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CN1850020A - Anti-allergic oral-cavity article containing solutable aluminium salt, potassium salt and stronitium salt additive composition and preparing method therefor - Google Patents

Anti-allergic oral-cavity article containing solutable aluminium salt, potassium salt and stronitium salt additive composition and preparing method therefor Download PDF

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Publication number
CN1850020A
CN1850020A CN 200610054100 CN200610054100A CN1850020A CN 1850020 A CN1850020 A CN 1850020A CN 200610054100 CN200610054100 CN 200610054100 CN 200610054100 A CN200610054100 A CN 200610054100A CN 1850020 A CN1850020 A CN 1850020A
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salt
aluminum
strontium
potassium
oral
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韩泰军
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DENGKANG MOUTH CARE ARTICLE Co Ltd CHONGQING
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DENGKANG MOUTH CARE ARTICLE Co Ltd CHONGQING
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Abstract

The present invention relates to an antiallergic oral agent containing soluble aluminium salt, potassium salt and strontium salt additive composite. It is characterized by that the described aluminium salt is soluble inorganic aluminium compound and organic aluminium compound, and the weight percentage of said soluble aluminium salt, potassium salt and strontium salt additive composite in said antiallergic oral agent is 0.1-10%. It has obvious antiallergic action, at the same time in oral cavity it can produce the resistance to oral diseases.

