CN1766111A - Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport - Google Patents

Abstract

Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from corynebacterium glutamicum based on genetic engineering of HA genes in this organism.

Description

The proteinic Corynebacterium glutamicum gene of coding involved in homestasis and adaptation

The application is to be on June 23rd, 2000 applying date, and application number is 00811818.3, and denomination of invention is divided an application for the application for a patent for invention of " the proteinic Corynebacterium glutamicum gene of coding involved in homestasis and adaptation ".

Related application

The application requires in the right of priority of the U.S. Provisional Patent Application sequence number (SN) 60/141031 of application on June 25th, 1999.The application also requires the right of priority of following patent application: the German patent application of on July 8th, 1999 application numbers 19931636.8, the German patent application of on July 9th, 1999 application numbers 19932125.6, the German patent application of on July 9th, 1999 application numbers 19932126.4, the German patent application of on July 9th, 1999 application numbers 19932127.2, the German patent application of on July 9th, 1999 application numbers 19932128.0, the German patent application of on July 9th, 1999 application numbers 19932129.9, the German patent application of on July 9th, 1999 application numbers 19932226.0, the German patent application of on July 14th, 1999 application numbers 19932920.6, the German patent application of on July 14th, 1999 application numbers 19932922.2, the German patent application of on July 14th, 1999 application numbers 19932924.9, the German patent application of on July 14th, 1999 application numbers 19932928.1, the German patent application of on July 14th, 1999 application numbers 19932930.3, the German patent application of on July 14th, 1999 application numbers 19932933.8, the German patent application of on July 14th, 1999 application numbers 19932935.4, the German patent application of on July 14th, 1999 application numbers 19932973.7, the German patent application of on July 14th, 1999 application numbers 19933002.6, the German patent application of on July 14th, 1999 application numbers 19933003.4, the German patent application of on July 14th, 1999 application numbers 19933005.0, the German patent application of on July 14th, 1999 application numbers 19933006.9, the German patent application of on August 31st, 1999 application numbers 19941378.9, the German patent application of on August 31st, 1999 application numbers 19941379.7, the German patent application of on August 31st, 1999 application numbers 19941390.8, the German patent application of the German patent application of on August 31st, 1999 application number application on September 3rd, 19941391.6 and 1999 numbers 19942088.2.The full content of all above-mentioned applications all is attached to herein by reference.

Background of invention

Some product of the metabolic process of natural generation and by product have practicality in diversified industry in cell, and described industry comprises foodstuffs industry, fodder industry, cosmetic industry and pharmacy industry.These molecules are referred to as " fine chemicals ", comprise organic acid, generate proteinic (proteinogenic) and the proteinic amino acid of non-generation, Nucleotide and nucleosides, lipid and lipid acid, dibasic alcohol, carbohydrate, aromatic substance, VITAMIN and cofactor and enzyme.Their production is to carry out in order to the large scale culturing of producing and secrete the bacterium of one or more a large amount of desired molecules by exploitation the most easily.A kind of useful especially biology that is used for this purpose is Corynebacterium glutamicum (Corynebacterium glutamicum), and this is a kind of gram-positive non-pathogenic bacteria.By the selection of bacterial strain, a series of required compound saltants of many generations have been developed.Yet, be a time-consuming and difficult process in the selection of improved bacterial strain aspect the specific molecular production.

Brief summary of the invention

The invention provides the novel bacteria nucleic acid molecule that serves many purposes.These purposes comprise the typing of fine chemicals is produced in evaluation, Corynebacterium glutamicum or the Related Bacteria of the microorganism that can be used for producing fine chemicals adjusting, Corynebacterium glutamicum or Related Bacteria or evaluation, as the reference point of Corynebacterium glutamicum gene group mapping and as the mark that transforms.These novel nucleic acids molecule encodings are called (HA) proteic protein of stable state and adaptation (homeostasis and adaptation) herein.

Corynebacterium glutamicum is a kind of Gram-positive aerophil, is generally used in the industry with the miscellaneous fine chemicals of scale operation the oxidation that also is used for carbohydrate degraded (for example being used for oil overflows) and is used for terpenoid.Therefore, can be used for identifying can be in order to for example to produce the microorganism of fine chemicals by fermenting process for HA nucleic acid molecule of the present invention.The modification of the adjusting of HA expression of nucleic acid of the present invention or HA sequence of nucleic acid molecules of the present invention can derive from the production (for example deriving from the yield or the output of one or more fine chemicals of excellent bacillus or tyrothricin bacterial classification with improvement) of one or more fine chemicals of microorganism in order to adjusting.

It is Corynebacterium glutamicum or its closely related bacterial classification that HA nucleic acid of the present invention also can be used for biological assay, or is used for identifying the existence of Corynebacterium glutamicum in the mixing microorganisms colony or its relevant bacterial classification.The invention provides the nucleotide sequence of multiple Corynebacterium glutamicum gene; By probe with leap Corynebacterium glutamicum gene district, the genomic dna of the extraction of the culture of peculiar microorganism of detection or mixing microorganisms colony under stringent condition, people can determine whether this biology exists.Though Corynebacterium glutamicum itself is a non-virulent, it with the mankind in pathogenic species for example corynebacterium diphtheriae (Corynebacterium diphtheriae) (pathogenic agent of diphtheria) is relevant; The detection of this class biology has great clinical meaning.

HA nucleic acid molecule of the present invention also can be as the reference point of Corynebacterium glutamicum gene group or associated biomolecule genomic mapping.Equally, these molecules or its varient or its part can be as the marks of genetically engineered rod bacillus or tyrothricin bacterial classification.

Can for example carry out the function that participates in keeping the Corynebacterium glutamicum homeostasis or participate in the ability of this microorganism adaptation varying environment condition by the HA albumen of novel nucleic acids molecule encoding of the present invention.The known cloning vector that obtains being used for Corynebacterium glutamicum is the U.S. Patent number 4 of Sinskey etc. for example, 649, cloning vector in 119 and be used for Corynebacterium glutamicum and relevant tyrothricin bacterial classification (for example brevibacterium (Brevibacterium lactofermentum)) Genetic Manipulative Technology (Yoshihama etc., J.Bacteriol.162:591-597 (1985); Katsumata etc., J.Bacteriol.159:306-311 (1984); With Santamaria etc., J.Gen.Microbiol.130:2237-2246 (1984)), therefore nucleic acid molecule of the present invention can be used for the genetically engineered of this biology, so that it becomes the better or more effective producer of one or more fine chemicals.This improved production of fine chemicals or productive rate may be because the direct effect of the operation of gene of the present invention causes, perhaps it may be that indirect effect by this generic operation causes.

There are many mechanism to make and change yield, output or the productive rate that HA albumen of the present invention can directly influence the proteic Corynebacterium glutamicum strain production fine chemicals that mixes this change.For example, undertaken engineered by enzyme to modification or degraded aromatic substance or aliphatic cpd, make these enzymes active or quantitatively increase or reduce, might regulate generation as one or more fine chemicals of the modification of these compounds or degraded product.Equally, participate in the biosynthesizing that the metabolic enzyme of described mineral compound can be this class fine chemicals such as amino acid, VITAMIN and nucleic acid key molecule (for example phosphorus, sulphur and nitrogen molecule) is provided.By changing the activity or the quantity of these enzymes in the Corynebacterium glutamicum, might increase the conversion (or use substitute mineral compound) of these mineral compound, make the speed that inorganic atoms is mixed in these fine chemicals improve thus.The Corynebacterium glutamicum enzyme that participates in the ubiquity cell processes is carried out genetically engineered, also can directly improve the generation of fine chemicals, because the many enzymes in these enzymes are directly modified fine chemicals (for example amino acid) or participated in the synthetic or excretory enzyme of fine chemicals.The adjusting of pair cell protease activity or quantity also may have direct influence to the generation of fine chemicals, the enzyme that fine chemicals or participation fine chemicals produce or decompose because a lot of proteolytic enzyme can be degraded.

In addition, participating in aromatics/aliphatic cpd modification or degraded, general biocatalysis, mineral compound metabolism or proteoclastic above-mentioned enzyme itself all is fine chemicals, needs its activity in various external industrial application.By changing the copy number of the gene of one or more these enzymes in the Corynebacterium glutamicum, might increase these proteinic quantity that cell produces, improve extensive Corynebacterium glutamicum or Related Bacteria culture thus and produce these proteinic potential yield or productive rates.

The proteic change of HA of the present invention also may remote effect be mixed this class through changing yield, output and/or the productive rate of proteic Corynebacterium glutamicum strain production fine chemicals.For example, by cell walls makes up or those activity of proteins and/or the quantity of rearrangement are regulated to participating in, might modify the structure of cell walls itself, the mechanical stress that causes cell to withstand better to exist between the large scale fermentation incubation period and other stress.In addition, a large amount of cell walls of the extensive growth needs of Corynebacterium glutamicum produces.The activity or the quantity of pair cell wall biosynthetic enzyme or degrading enzyme are regulated, can be so that the biosynthetic speed of cell walls be quicker, this so can increase the cell quantity of producing required fine chemicals thus so that this microbial growth speed improves in the culture.

By modifying HA enzyme of the present invention, also can the remote effect Corynebacterium glutamicum produce yield, output or the productive rate of one or more fine chemicals.For example, many general enzymes have great effect to general (global) cell processes (for example regulate process) in the Corynebacterium glutamicum, this so that to fine chemicals metabolism has great effect.Equally, the enzyme of proteolytic enzyme, modification or toxicity aromatics of degrading possible or aliphatic cpd and the metabolic enzyme of promotion mineral compound all can be used to improve the viability of Corynebacterium glutamicum.The protein that these proteolytic enzyme help optionally to remove malfolding or regulate through mistake, for example those protein that under the envrionment conditions of the Metus compulsiva that may run between large scale fermentation jar incubation period, exist.By changing these protein, the viability that might further strengthen this activity and improve Corynebacterium glutamicum in the culture.Aromatics/aliphatic series is modified or degrade proteins not only can be used for these refuse compounds (these compounds may run into as the refuse of impurity in the substratum or cell self) detoxifcation, and allows cell the suitableeest carbon source in culture to have in limited time can to utilize alternative carbon source.By increasing its quantity and/or activity, the survival that can improve glutamic acid rod bacilli-cell in the culture.Inorganic metabolizable protein of the present invention is cell supply all proteins and the synthetic required inorganic molecule of Nucleotide (this is one of them), and therefore the total viability for cell is vital.Increase the quantity of producing the viable cell of one or more required fine chemicals in the large scale culturing thing, should cause improving simultaneously yield, output and/or productive rate that fine chemicals described in the described culture is produced.

The invention provides coding this paper and be called the proteic novel nucleic acids molecule of HA, described HA albumen can for example be carried out and participate in keeping the Corynebacterium glutamicum homeostasis or participating in the function that this microorganism adapts to the ability of varying environment condition.The proteic nucleic acid molecule of coding HA is referred to herein as the HA nucleic acid molecule.In a preferred embodiment, described HA albumen participate in Corynebacterium glutamicum cell walls biosynthesizing or rearrangement, mineral compound metabolism, aromatics or aliphatic cpd modification or degraded or have a kind of Corynebacterium glutamicum enzymic activity or proteolytic activity.The example of this proteinoid comprises those albumen by genes encoding described in the table 1.

Therefore, one aspect of the present invention relates to isolated nucleic acid molecule (for example cDNA, DNA or RNA), described isolated nucleic acid molecule comprises the nucleotide sequence of coding HA albumen or its biologically-active moiety, also relates to being suitable as detecting or the primer of amplification HA coding nucleic acid (for example DNA or mRNA) or the nucleic acid fragment of hybridization probe.In particularly preferred embodiments, described isolated nucleic acid molecule comprises odd number SEQ ID NO in the sequence table (for example SEQ IDNO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7 ...) described in coding region or its complementary sequence of one of one of nucleotide sequence or these nucleotide sequences.In other particularly preferred embodiment, isolated nucleic acid molecule of the present invention comprises such nucleotide sequence or its part, described nucleotide sequence and a kind of sequence table odd number SEQ ID NO (for example SEQID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7 ...) described in nucleotide sequence hybridization or have at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90% even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher homology.In other preferred embodiment, described isolated nucleic acid molecule code sequence tabulation even number SEQ ID NO (for example SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQID NO:8 ...) described in one of aminoacid sequence.The preferred HA albumen of the present invention also preferably has at least a HA activity as herein described.

In another embodiment, described isolated nucleic acid molecule encode a kind of protein or its part, wherein said albumen or its part comprise to be enough to and aminoacid sequence of the present invention (sequence that for example has even number SEQ ID NO in the sequence table) homologous aminoacid sequence, for example be enough to and amino acid sequence homologous of the present invention, make described protein or its part keep the HA activity.Preferably, protein or its part by described nucleic acid molecule encoding keeps the ability that participates in keeping the Corynebacterium glutamicum homeostasis or carry out the function that participates in this microorganism adaptation varying environment condition.In one embodiment, by the homology of the protein of described nucleic acid molecule encoding and aminoacid sequence of the present invention (for example being selected from complete aminoacid sequence) with even number SEQ ID NO in the sequence table be at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or higher.In another preferred embodiment, described protein be with complete amino acid sequence of the present invention (by corresponding odd number SEQ ID NO in the sequence table (for example SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQID NO:7 ...) shown in open reading-frame (ORF) coding) homologous total length Corynebacterium glutamicum protein basically.

In another preferred embodiment, described isolated nucleic acid molecule derives from Corynebacterium glutamicum, and a kind of protein (for example HA fusion rotein) that comprises a biologically active structure territory of encoding, described biologically active structure territory and a kind of aminoacid sequence of the present invention (for example sequence of a kind of even number SEQ ID NO in the sequence table) have at least about 50% or higher homology, and can participate in reparation or the reorganization of the DNA in the Corynebacterium glutamicum, the swivel base of genetic material, genetic expression (promptly transcribing or translation process), protein folding or protein secreting, or having one or more activity described in the table 1, described isolated nucleic acid molecule also comprises the heterologous nucleic acid sequence of coding heterologous polypeptide or regulatory region.

In another embodiment, described isolated nucleic acid molecule is to 15 Nucleotide of the youthful and the elderly, and under stringent condition with the making nucleic acid molecular hybridization that comprises nucleotide sequence of the present invention (for example sequence of odd number SEQ IDNO in the sequence table).Preferred described isolated nucleic acid molecule is corresponding to naturally occurring nucleic acid molecule.The naturally occurring HOMEOSTASIS ADAPTATION PROTEIN of more preferably described isolating nucleic acid encoding or its biologically-active moiety.

Another aspect of the present invention relates to the carrier that contains nucleic acid molecule of the present invention, and for example recombinant expression vector relates to the host cell that imports this class carrier.In one embodiment, a kind of like this host cell is used for producing HA albumen by cultivate described host cell in suitable medium.From described substratum or described host cell, isolate described HA albumen then.

The microorganism that relates in one aspect to the hereditary change that has wherein imported HA gene or change HA gene more of the present invention.In one embodiment, by importing nucleic acid molecule of the present invention, changed the genome of described microorganism as genetically modified encoding wild type or mutant HA sequence.In another embodiment, the endogenous HA gene in the described microbial genome is by being changed for example functional fracture with the HA dna homolog reorganization that changes.In another embodiment, HA gene endogenous or that introduced is changed by one or more point mutation, disappearance or inversion in the microorganism, but still encoding function HA albumen.In an embodiment again, one or more regulatory regions of HA gene in the microorganism (for example promotor, repressor or inductor) are changed (for example by disappearance, brachymemma, inversion or point mutation), make that described HA expression of gene is adjusted.A preferred embodiment, described microorganism belongs to Corynebacterium or brevibacterium sp, preferred especially Corynebacterium glutamicum.In a preferred embodiment, described microorganism also is used to produce required compound, for example amino acid, especially preferably Methionin.

On the other hand, the invention provides corynebacterium diphtheriae existence or its active method in a kind of evaluation curee body.This method comprises detection intravital one or more nucleotide sequences of the present invention of curee or aminoacid sequence (for example sequence described in the sequence table SEQ ID NO 1-440), detects existence or its activity of corynebacterium diphtheriae in described curee's body thus.

Another aspect of the present invention relates to isolated SMP proteins or its part, biological example active part.In a preferred embodiment, described separation HA albumen or its part can participate in keeping the Corynebacterium glutamicum homeostasis and maybe can carry out the function that this microorganism of participation adapts to the varying environment condition.In another preferred embodiment, described isolated SMP proteins or its part and aminoacid sequence of the present invention (for example sequence of even number SEQ ID NO in the sequence table) be homology enough, makes described protein or its part keep and participates in keeping the Corynebacterium glutamicum homeostasis or carry out the ability of this microorganism to the function of varying environment condition adaptation that participate in.

The present invention also provides HA proteic separation preparation.In preferred embodiments, described HA albumen comprises aminoacid sequence of the present invention (for example sequence of even number SEQ ID NO in the sequence table).In another preferred embodiment, the present invention relates to and complete amino acid sequence of the present invention (for example sequence of even number SEQ ID NO in the sequence table) (by the described open reading-frame (ORF) of corresponding odd number SEQID NO among sequence table A coding) the isolating full length protein of homologous basically.In an embodiment again, the homology of described protein and complete amino acid sequence of the present invention (for example sequence of even number SEQID NO in the sequence table) is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or higher.In other embodiments, described isolated SMP proteins comprise with the homology of a kind of aminoacid sequence of the present invention (for example sequence of even number SEQ ID NO in the sequence table) at least about 50% or higher aminoacid sequence, and can participate in keeping the Corynebacterium glutamicum homeostasis or carry out participating in the function that this microorganism adapts to the varying environment condition, or have one or more activity described in the table 1.

Perhaps, described isolated SMP proteins can comprise a kind of so nucleotide sequence coded aminoacid sequence, the described nucleotide sequence hybridization of a kind of even number SEQ ID NO in described nucleotide sequence and the sequence table, hybridize under stringent condition for example, or with sequence table in the homology of nucleotide sequence shown in a kind of odd number SEQID NO at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or higher.The also preferred proteic preferred form of HA also has one or more HA biological activitys described herein.

Described HA polypeptide or its biologically-active moiety can be connected effectively with a kind of non-HA polypeptide, form fusion rotein.In preferred embodiments, this fusion rotein has and is different from the independent proteic activity of described HA.In other preferred embodiment, this fusion rotein participates in keeping the Corynebacterium glutamicum homeostasis or carries out and participates in the function that this microorganism adapts to the varying environment condition.In particularly preferred embodiments, this fusion rotein is incorporated in the host cell, and the required compound of regulating described cell produces.

On the other hand, the invention provides the method that is used to screen the molecule of regulating the HA protein-active, described molecule or by interacting with HA albumen itself or as proteic substrate of described HA or binding partners, perhaps, regulate the HA protein-active by regulating transcribing or translating of HA nucleic acid molecule of the present invention.

Another aspect of the present invention relates to the method that is used to produce fine chemicals.This method comprises cultivates the cell that contains the carrier that instructs HA nucleic acid molecule expression of the present invention, makes and can produce fine chemicals.In a preferred embodiment, this method comprises that also acquisition contains the step of the cell of this carrier, wherein with the carrier transfectional cell that instructs the HA expression of nucleic acid.In another preferred embodiment, this method also comprises the step that reclaims described fine chemicals from culture.In an especially preferred embodiment, described cell derives from Corynebacterium or brevibacterium sp, or is selected from those bacterial strains described in the table 3.

Another aspect of the present invention relates to the method that is used to regulate by the microorganisms producing molecule.These class methods comprise makes described cell contact with the factor of regulating HA protein-active or HA expression of nucleic acid, makes the cell related activity be changed for the described activity when lacking the described factor.In a preferred embodiment, regulate described cell and participate in the modification of metabolism, aromatics or aliphatic cpd of Corynebacterium glutamicum cell walls biosynthesizing or rearrangement, mineral compound or one or more processes of degraded or enzymic activity or proteolytic activity.The factor of regulating the HA protein-active can be the factor that stimulates HA protein-active or HA expression of nucleic acid.The example of the factor of stimulation HA protein-active or HA expression of nucleic acid comprises small molecules, active HA albumen and has been imported into the proteic nucleic acid of coding HA of described cell.The example of the factor that suppresses the HA activity or express comprises small molecules and antisense HA nucleic acid molecule.

Another aspect of the present invention relates to the method for the required compound yield of regulating cell, and described method comprises in wild-type or the mutant HA gene transfered cell, perhaps is retained on the independent plasmid or is incorporated in the genome of host cell.If be incorporated in the genome, then this integration can be at random, or it can take place by homologous recombination, makes described natural gene be replaced by the copy that is imported, and causes producing described required compound from cell to be regulated.In a preferred embodiment, described yield increases.In another preferred embodiment, described chemical is a kind of fine chemicals.In an especially preferred embodiment, described fine chemicals is a seed amino acid.In especially preferred embodiment, described amino acid is L-Methionin.

Detailed Description Of The Invention

The invention provides HA nucleic acid molecule and HA protein molecular, described molecule participate in Corynebacterium glutamicum cell walls biosynthesizing or rearrangement, mineral compound metabolism, aromatics or aliphatic cpd modification or degraded or have a kind of Corynebacterium glutamicum enzymic activity or proteolytic activity.

Molecule of the present invention can be used for or directly regulate for example fine chemicals production of Corynebacterium glutamicum of microorganism (for example wherein participating in the yield that proteinic overexpression that fine chemicals (for example a kind of enzyme) produces or its active optimization produce for the fine chemicals of modified Corynebacterium glutamicum, output and/or productive rate have a direct impact), maybe can have remote effect, in any case the yield that this all causes required compound to be produced, the raising of output and/or productive rate (is for example wherein modified or the activity of protein degradation or the adjusting of copy number Corynebacterium glutamicum aromatics or aliphatic series, cause the raising of Corynebacterium glutamicum cell survival, this so that make the increase of output in the large scale culturing environment).Below further specify all respects of the present invention.

I. fine chemicals

Term " fine chemicals " is well known in the art, comprises the molecule that has multiple application by biogenic in various industry (such as but not limited to pharmacy industry, agricultural and cosmetic industry).This compounds comprises organic acid, for example tartrate, methylene-succinic acid and diaminopimelic acid; Generate the proteinic amino acid of proteinic and non-generation; Purine and pyrimidine bases, nucleosides and Nucleotide (as being described in for example Kuninaka, A. (1996) Nucleotide and related compound are stated from Biotechnology, the 6th volume, the 561-612 page or leaf, Rehm etc. write, VCH:Weinheim and the reference that wherein contains); Lipid, saturated and unsaturated fatty acids (for example arachidonic acid); Dibasic alcohol (for example propylene glycol and butyleneglycol); Carbohydrate (for example hyaluronic acid and trehalose); Aromatic substance (for example aromatic amine, Vanillin and indigo); VITAMIN and cofactor (as are described in Ullmann ' s Encyclopedia of Industrial Chemistry, A27 volume, " Vitamins ", 443-613 page or leaf (1996) VCH:Weinheim and reference wherein; And Ong, A.S., Niki, E. and Packer, L (1995) " Nutrition; Lipids, Health, and Disease " Proceedings of the UNESCO/Confederation of Scientific and TechnologicalAssociations in Malaysia, and the Society for Free Radical Research-Asia, hold AOCS Press, (1995) at Malaysian Penang in 1-3 day in September, 1994); Enzyme; Polyketide (Cane etc. (1998) Science 282:63-68); Be described in Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation is among the ISBN:0818805086 and all other chemical of reference wherein.Some metabolism and application in these fine chemicals below is described in further detail.

A. amino acid metabolism and application

Amino acid comprises the basic structural unit of all proteins, is that all biological normal cell functions are requisite therefore.Term " amino acid " is well known in the art.Generating proteinic amino acid has 20 kinds, and as proteinic structural unit, they connect by peptide bond in protein; But not normal discovery in protein of the amino acid (known hundreds of described amino acid) that albumen generates (referring to Ulmann ' s Encyclopedia of Industrial Chemistry, A2 volume, 57-97 page or leaf VCH:Weinheim (1985)).Amino acid can have D-or L-optical configuration, though L-amino acid generally is the unique type of finding in the naturally occurring protein.20 kinds of biosynthesizing and degradation pathway that generate in the proteinic amino acid every kind have characterized (referring to for example Stryer, L.Biochemistry, the 3rd edition, 578-590 page or leaf (1988)) well in prokaryotic cell prokaryocyte and eukaryotic cell." essential " amino acid (Histidine, Isoleucine, leucine, Methionin, methionine(Met), phenylalanine, Threonine, tryptophane and Xie Ansuan) is name so, be because their biosynthesizing complexity, generally be to need in the nutrition, described " essential " amino acid is converted into all the other 11 kinds of " nonessential " amino acid (L-Ala, arginine, l-asparagine, aspartic acid, halfcystine, L-glutamic acid, glutamine, glycine, proline(Pro), Serine and tyrosine) by simple biosynthetic pathway easily.Higher animal keeps some amino acid in synthetic these amino acid really, but indispensable amino acid must supply from diet, so that carry out normal protein synthesis.

Except the function of these amino acid in the protein biosynthesizing, these amino acid self still are interesting chemical, have been found that wherein many amino acid have various application in foodstuffs industry, fodder industry, chemical industry, cosmetic industry, agricultural and pharmacy industry.Methionin is not only the important amino acid of human nutrition, and is the important amino acid of monogastric animal (for example poultry and pig) nutrition.L-glutamic acid is the most frequently used to be made odor control additive (monosodium glutamate MSG), and is extensive use of in foodstuffs industry, and aspartic acid, phenylalanine, glycine and halfcystine also are like this.Glycine, L-methionine(Met) and tryptophane all are used for pharmacy industry.Glutamine, Xie Ansuan, leucine, Isoleucine, Histidine, arginine, proline(Pro), Serine and L-Ala are valuable on pharmacy industry and cosmetic industry.Threonine, tryptophane and D/L-methionine(Met) are the fodder additivess of using always.(Leuchtenberger, W. (1996) amino acid-technology production and application is stated from (writing) Biotechnology such as Rehm, the 6th volume, the 14a chapter, the 466-502 page or leaf, VCH:Weinheim).In addition, have been found that these amino acid can be used as the precursor of synthesizing amino acid and protein synthesis, for example N-acetylcystein, S-carboxymethyl-L-halfcystine, (S)-5-hydroxytryptophan and be described in Ulmann ' s Encyclopedia of IndustrialChemistry, the A2 volume, the 57-97 page or leaf, VCH:Weinheim, other amino acid of 1985.

Characterize (the synthetic and summary of regulating of relevant bacterium amino acid bio well can producing intravital these the natural amino acid whose biosynthesizing of these natural amino acid whose biologies (for example bacterium), referring to Umbarger, H.E. (1978) Ann.Rev.Biochem.47:533-606).By the reductive amidation of the intermediate α-Tong Wuersuan in the tricarboxylic acid cycle, synthetic L-glutamic acid.Produce glutamine, proline(Pro) and arginine respectively by L-glutamic acid subsequently.The biosynthesizing of Serine is one three step process, with 3-phoshoglyceric acid (intermediate in the glycolysis-) beginning, behind oxidation, transamination and hydrolysing step, produces this seed amino acid.Halfcystine and glycine are all produced by Serine, and the former produces by homocysteine and Serine condensation, and the latter produces by in the catalytic reaction side chain beta carbon being transferred to tetrahydrofolic acid (THFA) by serine transhydroxymethylase at one.Phenylalanine and tyrosine in the synthetic back of prephenic acid in the 9 step biosynthetic pathways that only latter two steps is different, synthetic by glycolysis-and pentose-phosphate pathway precursor erythrose-4-phosphate and phosphoenolpyruvic acid.Tryptophane is also produced by these two kinds of starting molecules, but its synthetic be one 11 step approach.Tyrosine also can be synthetic by phenylalanine in the catalytic reaction by Phenylalanine hydroxylase at one.L-Ala, Xie Ansuan and leucine all are the biosynthetic products of glycolysis-end product-pyruvic acid.Aspartic acid is generated by the intermediate oxaloacetic acid of tricarboxylic acid cycle.L-asparagine, methionine(Met), Threonine and Methionin produce by the conversion of aspartic acid respectively.Isoleucine is generated by Threonine.9 step approach of a complexity cause producing Histidine by a kind of activation sugar-ribose 5-phosphate-1-tetra-sodium.

Amino acid in the excessive protein synthesis demand of cell can not be stored, but be degraded, (relevant summary is referring to Stryer for the main metabolic pathway of cell provides intermediate, L.Biochemistry, the 3rd edition, the 21st chapter, " amino acid degradation and ornithine cycle ", 495-516 page or leaf (1988)).Though cell can be converted into undesired amino acid in useful metabolism intermediate, with regard to the necessary enzyme of energy, precursor molecule and synthesizing amino acid, amino acid production is expensive.Therefore, amino acid bio is synthetic, and regulated by feedback inhibition be N/R, in feedback inhibition, the existence of specific amino acids play a part to slow down or stop fully himself producing (summary of the Feedback mechanism in the relevant amino acid biosynthetic pathway, referring to Stryer, L.Biochemistry, the 3rd edition, the 24th chapter, " biosynthesizing of amino acid and protoheme ", 575-600 page or leaf (1988)).Therefore, the output of any specific amino acids is subjected to the amino acid quantitative limitation that exists in the cell.

B. the metabolism of VITAMIN, cofactor and nutritional drugs and application

VITAMIN, cofactor and nutritional drugs comprise other component that higher animal has been lost synthesis capability and therefore must take in, and for example bacterium is synthetic although they are easily by other biology.These molecules or itself are biologically active substances, or can be as the precursor as the biologically active substance of the intermediate of electron carrier or multiple pathways metabolism.These compounds are except having nutritive value, and the essential industry that also has as tinting material, antioxidant and catalyzer or other processing aid is worth.(about the general introduction of structure, activity and the industrial application of these compounds, referring to for example Ullman ' s Encyclopedia of Industrial Chemistry, " Vitamins ", A27 volume, 443-613 page or leaf, VCH:Weinheim, 1996).Term " VITAMIN " is well known in the art, comprise biological normal function required but biological self can not the synthetic nutrition.Vitamins can comprise cofactor and nutritional drugs compound.Term " cofactor " comprises the active required non-albumen compound of generation normal enzyme.This compounds can be organic compound or mineral compound; Cofactor molecule of the present invention is organic molecule preferably.Term " nutritional drugs " is included in the dietary supplement that has health advantages among plant and animal, the particularly mankind.The example of this quasi-molecule is VITAMIN, antioxidant and some lipid (for example polyunsaturated fatty acid).

Characterized in a large number these molecules for example biosynthesizing in the bacterium of the biology that can produce it (Ullman ' s Encyclopedia of Industrial Chemistry, " Vitamins ", A27 volume, 443-613 page or leaf, VCH:Weinheim, 1996; Michal, G. (1999) Biochemical Pathways:An Atlas of Biochemistry and Molecular Biology, John Wiley ﹠amp; Sons; Ong, A.S., Niki, E and Packer, L. (1995) " Nutrition, Lipids, Health; and Disease " Proceedrugs of the UNESCO/Confederationof Scientific and Technological Associations in Malaysia, and the Societyfor Free Radical Research-Asia holds AOCS Press:Champaign in 1-3 day in September, 1994 at Malaysian Penang, IL X, 374S).

By with pyrimidine and the chemical coupling of thiazole part, produce VitB1 (vitamins B ₁).Riboflavin (vitamins B ₂) synthetic by guanosine-5 '-triphosphoric acid (GTP) and ribose-5 '-phosphoric acid.Riboflavin and then be used for synthetic vitamin B2 phosphate (FMN) and flavin adenine dinucleotide (FAD).Be referred to as " vitamins B ₆" compound family (for example pyridoxine hydrochloride of pyridoxol, Pyridoxylamine, pyridoxal-5 '-phosphoric acid and commercial use) all be derivative with common structure unit 5-hydroxyl-6-picoline.Pantothenic acid ((R)-(+)-N-(2,4-dihydroxyl-3,3-dimethyl-1-oxo butyl)-Beta-alanine) can or by chemosynthesis or pass through fermentative production.Last step in the pantothenic acid biosynthesizing is made up of Beta-alanine and pantoic acid condensation that ATP drives.The enzyme of being responsible for the biosynthesizing step of the condensation that is converted into pantoic acid, Beta-alanine and is converted into pantothenic acid is known.The pantothenic acid of metabolic activity form is coenzyme A, and its biosynthesizing is carried out with 5 enzymatic steps.Pantothenic acid, pyridoxal-5 '-phosphoric acid, halfcystine and ATP are the precursors of coenzyme A.These enzymes are the generation of catalysis pantothenic acid not only, and the generation of catalysis (R)-pantoic acid, (R)-pantolacton, (R)-panthenol (provitamin B5), pantetheine (and derivative) and coenzyme A.

Study the vitamin H biosynthesizing that begins by precursor molecule pimeloyl coenzyme A in the microorganism in great detail, and identified related several genes.It is synthetic to have been found that many corresponding proteins matter also participate in iron bunch, and is the member of nifS proteinoid.Thioctic Acid is derived from sad, and as the coenzyme in the energy metabolism, it becomes the part of pyruvate dehydrogenase complex and ketoglurate dehydrogenase complex body in energy metabolism.The folic acid class is the material of a class folic acid derivatives, and folic acid is again derived from L-L-glutamic acid, para-amino benzoic acid and 6-methylpterin.At length studied the biosynthesizing of folic acid and derivative thereof in certain micro-organisms, described biosynthesizing originates in metabolism intermediate guanosine-5 '-triphosphoric acid (GTP), L-L-glutamic acid and para-amino benzoic acid.

Corrinoid (for example cobalami, particularly vitamins B ₁₂) and porphyrin belong to the chemical substance that a category feature is the tetrapyrrole ring system.Vitamins B ₁₂Biosynthesizing enough complicated so that do not identified fully as yet, but known many related enzymes and substrate now.Nicotinic acid and niacinamide are pyridine derivates, are also referred to as " nicotinic acid ".Nicotinic acid is the important coenzyme NAD (Reduced nicotinamide-adenine dinucleotide) and the precursor of NADP (Triphosphopyridine nucleotide, reduced) and reduction form thereof.

The scale operation of these compounds mainly relies on acellular chemosynthesis always, although some in these chemical also produced for example riboflavin, vitamins B by extensive microorganism culturing ₆, pantothenic acid and vitamin H.Vitamins B only ₁₂Because its synthetic complicacy is passed through fermentative production.In vitro method spends big content of starting materials and time, and ordinary expenditure is huge.

C. the metabolism of purine, pyrimidine, nucleosides and Nucleotide and application

Purine and pyrimidine metabolic gene and corresponding proteins matter thereof are the important treatment targets of tumor disease and virus infection.Term " purine " or " pyrimidine " comprise nitrogenous base, and they are components of nucleic acid, coenzyme and Nucleotide.Term " Nucleotide " comprises the basic structural unit of nucleic acid molecule, they by a nitrogenous base, (under the situation of RNA, described sugar is ribose to a pentose; Under the situation of DNA, described sugar is the D-ribodesose) and the phosphoric acid formation.Term " nucleosides " comprises the molecule that is used as nucleotide precursor but lacks the phosphoric acid part that Nucleotide had.By biosynthesizing that suppresses these molecules or the transfer that suppresses its formation nucleic acid molecule, might suppress the synthetic of RNA and DNA; Suppress this activity by mode, the ability that can suppress tumour cell division and duplicate with target cancer cell.In addition, have and do not form nucleic acid molecule but as energy storage (being AMP) or as the Nucleotide of coenzyme (being FAD and NAD).

Several publications have been described by influencing purine and/or pyrimidine metabolic, these chemical substances are used for these medical science indications (Christopherson for example, R.I. and Lyons, S.D. (1990) " as pyrimidine and from the beginning biosynthetic effective inhibitor of purine of chemotherapeutic ", Med.Res.Reviews 10:505-548).The research of the enzyme that participates in purine and pyrimidine metabolic is concentrated on always can be as exploitation (Smith, J.L., (1995) " enzyme during Nucleotide is synthetic ", the Curr.Opin.Struct.Biol.5:752-757 of the new drug of for example immunosuppressor or antiproliferative agents; (1995) Biochem Soc.Transact.23:877-902).Yet, purine and pyrimidine bases, nucleosides and Nucleotide have other purposes: as several fine chemicals (VitB1 for example, S-adenosine-methionine(Met), folic acid or riboflavin) biosynthetic intermediate, be used as the energy carrier (for example ATP or GTP) of cell and be used for chemical self, usually be used as flavine toughener (for example IMP or GMP) or be used for several drugs and use (referring to for example Kuninaka, A. (1996) Nucleotidesand Related Compounds in Biotechnology, the 6th volume, Rehm etc. write, VCH:Weinheim, the 561-612 page or leaf).In addition, the enzyme that participates in purine, pyrimidine, nucleosides or nucleotide metabolism is used for the target of the chemical of cover crop more and more as exploitation, and described chemical comprises mycocide, weedicide and sterilant.

(relevant summary is referring to for example Zalkin to have identified the metabolism of these compounds in bacterium, H. and Dixon, J.E. (1992) " from the beginning biosynthesizing of purine nucleotides ", be stated from: Progress in Nucleic Acid Research and Molecular Biology, the 42nd volume, Academic Press, the 259-287 page or leaf; And Michal, G. (1999) " Nucleotide and nucleosides " is stated from: Biochemical Pathways:An Atlas of Biochemistry and MolecularBiology, the 8th chapter, Wiley:New York).Purine metabolism is the theme of broad research always, and is absolutely necessary for the normal function of cell.Purine metabolism is impaired in higher animal can cause serious disease, for example gout.Purine nucleotides is begun to synthesize by ribose-5-phosphoric acid, series of steps by midbody compound inosine-5 '-phosphoric acid (IMP), cause the generation of guanosine-5 '-a phosphoric acid (GMP) or adenosine-5 '-a phosphoric acid (AMP), generate the triphosphoric acid form that is used as Nucleotide easily by GMP or AMP.These compounds are also as energy storage, because its many different Biochemical processes that are degraded in the cell provide energy.The pyrimidine biosynthesizing is undertaken by forming uridine-5 '-a phosphoric acid (UMP) by ribose-5-phosphoric acid.UMP so be converted into Cytidine-5 '-triphosphoric acid (CTP).The deoxidation form of all these Nucleotide produced in the reduction reaction in a step, was the bisphosphate ribodesose form of described Nucleotide from the bisphosphate ribose form reduction reaction of described Nucleotide.After phosphorylation, it is synthetic that these molecules can participate in DNA.

D. the metabolism of trehalose and application

Trehalose is by with α, and two glucose molecules that α-1,1-bonding connect are formed.Trehalose usually as sweeting agent, promptly is used for a kind of additive of desiccating food products or frozen product and beverage in foodstuffs industry.Yet it also has many application (referring to for example Nishimoto etc., (1998) U.S. Patent number 5,759,610 in pharmacy industry, cosmetic industry and biotechnological industries; Singer, M.A. and Lindquist, S. (1998) Trends Biotech.16:460-467; Paiva, C.L.A. and Panek, A.D. (1996) Btotech.Ann.Rev.2:293-314; And Shiosaka, M. (1997) J.Japan 172:97-102).Trehalose is used for producing from the enzyme of many microorganisms, and natural being released in the surrounding medium, can collect trehalose from described surrounding medium with methods known in the art.

II. the Corynebacterium glutamicum homeostasis keep and to the adaptation of environment

The metabolic process that cell carries out and other biological process are to envrionment conditions for example temperature, pressure, solute concentration and oxygen availability sensitivity.When mode disturbed when one or more these envrionment conditionss or that change was incompatible with these cell processes normal functions, cell must take action to keep the interior environment of born of the same parents, and no matter how unfavorable born of the same parents' external environment has, and this all will make them to survive.Gram positive bacterium cell for example Corynebacterium glutamicum cell has many mechanism can keep homeostasis, no matter born of the same parents' external environment have how unfavorable.The toxicity aromatics that these comprise cell walls, can degrade possible and the protein of aliphatic cpd, can the rapid damage malfolding or be subjected to wrong proteinic proteolysis mechanism of regulating and catalyzer that the intramicellar reaction that allows not take place usually takes place under the bacterial growth optimum condition.

Except only surviving in adverse environment, bacterial cell (for example Corynebacterium glutamicum cell) also can adapt to usually, makes them can utilize this class condition.For example, cell can adapt on the carbon source that not too is fit to and grows in lacking the environment of required carbon source.In addition, when the mineral compound of common utilization was unavailable, cell may can utilize less-than-ideal mineral compound.The Corynebacterium glutamicum cell has a large amount of genes, makes them can adapt to utilize their the common inorganic molecule and organic molecules that can not run under optimum growing condition, as nutrient and metabolic precursor thereof.Below further set forth all respects of the cell processes that participates in stable state and adaptation.

A. the modification of aromatic substance and aliphatic cpd and degraded

Various aromatic substance and aliphatic cpd in common contact nature circle of bacterial cell.Aromatic substance is the organic molecule with cyclic rings structure, and aliphatic cpd are to have open-chain structure but not organic molecule with ring structure.The by product (for example benzene or toluene) that this compounds can be used as industrial processes occurs, but also can be produced (for example alcohols) by certain micro-organisms.Many pair cells in these compounds are poisonous, aromatic substance particularly, and aromatic substance is highly reactive owing to the high energy ring structure has.Therefore, some bacterium has been developed the mechanism that them and can modify or degrade these compounds, makes that described compound pair cell is no longer poisonous.Cell may have and can make they or toxicity reduce aromatics or aliphatic cpd for example hydroxylation, isomerization or methylated enzyme, makes that perhaps modified form can be by standard cell lines refuse and degradation pathway processing.In addition, cell may have the enzyme of one or more these class potentially harmful substances of can specificity degrading, and protects cell thus.The principle of the modification of these types and degradation process and example have description in the bacterium in several publications, Sabm for example, H. (1999) " prokaryotic organism in the industrial production ", be stated from Lengeler, J.W. wait and write, Biologyof the Procaryotes, Thieme Verlag:Stuttgart; And Schlegel, H.G. (1992) Allgemeine Mikrobiologie, Thieme:Stuttgart).

Except will being harmful to aromatics or aliphatic cpd inactivation simply, many bacteriums can utilize these compounds to carry out continuous metabolism as carbon source when having evolved to such an extent that its preferred carbon source at cell can not be obtained.For example, known pseudomonas strain can utilize toluene, benzene and 1, and 10-two chlorodecanes are as carbon source (Chang, B.V. etc. (1997) Chemosphere 35 (12): 2807-2815; Wischnak, C. etc. (1998) Appl.Environ.Microbiol.64 (9): 3507-3511; Churchill, S.A. etc. (1999) Appl.Environ.Microbiol.65 (2): 549-552).The similar example that has from many other bacteria cultures known in the art.

Some bacterium is modified or the ability of degraded aromatics and aliphatic cpd has begun to obtain to utilize.Oil is a kind of mixture of chemical substance of complexity, and it comprises aliphatic molecule and aromatic substance.For example have the ability these toxic compounds to be degraded or modify the bacterium that becomes oil slick by using, might high-level efficiency and eliminate at low cost many environmental damages (referring to for example Smith, M.R. (1990) " bacterium is to the biological degradation of aromatic hydrocarbons " Biodegradation 1 (2-3): 191-206; And Suyama, T. etc. (1998) " bacterial isolates of degraded aliphatic polycarbonate ", FEMSMicrobiol.Lett.161 (2): 255-261).

B. the metabolism of mineral compound

Cell (for example bacterial cell) contains a large amount of differing moleculars, for example water, mineral ion and organic substance (for example protein, carbohydrate and other macromole).The typical cellular materials of great majority only are made of four types atom-carbon, oxygen, hydrogen and nitrogen.Though inorganic substance are represented the entocyte of less per-cent, the normal function of they and cell is equal to important.This quasi-molecule comprises phosphorus, sulphur, calcium, magnesium, iron, zinc, manganese, copper, molybdenum, tungsten and cobalt.For example the formation of Nucleotide (phosphorus) and amino acid (nitrogen and sulphur) is most important for important molecule for many in these compounds.Other ion in these mineral ions is used as the cofactor of enzymatic reaction or influences osmotic pressure.All these quasi-molecules must be absorbed from surrounding environment by bacterium.

For every kind of these mineral compound, it is desirable to bacterium and absorb the form that to utilize the most fast by the Standard Metabolism machine of cell.Yet bacterium may meet with the environment that these preferred forms are not easy to obtain.In order under these environment, to survive, for bacterium, importantly have extra active lower but form that obtain easily in these mineral compound metabolism can be converted in cellular metabolism can type of service biochemical mechanism.Bacterium has the gene that a large amount of codings are used for the enzyme of this purpose usually, and these genes are just expressed can not obtaining required inorganic kind of time-like.Therefore, metabolic these genes of various mineral compound can be used for adapting to another instrument of inferior suitable envrionment conditions as bacterium.

After carbon, of paramount importance element is a nitrogen in the cell.Typical bacterial cell contains the nitrogen of 12-15%.It is the component of many other important molecule in amino acid and Nucleotide and the cell.In addition, nitrogen can replace oxygen as the terminal electron acceptor in the energy metabolism.Good nitrogenous source comprises many organic compound and mineral compound, and for example ammonia or ammonium salt are (for example 、 Or ), nitrate, urea, amino acid or compound nitrogen source such as corn steep liquor, soyflour, soybean protein, yeast extract paste, meat extract etc.The nitrogen of ammonia is fixed by the effect of certain enzyme: glutamate dehydrogenase, glutamine synthase and glutamine-2-oxoglutaric acid transaminase.Amino nitrogen is transferred to another kind of organic molecule from an organic molecular species and is finished by transaminase, and transaminase is a class is transferred to an amino alpha-ketoacid from a-amino acid a enzyme.Nitrate can reduce by nitrate reductase, nitrite reductase and other oxydo-reductase, and being converted into it until it can be by cell easy dinitrogen or ammonia that utilizes in the Standard Metabolism approach.

Phosphorus finds with organic form and inorganic form in cell usually, and can by cell with or these forms in any absorption, although most of microbe preferential absorption inorganic phosphate.Organic phosphoric acid is converted into the utilizable form of cell, needs the effect of Phosphoric acid esterase (phytase for example, its hydrolysis of inositol six phosphoric acid produce phosphoric acid and inositol derivative).Phosphoric acid is the key component of nucleic acid in synthetic, also has vital role (for example in ATP, ADP and AMP synthetic) in the cellular energy metabolism.

Sulphur is that amino acid (for example methionine(Met) and halfcystine), VITAMIN (for example VitB1, vitamin H and Thioctic Acid) and iron-sulphur protein are synthetic required.Bacterium mainly obtains sulphur from inorganic sulfuric acid, although also utilize thiosulfuric acid, sulfurous acid and sulfide usually.Under the condition that these compounds are not easy to obtain; many bacterial expressions can make it utilize for example gene (Kertesz of 2-thionamic acid (taurine) of sulfoacid compound; M.A. (1993) " limit inductive protein by sulfuric acid in intestinal bacteria, pseudomonas putida (Pseudomonas putida) or the streptococcus aureus (Staphylococcus aureus) ", J.Bacteriol.175:1187-1190).

Other inorganic atoms, for example metal ion or calcium ion also are important for cell survival.Iron for example has vital role in redox reaction, and is the cofactor of iron-sulphur protein, reduced hematin and cytopigment.With iron absorb in the bacterial cell can by siderophore be used for finish, siderophore is to be transported to the sequestrant of cell interior in conjunction with the outer iron ion of born of the same parents and with them.About iron and the metabolic reference of other mineral compound, referring to: Lengeler etc. (1999) Biology of Prokaryotes, Thieme Verlag:Stuttgart; Neidhardt, F.C etc. write Escherichia coli and Salmonella, ASM Press:Washington, D.C.; Sonenshein, do A.L. etc. write (199?) Bacillus subtilis and Other Gram-PositiveBacteria, ASM Press:Washington, D.C.; Voet, D. and Voet, J.G. (1992) Biochemie, VCH:Weinheim; Brock, T.D. and Madigan, M.T. (1991) Biologyof Microorgansisms, the 6th edition, Prentice Hall:Englewood Cliffs, 267-269 page or leaf; Rhodes, P.M. and Stanbury, P.F.Applied Microbial Physiology-APractical Approach, Oxford Univ.Press:Oxford.

C. enzyme and proteolysis

For bacterium for example in the born of the same parents that optimize of Corynebacterium glutamicum condition be not the conditions that many biochemical reactions take place usually usually.Carry out for these are reflected under the physiological condition, cell utilizes enzyme.Enzyme is the albumen biological catalyst, is the molecule of orientation response on the space, or the specialization environment is provided, and makes the energy barrier of biochemical reaction reduce.The reaction that different enzyme catalysiss is different, every kind of enzyme can be the main body that transcriptional regulatory, translation are regulated or the translation back is regulated, and makes this reaction only take place in appropriate condition and specified time.Enzyme can cause degradation (for example proteolytic enzyme), synthetic (for example synthase) or modify (for example transferring enzyme or isomerase), and all these makes can produce essential compound in cell.This so cause keeping the automatic adjusting of cell.

Yet enzyme is the suitableeest for the activity under the most active physiological condition of bacterium, and this fact means when envrionment conditions is interfered, and probably also will disturb the activity of this enzyme.For example, the change of temperature may cause unusual folding protein, the change of pH also is so-protein folding depends primarily on amino acid whose electrostatic interaction and hydrophobic interaction in the polypeptide chain, so any change (may cause owing to the change of cellular pH) of each amino acid electric charge can have far-reaching influence for the correctly folding ability of protein in the polypeptide chain.The change of temperature changes the amount of peptide molecule institute tool kinetic energy effectively, and this influences polypeptide becomes correct ability folding, the energetics structural stability.Misfolded proteins matter may have two reasons by pair cell.The first, unusual folding protein may have same abnormal activity, or does not have activity at all.The second, misfolded proteins matter may lack and is subjected to the necessary conformation of other cell system normal regulating district, therefore may continue to have activity, but in a kind of uncontrolled mode activity be arranged.

Cell have a kind of mechanism can be before any infringement that pair cell takes place the rapid damage malfolding enzyme and regulate albumen: proteolysis.Protein for example those protein specific ground identifications of those protein of la/lon family and Clp family and degraded misfolded proteins matter (referring to for example Sherman, M.Y., Goldberg, A.L. (1999) EXS 77:57-78 and reference wherein and Porankiewicz J. (1999) Molec.Microbiol.32 (3): 449-58 and reference wherein; Neidhardt, F.C. etc. (1996) E.coli and Salmonella, ASM Press:Washington, D.C. and reference wherein; And Pritchard, G.G. and Coolbear, T. (1993) FEMS Microbiol.Rev.12 (1-3): 179-206 and reference wherein).These enzymes and malfolding or folding protein bound and it is degraded in ATP dependency mode.Therefore, proteolysis damages the important mechanisms of normal cell function when being used for preventing environment change as cell, it also is to make cell to survive in the deleterious conditions and environment owing to being subjected to wrong adjusting and/or unusual enzymic activity or adjusting activity under other situation.

Proteolysis also has critical function under the environmental optima condition in cell.In the eubolism process, proteolytic enzyme helps the hydrolysis of peptide bond, the katabolism of complicated molecule, so that essential degraded product to be provided, and helps protein modified.Excretory proteolytic enzyme in addition externally nutrient enter and in these compound decomposition metabolism, have vital role before the cell.In addition, protease activity itself can be used as regulatory function; Cell cycle progression in sporulation in the known Bacillus subtilus and the handle bacillus (Caulobacter spp.) is subjected to adjusting (Gottesman, S. (1999) Curr.Opin.Microbiol.2 (2): 142-147) of key protein hydrolysis incident in each these bacterial classification.Therefore, the proteolysis process all is important for the existence that the Asia accommodates cell under the environmental optima condition, and influences totally keeping of cell homeostasis.

D. the generation of cell walls and rearrangement

Though the biochemical machine of cell can easily adapt to different possible hostile environments, cell still needs to protect the general mechanism of their opposing environment.For many bacteriums, cell walls provides this protection, is also adhering to, is working aspect cell growth and division and required solute and the refuse transhipment.

