CN1660260A - Effervescence grains of reducing fever and relieving a cough for infant and preparation method - Google Patents
Effervescence grains of reducing fever and relieving a cough for infant and preparation method Download PDFInfo
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- CN1660260A CN1660260A CN 200410081464 CN200410081464A CN1660260A CN 1660260 A CN1660260 A CN 1660260A CN 200410081464 CN200410081464 CN 200410081464 CN 200410081464 A CN200410081464 A CN 200410081464A CN 1660260 A CN1660260 A CN 1660260A
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- clearing
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- antitussive
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- 206010037660 Pyrexia Diseases 0.000 title claims description 8
- 206010011224 Cough Diseases 0.000 title abstract description 10
- 238000002360 preparation method Methods 0.000 title description 4
- 239000003814 drug Substances 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000002245 particle Substances 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims description 21
- 230000000954 anitussive effect Effects 0.000 claims description 17
- 229940124584 antitussives Drugs 0.000 claims description 17
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 17
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 230000002378 acidificating effect Effects 0.000 claims description 11
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 8
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 8
- 239000000945 filler Substances 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 7
- 229930006000 Sucrose Natural products 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 239000010231 banlangen Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 229960004793 sucrose Drugs 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 241000202807 Glycyrrhiza Species 0.000 claims description 2
- 241000207929 Scutellaria Species 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 235000019820 disodium diphosphate Nutrition 0.000 claims description 2
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 claims description 2
- RRPFCKLVOUENJB-UHFFFAOYSA-L disodium;2-aminoacetic acid;carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O.NCC(O)=O RRPFCKLVOUENJB-UHFFFAOYSA-L 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 claims description 2
- 235000018341 sodium sesquicarbonate Nutrition 0.000 claims description 2
- 235000010265 sodium sulphite Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 claims description 2
- 235000009827 Prunus armeniaca Nutrition 0.000 abstract description 2
- 244000018633 Prunus armeniaca Species 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 241000218671 Ephedra Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- 208000000059 Dyspnea Diseases 0.000 description 4
- 206010013975 Dyspnoeas Diseases 0.000 description 4
- 206010068319 Oropharyngeal pain Diseases 0.000 description 4
- 201000007100 Pharyngitis Diseases 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 230000001754 anti-pyretic effect Effects 0.000 description 3
- 239000002221 antipyretic Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 208000021760 high fever Diseases 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 208000010540 rapid respiration Diseases 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 241001465251 Ephedra sinica Species 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000334154 Isatis tinctoria Species 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 241000219784 Sophora Species 0.000 description 1
- 241000123725 Sophora tonkinensis Species 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 230000000410 anti-febrile effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 208000008203 tachypnea Diseases 0.000 description 1
- 206010043089 tachypnoea Diseases 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of effervescent particles for treating infantile cold and cough is prepared from auxiliary and 7 Chinese-medicinal materials including ephedra, bitter apricot kernel, gypsum, liquorice root. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to a kind of is the medicine of preparation of raw material with the Chinese herbal medicine, particularly belongs to the effervescent granule of heat clearing away and cough-relieving.
Background technology
Fever caused by exogenous pathogens is the symptom of common respiratory tract disease, is common in pediatric patient.Fever caused by exogenous pathogens can influence patient's life and normal development.China has accumulated rich experience over thousands of years aspect treatment infantile fever caused by exogenous pathogens disease, and traditional traditional Chinese medical science and herbalist have many prescriptions.Commercially available " infantile heat-clearing and antitussive oral liquid " is exactly one of them kind.Some be used for the application of antipyretic Chinese herbal medicine formula patent of invention, for example No. 95106240.9 " Antifebrile oral liquor ", No. 00121310.5 " a kind of antipyretic and preparation method thereof ", No. 02159199.7 " a kind of children's antipyretic medicines " etc. are arranged in recent years.
The medicament of above-mentioned all treatment fever caused by exogenous pathogens all has certain effect.But doctors are still exploring better prescription, to alleviate the patient suffering as early as possible, to recover patient health.
Summary of the invention
It is the clearing and antitussive effervescent granule that raw material is made that purpose of the present invention just is to provide a kind of Chinese medicine that adopts, and makes the pediatric patient can be in shorter time, and symptom is alleviated and disappeared.
Solution of the present invention is based on commercially available " infantile heat-clearing and antitussive oral liquid ", with reference to inventor's medical practice experience, takes the novel form of release for making things convenient for pediatric patient.
Infantile heat-clearing and antitussive effervescent granule of the present invention is made by crude drug and adjuvant, and wherein the component of crude drug and consumption thereof (consumption is a weight portion) are as follows:
Herba Ephedrae 90 Semen Armeniacae Amarums 120 Gypsum Fibrosum 270 Radix Glycyrrhizaes 90 Radix Scutellariaes 180 Radix Isatidis 180
Rhizoma Menispermi 90
The quality proportioning of the mixture of said medicine and adjuvant is:
Medicinal mixture 5%～80%,
Adjuvant 20%～95%
Adjuvant wherein can be an acidic excipient, comprises citric acid, tartaric acid, sodium dihydrogen phosphate, Sodium Acid Pyrophosphate, sodium sulfite etc., and basic auxiliary, comprises sodium bicarbonate, sodium carbonate, potassium bicarbonate, sodium glycine carbonate, sodium sesquicarbonate etc.; Also need add filler soluble starch, cane sugar powder.
The quality proportioning of used acidic excipient and basic auxiliary is:
Acidic excipient 40%～50%
Basic auxiliary 50%～60%.
In the said herbal medicine, Herba Ephedrae (Ephedra sinica), warm in nature, acrid in the mouth is bitter, diaphoresis is arranged, relieving asthma, the effect of diuretic, cold table reality that can cure the wound, fever with chills, headache nasal obstruction, cough and asthma (seeing 2221 pages of the new medical college volumes in Jiangsu " Chinese medicine voluminous dictionary "); Semen Armeniacae Amarum, i.e. Semen Armeniacae Amarum, warm in nature for the core of the dry seed of rosaceous plant Fructus Pruni (Prunusarmeniaca), bitter in the mouth, poisonous, the effect of expelling phlegm for arresting cough is arranged, relievining asthma can be controlled diseases (seeing " Chinese medicine voluminous dictionary " 1100 pages) such as exogenous cough, dyspnea with fullness of the chest, sore throat; Gypsum Fibrosum (Cypsum), acrid-sweet flavor, cold in nature, the effect that has expelling pathogenic factors from muscles for clearing heat, relieving restlessness to quench the thirst can control that the calentura high fever does not move back, vexed coma, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration (seeing " Chinese medicine voluminous dictionary " 592 pages); Radix Glycyrrhizae (Glycyrrhizauralensis), flat, the sweet in the mouth of property has and middle emergency, lung moistening, antidotal effect, can control laryngopharynx swelling and pain, the lung diseases such as cough (seeing " Chinese medicine voluminous dictionary " 567 pages) of withering; Radix Scutellariae (Scutellaria baicalensis), cold in nature, bitter in the mouth has the effect of heat clearing and damp drying, eliminating fire and detoxication, removing heat from blood heat extraction, can control high fever excessive thirst, cough due to lung-heat, damp-heat dysentery (seeing " Chinese medicine voluminous dictionary " 2017 pages); Radix Isatidis (Isatis tinctoria), cold in nature, bitter in the mouth has the effect of heat clearing away, detoxifcation, removing heat from blood, can control influenza, pneumonia (seeing " Chinese medicine voluminous dictionary " 1250 pages); Rhizoma Menispermi, promptly Radix Sophorae Tonkinensis is the root of leguminous plant root of subprostrate sophora (Sophora subprostrata), bitter in the mouth is cold in nature, relieves inflammation or internal heat, detoxifies, detumescence, analgesic effect, can soothe sore throat, sore throat, dyspnea with fullness of the chest heat syndrome cough see " Chinese medicine voluminous dictionary " 182 pages).
The preparation method of infantile heat-clearing and antitussive effervescent granule of the present invention comprises:
(1) gets the decocting that Herba Ephedrae, Gypsum Fibrosum add 8～12 times in proportion and boil 10～120min, add in proportion again and fry the Semen Armeniacae Amarum of processing and Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis, Rhizoma Menispermi in advance, decocted 1～4 hour; The decocting that adds 6～10 times of doses for the 2nd time boiled 0.5～3 hour, merged decoction liquor;
(2) decoction liquor with above-mentioned merging filters, and filtrate decompression is concentrated into 200～2000ml, leaves standstill after 6～36 hours to filter, and filtrate is condensed into the extractum that density is 1.05～1.35 (50～60 ℃), and is standby;
(3) gained extractum is divided into two parts, gets a acidic excipient and the filler of adding, another part adds basic auxiliary and filler, and then the mixed soft material of difference, granulate oven dry, hybrid particles, granulate, pack promptly makes the infantile heat-clearing and antitussive effervescent granule after the assay was approved.
The preferred processing condition of above method for making is:
The water yield that step (1) adds for the first time is 10 times of dose; Herba Ephedrae and Gypsum Fibrosum decocted 0.5 hour earlier; Add that decocting time is 2.0 hours behind the remaining medicine, amount of water is 8 times of dose for the second time, decocts 1 hour the best;
Step (2) is evaporated to 600ml and is advisable, and leaves standstill 24 hours the bests;
Step (3) acidic excipient selects for use citric acid, basic auxiliary to select for use sodium bicarbonate, filler to add sucrose the best.
Infantile heat-clearing and antitussive effervescent granule usage of the present invention is for oral administration, and the patient obeys 4 every day, and in crude drug, 1 years old with interior each 2.5g; 1～3 year old each 5g; 4～6 years old each 7.5g; 7～14 years old each 10g; Take with the eliminating cold for resuscitation water dissolution.
Infantile heat-clearing and antitussive effervescent granule of the present invention is based on the infantile heat-clearing and antitussive oral liquid, further develops, and it has good heat clearing away, lung qi dispersing, relievings asthma, the sore-throat relieving effect.Be used for diseases such as Sheng, fever with chills, cough expectorant Huang, tachypnea dyspnea with rapid respiration, xerostomia hoarseness, laryngopharynx swelling and pain in children's exogenous, the evil poison clinically.This product is taken safety, effective, convenient, and medicine stability is good.
The specific embodiment
Embodiment prepares the infantile heat-clearing and antitussive effervescent granule by the following method:
(1) gets Herba Ephedrae 90g, Gypsum Fibrosum 270g and add the 3600ml clear water and decoct 10～120min, add again and fry the Semen Armeniacae Amarum 120g that processs and Radix Glycyrrhizae 90g, Radix Scutellariae 180g, Radix Isatidis 180g, Rhizoma Menispermi 90g in advance, decocted 2 hours; The decocting that adds 8 times of doses for the 2nd time boiled 1 hour, merged decoction liquor;
(2) decoction liquor with above-mentioned merging filters, and filtrate decompression is concentrated into 600ml, leaves standstill after 24 hours to filter, and filtrate is condensed into the extractum that density is 1.05～1.35 (50～60 ℃), and is standby;
(3) gained extractum is divided into two parts, get a acidic excipient citric acid 90g of adding and sucrose 350g, another part adds basic auxiliary sodium bicarbonate 108g and sucrose 350g, mixed then soft material is granulated, oven dry, hybrid particles, granulate, pack promptly makes infantile heat-clearing and antitussive effervescent granule 1000g (net weight) after the assay was approved.
Claims (5)
1 infantile heat-clearing and antitussive effervescent granule is made by crude drug and adjuvant, it is characterized in that the component of crude drug and consumption (consumption is a weight portion) thereof are as follows:
Herba Ephedrae 90 Semen Armeniacae Amarums 120 Gypsum Fibrosum 270 Radix Glycyrrhizaes 90 Radix Scutellariaes 180 Radix Isatidis 180
Rhizoma Menispermi 90
The quality proportioning of the mixture of said medicine and adjuvant is:
Medicinal mixture 5%～80%,
Adjuvant 20%～95%.
2 according to the described infantile heat-clearing and antitussive effervescent granule of claim 1, it is characterized in that adjuvant wherein can be an acidic excipient, comprise citric acid, tartaric acid, sodium dihydrogen phosphate, Sodium Acid Pyrophosphate, sodium sulfite etc., and basic auxiliary, comprise sodium bicarbonate, sodium carbonate, potassium bicarbonate, sodium glycine carbonate, sodium sesquicarbonate etc.; Add filler soluble starch, cane sugar powder again.
3 according to claim 1 or 2 described infantile heat-clearing and antitussive effervescent granules, it is characterized in that the quality proportioning of used acidic excipient and basic auxiliary is:
Acidic excipient 40%～50%
Basic auxiliary 50%～60%.
4 according to the bring down a fever method for making of effervescent granule of the described children's Chai Gui of claim 1, and its feature comprises:
(1) gets the decocting that Herba Ephedrae, Gypsum Fibrosum add 8～12 times in proportion and boil 10～120min, add in proportion again and fry the Semen Armeniacae Amarum of processing and Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis, Rhizoma Menispermi in advance, decocted 1～4 hour; The decocting that adds 6～10 times of doses for the 2nd time boiled 0.5～3 hour, merged decoction liquor;
(2) decoction liquor with above-mentioned merging filters, and filtrate decompression is concentrated into 200～2000ml, leaves standstill after 6～36 hours to filter, and filtrate is condensed into the extractum that density is 1.05～1.35 (50～60 ℃), and is standby;
(3) gained extractum is divided into two parts, gets a acidic excipient and the filler of adding, another part adds basic auxiliary and filler, and then the mixed soft material of difference, granulate oven dry, hybrid particles, granulate, pack promptly makes the infantile heat-clearing and antitussive effervescent granule after the assay was approved.
5 method for makings according to the described infantile heat-clearing and antitussive effervescent granule of claim 1 is characterized in that the preferred processing condition of above method for making is:
The water yield that step (1) adds for the first time is 10 times of dose; Herba Ephedrae and Gypsum Fibrosum decocted 0.5 hour earlier; Add that decocting time is 2.0 hours behind the remaining medicine, amount of water is 8 times of dose for the second time, decocts 1 hour the best;
Step (2) is evaporated to 600ml and is advisable, and leaves standstill 24 hours the bests;
Step (3) acidic excipient selects for use citric acid, basic auxiliary to select for use sodium bicarbonate, filler to add sucrose the best.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410081464 CN1660260A (en) | 2004-12-09 | 2004-12-09 | Effervescence grains of reducing fever and relieving a cough for infant and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410081464 CN1660260A (en) | 2004-12-09 | 2004-12-09 | Effervescence grains of reducing fever and relieving a cough for infant and preparation method |
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| Publication Number | Publication Date |
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| CN1660260A true CN1660260A (en) | 2005-08-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 200410081464 Pending CN1660260A (en) | 2004-12-09 | 2004-12-09 | Effervescence grains of reducing fever and relieving a cough for infant and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011037734A (en) * | 2009-08-07 | 2011-02-24 | Rohto Pharmaceutical Co Ltd | Solid medical composition |
| JP2011042649A (en) * | 2009-07-24 | 2011-03-03 | Rohto Pharmaceutical Co Ltd | Pharmaceutical composition containing chinese herbal extract |
| CN101537056B (en) * | 2008-03-19 | 2011-08-17 | 北京亚东生物制药有限公司 | Preparation method of traditional Chinese medicine preparation for treating children with external respiratory tract infection |
| CN101352494B (en) * | 2008-06-17 | 2011-08-24 | 浙江泰利森药业有限公司 | Children's granules for clearing heat and suppressing cough and preparation method thereof |
| CN102579632A (en) * | 2012-04-09 | 2012-07-18 | 河南百年康鑫药业有限公司 | Preparation method of concentrated heat-clearing and cough-relieving oral solution for children |
| CN102266403B (en) * | 2008-03-19 | 2012-08-15 | 北京亚东生物制药有限公司 | Traditional Chinese preparation for treating upper respiratory tract infection in children |
| JP2014224161A (en) * | 2014-09-10 | 2014-12-04 | ロート製薬株式会社 | Solid pharmaceutical composition |
-
2004
- 2004-12-09 CN CN 200410081464 patent/CN1660260A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537056B (en) * | 2008-03-19 | 2011-08-17 | 北京亚东生物制药有限公司 | Preparation method of traditional Chinese medicine preparation for treating children with external respiratory tract infection |
| CN102266403B (en) * | 2008-03-19 | 2012-08-15 | 北京亚东生物制药有限公司 | Traditional Chinese preparation for treating upper respiratory tract infection in children |
| CN101352494B (en) * | 2008-06-17 | 2011-08-24 | 浙江泰利森药业有限公司 | Children's granules for clearing heat and suppressing cough and preparation method thereof |
| JP2011042649A (en) * | 2009-07-24 | 2011-03-03 | Rohto Pharmaceutical Co Ltd | Pharmaceutical composition containing chinese herbal extract |
| JP2011037734A (en) * | 2009-08-07 | 2011-02-24 | Rohto Pharmaceutical Co Ltd | Solid medical composition |
| CN102579632A (en) * | 2012-04-09 | 2012-07-18 | 河南百年康鑫药业有限公司 | Preparation method of concentrated heat-clearing and cough-relieving oral solution for children |
| JP2014224161A (en) * | 2014-09-10 | 2014-12-04 | ロート製薬株式会社 | Solid pharmaceutical composition |
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