Description

A kind ofly contain aluminum soluble salt and potassium salt, strontium salt adds anti-allergic oral-cavity article of compositions and preparation method thereof
Technical field
The present invention relates to a kind of antianaphylactic oral cavity component, concrete is contains aluminum soluble salt and potassium salt, the combination of strontium salt, and this component can strengthen the ability of oral cavity to oral disease when effectively preventing and alleviating hemodia.
Technical background
Dental hypersensitiveness is because decayed tooth, interlock, the wearing and tearing of tooth, or reason such as gingival atrophy causes.Hemodia is meant that the enamel (being also referred to as enamel) when tooth weares and teares gradually, expose dentin, because when all external irritants of variations in temperature, chemical, mechanical, electrolyte etc. act directly on dentin layer, can bring extremely uncomfortable instantaneous pain (bringing out property pain), for example, when having eaten such as the high food of sugar content, tart flavour fruit or Chilled Drinking Water, pain perception in an instant such as grind one's teeth in sleep.Tooth pain can produce ill effect to aspects such as daily dietetic life, oral hygiene nursing.Both at home and abroad normal employing of present existing antiallergic component is that one or both salts are as the desensitizing dental preparation, as a kind of strontium salt or a kind of potassium salt, or a kind of fluoride.These desensitizations are after preparations make oral-cavity article in certain proportion, and as toothpaste etc., the patient continues to use in a period of time dentin hypersensitiveness's symptom just to be eased or improves.But because in the practical application, the focus complexity of dental hypersensitivity, so these desensitizing dental preparations may poor effect.Adopt aluminum soluble salt and potassium salt, strontium salt to make up in certain proportion among the present invention and made the desensitizing dental preparation, in the said preparation, potassium salt, strontium salt have different from desensitizing dental mechanism, simultaneously because composite the use has constringent aluminum soluble salt, the antiallergic ability of said preparation is strengthened, and can produce antiallergic effectiveness rapidly.
The mechanism of strontium salt desensitization is: if contain the strontium ion of trace in the dentine, can strengthen Dentinal desensitization ability.Enamel and dentin all can absorb strontium: the calcium carbonate effect in strontium and the dentine generates insoluble salt strontium carbonate SrCO 3, hydroxyl saamite Ca is produced in while and Dentinal hydroxyapatite effect 3(PO 4) 2Sr (OH) 2, on the essence surface of the dentine of wearing and tearing or exposure and be penetrated into the inner insoluble salt crystal that forms, block and cover canaliculi dentales, slow down the conduction of stimulation, thereby improved the ability of tooth antiallergic.Strontium can also the mineralising dentine character with and the ability of combine with Organic substance in the dentin (as oxygen and hemoglobin) permeability of hard tooth tissue is significantly reduced, and play antiacid desensitization.
The mechanism of potassium salt desensitization is: the potassium ion of free state is penetrated in the dental nerve tip, owing to changed the current potential of the cell membrane of neurocyte, the ability of dental nerve conducted signal is weakened, and pain perception is alleviated.
Aluminum salt is the salt with astriction, when aluminum soluble salt cooperation strontium salt, when the potassium salt compositions is applied to the oral cavity, promote inaccessible or the effect that canaliculi dentales is narrowed down, thereby strengthen its antianaphylactic effect, simultaneously when dentin hypersensitiveness takes place, use aluminum soluble salt and cooperate strontium salt, potassium salt compositions, can restrain oral soft tissue immediately, alleviate the tooth pain sensation rapidly.
The dual antiallergic toothpaste that Chinese invention patent CN01528260A contains potassium salt and strontium salt disclose a kind of toothpaste that contains potassium salt and two kinds of antianaphylaxis components of strontium salt with and preparation method thereof.
See with regard to present retrieval situation, yet there are no document and propose to adopt and to contain the relevant report that aluminum soluble salt and potassium salt, strontium salt add the preparation of compositions anti-allergic oral-cavity article.
Summary of the invention
Because strontium salt such as strontium chloride have the effect of sealing canaliculi dentales, mineralising dentine, thereby stop the effect of aching.And potassium salt such as potassium nitrate can weaken the activity of the dental pulp nerve conduction pain sensation.Aluminum soluble salt has the salt of astriction, when aluminum soluble salt cooperates strontium salt, when the potassium salt compositions is applied to the oral cavity, promotes inaccessible or the effect that canaliculi dentales is narrowed down, thereby strengthen its antianaphylactic effect.
Therefore, produce synergism, make the antiallergic effect of potassium salt, strontium salt more remarkable in the antiallergic effect of the astriction of aluminum soluble salt and single potassium salt or single strontium salt or potassium salt, strontium salt; And,, alleviate the symptom that tooth is ached rapidly because aluminum soluble salt also helps to tighten gingiva to the convergence of oral soft tissue.
Aluminum soluble salt of the present invention comprises that solubility do not have machine aluminium compound and organo-aluminum compound, and no machine aluminium compound comprises aluminum nitrate, aluminum sulfate, aluminum chloride, aluminium fluoride; Organo-aluminum compound comprises single ALUMINUM CARBOXYLIC such as aluctyl., aluminum citrate, glycol acid aluminum, dicarboxylic acids aluminum such as malonic acid aluminum, 1,3-propanedicarboxylic acid aluminum, malic acid aluminum, tartaric acid aluminum, the normal salt of tricarboxylic acids aluminum such as phytic acid aluminum and the special-shaped salt of alkali aluminum, first-selected aluctyl..
The purpose of this invention is to provide and a kind ofly contain aluminum soluble salt and potassium salt, strontium salt adds the anti-allergic oral-cavity article of compositions, it can prevent efficiently and effectively and alleviate the hemodia symptom.Another object of the present invention provides the described method that aluminum soluble salt and potassium salt, strontium salt add the antiallergic toothpaste of compositions that contains of producing.
The technical solution used in the present invention is such, promptly a kind ofly contains aluminum soluble salt and potassium salt, strontium salt adds the anti-allergic oral-cavity article of compositions, and it is characterized in that: described aluminum soluble salt is that solubility does not have machine aluminium compound and organo-aluminum compound; Describedly contain aluminum soluble salt and potassium salt, strontium salt to add compositions shared percentage by weight in the anti-allergic oral-cavity article constituent be 0.1～10%.
Described aluminum soluble salt and potassium salt, the strontium salt of containing adds compositions and comprises that aluminum soluble salt and potassium salt combination, aluminum soluble salt and the combination of strontium salt or aluminum soluble salt and potassium salt, strontium salt make up, and wherein the percentage by weight that accounts in the interpolation compositions of aluminum soluble salt is 5～50%.
Technique scheme applies on the toothpaste, in the toothpaste component, comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water, it is characterized in that: contain in the toothpaste component and account for the anti-allergic oral-cavity component that whole toothpaste component percentage by weight is 0.1～10% combination, optimal ratio is 1%～5%;
The lotion of toothpaste manufacture method of above-mentioned prescription is: adds wetting agent, adds binding agent again and stir homogenizing fast, add small powders such as sweeting agent, potassium salt and strontium salt successively, add the good aluminum soluble salt of dissolving again, and foaming agent and antiseptic, and evenly stir; Evacuation adds abrasivus then, stirs homogenizing, adds essence at last, stirs homogenizing, and the degassing, Paste Preparation are finished.Toothpaste is considered the most suitable oral-cavity article of technical solution of the present invention, but the present invention has more than to be limited to and be added in a kind of oral-cavity article of toothpaste, and other oral-cavity articles such as collutory, dentifrice, tooth gel, chewing gum are suitable for too.
The specific embodiment
Described aluminum soluble salt is an aluctyl., it accounts for percentage by weight and is preferably 10～50% in aluminum soluble salt and potassium salt combination, in the combination of aluminum soluble salt and strontium salt, account for percentage by weight and be preferably 10～50%, in aluminum soluble salt and potassium salt, strontium salt make up, account for percentage by weight and be preferably 10～50%.
The first-selected potassium nitrate of described potassium salt, it accounts for percentage by weight and is preferably 50～90% in aluminum soluble salt and potassium salt combination, account for percentage by weight and be preferably 10～50% in aluminum soluble salt and potassium salt, strontium salt make up.
The first-selected strontium chloride of described strontium salt, it accounts for percentage by weight and is preferably 50～90% in aluminum soluble salt and potassium salt combination, and strontium salt accounts for percentage by weight and is preferably 10～50% in aluminum soluble salt and potassium salt, strontium salt make up.
Described antiallergic component applies on the toothpaste, and it accounts for percentage by weight and is preferably 1%～5% in whole paste components.
Described antiallergic component applies on the toothpaste, and wetting agent can use single or its mixture such as glycerol, sorbitol, propylene glycol, and formula proportion can be 10%～70%, and preferred 20%～40%;
Described antiallergic component applies on the toothpaste, and binding agent can use single or its mixture such as sodium hydroxyethyl cellulose, carboxymethyl cellulose, carrageenan, yellow first glue, and formula proportion can be 0.1%～10%, and preferred 0.5%～2%;
Described antiallergic component applies on the toothpaste, and abrasivus can use calcium carbonate, hydrated SiO 2, calcium hydrogen phosphate, aluminium hydroxide etc., and formula proportion can be 10%～60%, and preferred 20%～50%.
Described antiallergic component applies on the toothpaste; surfactant comprises: single or its mixture such as anion, cation, both sexes and non-ionic surface active agent; for example sodium lauryl sulfate, N-acyl group sodium sarcosinate, hydramine, poloxamer; preferred nonionic surfactants such as poloxamer; amount ranges is can be 0.1%～10%, preferred 0.1%～3%.
Described antiallergic component applies on the toothpaste, and sweeting agent comprises: saccharin sodium, stevioside etc.Amount ranges 0.1%～2%, preferred 0.1%～0.5%.
Described antiallergic component applies on the toothpaste, and antiseptic comprises: parabenzoic acid ester and sodium benzoate etc.Amount ranges 0.1%～2%, preferred 0.1%～1%.
Described antiallergic component applies on the toothpaste, and essence can use Herba Menthae, Oleum Menthae Rotundifoliae, Mentha piperita, anethole etc.Amount ranges 0.1%～5%, preferred 0.1%～1.5%.
Hydromining pure water, consumption are 10%～50%, preferred 15%～30%.
For verifying the antiallergic effect of aluminum soluble salt of the present invention and potassium salt, strontium salt pref, it is added in this toothpaste implements, but do not limit the present invention.
Table 1 Example formulations table
Figure A20061005410000081
Glycerol 1.00～10.00 1.00～10.00 1.00～10.00 1.00～10.00
Sorbitol 20.00～40.00 20.00～40.00 20.00～40.00 20.00～40.00
Friction-type silicon dioxide 5.00～15.00 5.00～15.00 5.00～15.00 5.00～15.00
Thickening type silicon dioxide 5.00～10.00 5.00～10.00 5.00～10.00 5.00～10.00
CMC 0.50～1.50 0.50～1.50 0.50～1.50 0.50～1.50
Sodium lauryl sulfate 1.00～2.50 1.00～2.50 1.00～2.50 1.00～2.50
Saccharin sodium 0.10～0.50 0.10～0.50 0.10～0.50 0.10～0.50
Titanium dioxide 0.05～0.30 0.05～0.30 0.05～0.30 0.05～0.30
Essence 0.50～1.50 0.50～1.50 0.50～1.50 0.50～1.50
Potassium nitrate -- -- 0.50～5.00 0.50～4.00
Strontium chloride -- -- 0.50～5.00 0.50～4.00
Aluctyl. -- 0.5-10.0 -- 0.5～2.0
Water Surplus Surplus Surplus Surplus
Production technology is: in main frame, adds sorbitol, glycerol earlier, adds adhesive C MC again and stir homogenizing fast, add small powders such as saccharin sodium, aluctyl., potassium nitrate and strontium chloride successively, and foaming agent and sodium benzoate, and evenly stir; Evacuation adds abrasive material silicon dioxide then, stirs homogenizing, adds essence at last, stirs homogenizing, outgases, makes mastic.
Four groups of toothpaste shown in the his-and-hers watches 1 carry out the antiallergic clinical trial, and 120 people that suffer from sensitivity of tooth are divided into equal four groups at random.They respectively with the toothpaste of I, II, III, IV group, continue three months according to the daily habits of brushing teeth (brushing teeth every day twice).The results are shown in Table 2.
Table 2 result of the test
Figure A20061005410000101
Conclusion: from table 2, we as can be seen: the effect of II group, III group and IV group are organized blank sample contrast with I and are had significant difference, illustrate that II group, III group and IV group all have antiallergic effect.Among the embodiment, the II group, the III group, in mastic, occupy identical weight percentage ratio with the antianaphylaxis components of IV group, but the antiallergic effect of IV group significantly is better than III group and II group effect, this illustrates potassium salt, strontium salt, has collaborative antianaphylactic effect after aluminum soluble salt is composite, synergism significantly is better than using separately aluminum soluble salt group or potassium salt, the anti-hemodia effect of strontium salt group, effectively slow down and prevented patient's responsive phenomenon, clinical trial is also observed and has been used the potassium salt that adds aluminum soluble salt simultaneously, the potassium salt of experimental group contrast interpolation aluminum soluble salt of strontium salt toothpaste, the experimental group of strontium salt toothpaste, patient's oral sensation is to tangible astriction, when patient's hemodia takes place, this effect is reduction of patient pain phenomenon rapidly, alleviates the patient suffering.

Claims (8)

1, a kind ofly contain aluminum soluble salt and potassium salt, strontium salt adds the anti-allergic oral-cavity article of compositions, it is characterized in that: described aluminum soluble salt is that solubility does not have machine aluminium compound and organo-aluminum compound; Describedly contain aluminum soluble salt and potassium salt, strontium salt to add compositions shared percentage by weight in the anti-allergic oral-cavity article constituent be 0.1-10%.
2, as claimed in claim 1ly contain aluminum soluble salt and potassium salt, strontium salt adds the oral-cavity article of the anti-allergic oral-cavity component of compositions, it is characterized in that: described aluminum soluble salt and potassium salt, the strontium salt of containing adds compositions and comprises that aluminum soluble salt and potassium salt combination, aluminum soluble salt and the combination of strontium salt or aluminum soluble salt and potassium salt, strontium salt make up, and wherein the percentage by weight that accounts in the interpolation compositions of aluminum soluble salt is 5～50%.
3, as claimed in claim 2ly contain aluminum soluble salt and potassium salt, strontium salt adds the oral-cavity article of the anti-allergic oral-cavity component of compositions, it is characterized in that: 5～50% of the percentage by weight that the aluminum soluble salt in described aluminum soluble salt and the combination of strontium salt or aluminum soluble salt and potassium salt, the combination of strontium salt accounts in component, potassium salt accounts for 10～95% in component, strontium salt accounts for 10～95% in component.
4, as claimed in claim 1 or 2ly contain aluminum soluble salt and potassium salt, strontium salt adds the oral-cavity article of the anti-allergic oral-cavity component of compositions, it is characterized in that: described solubility does not have machine aluminium compound and comprises aluminum nitrate, aluminum sulfate, aluminum chloride, aluminium fluoride, organo-aluminum compound comprises aluctyl., aluminum citrate, glycol acid aluminum, malonic acid aluminum, 1,3-propanedicarboxylic acid aluminum, malic acid aluminum, tartaric acid aluminum, at least a in the special-shaped salt of the normal salt of phytic acid aluminum or alkali aluminum.
5, as claimed in claim 1 or 2ly contain aluminum soluble salt and potassium salt, strontium salt adds the oral-cavity article of the anti-allergic oral-cavity component of compositions, it is characterized in that: the first-selected potassium nitrate of described potassium salt, but be not limited only to potassium nitrate.
6, as claimed in claim 1 or 2ly contain aluminum soluble salt and potassium salt, strontium salt adds the oral-cavity article of the anti-allergic oral-cavity component of compositions, it is characterized in that: the first-selected strontium chloride of described strontium salt, but be not limited only to strontium chloride.
7, a kind ofly contain aluminum soluble salt and potassium salt, strontium salt adds the antiallergic toothpaste of compositions, in the toothpaste component, comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water, it is characterized in that: aluminum soluble salt and potassium salt in the toothpaste component, strontium salt add compositions to account for whole toothpaste component percentage by weight are 0.1～10%, and optimal ratio is 1%～5%.
8, a kind of preparation is as the technology of antiallergic toothpaste as described in the claim 7, it is characterized in that: add wetting agent, add binding agent again and stir homogenizing fast, add small powders such as sweeting agent, potassium salt and strontium salt successively, add the good aluminum soluble salt of dissolving again, foaming agent and antiseptic, and evenly stir; Evacuation adds abrasivus then, stirs homogenizing, adds essence at last, stirs homogenizing, and the degassing, Paste Preparation are finished.
CN 200610054100 2006-02-27 2006-02-27 Anti-allergic oral-cavity article containing solutable aluminium salt, potassium salt and stronitium salt additive composition and preparing method therefor Pending CN1850020A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105055223A (en) * 2015-08-10 2015-11-18 庄立 Traditional Chinese medicine toothpaste capable of stopping bleeding and desensitizing
TWI551299B (en) * 2013-03-15 2016-10-01 美國棕欖公司 Oral care compositions
CN107028799A (en) * 2017-02-21 2017-08-11 广州薇美姿实业有限公司 A kind of oral cavity baste of antiallergic whitening
CN109431834A (en) * 2018-12-20 2019-03-08 扬州倍加洁日化有限公司 Add oral cavity composition and its application of bioactivity glass and strontium chloride

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI551299B (en) * 2013-03-15 2016-10-01 美國棕欖公司 Oral care compositions
US9717662B2 (en) 2013-03-15 2017-08-01 Colgate-Palmolive Company Oral care compositions
CN105055223A (en) * 2015-08-10 2015-11-18 庄立 Traditional Chinese medicine toothpaste capable of stopping bleeding and desensitizing
CN107028799A (en) * 2017-02-21 2017-08-11 广州薇美姿实业有限公司 A kind of oral cavity baste of antiallergic whitening
CN107028799B (en) * 2017-02-21 2020-05-12 广州薇美姿实业有限公司 Anti-allergy whitening oral cavity smearing liquid
CN109431834A (en) * 2018-12-20 2019-03-08 扬州倍加洁日化有限公司 Add oral cavity composition and its application of bioactivity glass and strontium chloride

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