In order to carry out its function, the intracellular concentration that cell needs metabolite and other molecule is the concentration of projecting medium basically.Because these metabolites can not leave cell basically owing to the existence of hydrophobic membrane,, make the inside concentration of solute and outside concentration mate so the tendency of this system makes water molecules enter cell from external agency.Water molecules can easily be crossed cytolemma, and this film can not be resisted caused expansion and pressure, and this may cause the infiltration cracking of cell.The rigidity of cell walls has improved the ability of these pressure of cell tolerance greatly, and another road barrier of the undesirable diffusion from cell to these metabolites and required solute is provided.Equally, cell walls is used for also preventing that undesired material from entering cell.

Cell walls also participates in many other cell processes, for example adheres to and cell growth and cell fission.Because cell walls centers on this fact of cell fully, so any interaction of cell and its ambient substance must be mediated by cell walls.Therefore, cell walls must participate in cell and any of other cell and required surface adheres to.In addition, if cell walls does not change simultaneously, then cell can not grow or divide.Since this protection that cell walls provided need growth, form take place and between nursery stage cell walls exist, so one of the committed step in the cell fission is that intracellular cell walls is synthetic, makes from the old cell division cell that makes new advances.Therefore, usually the biosynthesizing of cell walls is subjected to being connected adjusting (referring to for example Sonenshein with cell growth and cell fission, A.L. wait and write (1993) Bacillus subtilis and Other Gram-PositiveBacteria, ASM:Washington, D.C.).

The structure of cell walls is different between gram positive bacterium and gram negative bacterium.Yet, in these two types, the fundamental structural unit of cell walls is still similar: the overlapping grid of two kinds of polysaccharide-N-acetyl-glucosamines (NAG) and-acetylmuramic acid (NAM), these two kinds of polysaccharide are crosslinked by amino acid (the most normal is L-L-Ala, D-L-glutamic acid, diaminopimelic acid and D-L-Ala), are called " peptidoglycan ".Known participation cell walls synthetic process (referring to for example Michal, G. writes (1999) Biochemical Pathways:An Atlas ofBiochemistry and Molecular Biology, Wiley:New York).

In gram negative bacterium, the cell inner membrance is surrounded by individual layer peptidoglycan (about 10nm is thick), is called murein-folliculus.This peptidoglycan structure is very hard, its structures shape shape that should biology.The outside surface of murein-folliculus covers the adventitia that one deck contains porin and other membranin, phosphatide and lipopolysaccharides.In order to keep and the combining closely of adventitia, the cell walls of gram negative bacterium also has the lipid molecule of distribution, be used for its be anchored into around film on.

Gram positive bacterium for example in the Corynebacterium glutamicum, plasma membrane is coated with the multiwalled peptidoglycan, its thickness is that 20-80nm does not wait (referring to (1999) BiologyProkaryotes Thieme Verlag:Stuttgart such as for example Lengeler, 913-918 page or leaf, 875-899 page or leaf and 88-109 page or leaf and reference wherein).The cell walls of gram positive bacterium also contains teichoic acid, and this is a kind of by the glycerine of phosphate-based connection or the polymkeric substance of ribitol.Teichoic acid also can be connected with amino acid, and forms covalent linkage with teichoic acid.In cell walls, also may there be lipoteichoicacid and teichuronic acid.Structure of cell surface such as flagellum or folder film also will be anchored in this layer if any.

III. element of the present invention and method

The present invention is called the recruit's of HA nucleic acid molecule and HA protein molecular discovery to small part based on this paper, and described HA molecule participates in keeping the Corynebacterium glutamicum homeostasis or carries out and participates in the function that this microorganism adapts to the varying environment condition.In one embodiment, the HA molecule participate in Corynebacterium glutamicum cell walls biosynthesizing or rearrangement, mineral compound metabolism, aromatics or aliphatic cpd modification or degraded or have a kind of enzymic activity or proteolytic activity.In a preferred embodiment, that this biology is produced required fine chemicals is influential for the activity of the modification of metabolism, aromatics or the aliphatic cpd of HA molecule relevant Corynebacterium glutamicum cell walls biosynthesizing of the present invention or rearrangement, mineral compound or degraded or enzymic activity or proteolytic activity.In an especially preferred embodiment, HA molecule of the present invention is regulated on activity, the Corynebacterium glutamicum cell processes (for example modification of the metabolism of biosynthesizing of Corynebacterium glutamicum cell walls or rearrangement, mineral compound, aromatics or aliphatic cpd or degraded or enzymic activity or proteolytic activity) that makes described HA molecule participate in also is changed the yield, output and/or the productive rate that cause or regulate directly or indirectly Corynebacterium glutamicum to produce required fine chemicals on activity.

Term " HA albumen " or " HA polypeptide " comprise that participation is with Corynebacterium glutamicum stable state or the Corynebacterium glutamicum cell protein to the relevant various kinds of cell process of adverse environment condition adaptive faculty.For example, HA albumen can participate in the modification or the degraded of aromatics in the metabolism, Corynebacterium glutamicum of mineral compound in the biosynthesizing of Corynebacterium glutamicum cell walls or rearrangement, the Corynebacterium glutamicum or aliphatic cpd or have a kind of Corynebacterium glutamicum enzymic activity or proteolytic activity.

The proteic example of HA comprises those protein by HA gene described in the table 1 and odd number SEQ ID NO coding.The nucleotide sequence that term " HA gene " or " HA nucleotide sequence " comprise coding HA albumen, are made up of a coding region and corresponding untranslated 5 ' and 3 ' sequence area.The example of HA gene comprises those genes described in the table 1.Term " output " or " productivity " are well known in the art, are included in the concentration (for example per hour every liter kg product) of the tunning (for example required fine chemicals) that generates in preset time and the given fermentation volume.Term " productive rate " comprises the required time of specific production level to be reached (for example how long cell reaches specific fine chemicals output capacity needs).Term " yield " or " product/carbon yield " are well known in the art, comprise that carbon source is converted into the efficient of product (being fine chemicals).This is typically expressed as the kg product of for example every kg carbon source.By yield or the output that increases described compound, be increased in the amount of the recovery molecule of this compound in the culture of specified rate preset time or the amount of available recovery molecule.Term " biosynthesizing " or " biosynthetic pathway " are well known in the art, comprise cell can multistep suddenly and the compound that begins from midbody compound in the process of highly being regulated, preferably organic compound is synthetic.Term " degraded " or " degradation pathway " are well known in the art, comprise cell can be multistep suddenly and in the process of highly being regulated with compound, preferably organic compound is decomposed into degraded product (molecule that generally speaking, be less or complexity is lower).Term " metabolism " is well known in the art, comprises biological esoteric all biological chemical reaction.The metabolism of the specific compound amino acid whose metabolism of glycine (for example such as) comprises then that all biological relevant with this compound in the cell is synthetic, modification and degradation pathway.Term " stable state " is well known in the art, comprises how the used general born of the same parents' external environment condition of cell all can keep all mechanism of environment in the constant born of the same parents.The limiting examples of this class process is to utilize cell walls to prevent the infiltration cracking due to the high solute concentration in the born of the same parents.Term " adaptation " or " to the adaptation of envrionment conditions " are well known in the art, comprise that cell is used for making the cell can be in not preferred envrionment conditions (generally speaking, be those envrionment conditionss of one or more suitable nutrient deficiencies wherein, or wherein drop on envrionment conditions outside the suitableeest scope of cell such as temperature, pH, Osmolality, oxygen per-cent etc.) mechanism of survival.Many cells comprise that the Corynebacterium glutamicum cell has and are coded under this class envrionment conditions the proteinic gene of expressing and making its continued growth under the inferior suitable condition of this class.

In another embodiment, HA molecule of the present invention can be regulated for example for example generation of fine chemicals of desired molecule in the Corynebacterium glutamicum of microorganism.There is many mechanism to make the proteic change of HA of the present invention directly to influence to mix the proteic Corynebacterium glutamicum strain of this change to produce yield, output and/or the productive rate of fine chemicals.For example, undertaken engineered by enzyme to modification or degraded aromatics or aliphatic cpd, make the activity of these enzymes or quantity increase or reduce, might regulate generation as one or more fine chemicals of the modified outcome of these compounds or degraded product.Equally, the metabolic enzyme of participation mineral compound provides key molecule (for example phosphorus, sulphur and nitrogen molecule) for the biosynthesizing of the fine chemicals such as amino acid, VITAMIN and nucleic acid.By changing the activity or the quantity of these enzymes in the Corynebacterium glutamicum, might increase the conversion (or use substitute mineral compound) of these mineral compound, make the speed that inorganic atoms is mixed in these fine chemicals improve thus.The Corynebacterium glutamicum enzyme that participates in the ubiquity cell processes is carried out genetically engineered, also can directly improve the generation of fine chemicals, because the many enzymes in these enzymes are directly modified fine chemicals (for example amino acid) or participated in the synthetic or excretory enzyme of fine chemicals.The adjusting of pair cell protease activity or quantity also may have direct influence to the generation of fine chemicals, the enzyme that fine chemicals or participation fine chemicals produce or decompose because a lot of proteolytic enzyme can be degraded.

In addition, participating in aromatics/aliphatic cpd modification or degraded, general biocatalysis, mineral compound metabolism or proteoclastic above-mentioned enzyme itself all is fine chemicals, needs its activity in various external industrial application.By changing the copy number of the gene of one or more these enzymes in the Corynebacterium glutamicum, might increase these proteinic quantity that cell produces, improve extensive Corynebacterium glutamicum or Related Bacteria culture thus and produce these proteinic potential yield or productive rates.

The proteic change of HA of the present invention also may remote effect be mixed this class through changing yield, output and/or the productive rate of proteic Corynebacterium glutamicum strain production fine chemicals.For example, by cell walls makes up or those activity of proteins and/or the quantity of rearrangement are regulated to participating in, might modify the structure of cell walls itself, the mechanical stress that causes cell to withstand better to exist between the large scale fermentation incubation period and other stress.In addition, a large amount of cell walls of the extensive growth needs of Corynebacterium glutamicum produces.The activity or the quantity of pair cell wall biosynthetic enzyme or degrading enzyme are regulated, can be so that the biosynthetic speed of cell walls be quicker, this so can increase the cell quantity of producing required fine chemicals thus so that this microbial growth speed improves in the culture.

By modifying HA enzyme of the present invention, also can the remote effect Corynebacterium glutamicum produce yield, output or the productive rate of one or more fine chemicals.For example, many general enzymes have great effect to general (global) cell processes (for example regulate process) in the Corynebacterium glutamicum, this so that to fine chemicals metabolism has great effect.Equally, the enzyme of proteolytic enzyme, modification or toxicity aromatics of degrading possible or aliphatic cpd and the metabolic enzyme of promotion mineral compound all can be used to improve the viability of Corynebacterium glutamicum.The protein that these proteolytic enzyme help optionally to remove malfolding or regulate through mistake, for example those protein that under the envrionment conditions of the Metus compulsiva that may run between large scale fermentation jar incubation period, exist.By changing these protein, the viability that might further strengthen this activity and improve Corynebacterium glutamicum in the culture.Aromatics/aliphatic series is modified or degrade proteins not only can be used for these refuse compounds (these compounds may run into as the refuse of impurity in the substratum or cell self) detoxifcation, and allows cell the suitableeest carbon source in culture to have in limited time can to utilize alternative carbon source.By increasing its quantity and/or activity, the survival that can improve glutamic acid rod bacilli-cell in the culture.Inorganic metabolizable protein of the present invention is cell supply all proteins and the synthetic required inorganic molecule of Nucleotide (this is one of them), and therefore the total viability for cell is vital.Increase the quantity of producing the viable cell of one or more required fine chemicals in the large scale culturing thing, should cause improving simultaneously yield, output and/or productive rate that fine chemicals described in the described culture is produced.

Isolated nucleic acid sequences of the present invention is included in the genome of Corynebacterium glutamicum strain, and described bacterial strain can obtain by American type culture collection, and preserving number is ATCC13032.The nucleotide sequence of described isolating Corynebacterium glutamicum HA DNA and the predicted amino acid sequence of HOMEOSTASIS ADAPTATION PROTEIN are shown in respectively in the sequence table among the odd number SEQ ID NO and even number SEQ ID NO.Carry out computational analysis, with the classification of these nucleotide sequences and/or be accredited as the modification or the degraded of the metabolism, aromatics or the aliphatic cpd that participate in Corynebacterium glutamicum cell walls biosynthesizing or rearrangement, mineral compound or have the proteinic encoding sequence of a kind of Corynebacterium glutamicum enzymic activity or proteolytic activity.

The present invention also relates to the amino acid that had and aminoacid sequence of the present invention (for example sequence of the even number SEQ ID NO in the sequence table) homologous protein basically.Aminoacid sequence that has used herein and selected aminoacid sequence be homologous protein basically, with selected aminoacid sequence (for example described complete selected aminoacid sequence) at least about 50% homology.Aminoacid sequence that is had and selected aminoacid sequence be homologous protein basically, also can with selected aminoacid sequence have at least about 50-60%, preferably at least about 60-70%, more preferably at least about 70-80%, 80-90% or 90-95%, most preferably at least about 96%, 97%, 98%, 99% or higher homology.

HA albumen of the present invention or its biologically-active moiety or fragment can participate in keeping the Corynebacterium glutamicum homeostasis maybe can carry out the function that this microorganism of participation adapts to the varying environment condition, or has one or more activity described in the table 1.

All respects of the present invention are described in following trifle in further detail.

A. isolated nucleic acid molecule

One aspect of the present invention relates to the isolated nucleic acid molecule of coding HA polypeptide or its biologically-active moiety and is enough to be identified or the hybridization probe of amplification or the nucleic acid fragment of primer as HA coding nucleic acid (for example HA DNA).Term used herein " nucleic acid molecule " will be meant DNA or the RNA analogue that comprises dna molecular (for example cDNA or genomic dna) and RNA molecule (for example mRNA) and employing nucleotide analog deposits yields.This term also comprises the non-translated sequence that is positioned at gene coding region 3 ' end and 5 ' end: the sequence of downstream at least about 20 Nucleotide held in the sequence and the coding region 3 ' at least about 100 Nucleotide of gene coding region 5 ' end upstream.Described nucleic acid molecule can be strand or two strands, but double-stranded DNA preferably." isolating " nucleic acid molecule be with described nucleic acid natural origin in other nucleic acid molecule isolated nucleic acid molecule of existing.Preferably, " isolating " nucleic acid does not contain the sequence (promptly being positioned at described nucleic acid 5 ' end and the 3 ' sequence of holding) of the described nucleic acid of natural adjacency in the genomic dna of biology in described nucleic acid source.For example, in various embodiments, isolating HA nucleic acid molecule can contain the nucleotide sequence of the described nucleic acid molecule of natural adjacency in the genomic dna of the cell (for example Corynebacterium glutamicum cell) in described nucleic acid source less than about 5kb, 4kb, 3kb, 2kb, 1kb, 0.5kb or 0.1kb.In addition, " isolating " nucleic acid molecule, for example dna molecular can be substantially free of other cellular material, does not maybe contain substratum when producing by recombinant technology, or do not contain precursor or other chemical substance when chemosynthesis.

Nucleic acid molecule of the present invention for example has nucleic acid molecule or its part of odd number SEQ ID NO nucleotide sequence in the sequence table, can separate with sequence information provided herein with standard molecular biological technique.For example, can be with the full sequence of one of odd number SEQ ID NO sequence in the sequence table or partial sequence as hybridization probe, (for example adopt with the standard hybridization technique, be described in the technology of following document: Sambrook, J., Fritsh, E.F. and Maniatis, T.MolecularCloning:A Laboratory Manual. the 2nd edition, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989), can from the Corynebacterium glutamicum library, isolate Corynebacterium glutamicum HA DNA.In addition, the nucleic acid molecule that comprises all or part of sequence of one of nucleotide sequence of the present invention (for example odd number SEQ ID NO), can adopt Oligonucleolide primers based on this sequences Design, separate (nucleic acid molecule (for example odd number SEQ ID NO of sequence table) that for example, comprises all or part of sequence of one of nucleotide sequence of the present invention can adopt the Oligonucleolide primers based on the design of described sequence to separate by the polymerase chain reaction) by the polymerase chain reaction.For example, can be from normal endotheliocyte separating mRNA (for example by (1979) Biochemistry 18:5294-5299 such as Chirgwin isothiocyanic acid Guanidinium extraction process), (for example Moloney MLV ThermoScript II can derive from Gibco/BRL to use ThermoScript II then, Bethesda, MD; Or the AMV ThermoScript II, can derive from SeikagakuAmerica, Inc., St.Petersburg, FL) preparation DNA.Can be designed for the synthetic oligonucleotide primer thing of polymerase chain reaction (PCR) amplification based on one of nucleotide sequence shown in the sequence table.As template, with suitable Oligonucleolide primers, according to Standard PC R amplification technique, nucleic acid of the present invention can increase with cDNA or genomic dna.The nucleic acid clone of so amplification in suitable carriers, and is identified by dna sequence analysis.In addition, can pass through the standard synthetic technology, for example prepare with automatic dna synthesizer corresponding to the oligonucleotide of HA nucleotide sequence.

In a preferred embodiment, isolated nucleic acid molecule of the present invention comprises the nucleotide sequence shown in a kind of sequence table.Nucleotide sequence of the present invention shown in the sequence table is corresponding to Corynebacterium glutamicum HA DNA of the present invention.This DNA comprises sequence and the 5 ' non-translated sequence and the 3 ' non-translated sequence of coding HA albumen (promptly being shown in " coding region " in the sequence table odd number SEQ ID NO sequence respectively), and described non-translated sequence also is shown in respectively among the odd number SEQ ID NO in the sequence table.On the other hand, described nucleic acid molecule can only comprise the coding region of arbitrary sequence in the sequence table nucleotide sequence.

In order to carry out this application, people will appreciate that, every kind of nucleotide sequence shown in the sequence table and aminoacid sequence have sign property RXA, RXN, RXS or RXC numbering, meet identifier " RXA ", " RXN ", " RXS " or " RXC " (being RXA02458, RXN00249, RXS00153 or RXC00963) of 5 bit digital after described numbering has.Every kind of described nucleotide sequence comprises three parts at the most: one 5 ' upstream, a coding region and a catchment.Each district in these three districts differentiates by identical RXA, RXN, RXS or RXC identifier, to avoid confusion.Narration " one of odd number sequence in the sequence table " then is meant arbitrary nucleotide sequence in the sequence table, and it also can be distinguished according to its different RXA, RXN, RXS or RXC identifier.The coding region of each sequence in these sequences is translated into amino acid sequence corresponding, and described aminoacid sequence also is shown in the sequence table, as being right after corresponding nucleic sequence even number SEQ ID NO afterwards.For example, the coding region of RXA02548 is shown among the SEQ ID NO:1, and its amino acid sequence coded is shown among the SEQ ID NO:2.The sequence of nucleic acid molecule of the present invention is differentiated according to RXA, RXN, RXS or the RXC identifier identical with their coded amino acid moleculars, makes and can easily they be interrelated.For example, the aminoacid sequence of RXA02458, RXN00249, RXS00153 and RXC00963 by name is respectively the translation thing in nucleic acid molecule RXA02458, RXN00249, RXS00153 and the nucleotide sequence coded district of RXC00963.Corresponding relation between RXA of the present invention, RXN, RXS and RXC nucleotide sequence and aminoacid sequence and its specified SEQ ID NO is shown in Table 1.

Several gene of the present invention is " gene of F sign ".The gene of F sign comprises those genes that had " F " before RXA, RXN, RXS or RXC identifier shown in the table 1.For example, the SEQ ID NO:5 that is appointed as " F RXA00249 " in table 1 is a kind of gene of F sign, and SEQ ID NO:11,15 and 33 (being appointed as " F RXA02264 ", " F RXA02274 " and " F RXA00675 " in table 1 respectively) also is like this.

In one embodiment, nucleic acid molecule of the present invention is not meant those nucleic acid molecule that comprise table 2 inediting.With regard to the dapD gene, the sequence of this gene is published in Wehrmann, A. etc. (1998) J.Bacteriol.180 (12): among the 3159-3165.Yet the sequence that the present application people obtains is significantly long than the form of being announced.Think that the form of being announced depends on incorrect initiator codon, therefore only represent a fragment of true coding region.

In another preferred embodiment, isolated nucleic acid molecule of the present invention comprises nucleic acid molecule or its part as the complementary sequence of one of nucleotide sequence of the present invention (for example odd number SEQ ID NO sequence in the sequence table).As the nucleic acid molecule of the complementary sequence of one of nucleotide sequence among the present invention be enough complementary with one of nucleotide sequence shown in the sequence table (for example odd number SEQ ID NO sequence), make and can and therefore form the nucleic acid molecule of stablizing duplex with the hybridization of one of nucleotide sequence of the present invention.

In a preferred embodiment again, isolated nucleic acid molecule of the present invention comprises such nucleotide sequence or its part, the homology of described nucleotide sequence and nucleotide sequence of the present invention (for example odd number SEQ ID NO sequence in the sequence table) is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher.The present invention also comprises the scope and sign numerical value (for example 70-90% is identical or 80-95% identical) between the above-mentioned numerical value.For example, will comprise the ident value scope of above-mentioned value that adopt as any combination of the upper limit and/or lower limit.In another preferred embodiment, isolated nucleic acid molecule of the present invention comprises nucleotide sequence or its part with the hybridization of one of nucleotide sequence of the present invention, for example hybridize under stringent condition.

In addition, nucleic acid molecule of the present invention can only comprise the part in a kind of odd number SEQ IDNO sequence encoding district in the sequence table, for example can be as the fragment of probe or primer or the fragment of the proteic biologically-active moiety of coding HA.According to the nucleotide sequence of measuring from Corynebacterium glutamicum clone HA gene, make to produce to be designed for the HA homologue of identifying and/or cloning in other cell type and the biology and from the probe and the primer of the HA homologue of other excellent bacillus or relevant bacterial classification.Described probe/primer comprises the oligonucleotide of purifying basically usually.Described oligonucleotide comprises a kind of nucleotide sequence district usually, described nucleotide sequence district under stringent condition with the antisense sequences of one of the sense strand of one of nucleotide sequence of the present invention (for example a kind of odd number SEQ ID NO sequence in the sequence table), these sequences or its naturally occurring mutant at least about 12, preferred about 25, more preferably from about 40,50 or 75 continuous nucleotides hybridization.Primer based on nucleotide sequence of the present invention can be used for the PCR reaction, with clone HA homologue.Can be used for detecting the transcript or the genome sequence of same albumen of coding or homologous protein based on the probe of described HA nucleotide sequence.In preferred embodiments, described probe also comprises a connected labelling groups, and for example described labelling groups can be radio isotope, fluorescent chemicals, enzyme or enzyme cofactor.This class probe can be as the part of diagnostic test test kit, to identify the proteic cell of false demonstration (misexpress) HA, for example by measuring the level of HA coding nucleic acid in the cell sample, for example detect HA mRNA level or detect genome HA gene and whether suddenly change or lack.

In one embodiment, nucleic acid molecule encoding of the present invention is a kind of to comprise protein or its part with the enough homologous aminoacid sequences of aminoacid sequence of the present invention (for example even number SEQ ID NO sequence in the sequence table), makes described protein or its part keep to participate in keeping the Corynebacterium glutamicum homeostasis or carries out the ability that participates in the function that this microorganism adapts to the varying environment condition.Term used herein " enough homologies " is meant such protein or its part, described protein or the aminoacid sequence that its part had comprise the identical with aminoacid sequence of the present invention of minimal number or are equal to (for example similar amino-acid residue of amino-acid residue in a kind of even number SEQ ID NO sequence in the side chain that is had and the sequence table) amino-acid residue, make described protein or its part can participate in keeping the Corynebacterium glutamicum homeostasis or carry out and participate in the function that this microorganism adapts to the varying environment condition.Participate in Corynebacterium glutamicum cell walls biosynthesizing or rearrangement, mineral compound metabolism, aromatics or aliphatic cpd modification or degraded or have the protein of a kind of Corynebacterium glutamicum enzymic activity as herein described or proteolytic activity, working aspect the production of one or more fine chemicals and the secretion.The active example of this class has also been described in this article.Therefore, " the proteic function of HA " or influence yield, output and/or the productive rate that one or more fine chemicals are produced directly or indirectly.The example of HA protein-active is shown in Table 1.

In another embodiment, the homology of described protein and complete amino acid sequence of the present invention (for example sequence table even number SEQ ID NO sequence) is at least about 50-60%, preferably at least about 60-70%, more preferably at least about 70-80%, 80-90%, 90-95%, most preferably at least about 96%, 97%, 98%, 99% or higher.

The proteic biologically-active moiety of preferably a kind of described HA of proteinic part that HA nucleic acid molecule of the present invention is coded.Term used herein " the proteic biologically-active moiety of HA " will comprise that can participate in keeping the Corynebacterium glutamicum homeostasis maybe can carry out the HA proteic part of this microorganism of participation to the function of varying environment condition adaptation, structural domain/motif for example, or have a kind of activity described in the table 1.For determine HA albumen or its biologically-active moiety whether can participate in the biosynthesizing of Corynebacterium glutamicum cell walls or rearrangement, mineral compound metabolism, aromatics or aliphatic cpd modification or degraded or have a kind of Corynebacterium glutamicum enzymic activity or proteolytic activity, can carry out the mensuration of enzymic activity.This class measuring method is that those skilled in the art are well-known, as what describe in detail among the embodiment 8 of embodiment part.

By separating the part of a kind of aminoacid sequence of the present invention (for example even number SEQ ID NO sequence in the sequence table), express the part (for example passing through in-vitro recombination expression) of coded described HA albumen or peptide, and estimate the coded described HA albumen or the activity of peptide moiety, can prepare the nucleic acid fragment of other coding HA protein biological activity part.

The present invention comprises that also the degeneracy owing to genetic code is different from one of nucleotide sequence of the present invention (for example odd number SEQ ID NO sequence in the sequence table) (with its part) and the HA proteic nucleic acid molecule identical with the coded albumen of nucleotide sequence of the present invention of therefore encoding.In another embodiment, the nucleotide sequence coded protein that isolated nucleic acid molecule of the present invention had with aminoacid sequence shown in the sequence table (for example even number SEQ ID NO).In an embodiment again, nucleic acid molecule encoding of the present invention and aminoacid sequence of the present invention (by the coding of the open reading-frame (ORF) shown in the odd number SEQ ID NO in the sequence table) be homologous total length Corynebacterium glutamicum albumen basically.

Skilled person in the art will appreciate that in one embodiment sequence of the present invention does not mean that the sequence that comprises prior art, for example those sequences of the Genbank sequence that before the present invention, obtains of narration in the table 2 or 4.In one embodiment, the present invention includes the identity per-cent that has with nucleotide sequence of the present invention or aminoacid sequence nucleotide sequence and aminoacid sequence greater than the identity per-cent of prior art sequence (for example Genbank sequence of narration in the table 2 or 4 protein of this sequence encoding (or by)).For example, the present invention includes: with the identity of the nucleotide sequence of RXA00471 by name (SEQ ID NO:293) greater than 39% and/or be at least 39% nucleotide sequence; With the identity of the nucleotide sequence of RXA00500 by name (SEQ ID NO:143) greater than 41% and/or be at least 41% nucleotide sequence; And with the identity of the nucleotide sequence of RXA00502 by name (SEQ ID NO:147) greater than 35% and/or be at least 35% nucleotide sequence.Those skilled in the art are by checking three identity per-cent score values that hit the calculating of GAP shown in the table 4 separately the highest of any given sequence of the present invention, and from 100%, deduct the highest identity per-cent score value that GAP calculates, can calculate the lower limit of described given sequence identity per-cent of the present invention.Those skilled in the art also will appreciate that, the present invention comprises that also identity per-cent is greater than the lower limit that so calculates (identity at least 50% for example, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher) nucleotide sequence and aminoacid sequence.

In sequence table, the Corynebacterium glutamicum HA Nucleotide shown in the odd number SEQ ID NO, those of skill in the art will recognize that in colony (for example Corynebacterium glutamicum colony), to have the dna sequence polymorphism that causes HA Argine Monohydrochloride sequence to change.Because natural variation, the genetic polymorphism in the described HA gene of this class may be present in the individuality of colony.Term used herein " gene " and " recombination " are meant and comprise coding HA albumen, the nucleic acid molecule of the open reading-frame (ORF) of HOMEOSTASIS ADAPTATION PROTEIN preferably.This class natural variation can cause the variation of 1-5% in the described HA gene nucleotide series usually.Because the result of natural variation and any and all these class nucleotide diversities that do not change among the active HA of HA protein function will be included in the scope of the present invention with the amino acid polymorphism that is produced.

According to natural variation body and the nucleic acid molecule of non-glutamic acid rod bacillus homologue and the homology of Corynebacterium glutamicum HA nucleic acid disclosed herein corresponding to Corynebacterium glutamicum HA DNA of the present invention, adopt described Corynebacterium glutamicum DNA or its part as under the stringent hybridization condition according to the hybridization probe of standard hybridization technique, can isolate described nucleic acid molecule.Therefore, in another embodiment, isolated nucleic acid molecule of the present invention is to 15 Nucleotide of the youthful and the elderly, and under stringent condition with the making nucleic acid molecular hybridization that comprises odd number SEQ ID NO nucleotide sequence in the sequence table.In other embodiments, described nucleic acid is to 30 of the youthful and the elderlys, 50,100,250 or more a plurality of Nucleotide.Term used herein " hybridize under stringent condition " is intended to describe hybridization and the wash conditions that at least 60% homologous nucleotide sequence each other keeps the phase mutual cross usually.Preferably, described condition make each other homology be at least about 65%, more preferably at least about 70% in addition more preferably at least about 75% or higher sequence keep the phase mutual cross usually.This class stringent condition is well known by persons skilled in the art, and can be at CurrentProtocols in Molecular Biology, John Wiley ﹠amp; Sons, N.Y. (1989) finds among the 6.3.1-6.3.6.A preferred limiting examples of stringent hybridization condition be in 6X sodium chloride/sodium citrate (SSC) in about 45 ℃ of hybridization, then at 0.2 X SSC, carry out one or many washing in 50-65 ℃ among 0.1% SDS.Preferably, under stringent condition with the isolated nucleic acid molecule of the present invention of nucleotide sequence hybridization of the present invention corresponding to naturally occurring nucleic acid molecule." naturally occurring " used herein nucleic acid molecule is meant the have naturally occurring nucleotide sequence RNA or the dna molecular of (natural protein of for example encoding).In one embodiment, a kind of natural HOMEOSTASIS ADAPTATION PROTEIN of described nucleic acid encoding.

Except the naturally occurring varient of the described HA sequence that in colony, may exist, those skilled in the art also will appreciate that, can import change by in nucleotide sequence of the present invention, suddenling change, cause the change of coded HA Argine Monohydrochloride sequence thus, and do not change the proteic Functional Capability of described HA.For example, can in Nucleotide of the present invention, cause replacing at the Nucleotide of " nonessential " amino-acid residue upper amino acid replacement." nonessential " amino-acid residue is can be changed in the wild-type sequence (for example even number SEQ ID NO of sequence table) of one of described HA albumen and do not change the residue of described HA protein-active, and " essential " amino-acid residue is that the HA protein-active is required.Yet other amino-acid residue (for example conservative or only semiconservative those residues in having HA active structures territory) may not be active essential, therefore may be fit to change and does not change the HA activity.

Therefore, another aspect of the present invention relates to coding HA albumen, contains the nucleic acid molecule that the active nonessential amino-acid residue of HA changes.This class HA albumen is different from the sequence of even number SEQ ID NO in the sequence table on aminoacid sequence, but still keeps at least a HA activity as herein described.In one embodiment, described isolated nucleic acid molecule comprises the nucleotide sequence of coded protein, wherein said protein comprise with aminoacid sequence of the present invention at least about 50% homologous aminoacid sequence, and can participate in keeping the Corynebacterium glutamicum homeostasis or carry out participating in the function that this microorganism adapts to the varying environment condition, or have one or more activity described in the table 1.Preferably, the aminoacid sequence of a kind of odd number SEQ ID NO is at least about the 50-60% homology in the protein of described nucleic acid molecule encoding and the sequence table, more preferably with one of these sequences at least about the 60-70% homology, even more preferably with one of these sequences at least about 70-80%, 80-90%, 90-95% homology, most preferably with a kind of aminoacid sequence of the present invention at least about 96%, 97%, 98% or 99% homology.

In order to determine the percent homology of two seed amino acid sequences (for example a kind of aminoacid sequence of the present invention and its mutant forms) or two kinds of nucleic acid, described sequence is carried out sequence alignment, to carry out best the comparison (for example can introduce the room) to carry out the optimal sequence comparison with another kind of protein or nucleic acid in the sequence of a kind of protein or nucleic acid.Amino-acid residue or Nucleotide on more corresponding then amino acid position or the nucleotide position.When a position in the sequence (for example a kind of aminoacid sequence of the present invention) was occupied by the same amino-acid residue of corresponding position in another sequence (for example mutant forms of described aminoacid sequence) or Nucleotide, then described two kinds of molecules were homologous (being that amino acid used herein or nucleic acid " homology " are equal to amino acid or nucleic acid " identity ") in this position.The same position number that percent homology between these two sequences is shared with described sequence changes (being percent homology=same position number/total number of positions * 100).

Code book invention protein sequence (for example even number SEQ ID NO sequence in the sequence table) the proteic isolated nucleic acid molecule of homologous HA can make up by following steps: in nucleotide sequence of the present invention, import one or more Nucleotide and replace, add or disappearance, make in coded protein, to import one or more aminoacid replacement, interpolation or disappearance.Can adopt standard technique, for example site-directed mutagenesis and PCR mediated mutagenesis, will suddenly change imports in a kind of nucleotide sequence of the present invention.Preferably, carrying out conserved amino acid on the non-essential amino acid residue of one or more predictions replaces." conserved amino acid replacement " is the aminoacid replacement that wherein said amino-acid residue is had an amino-acid residue replacement of similar side chain.Determined to have the amino-acid residue classification of similar side chain in the art.These classifications comprise amino acid with basic side chain (Methionin for example, arginine, Histidine), amino acid (aspartic acid for example with acid side-chain, L-glutamic acid), amino acid (glycine for example with uncharged polar side chain, l-asparagine, glutamine, Serine, Threonine, tyrosine, halfcystine), amino acid (L-Ala for example with non-polar sidechain, Xie Ansuan, leucine, Isoleucine, proline(Pro), phenylalanine, methionine(Met), tryptophane), amino acid (Threonine for example with β-branched building block, Xie Ansuan, Isoleucine) and amino acid (tyrosine for example with aromatic side chains, phenylalanine, tryptophane, Histidine).Therefore, the non-essential amino acid residue of predicting in the HA albumen is preferably replaced by the another kind of amino-acid residue from same side chain classification.Perhaps, in another embodiment, can import sudden change at random, for example import sudden change by saturation mutagenesis along all or part of HA encoding sequence, and can screen the mutant that is produced according to HA activity as herein described, keep the active mutant of HA to identify.After the nucleotide sequence mutagenesis to one of odd number SEQ ID NO in the sequence table, can recombinant expressed coded protein, can adopt mensuration for example as herein described (referring to the embodiment 8 of embodiment part) to measure described activity of proteins then.

Except the proteic nucleic acid molecule of above-mentioned coding HA, another aspect of the present invention relates to the isolated nucleic acid molecule of antisense." antisense " nucleic acid comprises " justice is arranged " nucleic acid complementary nucleotide sequence with coded protein, for example with the coding strand of double chain DNA molecule complementary or with mRNA sequence complementary nucleotide sequence.Therefore, antisense nucleic acid can form hydrogen bond with phosphorothioate odn is arranged.

Described antisense nucleic acid and complete HA coding strand or only with its part complementation.In one embodiment, antisense nucleic acid molecule is the antisense nucleic acid molecule of " coding region " of the proteic nucleotide sequence coded chain of coding HA.Term " coding region " is meant the nucleotide sequence district (for example the complete coding region of SEQ ID NO:3 (RXN00249) comprises Nucleotide 1-957) that comprises the codon that is translated into amino-acid residue.In another embodiment, described antisense nucleic acid molecule is the antisense nucleic acid molecule of the nucleotide sequence coded chain " non-coding region " of coding HA.Term " non-coding region " is meant in abutting connection with described coding region, is not translated into amino acid whose 5 ' sequence and 3 ' sequence (promptly being also referred to as 5 ' and 3 ' non-translational region).

The coding strand sequence (for example sequence shown in the odd number SEQID NO in the sequence table) of known coding HA disclosed herein therefore can design antisense nucleic acid of the present invention according to Waston and Crick basepairing rule.Described antisense nucleic acid molecule can with the complete coding region complementation of HA mRNA, but be more preferably oligonucleotide as the antisense molecule of a HA mRNA coding region only or a non-coding region part.For example, described antisense oligonucleotide can with HA mRNA translation initiation site around regional complementarity.Described antisense oligonucleotide can for example be about 5,10,15,20,25,30,35,40,45 or 50 Nucleotide.The enzyme ligation that can adopt chemosynthesis and adopt methods known in the art makes up antisense nucleic acid of the present invention.For example, can be with naturally occurring Nucleotide or design in order to increase described molecular biology stability or to increase described antisense nucleic acid and the Nucleotide of the various modifications of formed duplex physical stability between the phosphorothioate odn is arranged, chemosynthesis antisense nucleic acid (for example antisense oligonucleotide), the Nucleotide that for example can use thiophosphoric acid derivative and acridine to replace.The example that can be used for producing the modified Nucleotide of described antisense nucleic acid comprises 5 FU 5 fluorouracil, 5-bromouracil, the 5-chlorouracil, 5-iodouracil, xanthoglobulin, xanthine, the 4-acetylcytosine, 5-(carboxyl hydroxymethyl) uridylic, 5-carboxymethylamino methyl-2-thio uridine, 5-carboxymethylamino 6-Methyl Uracil, dihydrouracil, β-D-galactosyl Q nucleosides (queosine), inosine, the N6-isopentenyl gland purine, the 1-methyl guanine, the 1-methylinosine, 2, the 2-dimethylguanine, the 2-methyladenine, the 2-methyl guanine, the 3-methylcystein, 5-methylcytosine, the N6-VITAMIN B4, the 7-methyl guanine, 5-methylamino 6-Methyl Uracil, 5-methoxyl group amino methyl-2-thiouracil, β-D-mannose group Q nucleosides, 5 '-methoxyl group carboxyl 6-Methyl Uracil, the 5-methoxyuracil, 2-methylthio group-N6-isopentenyl gland purine, uridylic-the 5-oxyacetic acid (v), wybutoxosine, pseudouracil, the Q nucleosides, 2-sulfo-cytosine(Cyt), 5-methyl-2-thiouracil, the 2-thiouracil, the 4-thiouracil, methyl uracil, uridylic-5-hydroxy methyl acetate, uridylic-the 5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxylic propyl group) uridylic, (acp3) w and 2,6-diaminopurine.On the other hand, can adopt with the antisense orientation subclone a kind of nucleic acid (promptly the RNA that goes out by the transcribed nucleic acid that is inserted will have the antisense orientation of interested target nucleic acid, in following trifle, further describe) expression vector, produce described antisense nucleic acid with biological method.

Usually give cell with antisense nucleic acid molecule of the present invention or its original position is produced, make them with the hybridization of the coding proteic cell mRNA of HA and/or genomic dna or combine, to suppress described proteic expression thus, for example express by suppressing to transcribe and/or translate inhibition.Can hybridize by the Nucleotide complementarity of routine, forming stable duplex, or for example with the situation of DNA duplex bonded antisense nucleic acid molecule under, by the specific interaction in the duplex tap drain, and hybridize.Can modify described antisense molecule, make it, and be incorporated into the acceptor or the antigen of selected cell surface expression specifically for example by making described antisense nucleic acid molecule and be incorporated into cell surface receptor or antigenic peptide or antibody and be connected.Also can described antisense nucleic acid molecule be passed to cell with carrier described herein.In order to obtain the described antisense molecule of enough intracellular concentrations, preferred wherein said antisense nucleic acid molecule places the vector construction body under strong prokaryotic organism, virus or the promoter in eukaryote control.

In an embodiment again, antisense nucleic acid molecule of the present invention is α-a confer nucleic acid molecule.α-different nucleic acid molecule and complementary RNA form specific double-stranded crossbred, and be wherein opposite with common β unit, described chain complementation parallel (Gaultier etc. (1987) Nucleic Acids.Res.15:6625-6641).Described antisense nucleic acid molecule also can comprise 2 '-o-methyl ribonucleotides (Inoue etc. (1987) Nucleic Acids Res.15:6131-6148) or chimeric RNA-DNA analogue (Inoue etc. (1987) FEBS Lett.215:327-330).

In yet another embodiment, antisense nucleic acid of the present invention is a kind of ribozyme.Ribozyme is the catalytic RNA molecule with ribonuclease activity, and they can cut the single-chain nucleic acid that has complementary district with it, for example mRNA.Therefore, can (for example hammerhead ribozyme (being described in Haselhoff and Gerlach (1988) Nature 334:585-591) comes catalyze cleavage HA mRNA transcript, suppresses the translation of HA mRNA thus with ribozyme.Can be according to the nucleotide sequence (being SEQ ID NO.3 (RXN00249)) of HA dna molecular disclosed herein, design has specific ribozyme to the HA coding nucleic acid.For example, can make up the derivative of a kind of tetrahymena (Tetrahymena) L-19 IVS RNA, wherein nucleotide sequence complementation to be cut among the nucleotide sequence of reactive site and the HA coding mRNA.U.S. Patent number 5,116,742 referring to the U.S. Patent number 4,987,071 of for example Cech etc. and Cech etc.Perhaps, can use HAmRNA, from the RNA library of molecules, select to have the active catalytic RNA of particular core ribonuclease T..Referring to for example Bartel, D. and Szostak, J.W. (1993) Science 261:1411-1418.

On the other hand, by target and HA nucleotide sequence regulatory region (for example HA promotor and/or enhanser) complementary nucleotide sequence,, can suppress the HA expression of gene to form the triple-helix structure that stops HA genetic transcription in the target cell.Generally referring to Helene, C. (1991) Anticancer Drug Des.6 (6): 569-84; Helene, C. etc. (1992) Ann.N.Y.Acad.Sci.660:27-36; And Maher, L.J. (1992) Bioassays 14 (12): 807-15.

B. recombinant expression vector and host cell

Another aspect of the present invention relates to the carrier of the nucleic acid that contains coding HA albumen (or its part), preferred expression carrier.Term used herein " carrier " is meant the nucleic acid molecule that can transport connected another kind of nucleic acid.One type carrier is " plasmid ", and plasmid is meant the circular double stranded DNA ring that wherein can connect other DNA section.The carrier of another kind of type is a virus vector, wherein other DNA section can be connected in the viral genome.Some carrier can be in the host cell that they imported self-replicating (bacteria carrier and the additive type Mammals carrier that for example have the bacterium replication orgin).Other carrier (for example non-add type Mammals carrier) is incorporated in the genome of host cell after in importing to host cell, duplicates with host genome thus.In addition, some carrier can instruct and its expression of gene that effectively is connected.This class carrier is referred to herein as " expression vector ".Generally speaking, the expression vector that uses in recombinant DNA technology is the carrier of plasmid form normally.In this manual, " plasmid " and " carrier " can exchange use, because plasmid is the carrier format of normal use.Yet the present invention will comprise the expression vector of this other form of class, virus vector (for example replication defect type retrovirus, adenovirus and adeno-associated virus) for example, the function that their performances are equal to.

Recombinant expression vector of the present invention comprises the nucleic acid of the present invention that is suitable for expressing the form of nucleic acid of the present invention in host cell, this is meant that described recombinant expression vector comprises one or more adjusting sequences of selecting according to the host cell that is used to express, and described adjusting sequence effectively is connected in nucleotide sequence to be expressed.In recombinant expression vector, " effectively connecting " is meant the interested nucleotide sequence of institute is connected in described adjusting sequence in the mode that allows described nucleotide sequence to express (for example in in-vitro transcription/translation system maybe when with described carrier importing host cell in described host cell).Term " adjusting sequence " will comprise promotor, enhanser and other expression controlling elements (for example polyadenylation signal).This class is regulated sequence description in for example Goeddel; Gene Expression Technology:Methods in Enzymology 185, AcademicPress, San Diego, CA (1990).Regulate sequence and be included in those those adjusting sequences of regulating sequence and in some host cell, instructing described nucleotide sequence to express that instruct the nucleotide sequence constitutive expression in many type host cells.The preferred sequence of regulating is for example promotor, for example cos-, tac-, trp-, tet-, trp-tet, lpp-, lac-, lpp-lac, lacI ^q-, T7-, T5-, T3-, gal-, trc-, ara-, SP6-, arny, SPO2, λ-P _R-or λ P _L, they are preferred in the bacterium.Other regulates sequence is for example from the promotor of yeast and fungi, for example ADC1, MF α, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH; From the promotor of plant, for example CaMV/35S, SSU, OCS, lib4, usp, STLS1, B33, no or ubiquitin promotor or phaseolin promoter.Also might use artificial promotor.Those of skill in the art will recognize that the design of described expression vector can be depending on the factor of the selection such as host cell to be transformed, the expression level of desirable proteins etc.Expression vector of the present invention can be imported in the host cell, produce protein or peptide thus, comprise fusion rotein or peptide (for example the HA albumen of HA albumen, mutant form, fusion rotein etc.) by nucleic acid encoding as herein described.

Can design recombinant expression vector of the present invention is used for expressing HA albumen at prokaryotic cell prokaryocyte or eukaryotic cell.For example, can bacterial cell for example Corynebacterium glutamicum, insect cell (use rhabdovirus expression vector), yeast and other fungal cell (referring to Romanos, M.A. etc. (1992) " exogenous gene expression in the yeast: summary ", Yeast 8:423-488; Van den Hondel, C.A.M.J.J. etc. (1991) " allogeneic gene expression in the filamentous fungus ", be stated from: More GeneManipulations in Fungi, J.W.Bennet and L.L.Lasure write, the 396-428 page or leaf: Academic Press:San Diego; With van den Hondel, C.A.M.J.J. and Punt, P.J. (1991), " be used for gene transfer system and the carrier exploitation of filamentous fungus ", be stated from: AppliedMolecular Genetics of Fungi, Peberdy, J.F. wait and write, the 1-28 page or leaf, CambridgeUniversity Press:Cambridge), algae and metaphyte cell are (referring to Schmidt, R. and Willmitzer, L. (1988) " Arabidopis thaliana (Arabidopsis thaliana) of efficient agrobacterium tumefaciens (Agrobacterium tumefaciens) mediation and conversion of cotyledon explant " Plant CellRep.:583-586) or in the mammalian cell, expression HA gene.Proper host cell is at Goeddel, Gene Expression Technology:Methods in Enzymology 185, and Academic Press, San Diego, CA has further description in (1990).Perhaps, described recombinant expression vector can for example transcribe and translate with T7 promotor adjusting sequence and T7 polysaccharase external.

Protein expression in the prokaryotic organism is the most frequently used to contain the composing type of guidance or fusion rotein or non-expressing fusion protein or the carrier of inducible promoter carries out.Fusion vector adds to a plurality of amino acid on the wherein coded albumen, adds to the N-terminal of described recombinant protein usually, but also adds to C-terminal, or merges in the suitable district in described protein.This class fusion vector is generally used for three purposes: 1) in order to increase Recombinant Protein Expression; 2) in order to increase the solvability of described recombinant protein; With 3) for by help the purifying of described recombinant protein as the part in the affinity purification.Usually, in fusion expression vector, introduce a proteolytic enzyme cutting site at the contact place of merging part and recombinant protein, so that recombinant protein and fusion part can be separated, with the described fusion rotein of subsequent purificn.This fermentoid and relevant recognition sequence thereof comprise factor Xa, zymoplasm and enteropeptidase.

Typical fusion expression vector comprises pGEX (Pharmacia Biotech Inc; Smith, D.B. and Johnson, K.S. pMAL (New EnglandBiolabs (1988) Gene 67:31-40),, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ), they respectively with glutathione S-transferase (GST), maltose E is conjugated protein or A albumen and target recombinant protein merge.In one embodiment, the proteic encoding sequence of described HA is cloned in the pGEX expression vector, to produce the carrier of encoding fusion protein, described fusion rotein comprises GST-zymoplasm cleavage site-X protein from N-terminal to C-terminal.Described warm albumen can pass through affinitive layer purification with gsh-agarose resin.The reorganization HA albumen with the GST fusion can not reclaim by cut described fusion rotein with zymoplasm.

The example of the non-fusion coli expression carrier of suitable induction type comprises pTrc (Amann etc., (1988) Gene 69:301-315), pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN-III113-B1, λ gt11, pBdC1 and pET 11d (Studier etc., GeneExpression Technology:Methods in Enzymology 185, Academic Press, SanDiego, California (1990) 60-89; Write (1985) Cloning Vectors.Elsevier:New York IBSN 0 444 904018 with Pouwels etc.).Depend on from the host RNA polysaccharase of hybrid trp-lac promoter, fusion from the target gene expression of pTrc carrier and to transcribe.Depend on the transcribing of T7gn10-lac promoter, fusion of viral rna polymerase (T7gn1) mediation by co expression from the target gene expression of pET11d carrier.This varial polymerases is by host strain BL21 (DE3) or HMS174 (DE3) supply from residence (resident) the λ prophage that contains the T7gnl gene under the control of lacUV5 promoter transcription.About the conversion of other bacterium mutation, can select suitable carriers.For example, known plasmid pIJ101, pIJ364, pIJ702 and pIJ361 can be used for transforming streptomyces (Streptomyces), and plasmid pUB110, pC194 or pBD214 are applicable to that transforming bacillus belongs to (Bacillus) bacterial classification.Several plasmids that are used for genetic information is transferred to Corynebacterium comprise pHM1519, pBL1, pSA77 or pAJ667 (Pouwels etc. write (1985) Cloning Vectors.Elsevier:New York IBSN 0 444904018).

Making the maximized a kind of strategy of expression of recombinant proteins is to express described albumen (Gottesman in the impaired host bacteria of the described recombinant protein ability of proteolytic cleavage, S., GeneExpression Technology:Methods in Enzymology 185, Academic Press, SanDiego, California (1990) 119-128).Another kind of strategy is to change the nucleotide sequence that is inserted into the nucleic acid in the expression vector, makes that each amino acid whose each codon is at the preferential codon (Wada etc. (1992) Nucleic Acids Res.20:2111-2118) that uses of the selected bacterium (for example Corynebacterium glutamicum) that is used for expressing.The change of this nucleotide sequence of the present invention can be carried out with the standard DNA synthetic technology.

In another embodiment, described HA protein expression vector is a kind of Yeast expression carrier.The example that is used for the carrier of expressing at yeast yeast saccharomyces cerevisiae (S.cerevisiae) comprises pYepSec1 (Baldari etc. (1987) Embo J.6:229-234), 2 μ, pAG-1, Yep6, Yep13, pEMBLYe23, pMFa (Kurjan and Herskowitz (1982) Cell 30:933-943), pJRY88 (Schultz etc., Gene 54:113-123) and pYES2 (InvitrogenCorporation (1987), San Diego, CA).Be applicable to other fungi for example carrier and the construction of carrier of filamentous fungus be included in carrier and the method that describes in detail in the following document: van denHondel, C.A.M.J.J. and Punt, P.J. (1991) " are used for gene transfer system and the carrier exploitation of filamentous fungus ", be stated from: Applied Molecular Genetics of Fungi, J.F.Peberdy etc. write, the 1-28 page or leaf, Cambridge University Press:Cambridge and Pouwels etc. write (1985) Cloning Vectors.Elsevier:New York (IBSN 0 444904018).

On the other hand, HA albumen of the present invention can be with rhabdovirus expression vector in expressed in insect cells.The baculovirus vector that is used in the middle expressing protein of insect cell (for example Sf9 cell) of cultivation comprises pAc series (Smith etc. (1983) Mol.Cell Biol.3:2156-2165) and pVL series (Lucklow and Summers (1989) Virology 170:31-39).

In another embodiment, HA albumen of the present invention can be expressed at one-celled plants cell (for example algae) or in the vegetable cell from higher plant (for example spermatophyte, such as crop).The example of plant expression vector comprises the expression vector that is specified in the following document: Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) " has the novel plant binary vector that is positioned at the contiguous selective marker of left margin ", Plant Mol.Biol.20:1195-1197; And Bevan, M.W. (1984) " the Agrobacterium binary vector that is used for Plant Transformation ", Nucl.Acid.Res.12:8711-8721, and comprise pLGV23, pGHlac+, pBIN19, pAK2004 and pDH51 (Pouwels etc. write (1985) Cloning Vectors.Elsevier:New YorkIBSN 0 444 904018).

In an embodiment again, nucleic acid of the present invention is expressed in mammalian cell with mammalian expression vector.The example of mammalian expression vector comprises pCDM8 (Seed, B. (1987) Nature 329:840) and pMT2PC (Kaufman etc. (1987) EMBO J.6:187-195).When being used for mammalian cell, the controlled function of described expression vector is provided by viral regulatory element usually.For example, Chang Yong promotor derives from polyomavirus, adenovirus 2, cytomegalovirus and simian virus 40.For being used for prokaryotic cell prokaryocyte and eukaryotic other appropriate expression system, referring to Sambrook, J., Fritsh, E.F. and Maniatis, the 16th and 17 chapters that T.Molecular Cloning:ALaboratory Manual. is the 2nd edition, Cold Spring HarborLaboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.

In another embodiment, the Mammals recombinant expression vector can instruct described nucleic acid preferentially to express (for example expressing described nucleic acid with the tissue specificity regulatory element) in specific cell type.The tissue specificity regulatory element is known in the art.The limiting examples of suitable tissue-specific promoter comprises white protein promotor (liver specificity; Pinkert etc. (1987) Genes Dev.1:268-277), promotor (Banerji etc. (1983) the Cell 33:729-740 of lymph (lymphoid) specificity promoter (Calame and Eaton (1988) Adv.Immunol.43:235-275), particularly promotor of TXi Baoshouti (Winoto and Baltimore (1989) EMBO J.8:729-733) and immunoglobulin (Ig); Queen and Baltimore (1983) Cell 33:741-748), neuronal specificity promotor (neurofilament promotor for example; Byrne and Ruddle (1989) PNAS86:5473-5477), pancreas specificity promoter (Edlund etc. (1985) Science 230:912-916) and mammary gland-specific promotor (whey promotor for example; U.S. Patent number 4,873,316 and European application publication No. 264,166).Also comprise and grow adjustment type promotor, for example muroid hox promotor (Kessel and Gruss (1990) Science 249:374-379) and afp promoter (Campes and Tilghman (1989) Genes Dev.3:537-546).

The present invention also provides and comprises the recombinant expression vector of being cloned into the dna molecular of the present invention in the expression vector with antisense orientation.That is described dna molecular with regulate sequence and be connected effectively, its mode of connection provides the expression (by transcribing described dna molecular) of the antisense rna molecule of HA mRNA.Can select effectively to be connected in antisense orientation clone's adjusting sequence nucleic acid, that instruct the described antisense rna molecule of continuous expression in the various kinds of cell type, for example viral promotors and/or enhanser, the adjusting sequence that perhaps can select to instruct composing type, tissue specificity or the cell type specificity of sense-rna to express.Antisense expression vector can be the form of recombinant plasmid, phagemid or attenuated virus, and wherein antisense nucleic acid produces under the control of efficient regulatory region, and its activity can be by the cell type decision that described carrier imported.For the discussion of the genetic expression adjusting of using inverted defined gene, referring to Weintraub, H. etc., as the sense-rna of genetic analysis molecular tool, Reviews-Trends in Genetics, the 1st (1) volume 1986.

Another aspect of the present invention relates to the host cell that imports recombinant expression vector of the present invention.Term " host cell " and " recombinant host cell " are used interchangeably in this article.Self-evident, this term is meant that not only specific topic states cell, and refers to the filial generation or the potential filial generation of this cell.Because in the successive generation because or sudden change or environmental influence and may have some modification, so this class filial generation in fact may be incomplete same with parental cell, but still be included in the term scope as herein described.

Host cell can be any prokaryotic cell prokaryocyte or eukaryotic cell.For example, HA albumen can for example be expressed in Corynebacterium glutamicum, insect cell, yeast cell or the mammalian cell (for example Chinese hamster ovary cell (CHO) or COS cell) at bacterial cell.Other proper host cell is well known by persons skilled in the art.Microorganism relevant with Corynebacterium glutamicum, that can be used as the host cell of nucleic acid of the present invention and protein molecular easily is shown in Table 3.

Can transform or rotaring dyeing technology by conventional, carrier DNA is imported in prokaryotic cell prokaryocyte or the eukaryotic cell.Term used herein " conversion " and " transfection ", " joint " and " transduction " is meant well known in the art with exogenous nucleic acid (for example being used for, linear DNA or RNA (for example linearized vector or DNAcarrier free independent gene construct)) or carrier format (plasmid for example, phage, phagemid (phasmid), phagemid (phagemid), transposon or other DNA) nucleic acid import the multiple technologies of host cell, comprise calcium phosphate or calcium chloride co-precipitation, the transfection of DEAE-dextran mediation, the fat transfection, natural competence, the transfer or the electroporation of chemical substance mediation.Be used to transform or the appropriate method of transfection host cell can be at (MolecularCloning:A Laboratory Manual. the 2nd edition such as Sambrook, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989) and in other experiment guide find.

About the stable transfection of mammalian cell, known to used expression vector and rotaring dyeing technology, only the sub-fraction cell can be incorporated into foreign DNA in its genome.In order to identify and select these integrons, the gene of the selective marker of will encoding usually (for example antibiotics resistance) imports in the host cell with interested gene.Preferred selective marker comprises gives medicine those selective markers of the resistance of G418, Totomycin and methotrexate for example.The nucleic acid of coding selective marker can be imported host cell on the proteic identical carrier of coding HA, perhaps it can be imported on independent carrier.Can identify (cell that has for example mixed selectable marker gene will be survived, and other necrocytosis) by for example medicament selection with importing nucleic acid stability cells transfected.

In order to produce the homologous recombination microorganism, preparation contains other have been introduced disappearance, added or has replaced to change the carrier of at least a portion HA gene of (for example functional destruction) described HA gene thus.Preferably, this HA gene is a Corynebacterium glutamicum HA gene, but it can be from Related Bacteria or even from the homologue in Mammals, yeast or insect source.In a preferred embodiment, design described carrier, make after homologous recombination, described endogenous HA gene is by functional destruction (i.e. encoding function albumen no longer; Be also referred to as " rejecting " carrier).Perhaps, can design described carrier, make after homologous recombination, described endogenous HA gene is suddenlyd change or is changed, but still encoding function albumen (for example can change the upstream regulation district, to change the proteic expression of described endogenous HA thus).In described homologous recombination vector, the reformed part of described HA gene is at the nucleic acid of its 5 ' end and the another kind of HA gene of 3 ' end adjacency, makes it possible between entrained external source HA gene of described carrier and the endogenous HA gene in the microorganism homologous recombination take place.Described another kind of flank HA nucleic acid has the length that is enough to native gene success homologous recombination.Usually, the flanking DNA (5 ' end and 3 ' end) (description of relevant homologous recombination vector, referring to for example Thomas, K.R. and Capecchi, M.R. (1987) Cell 51:503) that in described carrier, comprises thousands of bases.Described carrier is imported in the microorganism (for example passing through electroporation), then HA gene that is wherein imported with the choice of technology known in the art and the endogenous HA dna homolog cell of recombinating.

In another embodiment, can produce the recombinant microorganism that contains selecting system, described selecting system provides the expression of institute's quiding gene of being regulated.For example, be included in the HA gene that places under the control of lac operon on the carrier, allowing described HA gene only when IPTG exists, to express.This class regulation system is well-known in the art.

In another embodiment, destroy the endogenous HA gene (for example by homologous recombination or other genetic method known in the art) in the host cell, the feasible expression that its protein product does not take place.In another embodiment,, changed the endogenous or HA gene that imported in the host cell by one or more point mutation, disappearance or inversion, but its encoding function HA albumen still.In an embodiment again, changed one or more regulatory regions of HA gene in the microorganism (for example promotor, repressor or inductor) (for example by disappearance, brachymemma, inversion or point mutation), make and regulate described HA expression of gene.Those of skill in the art will recognize that the described HA gene and the protein modified host cell that contain more than one can adopt method of the present invention easily to produce, and mean and to be included in the present invention.

Host cell of the present invention (for example prokaryotic host cell in the culture or eukaryotic host cell) can be used for producing (promptly expressing) HA albumen.Therefore, the present invention also provides and uses host cell of the present invention to produce the proteic method of HA.In one embodiment, described method is included in the suitable medium cultivates host cell of the present invention and (has wherein imported the proteic recombinant expression vector of coding HA, or wherein genome has imported the proteic gene of HA encoding wild type or that change), until producing HA albumen.In another embodiment, described method also comprises separation HA albumen from substratum or from host cell.

C. isolated SMP proteins

Another aspect of the present invention relates to isolated SMP proteins and biologically-active moiety thereof." isolating " or " purifying " albumen or its biologically-active moiety are substantially free of cellular material when producing by recombinant DNA technology, or are substantially free of precursor or other chemical substance when chemosynthesis.Term " is substantially free of cellular material " and comprises the cellular component isolated SMP proteins prepared product that natural generation in wherein said protein and the cell or reorganization produce.In one embodiment, term " be substantially free of cellular material " and comprise have non-HA albumen (being also referred to as " contaminating protein " herein) be lower than about 30% (with dry weight basis), more preferably less than 20%, again more preferably less than about 10%, most preferably be lower than about 5% HA protein Preparation thing.When the reorganization of HA albumen or its biologically-active moiety produces, also preferably be substantially free of substratum, promptly substratum is lower than long-pending about 20% of described protein Preparation object, more preferably less than about 10%, most preferably is lower than about 5%.Term " is substantially free of precursor or other chemical substance " and comprises wherein HA albumen and the described albumen synthetic precursor of participation or other chemical substance isolated SMP proteins prepared product.In one embodiment, term " be substantially free of precursor or other chemical substance " and comprise the precursor that had or non-HA chemical substance be lower than about 30% (with dry weight basis), more preferably less than 20%, again more preferably less than about 10%, most preferably be lower than about 5% HA protein Preparation thing.In preferred embodiments, isolating protein or its biologically-active moiety are less than the contaminating protein of the same biology of being originated from described HA albumen.Usually, this proteinoid by microorganism for example in the Corynebacterium glutamicum recombinant expressed for example HOMEOSTASIS ADAPTATION PROTEIN produce.

Isolated SMP proteins of the present invention or its part can participate in swivel base, genetic expression (promptly transcribing or translation process), protein folding or the protein secreting of the reparation of DNA in the Corynebacterium glutamicum or reorganization, genetic material, or have one or more activity described in the table 1.In preferred embodiments, described protein or its part comprise and the enough homologous aminoacid sequences of a kind of aminoacid sequence of the present invention (for example a kind of even number SEQ ID NO sequence in the sequence table), make described protein or its part keep to participate in keeping the Corynebacterium glutamicum homeostasis or carry out the ability that participates in the function that this microorganism adapts to the varying environment condition.Described proteic described part biologically-active moiety preferably as herein described.In another preferred embodiment, HA albumen of the present invention has in the sequence table aminoacid sequence shown in the even number SEQ ID NO.In a preferred embodiment again, described HA albumen has the coded aminoacid sequence of nucleotide sequence with a kind of nucleotide sequence of the present invention (for example odd number SEQ ID NO sequence in the sequence table) hybridization (for example hybridize under stringent condition).In another preferred embodiment, described HA albumen has by following nucleotide sequence coded aminoacid sequence or its part, the homology of wherein said nucleotide sequence and a kind of nucleotide sequence of the present invention is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher.The present invention also comprises the scope and sign numerical value (for example 70-90% is identical or 80-95% identical) between the above-mentioned numerical value.For example, will comprise the ident value scope of above-mentioned value that adopt as any combination of the upper limit and/or lower limit.The preferred HA albumen of the present invention also preferably has at least a HA activity as herein described.For example, preferred HA albumen of the present invention comprise by with the nucleotide sequence coded aminoacid sequence of a kind of nucleotide sequence hybridization of the present invention, for example hybridize under stringent condition, and can participate in keeping the Corynebacterium glutamicum homeostasis and maybe can carry out this microorganism of participation, perhaps have one or more activity described in the table 1 function that the varying environment condition adapts to.

In other embodiments, described HA albumen and a kind of aminoacid sequence of the present invention (for example even number SEQ ID NO sequence in the sequence table) be homology basically, and the proteic functionally active that keeps one of aminoacid sequence of the present invention, but because natural variation or mutagenesis are different at aminoacid sequence, as describing in detail in the above I trifle.Therefore, in another embodiment, described HA albumen is a kind of like this protein, the amino sequence that described protein had and a kind of homology of complete amino acid sequence of the present invention are at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher, and have at least a HA activity as herein described.The present invention also comprises the scope and sign numerical value (for example 70-90% is identical or 80-95% identical) between the above-mentioned numerical value.For example, will comprise the ident value scope of above-mentioned value that adopt as any combination of the upper limit and/or lower limit.In another embodiment, the present invention relates to and a kind of complete amino acid sequence of the present invention Corynebacterium glutamicum albumen of homologous total length basically.

The proteic biologically-active moiety of HA comprise comprise derived from the aminoacid sequence of the proteic aminoacid sequence of HA (for example aminoacid sequence of even number SEQ ID NO in the sequence table) or with the peptide of the proteic aminoacid sequence of HA albumen homology, this comprises less than total length HA albumen or with the full length protein of HA albumen homology and show the amino acid of at least a HA protein-active.Usually, biologically-active moiety (peptide, for example length for example is 5,10,15,20,30,35,36,37,38,39,40,50,100 or more a plurality of amino acid whose peptide) comprises and has at least a HA proteic active structures territory or motif.In addition, other biologically-active moiety of wherein said proteinic other district's disappearance can prepare by recombinant technology, and estimates according to one or more activity as herein described.

Preferably, the proteic biologically-active moiety of HA comprises one or more selected structural domain/motifs or its part of biologically active.

HA albumen preferably produces by recombinant DNA technology.For example, the cloned nucleic acid molecule of code for said proteins in expression vector (as mentioned above), is imported host cell (as mentioned above) with described expression vector, in described host cell, express described HA albumen then.Can adopt standard protein purification technique by suitable purification scheme then, from described cell, isolate described HA albumen.As recombinant expressed alternative method, can use the standard peptide synthetic technology, chemosynthesis HA albumen, polypeptide or peptide.In addition, can for example adopt by standard technique, the anti-HA antibody that utilizes HA albumen of the present invention or its fragment to produce, separating natural HA albumen from cell (for example endotheliocyte).

The present invention also provides HA chimeric protein or fusion rotein.HA used herein " chimeric protein " or " fusion rotein " comprise the HA polypeptide that effectively is connected with non-HA polypeptide." HA polypeptide " is meant the polypeptide that has corresponding to the proteic aminoacid sequence of HA, and " non-HA polypeptide " be meant the aminoacid sequence that had corresponding to the described HA albumen proteinic polypeptide of homologous not basically, for example be different from described HA albumen and derive from same biology or different biological protein.In described fusion rotein, term " effectively connects " even is meant that described HA polypeptide and described non-HA polypeptide meet frame ground mutually and merge.Described non-HA polypeptide can merge N-terminal or the C-terminal to described HA polypeptide.For example, in one embodiment, described fusion rotein is that wherein the HA sequence merges to the GST-HA fusion rotein of the C-terminal of GST sequence.This class fusion rotein can be so that purification of Recombinant HA albumen.In another embodiment, described fusion rotein is the HA albumen that contains an allos signal sequence at its N-terminal.

In some host cell (for example mammalian host cell), can increase proteic expression of HA and/or secretion by utilizing the allos signal sequence.

Preferably, HA chimeric protein of the present invention or fusion rotein adopt the standard recombinant dna technology to produce.For example, according to routine techniques, for example by utilizing flush end or stagger end to connect, carry out Restriction Enzyme digestion so that suitable end to be provided, suitably mend flat sticky end, carry out alkaline phosphatase treatment to avoid undesirable connection, carry out enzyme then and connect, the dna fragmentation of the different peptide sequences of coding is linked together with meeting frame.In another embodiment,, comprise automatic dna synthesizer, can synthesize described fusion gene by routine techniques.Perhaps, adopt anchor primer to carry out the pcr amplification of gene fragment, described anchor primer produces complementary overhang between two consecutive gene fragments, subsequently with its annealing and amplification again, produce chimeric gene sequence (referring to for example Current Protocols in Molecular Biology, Ausubel etc. write, John Wiley ﹠amp; Sons; 1992).In addition, many expression vectors are commercially available, and encoded one merges part (for example gst polypeptide).The HA coding nucleic acid can be cloned in a kind of like this expression vector, make described fusion part meet frame ground and be connected with described HA albumen.

By described HA albumen is carried out mutagenesis, for example Li San point mutation or brachymemma can produce the proteic homologue of described HA.Term used herein " homologue " is meant the proteic variant form of described HA as described HA protein-active agonist or antagonist.The proteic agonist of described HA can keep the biological activity of a proteic identical biological activity of described HA or a subclass basically.The proteic antagonist of described HA is by for example combining with biological chemistry cascade downstream that comprises described HA albumen or upstream member competitively; or by being incorporated into the interactional with it target molecule of HA albumen; make functional interaction can not take place; or, can suppress proteic one or more activity of described HA of natural existence form by directly and HA protein binding and suppress its normal activity.

In an alternate embodiment, the proteic mutant of described HA that has HA protein agonist or an antagonistic activity by screening is the combinatorial library of truncated mutant for example, can identify the proteic homologue of described HA.In one embodiment, by carry out associating mutagenesis on the nucleic acid level, producing a piebald library (variegated library) of HA varient, is encoded by a piebald gene library in described piebald library.By for example enzyme process the synthetic oligonucleotide mixture is connected in the gene order, make one group of degeneracy potential HA sequence can be used as single expression of polypeptides, perhaps, can produce HA varient piebald library as the one group of bigger expressing fusion protein (for example being used for phage display) that wherein contains one group of HA sequence.There is several different methods can produce potential HA homologue library with the oligonucleotide sequence of cause degeneracy.Can in automatic dna synthesizer, carry out the chemosynthesis of degeneracy gene order, then described synthetic gene is connected in the suitable expression vector.Use one group of degeneracy gene, the feasible sequence that can in a kind of mixture, provide all to encode one group of required potential HA sequence.The method of synthetic degenerate oligonucleotide be known in the art (referring to for example Narang, S.A. (1983) Tetrahedron39:3; Itakura etc. (1984) Annu.Rev.Biochem.53:323; Itakura etc. (1984) Science 198:1056; Ike etc. (1983) Nucleic Acid Res.11:477).

In addition, the segmental library of described HA encoding histone can be used for producing the segmental piebald group of HA, is used for screening and select the proteic homologue of HA subsequently.In one embodiment, by handle the double-stranded PCR fragment of HA encoding sequence under the condition that a breach only takes place at each molecule with nuclease, make described double-stranded DNA sex change, with described DNA renaturation, can comprise the right double-stranded DNA of justice/antisense being arranged to form from different breach products, from the duplex that forms again, remove the strand part by handling, then the fragment library that is produced is connected in the expression vector, can produce an encoding sequence fragment library with the S1 nuclease.In this way, can obtain an expression library, the proteic N-terminal fragment of described HA, C-terminal fragment and the interior segments of described expression library coding all size.

Several technology known in the art is used to screen the gene product of the combinatorial library for preparing by point mutation or brachymemma and the cDNA library that screening has the gene product of selected characteristic.This class technology is applicable to that rapid screening passes through the gene library that combinatorial mutagenesis HA homologue produces.Be suitable for high throughput analysis, be used to screen the most widely used technology of big gene library, generally include described gene library is cloned in the rf expression vector, transform suitable cell with the vector library that is produced, and make described combination gene help to express under the isolating condition of carrier in required active detection, and the detected gene of its gene product of described vector encoded.The overall mutagenesis (REM) that circulates is a kind of new technology that improves functional type mutant frequency in the library, can be used in combination (Arkin and Yourvan (1992) PNAS89:7811-7815 with the screening assay of identifying the HA homologue; Delgrave etc. (1993) Protein Engineering 6 (3): 327-331).

In another embodiment, can adopt method well known in the art, use based on the mensuration of cell and analyze piebald HA library.

D. application of the present invention and method

Nucleic acid molecule as herein described, protein, protein homologs, fusion rotein, primer, carrier and host cell can be used for one or more following methods: the evaluation of Corynebacterium glutamicum and associated biomolecule; The genomic mapping of the biology relevant with Corynebacterium glutamicum; The evaluation and the location of interested Corynebacterium glutamicum sequence; Study on Evolution; The mensuration of the HA protein region that function is required; The adjusting of HA protein-active; The metabolic adjusting of one or more mineral compound; Adjusting to one or more aromatics or aliphatic cpd modification or degraded; The adjusting that the pair cell wall synthesizes or resets; To enzymic activity or proteoclastic adjusting; And cell produces the adjusting of required compound (for example fine chemicals).

HA nucleic acid molecule of the present invention serves many purposes.At first, they can be used for identifying the biology as Corynebacterium glutamicum or its closely related bacterial classification.In addition, they can be used for the existence of Corynebacterium glutamicum in the Identifying micro-organisms population mixture or its relevant bacterial classification.The invention provides the nucleotide sequence of many Corynebacterium glutamicum genes; By under stringent condition, using the probe of crossing over this biospecific Corynebacterium glutamicum gene zone, survey the genomic dna that is extracted of peculiar microbial population or mixing microorganisms colony culture, people can determine whether this biology exists.Though Corynebacterium glutamicum self is a non-virulent, for example corynebacterium diphtheriae is relevant with pathogenic species for it.The acute heat sexuality that corynebacterium diphtheriae is a kind of fast development, relate to part and systematic pathology dyes-pathogenic agent of diphtheria.In this disease, local patholoic change develops in the upper respiratory tract, comprises epithelial gangrenosum acne damage; Described bacillus excretes poison, and toxin permeates into the far-end susceptible tissue of body by this infringement.The degenerative change that is produced causes the systematic pathology of this disease by the protein synthesis in these tissues that suppress to comprise heart, muscle, peripheral nerve, suprarenal gland, kidney, liver and spleen.Diphtheria comprises that in many areas, the world sickness rate is very high always in the many independently states of Africa, Asia, European east and USSR (Union of Soviet Socialist Republics).Since nineteen ninety, caused at least 5,000 people's death in that latter two geographic diphtheria is popular.

In one embodiment, the invention provides the existence or the active method of corynebacterium diphtheriae in a kind of curee's of evaluation body.This method comprises and detects one or more nucleotide sequences of the present invention in curee's body or aminoacid sequence (for example being respectively the sequence shown in odd number in the sequence table or the even number SEQID NO), detects the existence or the activity of corynebacterium diphtheriae in described curee's body thus.Corynebacterium glutamicum and corynebacterium diphtheriae are Related Bacteria, and therefore many nucleic acid in the Corynebacterium glutamicum and protein molecule and corynebacterium diphtheriae nucleic acid and protein molecule homology can be used for detecting the intravital corynebacterium diphtheriae of curee.

Nucleic acid molecule of the present invention and protein molecule also can be as the marks of genome given zone.This not only can be applicable in the genomic mapping, also can be applicable to the proteic functional study of Corynebacterium glutamicum.For example, for the conjugated protein institute of specific Corynebacterium glutamicum DNA bonded zone in the identified gene group, can be with Corynebacterium glutamicum gene group digestion, then with described fragment with the conjugated protein incubation of described DNA.Can survey with nucleic acid molecule of the present invention in addition in conjunction with described proteic those zones, preferably survey with the mark that can detect easily; This nucleic acid molecule makes it possible to above-mentioned fragment is positioned on the Genome Atlas of Corynebacterium glutamicum with combining of described genomic fragment, and when carrying out repeatedly with different enzymes, helps the rapid determination of described albumen institute bonded nucleotide sequence.In addition, nucleic acid molecule of the present invention may have enough homologys with the sequence of relevant bacterial classification, so these nucleic acid molecule can be as the mark that for example makes up Genome Atlas in Related Bacteria in the brevibacterium.

HA nucleic acid molecule of the present invention also can be used for Study on Evolution and protein structure research.Relating to the process that adaptation that molecule of the present invention participates in and stable state keep is utilized by miscellaneous species; By the sequence of nucleic acid molecule of the present invention is compared to those sequences from the similar enzyme of coding of other biological, can estimate the evolution dependency of described biology.Equally, which district that described sequence is estimated in this relatively permission is conservative, does not guard in which district, and this helps to determine the necessary protein region of enzyme function.Research is valuable to such mensuration for protein engineering, and can provide protein and can tolerate and the index of not loss of function aspect mutagenesis.

Can cause producing to the operation of HA nucleic acid molecule of the present invention and be different from the proteic HA albumen of wild-type HA on the function.But these protein energy efficiency aspects or active aspect are improved, and the quantity that exists in cell may be greater than common quantity, but or energy efficiency or active the reduction.

The invention provides screening method, screening or by interacting with protein self or the proteic substrate of described HA or binding partners or transcribing or translate the molecule of regulating the HA protein-active by what regulate HA nucleic acid molecule of the present invention.In these class methods, the proteic microorganism of one or more HA of the present invention of expression is contacted with one or more test compounds, and estimate of the influence of every kind of test compound described HA protein-active or expression level.

The HA protein-active or the quantity that participate in cell walls biosynthesizing or rearrangement are regulated, may influence output, yield and/or the productive rate of one or more fine chemicals of Corynebacterium glutamicum cells produce.For example, by changing these activity of proteins, might regulate the structure or the thickness of cell walls.Cell walls mainly is used as the protective device of impermeabilisation cracking and external source damage; By modifying cell walls, might improve the Corynebacterium glutamicum opposing mechanical stress that this microorganism runs between large scale fermentation jar incubation period and the ability of shear-stress.In addition, each Corynebacterium glutamicum cell is centered on by thick cell walls, and therefore, sizable part of the biomass that exist in the large scale culturing thing is made up of cell walls.By improving the synthesis rate of cell walls, or synthesize (by HA cell wall protein of the present invention is carried out genetically engineered) by the active cells wall, described microbial growth speed might be improved.Equally, participate in the activity of proteins or the quantity of cell wall degradation by reduction, or, can reach the integral body increase that cell walls produces by reducing pair cell biosynthetic preventing of wall.The increase (this can finish by any above-mentioned proteinic change) of Corynebacterium glutamicum cell quantity alive, the cell quantity that should cause in the large scale fermentation jar culture producing required fine chemicals increases, and this yield or productive rate that should make these compounds of deriving from described culture produce improves.

To participate in modifying or the HOMEOSTASIS ADAPTATION PROTEIN activity or the quantity of degraded aromatics or aliphatic cpd are regulated, also can have direct or indirect influence to the generation of one or more fine chemicals of these cells.Some aromatics or aliphatic series are modified or degraded product is ideal fine chemicals (for example organic acid or modified aromatics and aliphatic cpd); Therefore, carry out the enzyme of these modifications (for example hydroxylation, methylate or isomerization) or DeR, might improve the yield of these required compounds by modification.Equally, participate in the further activity of proteins or the quantity of the approach of the modified or degradation production of the above-mentioned reaction of degraded, might improve the yield that derives from these fine chemicals of glutamic acid rod bacilli-cell in the culture by reducing.

These aromatics and aliphatic modifying enzyme and degrading enzyme itself are fine chemicals.These enzymes of purified form aromatics and aliphatic cpd (toxic chemical substance for example that can be used for degrading, petroleum products for example), perhaps be used to pollute on-the-spot bioreediation, the engineering that is used for refuse is decomposed, or be used for extensive and the economically feasible required modified aromatics or the production of aliphatic cpd or its degradation production, some above-mentioned substance can be easily as the carbon source of other fine chemicals production compound in the culture or the energy (referring to for example Feber, K. (1995) Biotransformations inOrganic Chemistry, Springer:Berlin and reference wherein; And Roberts, S.M. writes (1992-1996) Preparative Biotransformations, Wiley:Chichester and reference wherein).By these protein are carried out hereditary change, make other cell mechanism be alleviated or be eliminated their adjusting, might increase these proteinic total number or activity, not only improve the yield of these fine chemicals thus, and improve the activity of proteins of these results.

These aromatics and aliphatic modifying enzyme and degrading enzyme are modified, also can be had remote effect the generation of one or more fine chemicals.Many aromatics and aliphatic cpd (for example may as the impurity in the substratum or as those compounds that run into from the refuse of cellular metabolism) pair cell is toxic; By modifying and/or these compounds of degrading, make them easily to be removed or to destroy, should improve the viability of cell.In addition, these enzymes these compounds of can modifying or degrade, its modification or degraded mode make products therefrom can enter the normal carbon pathways metabolism of cell, therefore make cell can utilize these compounds carbon source or the energy as an alternative.Under the large scale culturing situation, when having the suitableeest carbon source of limited volume, these enzymes provide cell can utilize aromatics or aliphatic cpd as nutrient continued growth and splitted method.

In both cases, the Corynebacterium glutamicum cell quantity of producing required fine chemicals in the culture that is caused increases, and should and then cause the yield of described fine chemicals production or the raising of productive rate.

Modify participating in proteic activity of the metabolic HA of mineral compound or quantity, also can influence the production of one or more fine chemicals of Corynebacterium glutamicum or Related Bacteria culture directly or indirectly.For example, many ideal fine chemicals for example for example can not synthesize under the situation of phosphorus, nitrate, vitriol and iron at no inorganic molecule by nucleic acid, amino acid, cofactor and VITAMIN (for example VitB1, vitamin H and Thioctic Acid).Inorganic metabolism protein of the present invention makes cell to obtain these molecules from various mineral compound, and they are transferred in the various fine chemicals biosynthetic pathways.Therefore, by improving activity or the quantity that participates in the metabolic enzyme of these mineral compound, might increase the supply of these possible restricted inorganic molecules, directly raising contains this class through changing the output or the productive rate of the various fine chemicals of proteinic Corynebacterium glutamicum cells produce thus.Activity or quantity to the inorganic metabolic enzyme of the present invention are modified, also can be so that Corynebacterium glutamicum can utilize limited mineral compound supply better, or utilize the suitableeest non-mineral compound to come synthesizing amino acid, VITAMIN, cofactor or nucleic acid, all these is the cell continued growth and duplicates requisite.By improving the viability of these cells in the large scale culturing thing, also can increase the quantity of producing the Corynebacterium glutamicum cell of one or more fine chemicals in the culture, and then improve yield or productive rate that one or more fine chemicals are produced.

The Corynebacterium glutamicum enzyme of universal process itself is the ideal fine chemicals.The particular characteristics of enzyme (promptly comprising regiospecificity and stereospecificity) makes it become the useful catalyzer of external chemical reaction.Perhaps can be with the full cell of Corynebacterium glutamicum with suitable substrate incubation, make and in described cell, produce required product by enzyme, perhaps can make the Corynebacterium glutamicum culture required enzyme of (or culture of Related Bacteria) excessive generation and be purified, be used for the vitro reactions (perhaps be used for solution or be immobilized in suitable stationary phase) of industrial environment subsequently.In both cases, described enzyme can or natural Corynebacterium glutamicum protein, perhaps can be with its mutagenesis, to have the activity of change; The typical industrial application of this zymoid is included in the chemical industry as catalyzer (for example being used for synthetic organic chemistry), as foodstuff additive, feed ingredient, be used for processing fruits, process hides, washing agent, be used for analysis and medicine and be used for textile industry (referring to for example Yamada, H. (1993) " are used to produce the microbial reaction of useful organic compound ", Chimica 47:5-10; Roberts, S.M. (1998) " preparation property bio-transformation: enzyme and the full application of cell in synthetic chemistry ", J.Chem.Soc.PerkinTrans.1:157-169; Zaks, A. and Dodds, D.R. (1997) " applying biological catalysis and bio-transformation synthetic drugs ", DDT 2:513-531; Roberts, S.M. and Williamson, N.M. (1997) " application of enzyme in the analogue preparation of biologically active native product and optically active form ", Curr.Organ.Chemtstry 1:1-20; Faber, K. (1995) Biotransformationsin Organic Chemistry, Springer:Berlin; Roberts, S.M. write (1992-96) Preparative Biotransformations, Wiley:Chichester; Cheetham, P.S.J. (1995) " enzyme in the industry is used " is stated from: Handbook of Enzyme Biotechnology, the 3rd edition, Wiseman, A. writes, Elis:Horwood, 419-552 page or leaf; And Ullmann ' sEncyclopedia of Industrial Chemistry (1987) A9 volume, Enzymes, 390-457 page or leaf).Therefore, by activity or the quantity that improves these enzymes, might also improve cell is the ability of required product with the substrate conversion of being supplied, or possible these enzymes of excessive generation are to improve the yield in the large scale culturing thing.In addition, by these protein are carried out mutagenesis, might remove feedback inhibition or other prevents sexual cell to regulate control, make cell can produce and activate more substantial these enzymes, yield, output or the productive rate of these fine chemicals protein production that causes deriving from large scale culturing thus is higher.And, can change one or more Corynebacterium glutamicum pathways metabolisms, the activity of one or more fine chemicals biosynthesizing or excretory approach for example to the manipulation of these enzymes.

Proteolytic ferment of the present invention is carried out mutagenesis make them, also can influence yield, output and/or the productive rate that Corynebacterium glutamicum produces one or more fine chemicals directly or indirectly in active or change quantitatively.For example, by increasing these activity of proteins or quantity, might degrade owing to this cell is quick other that meets with during high-temperature, non-optimal pH and the fermentor cultivation thing coerced the proteinic ability increase of replying malfolding, and improve the viability of this bacterium in large scale culturing.The increase of cell quantity is owing to the cell quantity of producing one or more fine chemicals in the described culture is relatively large in these cultures, and the yield or the productive rate that therefore can cause these compounds to be produced improve.In addition, the Corynebacterium glutamicum cell has various kinds of cell surface protein enzyme, and they are used for external nutrient is decomposed into cell easily with its molecule that mixes as the nutrient of carbon source/energy or other kind.The activity of these enzymes or the increase of quantity can improve this turnover (turnover), and improve the level of available nutrient, improve cell growth or production thus.Therefore, to the modification of proteolytic enzyme of the present invention, can affect indirectly the fine chemicals production of Corynebacterium glutamicum.

When proteolytic enzyme of the present invention participates in the generation of required fine chemicals or degrades, can produce more directly influence to the fine chemicals production of modifying in response to one or more proteolytic enzyme of the present invention.By reducing degrade fine chemicals or the proteinic protease activities of degraded participation fine chemicals synthetic, might improve the level (increasing) of this fine chemicals because the degraded of described compound reduces or synthesizes.Equally, the protease activities raising that produces fine chemicals by degrading or produce the proteinic compound that participates in the fine chemicals degraded should reach similar result: deriving from the required fine chemicals level that contains these engineered proteinic Corynebacterium glutamicum cells increases.

Cause deriving from the above-mentioned HA albumen mutagenesis strategy that the fine chemicals yield of Corynebacterium glutamicum improves, and do not mean that it is restrictive; The variation of these strategies is conspicuous for those skilled in the art.Employ these tactics and add mechanism disclosed herein, can utilize nucleic acid molecule of the present invention and protein molecule to produce the Corynebacterium glutamicum or the Related Bacteria bacterial strain of expressing mutant HA nucleic acid molecule and protein molecule, make yield, output and/or the productive rate of required compound production be improved.This required compound can be the spawn that Corynebacterium glutamicum produces, and comprises the intermediate of the end product of biosynthetic pathway and naturally occurring pathways metabolism and is not molecule naturally occurring but that produced by Corynebacterium glutamicum strain of the present invention in the Corynebacterium glutamicum metabolism.

The present invention further specifies by following examples, and it is restrictive that described embodiment should not be construed as.The content of patent application, table and the sequence table of all reference of quoting in this application, patent application, patent, announcement is attached to herein by reference.

Table 1: the gene among the application

? Nucleic acid? SEQ?ID?NO	? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
							1 3 5 7	2 4 6 8	RXA02548 RXN00249 FRXA00249 RXA01073	GR00727 VV0057 GR00037 GR00300	3 36825 8837 1274	293 35869 7884 2104	Sulfuric acid adenylic acid (AMP) transferring enzyme subunit 2 (EC 2.7.7.4) adenylylsulfate kinase (EC 2.7.1.25) adenylylsulfate kinase (EC 2.7.1.25) NH (3) dependency NAD (+) synthetic enzyme (EC 6.3.5.1)
Urase
	? Nucleic acid? SEQ?ID?NO	? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
9 11 13 15 17 19 21 23 25 27 29								10 12 14 16 18 20 22 24 26 28 30	RXN02913 FRXA02264 RXN02274 FRXA02274 RXA02265 RXA02278 RXA02275 RXA02276 RXA02277 RXA02603 RXA01385	VV0020 GR00655 VV0020 GR00656 GR00655 GR00656 GR00656 GR00656 GR00656 GR00742 GR00406	8998 123 8509 3 452 3420 1632 2105 2802 7742 5320	8513 4 6800 1604 153 4268 2102 2782 3416 8737 3440	Urase β subunit (EC 3.5.1.5) urase α subunit (EC 3.5.1.5) urase α subunit (EC 3.5.1.5) urase α subunit (EC 3.5.1.5) urase γ subunit (EC 3.5.1.5) urase operon URED albumen urase accessory protein UREE urase accessory protein UREF urase is assisted albumen UREG 4-hydroxy-benzoic acid eight prenyltransferases (EC 2.5.1-) phenol 2 monooxygenases (EC 1.14.13.7)
	Proteolysis
? Nucleic acid? SEQ?ID?NO		? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
	31 33 35 37 39 41 43 45 47 49 51							32 34 36 38 40 42 44 46 48 50 52	RXN00675 FRXA00675 RXA01609 RXA01358 RXA01458 RXA01654 RXN01868 FRXA01868 FRXA01869 RXN03028 FRXA02470	VV0005 GR00178 GR00449 GR00393 GR00420 GR00459 VV0127 GR00534 GR00534 VV0008 GR00715	33258 2 2740 5337 3225 986 9980 1640 1954 41156 2216	34049 484 3612 6857 2176 1981 11905 30 1652 43930 3196	Alkaline serine protease [Much's bacillus] zinc metalloprotein enzyme (EC 3.4.24.-) zinc metalloprotein enzyme (EC 3.4.24-) zinc metalloprotein enzyme (EC 3.4.24.-) the ATP dependence CLP protease A TP binding subunit CLPA ATP dependence CLP protease A TP binding subunit CLPA that methionine aminopeptidase (EC 3.4.11.18) methionine aminopeptidase (EC 3.4.11.18) methionine aminopeptidase (EC 3.4.11.18) ATP dependence protein enzyme LA (EC 3.4.21.53) ATP dependence protein enzyme LA (EC 3.4.21.53) (AL022121) infers

Table 1 (continuing)

? Nucleic acid? SEQ?ID?NO	? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
							53 55 57 59 61 63 65 67 69 71 73 75 77 79 81 83 85 87 89 91 93 95 97 99 101 103 105 107 109 111 113 115 117 119 121 123 125 127 129 131	54 56 58 60 62 64 66 68 70 72 74 76 78 80 82 84 86 88 90 92 94 96 98 100 102 104 106 108 110 112 114 116 118 120 122 124 126 128 130 132	FRXA02471 RXA02630 RXA02834 RXA00112 RXA00566 RXA00567 RXN03094 FRXA01668 RXN01120 FRXA01120 RXA00744 RXA00844 RXA01151 RXA02317 RXA02644 RXN02820 FRXA02820 FRXA02000 RXN03178 FRXA02859 RXA00137 RXN00499 FRXA00499 RXN00877 FRXA00877 RXN01014 FRXA01014 FRXA01018 RXA01147 RXA01161 RXN01181 FRXA01181 RXN01277 FRXA01277 RXA01914 RXA02048 RXN00621 FRXA00621 RXN00622 FRXA00622	GR00715 GR00748 GR00823 GR00016 GR00152 GR00152 VV0057 GR00464 VV0182 GR00310 GR00202 GR00228 GR00324 GR00665 GR00751 VV0131 GR00801 GR00589 VV0334 GR10005 GR00022 VV0086 GR00125 VV0099 GR00242 VV0209 GR00289 GR00290 GR00323 GR00329 VV0065 GR00337 VV0009 GR00368 GR00548 GR00624 VV0135 GR00163 VV0135 GR00163	3159 2654 3 3687 742 1388 1794 2205 5678 2349 10722 3620 862 9664 767 4799 1 3430 921 846 738 8158 3 2221 3 13328 3 2289 1353 1253 1 1 32155 1738 125 207 5853 4075 5150 4778	4991 1332 497 2497 137 798 43 3920 4401 1072 9781 4453 5 9053 117 6109 507 3933 121 121 1826 9438 959 3885 1067 10728 1580 3152 94 117 957 957 34158 50 550 1580 5071 4857 3735 6193	ATPCLPATPCLPA ( AL021999 ) [] ATP,ATP DO ATPCLP ( EC 3.4.21.92 ) ATPCLP ( EC 3.4.21.92 ) CLPB CLPB ATPCLPATPCLPX ATPCLPATPCLPX ( EC 3.4.21.-) ATPZn E ( EC 3.4.-.-) Xaa-Pro ( EC 3.4.13.9 ) γ- ( EC 2.3.2.2 ) γ- ( EC 2.3.2.2 ) γ- ( EC 2.3.2.2 ) 5*Precursor (D-alanyl-D-alanine carboxypeptidase) (EC 3.4.16.4) penicillin-binding protein 5 * ( D--D- ) ( EC 3.4.16.4 ) Xaa-Pro ( EC 3.4.11.9 ) ( EC 3.4.11.5 ) DCP ( EC 3.4.15.5 ) DCP ( EC 3.4.15.5 ) N ( EC 3.4.11.2 ) N ( EC 3.4.11.2 ) N ( EC 3.4.11.2 ) I ( EC 3.4.11.1 ) Xaa-Pro ( EC 3.4.11.9 ) A/I ( Ec 3.411.1 ) ( EC 3.4.21.26 ) ( EC 3.4.21.26 ) N ( EC 3.4.11.2 ) II ( EC 3.4.21.83 ) PTRB II ( EC 3.4.21.83 ) PTRB

133 135 137 139 141

134 136 138 140 142

RXN00982 FRXA00977 FRXA00982 RXA00152 RXA02558

VV0149 GR00275 GR00276 GR00023 GR00731

7596 1647 5194 7175 4939

6091 2660 4949 5880 3965

(L42758) (L42758) (L42758) proteolytic enzyme [shallow Streptomyces glaucoviolaceus] HFLC albumen (EC 34.-.-) HFLC albumen (EC 3.4.-.-) of proteolytic enzyme [shallow Streptomyces glaucoviolaceus] of albumen alcohol [shallow Streptomyces glaucoviolaceus]

Table 1 (continuing)

? Nucleic acid? SEQ?ID?NO	? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
							143 145 147	144 146 148	RXA00500 RXA00501 RXA00502	GR00125 GR00125 GR00125	969 1643 2156	1643 2149 3187	O-sialoglycoprotein endopeptidase (EC 3.4.2457) O-sialoglycoprotein endopeptidase (EC 3.4.2457) O-sialoglycoprotein endopeptidase (EC 3.4.24.57)
General enzyme
	? Nucleic acid? SEQ?ID?NO	? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
149 151 153 155 157 159 161 163 165 167 169 171 173 175 177 179 181 183 185 187 189 191 193 195 197 199 201 203 205 207 209								150 152 154 156 158 160 162 164 166 168 170 172 174 176 178 180 182 184 186 188 190 192 194 196 198 200 202 204 206 208 210	RXN02589 FRXA02589 RXA00226 RXN01885 FRXA01885 RXA02592 RXN01795 FRXA01795 RXA01214 RXA01250 RXA02477 RXN00833 FRXA00833 RXA01224 RXA01182 RXA02531 RXN00689 FRXA00689 RXN03128 FRXA02192 RXA02351 RXN00905 FRXA00905 RXA00906 RXA00907 RXA02101 RXN02565 FRXA02565 FRXA02567 RXN03077 FRXA02855	VV0098 GR00741 GR00032 VV0184 GR00539 GR00741 VV0093 GR00507 GR00351 GR00364 GR00715 GR00225 GR00225 GR00354 GR00337 GR00726 VV0005 GR00180 VV0120 GR00643 GR00679 VV0238 GR00247 GR00247 GR00247 GR00631 VV0154 GR00733 GR00734 VV0043 GR10002	16346 13804 26836 2004 1589 18477 722 706 1640 592 10581 374 374 4186 1363 1226 22416 1401 3 2 132 8075 2 630 1143 3104 14299 1 3 1729 1693	17110 13040 26012 2804 2389 17707 1318 1140 3130 5 11201 6 6 5208 971 1936 20926 775 857 523 1070 8875 694 1133 1265 1842 13034 342 740 2913 2877	( EC 2.1.1.-) S- SAM ( EC 2.1.1.-) SAM SAM ( EC 2.1.1.73 ) ( EC 2.1.1.73 ) 1 ( EC 1.10.3.2 ) 1 ( EC 1.10.3.2 ) ( EC 4.2.1.1 ) ( EC 1.11.1-) ( EC 1.11.1-) 2- ( EC 1.13.11.32 ) - ( EC 1.2.1.8 ) - ( EC 1.2.1.8 ) 6- ( EC 1.1.1.218 ) 6- ( EC 1.1.1.218 ) A ( EC 1.14.13.-) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) N--L- ( EC 3.5.1.14 ) ,

211 213 215 217 219 221

212 214 216 218 220 222

RXA00026 RXA01971 RXA01802 RXN00866 FRXA00866 RXA02410

GR00003 GR00569 GR00509 VV0258 GR00236 GR00703

3657 963 3461 3557 3555 792

5042 133 4291 4522 4499 127

The Zn dependency lytic enzyme of the Zn dependency lytic enzyme prediction of the Zn dependency lytic enzyme prediction of lytic enzyme (HAD superfamily) prediction of the metal dependency lytic enzyme prediction of the hydroamidase of supposing (EC 3.5.1.-) supposition

Table 1 (continuing)

Nucleic acid SEQ?ID?NO	Amino acid SEQ?ID?NO	? The mark error code	? Contig	? NT is initial	? NT stops	? Function
							?223?225?227?229?231?233?235?237?239?241?243?245?247?249?251?253?255?257?259?261?263?265?267?269?271	?224?226?228?230?232?234?236?238?240?242?244?246?248?250?252?254?256?258?260?262?264?266?268?270?272	RXA00961 RXA00111 RXA01932 RXA02574 RXN00983 FRXA00983 RXA00984 RXN02513 FRXA02513 RXA00903 RXA01224 RXA01571 RXN02478 RXN00343 RXN01555 RXN01166 RXN02001 RXN03145 RXN01466 RXN01145 RXN03088 RXN02952 RXN00513 RXN01152 RXN00787	GR00267 GR00016 GR00555 GR00739 VV0231 GR00278 GR00278 VV0193 GR00722 GR00246 GR00354 GR00438 VV0119 VV0125 VV0135 VV0117 VV0326 VV0142 VV0019 VV0077 VV0052 VV0320 VV0092 VV0136 VV0321	2 930 6479 833 1796 1200 1716 737 93 637 4186 1360 7564 1118 29820 18142 630 7561 7050 7538 3431 1032 1573 1740 3736	433 1922 5583 1840 321 4 1300 6 824 5 5208 1959 6350 6 28861 16838 1787 7115 6091 6525 3817 1547 653 907 5637	( EC 1.14.13.1 ) ( SHE ) ( EC 3.3.2.3 ) ( EC 3.1.1.-) ( EC 3.2.1.18 ) ( EC 3.2.1.18 ) ( EC 3.2.1.18 ) ( EC 3.2.1.18 ) ( EC 3.2.1.18 ) 2- ( EC 1.13.11.32 ) ( EC 1.1.1.1 ) ( EC 3.2.1.18 ) 3-1- ( EC 1.3.99.4 ) 3-1- ( EC 1.3.99.4 ) ( EC 3.1.1.3 ) N--L- ( EC 3.5.1.14 ) 4- ( EC 5.3.2.-) ( EC 3.1.1.2 ) ( EC 1.1.1.86 ) ( EC 2.1.1-) - ( EC 2.7.8.23 ) -L-O- ( EC 2.1.1.77 ) D- ( EC 1.4.99.1 )
The N-metabolism
	Nucleic acid SEQ?ID?NO	Amino acid SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
?273?275?277?279?281?283?285?287?289								?274?276?278?280?282?284?286?288?290	RXN01302 FRXA01302 RXN01308 FRXA01307 FRXA01308 RXN01309 FRXA01309 RXA02017 RXA02018	VV0148 GR00376 VV0148 GR00377 GR00378 VV0158 GR00379 GR00610 GR00610	2837 370 2406 686 1211 1 719 1731 2788	2385 5 4 6 6 801 51 1048 1739	Nitrate reductase α chain (EC 1.7.99.4) nitrate reductase α chain (EC 1.7.99.4) nitrate reductase α chain (EC 1.7.99.4) nitrate reductase α chain (EC 1.7.99.4) nitrate reductase α chain (EC 1.7.99.4) nitrate reductase α chain (EC 1.7.99.4) nitrate reductase α chain (EC 1.7.99.4) nitrate reductase α chain (EC 1.7.99.4) nitrate reductase β chain (EC 1.7.99.4)

291 293 295 297

292 294 296 298

RXA02016 RXA00471 RXA00133 RXA00650

GR00610 GR00119 GR00021 GR00169

1036 2997 201 4017

260 3686 1013 3382

Nitrate reductase γ chain (EC 1.7.99.4) nitric acid/nitrous acid effect is regulated albumen NARL nitric acid/nitrous acid effect and is regulated albumen NARP nitric acid/nitrous acid effect adjusting albumen NARP

Table 1 (continuing)

? Nucleic acid? SEQ?ID?NO	Amino acid SEQ?ID?NO	Identification code	? Contig	? NT is initial	? NT stops	? Function
							299 301 303 305 307 309 311 313 315 317 319 321 323 325 327 329 331 333	?300?302?304?306?308?310?312?314?316?318?320?322?324?326?328?330?332?334	?RXA01189?RXA01607?RXN00470?FRXA00470?RXA00756?RXA00139?RXA01303?RXA01412?RXA00773?RXA02746?RXA02745?RXN00820?FRXA00820?RXA01059?RXN01386?RXN00073?RXN03131?RXS00153	GR00339 GR00449 VV0086 GR00119 GR00203 GR00022 GR00376 GR00412 GR00205 GR00764 GR00763 VV0054 GR00221 GR00296 VV0008 VV0154 VV0127 VV0167	2545 123 27401 1752 2932 2514 1724 620 3208 1 15350 19455 1007 8782 39246 2369 276 4195	1937 752 28669 2951 1937 3224 390 417 4350 267 14472 19817 1369 9390 38317 687 4 4620	Nitric acid/nitrous acid effect adjusting albumen NARP nitric acid/nitrous acid effect adjusting albumen NARP nitric acid/nitrous acid induction albumen NARX (EC 2.7.3.-) nitric acid/nitrous acid induction albumen NARX (EC 2.7.3.-) N utilizes material albumin A N to utilize material protein B nitrous acid to extrude albumen fixed nitrogen albumen FIXI (possible E1-E2 type cation A TP enzyme) (EC 3.6.1.-) nitrogen and regulates albumen NIFR3 nitrogen adjusting albumen P-II dross ATP in conjunction with protein I nodulation protein N nodulation protein N oxygen insensitivity NAD (P) H nitrate reductase (EC 1.-.-.-) nitrilase adjusting albumen ferredoxin-nitrite reductase (EC 1.7.7.1) rhizopin catabolic protein MOCC nodulation protein
? Urase
	? Nucleic acid? SEQ?ID?NO	Amino acid SEQ?ID?NO	Identification code	? Contig	? NT is initial	? NT stops	? Function
Phosphoric acid and phosphonate metabolizing
	? Nucleic acid? SEQ?ID?NO	Amino acid SEQ?ID?NO	Identification code	? Contig	? NT is initial	? NT stops	? Function
335 337 339 341 343								?336?338?340?342?344	?RXN01716?RXN02972?RXN00663?RXN00778?RXN00250	?VV0319?VV0319?VV0142?VV0103?VV0189	?3259?2763?10120?18126?286	?2774?2353?11493?19250?1032	Polyphosphoric acid excision enzyme (EC 3.6.1.11) polyphosphoric acid excision enzyme (EC 3.6.1.11) PHOH albumen homologue phosphoric acid in conjunction with periplasm protein precursor DEDA albumen-alkaline phosphatase sample albumen
	Sulfo-is thanked
? Nucleic acid? SEQ?ID?NO		Amino acid SEQ?ID?NO	Identification code	Contig	NT is initial	NT stops	? Function

