fructus Xanthii (deburring stir-fry) 36.3g, Folium Polygoni Tinctorii 36.3g, Herba Taraxaci 36.3g, Rhizoma Cimicifugae 24.2g, Radix Glycyrrhizae 24.2g;
Carrageenan 2.67g, Konjac glucomannan 5.33g;
(2) Radix Angelicae Dahuricae, Radix Saposhnikoviae 19.4g are ground into fine powder, standby;
(3) Rhizoma Cimicifugae, Radix Glycyrrhizae are decocted with water secondary, 3 hours for the first time, 1 hour for the second time, filter, merging filtrate gets medicinal liquid one;
(4) with Radix Saposhnikoviae 16.9g, Rhizoma Ligustici, Fructus Xanthii with 70% alcohol heating reflux secondary, filter, merging filtrate reclaims ethanol, medicinal liquid two;
(5) medicinal liquid one and medicinal liquid two are merged, add above-mentioned carefully part, mixing adds by carrageenan and Konjac glucomannan and mixed the jelly powder 8g warm macerating (40 ℃) that is made into 2 hours, heated and stirred is to dissolving, other gets sucrose 80g, potassium sorbate 1g, citric acid 0.2g adds the suitable quantity of water heating for dissolving, merges with above-mentioned solution, adds water to 900g, abundant mixing, boiling sterilization, packing while hot, promptly.
Embodiment 2:
1) take by weighing the following weight proportion raw material:
Rhizoma Ligustici 36.3g, Radix Saposhnikoviae 36.3g, Radix Angelicae Dahuricae 36.3g, Fructus Xanthii (deburring stir-fry) 36.3g, Folium Polygoni Tinctorii 36.3g, Herba Taraxaci 36.3g, Rhizoma Cimicifugae 24.2g, Radix Glycyrrhizae 24.2g;
Carrageenan 3g, Konjac glucomannan 6g;
(2) Radix Angelicae Dahuricae, Radix Saposhnikoviae 19.4g are ground into fine powder, standby;
(3) Rhizoma Cimicifugae, Radix Glycyrrhizae are decocted with water secondary, 3 hours for the first time, 1 hour for the second time, filter, merging filtrate gets medicinal liquid one;
(4) with Radix Saposhnikoviae 16.9g, Rhizoma Ligustici, Fructus Xanthii with 70% alcohol heating reflux secondary, filter, merging filtrate reclaims ethanol, medicinal liquid two;
(5) medicinal liquid one and medicinal liquid two are merged, add above-mentioned carefully part, mixing adds by carrageenan and Konjac glucomannan and mixed the jelly powder 9g warm macerating (40 ℃) that is made into 2 hours, heated and stirred is to dissolving, other gets sucrose 80g, potassium sorbate 1g, citric acid 0.2g adds the suitable quantity of water heating for dissolving, merges with above-mentioned solution, adds water to 1000g, abundant mixing, boiling sterilization, packing while hot, promptly.
Embodiment 3:
1) take by weighing the following weight proportion raw material:
Rhizoma Ligustici 36.3g, Radix Saposhnikoviae 36.3g, Radix Angelicae Dahuricae 36.3g, Fructus Xanthii (deburring stir-fry) 36.3g, Folium Polygoni Tinctorii 36.3g, Herba Taraxaci 36.3g, Rhizoma Cimicifugae 24.2g, Radix Glycyrrhizae 24.2g;
Carrageenan 4g, Konjac glucomannan 8g;
(2) Radix Angelicae Dahuricae, Radix Saposhnikoviae 19.4g are ground into fine powder, standby;
(3) Rhizoma Cimicifugae, Radix Glycyrrhizae are decocted with water secondary, 3 hours for the first time, 1 hour for the second time, filter, merging filtrate gets medicinal liquid one;
(4) with Radix Saposhnikoviae 16.9g, Rhizoma Ligustici, Fructus Xanthii with 70% alcohol heating reflux secondary, filter, merging filtrate reclaims ethanol, medicinal liquid two;
(5) medicinal liquid one and medicinal liquid two are merged, add above-mentioned carefully part, mixing adds by carrageenan and Konjac glucomannan and mixed the jelly powder 12g warm macerating (40 ℃) that is made into 2 hours, heated and stirred is to dissolving, other gets sucrose 80g, potassium sorbate 1g, citric acid 0.2g adds the suitable quantity of water heating for dissolving, merges with above-mentioned solution, adds water to 1100g, abundant mixing, boiling sterilization, packing while hot, promptly.
Claims (2)
1, a kind of preparation method of gel for the treatment of wean rhinitis comprises the steps:
(1) take by weighing the following weight proportion raw material:
36.3 parts of Rhizoma Ligusticis, 36.3 parts of Radix Saposhnikoviaes, 36.3 parts of the Radixs Angelicae Dahuricae, 36.3 parts of Fructus Xanthii (deburring stir-fry), 36.3 parts of Folium Polygoni Tinctoriis, 36.3 parts of Herba Taraxacis, 24.2 parts of Rhizoma Cimicifugaes, 24.2 parts in Radix Glycyrrhizae;
(2) Radix Angelicae Dahuricae, Radix Saposhnikoviae are ground into fine powder for 19.4 parts, standby;
(3) Rhizoma Cimicifugae, Radix Glycyrrhizae are decocted with water secondary, 3 hours for the first time, 1 hour for the second time, filter, merging filtrate gets medicinal liquid one;
(4) with 16.9 parts of Radix Saposhnikoviaes, Rhizoma Ligustici, Fructus Xanthii with 70% alcohol heating reflux secondary, filter, merging filtrate reclaims ethanol, medicinal liquid two;
(5) medicinal liquid one and medicinal liquid two are merged, add above-mentioned thin part, mixing added 8～12 parts of 40 ℃ of warm macerating of jelly powder 2 hours, heated and stirred is to dissolving, other gets 80 parts of sucrose, 1 part of potassium sorbate, the acid of structure rafter adds the suitable quantity of water heating for dissolving for 0.2 part, merges with above-mentioned solution, adds water to 900～1100 parts, abundant mixing, boiling sterilization, packing while hot, promptly.
2, the preparation method of gel for the treatment of wean rhinitis as claimed in claim 1, wherein jelly powder is that weight ratio is a carrageenan: the mixture of Konjac glucomannan=1: 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510003259 CN1958018A (en) | 2005-11-03 | 2005-11-03 | Method for preparing gel of treating wean rhinitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510003259 CN1958018A (en) | 2005-11-03 | 2005-11-03 | Method for preparing gel of treating wean rhinitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1958018A true CN1958018A (en) | 2007-05-09 |
Family
ID=38069970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510003259 Pending CN1958018A (en) | 2005-11-03 | 2005-11-03 | Method for preparing gel of treating wean rhinitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1958018A (en) |
-
2005
- 2005-11-03 CN CN 200510003259 patent/CN1958018A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |