CN1883445A - Multifunctional enzyme-supplemented colorful toothpaste and preparation method thereof - Google Patents

Abstract

Disclosed is a multifunctional color bar enzymatic toothpaste and preparation method. The toothpaste is formed by one color regulation cream which containing chemical medicament additive and biologic enzyme activator, and multi-color cream containing biologic enzyme and biologic enzyme stabilizer. The preparation method is separately preparing regulation cream and enzyme cream and canning to color bar toothpaste. Functions of the toothpaste is to prevention and cure oral problem such as preventing and curing decayed tooth, diminishing inflammation, sterilization, desensitization, eliminating halitosis and whitening teeth. Simultaneously the toothpaste employing stabilizer and color bar to ensure the stability, and effectively exerting biology function of enzyme in release process by adding definite activator.

Description

Multifunctional color bar enzyme toothpaste and preparation method thereof

technical field

The invention relates to a toothpaste, in particular to a colored strip toothpaste containing multiple biological enzymes.

Background technique

Among oral diseases, dental caries and periodontal disease are the main causes of tooth loss. Research results have shown that cariogenic Streptococcus mutans can produce glucan when grown on a medium containing sucrose, and the enrichment phenomenon of Streptococcus mutans was observed at the same time. Glucan is a viscous colloidal substance that can gather a variety of pathogenic bacteria and form plaque on teeth. The organic acids produced by acid-producing pathogenic bacteria can cause decalcification of tooth enamel, and then form dental caries.

In order to prevent and treat dental caries, two methods are generally used in the prior art, one is pharmaceutical preparations, but there are many unfavorable factors such as drug resistance, and the other is the use of biologically active preparations. In recent years, many scientists and medical workers have added a variety of compound enzyme preparations to toothpaste, which has achieved good results in the treatment of plaque and dental caries.

Toothpaste, a daily necessity, has gone through decades of changes. With the improvement of human living standards, everyone has higher and higher requirements for toothpaste. With the maturity of biotechnology, bio-enzyme toothpaste has become a hot research.

At present, foreign countries, especially Japan, have done a lot of research work on the research of enzyme-containing biological toothpaste, and have also published many related patents, such as Japanese patents JP200063251, JP2001302481, JP2001342123, JP200220254, JP96310931, JP97 25221, etc. disclose some enzyme-containing toothpaste . And enzymatic toothpaste is still in the exploratory stage in my country, and some patents of enzymatic toothpaste have also appeared in China at present, as CN 1366875A, CN 1720891A, CN 1688282A, CN 1190579A. Based on the combination of toothpastes containing enzymes at home and abroad, generally speaking, the types of enzymes contained in toothpaste are relatively single, and their functions are relatively single, and the activity and stability of enzymes cannot be well guaranteed.

The stability of biological enzymes is relatively poor, and various biological enzymes have specific conditions for their stable existence. Adding biological enzymes to toothpaste not only ensures the stability of the toothpaste paste, but also ensures the activity and stability of biological enzymes. Most of the existing enzyme-containing toothpastes are mixed with various raw materials and biological enzymes, and then canned In the hose, since the conditions for the stable existence of various biological enzymes are not nearly the same, it is difficult to ensure the stable existence of various enzymes when adding multiple biological enzymes to a single paste. However, the color bar toothpaste technology that occurs at present is novel in appearance and attractive in appearance, but does not highlight the uniqueness of its functional design.

Contents of the invention

The purpose of the present invention is to provide a multi-functional color bar enzyme toothpaste and its preparation method, which not only has a novel and beautiful appearance, ensures the stability of the toothpaste paste, but also ensures the activity and stability of biological enzymes, so as to achieve multiple The effect of preventing and treating oral diseases.

The purpose of the present invention is achieved through the following technical solutions:

A multi-functional color bar enzyme toothpaste, characterized in that the toothpaste is composed of a color-adjusting paste and multiple-color enzyme-containing pastes, and the regulating paste contains chemical drug additives and bio-enzyme activation agent, the enzyme-containing paste contains biological enzymes and biological enzyme stabilizers, and the components and weight percentages of the regulating paste are:

Moisturizer 20～73%

Friction agent 15～50%

Thickener 1～1.7%

Surfactant 1.7～2.5%

Fragrance 0.8～1.2%

Water 8～35%

Saccharin 0.1～0.3%

Pigment 0～0.5%

Polyethylene glycol 0～6%

Chemical drug additives 0.03～5%

Menthol 0～0.1%

Sodium dihydrogen phosphate 0～0.5%

Titanium dioxide 0～1%

Biological enzyme activator 0.1～1%

The components and weight percent content of each enzyme-containing paste are:

Moisturizer 20～73%

Friction agent 15～50%

Thickener 1～1.7%

Surfactant 1～6%

Fragrance 0.8～1.2%

Water 8～35%

Saccharin 0.1～0.3%

Pigment 0～0.5%

Polyethylene glycol 0～6%

Biological enzymes 0.01～2%

Menthol 0～0.1%

Sodium dihydrogen phosphate 0.1～0.5%

Titanium dioxide 0～1%

Biological enzyme stabilizer 0.1～4%

Described biological enzyme is dextranase, lysozyme, protease, glucose oxidase, amylase, superoxide dismutase, catalase, lipase, papain or pineapple enzyme; Described amylase, glucose One or more of sugar oxidase, dextranase, and papain are added to a color paste; one or more of the lysozyme, protease, catalase, and pineapple enzyme are added In another color paste; one or both of the superoxide dismutase and lipase are added to other color paste; the chemical drug additives are sodium monofluorophosphate, fluoride Sodium, trisodium phosphate, sodium pyrophosphate, potassium pyrophosphate, potassium nitrate, urea, sodium phytate, strontium chloride, Yujiechun, sodium copper chlorophyllin, sodium chloride, zinc citrate, potassium citrate, glycerophosphate One or more of calcium. The biological enzyme stabilizer of the present invention is one or more of pyrithione and its salt, Tween, Span, peptone, gelatin; the biological enzyme activator is manganese chloride, calcium chloride , magnesium chloride, taurine, glycine, aspartic acid in one or more.

The humectant of the present invention is one or more of sorbitol, glycerin, propylene glycol and diethylene glycol. The surfactant is sodium lauryl sulfate, sodium lauryl sarcosinate, imidazoline series amphoteric surfactant, polyoxyethylene alkyl ether phosphoric acid and its salt, dipolyoxyethylene alkyl ether phosphoric acid One or more of its salts and polyoxyethylene alkyl ether tripolyphosphoric acid. The friction agent is one or more of calcium carbonate, silicon dioxide, aluminum hydroxide, and calcium hydrogen phosphate. The thickener is one or more of sodium carboxymethylcellulose, carrageenan, HEC, xanthan gum, alginate, carbomer, and magnesium aluminum silicate.

The present invention provides a kind of preparation method of above-mentioned multi-functional color bar enzyme toothpaste, it is characterized in that the method comprises the following steps:

1) Prepare the regulating paste: according to the weight percentage of the regulating paste, first mix the sorbitol in the humectant, the water and the water-soluble raw materials and chemical drug additives in the components, and then add the glycerin in the moisturizing agent , a mixture of propylene glycol or diethylene glycol and a thickener, and finally add chemical drug additives that are not easily soluble in water, biological enzyme activators, friction agents, surfactants and other raw materials that are not easily soluble in water to make a color paste body;

2) Prepare enzyme-containing pastes of different colors: divide the biological enzymes into the following three categories with the pH range in which the biological enzymes stably exist:

a. Amylase, glucose oxidase, dextranase and papain,

b. Lysozyme, protease, catalase and bromelain,

c. superoxide dismutase and lipase;

The above three types of biological enzymes are respectively made into enzyme-containing pastes of different colors. The preparation process of each enzyme-containing paste is the same, and the specific preparation process is as follows: according to the weight percentage of the enzyme-containing paste, the Mix sorbitol, water and water-soluble raw materials evenly, then add the mixture of glycerin, propylene glycol or diethylene glycol in the humectant, thickener and biological enzyme; finally add biological enzyme stabilizer, friction agent, surfactant And other raw materials that are not easily soluble in water, stir evenly and degas to make enzyme-containing paste;

3) Filling: The prepared conditioning paste and the enzyme-containing paste are filled together into a toothpaste tube to make a multi-functional color bar enzyme toothpaste.

Compared with the prior art, the present invention has the following advantages and prominent effects: in design, the multi-functional color bar enzyme toothpaste contains enzyme-containing paste and regulating paste, which can effectively ensure the presence of various enzymes in the toothpaste The stable requirements and the best state of enzyme release overcome the drawbacks of the existing enzyme-added toothpaste, and can give people a good appearance. In terms of function, the joint action of various biological enzymes and chemical drug additives in the toothpaste makes this kind of multi-enzyme toothpaste with multiple prevention and treatment effects on oral problems, such as preventing dental caries, anti-inflammatory and sterilization, desensitization, fresh breath, whitening teeth and other functions.

Detailed ways

The toothpaste is composed of two types of pastes, one of which is added with chemical drug additives and biological enzyme activators, which is called regulating paste; the other type of paste is added with biological enzymes and biological enzyme stabilizers, called It is an enzyme paste. Then a color-adjusting paste and one or more colors of enzyme-containing paste are filled together to become a colored bar toothpaste. The composition and weight percentage content of described adjustment paste are:

Moisturizer (sorbitol, glycerin, propylene glycol, diethylene glycol): 20-73%

Friction agent (calcium carbonate, silicon dioxide, aluminum hydroxide, calcium hydrogen phosphate): 15-50%

Thickener (sodium carboxymethyl cellulose, carrageenan, HEC, xanthan gum, alginate, carbo, magnesium aluminum silicate, etc.): 1～1.7%

Surfactant (sodium lauryl sulfate, sodium lauryl sarcosinate, imidazoline amphoteric surfactant, polyoxyethylene alkyl ether phosphoric acid and its salt, dipolyoxyethylene alkyl ether phosphoric acid and its salt , polyoxyethylene alkyl ether tripolyphosphoric acid, etc.): 1.7～2.5%

Flavor: 0.8～1.2%

Water: 8~35%

Saccharin: 0.1～0.3%

Pigment (bright blue, quinoline yellow, lemon yellow, yellow 6#, green 6#, red 28#, red 43#, red 40#): 0～0.5%

Polyethylene glycol: 0~6%

Chemical drug additives: 0.03-5%

Menthol: 0～0.1%

Sodium dihydrogen phosphate: 0~0.5%

Titanium dioxide: 0~1%

Biological enzyme activator: 0.1～1%

Another type of enzyme-containing paste is made into pastes of different colors according to the stability requirements of the enzyme. The components and weight percentages of each paste are:

Moisturizer (sorbitol, glycerin, propylene glycol, diethylene glycol): 20-73%

Friction agent (calcium carbonate, silicon dioxide, aluminum hydroxide, calcium hydrogen phosphate): 15-50%

Thickener (sodium carboxymethyl cellulose, carrageenan, HEC, xanthan gum, alginate, carbo, magnesium aluminum silicate, etc.): 1～1.7%

Surfactant (sodium lauryl sulfate, sodium lauryl sarcosinate, imidazoline amphoteric surfactant, polyoxyethylene alkyl ether phosphoric acid and its salt, dipolyoxyethylene alkyl ether phosphoric acid and its salt , polyoxyethylene alkyl ether tripolyphosphoric acid, etc.): 1 to 6%

Flavor: 0.8～1.2%

Water: 8~35%

Saccharin: 0.1～0.3%

Pigment (bright blue, quinoline yellow, lemon yellow, yellow 6#, green 6#, red 28#, red 43#, red 40#): 0～0.5%

Polyethylene glycol: 0~6%

Menthol: 0～0.1%

Sodium dihydrogen phosphate: 0~0.5%

Titanium dioxide: 0~1%

Biological enzyme stabilizer: 0.1~4%

Biological enzyme: 0.01～2%

The biological enzyme added in the toothpaste is lysozyme, dextranase, protease, amylase, glucose oxidase, superoxide dismutase, catalase, lipase, papain or pineapple enzyme, and the above-mentioned biological enzyme is based on its The requirements for stable existence conditions are classified, mainly based on the pH range of the stable existence of biological enzymes, which are divided into three categories: 1) The pH range is 3.0-7.0: amylase, glucose oxidase, dextranase, papain , 2) pH range of 6-7: lysozyme, protease, catalase, bromelain, 3) pH range of 6-10.5: superoxide dismutase, lipase. Chemical drug additives can be sodium monofluorophosphate, sodium fluoride, sodium pyrophosphate, potassium pyrophosphate, potassium nitrate, urea, sodium phytate, strontium chloride, Yujiechun, sodium copper chlorophyllin, sodium chloride, citric acid One or more of zinc, potassium citrate, and calcium glycerophosphate, by adding biological enzymes and chemical drug additives with different functions, can achieve multiple effects of preventing and treating oral diseases, such as preventing dental caries, fresh breath, anti-inflammatory and bactericidal, Desensitization, whitening teeth and other effects. Biological enzyme stabilizer, when added to the paste, can ensure the stable existence of various biological enzymes, such as copper pyrithione and its salts, Tween, Span, peptone, gelatin. Biological enzyme activators, which can improve the activity of biological enzymes, such as manganese chloride, calcium chloride, magnesium chloride, taurine, glycine, and aspartic acid.

The preparation method of the present invention is as follows:

Adopt color bar toothpaste technology: when preparing enzyme-containing paste, add one or more of the same type of classified biological enzymes to the same color bar, and select other toothpaste ingredients and ingredients according to the characteristics of biological enzymes Biological enzyme stabilizer to ensure the stable existence of various biological enzymes; when preparing the conditioning paste, chemical drug additives and biological enzyme activators are added. One color of conditioning paste and one or more colors of enzyme-containing paste are then canned together to form a colored bar toothpaste. When the color bar toothpaste is used, the bio-enzyme activator can increase the activity of the bio-enzyme, and can improve the efficacy of the bio-enzyme to prevent and treat dental diseases.

The preparation method of the multifunctional color bar enzyme toothpaste mainly includes the following steps:

The first step, prepare and adjust the paste, the specific preparation process is as follows: first, according to the above weight percentage, mix the sorbitol in the humectant with polyethylene glycol, water, saccharin, chemical drug additives (monofluorophosphoric acid) easily soluble in water Sodium, potassium nitrate, sodium phytate, sodium copper chlorophyllin, sodium chloride, etc.), sodium dihydrogen phosphate, pigments, etc.; The mixture of thickening agent; Add the chemical drug additive (sodium fluoride, trisodium phosphate, sodium pyrophosphate, potassium pyrophosphate, urea, sodium phytate, strontium chloride, Yujiechun, Zinc citrate, potassium citrate, calcium glycerophosphate, etc.) and biological enzyme activator, friction agent, surfactant, titanium dioxide, essence, menthol, etc., stir evenly and degas to make a paste.

The second step, preparing enzyme-containing pastes of different colors, the preparation process of each enzyme-containing paste is the same, and the specific preparation process is as follows: first, mix the sorbitol in the humectant with polyethylene glycol, water , saccharin, sodium dihydrogen phosphate, pigment, etc. and stir evenly; then, add the mixture of glycerin or propylene glycol and diethylene glycol, thickener, and biological enzyme in the humectant according to the above weight percentage; finally add biological enzyme according to the above weight percentage to stabilize Agent, friction agent, surfactant, titanium dioxide, essence, menthol, etc., stir evenly and degas to make a paste.

In the third step, filling, the prepared adjusting paste and the enzyme-containing paste are filled into the toothpaste tube together, and a multi-functional color bar enzyme toothpaste is formed.

Below in conjunction with specific embodiment, the multi-functional color bar enzyme toothpaste of the present invention is described in further detail:

Example 1: The multi-functional color strip plus enzyme toothpaste is composed of pastes of three colors: blue paste, yellow paste, and colorless paste. Its respective composition and weight percent content are as follows:

Blue paste (containing enzyme paste):

Sorbitol 68%, glycerin 5%, polyoxyethylene (10) sodium lauryl ether phosphate 0.5%, 2-undecyl-N-carboxymethyl hydroxyethyl imidazoline betaine 0.5%, saccharin 0.1%, Sodium carboxymethyl cellulose 0.3%, seaweed gel 0.85%, mint flavor 0.8%, silicon dioxide 15%, lysozyme 0.05%, catalase 0.05%, Span 0.5%, sodium dihydrogen phosphate 0.25%, bright Blue 1# (1% aqueous solution) 0.05%, water 8.05%.

Yellow paste (containing enzyme paste):

Sorbitol 68%, Glycerin 3%, Sodium Lauryl Sarcosinate 2.5%, Saccharin 0.3%, Seaweed Gum 1%, Peppermint Flavor 0.8%, Silicon Dioxide 15%, Glucanase 0.3%, Glucose Oxidation Enzyme 0.05%, copper pyrithione 0.5%, sodium dihydrogen phosphate 0.5%, quinoline yellow (1% aqueous solution) 0.05%, water 8%.

Colorless paste (conditioning paste):

Sorbitol 68%, Glycerin 5%, Sodium Lauryl Sulfate 1.7%, Saccharin 0.1%, Carmellose Sodium 1%, Peppermint Flavor 0.8%, Silicon Dioxide 15%, Magnesium Chloride 0.1%, Strontium Chloride 0.3 %, water 8%.

The preparation method of the multifunctional color bar enzyme toothpaste of this embodiment is as described above. The pastes of the three colors can be packed together to form a yellow, white and blue transparent color striped toothpaste. Among them, in the blue paste, lysozyme and catalase can exist stably in the range of pH 6 to 7, and the polyoxyethylene (10) sodium lauryl ether phosphate and 2- The two surfactants, undecyl-N-carboxymethyl hydroxyethyl imidazoline betaine, have little effect on their stability, while Span has a stabilizing effect on them, so these two biological enzymes can work in the blue The paste exists stably; in the yellow paste, the pH value of dextranase and glucose oxidase is both 3.0-7.0, and pyrithione has a stabilizing effect on it, so these two biological enzymes can exist stably In yellow paste; in colorless paste, because sodium lauryl sulfate has a great influence on biological enzyme activity, it is added to this component, and it is also to improve the foaming property of toothpaste; while magnesium chloride is Their activator, when the paste of three colors is mixed, can increase the activity of biological enzymes. This toothpaste (a mixture of three colors) combines four biological enzymes and strontium chloride, so it has multiple functions such as anti-inflammatory, desensitizing, whitening, removing plaque, preventing and treating alveolar suppuration.

Example 2: The multi-functional color bar plus enzyme toothpaste consists of pastes of three colors: yellow paste, white paste, and green paste. Its respective composition and weight percent are as follows:

Yellow paste (containing enzyme paste):

Sorbitol 30%, Propylene Glycol 3%, Polyethylene Glycol 6%, Sodium Lauryl Sarcosinate 3%, Saccharin 0.2%, Sodium Carboxymethylcellulose 0.85%, Seaweed Gel 0.7%, Spearmint 0.8% , silicon dioxide 18%, protease 0.1%, pineapple enzyme 1%, peptone 0.1%, sodium dihydrogen phosphate 0.25%, titanium dioxide 0.5%, tartrazine (1% aqueous solution) 0.5%, water 35%.

White paste (containing enzyme paste):

Sorbitol 17%, Glycerin 3%, Sodium Lauryl Sarcosinate 6%, Saccharin 0.2%, Xanthan Gum 1.7%, Spearmint 1.2%, Calcium Hydrogen Phosphate 50%, Superoxide Dismutase 0.005%, Fat Enzyme 0.005%, Tween 2%, sodium dihydrogen phosphate 0.1%, water 18.79%.

Green paste (conditioning paste):

Sorbitol 17%, Glycerin 3%, Sodium Lauryl Sulfate 2.5%, Saccharin 0.25%, Xanthan Gum 1.7%, Spearmint 1.2%, Calcium Hydrogen Phosphate 50%, Taurine 0.1%, Sodium Dihydrogen Phosphate 0.5%, sodium copper chlorophyllin 0.03%, water 23.72%.

The preparation method of the multifunctional color bar enzyme toothpaste of this embodiment is as described above. The pastes of the three colors can be packed together to form a yellow, white and green color strip toothpaste. Among them, due to the stable pH value of protease and pineapple enzyme in the yellow paste is 6.0-7.0, sodium lauryl sarcosinate has little influence on them, while peptone has a stabilizing effect on it, so these two biological enzymes can Stable existence; due to the stable existence of superoxide dismutase and lipase in the white paste, the pH value is 6.0-10.5, sodium lauryl sarcosinate basically has no effect on these two enzymes, while Tween has a stabilizing effect on them , so these two biological enzymes can exist stably; in the green paste, because sodium lauryl sulfate has a greater impact on the activity of biological enzymes, it is added to this component, and it is also to improve the foaming of the toothpaste Sex; taurine is the activator of these enzymes, when the three colors of paste are used in combination, the activity of biological enzymes can be improved. This toothpaste (a mixture of three colors) combines four kinds of biological enzymes and sodium copper chlorophyllin, so it can decompose the residue in the mouth, deodorize, freshen the breath, and treat gingivitis, periodontitis, oral ulcers, etc. effect.

Example 3: The toothpaste with multi-functional color bar plus enzyme is composed of pastes of two colors: white paste and red paste. Its respective composition and weight percent content are as follows:

White paste (containing enzyme paste):

24% sorbitol, 10% diethylene glycol, 5% glycerin, 2.5% imidazoline amphoteric surfactant, 0.1% saccharin, 1.05% sodium carboxymethyl cellulose, 0.3% xanthan gum, 0.1% menthol, peppermint Spearmint essence 0.8%, silicon dioxide 25%, titanium dioxide 1%, amylase 1.5%, papain 0.5%, span 4%, sodium dihydrogen phosphate 0.5%, water 23.65%.

Red paste (regulating paste):

Sorbitol 20%, Glycerin 5%, Polyethylene Glycol 6%, Sodium Lauryl Sulfate 2.5%, Saccharin 0.3%, Sodium Carboxymethyl Cellulose 1.05%, Carrageenan 0.6%, Menthol 0.1%, Menthol Blue essence 1.05%, silicon dioxide 20%, titanium dioxide 1%, calcium chloride 1%, sodium dihydrogen phosphate 0.14%, sodium monofluorophosphate 0.76%, potassium nitrate 5%, red 28# (1% aqueous solution) 0.5 %, water 35%.

The preparation method of the multifunctional color bar enzyme toothpaste of this embodiment is as described above. The pastes of the two colors can be packed together to form a red and white color bar toothpaste. Among them, in the white paste, due to the stable existence of amylase and papain, the pH value is 3.0 to 7.0, and the imidazoline series amphoteric surfactant has little influence on the stability of these two enzymes, while Span has a stabilizing effect on it, so These two biological enzymes can exist stably; in the red paste, because sodium lauryl sulfate has a greater impact on the activity of biological enzymes, it is added to this component, and it is also to improve the foaming properties of the toothpaste. Calcium chloride is the activator of these enzymes. When the pastes of two colors are used together, the enzyme activity of biological enzymes can be improved. This toothpaste (a mixture of two color pastes) combines two biological enzymes, sodium monofluorophosphate, and potassium nitrate, so it has multiple functions such as desensitization, decomposing food residues in the mouth, preventing dental caries, and whitening teeth.

Claims (7)

1. multifunctional enzyme-supplemented colorful toothpaste, it is characterized in that: this toothpaste is made up of a kind of adjusting mastic of color and the enzyme mastic that contains of multiple color, contain chemicals additive and enzyme activator in the described adjusting mastic, contain enzyme and enzyme stabilizing agent described containing in the enzyme mastic, the component of described adjusting mastic and weight percent content are:

Wetting agent 20～73%

Abrasivus 15～50%

Thickening agent 1～1.7%

Surfactant 1.7～2.5%

Essence 0.8～1.2%

Water 8～35%

Glucide 0.1～0.3%

Pigment 0～0.5%

Polyethylene Glycol 0～6%

Chemicals additive 0.03～5%

Mentholum 0～0.1%

Sodium dihydrogen phosphate 0～0.5%

Titanium dioxide 0～1%

Enzyme activator 0.1～1%

Described every kind of component and weight percent content that contains the enzyme mastic is:

Wetting agent 20～73%

Abrasivus 15～50%

Thickening agent 1～1.7%

Surfactant 1～6%

Essence 0.8～1.2%

Water 8～35%

Glucide 0.1～0.3%

Pigment 0～0.5%

Polyethylene Glycol 0～6%

Enzyme 0.01～2%

Mentholum 0～0.1%

Sodium dihydrogen phosphate 0.1～0.5%

Titanium dioxide 0～1%

Enzyme stabilizing agent 0.1～4%

Described enzyme is glucanase, lysozyme, protease, glucose oxidase, amylase, superoxide dismutase, catalase, lipase, carase or bromelain; In amylase, glucose oxidase, glucanase, the carase one or more are added in a kind of color mastic; In lysozyme, protease, catalase, the bromelain one or more are added in the mastic of another kind of color; In superoxide dismutase, the lipase one or both are added in the mastic of other color; Described chemicals additive is one or more in sodium monofluorophosphate, sodium fluoride, tertiary sodium phosphate, tetrasodium pyrophosphate, potassium pyrophosphate, potassium nitrate, carbamide, sodium phytate, strontium chloride, pure as jade pure, sodium copper chlorophllin, sodium chloride, zinc citrate, potassium citrate, the calcium glycerophosphate.

2. according to the described multifunctional enzyme-supplemented colorful toothpaste of claim 1, it is characterized in that: described enzyme stabilizing agent is one or more in pyridone sulfur copper and salt thereof, tween, span, peptone, the gelatin; Described enzyme activator is one or more in manganese chloride, calcium chloride, magnesium chloride, taurine, glycine, the aspartic acid.

3. according to the described multifunctional enzyme-supplemented colorful toothpaste of claim 1, it is characterized in that: described wetting agent is one or more in sorbitol, glycerol, propylene glycol, the diethylene glycol.

4. according to the described multifunctional enzyme-supplemented colorful toothpaste of claim 1, it is characterized in that: described surfactant is that sodium lauryl sulphate, sarcosyl, imidazoline are one or more in both sexes interfacial agent, polyoxyethanyl ether phosphoric acid and salt thereof, two polyoxy vinyl alkyl ether phosphoric acids and salt thereof, the polyoxyethanyl ether tripolyphosphate.

5. according to the described multifunctional enzyme-supplemented colorful toothpaste of claim 1, it is characterized in that: described abrasivus is one or more in calcium carbonate, silicon dioxide, aluminium hydroxide, the calcium hydrogen phosphate.

6. according to the described multifunctional enzyme-supplemented colorful toothpaste of claim 1, it is characterized in that: described thickening agent is one or more in sodium carboxymethyl cellulose, carrageenan, HEC, HANSHENGJIAO, alginate jelly, card ripple, the aluminium-magnesium silicate.

7. the preparation method of multifunctional enzyme-supplemented colorful toothpaste according to claim 1 is characterized in that this method comprises the steps:

1) mastic is regulated in preparation: first with the sorbitol in the wetting agent according to the percentage by weight of described adjusting mastic, chemicals additive soluble in water and raw material mix homogeneously soluble in water in water and the component, add glycerol, propylene glycol or diethylene glycol and mixtures of thickening agents in the wetting agent then, add chemicals additive not soluble in water at last, the enzyme activator, abrasivus, surfactant and other raw material stirring not soluble in water be the also degassing evenly, makes a kind of mastic of color;

2) the preparation different colours contain the enzyme mastic: the pH scope with the enzyme stable existence is divided into following three classes with described enzyme:

A. amylase, glucose oxidase, glucanase and carase,

B. lysozyme, protease, catalase and bromelain,

C. superoxide dismutase and lipase;

Contain the enzyme mastic with what above-mentioned three class enzyme were made different colours respectively, each preparation technology who contains the enzyme mastic is identical, concrete preparation technology is as follows: according to the described percentage by weight that contains the enzyme mastic earlier with the sorbitol in the wetting agent, water and raw material mix homogeneously soluble in water add glycerol, propylene glycol or diethylene glycol in the wetting agent and the mixture of thickening agent and enzyme then; Add enzyme stabilizing agent, abrasivus, surfactant and other raw material not soluble in water at last, stir and outgas, make and contain the enzyme mastic;

3) fill: the adjusting mastic that will prepare and contain the enzyme mastic and be filled to together in the Flexible tube for toothpaste, promptly make multifunctional enzyme-supplemented colorful toothpaste.