345 347 349

346 348 350

RXA00072 RXA00793 RXA01192

GR00012 GR00211 GR00342

446 1469 161

6 2644 733

The hungry inducible protein 6 of hungry inducible protein 6 sulfuric acid of adenosine phosphate-phosphinylidyne sulfate reduction enzyme (EC 1.8.99.4) sulfuric acid

Table 1 (continuing)

? Nucleic acid? SEQ?ID?NO	? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
							351 353 355 357	352 354 356 358	RXA00715 RXA01664 RXN02334 FRXA02334	GR00188 GR00463 VV0141 GR00672	2120 1306 7939 2	2914 485 7217 355	Thiosulfate transsulfurase (EC 2.8.1.1) thiosulfate transsulfurase (EC 2.8.1.1) thiosulfate transsulfurase (EC 2.8.1.1) thiosulfate transsulfurase (EC 2.8.1.1)
The Fe-metabolism
	? Nucleic acid? SEQ?ID?NO	? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
359 361								360 362	RXN01499 RXN01997	VV0008 VV0084	7034 33308	3213 33793	Enterobactin synthetic enzyme component F ferritin
	The Mg metabolism
? Nucleic acid? SEQ?ID?NO		? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
	363 365 367 369 371							364 366 368 370 372	RXA01848 RXN01849 FRXA01849 FRXA01691 RXN00665	GR00524 VV0139 GR00524 GR00474 VV0252	1532 16415 2004 570 135	789 17515 1555 4 635	Magnesium-chelatase subunit CHLI magnesium-chelatase subunit CHLI magnesium-chelatase subunit CHLI magnesium-chelatase subunit CHLI Mg2+/secondary the translocator of citric acid complex body (secondary transporter)
The modification of aromatic substance and degraded
	? Nucleic acid? SEQ?ID?NO	? Amino acid? SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
373 375 377 379 381 383 385 387 389 391 393 395								374 376 378 380 382 384 386 388 390 392 394 396	RXN03026 RXN02908 RXN03000 RXN03036 RXN02974 RXN00393 RXN00948 RXN01923 RXN00398 RXN02813 RXN00136 RXN02508	VV0007 VV0025 VV0235 VV0014 VV0229 VV0025 VV0107 VV0020 VV0025 VV0128 VV0134 VV0007	28635 8507 570 671 12631 7241 4266 3384 14633 13120 13373 26733	28901 8247 4 6 12437 6348 5384 4133 13884 14118 14467 28586	3-dehydroquinate dehydratase (EC 4.2.1.10) O-succinyl-phenylformic acid-CoA ligase enzyme (EC 6.2.1.26) salicylate hydroxylase (EC 1.14.13.1) Protocatechuic Acid 3,4-dioxygenase β chain (EC 1.13.11.3) 4-nitrophenyl Phosphoric acid esterase (EC 3.1.3.41) 1,4-dihydroxyl-2-naphthoic acid eight prenyltransferases (EC 2.5.-.-) 12-oxygen phytadiene acid (oxophytodienoate) reductase enzyme (EC 1.3.1.42) 2-hydroxyl-6-oxygen-6-phenyl own-2,4-diolefinic acid lytic enzyme (EC 3.7.1.-) 2-pyrone-4,6-dicarboxylic acid lactonase (EC 3.1.1.57) 3-carboxyl-cis, cis-muconate cycloisomerase homologue (EC 5.5.1.2) 3-Dehydroquinate synthase (EC 4.6.1.3) 3-dehydrogenation shikimic acid dehydratase (EC 4.2.1.-)

397 399 401 403 405 407

398 400 402 404 406 408

RXN02839 RXN00639 RXN02530 RXN00434 RXN01619 RXN01842

VV0362 VV0128 VV0057 VV0112 VV0050 VV0234

3 7858 5469 12078 24649 1615

449 8712 6125 11212 23675 2532

4-hydroxy-benzoic acid eight prenyltransferases (EC 2.5.1.-) catechol 1,2-dioxygenase (EC 1.13.11.1) dimethylaniline monooxygenase (formation of N-oxide compound) 1 (EC 1.14.13.8) quinone oxidoreductase (EC 1.6.5.5) quinone oxidoreductase (EC 1.6.5.5) quinone oxidoreductase (EC 1.6.5.5)

Table 1 (continuing)

? Nucleic acid? SEQ?ID?NO	Amino acid SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NTX stops	? Function
							409 411 413 415 417 419 421 423 425	?410?412?414?416?418?420?422?424?426	RXN00641 RXN01993 RXN00658 RXN00178 RXN01461 RXN01653 RXN02053 RXN00177 RXC00963	VV0128 VV0182 VV0083 VV0174 VV0128 VV0321 VV0009 VV0174 VV0249	7440 16 15705 14670 12414 12867 39448 13589 1816	5950 1143 16397 15554 13025 11407 40026 14656 2652	Toluic acid 1,2-dioxygenase α subunit (EC 1.14.12-) vanillic acid demethylase (EC 1.14.-.-) phenol 2-monooxygenase (EC 1.14.13.7) hydroxyquinol 1,2-dioxygenase (EC 1.13.11.37) Protocatechuic Acid 3,4-dioxygenase α chain (EC 1.13.11.3) dibenzothiophene desulphurase A DRGA albumen maleoyl acetate reductase enzyme (EC 1.3.1.32) participates in the protein of aromatic substance degraded
The modification of aliphatic cpd and degraded
	? Nucleic acid? SEQ?ID?NO	Amino acid SEQ?ID?NO	? Identification code	? Contig	? NT is initial	? NT stops	? Function
427 429 431 433 435 437 439								?428?430?432?434?436?438?440	RXN00299 FRXA00299 RXN00332 RXA01838 RXA02643 RXA01933 RXA02351	VV0176 GR00048 GR00057 GR00519 GR00750 GR00555 GR00679	43379 7376 16086 2 1603 6590 132	42402 6633 15385 820 560 7192 1070	Alkanal monooxygenase α chain (EC 1.14.14.3) alkanal monooxygenase α chain (EC 1.14.14.3) alkanal monooxygenase α chain (EC 1.14.14.3) alkanal monooxygenase α chain (EC 1.14.14.3) alkanal monooxygenase α chain (EC 1.14.14.3) 2-halogenated-chain acid dehalogenase I (EC 3.8.1.2) nitrilotriacetic acid(NTA) monooxygenase component A (EC 1.14.13.-)

The gene that table 2-gets rid of
	GenBank TMRegistration number	The gene title	Gene function	Reference
A09073					ppg	Phosphoenolpyruvate carboxylase	Bachmann, B. etc. " dna fragmentation of coding Phosphoenolpyruvate carboxylase, carry described segmental recombinant DNA, have the bacterial strain of described recombinant DNA and adopt described bacterial strain to produce the amino acid whose method of L-", patent: EP 0358940-A 3 03/21/90
	A45579， A45581， A45583， A45585 A45587		Threonine dehydra(ta)se	Moeckel, B. etc. " utilization has the recombinant microorganism of regulating threonine dehydra(ta)se and produces the L-Isoleucine " patent: WO 9519442-A 5 07/20/95
AB003132					murC；ftsQ；fisZ		Kobayashi, M. etc. " from clone, order-checking and the characterized of the ftsZ gene of bar shaped bacteria " Biochem.Biophys.Res.Commun., 236 (2): 383-388 (1997)
	AB015023	murC；ftsQ		Wachi, M. etc. " from the murC gene of excellent bacillus " Appl.Microbiol.Biotechnol, 51 (2): 223-228 (1999)
AB018530					dtsR		Kimura, E. etc. " rescue is derived from the molecular cloning of the novel gene dtsR of the mutant washing agent susceptibility of brevibacterium ", Biosci.Biotechnol.Biochem., 60 (10): 1565-1570 (1996)
	AB018531	dtsR1；dtsR2
AB020624					murI	The D-glutamate racemase
	AB023377	tkt	Transketolase
AB024708					gltB；gltD	Big subunit of glutamine 2-oxoglutaric acid transaminase and small subunit
	AB025424	acn	Along the achilleic acid enzyme
AB027714					rep	Replication protein
	AB027715	rep；aad	Replication protein; Aminoglycoside adenylic acid (AMP) transferring enzyme
AF005242					argC	N-acetylglutamat-5-semialdehyde desaturase
	AF005635	glnA	Glutamine synthetase
AF030405					hisF	Cyclase
	AF030520	argG	Argininosuccinate synthetase
AF031518					argF	Ornithine transcarbamylase
	AF036932	aroD	The 3-dehydroquinate dehydratase
AF038548					pyc	Pyruvate carboxylase

Table 2 (continuing)
	AF038651	dciAE；apt；rel	Two peptide-binding proteins; Adenine phosphoribosyltransferase; The GTP pyrophosphokinase	Wehmeier, L. etc. " effect of Corynebacterium glutamicum rel gene in (p) ppGpp metabolism ", Microbiology, 144:1853-1862 (1998)
AF041436					argR	The arginine repressor
	AF045998	impA	The inositol monophosphate Phosphoric acid esterase
AF048764					argH	The argininosuccinic acid lyase
	AF049897	argC；argJ；argB； argD；argF；argR argG；argH	N-acetyl glutamy phosphoric acid reduction enzyme; The ornithine acetyltransferase; The N-acetylglutamat kinases; Acetyl-ornithine transaminase; Ornithine carbamyl transferase; The arginine repressor; The argininosuccinic acid synthase; The argininosuccinic acid lyase
AF050109					inhA	Alkene acyl-acyl carrier protein reductase enzyme
	AF050166	hisG	The ATP phosphoribosyltransferase
AF051846					hisA	Formyl imino--5-amino-ribose 1-phosphate base-4-Imidazole carboxamide Nucleotide isomerase
	AF052652	metA	Homoserine O-acetyltransferase	Park, S. etc. " separation and the analysis of the methionine(Met) biosynthesis gene of coding homoserine acetyltransferase in metA-Corynebacterium glutamicum ", Mol.Cells., 8 (3): 286-294 (1998)
AF053071					aroB	The dehydroquinic acid synthetic enzyme
	AF060558	hisH	The glutamine transamidase
AF086704					hisE	Phosphoribosyl-ATP-pyrophosphohydrolase
	AF114233	aroA	5-enol pyruvic acid shikimic acid 3-phosphate synthase
AF116184					panD	L-aspartic acid-α-decarboxylase precursor	Dusch, N. etc. " the Corynebacterium glutamicum panD expression of gene of coding L-aspartic acid-α-decarboxylase causes excessive generation pantothenic acid in intestinal bacteria ", Appl.Environ.Microbiol, 65 (4) 1530-1539 (1999)
	AF124518	aroD；aroE	3-dehydroquinase (dehydroquinase); Shikimate dehydrogenase
AF124600					aroC；aroK；aroB； pepQ	Chorismate synthase; Shikimate kinase; 3-Dehydroquinate synthase; The kytoplasm peptase of inferring
	AF145897	inhA
AF145898					inhA

Table 2 (continuing)
	AJ001436	?ectP	The transhipment of ectoine, trimethyl-glycine, proline(Pro)	Peter, H. etc. " Corynebacterium glutamicum has second carrier of four kinds of coupling solutes: evaluation, order-checking and the characterized of proline(Pro)/ectoine shooting system Prop and ectoine/ proline(Pro)/trimethyl-glycine carrier EctP ", J. Bacteriol., 180 (22): 6005-6012 (1998)
AJ004934					?dapD	Tetrahydrochysene 2, dipicolimic acid 2 succinylation enzyme is (incomplete i)	Wehrmann, A etc. " diaminopimelic acid synthetic patterns of differences and the effect aspect the cell walls integrity thereof: ", J.Bacteriol., 180 (12): 3159-3165 (1998) with the research of Corynebacterium glutamicum
	AJ007732	?ppc；secG；amt；ocd；?soxA	Phosphoenolpyruvate carboxylase; The high affinity ammonium is taken in albumen; The ornithine of inferring-ring decarboxylase; Sarcosine oxidase
AJ010319					?flsY，glnB，glnD；srp；?amtP	Participate in cell fission; PII albumen; Uridyl transferase (uridine acyl group removing enzyme); Signal recognition particle; Low affinity ammonium is taken in albumen	Jakoby, M. etc. " regulate by the nitrogen in the Corynebacterium glutamicum; Relate to the separation of the biological chemistry genes identified of respective egg white matter ", FEMS Microbiol., 173 (2); 303-310 (1999)
	AJ132968	?cat	Chloramphenicol acetyltransferase
AJ224946					?mqo	L MALIC ACID; Quinone oxidoreductase	Molenaar, D. etc. " derive from the biological chemistry and the genetics characterized of the relevant malate dehydrogenase (malic acid dehydrogenase) (acceptor) of film of Corynebacterium glutamicum ", Eur.J.Biochem., 254 (2): 395-403 (1998)
	AJ238250	?ndh	Nadh dehydrogenase
AJ238703					?porA	Porin	Lichtinger, T. etc. " biological chemistry of Corynebacterium glutamicum cell envelope porin and biophysics characterized: this passage is formed by low molecular weight polypeptide ", Biochemistry, 37 (43): 15024-15032 (1998)
	D17429		Transposable element IS31831	Vertes etc. " derive from separation and the characterized of the transposable element IS31831 of Corynebacterium glutamicum ", Mol. Microbiol., 11 (4): 739-746 (1994)
D84102					?odhA	The 2-oxoglutaric acid desaturase	Usuda, Y. etc. " molecular cloning of the Corynebacterium glutamicum of encoding novel 2-oxoglutaric acid desaturase (brevibacterium AJ12036) odhA gene ", Microbiology, 142:3347-3354 (1996)
	E01358	?hdh；hk	Homoserine dehydrogenase; Homoserine kinase	Katsumata, R. etc. " production of L-Threonine and L-Isoleucine ", patent: JP 1987232392-A 1 10/12/87
E01359						Homoserine kinase gene start codon upstream	Katsumata, R. etc. " production of L-Threonine and L-Isoleucine ", patent: JP 1987232392-A 2 10/12/87
	E01375		Tryptophan operon
E01376					?trpL；trpE	Leading peptide; The o-amino benzoyl acid synthase	Matsui, K. etc. " tryptophan operon, by peptide and protein, the utilization of tryptophan operon genetic expression and the production of tryptophane of its coding ", patent: JP 1987244382-A 1 10/24/87

Table 2 (continuing)
	E01377		The promotor of tryptophan operon and operator region	Matsui, K. etc. " tryptophan operon, by peptide and protein, the utilization of tryptophan operon genetic expression and the production of tryptophane of its coding ", patent: JP 1987244382-A 1 10/24/87
E03937						The vitamin H synthase	Hatakeyama, K. etc. the dna fragmentation and the application thereof of gene of plain synthetic enzyme " contain can encoding human ", patent: JP 1992278088-A 1 10/02/92
	E04040		Diamino pelargonic amino transferase	Kohama, K. etc. " gene and the application thereof of coding diamino pelargonic amino transferase and dethiobiotin synthetase ", patent: JP 1992330284-A 1 11/18/92
E04041						Dethiobiotin synthetase	Kohama, K. etc. " gene and the application thereof of coding diamino pelargonic amino transferase and dethiobiotin synthetase ", patent: JP 1992330284-A 1 11/18/92
	E04307		The Flavum L-Aspartase	Kurusu, Y. etc. " gene DNA and the application thereof of coding L-Aspartase ", patent: JP 1993030977-A 1 02/09/93
E04376						Isocitrate lyase	Katsumata, R. etc. " gene shows controlled DNA ", patent: JP 1993056782-A 3 03/09/93
	E04377		Isocitrate lyase N-terminal fragment	Katsumata, R. etc. " gene shows controlled DNA ", patent: JP 1993056782-A 3 03/09/93
E04484						Prephenate dehydratase	Sotouchi, N. etc. " by fermentative production L-phenylalanine ", patent: JP 1993076352-A 2 03/30/97
	E05108		E.C. 2.7.2.4.	Fugono, N. etc. " gene DNA and the application thereof of coding E.C. 2.7.2.4. ", patent: JP 1993184366-A 1 07/27/93
E05112						Dihydro-dipichorinate synthetic enzyme	Hatakeyama, K. etc. " coding dihydro 2, the gene DNA of dipicolimic acid 2 synthetic enzyme and application thereof ", patent: JP 1993184371-A 1 07/27/93
	E05776		Diaminopimelate dehydrogenase	Kobayashi, M. etc. " gene DNA and the application thereof of coding diaminopimelate dehydrogenase ", patent: JP 1993284970-A 1 11/02/93
E05779						Threonine synthase	Kohama, K. etc. " gene DNA and the application thereof of coding threonine synthase ", patent: JP 1993284972-A 1 11/02/93
	E06110		Prephenate dehydratase	Kikuchi, T. etc. " by fermentative Production L-phenylalanine ", patent: JP 1993344881-A 1 12/27/93
E06111						The mutant prephenate dehydratase	Kikuchi, T. etc. " by fermentative Production L-phenylalanine ", patent: JP 1993344881-A 1 12/27/93
	E06146		Acetohydroxy acid synthetase	Inui, M. etc. " gene and the application thereof of the acetohydroxy acid synthetase of can encoding ", patent: JP 1993344893-A 1 12/27/93
E06825						E.C. 2.7.2.4.	Sugimoto, M. etc. " mutant aspartokinase gene ", patent: JP 1994062866-A 1 03/08/94
	E06826		Mutant E.C. 2.7.2.4. α subunit	Sugimoto, M. etc. " mutant aspartokinase gene ", patent: JP 1994062866-A 1

			03/08/94

Table 2 (continuing)
	E06827		Mutant E.C. 2.7.2.4. α subunit	Sugimoto, M. etc. " mutant aspartokinase gene ", patent: JP 1994062866-A 1 03/08/94
E07701					secY		Honno, N. etc. " participate in the gene DNA that membranin and film are integrated ", patent: JP 1994169780-A 1 06/21/94
	E08177		E.C. 2.7.2.4.	Sato, Y. etc. " gene DNA and the application thereof of the E.C. 2.7.2.4. that discharges from feedback inhibition of can encoding ", patent: JP 1994261766-A 1 09/20/94
E08178， E08179， E08180， E08181， E08182						The E.C. 2.7.2.4. that feedback inhibition discharges	Sato, Y. etc. " gene DNA and the application thereof of the E.C. 2.7.2.4. that discharges from feedback inhibition of can encoding ", patent: JP 1994261766-A 1 09/20/94
	E08232		Acetohydroxy acid isomeroreductase	Inui, M. etc. " gene DNA of coding acetohydroxy acid isomeroreductase ", patent: JP 1994277067-A 1 10/04/94
E08234					secE		Asai, Y. etc. " gene DNA of coded protein transhipment machine ", patent: JP 1994277073-A 1 10/04/94
	E08643		FT transaminase and dethiobiotin synthetase promoter region	Hatakeyama, K. etc. " dna fragmentation that has promoter function in the bar shaped bacteria ", patent: JP 1995031476-A 1 02/03/95
E08646						The vitamin H synthetic enzyme	Hatakeyama, K. etc. " dna fragmentation that has promoter function in the bar shaped bacteria ", patent: JP 1995031476-A 1 02/03/95
	E08649		L-Aspartase	Kohama, K. etc. " dna fragmentation that has promoter function in the bar shaped bacteria ", patent: JP 1995031478-A 1 02/03/95
E08900						Dihydro 2, the dipicolimic acid 2 reductase enzyme	Madori, M. etc. " contain coding dihydro 2, the dna fragmentation of the gene of dipicolimic acid 2 reductase enzyme and application thereof ", patent: JP 1995075578-A 1 03/20/95
	E08901		Diaminapimelate decarboxylase	Madori, M. etc. " contain the dna fragmentation and the application thereof of the gene of the diaminapimelate decarboxylase of encoding ", patent: JP 1995075579-A 1 03/20/95
E12594						Serine hydroxymethylase	Hatakeyama, K. etc. " production of L-tryptophane ", patent: JP 1997028391-A 1 02/04/97
	E12760， E12759， E12758		Transposase	Moriya, M etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97
E12764						Arginyl-tRNA synthetase; Diaminapimelate decarboxylase	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97
	E12767		Dihydro 2, the dipicolimic acid 2 synthetic enzyme	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97

Table 2 (continuing)
	E12770		E.C. 2.7.2.4.	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97
E12773						Dihydro 2, the dipicolimic acid 2 reductase enzyme	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97
	E13655		Glucose-6-phosphate dehydrogenase (G6PD)	Hatakeyama, K. etc. " glucose-6-phosphate dehydrogenase (G6PD) and its DNA of can encoding ", patent: JP 1997224661-A 1 09/02/97
L01508					IlvA	Threonine dehydra(ta)se	Moeckel, B. etc. " function of Corynebacterium glutamicum threonine dehydra(ta)se and structural analysis ", J.Bacteriol., 174:8065-8072 (1992)
	L07603	EC?4.2.1.15	The Arabic heptanone saccharic acid of 3-deoxidation-D--7-phosphate synthase	Chen, C. etc. " clone and the nucleotide sequence of the Arabic heptanone saccharic acid of Corynebacterium glutamicum 3-deoxidation-D--7-unicorn acid synthase gene ", FEMS Microbiol.Lett., 107:223-230 (1993)
L09232					IlvB；ilvN；ilvC	The big subunit of acetohydroxy acid synthase; The acetohydroxy acid synthase small subunit; Acetohydroxy acid isomeroreductase	Keilhauer, C. etc. " Isoleucine in the Corynebacterium glutamicum is synthetic: the analysis of molecules of ilvB-ilvN-ilvC operon ", J.Bacteriol, 175 (17): 5595-5603 (1993)
	L18874	PtsM	The phosphoenolpyruvic acid sugar phosphotransferase	Fouet, A etc. " the sucrose specific enzymes II of Bacillus subtilus phosphotransferase system: the expression in intestinal bacteria and with homology from the enzyme II of enterobacteria ", PNAS USA, 84 (24): 8773-8777 (1987); Lee, J.K. etc. " analysis of the nucleotide sequence of the gene of coding Corynebacterium glutamicum seminase II and the protein sequence of derivation ", FEMS Microbiol.Lett., 119 (1-2): 137-145 (1994)
L27123					aceB	Malate synthase	Lee, H-S. etc. " characterization of molecules of the gene of coding malate synthase is identified in aceB-Corynebacterium glutamicum ", J.Microbiol.Biotechnol., 4 (4): 256-263 (1994)
	L27126		Pyruvate kinase	Jetten, M.S. etc. " from the structure and the functional analysis of the pyruvate kinase of Corynebacterium glutamicum ", Appl. Environ.Microbiol., 60 (7): 2501-2507 (1994)
L28760					aceA	Isocitrate lyase
	L35906	dtxr	The diphtheria toxin repressor	Oguiza, J.A. etc. " from molecular cloning, dna sequence analysis and the characterized of the corynebacterium diphtheriae dtxR of brevibacterium ", J.Bacteriol., 177 (2): 465-467 (1995)
M13774						Prephenate dehydratase	Follettie, M.T. etc. " molecular cloning and the nucleotide sequence of Corynebacterium glutamicum pheA gene ", J. Bacteriol., 167:695-702 (1986)
	M16175	5S?rRNA		Park, Y-H. etc. " analyze the kind system that bar shaped bacteria carries out by 56 kinds of rRNA sequences ", J. Bacteriol., 169:1801-1806 (1987)
M16663					trpE	The o-amino benzoyl acid synthase, 5 ' end	Sano, K. etc. " a kind of L-glutamic acid is produced the 26S Proteasome Structure and Function of bacterium-brevibacterium trp operon control region ", Gene, 52:191-200 (1987)
	M16664	trpA	Tryptophan synthetase, 3 ' end	Sano, K. etc. " a kind of L-glutamic acid is produced the 26S Proteasome Structure and Function of bacterium-brevibacterium trp operon control region ", Gene, 52:191-200 (1987)

Table 2 (continuing)
	M25819		Phosphoenolpyruvate carboxylase	O ' Regan, M. etc. " clone and the nucleotide sequence of the Phosphoenolpyruvate carboxylase encoding gene of Corynebacterium glutamicum ATCC13032 ", Gene, 77 (2): 237-251 (1989)
M85106						23S rRNA gene insertion sequence	Roller, C. etc. " intragenic one of its 23SrRNA that is characterized as with gram positive bacterium of high DNA G+C content inserts jointly ", J.Gen.Microbiol., 138:1167-1175 (1992)
	M85107， M85108		23S rRNA gene insertion sequence	Roller, C. etc. " intragenic one of its 23SrRNA that is characterized as with gram positive bacterium of high DNA G+C content inserts jointly ", J.Gen.Microbiol., 138:1167-1175 (1992)
M89931					aecD；brnQ；yhbw	β C-S lyase; Branched-chain amino acid is taken in carrier; The albumen yhbw that supposes	Rossol, I. etc. " a kind of α of Corynebacterium glutamicum aecD genes encoding, the C-S lyase of β-eliminate activity ", J.Bacteriol, 174 (9): 2968-2977 (1992) with degraded aminoethylcysteine; Tauch, A. etc. " Isoleucine among the Corynebacterium glutamicum ATCC 13032 is taken in by the brQ gene product and instructed ", Arch.Microbiol., 169 (4): 303-312 (1998)
	S59299	trp	Leading gene (promotor)	Herry, D.M. etc. " from the high clone who produces the trp gene cluster of bacterial strain of Corynebacterium glutamicum tryptophane: the evaluation of a sudden change in the trp leader sequence ", Appl.Environ.Microbiol, 59 (3): 791-799 (1993)
U11545					trpD	Anthranilate phosphoribosyl transferase	O ' Gara, J.P. and Dunican, L.K. (1994) " the complete nucleotide sequences of Corynebacterium glutamicum ATCC 21850 tpD genes ", paper, Microbiology Department, University College Galway, Ireland
	U13922	cglIM；cglIR；clgIIR	The II type 5-cytosine(Cyt) methyltransgerase of inferring; The II type restriction endonuclease of inferring; I type of inferring or III type restriction endonuclease	Schafer, A. etc. " from the clone in the DNA district of the encoding stress susceptibility restriction system of Corynebacterium glutamicum ATCC 13032 and characterized and with colibacillary genus between function analysis aspect engaging ", J.Bacteriol.176 (23): 7309-7319 (1994); Schafer, A. etc. " the cglIM gene of the 5-cytosine(Cyt) in the Corynebacterium glutamicum coding McrBC defective escherichia coli bacterial strain ", Gene, 203 (2): 95-101 (1997)
U14965					recA
	U31224	ppx		Ankri, S. etc. " sudden change in the Corynebacterium glutamicum proline(Pro) biosynthetic pathway: the natural bypass of proA step ", J.Bacteriol., 178 (15): 4412-4419 (1996)
U31225					proC	L-proline(Pro): NADP+5-oxydo-reductase	Ankri, S. etc. " sudden change in the Corynebacterium glutamicum proline(Pro) biosynthetic pathway: the natural bypass of proA step ", J.Bacteriol., 178 (15): 4412-4419 (1996)
	U31230	obg；proB；unkdh	The gamma-glutamyl kinases; Similar to the specific 2-hydroxy acid dehydrogenase of D-isomer	Ankri, S. etc. " sudden change in the Corynebacterium glutamicum proline(Pro) biosynthetic pathway: the natural bypass of proA step ", J.Bacteriol., 178 (15): 4412-4419 (1996)

Table 2 (continuing)
	U31281	bioB	The vitamin H synthase	Serebriiskii, I.G., " two newcomers of bio B ultrasonic family: clone, order-checking and the expression of the bio B gene of Methylobacillus flagellatum and Corynebacterium glutamicum ", Gene, 175:15-22 (1996)
U35023					thtR；accBC	Thiosulfate sulfurtransferase; The acyl-CoA carboxylase	Jager, W. etc. " coding is similar to the Corynebacterium glutamicum gene of two domain proteins of biotin carboxylase and biotin carboxyl carrier protein ", Arch.Microbiol., 166 (2); 76-82 (1996)
	U43535	cmr	Multiple drug resistance albumen	Jager, W. etc. " give the Corynebacterium glutamicum gene of multiple drug resistance " in the heterologous host intestinal bacteria, J.Bacteriol., 179 (7): 2449-2451 (1997)
U43536					clpB	Heat shock ATP is conjugated protein
	U53587	aphA-3	3 ' 5 "-aminoglycoside phosphotransferase
U89648						Participate in biosynthetic sequence, the partial sequence do not identified of Histidine in the Corynebacterium glutamicum
	X04960	trpA；trpB；trpC；trpD； TrpE；trpG；trpL	Tryptophan operon	Matsui, K. etc. " the complete nucleotide sequence and the deduced amino acid of brevibacterium tryptophan operon ", Nucleic Acids Res., 14 (24): 10113-10114 (1986)
X07563					lysA	The DAP decarboxylase (in-diaminapimelate decarboxylase, EC 4.1.1.20)	Yeh, P. etc. " nucleotide sequence of the lysA gene of Corynebacterium glutamicum with and express to regulate may mechanism ", Mol.Gen.Genet., 212 (1): 112-119 (1988)
	X14234	EC?4.1.1.31	Phosphoenolpyruvate carboxylase	Eikmanns, B.J. etc. " the Phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, nucleotide sequence and expression ", Mol.Gen.Genet., 218 (2): 330-339 (1989); Lepiniec, L. etc. " Chinese sorghum Phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution ", Plant. Mol.Biol., 21 (3): 487-502 (1993)
X17313					fda	Fructose-bis phosphate aldolase	Von der Osten, C.H. etc. " molecular cloning, nucleotide sequence and the fine-structure distribution of Corynebacterium glutamicum fda gene: Corynebacterium glutamicum fructose-1; texture ratio of 6-bisphosphate aldolase and I class and II class zymohexase is ", Mol.Microbiol.
	X53993	dapA	L-2,3-dihydro 2, dipicolimic acid 2 synthetic enzyme (EC 4.2.1.52)	Bonnassie, S. etc. " from the nucleotide sequence of the dapA gene of Corynebacterium glutamicum ", Nucleic Acids Res., 18 (21): 6421 (1990)
X54223						The AttB related locus	Cianciotto, N. etc. " the dna sequence dna homology between the attP site of corynebacterium diphtheriae, ulcer rod bacillus (Corynebacterium ulcerans) and Corynebacterium glutamicum attB related locus and λ rod bacillus phage ", FEMS, Microbiol, Lett., 66:299-302 (1990)
	X54740	argS；lysA	Arginyl-tRNA synthetase; Diaminapimelate decarboxylase	Marcel, T. etc. " nucleotide sequence in Corynebacterium glutamicum lysA upstream region of gene district and group structure ", Mol. Microbiol., 4 (11): 1819-1830 (1990)

Table 2 (continuing)
	X55994	trpL；trpE	The leading peptide of inferring; O-amino benzoyl acid synthase component I	Heery, D.M. etc. " nucleotide sequence of Corynebacterium glutamicum trpE gene ", Nucleic Acids Res., 18 (23): 7138 (1990)
X56037					thrC	Threonine synthase	Han, K.S. etc. " molecular structure of Corynebacterium glutamicum threonine synthase gene ", Mol.Microbiol., 4 (10): 1693-1702 (1990)
	X56075	The attB-related locus	Attachment site	Cianciotto, N. etc. " the dna sequence dna homology between the attP site of corynebacterium diphtheriae, ulcer rod bacillus (Corynebacterium ulcerans) and Corynebacterium glutamicum att B related locus and λ rod bacillus phage ", FEMS.Microbiol, Lett., 66:299-302 (1990)
X57226					lysC-α；lysC-β； asd	E.C. 2.7.2.4. α subunit; E.C. 2.7.2.4. β subunit; Aspartic acid β semialdehyde desaturase	Kalinowski, J. etc. " from the genetics and the biochemical analysis of the E.C. 2.7.2.4. of Corynebacterium glutamicum ", Mol.Microbiol, 5 (5): 1197-1204 (1991); Kalinowski, J. etc. " aspartokinase gene lysC α and lysC β are overlapping and adjacent with aspartic acid β semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum ", Mol.Gen.Genet., 224 (3): 317-324 (1990)
	X59403	gap；pgk；tpi	Glyceraldehyde-3-phosphate; Phosphoglyceric kinase; Triose-phosphate isomerase	Eikmanns, B.J. " Corynebacterium glutamicum gene of a kind of coding three kinds of glycolytic ferment glyceraldehyde-3-phosphate dehydrogenases, phosphoglyceric kinase and triose-phosphate isomerases bunch evaluation, sequential analysis and expression ", J.Bacteriol., 174 (19): 6076-6086 (1992)
X59404					gdh	Glutamate dehydrogenase	Bormann, E.R. etc. " analysis of molecules of the Corynebacterium glutamicum gdh gene of coding glutamate dehydrogenase ", Mol. Microbiol., 6 (3): 317-326 (1992)
	X60312	Lys1	L-Methionin permease	Seep-Feldhaus, A.H. etc. " participate in the analysis of molecules of the Corynebacterium glutamicum lys1 gene of Methionin absorption ", Mol.Microbiol., 5 (12): 2995-3005 (1991)
X66078					Cop1	Ps1 albumen	Joliff, G. etc. " clone and nucleotide sequence of the csp1 gene of one of two kinds of main secretory proteins of coding Corynebacterium glutamicum PS1: the N-terminal district of the derivation of PS1 is similar to Mycobacterium antigen 85 complex bodys ", Mol.Microbiol., 6 (16): 2349-2362 (1992)
	X66112	glt	Oxalacetic transacetase	Eikmanns, B.J. etc. " cloned sequence, expression and the transcription analysis of the Corynebacterium glutamicum gltA gene of coding Oxalacetic transacetase ", Microbiol., 140:1817-1828 (1994)
X67737					dapB	Dihydro 2, the dipicolimic acid 2 reductase enzyme
	X69103	csp2	S-layer proteins PS2	Peyret, J.L. etc. " characterized of the cspB gene of a kind of orderly S-layer proteins PS2 in the coding Corynebacterium glutamicum ", Mol.Microbiol, 9 (1): 97-109 (1993)
X69104						The IS3 insertion element of being correlated with	Bonamy, C. etc. " evaluation of the relevant insertion sequence IS 1206 of a kind of Corynebacterium glutamicum IS3 and kind system analyze ", Mol.Microbiol., 14 (3): 571-581 (1994)

Table 2 (continuing)
	X70959	leuA	Isopropylmalate synthase	Patek, M. etc. " leucine in the Corynebacterium glutamicum is synthetic: the enzymic activity of leuA, structure and leuA inactivation are to the influence of Methionin synthetic ", Appl, Environ.Microbiol., 60 (1): 133-140 (1994)
X71489					icd	Isocitric enzyme (NADP+)	Eikmanns, B.J. etc. " cloned sequence analysis, expression and the inactivation of the Corynebacterium glutamicum icd gene of coding isocitric enzyme and the biochemical character of this enzyme are identified ", J.Bacteriol., 177 (3): 774-782 (1995)
	X72855	GDHA	Glutamate dehydrogenase (NADP+)
X75083， X70584					mtrA	The 5-methyl tryptophan resistance	Heery, D.M. etc. " from the high sequence of producing bacterial strain coding 5-methyl tryptophan resistance of Corynebacterium glutamicum tryptophane ", Biochem.Biophys.Res.Commun., 201 (3): 1255-1262 (1994)
	X75085	recA		Fitzpatrick, R. etc. " structure and the characterized of the recA mutant strain of Corynebacterium glutamicum and brevibacterium ", Appl.Microbiol.Biotechnol., 42 (4): 575-580 (1994)
X75504					aceA；thiX	The part isocitrate lyase;	Reinscheid, D.J. etc. " from the characterized of the isocitrate lyase gene of Corynebacterium glutamicum and the biochemical analysis of this enzyme ", J.Bacteriol., 176 (12): 3474-3483 (1994)
	X76875		ATP enzyme β subunit	Ludwig, W. etc. " the bacterium kind system based on EF-T u and the analysis of atp synthase beta subunit gene comparative sequences is related ", Antonie Van Leeuwenhoek, 64:285-305 (1993)
X77034					tuf	EF-T u	Ludwig, W. etc. " the bacterium kind system based on EF-T u and the analysis of atp synthase beta subunit gene comparative sequences is related ", Antonie Van Leeuwenhoek, 64:285-305 (1993)
	X77384	recA		Billman-Jacobe, H. " from the nucleotide sequence of the recA gene of Corynebacterium glutamicum ", DNA Seq., 4 (6): 403-404 (1994)
X78491					aceB	Malate synthase	Reinscheid, D.J. etc. " from the malate synthase of the Corynebacterium glutamicum pta-ack operon of coding phosphoric acid CAT: sequential analysis ", Microbiology, 140:3099-3108 (1994)
	X80629	16S?rDNA	The 16S ribosome-RNA(rRNA)	Rainey, F.A. etc. " the kind system of Rhod (Rhodococcus) and Nocardia (Norcardia) takes place to analyze and the Nocardia evidence that evolution originates from from the rhodococcus radiating ", Microbiol., 141:523-528 (1995)
X81191					gluA；gluB；gluC； gluD	The L-glutamic acid shooting system	Kronemeyer, W. etc. " gluABCD bunch structure of coding Corynebacterium glutamicum L-glutamic acid shooting system ", J.Bacteriol, 177 (5): 1152-1158 (1995)
	X81379	dapE	The succinyl-diaminopimelic acid takes off the succinyl enzyme	Wehrmann, A. etc. " analyses of the different dna fragmentations of the Corynebacterium glutamicum of complementary intestinal bacteria dapE ", Microbiology, 40:3349-56 (1994)

Table 2 (continuing)
	X82061	16S?rDNA	The 16S ribosome-RNA(rRNA)	Ruimy, R. etc. " the kind system by the Corynebacterium of small subunit ribosomal dna sequence analytical derivation takes place ", Int.J.Syst.Bacteriol., 45 (4): 740-746 (1995)
X82928					asd；lysC	Aspartate-semialdehyde dehydrogenase;	Serebrijski, I. etc. " the multiple copied inhibition that causes by the asd gene in the proA mutant and the osmotic stress dependency complementation that causes by allos proA ", J.Bacteriol., 177 (24): 7255-7260 (1995)
	X82929	proA	Gamma-glutamyl phosphoric acid reduction enzyme	Serebrijski, I. etc. " the multiple copied inhibition that causes by the asd gene in the proA mutant and the osmotic stress dependency complementation that causes by allos proA ", J.Bacteriol., 177 (24): 7255-7260 (1995)
X84257					16S?rDNA	The 16S ribosome-RNA(rRNA)	Pascual, C. etc. " the kind system based on the Corynebacterium of 16S rRNA gene order analyzes ", Int. J.Syst.Bacteriol, 45 (4): 724-728 (1995)
	X85965	aroP；dapE	The aromatic amino acid permease;	Wehrmann etc. " functional analysis of the flanking sequence of Corynebacterium glutamicum proline(Pro) dapE discloses the existence of the aroP of coding aromatic amino acid translocator ", J.Bacteriol., 177 (20): 5991-5993 (1995)
X86157					argB；argC；argD； argF；argJ	Acetylglutamate kinase; N-acetyl-gamma-glutamyl phosphoric acid reduction enzyme; The acetylornithice transaminase; Ornithine carbamyl transferase; Glutamic acid N-acetyltransferase	Sakanyan, V. etc. " arginine biosynthesizing ethanoyl round-robin gene and enzyme in the Corynebacterium glutamicum: the enzyme in the early stage step of arginine pathway is evolved ", Microbiology, 142:99-108 (1996)
	X89084	pta；ackA	The phosphoric acid acetyltransferase; E.C. 2.7.2.1	Reinscheid, D.J. etc. " clone, sequential analysis, expression and the inactivation of the Corynebacterium glutamicum pta-ack operon of coding phosphoric acid CAT and E.C. 2.7.2.1 ", Microbiology, 145:503-513 (1999)
X89850					attB	Attachment site	Le Marrec, C. etc. " hereditary feature of the phi AAU2 site-directed integration function of infection " golden yellow Arthrobacter (Arthrobacter aureus) C70 " is identified ", J.Bacteriol, 178 (7): 1996-2004 (1996)
	X90356		Promoter fragment F1	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90357						Promoter fragment F2	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90358		Promoter fragment F10	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90359						Promoter fragment F13	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)

Table 2 (continuing)
	X90360		Promoter fragment F22	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90361						Promoter fragment F34	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90362		Promoter fragment F37	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90363						Promoter fragment F45	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90364		Promoter fragment F64	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90365						Promoter fragment F75	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90366		Promoter fragment PF101	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90367						Promoter fragment PF104	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90368		Promoter fragment PF109	Patek, M. etc. " from the promotor of Corynebacterium glutamicum: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X93513					amt	The ammonium movement system	Siewe, R.M. etc. " Corynebacterium glutamicum (methyl) ammonium is taken in the function and the hereditary feature of carrier and identified ", J. Biol.Chem., 271 (10): 5398-5403 (1996)
	X93514	betP	The trimethyl-glycine movement system	Peter, H. etc. " Corynebacterium glutamicum betP gene isolation, characterized and the expression of codes match solute trimethyl-glycine movement system ", J.Bacteriol., 178 (17): 5229-5234 (1996)
X95649					orf4		Patek, M. etc. " coding participates in the evaluation and the transcription analysis of the Corynebacterium glutamicum dapB-ORF2-dapA-ORF4 operon of two kinds of enzymes of L-Methionin synthetic ", Biotechnol.Lett., 19:1113-1117 (1997)
	X96471	lysE；lysG	Methionin output albumen; Albumen is regulated in Methionin output	Vrljic, M. etc. " the novel type translocator with novel type cell function: ", Mol. Microbiol., 22 (5): 815-826 (1996) from the L-Methionin output of Corynebacterium glutamicum

Table 2 (continuing)
	X96580	panB；panC；xylB	3-methyl-2-ketone butyric acid hydroxymethyl transferases; Pantoic acid-Beta-alanine ligase enzyme; Xylulokinase	Sahm, H. etc. " the synthetic and excessive production that panBC and coding L-Xie Ansuan synthetic gene is applied to D-pantothenic acid of the D-pantothenic acid in the Corynebacterium glutamicum ", Appl.Environ.Microbiol., 65 (5): 1973-1979 (1999)
X96962						Insertion sequence IS1207 and transposase
	X99289		Elongation factor P	Ramos, A. etc. " coded amino acid is produced clone, order-checking and the expression of the gene of elongation factor P in the bacterium brevibacterium (Corynebacterium glutamicum ATCC 13869) ", Gene, 198:217-222 (1997)
Y00140					thrB	Homoserine kinase	Mateos, L.M. etc. " nucleotide sequence of the homoserine kinase of brevibacterium (thrB) gene ", Nucleic Acids Res., 15 (9): 3922 (1987)
	Y00151	ddh	In-diaminopimelic acid D-desaturase (EC 1.4.1.16)	Ishino, S. etc. " from the Corynebacterium glutamicum-nucleotide sequence of diaminopimelic acid D-dehydrogenase gene ", Nucleic Acids Res., 15 (9): 3917 (1987)
Y00476					thrA	Homoserine dehydrogenase	Mateos, L.M. etc. " nucleotide sequence of the homoserine dehydrogenase of brevibacterium (thrA) gene ", Nucleic Acids Res., 15 (24): 10598 (1987)
	Y00546	hom；thrB	Homoserine dehydrogenase; Homoserine kinase	Peoples, O.P. etc. " nucleotide sequence and the fine-structure distribution of Corynebacterium glutamicum hom-thrB operon ", Mol.Microbiol., 2 (1): 63-72 (1988)
Y08964					murC；ftsQ/divD；ftsZ	UPD-N-acetylmurami-L-Ala ligase enzyme; Divide initial albumen or cell fission albumen; Cell fission albumen	Honrubia, MP. etc. " from evaluation, characterized and the genome structure of the ftsZ gene of brevibacterium ", Mol.Gen.Genet., 259 (1): 97-104 (1998)
	Y09163	putP	High affinity proline(Pro) movement system	Peter, H. etc. " characterized of the low affinity shooting system of the separation of the putP gene of Corynebacterium glutamicum proline(Pro) and coupling solute ", Arch.Microbiol., 168 (2): 143-151 (1997)
Y09548					pyc	Pyruvate carboxylase	Peters-Wendisch, P.G. etc. " from the pyruvate carboxylase of Corynebacterium glutamicum: the characterized of pyc gene, expression and inactivation ", Microbiology, 144:915-927 (1998)
	Y09578	leuB	3-Isopropylmalate dehydrogenase	Patek, M. etc. " from the analysis of the leuB gene of Corynebacterium glutamicum ", Appl.Microbiol, Biotechnol., 50 (1): 42-47 (1998)
Y12472						Attachment site phage Phi-16	Moreau, S. etc. " site-directed integration of excellent bacillus phage Phi-16: the structure of integrative vector ", Microbiol., 145:539-548 (1999)
	Y12537	proP	Proline(Pro)/ectoine shooting system albumen	Peter, H. etc. " Corynebacterium glutamicum has second carrier of four kinds of coupling solutes: evaluation, order-checking and the characterized of proline(Pro)/ectoine shooting system ProP and ectoine/ proline(Pro)/trimethyl-glycine carrier EctP ", J.Bacteriol., 180 (22): 6005-6012 (1998)

Table 2 (continuing)
	Y13221	GlnA	Glutamine synthetase I	Jakoby, M. etc. " separation of the Corynebacterium glutamicum glnA gene of coding glutamine synthetase I ", FEMS Microbiol.Lett., 154 (1): 81-88 (1997)
Y16642					Lpd	Dihydrolipoamide dehydrogenase
	Y18059		Attachment site rod bacillus phage 304L	Moreau, “ ﹠amp such as S.; Phi; The analysis of 304L integration function: a kind of intergrase assembly in the excellent bacillus phage ", Virology, 255 (1): 150-159 (1999)
Z21501					ArgS; LysA	Arginyl-tRNA synthetase; Diaminopimelic acid decarbonylation enzyme (part)	Oguiza, J.A. etc. " gene of coding Arginyl-tRNA synthetase is arranged in the upstream of brevibacterium lysA gene: regulate argS-lysA bunch of expression by arginine ", J.Bacteriol., 175 (22): 7356-7362 (1993)
	Z21502	DapA; DapB	Dihydro 2, the dipicolimic acid 2 synthase; Dihydro 2, the dipicolimic acid 2 reductase enzyme	Pisabarro, A. etc. " the gene cluster coding dihydro 2 of three kinds of genes of brevibacterium (dapA, orf2 and dapB); the third polypeptide of dipicolimic acid 2 reductase enzyme and a kind of Unknown Function ", J.Bacteriol, 175 (9): 2743-2749 (1993)
Z29563					ThrC	Threonine synthase	Malumbres, M. etc. " analysis and the expression of the thrC gene of coded threonine synthase ", Appl. Environ.Microbiol., 60 (7) 2209-2219 (1994)
	ZA6753	16S rDNA	The gene of 16S ribosome-RNA(rRNA)
ZA9822					SigA	The SigA Sigma Factors	Oguiza, J.A. etc. " a plurality of Sigma Factors genes in the brevibacterium: the characterized of sigA and sigB ", J.Bacteriol., 178 (2): 550-553 (1996)
	Z49823	GalE; DtxR	Catalytic activity UDP-semi-lactosi 4-epimerase; Diphtheria toxin is regulated albumen	Oguiza, J.A. etc. " the galE gene and the dmdR genetic transcription coupling of brevibacterium coding UDP-semi-lactosi 4-epimerase ", Gene, 177:103-107 (1996)
Z49824					OrfI; SigB	The SigB Sigma Factors	Oguiza, J.A. etc. " a plurality of Sigma Factors genes in the brevibacterium: the characterized of sigA and sigB ", J.Bacteriol., 178 (2): 550-553 (1996)
	Z66534		Transposase	Correia, A. etc. " clone and the characterized that are present in the IS sample element in brevibacterium ATCC 13869 genomes ", Gene, 170 (1): 91-94 (1996)
The sequence of 1 this gene is published in the specified reference.Yet the sequence that the present inventor obtains obviously is longer than the form of being announced.Think that the form of being announced depends on incorrect initiator codon, therefore only represent the fragment of true coding region.

Table 3: can be used to implement Corynebacterium of the present invention and brevibacterium sp bacterial strain

Bacterial classification	ATCC	FERM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
									Brevibacterium ammoniagenes (Brevibacterium ammoniagenes)	21054
Brevibacterium ammoniagenes	19350
									Brevibacterium ammoniagenes	19351
Brevibacterium ammoniagenes	19352
									Brevibacterium ammoniagenes	19353
Brevibacterium ammoniagenes	19354
									Brevibacterium ammoniagenes	19355
Brevibacterium ammoniagenes	19356
									Brevibacterium ammoniagenes	21055
Brevibacterium ammoniagenes	21077
									Brevibacterium ammoniagenes	21553
Brevibacterium ammoniagenes	21580
									Brevibacterium ammoniagenes	39101
Brevibacterium?butanicum	21196
									Corynebacterium glutamicum (Brevibacterium divaricatum)	21792	P928
Brevibacterium flavum (Brevibacterium flavum)	21474
									Brevibacterium flavum	21129
Brevibacterium flavum	21518
									Brevibacterium flavum			B11474
Brevibacterium flavum			B11472
									Brevibacterium flavum	21127
Brevibacterium flavum	21128
									Brevibacterium flavum	21427
Brevibacterium flavum	21475
									Brevibacterium flavum	21517
Brevibacterium flavum	21528
									Brevibacterium flavum	21529
Brevibacterium flavum			B11477
									Brevibacterium flavum			B11478
Brevibacterium flavum	21127
									Brevibacterium flavum			B11474
Xi Shi tyrothricin (Brevibacterium healii)	15527
									Ketoisocaproic tyrothricin (Brevibacterium ketoglutamicum)	21004
The ketoisocaproic tyrothricin	21089
									The ketoisocaproic tyrothricin	21914
Brevibacterium				70
									Brevibacterium				74
Brevibacterium				77
									Brevibacterium	21798
Brevibacterium	21799
									Brevibacterium	21800
Brevibacterium	21801
									Brevibacterium			B11470
Brevibacterium			B11471
									Brevibacterium	21086
Brevibacterium	21420
									Brevibacterium	21086

Brevibacterium	31269
									Extension brevibacterium (Brevibacterium linens)	9174
Extension brevibacterium	19391
									Extension brevibacterium	8377
Brevibacterium?paraffiolvticum					11160
									Tyrothricin (Brevibacteriun spec.)						717.73
Tyrothricin						717.73
									Tyrothricin	14604
Tyrothricin	21860
									Tyrothricin	21864
Tyrothricin	21865
									Tyrothricin	21866
Tyrothricin	19240
									Corynebacterium acctoacidophlum (Corynebacterium acetoacidophilum)	21476
Corynebacterium acctoacidophlum	13870
									Vinegar paddy rod bacillus (Corynebacterium acetoglutamiphilum)			B11473
Vinegar paddy rod bacillus			B11475
									Vinegar paddy rod bacillus	15806
Vinegar paddy rod bacillus	21491
									Vinegar paddy rod bacillus	31270
Have a liking for acetyl rod bacillus (Corynebacterium acetophilum)			B3671
									Produce ammonia rod bacillus	6872						2399
Produce ammonia rod bacillus	15511
									Corynebacterium?fujiokense	21496
Corynebacterium glutamicum	14067
									Corynebacterium glutamicum	39137
Corynebacterium glutamicum	21254
									Corynebacterium glutamicum	21255
Corynebacterium glutamicum	31830
									Corynebacterium glutamicum	13032
Corynebacterium glutamicum	14305
									Corynebacterium glutamicum	15455
Corynebacterium glutamicum	13058
									Corynebacterium glutamicum	13059
Corynebacterium glutamicum	13060
									Corynebacterium glutamicum	21492
Corynebacterium glutamicum	21513
									Corynebacterium glutamicum	21526
Corynebacterium glutamicum	21543
									Corynebacterium glutamicum	13287
Corynebacterium glutamicum	21851
									Corynebacterium glutamicum	21253
Corynebacterium glutamicum	21514
									Corynebacterium glutamicum	21516
Corynebacterium glutamicum	21299
									Corynebacterium glutamicum	21300
Corynebacterium glutamicum	39684
									Corynebacterium glutamicum	21488
Corynebacterium glutamicum	21649

Corynebacterium glutamicum	21650
									Corynebacterium glutamicum	19223
Corynebacterium glutamicum	13869
									Corynebacterium glutamicum	21157
Corynebacterium glutamicum	21158
									Corynebacterium glutamicum	21159
Corynebacterium glutamicum	21355
									Corynebacterium glutamicum	31808
Corynebacterium glutamicum	21674
									Corynebacterium glutamicum	21562
Corynebacterium glutamicum	21563
									Corynebacterium glutamicum	21564
Corynebacterium glutamicum	21565
									Corynebacterium glutamicum	21566
Corynebacterium glutamicum	21567
									Corynebacterium glutamicum	21568
Corynebacterium glutamicum	21569
									Corynebacterium glutamicum	21570
Corynebacterium glutamicum	21571
									Corynebacterium glutamicum	21572
Corynebacterium glutamicum	21573
									Corynebacterium glutamicum	21579
Corynebacterium glutamicum	19049
									Corynebacterium glutamicum	19050
Corynebacterium glutamicum	19051
									Corynebacterium glutamicum	19052
Corynebacterium glutamicum	19053
									Corynebacterium glutamicum	19054
Corynebacterium glutamicum	19055
									Corynebacterium glutamicum	19056
Corynebacterium glutamicum	19057
									Corynebacterium glutamicum	19058
Corynebacterium glutamicum	19059
									Corynebacterium glutamicum	19060
Corynebacterium glutamicum	19185
									Corynebacterium glutamicum	13286
Corynebacterium glutamicum	21515
									Corynebacterium glutamicum	21527
Corynebacterium glutamicum	21544
									Corynebacterium glutamicum	21492
Corynebacterium glutamicum			B8183
									Corynebacterium glutamicum			B8182
Corynebacterium glutamicum			B12416
									Corynebacterium glutamicum			B12417
Corynebacterium glutamicum			B12418
									Corynebacterium glutamicum			B11476
Corynebacterium glutamicum	21608
									Lily hedysarum scoparium bacillus (Corynebacterium lilium)		P973
Corynebacterium?nitrilophilus	21419				11594
									Rod bacillus (Corynebacterium spec.)		P4445
The rod bacillus		P4446
									The rod bacillus	31088

The rod bacillus	?31089
									The rod bacillus	?31090
The rod bacillus	?31090
									The rod bacillus	?31090
The rod bacillus	?15954							20145
									The rod bacillus	?21857
The rod bacillus	?21862
									The rod bacillus	?21863

ATCC: American type culture collection, Rockville, MD, USA

FERM: fermentation research institute, Chiba, Japan

NRRL: agricultural research institute culture collection center, Northern Regional ResearchLaboratory, Peoria, IL, USA

CECT: Spain typical case's culture collection center, Valencia, Spain

NCIMB: state-run industry and marine microorganism preservation company limited, Aberdeen, Britain

CBS: fungi strain preservation center, Baarn, Holland

NCTC: state-run typical culture collection center, London, Britain

DSMZ: Germany microbial preservation center, Braunschweig, Germany

Relevant reference is referring to Sugawara, (1993) World directory of collections ofcultures of microorganisms:Bacteria such as H., fungi and yeasts (the 4th edition), World federation forculture collections world data center on microorganisms, Saimata, Japan.

Table 4: sequence alignment result

ID#	Length (NT)	Genbank hits	Swinging seat	Registration number	The title that Genbank hits	Genbank hits The source	Homology % (GAP)	Date of entry
									Rxa00026	1509	GB_RO:MMHC310M6 GB_HTG2:AC007029 GB_HTG2:AC007029	158,405 119,007 119007	AF109906 AC007029 AC007029	House mouse MHC class III district RD gene, the part coding region; Bf, C2, G9A, NG22, G9, HSP70, HSP70, HSC70t and smRNP gene, complete coding region; The G7A gene, the part coding region; And unknown gene.The people clones DJ0855F16, * *It is in progress to check order * *, 1 non-sequential segments.The people clones DJ0855F16, * *It is in progress to check order * *, 1 non-sequential segments.	House mouse (Mus musculus) people (Homo sapiens) people	38,003 37,943 37,943	1998-12-10 99-04-07 99-04-07
Rxa00072
									Rxa00111	1116	GB_BA1:SAUSIGA GB_BA1:SC5B8 GB_BA2:AE001767	2,748 28,500 9086	M94370 AL022374 AE001767	Orange stake bacterium Sigma Factors (sigA) gene, complete coding region.Streptomyces coelicolor clay 5B8.The zone 79/136 of Thermotoga maritima complete genome group (section 79 of 136)	Orange stake bacterium (Stigmatella aurantiaca) streptomyces coelicolor (Streptomyces coelicolor) Thermotoga maritima (Thermotoga maritima)	40,435 40,090 35,091	94-08-16 98-04-22 99-06-02
Rxa00112	1314	GB_EST35:AU075536 GB_GSS9:AQ157585 GB_GSS14:AQ510314	418 647 542	AU075536 AQ157585 AQ510314	AU075536 paddy rice seedling rice cDNA clones S0028_2Z, mRNA sequence.Nbxb0009B16r CUGI paddy rice BAC library rice genomic clone nbxb0009B16r, genome summary sequence.Nbxb0095O05f CUGI paddy rice BAC library rice genomic clone nbxb0095O05f, genome summary sequence.	Rice (Oryza sativa) rice rice	39,423 40,867 39,372	99-07-07 98-09-12 1999-05-04
									Rxa00133	936	GB_BA1:SC2G5 GB_EST7:W64291 GB_PR3:AC005624	38,404 515 39594	AL035478 W64291 AC005624	Streptomyces coelicolor clay 2G5.Md98h12.r1 Soares mice embryonic NbME13.5 14.5 house mouse cDNA clone IMAGE:386087 is similar to 5 ' of gb:L26528 house mouse Rab11b mRNA, complete coding region (mouse); The mRNA sequence.No. 19 karyomit(e)s of people, clay R30017, complete sequence.	Streptomyces coelicolor house mouse people	41,170 35,306 39,054	99-06-11 96-06-10 98-09-06
Rxa00137	1212	GB_BA2:AF124600 GB_BA1:MTCY159 GB_BA1:MT3DEHQ	4,115 33,818 3437	AF124600 Z83863 X59509	Corynebacterium glutamicum chorismate synthase (aroC), shikimate kinase (aroK) and 3-Dehydroquinate synthase (aroB) gene, complete coding region; With kytoplasm peptase (pepQ) gene of inferring, part coding region.Mycobacterium tuberculosis H37Rv complete genome group; Section 111/162.Mycobacterium tuberculosis, the gene of 3-Dehydroquinate synthase and 3-dehydroquinase.	Corynebacterium glutamicum mycobacterium tuberculosis (Mycobacterium tuberculosis) mycobacterium tuberculosis	99,867 40,959 52,583	1999-05-04 98-06-17 93-06-30
									Rxa00139	834	GB_BA1:BLELONP GB_PL1:SPAC24C9 GB_HTG1:CEY102A5 _ 1	738 38,666 110000	X99289 Z98601 Z99711	The gene of brevibacterium code extension factor P.Schizosaccharomyces pombe I karyomit(e) clay c24C9.Caenorhabditis elegans V karyomit(e) clone Y102A5, * *It is in progress to check order * *, be non-sequential segments.	Corynebacterium glutamicum schizosaccharomyces pombe (Schizosaccharomyces pombe) Caenorhabditis elegans	100,000 35,230 37,775	97-11-01 99-02-24 Z99711

Table 4 (continuing)

Rxa00152	1419	GB_BA1:MTCY277 GB_BA1:MSGY456 GB_BA2:AF002133	38,300 37,316 15437	Z79701 AD000001 AF002133	Mycobacterium tuberculosis H37Rv complete genome group; Section 65/162.Derive from the mycobacterium tuberculosis sequence of clone y456.Mycobacterium avium bacterial strain GIR10 transcriptional (mav81) gene; the part coding region; aconitase (acn), invasin 1 (inv1), invasin 2 (inv2), transcriptional (moxR), keto acyl base reductase enzyme (fabG), alkene acyl alcohol reductase enzyme (inhA) and ferrochelatase (mav272) gene, complete coding region.	Mycobacterium tuberculosis mycobacterium tuberculosis mycobacterium avium (Mycobacterium avium)	58,500 38,913 64,009	98-06-17 1996-12-03 1998-03-26
									Rxa00226	948	GB_PR3:AC005756 GB_GSS5:AQ818463 GB_GSS5:AQ782337	43,299 413 832	AC005756 AQ818463 AQ782337	No. 19 karyomit(e)s of people, fosmid 39347, complete sequence.HS_5250_A2_B08_SP6E RPCI-11 human male BAC library people's gene group clone flat board=826 row=16 row=C, genome summary sequence.Human genome sperm library D people's gene group clone flat board=3184 row=23 row=P of HS_3184_B1_H12_T7C CIT approval, genome summary sequence.	The people everybody	36,209 37,288 35,917	1998-10-12 99-08-26 99-08-02
Rxa00249	980	GB_BA2:AF035608 GB_BA1:AB017641 GB_BA2:AF002133	3,614 17,101 15437	AF035608 AB017641 AF002133	Pseudomonas aeruginosa ATP sulfurylase small subunit (cysD) and ATP sulfurylase GTP binding subunit/APS kinases (cysN) gene, complete coding region.The gene of grey micromonospora polyketide synthase, complete coding region.Mycobacterium avium bacterial strain GIR10 transcriptional (mav81) gene; the part coding region; aconitase (acn), invasin 1 (inv1), invasin 2 (inv2), transcriptional (moxR), keto acyl base reductase enzyme (fabG), alkene acyl alcohol reductase enzyme (inhA) and ferrochelatase (mav272) gene, complete coding region.	Pseudomonas aeruginosa (Pseudomonas aeruginosa) grey micromonospora (Micromonospora griseorubida) mycobacterium avium	50,205 40,266 38,429	98-06-01 99-04-02 1998-03-26
									Rxa00299	1101	GB_BA2:CORCSLYS GB_BA1:CGECTP GB_BA2:AF181035	2,821 2,719 5922	M89931 AJ001436 AF181035	Corynebacterium glutamicum β C-S lyase (aecD) and branched-chain amino acid are taken in carrier (brnQ) gene, protein Y hbw (yhbw) gene of complete coding region and supposition, part coding region.Corynebacterium glutamicum ectP gene.The red bacterium glycogen of class ball utilizes operon, complete sequence.	The red bacterium of Corynebacterium glutamicum Corynebacterium glutamicum class ball (Rhodobacter sphaeroides)	100,000 41,143 36,701	98-06-04 98-11-20 99-09-07
Rxa00332	825	GB_BA1:CGTHRC GB_PAT:109078 GB_PR3:HSJ333B15	3,120 3,146 73666	X56037 109078 AL109954	The thrC gene of Corynebacterium glutamicum threonine synthase (EC 4.2.99.2).Derive from the sequence 4 of patent WO8809819.Derive from No. 20 chromosomal human DNA sequences of clone 333B15, complete sequence.	The people of Corynebacterium glutamicum the unknown	37,730 38,700 37,203	97-06-17 1994-12-02 99-11-23
									Rxa00470	1392	GB_PL2:DCPCNAM	865	X62977	The mRNA of Radix Dauci Sativae proliferating cell nuclear antigen (PCNA).	Radix Dauci Sativae (Daucus carota)	37,914	99-09-30

Table 4 (continuing)

		GB_PL2:AC006267 GB_BA1:TT10SARNA	101,644 721	AC006267 Y15063	Arabidopis thaliana BAC F9M13 is near the chromosomal 21.5cM of IV, complete sequence.Thermus thermophilus 10Sa rna gene.	Arabidopis thaliana (Arabidopsis thaliana) thermus thermophilus (Thermus thermophilus)	36,158 39,494	99-04-27 98-08-18
									Rxa00471	813	GB_BA1:SERERYAA GB_PAT:AR049367 GB_BA1:SERERYAA	11,219 11,219 11219	M63676 AR049367 M63676	First ORF of red saccharopolyspora eryA gene, complete coding region.Derive from the sequence 1 of patent US 5824513.First ORF of red saccharopolyspora eryA gene, complete coding region.	The red saccharopolyspora that red saccharopolyspora (Saccharopolyspora erythraea) is unknown	38,781 38,781 38,205	93-04-26 99-09-29 93-04-26
Rxa00499	1404	GB_PR4:AC007206 GB_EST26:AI344735 GB_PR4:AC006479	42,732 462 161837	AC007206 AI344735 AC006479	No. 19 karyomit(e)s of people, clay R27370, complete sequence.Qp05a10.x1 NCI_CGAP_Kid5 people cDNA clones IMAGE:19171143 ', is similar to the ripe associated protein (mankind) of gb:M15800 T lymphocyte; The mRNA sequence.The people clones DJ1051J04, complete sequence.	The people everybody	34,982 42,675 38,462	99-04-04 99-02-02 99-11-11
									Rxa00500	798	GB_PR4:AC006111 GB_HTG2:AF128834 GB_HTG2:AF128834	190,825 196,589 196589	AC006111 AF128834 AF128834	No. 16 karyomit(e) clones of people RPCI-11_461A8, complete sequence.No. 8 karyomit(e) clones of people BAC 57G24 map 8p12, * *It is in progress to check order * *, be non-sequential segments.No. 8 karyomit(e) clones of people BAC 57G24 map 8p12, * *It is in progress to check order * *, be non-sequential segments.	The people everybody	40,736 34,062 34,062	99-07-03 99-02-28 99-02-28
Rxa00501	630	GB_BA1:D86429 GB_HTG1:HS1099D15 GB_HTG1:HS1099D15	5,925 1,301 1301	D86429 AL035456 AL035456	The gene of straight comma saccharopolyspora strain beta galactosidase enzyme, complete coding region.No. 20 karyomit(e) clones of people RP5-1099D15, * *It is in progress to check order * *, be non-sequential segments.No. 20 karyomit(e) clones of people RP5-1099D15, * *It is in progress to check order * *, be non-sequential segments.	Straight comma saccharopolyspora strain (Saccharopolyspora rectivirgula) everybody	53,871 33,546 33,546	1998-12-09 99-11-23 99-11-23
									Rxa00502	1155	GB_BA2:U00015 GB_BA1:U00020 GB_HTG1:HS179I15	42,325 36,947 210672	U00015 U00020 Z84464	Mycobacterium leprae clay B1620.Mycobacterium leprae clay B229.No. 13 karyomit(e) clones of people 179I15, * *It is in progress to check order * *, be non-sequential segments.	Mycobacterium leprae (Mycobacterium leprae) Mycobacterium leprae people	34,783 34,900 32,898	1994-03-01 1994-03-01 97-01-22
Rxa00566	729	GB_BA1:MTV008 GB_BA2:AF071885 GB_BA2:AF013216	63,033 2,188 15742	AL021246 AF071885 AF013216	Mycobacterium tuberculosis H37Rv complete genome group; Section 108/162.Streptomyces coelicolor ATP dependency Clp protease protein hydrolysis subunit 1 (clpP1) and ATP dependency Clp protease protein hydrolysis subunit 2 (clpP2) gene, complete coding region; With ATP dependency Clp protease A TP binding subunit Clpx (clpX) gene, part coding region.Yellow myxococcus Dog (dog), isocitrate lyase (icl), Mls (mls), Ufo (ufo), fumarate hydratase (fhy) and the main subunit of proteoplast (major subunit) be gene (clpP), complete coding region; And acyl group-CoA oxydase (aco) gene, the part coding region.	The yellow myxococcus (Myxococcus xanthus) of mycobacterium tuberculosis streptomyces coelicolor	37,011 62,963 54,683	98-06-17 99-06-29 98-01-28

Table 4 (continuing)

Rxa00567	714	GB_BA1:MTV008 GB_BA1:CGBPHI16 GB_BA1:ECOCLPPA	63,033 962 1236	AL021246 Y12472 J05534	Mycobacterium tuberculosis H37Rv complete genome group; Section 108/162.Corynebacterium glutamicum DNA, attachment site phage Phi-16.Intestinal bacteria ATP dependency clp protease protein hydrolysis component (clpP) gene, complete coding region.	Mycobacterium tuberculosis Corynebacterium glutamicum intestinal bacteria	42,090 40,000 52,119	98-06-17 1999-03-05 93-04-26
									Rxa00621	906	GB_EST1:D36491 GB_IN2:CELC16A3 GB_HTG3:AC009311	360 34,968 160198	D36491 U41534 AC009311	The unpub cDNA Caenorhabditis of CELK033GYF Yuji Kohara elegans cDNA clones yk33g11 5 ', mRNA sequence.Caenorhabditis elegans clay C16A3 people clones NH0311L03, * *It is in progress to check order * *, 3 non-sequential segments.	Caenorhabditis elegans Caenorhabditis elegans people	40,390 35,477 38,636	94-08-08 1999-05-18 99-08-13
Rxa00622	1539	GB_BA1:AB004795 GB_BA1:MBOPII GB_IN2:AF079916	3,039 2,392 2960	AB004795 D38405 AF078916	The gene of pseudomonas two peptidyl aminopeptidases, complete coding region.The gene of lacuna catarrhalis proteolytic enzyme II, complete coding region.Bu Shi trypanosoma bocagei oligopeptidase B (opb) gene, complete coding region.	Pseudomonas (pseudomonas sp.) lacuna catarrhalis (Moraxella lacunata) Bu Shi trypanosoma bocagei (Trypanosoma brucei brucei)	54,721 50,167 48,076	99-02-05 99-02-08 1999-10-08
									Rxa00650	759	GB_BA2:AF161327 GB_PL2:ATAC006533 GB_PL2:ATAC006533	2,021 99,188 99188	AF161327 AC006533 AC006533	Corynebacterium diphtheriae histidine kinase ChrS (chrS) and effect instrumentality ChrA (chrA) gene, complete coding region.Arabidopis thaliana II karyomit(e) BAC F20M17 genome sequence, complete sequence.Arabidopis thaliana II karyomit(e) BAC F20M17 genome sequence, complete sequence.	Corynebacterium diphtheriae Arabidopis thaliana Arabidopis thaliana	51,319 38,051 35,403	99-09-09 1999-05-26 1999-05-26
Rxa00675	915	GB_BA1:SC3C8 GB_PR3:AC005736 GB_IN2:AC005719	33,095 215,441 188357	AL023861 AC005736 AC005719	Streptomyces coelicolor clay 3C8.No. 16 karyomit(e)s of people, BAC clones 462G18 (LANL), complete sequence.Drosophila melanogaster, No. 21 karyomit(e)s, regional 38A5-38B4, BAC clones BACR48M05, complete sequence.	Streptomyces coelicolor people drosophila melanogaster (Drosophila melanogaster)	36,836 42,027 35,531	99-01-15 1998-10-01 1999-10-27
									Rxa00689	1614	GB_PAT:E07294 GB_BA1:BACALDHT GB_BA2:PPU96338	2,975 1,975 5276	E07294 D13846 U96338	The genomic dna of bacstearothermophilus coding desaturase.The aldhT gene of bacstearothermophilus aldehyde dehydrogenase, complete coding region.(pchX) and p-cresol methyl hydroxylase, xanthoprotein subunit (pchF) gene of pseudomonas putida NCIMB 9866 plasmid pRA4000 p-cresol degradation pathway genes, p-Hydroxybenzaldehyde desaturase (pchA), p-cresol methyl hydroxylase, cytopigment subunit precursor (pchC), the unknown, complete coding region.	Bacstearothermophilus (Bacillus stearotherophilus) bacstearothermophilus pseudomonas putida (Pseudomonas putida)	45,677 45,677 44,317	97-09-29 99-02-20 1999-05-13
Rxa00715	918	GB_EST30:AI647104 GB_EST17:AA636159	218 447	AI647104 AA636159	Vn15c01.y1 Stratagene mouse heart (#937316) house mouse cDNA clones IMAGE:1021248 5 ', mRNA sequence.Vn15c01.r1 Stratagene mouse heart (#937316) house mouse cDNA clones IMAGE:1021248 5 ', mRNA sequence.	The house mouse house mouse	58,511 41,195	99-04-29 1997-10-22

Table 4 (continuing)

		GB_EST10:AA184468	583	AA184468	Mt52h05.r1 Stratagene mice embryonic cancer (#937317) house mouse cDNA clones IMAGE:6335615 ', is similar to the proteic mRNA of gb:D10918 mouse ubiquitin sample, partial sequence (mouse); The mRNA sequence.	House mouse	40,426	97-02-12
									Rxa00744	1065	GB_HTG3:AC009855 GB_HTG3:AC009855 GB_PR4:AC005082	167,592 167,592 169737	AC009855 AC009855 AC005082	The people clones 1_C_5, * *It is in progress to check order * *, 13 non-sequential segments.The people clones 1_C_5, * *It is in progress to check order * *, 13 non-sequential segments.The people clones RG271G13, complete sequence.	The people everybody	36,673 36,673 39,557	99-09-03 99-09-03 99-09-08
Rxa00756	1119	GB_BA1:MLCB596 GB_GSS12:AQ368028 GB_HTG3:AC008067	38,426 652 151242	AL035472 AQ368028 AC008067	Mycobacterium leprae clay B596.Toxb0001N11r CUGI tomato BAC library tomato dna group clone toxb0001N11r, genome summary sequence.The people clones NH0303I04, * *It is in progress to check order * *, 2 non-sequential segments.	Mycobacterium leprae (Mycobacterium leprae) tomato (Lycopersicon esculentum) people	54,562 42,657 37,239	99-08-27 99-02-05 99-09-08
									Rxa00773	1266	GB_BA1:MLU15182 GB_BA1:MSGL611CS GB_GSS14:AQ578181	40,123 37,769 728	U15182 L78822 AQ578181	Mycobacterium leprae clay B2266.Mycobacterium leprae clay L611 dna sequence dna.Nbxb0083P08r CUGI paddy rice BAC library rice genomic clone nbxb0083P08r genome summary sequence	Mycobacterium leprae Mycobacterium leprae rice (Oryza sativa)	36,616 35,714 39,246	1995-03-09 96-06-15 99-06-02
Rxa00793	1299	GB_GSS5:AQ769737 GB_BA1:RTU08434 GB_EST31:F33810	519 2,400 243	AQ769737 U08434 F33810	Human genome sperm library D people's gene group clone flat board=3160 row=8 row=M of HS_3160_A2_G04_T7C CIT approval, genome summary sequence.Rhizobium trifolii orotate phosphoribosyl-transferase (pyrE) and fructokinase (frk) gene, complete coding region.HSPD27491 HM3 people cDNA clones s3000041E12, mRNA sequence.	People Rhizobium trifolii people	37,765 40,700 41,564	99-07-28 97-04-16 1999-05-13
									Rxa00820	486	GB_PR4:AC005868 GB_EST8:AA000903 GB_EST25:AI317789	96,180 396 696	AC005868 AA000903 AI317789	People 12q24.2PAC RPCI5-944M2 (the human PAC of Roswell Park Cancer Institute library) complete sequence.Mg38b04.r1 Soares mice embryonic NbME13.5 14.5 house mouse cDNA clone IMAGE:426031 5 ', mRNA sequence.Uj20g09.y1 Sugano mice embryonic mewa house mouse cDNA clones IMAGE:1920544 5 ', is similar to WP:C13C4.5 CE08130 HUCEP-8; The mRNA sequence.	People house mouse house mouse	32,298 42,045 38,557	99-02-27 96-07-18 1998-12-17
Rxa0833	618	GB_PH:BPH6589 GB_HTG2:AC006887 GB_HTG2:AC006887	41,489 215,801 215801	AJ006589 AC006887 AC006887	Phage phi-C31 complete genome group.Caenorhabditis elegans clones Y59H11, * *It is in progress to check order * *, 3 non-sequential segments.Caenorhabditis elegans clones Y59H11, * *It is in progress to check order * *, 3 non-sequential segments.	Phage phi-C13 Caenorhabditis elegans Caenorhabditis elegans	41,806 35,798 35,798	99-04-29 99-02-24 99-02-24
									Rxa00844	957	GB_GSS15:AQ605195	459	AQ605195	Human genome sperm library D people's gene group clone flat board=2136 row=23 row=F of HS_2136_B1_C12_T7C CIT approval, genome summary sequence.	The people	38,074	99-06-10

Table 4 (continuing)

		GB_HTG1:CNS00M8S GB_HTG1:CNS00M8S	214,599 214599	AL079302 AL079302	No. 14 karyomit(e) clones of people R-1089B7, * *It is in progress to check order * *, be sequential segments.No. 14 karyomit(e) clones of people R-1089B7, * *It is in progress to check order * *, be sequential segments.	Everybody	38,120 38,120	1999-10-15 1999-10-15
									Rxa00866	1066	GB_BA1:CGORF4GE N GB_BA1:BLDAPAB GB_PAT:E14517	2,398 3,572 1411	X95649 Z21502 E14517	Corynebacterium glutamicum ORF4 gene.Brevibacterium dihydro 2, dipicolimic acid 2 synthase and dihydro 2, the dapA of dipicolimic acid 2 reductase enzyme and dapB gene.Coding brevibacterium sp dihydro 2, the DNA of dipicolimic acid 2 reductase enzyme.	Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum	99,273 99,301 99,659	1998-03-10 93-08-16 99-07-28
Rxa00877	1788	GB_PAT:I92050 GB_PAT:I78760 GB_BA2:AE000426	567 567 10240	I92050 I78760 AE000426	Derive from the sequence 17 of patent US 5726299.Derive from the sequence 16 of patent US 5693781.The zone 316/400 of e. coli k-12 MG1655 complete genome group.	The intestinal bacteria of unknown the unknown	62,787 62,787 36,456	1998-12-01 98-04-03 98-11-12
									Rxa00903	733	GB_BA2:AE001598 GB_PL2:AF079370 GB_BA2:AE001598	11,136 2,897 11136	AE001598 AF079370 AE001598	The zone 14/103 of Chlamydia pneumoniae complete genome group.Kluyveromyces lactis saccharase (INV1) gene, complete coding region.The zone 14/103 of Chlamydia pneumoniae complete genome group.	Chlamydiophila pneumoniae Kluyveromyces lactis (Kluyveromyces lactis) Chlamydia pneumoniae	32,782 35,849 40,138	1999-03-06 99-08-04 1999-03-08
Rxa00905	924	GB_PR2:HSQ15C24 GB_GSS4:AQ691923 GB_EST37:AI967802	73,192 446 479	AJ239325 AQ691923 AI967802	No. 21 karyomit(e)s of people derive from clay LLNLc116 1C16 and LLNLc116 15C24 map 21q22.3 region D 21S171-LA161, complete sequence.HS_5400_B2_G04_SP6ERPCI-11 human male BAC library people's gene group clone flat board=976 row=8 row=N, genome summary sequence.The two hybrid library Lotus japonicus cDNA clone of Ljimpest12-930-d6 Ljimp λ HybriZap LP930-12-d6 5 ' is similar to 60S ribosome protein L 7/L A, the mRNA sequence.	Everybody is Lotus japonicus	35,076 33,500 41,127	99-09-28 99-07-06 99-08-24
									Rxa00906	627	GB_PAT:I78750 GB_PAT:I92039 GB_PR3:HS929C8	588 588 139190	I78750 I92039 AL020994	Derive from the sequence 6 of patent US 5693781.Derive from the sequence 6 of patent US 5726299.Derive from the human DNA sequence of the chromosome 22 q12.1-12.3 of clone 929C8.Contain CA tumor-necrosis factor glycoproteins, GSS, STS, complete sequence.	The people of unknown the unknown	97,071 97,071 39,016	98-04-03 1998-12-01 99-11-23
Rxa00907	246	GB_PAT:I78750 GB_PAT:I92039 GB_PAT:I78750	588 588 588	I78750 I92039 I78750	Derive from the sequence 6 of patent US 5693781.Derive from the sequence 6 of patent US 5726299.Get the sequence 6 of the sharp US 5693781 of "white expert".	The unknown of unknown the unknown	97,561 97,561 37,222	98-04-03 1998-12-01 98-04-03
									Rxa00961	455	GB_BA1:AB032799 GB_BA2:AF172851 GB_BA1:AB032799	9,077 10,094 9077	AB032799 AF172851 AB032799	The plain biological synthesis gene cluster (vioA, vioB, vioC, vioD) of chromobacterium violaceum purple bar, complete coding region.The plain biological synthesis gene cluster of chromobacterium violaceum purple bar, complete sequence.The plain biological synthesis gene cluster (vioA, vioB, vioC, vioD) of chromobacterium violaceum purple bar, complete coding region.	Chromobacterium violaceum (Chromobacterium violaceum) chromobacterium violaceum chromobacterium violaceum	39,868 42,760 39,551	1999-10-02 99-08-30 1999-10-02

Table 4 (continuing)

Rxa00982	1629	GB_BA1:BLARGS GB_BA1:CGXLYSA GB_PAT:E14508	2,501 2,344 3579	Z21501 X54740 E14508	The argS of brevibacterium Arginyl-tRNA synthetase and diaminapimelate decarboxylase (part) and lysA gene.The argS-lysA operon gene of Corynebacterium glutamicum Arginyl-tRNA synthetase and diaminapimelate decarboxylase (EC 4.1.1.20) upstream.The DNA of coding brevibacterium sp diaminapimelate decarboxylase and arginyl-tRNA synthase.	Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum	39,003 41,435 40,566	1993-12-28 93-06-30 99-07-28
									Rxa00983	1599	GB_HTG2:AC008152 GB_HTG2:AC008152 GB_HTG3:AC008648	24,000 24,000 87249	AC008152 AC008152 AC008648	No. 35 karyomit(e) clones of large-scale leishmania L7936 strain Friedlin, * *It is in progress to check order * *, 4 non-sequential segments.No. 35 karyomit(e) clones of large-scale leishmania L7936 strain Friedlin, * *It is in progress to check order * *, 4 non-sequential segments.No. 5 karyomit(e) clones of people CIT978SKB_186E14, * *It is in progress to check order * *, 22 non-sequential segments.	The large-scale leishmania people of large-scale leishmania (Leishmania major)	38,658 38,658 36,102	99-07-28 99-07-28 99-08-03
Rxa00984	440	GB_BA1:MVINED GB_PAT:E02375 GB_PR4:HUAC00451 3	3,098 1,881 101311	D01045 E02375 AC004513	The DNA of green small single-cell bacteria nedR albumen and neuraminidase, complete coding region.Neuraminidase Gene.No. 16 karyomit(e) BAC clones of people CIT987SK-A-926E7, complete sequence.	The green small single-cell bacteria people of green small single-cell bacteria (Micromonospora viridifaciens)	59,226 59,226 41,204	99-02-02 97-09-29 99-11-23
									Rxa01014	2724	GB_BA1:MTV008 GB_BA1:STMAMPEP N GB_BA1:SC7H2	63,033 2,849 42655	AL021246 L23172 AL109732	Mycobacterium tuberculosis H37Rv complete genome group; Section 108/162.Shallow Streptomyces glaucoviolaceus Aminopeptidase N gene, complete coding region.Streptomyces coelicolor clay 7H2.	The shallow Streptomyces glaucoviolaceus of mycobacterium tuberculosis (Streptomyces lividans) streptomyces coelicolor A3 (2)	56,167 57,067 37,551	98-06-17 1994-05-18 99-08-02
Rxa01059	732	GB_HTG3:AC008154 GB_HTG3:AC008154 GB_EST32:AI756574	172,241 172,241 299	AC008154 AC008154 AI756574	No. 7 karyomit(e)s of people, * *It is in progress to check order * *, 26 non-sequential segments.No. 7 karyomit(e)s of people, * *It is in progress to check order * *, 26 non-sequential segments.Ea02f10.y1 Eimeria M5-6 merozoite stage eimeria avium cDNA 5 ', the mRNA sequence.	Everybody eimeria avium (Eimeria tenella)	39,499 39,499 37,793	99-09-08 99-09-08 99-06-23
									Rxa01073	954	GB_BA1:BACOUTB GB_PR4:AC007938 GB_PL2:ATAC006282	1,004 167,237 92577	M15811 AC007938 AC006282	The proteic outB gene of Bacillus subtilus coding sporulation, complete coding region.People from 7q31 clones UWGC:djs201, complete sequence.Arabidopis thaliana II karyomit(e) BACF13K3 genome sequence, complete sequence.	Bacillus subtilus people Arabidopis thaliana	53,723 34,322 36,181	93-04-26 99-07-01 1999-03-13
Rxa01120	1401	GB_BA1:MTV008 GB_BA1:CAJ10321	63,033 6710	AL021246 AJ010321	Mycobacterium tuberculosis H37Rv complete genome group; Section 108/162.Crescent handle bacillus part tig gene and clpP, cicA, clpX, lon gene.	Mycobacterium tuberculosis crescent handle bacillus (Caulobacter crescentus)	36,715 63,311	98-06-17 1998-10-01

Table 4 (continuing)

Rxa01147	1383	GB_BA2:AF150957 GB_PR3:HS408N23 GB_BA2:AE001227 GB_PR3:HS408N23	4,440 97,916 26,849 97916	AF150957 Z98048 AE001227 Z98048	Brasil diazotrophic spirillum triggers the factor (tig), heat shock protein ClpP (clpP) and heat shock protein ClpX (clpX) gene, complete coding region; With Lon proteolytic enzyme (lon) gene, part coding region.Derive from the human DNA sequence on the chromosome 22 q13 of PAC 408N23.Contain HIP, HSC70-interaction protein (PgR be correlated with P48 albumen), EST and STS.The zone 43/87 of Treponoma palladium complete genome group.Derive from human DNA sequence on the chromosome 22 q13 of PAC 408N23, contain HIP, HSC70-interaction protein (PgR be correlated with P48 albumen), EST and STS.	Brasil diazotrophic spirillum (Azospirillum brasilense) people Treponoma palladium (Treponema pallidum) people	60,613 34,567 37,564 34,911	99-06-07 99-11-23 98-07-16 99-11-23
									Rxa01151	958	GB_BA1:MTCY261 GB_HTG4:AC009849 GB_HTG4:AC009849	27,322 114,993 114993	Z97559 AC009849 AC009849	Mycobacterium tuberculosis H37Rv complete genome group; Section 95/162.No. 2 karyomit(e) clones of drosophila melanogaster BACR07H08 (D864) RPCI-98 07.H.8 map 31B-31C strain y; Cn bw sp, * *It is in progress to check order * *, 55 non-sequential segments.No. 2 karyomit(e) clones of drosophila melanogaster BACR07H08 (D864) RPCI-98 07.H.8 map 31B-31C strain y; Cn bw sp, * *It is in progress to check order * *, 55 non-sequential segments.	Mycobacterium tuberculosis drosophila melanogaster drosophila melanogaster	38,789 39,213 39,213	98-06-17 1999-10-25 1999-10-25
Rxa01161	1260	GB_BA2:AF176799 GB_BA2:AF012084 GB_EST32:A1728955	2,943 3,082 611	AF176799 AF012084 AI728955	Lactobacillus pentosus PepQ (pepQ) and katabolism control albumin A (ccpA) gene, complete coding region.Lactobacterium helveticus prolidase (pepQ) gene, complete coding region BNLGHi121146 days cotton fiber upland cotton cDNA5 ' are similar to the permease [Arabidopis thaliana] that (AC004481) infers, the mRNA sequence.	Lactobacillus pentosus (Lactobacillus pentosus) lactobacterium helveticus (Lactobacillus helveticus) upland cotton (Gossypium hirsutum)	37,043 46,796 37,647	99-09-05 98-07-01 99-06-11
									Rxa01181	980	GB_BA1:MLCB22 GB_BA1:MTCY190 GB_BA1:SC5F7	40,281 34,150 40024	Z98741 Z70283 AL096872	Mycobacterium leprae clay B22.Mycobacterium tuberculosis H37Rv complete genome group; Section 98/162.Streptomyces coelicolor clay 5F7.	Mycobacterium leprae mycobacterium tuberculosis streptomyces coelicolor A3 (2)	61,570 60,434 57,011	97-08-22 98-06-17 99-07-22
Rxa01182	516	GB_HTG1:CEY116A8-GB_HTG1:CEY116A8-GB_IN1:CEY116A8C	2,110,000 2,110,000 260341	Z98858 Z98858 AL117204	Caenorhabditis elegans IV karyomit(e) clone Y116A8, * *It is in progress to check order * *, be non-sequential segments.Caenorhabditis elegans IV karyomit(e) clone Y116A8, * *It is in progress to check order * *, be non-sequential segments.Caenorhabditis elegans clay Y116A8C, complete sequence.	Caenorhabditis elegans Caenorhabditis elegans Caenorhabditis elegans	34,843 34,843 34,843	99-10-26 99-10-26 99-11-19
									Rxa01189	732	GB_BA1:D90915 GB_BA1:D90915	130,001 130001	D90915 D90915	Synechocystis sp.PCC6803 complete genome group, 17/27,2137259-2267259.Synechocystis sp.PCC6803 complete genome group, 17/27,2137259-2267259.	Synechocystis?sp. Synechocystis?sp.?	36,538 34,512?	99-02-07 99-02-07?

Table 4 (continuing)

		GB_HTG3:AC010515	41038	AC010515	No. 19 karyomit(e) clones of people LLNL-R_249H9, * *It is in progress to check order * *, 31 non-sequential segments.	The people	33,564	99-09-15
									Rxa01192	681	GB_OM:CFP180RRC GB_OM:CFP180RRC	5,425 5425	X87224 X87224	The mRNA of domesticated dog ribosome receptor, the mRNA of p180 domesticated dog ribosome receptor, p180	Domesticated dog (Canis familiaris) domesticated dog	41,229 38,187	99-01-22 99-01-22
Rxa01214	1614	GB_IN1:CEY47D3A GB_PR4:AC006039 GB_PR4:AC006039	199,814 176,257 176257	AL117202 AC006039 AC006039	Caenorhabditis elegans clay Y47D3A, complete sequence.The people clones NH0319F03, complete sequence.The people clones NH0319F03, complete sequence.	Caenorhabditis elegans everybody	36,604 34,984 35,951	99-011-19 1999-05-05 1999-05-05
									Rxa01224	1146	GB_EST22:A1070047 GB_RO:S75965 GB_EST5:H96951	479 625 459	AI070047 S75965 H96951	UI-R-C1-In-f-08-0-UI.s1 UI-R-C1 brown rat cDNA clone U1-R-C1-In-f-08-0-UI 3 ', the mRNA sequence.THP=Tamm-Horsfall albumen { promotor } [rat, genome, 625nt].Yu01g03.r1 Soares_pineal_gland_N3HPG people cDNA clones IMAGE:2325645 ', mRNA sequence.	Brown rat (Rattus norvegicus) mouse (Rattrus sp.) people	36,975 34,400 32,969	99-07-05 95-07-27 1995-12-11
Rxa01250	588	GB-PL1:NEULCCB GB_OV:MTRACOMP L GB_OV:AF090339	2,656 16,714 16704	M18334 Y16884 AF090339	Coarse arteries and veins spore mould (bacterial strain TS) laccase gene, complete coding region.The complete Mitochondrial Genome Overview of Rhea americana.The complete Mitochondrial Genome Overview of Rhea americana.	Coarse arteries and veins spore mould (Neurospora crassa) Mitochondroin Rhea americana Mitochondroin Rhea americana	44,330 35,094 35,094	1994-05-03 99-07-19 1999-05-27
									Rxa01277	2127	GB_PL2:AF111709 GB_IN1:CELZC250 GB_EST1:Z14808	52,684 34,372 331	AF111709 AF003383 Z14808	Oryza sativa subsp.indica Retrosat 1 retrotransposon and Ty3-Gypsy type Retrosat 2 retrotransposons, complete sequence; And unknown gene.Caenorhabditis elegans clay ZC250.The cDNA library Caenorhabditis elegans cDNA clone cm5e4 5 ' of CEL5E4 Chris Martin classification, the mNRA sequence.	Oryza sativa subsp.indica Caenorhabditis elegans Caenorhabditis elegans	37,410 35,506 36,890	99-04-26 1997-05-14 97-06-19
Rxa01302	576	GB_BA1:MTCI65 GB_BA1:MSGY348 GB_BA1:SC5C7	34,331 40,056 41906	Z95584 AD000020 AL031515	Mycobacterium tuberculosis H37Rv complete genome group; Section 50/162.Derive from the mycobacterium tuberculosis sequence of clone y348.Streptomyces coelicolor clay 5C7.	Mycobacterium tuberculosis mycobacterium tuberculosis streptomyces coelicolor	59,298 59,227 39,261	98-06-17 1996-12-10 98-09-07
									Rxa01303	1458	GB_BA1:TTAJ5043 GB_PL2:AC010675 GB_GSS9:AQ170862	837 84,723 518	AJ225043 AC010675 AQ170862	Thermus thermophilus part nark gene.Arabidopis thaliana I karyomit(e) BAC T17F3 genome sequence, complete sequence.Human genome sperm library D people's gene group clone flat board=3165 row=6 row=L of HS 3165 B2 F03 T7 CIT approval, genome summary sequence.	Thermus thermophilus Arabidopis thaliana people	55,245 37,058 38,610	98-06-18 99-11-11 1998-10-17
Rxa01308	2503	GB_BA1:D90757 GB_BA1:D90787 GB_BA1:D90758	17,621 15,942 13860	D90757 D90787 D90758	Bacillus coli gene group DNA.(27.3-27.7 minute).Bacillus coli gene group DNA, Kohara clones #276 (33.0-33.3 minute).Bacillus coli gene group DNA.(27.6-27.9 minute).	The esherichia coli intestinal bacteria	55,445 36,815 54,942	99-02-07 1997-05-29 99-02-07
									Rxa01309	824	GB_BA1:SCJ12 GB_BA1:BSNARYWI	35,302 12450	AL109989 Z49884	Streptomyces coelicolor clay J12.Bacillus subtilus nar[G, L, J, K], ywi[C, D, E] and argS gene.	Streptomyces coelicolor A3 (2) Bacillus subtilus	62,423 57,447	99-08-24 98-06-24

Table 4 (continuing)

		GB_BA1:BSUB0020	212150	Z99123	Bacillus subtilus complete genome group (zone 20/21): 3798401-4010550.	Bacillus subtilus	37,129	97-11-26
									Rxa01358	1644	GB_GSS11:AQ260413 GB_EST20:AA840582 GB_PAT:A39944	453 326 3836	AQ260413 AA840582 A39944	CTTB1-E1-2510B12.TF CTTB1-E1 people's gene group clone 2510B12, genome summary sequence.Vw77h07.r1 Stratagene mouse heart (#937316) house mouse cDNA clones IMAGE:1261021 5 ', is similar to gb:J04181 mouse A-X Actin muscle mRNA, complete coding region (mouse); The mRNA sequence.Derive from the sequence 1 of patent WO9421807.	The people house mouse is unidentified	41,531 42,901 38,764	1998-10-24 98-02-27 1997-03-05
Rxa01385	2004	GB_BA1:FVBPENTA GB_PAT:I19994 GB_BA2:AF059680	2,519 2,516 2410	M98557 I19994 AF059680	Flavobacterium pentachlorophenol 4-monooxygenase gene, complete mRNA.Derive from the sequence 2 of patent US 5512478.Sphingol single-cell UG30 pentachlorophenol 4-monooxygenase (pcpB) gene, complete coding region; With pentachlorophenol 4-monooxygenase reductase enzyme (pcpD) gene, part coding region.	Sphingol single-cell (Sphingomonas sp.) UG30 that Flavobacterium (Flavobacterium sp.) is unknown	40,855 40,855 42,993	93-04-26 1996-10-07 99-04-27
									Rxa01412	327	GB_GSS12:AQ332469 GB_EST27:AA998532 GB_HTG1:HSA342D1 1	459 453 178183	AQ332469 AA998532 AL121748	HS_5003_A1_H08_SP6E RPCI11 human male BAC library people's gene group clone flat board=579 row=15 row=O, genome summary sequence.UI-R-C0-ic-d-11-0-UI.s1 UI-R-C0 brown rat cDNA clone UI-R-C0-ic-d-11-0-UI 3 ', the mRNA sequence.No. 10 karyomit(e) clones of people RP11-342D11, * *It is in progress to check order * *, be non-sequential segments.	People brown rat people	38,208 39,336 40,550	1999-03-06 1999-03-09 99-11-23
Rxa01458	1173	GB_BA2:AE000745 GB_BA2:AE000745	15,085 15085	AE000745 AE000745	The zone 77/109 of Aquifex aeolicus complete genome group.The zone 77/109 of Aquifex aeolicus complete genome group.	Aquifex aeolicus Aquifex aeolicas	37,694 35,567	1998-03-25 1998-03-25
									Rxa01571	723	GB_BA1:AB011413 GB_BA1:AB011413	12,070 12070	AB011413 AB011413	The gene of streptomyces griseus Off2, Orf3, Off4, Orf5, AfsA, Orf8, part and complete coding region.The gene of streptomyces griseus Orf2, Off3, Orf4, Orf5, AfsA, Orf8, part and complete coding region.	Streptomyces griseus (Streptomyces griseus) streptomyces griseus	57,500 35,655	98-08-07 98-08-07
Rxa01607	753	GB_PR4:AC005005 GB_HTG3:AC008257 GB-HTG3:AC008257	133,893 109,187 109187	AC005005 AC008257 AC008257	Derive from people's pac clone DJ412A9 of 22, complete sequence.No. 2 karyomit(e) clones of drosophila melanogaster BACR08A11 (D916) RPCI-98 08.A.11 map 42A-42A strain y; Cn bw sp, * *It is in progress to check order * *, 93 non-sequential segments.No. 2 karyomit(e) clones of drosophila melanogaster BACR08A11 (D916) RPCI-98 08.A.11 map 42A-42A strain y; Cn bw sp * *It is in progress to check order * *, 93 non-sequential segments.	People's drosophila melanogaster drosophila melanogaster	38,399 33,741 33,741	1999-03-02 1999-10-08 1999-10-08
									Rxa01609	996	GB_BA1:MTV003 GB_BA1:MSGB1529C S GB_BA1:AB024601	13,246 36,985 14807	AL008883 L78824 AB024601	Mycobacterium tuberculosis H37Rv complete genome group; Section 125/162.Mycobacterium leprae clay B1529 dna sequence dna.Pseudomonas aeruginosa tetrahydrochysene 2, the dapD gene of dipicolimic acid 2 N-succinyl transferring enzyme, complete coding region, bacterial strain PAO1.	Mycobacterium tuberculosis Mycobacterium leprae Pseudomonas aeruginosa (Pseudomonas aeruginosa)	39,369 60,624 41,603	98-06-17 96-06-15 1999-03-12

Table 4 (continuing)

Rxa01654	1119	GB_GSS4:AQ704352 GB_RO:MMAE000663 GB_EST23:AI158428	532 250,611 511	AQ704352 AE000663 AI158428	Human genome sperm library D people's gene group clone flat board=2147 row=8 row=O of HS_2147_A2_H04_MR CTT approval, genome summary sequence.House mouse TCR β locus, the base 1-250611 of described complete sequence (zone 1/3).Ud24f12.f1 Soares 2NbMT house mouse cDNA clones IMAGE:1446863 5 ', mRNA sequence.	People house mouse house mouse	37,838 35,799 41,337	99-07-07 97-09-04 98-09-30
									Rxa01664	945	GB_OV:AF026198 GB_PR3:AC004466 GB_PR3:AC004466	63,155 122,186 122186	AF026198 AC004466 AC004466	Fugu rubripes N-CAM L1 homologue (L1-CAM) gene, complete coding region; Albumen 1 (PUT1) gene of inferring, the part coding region; Mitotic division specific stain body protein isolate SMC1 homologue (SMC1) gene, the part coding region; With the calcium channel α-1 subunit homologue (CCAl) and albumen 2 (PUT2) gene of inferring, part coding region, complete sequence.People 12q13.1 PAC RPCI5-1057I20 (the human PAC of Roswell Park Cancer Institute library) complete sequence.People 12ql3.1 PAC RPCI5-1057120 (the human PAC of Roswell Park Cancer Institute library) complete sequence.	Fugu rubripes everybody	35,187 37,382 37,325	1998-05-02 98-09-17 98-09-17
Rxa01795	720	GB_BA2:CGU13922 GB_BA1:S86113 GB_PAT:I22080	4,412 1,044 850	U13922 S86113 I22080	II type 5-cytosine(Cyt) methyltransgerase (cgIIM) that Corynebacterium glutamicum is inferred and the II type restriction endonuclease (cgIIR) of inferring and the I type of inferring or III type restriction endonuclease (clgIIR) gene, complete coding region.The ORF1[Diplococcus gonorrhoeae, genome, 1044nt].Derive from the sequence 1 of patent US 5525717.	Corynebacterium glutamicum Diplococcus gonorrhoeae (Neisseria gonorrhoeae) the unknown	99,444 58,320 57,722	98-02-03 1993-05-07 1996-10-07
									Rxa01802	954	GB_BA2:AE001519 GB_GSS5:AQ774071 GB_PR4:AC007459	14,062 552 40907	AE001519 AQ774071 AC007459	The zone 80/132 of helicobacter pylorus bacteria strain J99 complete genome group.Human genome sperm library D people's gene group clone flat board=2269 row=19 row=F of HS_2269_B1_C10_T7C CIT approval, genome summary sequence.No. 16 karyomit(e) clones of people 306C6, complete sequence.	Helicobacter pylori (Helicobacter pylori) J99 everybody	33,510 37,967 39,140	99-01-20 99-07-29 1999-05-04
Rxa01838	842	GB_BA1:SCE15 GB_HTG3:AC009545 GB_HTG3:AC009545	26,440 165,042 165042	AL049707 AC009545 AC009545	Streptomyces coelicolor clay E15.No. 11 karyomit(e) clones of people 131_J_04map 11, * *It is in progress to check order * *, 8 non-sequential segments.No. 11 karyomit(e) clones of people 131_J_04map 11, * *It is in progress to check order * *, 8 non-sequential segments.	Streptomyces coelicolor everybody	36,297 37,651 37,651	99-04-22 1999-10-01 1999-10-01
									Rxa01848	867	GB_BA1:MTCY24A1 GB_EST21:C89252 GB_EST14:AA423340	20,270 587 457	Z95207 C89252 AA423340	Mycobacterium tuberculosis H37Rv complete genome group; Section 124/162.The early stage blastocyst cDNA of C89252 mouse house mouse cDNA clones 01B00061JC08, mRNA sequence.Ve39d04.r1 Soares mouse mammary gland NbMMG house mouse cDNA clones IMAGE:820519 5 ', mRNA sequence.	Mycobacterium tuberculosis house mouse house mouse	38,270 37,219 38,377	98-06-17 1998-05-28 1997-10-16

Table 4 (continuing)

Rxa01849	1224	GB_BA1:MTCY24A1 GB_BA2:RCPHSYNG GB_BA1:RSP010302	20,270 45,959 40707	Z95207 Z11165 AJ010302	Mycobacterium tuberculosis H37Rv complete genome group; Section 124/162.The complete photosynthesis gene cluster of the red bacterium of folder film.The red bacterial photosynthesis gene cluster of class ball.	The red bacterium of mycobacterium tuberculosis folder film red bacterium (Rhodobacter capsulatus) class ball	39,950 37,344 40,898	98-06-17 99-09-02 99-08-22
									Rxa01868	2049	GB_BA1:MTV033 GB_BA1:MLCL622 GB_BA1:MSGB983CS	21,620 42,498 36788	AL021928 Z95398 L78828	Mycobacterium tuberculosis H37Rv complete genome group; Section 11/162.Mycobacterium leprae clay L622.Mycobacterium leprae clay B983 dna sequence dna.	Mycobacterium tuberculosis Mycobacterium leprae Mycobacterium leprae	38,679 38,911 38,933	98-06-17 97-06-24 96-06-15
Rxa01885	924	GB_BA1:MTCY1A10 GB_PR3:HSU220B11 GB_BA1:PDU17435	25,949 41,247 993	Z95387 Z69908 U17435	Mycobacterium tuberculosis H37Rv complete genome group; Section 117/162.Derive from the human DNA sequence between the mark DXS6791 and DXS8038 on the X chromosome of clay cU220B11.Paracoccus denitrificans Fnr sample transcription activating protein (nnr) gene, complete coding region.	Mycobacterium tuberculosis people Paracoccus denitrificans (Paracoccus denitrificans)	51,094 39,038 39,390	98-06-17 99-11-23 95-07-19
									Rxa01914	526	GB_PR3:AC005796 GB_PR3:HS390C10 GB_PR3:AC005796	43,843 114,231 43843	AC005796 AL008721 AC005796	No. 19 karyomit(e)s of people, clay R31408, complete sequence.Derive from the human DNA sequence on the chromosome 22 q11.21-12.1 of BAC 390C10.Contain immunoglobulin-like gene and the pseudogene that is similar to the β crystallin.Contain EST, STS, GSS and taga and tat and repeat polymorphism, complete sequence.No. 19 karyomit(e)s of people, clay R31408, complete sequence.	The people everybody	34,961 39,600 37,725	1998-10-06 99-11-23 1998-10-06
Rxa01932	1020	GB_PR3:AC003025 GB_GSS3:B78728 GB_PR3:AC003025	112,309 312 112309	AC003025 B78728 AC003025	Human chromosomal 11p12.2PAC clones pDJ466a1l, complete sequence.CIT-HSP-431E3.TV CIT-HSP people's gene group clone 431E3, genome summary sequence.Human chromosomal 11p12.2PAC clones pDJ466a11, complete sequence.	The people everybody	35,585 38,907 35,859	98-07-23 98-06-25 98-07-23
									Rxa01933	726	GB_HTG1:HS74O16 GB_HTG1:HS74O16 GB_PR4:AC006032	169,401 169,401 170282	AL110119 AL110119 AC006032	No. 21 karyomit(e) clones of people RPCIP704O1674 map 21q21, * *It is in progress to check order * *, be non-sequential segments.No. 21 karyomit(e) clones of people RPCIP704O1674 map 21q21, * *It is in progress to check order * *, be non-sequential segments.Derive from the people BAC clone NH0115E20 of Y, complete sequence.	The people everybody	35,302 35,302 37,640	99-08-27 99-08-27 99-02-27
Rxa01971	954	GB_HTG3:AC008230 GB_HTG3:AC008230	108,469 108469	AC008230 AC008230	No. 2 karyomit(e) clones of drosophila melanogaster BACR17I17 (D934) RPCI-98 17.I.17 map 53A-53C strain y; Cn bw sp, * *It is in progress to check order * *, 108 non-sequential segments.No. 2 karyomit(e) clones of drosophila melanogaster BACR17I17 (D934) RPCI-98 17.I.17 map 53A-53C strain y; Cn bw sp, * *It is in progress to check order * *, 108 non-sequential segments.	The drosophila melanogaster drosophila melanogaster	35,466 35,466	99-08-10 99-08-10

Table 4 (continuing)

		GB_PR3:AF064860	165382	AF064860	Human chromosome 21q22.3 PAC 70I24, complete sequence.	The people	39,716	98-06-02
									Rxa02016	900	GB_EST2:D48846 GB_GSS10:AQ195886 GB_GSS10:AQ195886	459 595 595	D48846 AQ195886 AQ195886	The green seedling rice of RICS15292A paddy rice cDNA, the mRNA sequence.RPCI11-66O13.TJRPCI-11 people's gene group clone RPCI-11-66O13, genome summary sequence.RPCI11-66O13.TJRPCI-11 people's gene group clone RPCI-11-66O13, genome summary sequence.	Rice everybody	37,118 41,000 34,790	95-08-02 99-04-20 99-04-20
Rxa02017	807	GB_EST20:AA855266 GB_EST20:AA855266	406 406	AA855266 AA855266	Vw70b08.r1 Stratagene mouse heart (#937316) house mouse cDNA clones IMAGE:1260279 5 ', mRNA sequence.Vw70b08.r1 Stratagene mouse heart (#937316) house mouse cDNA clones IMAGE:1260279 5 ', mRNA sequence.	The house mouse house mouse	42,638 37,183	1998-03-06 1998-03-06
									Rxa02018	1073	GB_BA1:SC5C7 GB_BA1:MTCI65 GB_BA1:SCJ12	41,906 34,331 35302	AL031515 Z95584 AL109989	Streptomyces coelicolor clay 5C7.Mycobacterium tuberculosis H37Rv complete genome group; Section 50/162.Streptomyces coelicolor clay J12.	Streptomyces coelicolor mycobacterium tuberculosis streptomyces coelicolor A3 (2)	41,732 62,395 61,603	98-09-07 98-06-17 99-08-24
Rxa02048	1497	GB_PAT:E15823 GB_OM:SSAMPTDN GB_OV:D87992	2,323 3,387 3181	E15823 Z29522 D87992	Get the DNA of the Codocyte surface protein of self-produced ammonia rod bacillus.The mRNA of S.scrofa Aminopeptidase N.The mRNA of jungle fowl aminopeptidase Ey, complete coding region.	Produce ammonia rod bacillus (Corynebacterium ammoniagenes) Sus scrofa jungle fowl (Gallus gallus)	53,942 42,672 41,554	99-07-28 94-09-26 99-06-05
									Rxa02101	1386	GB_BA1:AP000064 GB_PL2:ATAC006587 GB_PL2:ATAC006587	247,695 79,262 79262	AP000064 AC006587 AC006587	Aeropyrum perix genomic dna, zone 7/7.Arabidopis thaliana II karyomit(e) BAC T17D12 genome sequence, complete sequence.Arabidopis thaliana II karyomit(e) BAC T17D12 genome sequence, complete sequence.	Aeropyrum pernix Arabidopis thaliana Arabidopis thaliana	39,882 38,490 34,863	99-06-22 1999-03-23 1999-03-23
Rxa02265	423	GB_BA2:AF120718 GB_PAT:E03531 GB_BA1:LBAAURE	4,137 2,896 2896	AF120718 E03531 D10605	Lactobacillus fermentum urase operon, partial sequence.The dna sequence dna of coding acid urease.The gene of lactobacillus fermentum acid urease.	Lactobacillus fermentum (Lactobacillus fernentum) lactobacillus fermentum lactobacillus fermentum	56,265 56,265 56,265	1999-03-31 97-09-29 99-02-02
									Rxa02276	801	GB_GSS10:AQ242920 GB-IN1:SLMMTPMF GB_IN2:AF012249	451 14,503 5542	AQ242920 D29637 AF012249	Human genome sperm library D people's gene group clone flat board=2061 row=15 row=I of HS_2061_A1_E08_MR CIT approval, genome summary sequence.Bull suede bubble bacterium Mitochondrial DNA.Derive from the bull suede bubble bacteria strain plastosome aux2-S district of mF plasmid, comprise URFA ', URFC, URFD, URFE, URFF and URFG gene, complete coding region and URFH gene, part coding region.	People bull suede bubble bacterium plastosome (Mitochondrion Physarum polycephalum) bull suede bubble bacterium plastosome	37,916 40,335 40,335	1998-10-03 1999-05-12 1998-05-08
Rxa02277	738	GB_BA2:AF048784	681	AF048784	Actinomyces naeslundii urase accessory protein (ureG) gene, complete coding region.	Actinomyces naeslundii (Actinomyces naeslundii)	66,814	99-02-09

Table 4 (continuing)

		GB_BA2:AF056321 GB_BA2:SSU35248	5,482 5773	AF056321 U35248	Actinomyces naeslundii urase γ subunit UreA (ureA), urase β subunit UreB (ureB), urase α subunit UreC (ureC), urase accessory protein UreE (ureE), urase accessory protein UreF (ureF), urase accessory protein UreG (ureG) and urase accessory protein UreD (ureD) gene, complete coding region.Streptococcus-salivarius ure bunch of nickel translocator homologue (ureI) gene, the part coding region, with urase β subunit (ureA), γ subunit (ureB), α subunit (ureC) and accessory protein (ureE), (ureF), (ureG) and (ureD) gene, complete coding region.	Actinomyces naeslundii streptococcus-salivarius (Streptococcus salivarius)	63,686 61,931	99-02-09 96-01-26
									Rxa02278	972	GB_GSS3:B49054 GB_PL1:PMCMSGI GB_PL2:AF038556	543 3,363 12792	B49054 L27092 AF038556	RPCI11-4I13.TV RPCI-11 people's gene group clone RPCI-11-4I13, genome summary sequence.Pneumocystis carinii B-cell receptor (msgI) gene, 3 ' end.Pneumocystis carinii people the cause a disease main surface glycoprotein of mutation (msg1, msg3, the msg4) region of variability of gene, part coding region.	People Pneumocystis carinii (Pneumocystis carinii) the Pneumocystis carinii people mutation (Pneumocystis carinii f.sp.hominis) of causing a disease	39,161 39,819 33,832	99-04-08 94-09-26 98-09-10
Rxa02317	735	GB_GSS8:AQ051031 GB_GSS8:AQ051031	914 914	AQ051031 AQ051031	Nbxb0004dG10r CUGI paddy rice BAC library rice genomic clone nbxb0004N20r, genome summary sequence.Nbxb0004dG10r CUGI paddy rice BAC library rice genomic clone nbxb0004N20r, genome summary sequence.	The rice rice	32,299 34,573	1999-03-24 1999-03-24
									Rxa02334	746	GB_BA1:CGU35023 GB_BA1:MTCY71 GB_BA1:U00012	3,195 42,729 33312	U35023 Z92771 U00012	Corynebacterium glutamicum thiosulfate transsulfurase (thtR) gene, part coding region, acyl-CoA carboxylase (accBC) gene, complete coding region.Mycobacterium tuberculosis H37Rv complete genome group; Section 141/162.Mycobacterium leprae clay B1308.	Corynebacterium glutamicum mycobacterium tuberculosis Mycobacterium leprae	100,000 60,380 37,660	97-01-16 99-02-10 96-01-30
Rxa02351	1039	GB_HTG2:HS225E12 GB_HTG2:HS225E12 GB_HTG2:HS225E12	126,464 126,464 126464	AL031772 AL031772 AL031772	No. 6 karyomit(e) clones of people RP1-225E12 map q24, * *It is in progress to check order * *, be non-sequential segments.No. 6 karyomit(e) clones of people RP1-225E12 map q24, * *It is in progress to check order * *, be non-sequential segments.No. 6 karyomit(e) clones of people RP1-225E12 map q24, * *It is in progress to check order * *, be non-sequential segments.	The people everybody	35,973 35,973 36,992	1999-12-03 1999-12-03 1999-12-03
									Rxa02410	789	GB_BA1:AB020624 GB_EST4:H51527 GB_GSS1:CNS003CM	1,605 294 1101	AB020624 H51527 AL064136	The murI gene of Corynebacterium glutamicum D-glutamate racemase, complete coding region.Yo33b09.s1 Soares Adult Human Brain N2b4HB55Y people cDNA clones IMAGE:179705 3 ', mRNA sequence.The drosophila melanogaster genome summary sequence T7 of the BAC #BACR08C19 in the RPCI-98 library of drosophila melanogaster (fruit bat) does not hold genome summary sequence.	Corynebacterium glutamicum people drosophila melanogaster	99,227 40,411 37,674	99-07-24 95-09-18 99-06-03

Table 4 (continuing)

Rxa02477	744	GB_HTG4:AC010054 GB_HTG4:AC010054 GB_HTG4:AC009375	130,191 130,191 137069	AC010054 AC010054 AC009375	Drosophila melanogaster chromosome 3L/74E2 clones RPCI98-15E10, * *It is in progress to check order * *, 70 non-sequential segments.Drosophila melanogaster chromosome 3L/74E2 clones RPCI98-15E10, * *It is in progress to check order * *, 70 non-sequential segments.Drosophila melanogaster chromosome 3L/75A1 clones RPCI98-44L18, * *It is in progress to check order * *, 59 non-sequential segments.	Drosophila melanogaster drosophila melanogaster drosophila melanogaster	37,466 37,466 39,118	1999-10-16 1999-10-16 1999-10-16
									Rxa02513	832	GB_BA1:MTER260 GB_PL1:AB019229 GB_PL1:AB019229	373 84,294 84294	X92572 AB019229 AB019229	The proteic gene of mycobacterium terrae 32kDa (part).Arabidopsis thaliana genomic dna, No. 3 karyomit(e)s, P1 clone: MDC16, complete sequence.Arabidopsis thaliana genomic dna, No. 3 karyomit(e)s, P1 clone: MDC16, complete sequence.	Mycobacterium terrae (Mycobacterium terrae) Arabidopis thaliana Arabidopis thaliana	42,895 36,084 35,244	98-01-15 99-11-20 99-11-20
Rxa02531	834	GB_BA1:CGLATTB GB_EST11:AA239557 GB_BA1:RSPYPPCL	271 423 6500	X89850 AA239557 AL002398	The DNA in Corynebacterium glutamicum attB district.The 0th day house mouse cDNA clone of mv25f04.r1 GuayWoodford Beier mouse kidney IMAGE:656095 5 ' is similar to the proteic tlm oncogene of gb:X52634 muroid tlm (mouse); The mRNA sequence.Red bacterium pyp of class ball and pcl gene and offA, orfB, orfC, orfD, orfE, orfF.	The red bacterium of Corynebacterium glutamicum house mouse class ball	40,590 38,760 37,091	96-08-08 1997-03-12 1998-12-17
									Rxa02548	314	GB_BA2:AF127374	63734	AF127374	Lilac grey streptomycete LinA homologue, Cytochrome P450 hydroxylase ORF4, Cytochrome P450 hydroxylase ORF3, MitT (mitT), MitS (mitS), MitR (mitR), mitQ (mitQ), MitP (mitP), MitO (mitO), MitN (mitN), MitM (mitM), MitL (mitL), MitK (mitK), MitJ (mitJ), MitI (mitI), MitH (mitH), MitG (mitG), MitF (mitF), MitE (mitE), MitD (mitD), MitC (mitC), MitB (mitB), MitA (mitA), MmcA (mmcA), MmcB (mmcB), MmcC (mmcC), MmcD (mmcD), MmcE (mmcE), MmcF (mmcF), MmcG (mmcG), MmcH (mmcH), MmcI (mmcI), MmcJ (mmcJ), MmcK (mmcK), MmcL (mmcL), MmcM (mmcM), MmcN (mmcN), MmcO (mmcO), Mid (mrd), MmcP (mmcP), MmcQ (mmcQ), MmcR (mmcR), MmcS (mmcS), MmcT (mmcT), MmcU (mmcU), MmcV (mmcV), Mct (mct), MmcW (mmcW), MmcX (mmcX) and MmcY (mmcY) gene, complete coding region; And unknown gene.	Lilac grey streptomycete (Streptomyces lavendulae)	66,242	1999-05-27

Table 4 (continuing)

		GB_BA2:AF127374 GB_GSS4:AQ741886	63,734 742	AF127374 AQ741886	Lilac grey streptomycete LinA homologue, Cytochrome P450 hydroxylase ORF4, Cytochrome P450 hydroxylase ORF3, MitT (mitT), MitS (mitS), MitR (mitR), mitQ (mitQ), MitP (mitP), MitO (mitO), MitN (mitN), MitM (mitM), MitL (mitL), MitK (mitK), MitJ (mitJ), MitI (mitI), MitH (mitH), MitG (mitG), MitF (mitF), MitE (mitE), MitD (mitD), MitC (mitC), MitB (mitB), MitA (mitA), MmcA (mmcA), MmcB (mmcB), MmcC (mmcC), MmcD (mmcD), MmcE (mmcE), MmcF (mmcF), MmcG (mmcG), MmcH (mmcH), MmcI (mmcI), MmcJ (mmcJ), MmcK (mmcK), MmcL (mmcL), MmcM (mmcM), MmcN (mmcN), MmcO (mmcO), Mrd (mrd), MmcP (mmcP), MmcQ (mmcQ), MmcR (mmcR), MmcS (mmcS), MmcT (mmcT), MmcU (mmcU), MmcV (mmcV), Mct (mct), MmcW (mmcW), MmcX (mmcX) and MmcY (mmcY) gene, complete coding region; And unknown gene.HS_5569_B2_B02_SP6R_PCI-11 human male BAC library people's gene group clone flat board=1145 row=4 row=D, genome summary sequence.	Lilac grey streptomycete people	38,411 38,907	1999-05-27 99-07-16
									Rxa02558	1098	GB_EST18:AA567307 GB_EST27:AI402394 GB_GSS 10:AQ237646	741 630 715	AA567307 AI402394 AQ237646	HL01004.5prime HL drosophila melanogaster head BlueScript drosophila melanogaster cDNA clone HL01004 5prime, the mRNA sequence.GH21610.5prime GH drosophila melanogaster head pOT2 drosophila melanogaster cDNA clone GH21610 5prime, the mRNA sequence.RPCI11-61I9.TJB RPCI-11 people's gene group clone RPCI-11-61I9, genome summary sequence.	Drosophila melanogaster drosophila melanogaster people	38,736 41,308 44,340	98-11-28 99-02-08 99-04-21
Rxa02565	1389	GB_EST32:AI726448 GB_EST32:AI726198 GB_PR4:AC002992	562 608 154848	AI726448 AI726198 AC002992	6 days cotton fiber upland cotton of BNLGHi5854 cDNA5 ' is similar to (U53418) UDP-Hexose phosphate dehydrogenase [soybean], the mRNA sequence.6 days cotton fiber upland cotton of BNLGHi5243 cDNA5 ' is similar to (U53418) UDP-Hexose phosphate dehydrogenase [soybean], the mRNA sequence.People's Y chromosome, clone 203M13, complete sequence.	Upland cotton upland cotton people	37,003 40,925 38,039	99-06-11 99-06-11 1999-10-13
									Rxa02574	1311	GB_EST4:H29653 GB_PR3:HSDJ261K5	415 131974	H29653 AL050350	Ym58f01.r1 Soares baby brain 1NIB people cDNA clones IMAGE:526785 ', is similar to SP:OXDD BOVIN P31228 D-aspartate oxidase; The mRNA sequence.Derive from the human DNA sequence of the karyomit(e) 6q21-22.1 of clone 261K5.Contain novel organic cation transporter gene (BAC ORF RG331P03) 3 ' partly, DDO gene, EST, STS, GSS and two CpG islands of inferring of D-aspartate oxidase (EC 1.4.3.1), complete sequence.	Everybody	39,036 35,957	95-07-17 99-11-23

Table 4 (continuing)

		GB_EST2:R20147	494	R20147	Yg18h02.r1 Soares baby brain 1NIB people cDNA clones IMAGE:32866 5 ', is similar to SP:OXDD_BOVIN P31228 D-aspartate oxidase; The mRNA sequence.	The people	36,437	95-04-17
									Rxa02589	888	GB_HTG1:CEY6E2 GB_HTG1:CEY6E2 GB_HTG3:AC011690	186,306 186,306 72277	Z96799 Z96799 AC011690	Caenorhabditis elegans V karyomit(e) clone Y6E2, * *It is in progress to check order * *, be non-sequential segments.Caenorhabditis elegans V karyomit(e) clone Y6E2, * *It is in progress to check order * *, be non-sequential segments.The people clones 17_E_13, low pass sequential sampling (LOW-PASS SEQUENCE SAMPLING).	Caenorhabditis elegans Caenorhabditis elegans people	37,979 37,979 35,814	1997-10-02 1997-10-02 1999-10-10
Rxa02592	894	GB_BA1:MSGB983CS GB_GSS9:AQ170723 GB_GSS12:AQ349397	36,788 487 791	L78828 AQ170723 AQ349397	Mycobacterium leprae clay B983 dna sequence dna.Human genome sperm library D people's gene group clone flat board=2270 row=10 row=L of HS_2270_B2_F05_MR CIT approval, genome summary sequence.RPCI11-118H16.TJ RPCI-11 people's gene group clone RPCI-11-118H16, genome summary sequence.	Mycobacterium leprae everybody	53,235 39,666 34,204	96-06-15 1998-10-16 1999-05-07
									Rxa02603	1119	GB_BA1:MTV026 GB_IN2:AC005714 GB_EST19:AA775050	23,740 177,740 218	AL022076 AC005714 AA775050	Mycobacterium tuberculosis H37Rv complete genome group; Section 157/162.Drosophila melanogaster, 2R karyomit(e), regional 58D4-58E2, BAC clones BACR48M13, complete sequence.Ac76e10.s1 Stratagene lung (#937210) people cDNA clones IMAGE:868554 3 ', is similar to gb:Y00371_mal heat shock homologue (cognate) 71KD albumen (mankind); The mRNA sequence.	Mycobacterium tuberculosis drosophila melanogaster people	37,975 41,226 40,826	99-06-24 1999-05-01 98-02-05
Rxa02630	1446	GB_BA1:MLCL373 GB_BA1:MTV044 GB_BA1:MLU15180	37,304 16,150 38675	AL035500 AL021999 U15180	Mycobacterium leprae clay L373.Mycobacterium tuberculosis H37Rv complete genome group; Section 45/162.Mycobacterium leprae clay B1756.	Mycobacterium leprae mycobacterium tuberculosis Mycobacterium leprae	49,015 49,192 45,621	99-08-27 98-06-17 1995-03-09
									Rxa02643	1167	GB_EST37:AI950576 GB_EST37:AI950576	308 308	AI950576 AI950576	Wx52e08.x1 NCI_CGAP_Lu28 people cDNA clones IMAGE:2547302 3 ', mRNA sequence.Wx52e08.x1 NCI_CGAP_Lu28 people cDNA clones IMAGE:2547302 3 ', mRNA sequence.	Everybody	40,909 40,288	99-09-06 99-09-06
Rxa02644	774	GB_EST34:AV149547 GB_EST35:AV156221 GB_EST32:AV054919	302 271 274	AV149547 AV156221 AV054919	10-11 days embryo house mouses of AV149547 house mouse C57BL/6J cDNA clones 2810489D03, mRNA sequence.12 days embryo house mouses of AV156221 house mouse C57BL/6J cDNA clones 3000001C24, mRNA sequence.The adult house mouse cDNA clone of AV054919 house mouse pancreas C57BL/6J 1810033C08, the mRNA sequence.	House mouse house mouse house mouse	38,627 33,990 36,585	99-07-05 99-07-07 99-06-23
									Rxa02745	902	GB_BA1:MTV007	32806	AL021184	Mycobacterium tuberculosis H37Rv complete genome group; Section 64/162.	Mycobacterium tuberculosis	39,298	98-06-17

Table 4 (continuing)

		GB_BA2:AF027770 GB_BA2:SAU43537	30,683 3938	AF027770 U43537	M. smegmatics FxbA (fxbA) gene, the part coding region; FxbB (fxbB), FxbC (fxbC) and FxuD (fxtD) gene, complete coding region and unknown gene.Streptomyces argillaceus mithramycin RD, ATP conjugated protein (mtrA) and membranin (mtrB) gene, complete coding region.	M. smegmatics (Mycobacterium smegmatis) Streptomyces argillaceus	55,125 46,868	1998-12-03 96-09-05
									Rxa02746	290	GB_BA1:CAJ10319 GB_BA1:MTCY338 GB_HTG3:AC008733	5,368 29,372 216140	AJ010319 Z74697 AC008733	Corynebacterium glutamicum amtP, glnB, glnD gene and part ftsY and srp gene.Mycobacterium tuberculosis H37Rv complete genome group; Section 127/162.No. 19 karyomit(e) clones of people CITB-E1_2525J15, * *It is in progress to check order * *, 72 non-sequential segments.	Corynebacterium glutamicum mycobacterium tuberculosis people	100,000 39,785 35,688	1999-05-14 98-06-17 99-08-03
Rxa02820	1411	GB_BA1:BFU64514 GB_IN1:CET04C10 GB_EST35:AI823090	3,837 20,958 720	U64514 Z69885 AI823090	Bacillus firmus dppABC operon, two peptide transport protein dppA genes, part coding region and two peptide transport protein dppB and dppC gene, complete coding region.Caenorhabditis elegans clay T04C10, complete sequence.L30-944T3 Ice plant λ Uni-Zap XR expression library, NaCl handled Mesembryanthemum crystallinum cDNA clone L30-944 5 ' in 30 hours, was similar to 60S ribosomal protein L 36 (AC004684) [Arabidopis thaliana], the mRNA sequence.	Bacillus firmus (Bacillus firmus) Caenorhabditis elegans Mesembryanthemum crystallinum	36,859 35,934 35,770	97-02-01 99-09-02 99-07-21
									Rxa02834	518	GB_BA1:CJY13333 GB_BA2:AF065404 GB_PL2:AC006601	3,315 181,654 110684	Y13333 AF065404 AC006601	Campylobacter jejuni clpB gene Bacillus anthracis toxicity plasmid PX01, complete sequence.Near the Arabidopis thaliana V karyomit(e) 60.5cM collection of illustrative plates, complete sequence.	Campylobacter jejuni (Campylobacter jejuni) Bacillus anthracis (Bacillus anthracis) Arabidopis thaliana	53,400 45,168 36,680	99-04-12 1999-10-20 99-02-22

The embodiment part

Embodiment 1: the preparation of the total genomic dna of Corynebacterium glutamicum ATCC13032

Allow Corynebacterium glutamicum (ATCC 13032) culture under 30 ℃ in BHI substratum (Difco) the thermal agitation grow overnight.By centrifugal collecting cell, abandoning supernatant is resuspended in 5ml damping fluid I (all specified volumes of the 5%--of culture initial volume all calculate according to the 100ml culture volume) with cell.The composition of damping fluid I: 140.34g/l sucrose, 2.46g/l 、10ml/l? (100g/l uses solution Transfer to pH6.7), 50ml/l M12 enriched material (10g/l 、1g/l? 、2g/l? 、0.2g/l? , 0.5g/l yeast extract paste (Difco), 10ml/l trace element mixture (200mg/l 、10mg/l? 、3mg/l? 、30mg/l 、20mg/l? 、1mg/l? 、3mg/l? , 500mg/l complexing agent (EDTA or citric acid), 100ml/l vitamine mixture (0.2mg/l vitamin H, 0.2mg/l folic acid, 20mg/l para-amino benzoic acid, 20mg/l riboflavin, 40mg/l calcium pantothenate (ca-panthothenate), 140mg/l nicotinic acid, 40mg/l pyridoxine hydrochloride, 200mg/l inositol).N,O-Diacetylmuramidase is added in the suspension to final concentration 2.5mg/ml.After about 4 hours, cell walls is degraded, by the protoplastis that centrifugal results produced in 37 ℃ of incubations.Precipitation is with 5ml damping fluid I washing 1 time, with 5ml TE damping fluid (10mM Tris- , 1mMEDTA, pH 8) washing 1 time.Precipitation is resuspended in the 4ml TE damping fluid, adds 0.5mlSDS solution (10%) and 0.5ml Solution (5M).Add Proteinase K to final concentration 200 μ g/ml, with suspension in about 18 hours of 37 ℃ of incubations.Adopt standard method, by using phenol, phenol-chloroform-primary isoamyl alcohol and chloroform-primary isoamyl alcohol extracting, purify DNA.Then, by 3M sodium acetate and 2 volume ethanol that add 1/50 volume, then in-20 ℃ of incubations 30 minutes, in supercentrifuge with SS34 rotor (Sorvall) with 12, centrifugal 30 minutes of 000rpm precipitates described DNA.DNA is dissolved in the TE damping fluid that 1ml contains 20 μ g/ml RNA enzyme A, in 4 ℃ to 1000ml TE damping fluid dialysis at least 3 hours.During this period, exchange buffering liquid is 3 times.In the dna solution through dialysing of 0.4ml equal portions, add 0.4ml 2M With 0.8ml ethanol.After 30 minutes, collect DNA in-20 ℃ of incubations by centrifugal (13,000rpm, BiofugeFresco, Heraeus, Hanau, Germany).The DNA precipitation is dissolved in the TE damping fluid.DNA with this method preparation can be used for all purposes, comprises the structure of southern blotting technique method or genomic library.

Embodiment 2: make up the genomic library of Corynebacterium glutamicum ATCC13032 in intestinal bacteria

The DNA that adopts embodiment 1 described preparation according to known clear and definite method (referring to for example Sambrook, J. etc., (1989) " Molecular Cloning:A Laboratory Manual ", ColdSpring Harbor Laboratory Press, or Ausubel, F.M. etc. (1994) " CurrentProtocols in Molecular Biology ", John Wiley ﹠amp; Sons.) make up clay and plasmid library.

Can use any plasmid or clay.The concrete plasmid that uses is plasmid pBR322 (Sutcliffe, J.G. (1979) Proc.Natl.Acad.Sci.USA, 75:3737-3741), pACYC177 (Change ﹠amp; Cohen (1978) J.Bacteriol 134:1141-1156), pBS plasmid series (pBSSK+, pBSSK-and other series; Stratagene, LaJolla, USA) or clay such as SuperCosl (Stratagene, LaJolla, USA) or Lorist6 (Gibson, T.J., Rosenthal A. and Waterson, R.H. (1987) Gene 53:283-286).Use plasmid pSL109 can make up the gene library (Lee, H.-S. and A.J.Sinskey (1994) J.Microbiol.Biotechnol.4:256-263) that is used in particular for Corynebacterium glutamicum.

Embodiment 3:DNA order-checking and computing function analysis

The genomic library that Application Example 2 is described is according to standard method, especially utilize the chain termination method of ABI377 sequenator (referring to for example Fleischman, R.D. etc. (1995) " genome sequencing at random and assembling of hemophilus influenzae Rd. ", Science 269:496-512) carries out dna sequencing.Use has the sequencing primer of following nucleotide sequence: 5 '-GGAAACAGTATGACCATG-3 ' (SEQ ID NO:441) or 5 '-GTAAAACGACGGCCAGT-3 ' (SEQ ID NO:442).

Embodiment 4: mutagenesis in vivo

Plasmid (or other carrier) DNA is gone down to posterity by impaired intestinal bacteria or other microorganism (for example genus bacillus or yeast such as yeast saccharomyces cerevisiae) of ability that keeps its genetic information integrity, thus mutagenesis Corynebacterium glutamicum in vivo.The DNA repair system gene of typical case's mutator exists sudden change (for example mutHLS, mutD, mutT etc.; Reference is seen Rupp, and W.D. (1996) DNA repair mechanism is stated from: Escherichia coli and Salmonella, and the 2277-2294 page or leaf, ASM:Washington.).This class bacterial strain is that those skilled in the art are known.Greener for example, A. and Callahan have introduced the use of described bacterial strain among M. (1994) the Strategies 7:32-34.

Embodiment 5: the DNA between intestinal bacteria and the Corynebacterium glutamicum shifts

Some Corynebacteriums and brevibacterium sp bacterial classification contain self-replicating (summarizes referring to for example Martin J.F. etc. (1987) Biotechnology, endogenous plasmid 5:137-146) (for example pHM1519 or pBL1).Adopt the intestinal bacteria standard vector (Sambrook that wherein adds replication orgin and Corynebacterium glutamicum appropriate flags, J. etc. (1989), " Molecular Cloning:ALaboratory Manual ", Cold Spring Harbor Laboratory Press or Ausubel, F.M. etc. (1994) " Current Protocols in Molecular Biology ", John Wiley ﹠amp; Sons) can easily make up the shuttle vectors of intestinal bacteria and Corynebacterium glutamicum.Described replication orgin is preferably taken from the endogenous plasmid of separation from Corynebacterium and brevibacterium sp bacterial classification.The transformation marker of concrete these bacterial classifications that use is kalamycin resistance gene (for example kalamycin resistance gene of Tn5 or Tn903 transposon generation) or chloramphenicol resistance gene (Winnacker, E.L. (1987), From Genes to Clones-Introduction to Gene Technology, VCH, Weinheim).Enumerated many in the described document about making up the embodiment of various shuttle vectorss, described shuttle vectors can duplicate and can be used for some purposes in intestinal bacteria and Corynebacterium glutamicum, (reference is referring to for example Yoshihama to comprise gene overexpression, (1985) J.Bacteriol.162:591-597 such as M., (1987) Biotechnology such as Martin J.F., 5:137-146 and Eikmanns, B.J. etc. (1991) Gene, 102:93-98).

The application standard method can be cloned into goal gene a kind of above-mentioned shuttle vectors and this heterozygosis carrier is imported in the Corynebacterium glutamicum strain.Can adopt following method to transform Corynebacterium glutamicum: protoplast transformation (Kastsumata, (1984) J.Bacteriol.159306-311 such as R.), electroporation (Liebl, (1989) FEMS Microbiol.Letters such as E., 53:399-303), if use special carrier, also can adopt method of joining (seeing for example Sch_fer, A etc. (1990) J.Bacteriol.172:1663-1666).Be transformed into intestinal bacteria by preparation Corynebacterium glutamicum plasmid DNA (utilizing the known standard method in this area) and with it, also can make shuttle vectors transfer to intestinal bacteria from Corynebacterium glutamicum.Adopt standard method can carry out this step of converting, but preferably use Mcr defective escherichia coli bacterial strain such as NM522 (Gough and Murray (1983) J.Mol.Biol.166:1-19).

Can use and comprise pCG1 (U.S. Patent number 4,617,267) or its fragment and the optional TN903 kalamycin resistance gene (Grindley that comprises, N.D. and Joyce, C.M. (1980) Proc.Natl.Acad Sci.USA 77 (12): plasmid 7176-7180) is the overexpression range gene in Corynebacterium glutamicum strain.In addition, also can use plasmid pSL109 overexpression range gene (Lee, H.-S. and A.J.Sinskey (1994) J.Microbiol.Biotechnol.4:256-263) in Corynebacterium glutamicum strain.

Except using the rf plasmid, also can realize gene overexpression by being integrated into genome.Utilize known method can be implemented in genome conformity in Corynebacterium glutamicum or other Corynebacterium or the brevibacterium sp bacterial classification, for example with the integration (REMI) (referring to for example DE patent 19823834) of the homologous recombination in genome district, restriction endonuclease mediation or use transposon.The activity that also can take following measure to modify regulatory region (for example promotor, repressor and/or enhanser) and regulate goal gene: utilize fix-point method (for example homologous recombination) or carry out sequence modification, insertion or disappearance based on the method (for example transposon mutagenesis or REMI) of random occurrence.Also can insert the nucleotide sequence of transcription terminator effect at 3 ' of the one or more gene coding regions of the present invention; Described terminator is that this area is known, for example at Winnacker, E.L. (1987) FromGenes to Clones-Introduction to Gene Technology.VCH:Weinheim) in its introduction is arranged.

Embodiment 6: estimate the expression of mutain

Mutain activity in the observation transformed host cell depends on such fact: mutain reaches with similar scale in the mode similar to wild-type protein.The process useful of a kind of definite mutator gene transcriptional level (effectively translating the index of the mRNA amount of gene product) is to carry out the RNA trace (reference is for example seen (1988) Current Protocols inMolecular Biology such as Ausubel, Wiley: New York), wherein use the design primer of detectable label (being generally radioactivity or chemoluminescence) mark binding purposes gene, make as the total RNA that extracts described biological culture thing, electrophoresis on gel, be transferred on the stabilized matrix and during with described probe incubation, the combination of described probe and binding capacity can illustrate the existence of described gene and indicate the mRNA amount of this gene.Such information is the evidence that mutator gene is transcribed degree.Using the known method in some this areas can prepare total cell RNA from Corynebacterium glutamicum, Bormann for example, the method that E.R. etc. (1992) Mol.Microbiol.6:317-326 introduces.

Translate proteic existence or relative quantity in order to estimate described mRNA, can use standard technique for example western blotting (referring to (1988) Current Protocols inMolecular Biology such as for example Ausubel, Wiley: New York).In this process, extract total cell protein, separate through gel electrophoresis, be transferred to as on the matrix of nitrocellulose and the probe such as the antibody incubation that combine desirable proteins with specificity.This probe is general with the chemoluminescence or the colorimetric marker mark that detect easily.Observe that marker exists and the marker amount illustrates and has required mutain and amount thereof in the described cell.

Embodiment 7: cultivation-substratum of the Corynebacterium glutamicum of genetic improvement and culture condition

With synthetic or spontaneous growth culture medium culturing genetic improvement rod bacillus.The many different growth mediums that are used for excellent bacillus are well-known and easy acquisition (Lieb etc. (1989) Appl.Microbiol.Biotechnol., 32:205-210; (1998) Biotechnology Letters such as von der Osten, 11:11-16; Patent DE 4,120, and 867; Liebl (1992) " Corynebacterium " is stated from: The Procaryotes, and the II volume, Balows, A. etc. write, Springer-Verlag).The composition of these substratum is: one or more carbon sources, nitrogenous source, inorganic salt, VITAMIN and trace element.Preferred carbon source is that sugar is as monose, disaccharides or polysaccharide.For example glucose, fructose, seminose, semi-lactosi, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or Mierocrystalline cellulose are extraordinary carbon source.Also can provide sugar for substratum by other byproduct of complex chemical compound such as molasses or refined sugar.The mixture that different carbon sources are provided also may be useful.Other possible carbon source is alcohols and organic acid, for example methyl alcohol, ethanol, acetic acid or lactic acid.Nitrogenous source is generally the organic or inorganic nitrogen compound, perhaps contains the material of these compounds.Typical case's nitrogenous source comprises ammonia or ammonium salt, for example ammonium chloride or ammonium sulfate, ammonium hydroxide, nitrate, urea, amino acid or compound nitrogen source such as corn steep liquor, soyflour, soybean protein, yeast extract paste, meat extract etc.

The inorganic salt compound that substratum can contain comprises hydrochloride, phosphite or the vitriol of calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron.Can add chelate compound in the described substratum, to keep the solution metal ion.Especially effectively chelate compound comprises dihydric phenol (for example catechol or Protocatechuic Acid) or organic acid (for example citric acid).Described substratum also routine contains other somatomedin, for example VITAMIN or growth stimulant, and the example comprises vitamin H, riboflavin, VitB1, folic acid, nicotinic acid, pantothenate and pyridoxol.Somatomedin and salt are derived from the complex medium component usually, for example yeast extract paste, molasses, corn steep liquor etc.The definite composition of substratum compound and direct experiment is closely related and specifically depend on each particular case.Can be about the information of medium optimization at textbook " Applied Microbiol.Physiology; obtain among the A PracticalApproach (P.M.Rhodes, P.F.Stanbury writes, IRL Press (1997); 53-73 page or leaf, ISBN 0 19 963,577 3).Also can be from commercial Supplier Selection growth medium, for example standard No. 1 (Merck) or BHI (grain heart infusion, DIFCO) etc.

All nutrient media componentses are by heat sterilization (in 1.5 handkerchiefs and 121 ℃ 20 minutes) or filtration sterilization.Described component can be sterilized together, can sterilize respectively if desired.Just exist when all nutrient media componentses can be cultivated beginning, perhaps can choose wantonly continuously or adding in batches.

Each experiment separate provision culture condition.Temperature should be 15 ℃-45 ℃.Culture temperature can keep constant or experiment in change.The pH of substratum should be 5-8.5, preferred about 7.0, can add buffer reagent in substratum and keep pH.The typical buffer that is used for this purpose is a potassium phosphate buffer agent.Can select or use simultaneously synthetic buffer reagent such as MOPS, HEPES, ACES etc.Also can add sodium hydroxide or ammonium hydroxide in the training period and keep constant cultivation pH.If use complex medium component such as yeast extract paste, extra buffer reagent needs and may reduce, because in fact many complex chemical compounds have high surge capability.If use the described microorganism of fermentor cultivation, also can use ammonia control pH.

Incubation time is generally a few hours to a couple of days.Select incubation time so that liquid nutrient medium cumulative product amount is maximum.Available various container carries out disclosed growth experiment, for example the glass or the metal fermentor tank of microtiter plate, glass test tube, glass flask or different sizes.In order to screen a large amount of clones, culturing micro-organisms should be used microtiter plate, glass test tube or shake bottle (have or do not have baffle plate).The preferred 100ml that uses shakes bottle, and the growth medium that 10% (volume) needs wherein is housed.Culturing bottle should be gone up jolting at the rotary jolting device (amplitude is 25mm) that uses the 100-300rpm velocity range.Keeping moistening atmosphere makes the evaporation forfeiture minimum; Perhaps should carry out mathematics and proofread and correct vaporization losses.

If test genetically modified clone, also should test not modified contrast clone or contain and clone without any the contrast of inserting segmental basic plasmid.Utilize and go up the cell inoculation substratum of growth to OD in the agar plate such as the CM flat board (10g/l glucose, 2.5g/l sodium-chlor, 2g/l urea, the poly-peptone of 10g/l, 5g/l yeast extract paste, 5g/l meat extract, 22g/l sodium-chlor, 2g/l urea, the poly-peptone of 10g/l, 5g/l yeast extract paste, 5g/l meat extract, 22g/l agar, pH 6.8,2M sodium hydroxide) of 30 ℃ of incubations ₆₀₀Be 0.5-1.5.Add the salt aqeous suspension of the Corynebacterium glutamicum cell derive from the CM flat board or add the pre-culture of liquid of this bacterium, thereby finish culture medium inoculated.

Embodiment 8: the function of analyzed in vitro mutain

This area has clear and definite enzymic activity and kinetic parameter assay method.The ratio that must make the experiment of measuring any given change enzymic activity be fit to wild-type enzyme is lived, and this is fully in persons skilled in the art limit of power.Be found in for example following document: Dixon, M. and Webb, E.C., (1979) Enzymes, Longmans:London about the general general introduction of enzyme and the detail and the many enzyme assay examples that relate to structure, kinetics, principle, method, application; Fersht, (1985) Enzyme Structure and Mechanism, Freeman: New York; Walsh, (1979) Enzymatic Reaction Mechanisms.Freeman:San Francisco; Price, N.C., Stevens, L. (1982) Fundamentals of Enzymology.Oxford Univ.Press:Oxford; Boyer, P.D. write (1983) The Enzymes, the third edition, Academic Press: New York; Bisswanger, H., (1994) Enzymkinetik, second edition, VCH:Weinheim (ISBN 3527300325); Bergmeyer, H.U., Bergmeyer, J., Gra β 1, M. write (1983-1986) Methods of Enzymatic Analysis, the third edition, I-XII volume, VerlagChemie:Weinheim; And Ullmann ' s Encyclopedia of Industrial Chemistry (1987), A9 volume, " Enzymes ", VCH:Weinheim, 352-363 page or leaf.

Can use the displacement of several clear and definite methods such as DNA band and measure the protein-active of (being also referred to as gel blocking measures) mensuration in conjunction with DNA.Available reporter gene is measured (Kolmar for example, H. etc. (1995) EMBO J.14:3895-3904 and the mensuration introduced of citing document wherein) and is measured the influence of described albumen to other developed by molecule.The reporter gene test macro is well-known and clearly is used for prokaryote and eukaryotic cells, utilizes enzyme such as beta galactosidase enzyme, green fluorescent protein etc.

According to for example Gennis, R.B. (1989) " fenestra, passage and translocator ", be stated from: Biomembranes, Molecular Structure and Function, Spfinger:Heidelberg, the technology of 85-137,199-234 and the introduction of 270-322 page or leaf can be measured the activity of protein called membrane transporters.

Embodiment 9: analyze the influence of mutain to required product output

Can followingly estimate the influence of the heredity improvement of Corynebacterium glutamicum to required compound (for example amino acid) output: make modified microorganism in conditions suitable (for example above-mentioned condition) growth down, the output of analyzing the required product (being amino acid) in described substratum and/or the cellular component then increases situation.Described analytical technology is that persons skilled in the art are known, comprise that spectrum detection method, thin-layer chromatography, various staining, enzyme process and micro-biological process and analytical chromatography method such as high performance liquid chromatography are (referring to for example Ullman, Encyclopedia of IndustrialChemistry, the A2 volume, 89-90 and 443-613 page or leaf, VCH:Weinheim (1985); Fallon, A. etc., (1987) " HPLC application in biological chemistry " is stated from: LaboratoryTechniques in Biochemistry and Molecular Biology, the 17th volume; Rehm etc. (1993) Biotechnology, the 3rd volume, III chapter: " the recovery purifying of product ", 469-714 page or leaf, VCH:Weinheim; Belter, P.A. etc. (1988) Bioseparations:downstream processing for biotechnology, John Wiley and Sons; Kennedy, J.F. and Cabral, J.M.S. (1992) Recovery processes for biological materials, John Wiley and Sons; Shaeiwitz, J.A. and Henry, J.D. (1988) biological chemistry separation and purification (Biochemical separations), be stated from: Ulmann ' s Encyclopedia of IndustrialChemistry, B3 volume, Chapter 11, the 1-27 page or leaf, VCH:Weinheim; And Dechow, F.J. (1989) Separation and purification techniques inbiotechnology, Noyes Publications).

Except detecting the fermentation end product, also can analysis and utilization produce other component of the pathways metabolism of required product, for example intermediate and by product are to determine to produce the overall efficiency of described compound.Analytical procedure comprises the gas that produces between nutrient level (for example sugar, hydro carbons, nitrogenous source, phosphoric acid salt and other ion), detection of biological amount composition and the growth of measuring in the substratum, the output of analyzing biosynthetic pathway common metabolic thing and yeast phase.The standard method of these detections is summarized in Applied Microbial Physiology, A Practical Approach, P.M.Rhodes and P.F.Stanbury write, IRL Press, 103-129,131-163 and 165-192 page or leaf (ISBN:0199635773) and the reference of wherein quoting.

Embodiment 10: from the required product of Corynebacterium glutamicum culture purifying

The known the whole bag of tricks in available this area reclaims required product from the Corynebacterium glutamicum cell of above-mentioned culture or supernatant liquor.If required product is not secreted from cell, can be by low-speed centrifugal from the culture harvested cell, application standard technology lysing cell, for example mechanical force or ultrasonic.Centrifugal removal cell debris keeps the supernatant liquor that contains described soluble proteins and partly supplies to be further purified needed compound.If product comes out from Corynebacterium glutamicum emiocytosis, then from described culture, remove cell by low-speed centrifugal, keep supernatant liquor partly for being further purified.

Make and to carry out chromatography from the supernatant liquor part of arbitrary purification process on appropriate resin, wherein desired molecule is retained on the chromatographic resin and the most of impurity in the sample are washed out, and perhaps impurity is retained on the resin and described sample is washed out.Can repeat described chromatographic step as required, use identical or different chromatographic resin.Persons skilled in the art are selecting suitable chromatographic resin and the most effective the utilization to be proficient in very much aspect the specific molecular to be purified.Purified product can be housed under the most stable state of temperature of product by filtering or ultrafiltration and concentration.

Many purification process known in the art are arranged, and above-mentioned purification process only is to illustrate the present invention.Such purification technique is described in for example Bailey, J.E. ﹠amp; Ollis, D.F., BiochemicalEngineering Fundamentals, McGraw-Hill: New York (1986).

The standard technique of using this area can be estimated the identity and the purity of separating compound.Described standard technique comprises high performance liquid chromatography (HPLC), spectrography, staining, thin-layer chromatography, NIRS, enzyme assay or microbiological assay.The summary of described analytical procedure is seen: Patek etc. (1994) Appl.Environ.Microbiol.60:133-140; Malakhova etc. (1996) Biotekhnologiya 11:27-32; And (1998) BioprocessEngineer such as Schmidt, 19:67-70; Ulmann ' s Encyclopedia of Industrial Chemistry, (1996) A27 volume, VCH:Weinheim, 89-90,521-540,540-547,559-566,575-581 and 581-587 page or leaf; Michal, G. (1999) Biochemical Pathways:An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons; Fallon, the application of A. etc. (1987) HPLC in biological chemistry is stated from: LaboratoryTechniques in Biochemistry and Molecular Biology, the 17th volume.

Embodiment 11: analyze gene order of the present invention

Comparative sequences also determines that the homology percentage of two kinds of sequences is technology known in the art, can adopt mathematical algorithm to finish, for example the algorithm of Karlin and Altschul ((1990) Proc.Natl.Acad Sci.USA 87:2264-68) and modified algorithm (Karlin and Altschul (1993) Proc.Natl.Acad.Sci.USA 90:5873-77 thereof.This algorithm has mixed NBLAST and the XBLAST program (2.0 editions) of (1990) J.Mol.Biol.215:403-10 such as Altschul.Can use the NBLAST program, the retrieval of BLAST Nucleotide is carried out in score value=100, byte length=12, so that obtain and HA nucleic acid molecule homologous nucleotide sequence of the present invention.Can use the XBLAST program, the retrieval of BLAST protein is carried out in score value=50, byte length=3, so that obtain and HA protein molecular homologous aminoacid sequence of the present invention.For the double-void that obtains the comparison purpose than sequence, can be according to Altschul etc., (1997) Nucleic Acids Res.25 (17): 3389-3402 is described, uses (Gapped) BLAST that introduces the room.When using BLAST and introducing the blast program in room, one skilled in the art will know that how to optimize program (for example XBLAST and the NBLAST) parameter that is used to analyze particular sequence.

Another mathematical algorithm example that is used for the sequence comparison is Meyers and Miller algorithm ((1988) Comput.Appl.Biosci.4:11-17).This algorithm has mixed ALIGN program (2.0 editions), and the ALIGN program is the integral part of GCG sequence alignment software package.When using ALIGN program comparing amino acid sequence, can use PAM120 weighting residue table, room length point penalty 12 and gap penalty 4.Other sequential analysis algorithm is known in the art, comprises ADVANCE and ADAM that Torelli and Robotti (1994) Comput.Appl.Biosci.10:3-5 introduces; And the FASTA of Pearson and Lipman (1988) P.N.A.S.85:2444-8 introduction.

Also can use GAP program in the GCG software package (can Http:// www.gcg.comObtain), select for use Blosum 62 matrixes or PAM250 matrix and room to be weighted to 12,10,8,6 or 4 and length is weighted to 2,3 or 4, obtain the homology percentage of two seed amino acid sequences.Use the GAP program in the GCG software package, use canonical parameter, for example the room is weighted to 50 and length is weighted to 3, can obtain the homology percentage of two kinds of nucleotide sequences.

Adopt technology known in the art (to write (1998) Bioinformatics:A Practical Guide to the Analysis of Genes and Proteins referring to for example Bexevanis and Ouellette, John Wiley and Sons: New York), can carry out the comparative analysis of the sequence among gene order of the present invention and the Genbank.With the gene among 3 step method comparison gene order of the present invention and the Genbank.The first step is carried out BLASTN to each sequence of the present invention and Genbank nucleotide sequence and is analyzed (for example local compare of analysis), and keeping preceding 500, to hit sequence for further analysis.Next, hit sequence to 500 and carry out FASTA retrieval (for example Lian He part and global sequence's compare of analysis, wherein the qualification district of aligned sequences).At last, adopt the GAP program (use canonical parameter) in the GCG software package, each gene order of the present invention and each preceding 3 FASTA are hit sequence carry out sequence alignment of overall importance.In order to obtain correct result, use the known method in this area and make the sequence length that takes out from Genbank be adjusted into search sequence length.Analytical results sees Table 4.To analyze the data that obtain identical with separately each gene of the present invention and each reference sequences of Genbank being carried out GAP (overall situation) for the data that obtain, and compares but analyze with such database-wide GAP (overall situation), needs remarkable minimizing computing time.The sequence of the present invention that does not have acquisition to be higher than the sequence alignment of threshold value is designated as in table 4 does not have sequence alignment information.Those skilled in the art and then should be appreciated that the GAP sequence alignment homology percentage under table 4 gauge outfit " homology (%) (GAP) " lists with European digital format, wherein ", " represents radix point.For example the numerical value " 40,345 " in this hurdle is meant " 40.345% ".

Embodiment 12: make up and the operation dna microarray

In addition, sequence of the present invention can be used for making up and use dna microarray (design of DNA array, methodology and use are well-known in the art, and its introduction: Schena is for example arranged in following document, M etc. (1995) Science 270:467-470; Wodicka, L. etc. (1997) Nature Biotechnology 15:1359-1367; DeSaizieu, A. etc. (1998) NatureBiotechnology 16:45-48; And DeRisi, J.L. etc. (1997) Science 278:680-686).

Dna microarray is solid or flexible holder, for example the material of nitrocellulose, nylon, glass, silicone or other material formation.Nucleic acid molecule combines with support surface is orderly.Suitably behind the mark, other nucleic acid or nucleic acid mixture can with the immobilized nucleic acids molecular hybridization, marker can be used to monitor and measure each strength of signal of the hybrid molecule in the localized area.This method is the relative quantity or the absolute magnitude of whole or selected nucleic acid in the quantitative nucleic acid samples of using or the mixture simultaneously.Therefore, but dna microarray parallel analysis multiple (nearly 6800 kinds or more) expression of nucleic acids (referring to for example Schena, M. (1996) BioEssays 18 (5): 427-431).

Sequence of the present invention can be used to the design oligonucleotides primer, can increase by the nucleic acid amplification reaction such as the polymerase chain reaction regulation zone of one or more Corynebacterium glutamicum genes of this Oligonucleolide primers.Select and design 5 ' or 3 ' Oligonucleolide primers or suitable joint, can make the PCR product and above-mentioned upholder dielectric surface covalently bound (also referring to for example Schena, M. etc. (1995) Science 270:467-470 introduction) that are produced.

According to Wodicka, L. etc. (1997) Nature Biotechnology 15:1359-1367 introduces, also can be by the synthetic nucleic acid microarray that makes up of original position oligonucleotide.Use the regional exposure that photolithography accurately limits matrix.Activation light unstable blocking group and add Nucleotide thus, any change then can not take place in the lucifuge district.Protection subsequently makes with the photoactivation circulation and is limiting the synthetic different oligonucleotide in position.By the solid phase synthesis oligonucleotide, can on microarray, synthesize the gene of the present invention of institute localized area.

The nucleic acid molecule of the present invention that exists in sample or the mixture of ribonucleotides can with described microarray hybridization.But according to these nucleic acid molecule of standard method mark.When in brief, for example reverse transcription or DNA are synthetic by mixing isotropic substance or fluorescent mark Nucleotide marker nucleic acid molecule (for example mRNA molecule or dna molecular).Existing introduction about labeling nucleic acid and microarray hybridization (for example be stated from: Schena, M etc. (1995) are the same; Wodicka, L etc. (1997), the same; And DeSaizieu A. etc. (1998), the same).The detection of hybrid molecule and the marker that quantitatively must suitable specifically mix.For example according to Schena, M etc. (1995) (the same) but introduce the detection of radioactive labels thing, and for example can detect fluorescent marker according to the method for ((1996) Genome Research 6:639-645) such as Shalon.

Sequence of the present invention is used for the different strains that above-mentioned dna microarray technology can relatively be analyzed Corynebacterium glutamicum or other Corynebacterium.The nucleic acid array methodology for example helps according to the distribute variation between research bacterial strain and identify specific and/or required strain characteristic such as the important gene of pathogenic, throughput and stress tolerance of each transcript.In addition, utilize the nucleic acid array technology can compare that expression of gene of the present invention distributes during the fermentation reaction.

Embodiment 13: analysis of cells albumen group motion mechanics (proteomics (Proteomics))

Gene of the present invention, composition and method can be used for studying mutual effect of albumen faciation and kinetics, are called " proteomics ".The target protein group includes but not limited to Corynebacterium glutamicum total protein group (for example and other biological albumen group relatively), under specific environment or metabolism condition (for example high temperature between yeast phase or low temperature, perhaps high pH or low pH) have active albumen, have active albumen in the specific period of g and D.

Various technology that available this area is known such as gel electrophoresis analysis protein group.For example can obtain cell protein, use various electrophoretic techniques cell protein is separated from each other by cracking or extraction.SDS-PAGE (SDS-PAGE) is mainly according to proteinic molecular weight protein isolate.Isoelectrofocusing polyacrylamide gel electrophoresis (IEF-PAGE) is by its iso-electric point (it not only reflects aminoacid sequence, and modifies after reflecting described protein translation) protein isolate.Another preferred analysis of protein method is continuous combined I EF-PAGE and SDS-PAGE, is called the 2-D-gel electrophoresis and (for example sees following document introduction: Hermann etc. (1998) Electrophoresis 19:3217-3221; Fountoulakis etc. (1998) Electrophoresis 19:1193-1202; Langen etc. (1997) Electrophoresis 18:1184-1192; Antelmann etc. (1997) Electrophoresis 18:1451-1463).Also can use other protein separation technology to carry out protein separation, for example capillary gel electrophoresis; Described technology is the known technology in this area.

The available standards technology is as the albumen that separates of method as described in dyeing or the flagrate.Suitable staining is known in the art, comprises Xylene Brilliant Cyanine G, silver dyeing or fluorescence dye such as Sypro Ruby (Molecular Probes).(for example in the Corynebacterium glutamicum substratum, contain radio-labeling amino acid or other amyloid protein precursor ³⁵The S-methionine(Met), ³⁵The S-halfcystine, ¹⁴The C-labeled amino acid, ¹⁵N-amino acid, Or Or ¹³The C-labeled amino acid) can be before it separates the albumen of these cells of mark.Can use fluorescent marker equally.Can extract according to aforementioned techniques, separately and separate described labelled protein.

Can further analyze the albumen that described technology manifests by measuring used dyestuff or marker amount.But adopt for example given protein content of optical means quantitative assay, and can compare with other the proteic amount on identical gel or other gel.The albumen that for example adopts optics comparison, spectrography, scanning of image and gel analysis or can carry out on the gel by application photographic film and screening compares.It is known that such technology is produced this area.

In order to determine any given proteic identity, can adopt direct order-checking or other standard technique.Can use for example N-and/or C-end amino acid order-checking (for example Edman edman degradation Edman), also can use mass spectroscopy (especially MALDI or ESI technology (referring to (1997) Electrophoresis 18:1184-1192 such as for example Langen)).Protein sequence provided herein can be used for by described technical evaluation Corynebacterium glutamicum albumen.

The information that described method obtains can be used for that albumen between the different samples of more various biotic conditions (for example different biology, fermentation time point, culture medium condition or different biotope etc.) exists, the pattern of active or modification.These experiments can be used for various uses separately or with data that other technical tie-up obtains, the various biological behavior of for example more given (for example metabolism) situation, improve the bacterial strain throughput of producing fine chemicals or improve the productive rate of producing fine chemicals.

Be equal to embodiment

Those skilled in the art will know that or only adopt many embodiments that are equal to of the specific embodiments of the present invention that normal experiment just can determine that this paper introduces.Following claims comprise such embodiment that is equal to.

Sequence table

＜110〉BASF AG (BASF Aktiengesellschaft)

＜120〉coding participates in the proteinic Corynebacterium glutamicum gene of homeostasis and adaptation

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<210>1

<211>314

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

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<222>(1)..(291)

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<400>1

cca?ccg?atc?tac?ttc?tcc?cac?gac?cgc?gaa?gtt?ttc?gag?cgc?gac?ggc 48

Pro?Pro?Ile?Tyr?Phe?Ser?His?Asp?Arg?Glu?Val?Phe?Glu?Arg?Asp?Gly

1 5 10 15

atg?tgg?ctg?acc?gca?ggc?gag?tgg?ggt?gga?cca?aag?aag?ggc?gag?gag 96

Met?Trp?Leu?Thr?Ala?Gly?Glu?Trp?Gly?Gly?Pro?Lys?Lys?Gly?Glu?Glu

20 25 30

atc?gtc?acc?aag?act?gtc?cgc?tac?cgc?acc?gtc?ggc?gat?atg?tcc?tgc 144

Ile?Val?Thr?Lys?Thr?Val?Arg?Tyr?Arg?Thr?Val?Gly?Asp?Met?Ser?Cys

35 40 45

acc?ggt?gct?gtg?ctc?tcc?gaa?gcc?cgc?acc?att?gac?gat?gtg?atc?gaa 192

Thr?Gly?Ala?Val?Leu?Ser?Glu?Ala?Arg?Thr?Ile?Asp?Asp?Val?Ile?Glu

50 55 60

gag?atc?gcc?acc?tcc?acc?ctt?acc?gaa?cgt?ggc?gca?acc?cgc?gcc?gat 240

Glu?Ile?Ala?Thr?Ser?Thr?Leu?Thr?Glu?Arg?Gly?Ala?Thr?Arg?Ala?Asp

65 70 75 80

gac?cgc?ctc?agc?gaa?tcc?gca?atg?gaa?gac?cgc?aag?aag?gaa?ggc?tac 288

Asp?Arg?Leu?Ser?Glu?Ser?Ala?Met?Glu?Asp?Arg?Lys?Lys?Glu?Gly?Tyr

85 90 95

ttc?tgatgactgc?tccaaccttg?aat 314

Phe

<210>2

<211>97

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>2

Pro?Pro?Ile?Tyr?Phe?Ser?His?Asp?Arg?Glu?Val?Phe?Glu?Arg?Asp?Gly

1 5 10 15

Met?Trp?Leu?Thr?Ala?Gly?Glu?Trp?Gly?Gly?Pro?Lys?Lys?Gly?Glu?Glu

20 25 30

Ile?Val?Thr?Lys?Thr?Val?Arg?Tyr?Arg?Thr?Val?Gly?Asp?Met?Ser?Cys

35 40 45

Thr?Gly?Ala?Val?Leu?Ser?Glu?Ala?Arg?Thr?Ile?Asp?Asp?Val?Ile?Glu

50 55 60

Glu?Ile?Ala?Thr?Ser?Thr?Leu?Thr?Glu?Arg?Gly?Ala?Thr?Arg?Ala?Asp

65 70 75 80

Asp?Arg?Leu?Ser?Glu?Ser?Ala?Met?Glu?Asp?Arg?Lys?Lys?Glu?Gly?Tyr

85 90 95

Phe

<210>3

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＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

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acc?ggc?gtc?tcc?acc?tcc?cag?gtt?gta?gtt?ttg?ctt?gtc?gac?gcc?cgc 48

Thr?Gly?Val?Ser?Thr?Ser?Gln?Val?Val?Val?Leu?Leu?Val?Asp?Ala?Arg

1 5 10 15

cac?ggc?gtc?gtc?gag?cag?acc?cgc?cgc?cac?ctg?tcc?gta?tcg?gct?ctg 96

His?Gly?Val?Val?Glu?Gln?Thr?Arg?Arg?His?Leu?Ser?Val?Ser?Ala?Leu

20 25 30

ctg?ggc?gta?cgc?acg?gtg?atc?ctc?gca?gtc?aac?aaa?att?gac?ctt?gtt 144

Leu?Gly?Val?Arg?Thr?Val?Ile?Leu?Ala?Val?Asn?Lys?Ile?Asp?Leu?Val

35 40 45

gat?tac?agc?gaa?gaa?gtc?ttc?cgc?aac?att?gaa?aag?gaa?ttc?gtt?ggc 192

Asp?Tyr?Ser?Glu?Glu?Val?Phe?Arg?Asn?Ile?Glu?Lys?Glu?Phe?Val?Gly

50 55 60

ctg?gca?tct?gca?ctt?gat?gtc?aca?gac?acc?cac?gtt?gtt?cca?atc?tct 240

Leu?Ala?Ser?Ala?Leu?Asp?Val?Thr?Asp?Thr?His?Val?Val?Pro?Ile?Ser

65 70 75 80

gcg?ctc?aag?ggc?gac?aac?gtt?gca?gaa?cct?tcc?acc?cac?atg?gat?tgg 288

Ala?Leu?Lys?Gly?Asp?Asn?Val?Ala?Glu?Pro?Ser?Thr?His?Met?Asp?Trp

85 90 95

tac?acc?gga?cca?acc?gtg?ctg?gaa?atc?ctg?gaa?aac?gta?gaa?gtt?tcc 336

Tyr?Thr?Gly?Pro?Thr?Val?Leu?Glu?Ile?Leu?Glu?Asn?Val?Glu?Val?Ser

100 105 110

cac?ggc?cgt?gca?cac?gac?ctg?ggc?ttc?cgc?ttc?cca?atc?cag?tac?gtc 384

His?Gly?Arg?Ala?His?Asp?Leu?Gly?Phe?Arg?Phe?Pro?Ile?Gln?Tyr?Val

115 120 125

atc?cgc?gag?cac?gcc?acc?gac?tac?cgt?ggc?tac?gcc?ggc?acc?atc?aac 432

Ile?Arg?Glu?His?Ala?Thr?Asp?Tyr?Arg?Gly?Tyr?Ala?Gly?Thr?Ile?Asn

130 135 140

gct?ggt?tcc?gtc?tcc?gtg?ggc?gat?acc?gtg?tac?cta?cct?gaa?ggc?cgc 480

Ala?Gly?Ser?Val?Ser?Val?Gly?Asp?Thr?Val?Tyr?Leu?Pro?Glu?Gly?Arg

145 150 155 160

acc?acc?cag?gtc?acc?cac?atc?gat?tcc?gct?gac?gga?tcc?ctc?cag?acc 528

Thr?Thr?Gln?Val?Thr?His?Ile?Asp?Ser?Ala?Asp?Gly?Ser?Leu?Gln?Thr

165 170 175

gca?tca?gtt?gga?gaa?gcc?gtt?gtc?ctg?cgc?cta?gcc?cag?gaa?atc?gac 576

Ala?Ser?Val?Gly?Glu?Ala?Val?Val?Leu?Arg?Leu?Ala?Gln?Glu?Ile?Asp

180 185 190

ctc?atc?cgc?ggc?gaa?ctc?atc?gct?ggc?gaa?gac?cgc?cca?gaa?tcc?gtt 624

Leu?Ile?Arg?Gly?Glu?Leu?Ile?Ala?Gly?Glu?Asp?Arg?Pro?Glu?Ser?Val

195 200 205

cgc?tcc?ttc?aac?gcc?act?gtt?gtt?ggc?ttg?gcc?gat?cgc?acc?atc?aaa 672

Arg?Ser?Phe?Asn?Ala?Thr?Val?Val?Gly?Leu?Ala?Asp?Arg?Thr?Ile?Lys

210 215 220

cca?ggt?gca?gca?gtc?aag?gtt?cgc?tac?ggc?acc?gag?ctg?gtc?cgc?gga 720

Pro?Gly?Ala?Ala?Val?Lys?Val?Arg?Tyr?Gly?Thr?Glu?Leu?Val?Arg?Gly

225 230 235 240

cgc?gtc?gca?gcc?atc?gaa?cga?gtc?ctc?gac?atc?gac?ggc?gtc?aac?gac 768

Arg?Val?Ala?Ala?Ile?Glu?Arg?Val?Leu?Asp?Ile?Asp?Gly?Val?Asn?Asp

245 250 255

aac?gaa?gca?cca?gaa?acc?tac?ggc?ctc?aac?gac?atc?gca?cac?gtg?cgc 816

Asn?Glu?Ala?Pro?Glu?Thr?Tyr?Gly?Leu?Asn?Asp?Ile?Ala?His?Val?Arg

260 265 270

atc?gac?gtt?gca?ggc?gaa?ctc?gaa?gtt?gaa?gat?tac?gct?gcc?cgc?ggc 864

Ile?Asp?Val?Ala?Gly?Glu?Leu?Glu?Val?Glu?Asp?Tyr?Ala?Ala?Arg?Gly

275 280 285

gcc?atc?gga?tcc?ttc?ctc?ctc?atc?gac?caa?tcc?tcc?ggc?gat?acc?ctc 912

Ala?Ile?Gly?Ser?Phe?Leu?Leu?Ile?Asp?Gln?Ser?Ser?Gly?Asp?Thr?Leu

290 295 300

gca?gct?ggc?ttg?gtt?ggc?cac?cgc?cta?cgc?aat?aac?tgg?tcg?atc 957

Ala?Ala?Gly?Leu?Val?Gly?His?Arg?Leu?Arg?Asn?Asn?Trp?Ser?Ile

305 310 315

tagaccagtg?tcttaggcaa?gac 980

<210>4

<211>319

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>4

Thr?Gly?Val?Ser?Thr?Ser?Gln?Val?Val?Val?Leu?Leu?Val?Asp?Ala?Arg

1 5 10 15

His?Gly?Val?Val?Glu?Gln?Thr?Arg?Arg?His?Leu?Ser?Val?Ser?Ala?Leu

20 25 30

Leu?Gly?Val?Arg?Thr?Val?Ile?Leu?Ala?Val?Asn?Lys?Ile?Asp?Leu?Val

35 40 45

Asp?Tyr?Ser?Glu?Glu?Val?Phe?Arg?Asn?Ile?Glu?Lys?Glu?Phe?Val?Gly

50 55 60

Leu?Ala?Ser?Ala?Leu?Asp?Val?Thr?Asp?Thr?His?Val?Val?Pro?Ile?Ser

65 70 75 80

Ala?Leu?Lys?Gly?Asp?Asn?Val?Ala?Glu?Pro?Ser?Thr?His?Met?Asp?Trp

85 90 95

Tyr?Thr?Gly?Pro?Thr?Val?Leu?Glu?Ile?Leu?Glu?Asn?Val?Glu?Val?Ser

100 105 110

His?Gly?Arg?Ala?His?Asp?Leu?Gly?Phe?Arg?Phe?Pro?Ile?Gln?Tyr?Val

115 120 125

Ile?Arg?Glu?His?Ala?Thr?Asp?Tyr?Arg?Gly?Tyr?Ala?Gly?Thr?Ile?Asn

130 135 140

Ala?Gly?Ser?Val?Ser?Val?Gly?Asp?Thr?Val?Tyr?Leu?Pro?Glu?Gly?Arg

145 150 155 160

Thr?Thr?Gln?Val?Thr?His?Ile?Asp?Ser?Ala?Asp?Gly?Ser?Leu?Gln?Thr

165 170 175

Ala?Ser?Val?Gly?Glu?Ala?Val?Val?Leu?Arg?Leu?Ala?Gln?Glu?Ile?Asp

180 185 190

Leu?Ile?Arg?Gly?Glu?Leu?Ile?Ala?Gly?Glu?Asp?Arg?Pro?Glu?Ser?Val

195 200 205

Arg?Ser?Phe?Asn?Ala?Thr?Val?Val?Gly?Leu?Ala?Asp?Arg?Thr?Ile?Lys

210 215 220

Pro?Gly?Ala?Ala?Val?Lys?Val?Arg?Tyr?Gly?Thr?Glu?Leu?Val?Arg?Gly

225 230 235 240

Arg?Val?Ala?Ala?Ile?Glu?Arg?Val?Leu?Asp?Ile?Asp?Gly?Val?Asn?Asp

245 250 255

Asn?Glu?Ala?Pro?Glu?Thr?Tyr?Gly?Leu?Asn?Asp?Ile?Ala?His?Val?Arg

260 265 270

Ile?Asp?Val?Ala?Gly?Glu?Leu?Glu?Val?Glu?Asp?Tyr?Ala?Ala?Arg?Gly

275 280 285

Ala?Ile?Gly?Ser?Phe?Leu?Leu?Ile?Asp?Gln?Ser?Ser?Gly?Asp?Thr?Leu

290 295 300

Ala?Ala?Gly?Leu?Val?Gly?His?Arg?Leu?Arg?Asn?Asn?Trp?Ser?Ile

305 310 315

<210>5

<211>977

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(954)

<223>FRXA00249

<400>5

ggt?gtt?ttc?acc?ttc?caa?ggt?gta?gtt?ttg?ctt?gtc?gac?gcc?cgc?cac 48

Gly?Val?Phe?Thr?Phe?Gln?Gly?Val?Val?Leu?Leu?Val?Asp?Ala?Arg?His

1 5 10 15

ggc?gtc?gtc?gag?cag?acc?cgc?cgc?cac?ctg?tcc?gta?tcg?gct?ctg?ctg 96

Gly?Val?Val?Glu?Gln?Thr?Arg?Arg?His?Leu?Ser?Val?Ser?Ala?Leu?Leu

20 25 30

ggc?gta?cgc?acg?gtg?atc?ctc?gca?gtc?aac?aaa?att?gac?ctt?gtt?gat 144

Gly?Val?Arg?Thr?Val?Ile?Leu?Ala?Val?Asn?Lys?Ile?Asp?Leu?Val?Asp

35 40 45

tac?agc?gaa?gaa?gtc?ttc?cgc?aac?att?gaa?aag?gaa?ttc?gtt?ggc?ctg 192

Tyr?Ser?Glu?Glu?Val?Phe?Arg?Asn?Ile?Glu?Lys?Glu?Phe?Val?Gly?Leu

50 55 60

gca?tct?gca?ctt?gat?gtc?aca?gac?acc?cac?gtt?gtt?cca?atc?tct?gcg 240

Ala?Ser?Ala?Leu?Asp?Val?Thr?Asp?Thr?His?Val?Val?Pro?Ile?Ser?Ala

65 70 75 80

ctc?aag?ggc?gac?aac?gtt?gca?gaa?cct?tcc?acc?cac?atg?gat?tgg?tac 288

Leu?Lys?Gly?Asp?Asn?Val?Ala?Glu?Pro?Ser?Thr?His?Met?Asp?Trp?Tyr

85 90 95

acc?gga?cca?acc?gtg?ctg?gaa?atc?ctg?gaa?aac?gta?gaa?gtt?tcc?cac 336

Thr?Gly?Pro?Thr?Val?Leu?Glu?Ile?Leu?Glu?Asn?Val?Glu?Val?Ser?His

100 105 110

ggc?cgt?gca?cac?gac?ctg?ggc?ttc?cgc?ttc?cca?atc?cag?tac?gtc?atc 384

Gly?Arg?Ala?His?Asp?Leu?Gly?Phe?Arg?Phe?Pro?Ile?Gln?Tyr?Val?Ile

115 120 125

cgc?gag?cac?gcc?acc?gac?tac?cgt?ggc?tac?gcc?ggc?acc?atc?aac?gct 432

Arg?Glu?His?Ala?Thr?Asp?Tyr?Arg?Gly?Tyr?Ala?Gly?Thr?Ile?Asn?Ala

130 135 140

ggt?tcc?gtc?tcc?gtg?ggc?gat?acc?gtg?tac?cta?cct?gaa?ggc?cgc?acc 480

Gly?Ser?Val?Ser?Val?Gly?Asp?Thr?Val?Tyr?Leu?Pro?Glu?Gly?Arg?Thr

145 150 155 160

acc?cag?gtc?acc?cac?atc?gat?tcc?gct?gac?gga?tcc?ctc?cag?acc?gca 528

Thr?Gln?Val?Thr?His?Ile?Asp?Ser?Ala?Asp?Gly?Ser?Leu?Gln?Thr?Ala

165 170 175

rca?gtt?gga?gaa?gcc?gtt?gtc?ctg?cgc?cta?gcc?cag?gaa?atc?gac?ctc 576

Ser?Val?Gly?Glu?Ala?Val?Val?Leu?Arg?Leu?Ala?Gln?Glu?Ile?Asp?Leu

180 185 190

atc?cgc?ggc?gaa?ctc?atc?gct?ggc?gaa?gac?cgc?cca?gaa?tcc?gtt?cgc 624

Ile?Arg?Gly?Glu?Leu?Ile?Ala?Gly?Glu?Asp?Arg?Pro?Glu?Ser?Val?Arg

195 200 205

tcc?ttc?aac?gcc?act?gtt?gtt?ggc?ttg?gcc?gat?cgc?acc?atc?aaa?cca 672

Ser?Phe?Asn?Ala?Thr?Val?Val?Gly?Leu?Ala?Asp?Arg?Thr?Ile?Lys?Pro

210 215 220

ggt?gca?gca?gtc?aag?gtt?cgc?tac?ggc?acc?gag?ctg?gtc?cgc?gga?cgc 720

Gly?Ala?Ala?Val?Lys?Val?Arg?Tyr?Gly?Thr?Glu?Leu?Val?Arg?Gly?Arg

225 230 235 240

gtc?gca?gcc?atc?gaa?cga?gtc?ctc?gac?atc?gac?ggc?gtc?aac?gac?aac 768

Val?Ala?Ala?Ile?Glu?Arg?Val?Leu?Asp?Ile?Asp?Gly?Val?Asn?Asp?Asn

245 250 255

gaa?gca?cca?gaa?acc?tac?ggc?ctc?aac?gac?atc?gca?cac?gtg?cgc?atc 816

Glu?Ala?Pro?Glu?Thr?Tyr?Gly?Leu?Asn?Asp?Ile?Ala?His?Val?Arg?Ile

260 265 270

gac?gtt?gca?ggc?gaa?ctc?gaa?gtt?gaa?gat?tac?gct?gcc?cgc?ggc?gcc 864

Asp?Val?Ala?Gly?Glu?Leu?Glu?Val?Glu?Asp?Tyr?Ala?Ala?Arg?Gly?Ala

275 280 285

atc?gga?tcc?ttc?ctc?ctc?atc?gac?caa?tcc?tcc?ggc?gat?acc?ctc?gca 912

Ile?Gly?Ser?Phe?Leu?Leu?Ile?Asp?Gln?Ser?Ser?Gly?Asp?Thr?Leu?Ala

290 295 300

gct?ggc?ttg?gtt?ggc?cac?cgc?cta?cgc?aat?aac?tgg?tcg?atc 954

Ala?Gly?Leu?Val?Gly?His?Arg?Leu?Arg?Asn?Asn?Trp?Ser?Ile

305 310 315

tagaccagtg?tcttaggcaa?gac 977

<210>6

<211>318

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>6

Gly?Val?Phe?Thr?Phe?Gln?Gly?Val?Val?Leu?Leu?Val?Asp?Ala?Arg?His

1 5 10 15

Gly?Val?Val?Glu?Gln?Thr?Arg?Arg?His?Leu?Ser?Val?Ser?Ala?Leu?Leu

20 25 30

Gly?Val?Arg?Thr?Val?Ile?Leu?Ala?Val?Asn?Lys?Ile?Asp?Leu?Val?Asp

35 40 45

Tyr?Ser?Glu?Glu?Val?Phe?Arg?Asn?Ile?Glu?Lys?Glu?Phe?Val?Gly?Leu

50 55 60

Ala?Ser?Ala?Leu?Asp?Val?Thr?Asp?Thr?His?Val?Val?Pro?Ile?Ser?Ala

65 70 75 80

Leu?Lys?Gly?Asp?Asn?Val?Ala?Glu?Pro?Ser?Thr?His?Met?Asp?Trp?Tyr

85 90 95

Thr?Gly?Pro?Thr?Val?Leu?Glu?Ile?Leu?Glu?Asn?Val?Glu?Val?Ser?His

100 105 110

Gly?Arg?Ala?His?Asp?Leu?Gly?Phe?Arg?Phe?Pro?Ile?Gln?Tyr?Val?Ile

115 120 125

Arg?Glu?His?Ala?Thr?Asp?Tyr?Arg?Gly?Tyr?Ala?Gly?Thr?Ile?Asn?Ala

130 135 140

Gly?Ser?Val?Ser?Val?Gly?Asp?Thr?Val?Tyr?Leu?Pro?Glu?Gly?Arg?Thr

145 150 155 160

Thr?Gln?Val?Thr?His?Ile?Asp?Ser?Ala?Asp?Gly?Ser?Leu?Gln?Thr?Ala

165 170 175

Ser?Val?Gly?Glu?Ala?Val?Val?Leu?Arg?Leu?Ala?Gln?Glu?Ile?Asp?Leu

180 185 190

Ile?Arg?Gly?Glu?Leu?Ile?Ala?Gly?Glu?Asp?Arg?Pro?Glu?Ser?Val?Arg

195 200 205

Ser?Phe?Asn?Ala?Thr?Val?Val?Gly?Leu?Ala?Asp?Arg?Thr?Ile?Lys?Pro

210 215 220

Gly?Ala?Ala?Val?Lys?Val?Arg?Tyr?Gly?Thr?Glu?Leu?Val?Arg?Gly?Arg

225 230 235 240

Val?Ala?Ala?Ile?Glu?Arg?Val?Leu?Asp?Ile?Asp?Gly?Val?Asn?Asp?Asn

245 250 255

Glu?Ala?Pro?Glu?Thr?Tyr?Gly?Leu?Asn?Asp?Ile?Ala?His?Val?Arg?Ile

260 265 270

Asp?Val?Ala?Gly?Glu?Leu?Glu?Val?Glu?Asp?Tyr?Ala?Ala?Arg?Gly?Ala

275 280 285

Ile?Gly?Ser?Phe?Leu?Leu?Ile?Asp?Gln?Ser?Ser?Gly?Asp?Thr?Leu?Ala

290 295 300

Ala?Gly?Leu?Val?Gly?His?Arg?Leu?Arg?Asn?Asn?Trp?Ser?Ile

305 310 315

<210>7

<211>954

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(931)

<223>RXA01073

<400>7

taaccgactc?cagcactaaa?ctccaaaccc?ttggcccgca?ccgccaaagt?ttagcgcgcc?60

ccaagacacc?accgcgccat?gtttgcctag?gattaggtac?atg?aca?aac?act?caa 115

Met?Thr?Asn?Thr?Gln

1 5

acc?gag?atc?att?aat?gaa?cta?aag?gtg?agc?cca?gca?atc?gac?gtg?gcc 163

Thr?Glu?Ile?Ile?Asn?Glu?Leu?Lys?Val?Ser?Pro?Ala?Ile?Asp?Val?Ala

10 15 20

aag?gaa?gtt?gaa?ttc?cgt?gtg?cag?ttc?ctc?gtc?gat?tac?ctg?cgg?gct 211

Lys?Glu?Val?Glu?Phe?Arg?Val?Gln?Phe?Leu?Val?Asp?Tyr?Leu?Arg?Ala

25 30 35

tcc?cat?aca?aaa?ggc?ttt?gtt?ctt?ggt?att?tca?ggt?ggc?cag?gat?tcc 259

Ser?His?Thr?Lys?Gly?Phe?Val?Leu?Gly?Ile?Ser?Gly?Gly?Gln?Asp?Ser

40 45 50

act?ctt?gcg?gga?cga?ctc?acg?cag?ctg?gca?gta?gag?cgc?att?cgt?gcg 307

Thr?Leu?Ala?Gly?Arg?Leu?Thr?Gln?Leu?Ala?Val?Glu?Arg?Ile?Arg?Ala

55 60 65

gaa?gaa?aac?agc?acg?gat?tat?gtc?ttc?tac?gca?gtt?cgc?ctc?ccc?tac 355

Glu?Glu?Asn?Ser?Thr?Asp?Tyr?Val?Phe?Tyr?Ala?Val?Arg?Leu?Pro?Tyr

70 75 80 85

gcg?atc?cag?gca?gat?gag?gac?gat?gcg?caa?gtt?gca?ttg?gaa?ttc?atc 403

Ala?Ile?Gln?Ala?Asp?Glu?Asp?Asp?Ala?Gln?Val?Ala?Leu?Glu?Phe?Ile

90 95 100

gca?cct?gac?aag?agc?gtg?acc?gtc?aac?gtt?aaa?gac?gca?acg?gac?gcc 451

Ala?Pro?Asp?Lys?Ser?Val?Thr?Val?Asn?Val?Lys?Asp?Ala?Thr?Asp?Ala

105 110 115

acc?gaa?gca?act?gtt?gca?gct?gct?ttg?gaa?ctt?cct?gag?ctg?acc?gac 499

Thr?Glu?Ala?Thr?Val?Ala?Ala?Ala?Leu?Glu?Leu?Pro?Glu?Leu?Thr?Asp

120 125 130

ttc?aat?cgg?ggc?aat?att?aaa?gct?cgc?caa?cgc?atg?gtt?gcc?cag?tac 547

Phe?Asn?Arg?Gly?Asn?Ile?Lys?Ala?Arg?Gln?Arg?Met?Val?Ala?Gln?Tyr

135 140 145

gca?atc?gca?ggc?cag?ttg?ggc?ttg?ctg?gtt?att?ggc?act?gat?cac?gcg 595

Ala?Ile?Ala?Gly?Gln?Leu?Gly?Leu?Leu?Val?Ile?Gly?Thr?Asp?His?Ala

150 155 160 165

gct?gaa?aac?gtc?acg?ggg?ttc?ttc?acc?aaa?ttc?ggt?gat?ggc?gca?gct 643

Ala?Glu?Asn?Val?Thr?Gly?Phe?Phe?Thr?Lys?Phe?Gly?Asp?Gly?Ala?Ala

170 175 180

gac?ctg?ctt?cct?ttg?gca?ggt?ttg?agc?aag?cgt?caa?gga?gct?gcc?att 691

Asp?Leu?Leu?Pro?Leu?Ala?Gly?Leu?Ser?Lys?Arg?Gln?Gly?Ala?Ala?Ile

185 190 195

ctg?gag?cac?ctg?ggt?gca?cct?tca?agc?acg?tgg?acc?aag?gtt?cct?acc 739

Leu?Glu?His?Leu?Gly?Ala?Pro?Ser?Ser?Thr?Trp?Thr?Lys?Val?Pro?Thr

200 205 210

gct?gat?ttg?gaa?gag?gat?cgc?cca?gcg?ttg?cca?gat?gag?gaa?gca?ctt 787

Ala?Asp?Leu?Glu?Glu?Asp?Arg?Pro?Ala?Leu?Pro?Asp?Glu?Glu?Ala?Leu

215 220 225

ggt?gtg?tcg?tat?gcg?gac?atc?gat?aat?tac?ctg?gaa?aac?aag?ccc?gat 835

Gly?Val?Ser?Tyr?Ala?Asp?Ile?Asp?Asn?Tyr?Leu?Glu?Asn?Lys?Pro?Asp

230 235 240 245

gtc?agt?gaa?aaa?gcc?cag?cag?cgc?att?gag?cac?ctg?tgg?aag?gtg?ggc 883

Val?Ser?Glu?Lys?Ala?Gln?Gln?Arg?Ile?Glu?His?Leu?Trp?Lys?Val?Gly

250 255 260

cag?cac?aag?cgc?cac?ctc?cct?gct?acc?ccg?cag?gaa?aat?tgg?tgg?cgt 931

Gln?His?Lys?Arg?His?Leu?Pro?Ala?Thr?Pro?Gln?Glu?Asn?Trp?Trp?Arg

265 270 275

taatccaaca?gtttgagtgt?cgc 954

<210>8

<211>277

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>8

Met?Thr?Asn?Thr?Gln?Thr?Glu?Ile?Ile?Asn?Glu?Leu?Lys?Val?Ser?Pro

1 5 10 15

Ala?Ile?Asp?Val?Ala?Lys?Glu?Val?Glu?Phe?Arg?Val?Gln?Phe?Leu?Val

20 25 30

Asp?Tyr?Leu?Arg?Ala?Ser?His?Thr?Lys?Gly?Phe?Val?Leu?Gly?Ile?Ser

35 40 45

Gly?Gly?Gln?Asp?Ser?Thr?Leu?Ala?Gly?Arg?Leu?Thr?Gln?Leu?Ala?Val

50 55 60

Glu?Arg?Ile?Arg?Ala?Glu?Glu?Asn?Ser?Thr?Asp?Tyr?Val?Phe?Tyr?Ala

65 70 75 80

Val?Arg?Leu?Pro?Tyr?Ala?Ile?Gln?Ala?Asp?Glu?Asp?Asp?Ala?Gln?Val

85 90 95

Ala?Leu?Glu?Phe?Ile?Ala?Pro?Asp?Lys?Ser?Val?Thr?Val?Asn?Val?Lys

100 105 110

Asp?Ala?Thr?Asp?Ala?Thr?Glu?Ala?Thr?Val?Ala?Ala?Ala?Leu?Glu?Leu

115 120 125

Pro?Glu?Leu?Thr?Asp?Phe?Asn?Arg?Gly?Asn?Ile?Lys?Ala?Arg?Gln?Arg

130 135 140

Met?Val?Ala?Gln?Tyr?Ala?Ile?Ala?Gly?Gln?Leu?Gly?Leu?Leu?Val?Ile

145 150 155 160

Gly?Thr?Asp?His?Ala?Ala?Glu?Asn?Val?Thr?Gly?Phe?Phe?Thr?Lys?Phe

165 170 175

Gly?Asp?Gly?Ala?Ala?Asp?Leu?Leu?Pro?Leu?Ala?Gly?Leu?Ser?Lys?Arg

180 185 190

Gln?Gly?Ala?Ala?Ile?Leu?Glu?His?Leu?Gly?Ala?Pro?Ser?Ser?Thr?Trp

195 200 205

Thr?Lys?Val?Pro?Thr?Ala?Asp?Leu?Glu?Glu?Asp?Arg?Pro?Ala?Leu?Pro

210 215 220

Asp?Glu?Glu?Ala?Leu?Gly?Val?Ser?Tyr?Ala?Asp?Ile?Asp?Asn?Tyr?Leu

225 230 235 240

Glu?Asn?Lys?Pro?Asp?Val?Ser?Glu?Lys?Ala?Gln?Gln?Arg?Ile?Glu?His

245 250 255

Leu?Trp?Lys?Val?Gly?Gln?His?Lys?Arg?His?Leu?Pro?Ala?Thr?Pro?Gln

260 265 270

Glu?Asn?Trp?Trp?Arg

275

<210>9

<211>609

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(586)

<223>RXN02913

<400>9

tccctgacat?ccaggttgaa?gcaacgtttg?atgacggcac?caagctcgtc?accgtgcaca?60

atcccatccg?ataacccttg?atgtttttag?gagttttgtc?atg?atc?cca?ggc?gag 115

Met?Ile?Pro?Gly?Glu

1 5

tac?atc?ctg?tcc?agc?gaa?tca?ctc?acc?gga?aat?gtt?ggg?cgc?gag?gcc 163

Tyr?Ile?Leu?Ser?Ser?Glu?Ser?Leu?Thr?Gly?Asn?Val?Gly?Arg?Glu?Ala

10 15 20

aaa?acc?atc?gaa?atc?atc?aac?acc?ggt?gat?agg?cct?gtg?cag?att?ggt 211

Lys?Thr?Ile?Glu?Ile?Ile?Asn?Thr?Gly?Asp?Arg?Pro?Val?Gln?Ile?Gly

25 30 35

tcg?cat?ttc?cac?ttc?gct?gaa?gta?aac?ccc?agc?atc?agc?ttt?gat?cgc 259

Ser?His?Phe?His?Phe?Ala?Glu?Val?Asn?Pro?Ser?Ile?Ser?Phe?Asp?Arg

40 45 50

agt?gaa?ggt?tac?ggc?ttc?cgc?ctt?gat?att?cca?tcc?ggc?acc?gcg?gtg 307

Ser?Glu?Gly?Tyr?Gly?Phe?Arg?Leu?Asp?Ile?Pro?Ser?Gly?Thr?Ala?Val

55 60 65

cgc?ctc?gag?cca?ggc?gat?gcc?cgc?acc?gtc?aac?ctt?gtt?gcc?att?ggc 355

Arg?Leu?Glu?Pro?Gly?Asp?Ala?Arg?Thr?Val?Asn?Leu?Val?Ala?Ile?Gly

70 75 80 85

ggt?gac?cgc?att?gtt?gca?ggt?ttc?cga?gat?ctc?gtc?gat?ggg?ccg?ttg 403

Gly?Asp?Arg?Ile?Val?Ala?Gly?Phe?Arg?Asp?Leu?Val?Asp?Gly?Pro?Leu

90 95 100

gag?gac?ctc?aaa?gtc?aac?gtg?tgg?gag?gga?cgc?gaa?gac?ggt?tgg?cgt 451

Glu?Asp?Leu?Lys?Val?Asn?Val?Trp?Glu?Gly?Arg?Glu?Asp?Gly?Trp?Arg

105 110 115

cgt?tcc?tca?gct?gct?ggt?gat?gct?cca?caa?gaa?ttg?cca?cag?gtc?gaa 499

Arg?Ser?Ser?Ala?Ala?Gly?Asp?Ala?Pro?Gln?Glu?Leu?Pro?Gln?Val?Glu

120 125 130

gct?gct?gaa?cgt?ggc?cgg?aaa?cta?gat?gac?gcc?act?gat?gtg?gac?aca 547

Ala?Ala?Glu?Arg?Gly?Arg?Lys?Leu?Asp?Asp?Ala?Thr?Asp?Val?Asp?Thr

135 140 145

aat?gtg?ggc?aca?gaa?gaa?ggc?ttt?gaa?gaa?ggt?cga?aat?taaatgagtt 596

Asn?Val?Gly?Thr?Glu?Glu?Gly?Phe?Glu?Glu?Gly?Arg?Asn

150 155 160

ttgagatttc?ccg 609

<210>10

<211>162

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>10

Met?Ile?Pro?Gly?Glu?Tyr?Ile?Leu?Ser?Ser?Glu?Ser?Leu?Thr?Gly?Asn

1 5 10 15

Val?Gly?Arg?Glu?Ala?Lys?Thr?Ile?Glu?Ile?Ile?Asn?Thr?Gly?Asp?Arg

20 25 30

Pro?Val?Gln?Ile?Gly?Ser?His?Phe?His?Phe?Ala?Glu?Val?Asn?Pro?Ser

35 40 45

Ile?Ser?Phe?Asp?Arg?Ser?Glu?Gly?Tyr?Gly?Phe?Arg?Leu?Asp?Ile?Pro

50 55 60

Ser?Gly?Thr?Ala?Val?Arg?Leu?Glu?Pro?Gly?Asp?Ala?Arg?Thr?Val?Asn

65 70 75 80

Leu?Val?Ala?Ile?Gly?Gly?Asp?Arg?Ile?Val?Ala?Gly?Phe?Arg?Asp?Leu

85 90 95

Val?Asp?Gly?Pro?Leu?Glu?Asp?Leu?Lys?Val?Asn?Val?Trp?Glu?Gly?Arg

100 105 110

Glu?Asp?Gly?Trp?Arg?Arg?Ser?Ser?Ala?Ala?Gly?Asp?Ala?Pro?Gln?Glu

115 120 125

Leu?Pro?Gln?Val?Glu?Ala?Ala?Glu?Arg?Gly?Arg?Lys?Leu?Asp?Asp?Ala

130 135 140

Thr?Asp?Val?Asp?Thr?Asn?Val?Gly?Thr?Glu?Glu?Gly?Phe?Glu?Glu?Gly

145 150 155 160

Arg?Asn

<210>11

<211>220

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(220)

<223>FRXA02264

<400>11

tccctgacat?ccaggttgaa?gcaacgtttg?atgacggcac?caagctcgtc?accgtgcaca?60

atcccatccg?ataacccttg?atgtttttag?gagttttgtc?atg?atc?cca?ggc?gag 115

Met?Ile?Pro?Gly?Glu

1 5

tac?atc?ctg?tcc?agc?gaa?tca?ctc?acc?gga?aat?gtt?ggg?cgc?gag?gcc 163

Tyr?Ile?Leu?Ser?Ser?Glu?Ser?Leu?Thr?Gly?Asn?Val?Gly?Arg?Glu?Ala

10 15 20

aaa?acc?atc?gaa?atc?atc?aac?acc?ggt?gat?agg?cct?gtg?cag?att?ggt 211

Lys?Thr?Ile?Glu?Ile?Ile?Asn?Thr?Gly?Asp?Arg?Pro?Val?Gln?Ile?Gly

25 30 35

tcg?cat?ttc 220

Ser?His?Phe

40

<210>12

<211>40

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>12

Met?Ile?Pro?Gly?Glu?Tyr?Ile?Leu?Ser?Ser?Glu?Ser?Leu?Thr?Gly?Asn

1 5 10 15

Val?Gly?Arg?Glu?Ala?Lys?Thr?Ile?Glu?Ile?Ile?Asn?Thr?Gly?Asp?Arg

20 25 30

Pro?Val?Gln?Ile?Gly?Ser?His?Phe

35 40

<210>13

<211>1833

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1810)

<223>RXN02274

<400>13

acaggtcgaa?gctgctgaac?gtggccggaa?actagatgac?gccactgatg?tggacacaaa?60

tgtgggcaca?gaagaaggct?ttgaagaagg?tcgaaattaa?atg?agt?ttt?gag?att 115

Met?Ser?Phe?Glu?Ile

1 5

tcc?cgc?aag?cag?tac?acc?gac?ctt?tat?ggt?cca?acc?gtt?ggc?gat?tca 163

Ser?Arg?Lys?Gln?Tyr?Thr?Asp?Leu?Tyr?Gly?Pro?Thr?Val?Gly?Asp?Ser

10 15 20

gta?cgt?ctt?gct?gat?act?gag?ctt?ttt?ctc?tgt?gtg?gaa?aaa?gat?tac 211

Val?Arg?Leu?Ala?Asp?Thr?Glu?Leu?Phe?Leu?Cys?Val?Glu?Lys?Asp?Tyr

25 30 35

gca?gca?atc?ggc?gaa?gaa?gta?gca?ttc?ggc?ggt?ggc?aag?gtc?att?cgt 259

Ala?Ala?Ile?Gly?Glu?Glu?Val?Ala?Phe?Gly?Gly?Gly?Lys?Val?Ile?Arg

40 45 50

gat?ggc?atg?ggc?caa?aat?ggc?acc?ttg?gtt?cgc?gat?gta?gat?att?ccc 307

Asp?Gly?Met?Gly?Gln?Asn?Gly?Thr?Leu?Val?Arg?Asp?Val?Asp?Ile?Pro

55 60 65

gat?acc?gtc?atc?acc?aac?gtc?atc?gtc?ctt?gac?tat?acg?ggt?gtg?tac 355

Asp?Thr?Val?Ile?Thr?Asn?Val?Ile?Val?Leu?Asp?Tyr?Thr?Gly?Val?Tyr

70 75 80 85

aaa?gct?gac?gtt?gcg?ctt?cga?gat?ggc?aaa?atc?ttc?cga?atc?gga?aag 403

Lys?Ala?Asp?Val?Ala?Leu?Arg?Asp?Gly?Lys?Ile?Phe?Arg?Ile?Gly?Lys

90 95 100

gcc?gga?aac?ccg?aat?gtc?atg?gaa?aac?gtc?gac?atc?gtc?atc?ggc?gtt 451

Ala?Gly?Asn?Pro?Asn?Val?Met?Glu?Asn?Val?Asp?Ile?Val?Ile?Gly?Val

105 110 115

gcc?acc?gac?atc?att?gct?ggt?gaa?ggc?aaa?atc?ctt?acc?gca?ggt?ggc 499

Ala?Thr?Asp?Ile?Ile?Ala?Gly?Glu?Gly?Lys?Ile?Leu?Thr?Ala?Gly?Gly

120 125 130

atc?gac?acg?cac?gtg?cac?ttc?ttg?ggc?aca?gac?cag?gtc?aac?act?gca 547

Ile?Asp?Thr?His?Val?His?Phe?Leu?Gly?Thr?Asp?Gln?Val?Asn?Thr?Ala

135 140 145

tta?gca?tca?ggt?atc?acc?acg?atg?atc?ggt?gga?ggc?acc?ggc?cca?agc 595

Leu?Ala?Ser?Gly?Ile?Thr?Thr?Met?Ile?Gly?Gly?Gly?Thr?Gly?Pro?Ser

150 155 160 165

cag?gcg?tcg?atg?gct?aca?act?gtc?acg?cca?ggt?cag?tgg?aat?acc?tac 643

Gln?Ala?Ser?Met?Ala?Thr?Thr?Val?Thr?Pro?Gly?Gln?Trp?Asn?Thr?Tyr

170 175 180

aac?atg?ctt?agt?gct?ttt?gaa?ggc?atg?ccc?atg?aac?ttt?ggc?att?ttg 691

Asn?Met?Leu?Ser?Ala?Phe?Glu?Gly?Met?Pro?Met?Asn?Phe?Gly?Ile?Leu

185 190 195

ggt?aaa?ggc?cat?ggt?tct?tcc?aaa?tct?ccg?ctg?gct?gag?cag?gtt?cgt 739

Gly?Lys?Gly?His?Gly?Ser?Ser?Lys?Ser?Pro?Leu?Ala?Glu?Gln?Val?Arg

200 205 210

gcg?ggt?gca?atc?ggt?ctg?aaa?att?cac?gag?gac?tgg?ggt?gcc?aca?cca 787

Ala?Gly?Ala?Ile?Gly?Leu?Lys?Ile?His?Glu?Asp?Trp?Gly?Ala?Thr?Pro

215 220 225

tcg?tcg?atc?aac?act?gcc?cta?gaa?gta?gcc?gat?gac?atg?gac?atc?cag 835

Ser?Ser?Ile?Asn?Thr?Ala?Leu?Glu?Val?Ala?Asp?Asp?Met?Asp?Ile?Gln

230 235 240 245

gtg?gca?ctc?cac?tcc?gat?acc?ttg?aat?gag?gcc?ggt?ttt?gtg?gaa?gac 883

Val?Ala?Leu?His?Ser?Asp?Thr?Leu?Asn?Glu?Ala?Gly?Phe?Val?Glu?Asp

250 255 260

acc?att?gaa?gcc?att?gcg?ggc?cga?gtc?atc?cat?acc?ttc?cac?acc?gaa 931

Thr?Ile?Glu?Ala?Ile?Ala?Gly?Arg?Val?Ile?His?Thr?Phe?His?Thr?Glu

265 270 275

ggt?gct?ggt?ggt?gga?cac?gct?cct?gac?cta?atc?cga?gtg?gct?gct?ctg 979

Gly?Ala?Gly?Gly?Gly?His?Ala?Pro?Asp?Leu?Ile?Arg?Val?Ala?Ala?Leu

280 285 290

cca?aac?gtg?ttg?cct?gca?tcc?acc?aac?cca?acg?ctc?cca?tac?acc?cga 1027

Pro?Asn?Val?Leu?Pro?Ala?Ser?Thr?Asn?Pro?Thr?Leu?Pro?Tyr?Thr?Arg

295 300 305

aac?act?gtt?gaa?gag?cac?ctg?gac?atg?gtg?atg?gtt?gcc?cac?cac?ctc 1075

Asn?Thr?Val?Glu?Glu?His?Leu?Asp?Met?Val?Met?Val?Ala?His?His?Leu

310 315 320 325

aac?cca?gat?att?cca?gaa?gac?gtg?gct?ttt?gcg?gat?tcc?cga?att?cgt 1123

Asn?Pro?Asp?Ile?Pro?Glu?Asp?Val?Ala?Phe?Ala?Asp?Ser?Arg?Ile?Arg

330 335 340

gcc?gaa?acg?att?gca?gcc?gaa?gat?gtg?ctt?cac?gat?atg?ggt?atc?ttc 1171

Ala?Glu?Thr?Ile?Ala?Ala?Glu?Asp?Val?Leu?His?Asp?Met?Gly?Ile?Phe

345 350 355

tct?atc?acc?tct?tcg?gat?tcc?cag?gcg?atg?ggc?cga?gta?gga?gag?acc 1219

Ser?Ile?Thr?Ser?Ser?Asp?Ser?Gln?Ala?Met?Gly?Arg?Val?Gly?Glu?Thr

360 365 370

atc?acg?cgc?acg?tgg?cag?gtc?gcc?gac?cat?atg?aaa?cgc?acc?cgt?gga 1267

Ile?Thr?Arg?Thr?Trp?Gln?Val?Ala?Asp?His?Met?Lys?Arg?Thr?Arg?Gly

375 380 385

tca?cta?acg?gga?gat?gct?cca?tac?aac?gac?aac?aac?cgc?ttg?cgt?cga 1315

Ser?Leu?Thr?Gly?Asp?Ala?Pro?Tyr?Asn?Asp?Asn?Asn?Arg?Leu?Arg?Arg

390 395 400 405

ttc?atc?gca?aaa?tac?acc?atc?aac?cct?gcg?att?gcg?cac?ggt?gtg?gat 1363

Phe?Ile?Ala?Lys?Tyr?Thr?Ile?Asn?Pro?Ala?Ile?Ala?His?Gly?Val?Asp

410 415 420

tat?gtt?gtt?cgt?tca?gtg?gag?gaa?ggc?aag?ttc?gct?gac?ctc?gtg?ctg 1411

Tyr?Val?Val?Arg?Ser?Val?Glu?Glu?Gly?Lys?Phe?Ala?Asp?Leu?Val?Leu

425 430 435

tgg?gat?cca?aag?ttc?ttt?ggt?gtg?aaa?cct?gat?ctg?gtg?atc?aag?ggt 1459

Trp?Asp?Pro?Lys?Phe?Phe?Gly?Val?Lys?Pro?Asp?Leu?Val?Ile?Lys?Gly

440 445 450

ggg?ttg?atg?gtc?aat?tcc?ctc?atg?ggt?gat?tcc?aac?ggt?tcc?att?cca 1507

Gly?Leu?Met?Val?Asn?Ser?Leu?Met?Gly?Asp?Ser?Asn?Gly?Ser?Ile?Pro

455 460 465

act?ccg?cag?ccc?cgc?acc?ctg?cgc?aat?act?tgg?ggt?gcg?ttt?ggc?cag 1555

Thr?Pro?Gln?Pro?Arg?Thr?Leu?Arg?Asn?Thr?Trp?Gly?Ala?Phe?Gly?Gln

470 475 480 485

gca?gtt?tcc?aga?agc?tcc?att?aca?ttc?cta?tcc?cag?gac?gct?atc?gat 1603

Ala?Val?Ser?Arg?Ser?Ser?Ile?Thr?Phe?Leu?Ser?Gln?Asp?Ala?Ile?Asp

490 495 500

gca?aat?gtt?cct?gat?ctg?ctg?aat?ctg?agg?aag?cag?atc?cgg?ggc?gtt 1651

Ala?Asn?Val?Pro?Asp?Leu?Leu?Asn?Leu?Arg?Lys?Gln?Ile?Arg?Gly?Val

505 510 515

cga?ggt?gta?agg?aat?ctg?acc?aaa?cga?gac?atg?aaa?ctc?aat?gca?gaa 1699

Arg?Gly?Val?Arg?Asn?Leu?Thr?Lys?Arg?Asp?Met?Lys?Leu?Asn?Ala?Glu

520 525 530

atg?cct?gat?att?cgt?gtc?gat?cca?gag?acc?tac?cag?gtg?ttt?gtc?aac 1747

Met?Pro?Asp?Ile?Arg?Val?Asp?Pro?Glu?Thr?Tyr?Gln?Val?Phe?Val?Asn

535 540 545

ggt?gag?ttg?atc?acc?agc?aag?cca?gca?gag?aca?gtg?cca?atg?gca?cgt 1795

Gly?Glu?Leu?Ile?Thr?Ser?Lys?Pro?Ala?Glu?Thr?Val?Pro?Met?Ala?Arg

550 555 560 565

cgc?tacttc?ttg?ttc?taatccgcca?acaaggaagg?aag 1833

Arg?Tyr?Phe?Leu?Phe

570

<210>14

<211>570

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>14

Met?Ser?Phe?Glu?Ile?Ser?Arg?Lys?Gln?Tyr?Thr?Asp?Leu?Tyr?Gly?Pro

1 5 10 15

Thr?Val?Gly?Asp?Ser?Val?Arg?Leu?Ala?Asp?Thr?Glu?Leu?Phe?Leu?Cys

20 25 30

Val?Glu?Lys?Asp?Tyr?Ala?Ala?Ile?Gly?Glu?Glu?Val?Ala?Phe?Gly?Gly

35 40 45

Gly?Lys?Val?Ile?Arg?Asp?Gly?Met?Gly?Gln?Asn?Gly?Thr?Leu?Val?Arg

50 55 60

Asp?Val?Asp?Ile?Pro?Asp?Thr?Val?Ile?Thr?Asn?Val?Ile?Val?Leu?Asp

65 70 75 80

Tyr?Thr?Gly?Val?Tyr?Lys?Ala?Asp?Val?Ala?Leu?Arg?Asp?Gly?Lys?Ile

85 90 95

Phe?Arg?Ile?Gly?Lys?Ala?Gly?Asn?Pro?Asn?Val?Met?Glu?Asn?Val?Asp

100 105 110

Ile?Val?Ile?Gly?Val?Ala?Thr?Asp?Ile?Ile?Ala?Gly?Glu?Gly?Lys?Ile

115 120 125

Leu?Thr?Ala?Gly?Gly?Ile?Asp?Thr?His?Val?His?Phe?Leu?Gly?Thr?Asp

130 135 140

Gln?Val?Asn?Thr?Ala?Leu?Ala?Ser?Gly?Ile?Thr?Thr?Met?Ile?Gly?Gly

145 150 155 160

Gly?Thr?Gly?Pro?Ser?Gln?Ala?Ser?Met?Ala?Thr?Thr?Val?Thr?Pro?Gly

165 170 175

Gln?Trp?Asn?Thr?Tyr?Asn?Met?Leu?Ser?Ala?Phe?Glu?Gly?Met?Pro?Met

180 185 190

Asn?Phe?Gly?Ile?Leu?Gly?Lys?Gly?His?Gly?Ser?Ser?Lys?Ser?Pro?Leu

195 200 205

Ala?Glu?Gln?Val?Arg?Ala?Gly?Ala?Ile?Gly?Leu?Lys?Ile?His?Glu?Asp

210 215 220

Trp?Gly?Ala?Thr?Pro?Ser?Ser?Ile?Asn?Thr?Ala?Leu?Glu?Val?Ala?Asp

225 230 235 240

Asp?Met?Asp?Ile?Gln?Val?Ala?Leu?His?Ser?Asp?Thr?Leu?Asn?Glu?Ala

245 250 255

Gly?Phe?Val?Glu?Asp?Thr?Ile?Glu?Ala?Ile?Ala?Gly?Arg?Val?Ile?His

260 265 270

Thr?Phe?His?Thr?Glu?Gly?Ala?Gly?Gly?Gly?His?Ala?Pro?Asp?Leu?Ile

275 280 285

Arg?Val?Ala?Ala?Leu?Pro?Asn?Val?Leu?Pro?Ala?Ser?Thr?Asn?Pro?Thr

290 295 300

Leu?Pro?Tyr?Thr?Arg?Asn?Thr?Val?Glu?Glu?His?Leu?Asp?Met?Val?Met

305 310 315 320

Val?Ala?His?His?Leu?Asn?Pro?Asp?Ile?Pro?Glu?Asp?Val?Ala?Phe?Ala

325 330 335

Asp?Ser?Arg?Ile?Arg?Ala?Glu?Thr?Ile?Ala?Ala?Glu?Asp?Val?Leu?His

340 345 350

Asp?Met?Gly?Ile?Phe?Ser?Ile?Thr?Ser?Ser?Asp?Ser?Gln?Ala?Met?Gly

355 360 365

Arg?Val?Gly?Glu?Thr?Ile?Thr?Arg?Thr?Trp?Gln?Val?Ala?Asp?His?Met

370 375 380

Lys?Arg?Thr?Arg?Gly?Ser?Leu?Thr?Gly?Asp?Ala?Pro?Tyr?Asn?Asp?Asn

385 390 395 400

Asn?Arg?Leu?Arg?Arg?Phe?Ile?Ala?Lys?Tyr?Thr?Ile?Asn?Pro?Ala?Ile

405 410 415

Ala?His?Gly?Val?Asp?Tyr?Val?Val?Arg?Ser?Val?Glu?Glu?Gly?Lys?Phe

420 425 430

Ala?Asp?Leu?Val?Leu?Trp?Asp?Pro?Lys?Phe?Phe?Gly?Val?Lys?Pro?Asp

435 440 445

Leu?Val?Ile?Lys?Gly?Gly?Leu?Met?Val?Asn?Ser?Leu?Met?Gly?Asp?Ser

450 455 460

Asn?Gly?Ser?Ile?Pro?Thr?Pro?Gln?Pro?Arg?Thr?Leu?Arg?Asn?Thr?Trp

465 470 475 480

Gly?Ala?Phe?Gly?Gln?Ala?Val?Ser?Arg?Ser?Ser?Ile?Thr?Phe?Leu?Ser

485 490 495

Gln?Asp?Ala?Ile?Asp?Ala?Asn?Val?Pro?Asp?Leu?Leu?Asn?Leu?Arg?Lys

500 505 510

Gln?Ile?Arg?Gly?Val?Arg?Gly?Val?Arg?Asn?Leu?Thr?Lys?Arg?Asp?Met

515 520 525

Lys?Leu?Asn?Ala?Glu?Met?Pro?Asp?Ile?Arg?Val?Asp?Pro?Glu?Thr?Tyr

530 535 540

Gln?Val?Phe?Val?Asn?Gly?Glu?Leu?Ile?Thr?Ser?Lys?Pro?Ala?Glu?Thr

545 550 555 560

Val?Pro?Met?Ala?Arg?Arg?Tyr?Phe?Leu?Phe

565 570

<210>15

<211>1625

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(1602)

<223>FRXA02274

<400>15

tac?gca?gca?atc?ggc?gaa?gaa?gta?gca?ttc?ggc?ggt?ggc?aag?gtc?att 48

Tyr?Ala?Ala?Ile?Gly?Glu?Glu?Val?Ala?Phe?Gly?Gly?Gly?Lys?Val?Ile

1 5 10 15

cgt?gat?ggc?atg?ggc?caa?aat?ggc?acc?ttg?gtt?cgc?gat?gta?gat?att 96

Arg?Asp?Gly?Met?Gly?Gln?Asn?Gly?Thr?Leu?Val?Arg?Asp?Val?Asp?Ile

20 25 30

ccc?gat?acc?gtc?atc?acc?aac?gtc?atc?gtc?ctt?gac?tat?acg?ggt?gtg 144

Pro?Asp?Thr?Val?Ile?Thr?Asn?Val?Ile?Val?Leu?Asp?Tyr?Thr?Gly?Val

35 40 45

tac?aaa?gct?gac?gtt?gcg?ctt?cga?gat?ggc?aaa?atc?ttc?cga?atc?gga 192

Tyr?Lys?Ala?Asp?Val?Ala?Leu?Arg?Asp?Gly?Lys?Ile?Phe?Arg?Ile?Gly

50 55 60

aag?gcc?gga?aac?ccg?aat?gtc?atg?gaa?aac?gtc?gac?atc?gtc?atc?ggc 240

Lys?Ala?Gly?Asn?Pro?Asn?Val?Met?Glu?Asn?Val?Asp?Ile?Val?Ile?Gly

65 70 75 80

gtt?gcc?acc?gac?atc?att?gct?ggt?gaa?ggc?aaa?atc?ctt?acc?gca?ggt 288

Val?Ala?Thr?Asp?Ile?Ile?Ala?Gly?Glu?Gly?Lys?Ile?Leu?Thr?Ala?Gly

85 90 95

ggc?atc?gac?acg?cac?gtg?cac?ttc?ttg?ggc?aca?gac?cag?gtc?aac?act 336

Gly?Ile?Asp?Thr?His?Val?His?Phe?Leu?Gly?Thr?Asp?Gln?Val?Asn?Thr

100 105 110

gca?tta?gca?tca?ggt?atc?acc?acg?atg?atc?ggt?gga?ggc?acc?ggc?cca 384

Ala?Leu?Ala?Ser?Gly?Ile?Thr?Thr?Met?Ile?Gly?Gly?Gly?Thr?Gly?Pro

115 120 125

agc?cag?gcg?tcg?atg?gct?aca?act?gtc?acg?cca?ggt?cag?tgg?aat?acc 432

Ser?Gln?Ala?Ser?Met?Ala?Thr?Thr?Val?Thr?Pro?Gly?Gln?Trp?Asn?Thr

130 135 140

tac?aac?atg?ctt?agt?gct?ttt?gaa?ggc?atg?ccc?atg?aac?ttt?ggc?att 480

Tyr?Asn?Met?Leu?Ser?Ala?Phe?Glu?Gly?Met?Pro?Met?Asn?Phe?Gly?Ile

145 150 155 160

ttg?ggt?aaa?ggc?cat?ggt?tct?tcc?aaa?tct?ccg?ctg?gct?gag?cag?gtt 528

Leu?Gly?Lys?Gly?His?Gly?Ser?Ser?Lys?Ser?Pro?Leu?Ala?Glu?Gln?Val

165 170 175

cgt?gcg?ggt?gca?atc?ggt?ctg?aaa?att?cac?gag?gac?tgg?ggt?gcc?aca 576

Arg?Ala?Gly?Ala?Ile?Gly?Leu?Lys?Ile?His?Glu?Asp?Trp?Gly?Ala?Thr

180 185 190

cca?tcg?tcg?atc?aac?act?gcc?cta?gaa?gta?gcc?gat?gac?atg?gac?atc 624

Pro?Ser?Ser?Ile?Asn?Thr?Ala?Leu?Glu?Val?Ala?Asp?Asp?Met?Asp?Ile

195 200 205

cag?gtg?gca?crc?cac?tcc?gat?acc?ttg?aat?gag?gcc?ggt?ttt?gtg?gaa 672

Gln?Val?Ala?Leu?His?Ser?Asp?Thr?Leu?Asn?Glu?Ala?Gly?Phe?Val?Glu

210 215 220

gac?acc?att?gaa?gcc?att?gcg?ggc?cga?gtc?atc?cat?acc?ttc?cac?acc 720

Asp?Thr?Ile?Glu?Ala?Ile?Ala?Gly?Arg?Val?Ile?His?Thr?Phe?His?Thr

225 230 235 240

gaa?ggt?gct?ggt?ggt?gga?cac?gct?cct?gac?cta?atc?cga?gtg?gct?gct 768

Glu?Gly?Ala?Gly?Gly?Gly?His?Ala?Pro?Asp?Leu?Ile?Arg?Val?Ala?Ala

245 250 255

ctg?cca?aac?gtg?ttg?cct?gca?tcc?acc?aac?cca?acg?ctc?cca?tac?acc 816

Leu?Pro?Asn?Val?Leu?Pro?Ala?Ser?Thr?Asn?Pro?Thr?Leu?Pro?Tyr?Thr

260 265 270

cga?aac?act?gtt?gaa?gag?cac?ctg?gac?atg?gtg?atg?gtt?gcc?cac?cac 864

Arg?Asn?Thr?Val?Glu?Glu?His?Leu?Asp?Met?Val?Met?Val?Ala?His?His

275 280 285

ctc?aac?cca?gat?att?cca?gaa?gac?gtg?gct?ttt?gcg?gat?tcc?cga?att 912

Leu?Asn?Pro?Asp?Ile?Pro?Glu?Asp?Val?Ala?Phe?Ala?Asp?Ser?Arg?Ile

290 295 300

cgt?gcc?gaa?acg?att?gca?gcc?gaa?gat?gtg?ctt?cac?gat?atg?ggt?atc 960

Arg?Ala?Glu?Thr?Ile?Ala?Ala?Glu?Asp?Val?Leu?His?Asp?Met?Gly?Ile

305 310 315 320

ttc?tct?atc?acc?tct?tcg?gat?tcc?cag?gcg?atg?ggc?cga?gta?gga?gag 1008

Phe?Ser?Ile?Thr?Ser?Ser?Asp?Ser?Gln?Ala?Met?Gly?Arg?Val?Gly?Glu

325 330 335

acc?atc?acg?cgc?acg?tgg?cag?gtc?gcc?gac?cat?atg?aaa?cgc?acc?cgt 1056

Thr?Ile?Thr?Arg?Thr?Trp?Gln?Val?Ala?Asp?His?Met?Lys?Arg?Thr?Arg

340 345 350

gga?tca?cta?acg?gga?gat?gct?cca?tac?aac?gac?aac?aac?cgc?ttg?cgt 1104

Gly?Ser?Leu?Thr?Gly?Asp?Ala?Pro?Tyr?Asn?Asp?Asn?Asn?Arg?Leu?Arg

355 360 365

cga?ttc?atc?gca?aaa?tac?acc?atc?aac?cct?gcg?att?gcg?cac?ggt?gtg 1152

Arg?Phe?Ile?Ala?Lys?Tyr?Thr?Ile?Asn?Pro?Ala?Ile?Ala?His?Gly?Val

370 375 380

gat?tat?gtt?gtt?cgt?tca?gtg?gag?gaa?ggc?aag?ttc?gct?gac?ctc?gtg 1200

Asp?Tyr?Val?Val?Arg?Ser?Val?Glu?Glu?Gly?Lys?Phe?Ala?Asp?Leu?Val

385 390 395 400

ctg?tgg?gat?cca?aag?ttc?ttt?ggt?gtg?aaa?cct?gat?ctg?gtg?atc?aag 1248

Leu?Trp?Asp?Pro?Lys?Phe?Phe?Gly?Val?Lys?Pro?Asp?Leu?Val?Ile?Lys

405 410 415

ggt?ggg?ttg?atg?gtc?aat?tcc?ctc?atg?ggt?gat?tcc?aac?ggt?tcc?att 1296

Gly?Gly?Leu?Met?Val?Asn?Ser?Leu?Met?Gly?Asp?Ser?Asn?Gly?Ser?Ile

420 425 430

cca?act?ccg?cag?ccc?cgc?acc?ctg?cgc?aat?act?tgg?ggt?gcg?ttt?ggc 1344

Pro?Thr?Pro?Gln?Pro?Arg?Thr?Leu?Arg?Asn?Thr?Trp?Gly?Ala?Phe?Gly

435 440 445

cag?gca?gtt?tcc?aga?agc?tcc?att?aca?ttc?cta?tcc?cag?gac?gct?atc 1392

Gln?Ala?Val?Ser?Arg?Ser?Ser?Ile?Thr?Phe?Leu?Ser?Gln?Asp?Ala?Ile

450 455 460

gat?gca?aat?gtt?cct?gat?ctg?ctg?aat?ctg?agg?aag?cag?atc?cgg?ggc 1440

Asp?Ala?Asn?Val?Pro?Asp?Leu?Leu?Asn?Leu?Arg?Lys?Gln?Ile?Arg?Gly

465 470 475 480

gtt?cga?ggt?gta?agg?aat?ctg?acc?aaa?cga?gac?atg?aaa?ctc?aat?gca 1488

Val?Arg?Gly?Val?Arg?Asn?Leu?Thr?Lys?Arg?Asp?Met?Lys?Leu?Asn?Ala

485 490 495

gaa?atg?cct?gat?att?cgt?gtc?gat?cca?gag?acc?tac?cag?gtg?ttt?gtc 1536

Glu?Met?Pro?Asp?Ile?Arg?Val?Asp?Pro?Glu?Thr?Tyr?Gln?Val?Phe?Val

500 505 510

aac?ggt?gag?ttg?atc?acc?agc?aag?cca?gca?gag?aca?gtg?cca?atg?gca 1584

Asn?Gly?Glu?Leu?Ile?Thr?Ser?Lys?Pro?Ala?Glu?Thr?Val?Pro?Met?Ala

515 520 525

cgt?cgc?tacttc?ttg?ttc?taatccgcca?acaaggaagg?aag 1625

Arg?Arg?Tyr?Phe?Leu?Phe

530

<210>16

<211>534

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>16

Tyr?Ala?Ala?Ile?Gly?Glu?Glu?Val?Ala?Phe?Gly?Gly?Gly?Lys?Val?Ile

1 5 10 15

Arg?Asp?Gly?Met?Gly?Gln?Asn?Gly?Thr?Leu?Val?Arg?Asp?Val?Asp?Ile

20 25 30

Pro?Asp?Thr?Val?Ile?Thr?Asn?Val?Ile?Val?Leu?Asp?Tyr?Thr?Gly?Val

35 40 45

Tyr?Lys?Ala?Asp?Val?Ala?Leu?Arg?Asp?Gly?Lys?Ile?Phe?Arg?Ile?Gly

50 55 60

Lys?Ala?Gly?Asn?Pro?Asn?Val?Met?Glu?Asn?Val?Asp?Ile?Val?Ile?Gly

65 70 75 80

Val?Ala?Thr?Asp?Ile?Ile?Ala?Gly?Glu?Gly?Lys?Ile?Leu?Thr?Ala?Gly

85 90 95

Gly?Ile?Asp?Thr?His?Val?His?Phe?Leu?Gly?Thr?Asp?Gln?Val?Asn?Thr

100 105 110

Ala?Leu?Ala?Ser?Gly?Ile?Thr?Thr?Met?Ile?Gly?Gly?Gly?Thr?Gly?Pro

115 120 125

Ser?Gln?Ala?Ser?Met?Ala?Thr?Thr?Val?Thr?Pro?Gly?Gln?Trp?Asn?Thr

130 135 140

Tyr?Asn?Met?Leu?Ser?Ala?Phe?Glu?Gly?Met?Pro?Met?Asn?Phe?Gly?Ile

145 150 155 160

Leu?Gly?Lys?Gly?His?Gly?Ser?Ser?Lys?Ser?Pro?Leu?Ala?Glu?Gln?Val

165 170 175

Arg?Ala?Gly?Ala?Ile?GIy?Leu?Lys?Ile?His?Glu?Asp?Trp?Gly?Ala?Thr

180 185 190

Pro?Ser?Ser?Ile?Asn?Thr?Ala?Leu?Glu?Val?Ala?Asp?Asp?Met?Asp?Ile

195 200 205

Gln?Val?Ala?Leu?His?Ser?Asp?Thr?Leu?Asn?Glu?Ala?Gly?Phe?Val?Glu

210 215 220

Asp?Thr?Ile?Glu?Ala?Ile?Ala?Gly?Arg?Val?Ile?His?Thr?Phe?His?Thr

225 230 235 240

Glu?Gly?Ala?Gly?Gly?Gly?His?Ala?Pro?Asp?Leu?Ile?Arg?Val?Ala?Ala

245 250 255

Leu?Pro?Asn?Val?Leu?Pro?Ala?Ser?Thr?Asn?Pro?Thr?Leu?Pro?Tyr?Thr

260 265 270

Arg?Asn?Thr?Val?Glu?Glu?His?Leu?Asp?Met?Val?Met?Val?Ala?His?His

275 280 285

Leu?Asn?Pro?Asp?Ile?Pro?Glu?Asp?Val?Ala?Phe?Ala?Asp?Ser?Arg?Ile

290 295 300

Arg?Ala?Glu?Thr?Ile?Ala?Ala?Glu?Asp?Val?Leu?His?Asp?Met?Gly?Ile

305 310 315 320

Phe?Ser?Ile?Thr?Ser?Ser?Asp?Ser?Gln?Ala?Met?Gly?Arg?Val?Gly?Glu

325 330 335

Thr?Ile?Thr?Arg?Thr?Trp?Gln?Val?Ala?Asp?His?Met?Lys?Arg?Thr?Arg

340 345 350

Gly?Ser?Leu?Thr?Gly?Asp?Ala?Pro?Tyr?Asn?Asp?Asn?Asn?Arg?Leu?Arg

355 360 365

Arg?Phe?Ile?Ala?Lys?Tyr?Thr?Ile?Asn?Pro?Ala?Ile?Ala?His?Gly?Val

370 375 380

Asp?Tyr?Val?Val?Arg?Ser?Val?Glu?Glu?Gly?Lys?Phe?Ala?Asp?Leu?Val

385 390 395 400

Leu?Trp?Asp?Pro?Lys?Phe?Phe?Gly?Val?Lys?Pro?Asp?Leu?Val?Ile?Lys

405 410 415

Gly?Gly?Leu?Met?Val?Asn?Ser?Leu?Met?Gly?Asp?Ser?Asn?Gly?Ser?Ile

420 425 430

Pro?Thr?Pro?Gln?Pro?Arg?Thr?Leu?Arg?Asn?Thr?Trp?Gly?Ala?Phe?Gly

435 440 445

Gln?Ala?Val?Ser?Arg?Ser?Ser?Ile?Thr?Phe?Leu?Ser?Gln?Asp?Ala?Ile

450 455 460

Asp?Ala?Asn?Val?Pro?Asp?Leu?Leu?Asn?Leu?Arg?Lys?Gln?Ile?Arg?Gly

465 470 475 480

Val?Arg?Gly?Val?Arg?Asn?Leu?Thr?Lys?Arg?Asp?Met?Lys?Leu?Asn?Ala

485 490 495

Glu?Met?Pro?Asp?Ile?Arg?Val?Asp?Pro?Glu?Thr?Tyr?Gln?Val?Phe?Val

500 505 510

Asn?Gly?Glu?Leu?Ile?Thr?Ser?Lys?Pro?Ala?Glu?Thr?Val?Pro?Met?Ala

515 520 525

Arg?Arg?Tyr?Phe?Leu?Phe

530

<210>17

<211>423

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(400)

<223>RXA02265

<400>17

tcaaaggaaa?gcagtatatt?gtcggttttt?tagaggctct?cccaaatatt?gcgttggggg?60

agctaaacta?atttctgtta?cctgacagaa?aggggcaaaa?ttg?cat?atc?act?cct 115

Leu?His?Ile?Thr?Pro

1 5

cgt?gaa?caa?gaa?aaa?ctg?atg?atc?gtg?gtg?gcg?gct?gac?ctt?gca?cgt 163

Arg?Glu?Gln?Glu?Lys?Leu?Met?Ile?Val?Val?Ala?Ala?Asp?Leu?Ala?Arg

10 15 20

cgc?cgt?aaa?gat?cgc?ggc?cta?aaa?ctt?aac?cac?cca?gag?gcc?gtc?gcc 211

Arg?Arg?Lys?Asp?Arg?Gly?Leu?Lys?Leu?Asn?His?Pro?Glu?Ala?Val?Ala

25 30 35

ctc?atc?acg?tat?gaa?ctg?att?gaa?ggc?gcc?cgt?gac?gga?cgc?aca?gtc 259

Leu?Ile?Thr?Tyr?Glu?Leu?Ile?Glu?Gly?Ala?Arg?Asp?Gly?Arg?Thr?Val

40 45 50

gca?gac?ctt?atg?agc?tgg?gga?agc?acc?att?ttg?act?agg?gat?gat?gtc 307

Ala?Asp?Leu?Met?Ser?Trp?Gly?Ser?Thr?Ile?Leu?Thr?Arg?Asp?Asp?Val

55 60 65

tta?gaa?ggc?atc?cca?gag?atg?atc?cct?gac?atc?cag?gtt?gaa?gca?acg 355

Leu?Glu?Gly?Ile?Pro?Glu?Met?Ile?Pro?Asp?Ile?Gln?Val?Glu?Ala?Thr

70 75 80 85

ttt?gat?gac?ggc?acc?aag?ctc?gtc?acc?gtg?cac?aat?ccc?atc?cga 400

Phe?Asp?Asp?Gly?Thr?Lys?Leu?Val?Thr?Val?His?ASn?Pro?Ile?Arg

90 95 100

taacccttga?tgtttttagg?agt 423

<210>18

<211>100

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>18

Leu?His?Ile?Thr?Pro?Arg?Glu?Gln?Glu?Lys?Leu?Met?Ile?Val?Val?Ala

1 5 10 15

Ala?Asp?Leu?Ala?Arg?Arg?Arg?Lys?Asp?Arg?Gly?Leu?Lys?Leu?Asn?His

20 25 30

Pro?Glu?Ala?Val?Ala?Leu?Ile?Thr?Tyr?Glu?Leu?Ile?Glu?Gly?Ala?Arg

35 40 45

Asp?Gly?Arg?Thr?Val?Ala?Asp?Leu?Met?Ser?Trp?Gly?Ser?Thr?Ile?Leu

50 55 60

Thr?Arg?Asp?Asp?Val?Leu?Glu?Gly?Ile?Pro?Glu?Met?Ile?Pro?Asp?Ile

65 70 75 80

Gln?Val?Glu?Ala?Thr?Phe?Asp?Asp?Gly?Thr?Lys?Leu?Val?Thr?Val?His

85 90 95

Asn?Pro?Ile?Arg

100

<210>19

<211>972

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(949)

<223>RXA02278

<400>19

accattctgc?ctgactaatc?tgcgcaccga?tgatggtttg?gataaggtct?tggaatggat?60

ccgccatgag?gtgatgatgc?aggacttgca?ggaagcctaa?atg?aca?caa?acc?caa 115

Met?Thr?Gln?Thr?Gln

1 5

cca?gtg?gga?acc?etg?cga?ctg?acc?ate?gat?gat?caa?gga?ccc?caa?ggt 163

Pro?Val?Gly?Thr?Leu?Arg?Leu?Thr?Ile?Asp?Asp?Gln?Gly?Pro?Gln?Gly

10 15 20

caa?agc?cgt?gcg?gtg?gag?caa?ttt?cac?cag?ggt?gcg?ctt?cga?gtc?atc 211

Gln?Ser?Arg?Ala?Val?Glu?Gln?Phe?His?Gln?Gly?Ala?Leu?Arg?Val?Ile

25 30 35

cgg?cca?cac?tac?ttg?gat?gat?tcc?gga?cag?gtt?tgc?tac?acc?atc?att 259

Arg?Pro?His?Tyr?Leu?Asp?Asp?Ser?Gly?Gln?Val?Cys?Tyr?Thr?Ile?Ile

40 45 50

gcc?att?ggt?ggc?gga?tac?ctg?ggc?ggc?gat?gtg?tat?gag?cag?caa?ttc 307

Ala?Ile?Gly?Gly?Gly?Tyr?Leu?Gly?Gly?Asp?Val?Tyr?Glu?Gln?Gln?Phe

55 60 65

acg?atc?aaa?gac?aac?gca?aaa?gct?ttg?atc?acc?acg?caa?tcg?gcc?acc 355

Thr?Ile?Lys?Asp?Asn?Ala?Lys?Ala?Leu?Ile?Thr?Thr?Gln?Ser?Ala?Thr

70 75 80 85

aag?att?tat?cgc?aca?ccg?caa?gga?cca?gcc?acg?cag?cac?acc?gaa?atc 403

Lys?Ile?Tyr?Arg?Thr?Pro?Gln?Gly?Pro?Ala?Thr?Gln?His?Thr?Glu?Ile

90 95 100

aac?gtc?ggt?gaa?aat?gct?gtg?ctg?gaa?tac?ttg?gcg?gat?caa?acc?atc 451

ASn?Val?Gly?Glu?Asn?Ala?Val?Leu?Glu?Tyr?Leu?Ala?Asp?Gln?Thr?Ile

105 110 115

gcg?tac?cgg?gag?gcc?acc?tat?cat?caa?ttc?acc?aag?gtg?gcg?ctg?cac 499

Ala?Tyr?Arg?Glu?Ala?Thr?Tyr?His?Gln?Phe?Thr?Lys?Val?Ala?Leu?His

120 125 130

ccg?agc?gca?acg?ttt?gtg?atg?agc?gaa?caa?atc?acc?cca?ggc?tgg?cac 547

Pro?Ser?Ala?Thr?Phe?Val?Met?Ser?Glu?Gln?Ile?Thr?Pro?Gly?Trp?His

135 140 145

ccc?gac?ggc?aaa?cac?ttt?gct?tac?gat?gaa?atg?cgt?cta?cac?acc?gaa 595

Pro?Asp?Gly?Lys?His?Phe?Ala?Tyr?Asp?Glu?Met?Arg?Leu?His?Thr?Glu

150 155 160 165

atc?acg?gac?tcc?acc?aca?ggg?cga?ctc?gtg?ctc?ttg?gat?aat?tta?ctg 643

Ile?Thr?Asp?Ser?Thr?Thr?Gly?Arg?Leu?Val?Leu?Leu?Asp?Asn?Leu?Leu

170 175 180

ctc?cgg?ccg?gac?tcc?cga?gag?gga?agt?ttt?ggg?tgg?acg?gaa?cag?tac 691

Leu?Arg?Pro?Asp?Ser?Arg?Glu?Gly?Ser?Phe?Gly?Trp?Thr?Glu?Gln?Tyr

185 190 195

aca?cat?tca?ggg?cag?atg?att?gtg?atg?ggg?gaa?ggc?gtc?gat?aag?cag 739

Thr?His?Ser?Gly?Gln?Met?Ile?Val?Met?Gly?Glu?Gly?Val?Asp?Lys?Gln

200 205 210

ctt?gtt?gct?gag?ctg?aat?gag?caa?ctt?gcc?gcg?cac?cct?gat?gtg?tac 787

Leu?Val?Ala?Glu?Leu?Asn?Glu?Gln?Leu?Ala?Ala?His?Pro?Asp?Val?Tyr

215 220 225

ggc?gcc?gtc?aat?ttc?tta?agc?gcg?ccg?ggc?acg?tta?ctg?cgc?gga?ttt 835

Gly?Ala?Val?Asn?Phe?Leu?Ser?Ala?Pro?Gly?Thr?Leu?Leu?Arg?Gly?Phe

230 235 240 245

att?gcg?cgc?acg?ctg?agc?aac?cgc?act?gag?gag?ttg?att?aac?ctg?cac 883

Ile?Ala?Arg?Thr?Leu?Ser?Asn?Arg?Thr?Glu?Glu?Leu?Ile?Asn?Leu?His

250 255 260

gaa?cac?att?gcg?tcg?ctg?ttg?cgc?ggg?cgg?tgg?cgc?ggg?cag?gaa?ccg 931

Glu?His?Ile?Ala?Ser?Leu?Leu?Arg?Gly?Arg?Trp?Arg?Gly?Gln?Glu?Pro

265 270 275

gtg?aat?ttg?cgg?aag?tac?tagacggcgt?cgagaaatcg?aag 972

Val?Asn?Leu?Arg?Lys?Tyr

280

<210>20

<211>283

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>20

Met?Thr?Gln?Thr?Gln?Pro?Val?Gly?Thr?Leu?Arg?Leu?Thr?Ile?Asp?Asp

1 5 10 15

Gln?Gly?Pro?Gln?Gly?Gln?Ser?Arg?Ala?Val?Glu?Gln?Phe?His?Gln?Gly

20 25 30

Ala?Leu?Arg?Val?Ile?Arg?Pro?His?Tyr?Leu?Asp?Asp?Ser?Gly?Gln?Val

35 40 45

Cys?Tyr?Thr?Ile?Ile?Ala?Ile?Gly?Gly?Gly?Tyr?Leu?Gly?Gly?Asp?Val

50 55 60

Tyr?Glu?Gln?Gln?Phe?Thr?Ile?Lys?Asp?Asn?Ala?Lys?Ala?Leu?Ile?Thr

65 70 75 80

Thr?Gln?Ser?Ala?Thr?Lys?Ile?Tyr?Arg?Thr?Pro?Gln?Gly?Pro?Ala?Thr

85 90 95

Gln?His?Thr?Glu?Ile?Asn?Val?Gly?Glu?Asn?Ala?Val?Leu?Glu?Tyr?Leu

100 105 110

Ala?Asp?Gln?Thr?Ile?Ala?Tyr?Arg?Glu?Ala?Thr?Tyr?His?Gln?Phe?Thr

115 120 125

Lys?Val?Ala?Leu?His?Pro?Ser?Ala?Thr?Phe?Val?Met?Ser?Glu?Gln?Ile

130 135 140

Thr?Pro?Gly?Trp?His?Pro?Asp?Gly?Lys?His?Phe?Ala?Tyr?Asp?Glu?Met

145 150 155 160

Arg?Leu?His?Thr?Glu?Ile?Thr?Asp?Ser?Thr?Thr?Gly?Arg?Leu?Val?Leu

165 170 175

Leu?Asp?Asn?Leu?Leu?Leu?Arg?Pro?Asp?Ser?Arg?Glu?Gly?Ser?Phe?Gly

180 185 190

Trp?Thr?Glu?Gln?Tyr?Thr?His?Ser?Gly?Gln?Met?Ile?Val?Met?Gly?Glu

195 200 205

Gly?Val?Asp?Lys?Gln?Leu?Val?Ala?Glu?Leu?Asn?Glu?Gln?Leu?Ala?Ala

210 215 220

His?Pro?Asp?Val?Tyr?Gly?Ala?Val?Asn?Phe?Leu?Ser?Ala?Pro?Gly?Thr

225 230 235 240

Leu?Leu?Arg?Gly?Phe?Ile?Ala?Arg?Thr?Leu?Ser?Asn?Arg?Thr?Glu?Glu

245 250 255

Leu?Ile?Asn?Leu?His?Glu?His?Ile?Ala?Ser?Leu?Leu?Arg?Gly?Arg?Trp

260 265 270

Arg?Gly?Gln?Glu?Pro?Val?Asn?Leu?Arg?Lys?Tyr

275 280

<210>21

<211>594

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(571)

<223>RXA02275

<400>21

gtttgtcaac?ggtgagttga?tcaccagcaa?gccagcagag?acagtgccaa?tggcacgtcg?60

ctacttcttg?ttctaatccg?ccaacaagga?aggaagatcc?atg?att?atc?act?gcg 115

Met?Ile?Ile?Thr?Ala

1 5

atc?gac?acc?aac?atc?tac?gat?gaa?ccg?gag?ttt?gtt?gaa?gga?cgc?gat 163

Ile?Asp?Thr?Asn?Ile?Tyr?Asp?Glu?Pro?Glu?Phe?Val?Glu?Gly?Arg?Asp

10 15 20

gtc?atc?ggt?gtg?cgc?ttt?gaa?gat?tta?gtt?ttg?gat?aag?cgc?att?caa 211

Val?Ile?Gly?Val?Arg?Phe?Glu?Asp?Leu?Val?Leu?Asp?Lys?Arg?Ile?Gln

25 30 35

cgg?gtt?gca?ctc?ccc?gga?gga?gaa?gaa?ctg?ggg?ttg?cgg?tta?aac?cac 259

Arg?Val?Ala?Leu?Pro?Gly?Gly?Glu?Glu?Leu?Gly?Leu?Arg?Leu?Asn?His

40 45 50

ggg?cat?ccg?att?ctg?cgt?gaa?ggt?gat?gtg?ttg?aaa?gct?gat?gat?aag 307

Gly?His?Pro?Ile?Leu?Arg?Glu?Gly?Asp?Val?Leu?Lys?Ala?Asp?Asp?Lys

55 60 65

acg?gta?ttt?gtg?gtg?gag?att?atc?ccc?acg?gat?gtt?tta?gtt?atc?acg 355

Thr?Val?Phe?Val?Val?Glu?Ile?Ile?Pro?Thr?Asp?Val?Leu?Val?Ile?Thr

70 75 80 85

cca?agc?gat?att?cac?cag?atg?gga?ttt?gtg?gcg?cac?tcc?ctg?gga?aac 403

Pro?Ser?Asp?Ile?His?Gln?Met?Gly?Phe?Val?Ala?His?Ser?Leu?Gly?Asn

90 95 100

agg?cac?ctg?cca?gca?cag?ttt?tcc?aag?cca?ggt?gaa?ttg?aca?gag?aag 451

Arg?His?Leu?Pro?Ala?Gln?Phe?Ser?Lys?Pro?Gly?Glu?Leu?Thr?Glu?Lys

105 110 115

gca?gcc?atg?atc?gtg?caa?tac?gat?cac?acg?gtg?gtc?agc?ttc?ttg?gat 499

Ala?Ala?Met?Ile?Val?Gln?Tyr?Asp?His?Thr?Val?Val?Ser?Phe?Leu?Asp

120 125 130

gag?cac?ggc?arc?gag?tat?cag?cgc?acc?gaa?ctt?gtt?ccg?cca?att?cct 547

Glu?His?Gly?Ile?Glu?Tyr?Gln?Arg?Thr?Glu?Leu?Val?Pro?Pro?Ile?Pro

135 140 145

ttc?agg?cat?agc?ggg?cac?aca?cat?tgatggatct?tgacgctgat?ttt 594

Phe?Arg?His?Ser?Gly?His?Thr?His

150 155

<210>22

<211>157

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>22

Met?Ile?Ile?Thr?Ala?Ile?Asp?Thr?Asn?Ile?Tyr?Asp?Glu?Pro?Glu?Phe

1 5 10 15

Val?Glu?Gly?Arg?Asp?Val?Ile?Gly?Val?Arg?Phe?Glu?Asp?Leu?Val?Leu

20 25 30

Asp?Lys?Arg?Ile?Gln?Arg?Val?Ala?Leu?Pro?Gly?Gly?Glu?Glu?Leu?Gly

35 40 45

Leu?Arg?Leu?Asn?His?Gly?His?Pro?Ile?Leu?Arg?Glu?Gly?Asp?Val?Leu

50 55 60

Lys?Ala?Asp?Asp?Lys?Thr?Val?Phe?Val?Val?Glu?Ile?Ile?Pro?Thr?Asp

65 70 75 80

Val?Leu?Val?Ile?Thr?Pro?Ser?Asp?Ile?His?Gln?Met?Gly?Phe?Val?Ala

85 90 95

His?Ser?Leu?Gly?Asn?Arg?His?Leu?Pro?Ala?Gln?Phe?Ser?Lys?Pro?Gly

100 105 110

Glu?Leu?Thr?Glu?Lys?Ala?Ala?Met?Ile?Val?Gln?Tyr?Asp?His?Thr?Val

115 120 125

Val?Ser?Phe?Leu?Asp?Glu?His?Gly?Ile?Glu?Tyr?Gln?Arg?Thr?Glu?Leu

130 135 140

Val?Pro?Pro?Ile?Pro?Phe?Arg?His?Ser?Gly?His?Thr?His

145 150 155

<210>23

<211>801

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(778)

<223>RXA02276

<400>23

atcacacggt?ggtcagcttc?ttggatgagc?acggcatcga?gtatcagcgc?accgaacttg?60

ttccgccaat?tcctttcagg?catagcgggc?acacacattg?atg?gat?ctt?gac?gct 115

Met?Asp?Leu?Asp?Ala

1 5

gat?ttt?ctg?ctg?ttg?cat?tta?tcg?gat?tca?gca?ctt?cca?acg?gga?gcg 163

Asp?Phe?Leu?Leu?Leu?His?Leu?Ser?Asp?Ser?Ala?Leu?Pro?Thr?Gly?Ala

10 15 20

ttt?gcg?cac?tca?ttt?gga?ttt?gaa?act?tat?atg?gat?gca?gag?cga?atc 211

Phe?Ala?His?Ser?Phe?Gly?Phe?Glu?Thr?Tyr?Met?Asp?Ala?Glu?Arg?Ile

25 30 35

acc?aat?gca?gag?gag?ttc?caa?gac?tgg?ctg?aaa?gtc?ctg?ctt?aag?gtg 259

Thr?Asn?Ala?Glu?Glu?Phe?Gln?Asp?Trp?Leu?Lys?Val?Leu?Leu?Lys?Val

40 45 50

caa?ttg?acc?agc?tct?gat?gct?ttg?gca?atg?agg?atg?ttt?tac?gcc?acc 307

Gln?Leu?Thr?Ser?Ser?Asp?Ala?Leu?Ala?Met?Arg?Met?Phe?Tyr?Ala?Thr

55 60 65

ccg?acg?gtg?tct?gag?ctg?aaa?cgg?ctg?gat?gag?cgc?ctt?ttt?gct?gga 355

Pro?Thr?Val?Ser?Glu?Leu?Lys?Arg?Leu?Asp?Glu?Arg?Leu?Phe?Ala?Gly

70 75 80 85

act?ccg?gcg?aga?gaa?att?cgg?gaa?gct?aat?gct?cga?atg?ggt?acg?cgc 403

Thr?Pro?Ala?Arg?Glu?Ile?Arg?Glu?Ala?Asn?Ala?Arg?Met?Gly?Thr?Arg

90 95 100

atg?gca?gag?atc?gtg?gct?gaa?acc?tac?tcc?gtg?ccc?ctg?att?gtt?gag 451

Met?Ala?Glu?Ile?Val?Ala?Glu?Thr?Tyr?Ser?Val?Pro?Leu?Ile?Val?Glu

105 110 115

tat?ctc?gaa?ttg?att?caa?cat?cga?gag?cta?rca?ggg?cac?ccg?gct?ttg 499

Tyr?Leu?Glu?Leu?Ile?Gln?His?Arg?Glu?Leu?Ser?Gly?His?Pro?Ala?Leu

120 125 130

gct?ttg?gct?ctt?gcc?acc?cac?agc?gcg?ggg?att?gat?gtg?gat?cga?gca 547

Ala?Leu?Ala?Leu?Ala?Thr?His?Ser?Ala?Gly?Ile?Asp?Val?Asp?Arg?Ala

135 140 145

atc?cac?gct?cac?ctc?acg?gca?acg?gtg?agt?tcg?ctg?atc?caa?aat?gcg 595

Ile?His?Ala?His?Leu?Thr?Ala?Thr?Val?Ser?Ser?Leu?Ile?Gln?Asn?Ala

150 155 160 165

gtt?cgt?ggc?atc?cca?ctg?ggg?caa?atg?gca?ggt?cag?cgg?gtg?atg?ttc 643

Val?Arg?Gly?Ile?Pro?Leu?Gly?Gln?Met?Ala?Gly?Gln?Arg?Val?Met?Phe

170 175 180

gcc?atg?cgt?gag?cat?atc?ggt?gcg?gcc?gtg?aaa?cgt?agc?gcg?aac?ttg 691

Ala?Met?Arg?Glu?His?Ile?Gly?Ala?Ala?Val?Lys?Arg?Ser?Ala?Asn?Leu

185 190 195

gat?gag?att?gat?ttc?tgt?tcg?ggt?gat?cca?ggc?ttg?gat?att?tca?caa 739

Asp?Glu?Ile?Asp?Phe?Cys?Ser?Gly?Asp?Pro?Gly?Leu?Asp?Ile?Ser?Gln

200 205 210

atg?gtt?cat?gaa?acc?caa?cgc?gca?cga?cta?ttt?atg?agt?taagaaggag 788

Met?Val?His?Glu?Thr?Gln?Arg?Ala?Arg?Leu?Phe?Met?Ser

215 220 225

aaaagaaaca?tgg 801

<2l0>24

<211>226

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacter ium glutamicum)

<400>24

Met?Asp?Leu?Asp?Ala?Asp?Phe?Leu?Leu?Leu?His?Leu?Ser?Asp?Ser?Ala

1 5 10 15

Leu?Pro?Thr?Gly?Ala?Phe?Ala?His?Ser?Phe?Gly?Phe?Glu?Thr?Tyr?Met

20 25 30

Asp?Ala?Glu?Arg?Ile?Thr?Asn?Ala?Glu?Glu?Phe?Gln?Asp?Trp?Leu?Lys

35 40 45

Val?Leu?Leu?Lys?Val?Gln?Leu?Thr?Ser?Ser?Asp?Ala?Leu?Ala?Met?Arg

50 55 60

Met?Phe?Tyr?Ala?Thr?Pro?Thr?Val?Ser?Glu?Leu?Lys?Arg?Leu?Asp?Glu

65 70 75 80

Arg?Leu?Phe?Ala?Gly?Thr?Pro?Ala?Arg?Glu?Ile?Arg?Glu?Ala?Asn?Ala

85 90 95

Arg?Met?Gly?Thr?Arg?Met?Ala?Glu?Ile?Val?Ala?Glu?Thr?Tyr?Ser?Val

100 105 110

Pro?Leu?Ile?Val?Glu?Tyr?Leu?Glu?Leu?Ile?Gln?His?Arg?Glu?Leu?Ser

115 120 125

Gly?His?Pro?Ala?Leu?Ala?Leu?Ala?Leu?Ala?Thr?His?Ser?Ala?Gly?Ile

130 135 140

Asp?Val?Asp?Arg?Ala?Ile?His?Ala?His?Leu?Thr?Ala?Thr?Val?Ser?Ser

145 150 155 160

Leu?Ile?Gln?Asn?Ala?Val?Arg?Gly?Ile?Pro?Leu?Gly?Gln?Met?Ala?Gly

165 170 175

Gln?Arg?Val?Met?Phe?Ala?Met?Arg?Glu?His?Ile?Gly?Ala?Ala?Val?Lys

180 185 190

Arg?Ser?Ala?Asn?Leu?Asp?Glu?Ile?Asp?Phe?Cys?Ser?Gly?Asp?Pro?Gly

195 200 205

Leu?Asp?Ile?Ser?Gln?Met?Val?His?Glu?Thr?Gln?Arg?Ala?Arg?Leu?Phe

210 215 220

Met?Ser

225

<210>25

<211>738

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(715)

<223>RXA02277

<400>25

attgatttct?gttcgggtga?tccaggcttg?gatatttcac?aaatggttca?tgaaacccaa?60

cgcgcacgac?tatttatgag?ttaagaagga?gaaaagaaac?atg?ggt?cea?atc?aga 115

Met?Gly?Pro?Ile?Arg

1 5

atc?ggc?gta?ggc?ggg?ccg?gtc?ggc?gcc?gga?aaa?acg?cag?ctg?gta?gag 163

Ile?Gly?Val?Gly?Gly?Pro?Val?Gly?Ala?Gly?Lys?Thr?Gln?Leu?Val?Glu

10 15 20

cgg?att?acg?cga?gcg?ctt?atc?gac?gaa?gtc?agc?atg?gct?gca?atc?act 211

Arg?Ile?Thr?Arg?Ala?Leu?Ile?Asp?Glu?Val?Ser?Met?Ala?Ala?Ile?Thr

25 30 35

aac?gat?atc?tac?acc?att?gaa?gac?gcc?aag?att?ctt?gcc?gcc?aat?gga 259

Asn?Asp?Ile?Tyr?Thr?Ile?Glu?Asp?Ala?Lys?Ile?Leu?Ala?Ala?Asn?Gly

40 45 50

gtg?ctg?cca?gaa?gaa?cgc?att?gtt?ggc?att?gaa?act?gga?gga?tgc?cca 307

Val?Leu?Pro?Glu?Glu?Arg?Ile?Val?Gly?Ile?Glu?Thr?Gly?Gly?Cys?Pro

55 60 65

cac?act?gcg?att?cgt?gaa?gac?acc?tcc?atg?aat?gat?gca?gcg?atc?aaa 355

His?Thr?Ala?Ile?Arg?Glu?Asp?Thr?Ser?Met?Asn?Asp?Ala?Ala?Ile?Lys

70 75 80 85

gac?ctt?gtg?gaa?cgc?ttc?cca?gat?ctg?gaa?ctc?atc?ttt?gtg?gaa?tct 403

Asp?Leu?Val?Glu?Arg?Phe?Pro?Asp?Leu?Glu?Leu?Ile?Phe?Val?Glu?Ser

90 95 100

ggt?gga?gat?aat?ctc?tct?gca?acg?ttc?tcg?cca?gag?ctg?gtg?gat?ttt 451

Gly?Gly?Asp?Asn?Leu?Ser?Ala?Thr?Phe?Ser?Pro?Glu?Leu?Val?Asp?Phe

105 110 115

tcc?atc?tac?atc?atc?gat?gtt?gcc?caa?ggt?gag?aag?atc?ccg?agg?aaa 499

Ser?Ile?Tyr?Ile?Ile?Asp?Val?Ala?Gln?Gly?Glu?Lys?Ile?Pro?Arg?Lys

120 125 130

gct?ggc?caa?ggc?atg?att?aag?tcg?gat?ttg?ttt?atc?att?aat?aaa?act 547

Ala?Gly?Gln?Gly?Met?Ile?Lys?Ser?Asp?Leu?Phe?Ile?Ile?Asn?Lys?Thr

135 140 145

gac?ctt?gcc?cca?tat?gtt?ggt?gcc?aac?cta?gat?gtc?atg?gtg?gaa?gat 595

Asp?Leu?Ala?Pro?Tyr?Val?Gly?Ala?Asn?Leu?Asp?Val?Met?Val?Glu?Asp

150 155 160 165

gcc?aaa?gca?ttc?cgc?aag?aac?aaa?cca?ttc?tgc?ctg?act?aat?ctg?cgc 643

Ala?Lys?Ala?Phe?Arg?Lys?Asn?Lys?Pro?Phe?Cys?Leu?Thr?Asn?Leu?Arg

170 175 180

acc?gat?gat?ggt?ttg?gat?aag?gtc?ttg?gaa?tgg?atc?cgc?cat?gag?gtg 691

Thr?Asp?Asp?Gly?Leu?Asp?Lys?Val?Leu?Glu?Trp?Ile?Arg?His?Glu?Val

185 190 195

atg?atg?cag?gac?ttg?cag?gaa?gcc?taaatgacac?aaacccaacc?agt 738

Met?Met?Gln?Asp?Leu?Gln?Glu?Ala

200 205

<210>26

<211>205

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>26

Met?Gly?Pro?Ile?Arg?Ile?Gly?Val?Gly?Gly?Pro?Val?Gly?Ala?Gly?Lys

1 5 10 15

Thr?Gln?Leu?Val?Glu?Arg?Ile?Thr?Arg?Ala?Leu?Ile?Asp?Glu?Val?Ser

20 25 30

Met?Ala?Ala?Ile?Thr?Asn?Asp?Ile?Tyr?Thr?Ile?Glu?Asp?Ala?Lys?Ile

35 40 45

Leu?Ala?Ala?Asn?Gly?Val?Leu?Pro?Glu?Glu?Arg?Ile?Val?Gly?Ile?Glu

50 55 60

Thr?Gly?Gly?Cys?Pro?His?Thr?Ala?Ile?Arg?Glu?Asp?Thr?Ser?Met?Asn

65 70 75 80

Asp?Ala?Ala?Ile?Lys?Asp?Leu?Val?Glu?Arg?Phe?Pro?Asp?Leu?Glu?Leu

85 90 95

Ile?Phe?Val?Glu?Ser?Gly?Gly?Asp?Asn?Leu?Ser?Ala?Thr?Phe?Ser?Pro

100 105 110

Glu?Leu?Val?Asp?Phe?Ser?Ile?Tyr?Ile?Ile?Asp?Val?Ala?Gln?Gly?Glu

115 120 125

Lys?Ile?Pro?Arg?Lys?Ala?Gly?Gln?Gly?Met?Ile?Lys?Ser?Asp?Leu?Phe

130 135 140

Ile?Ile?Asn?Lys?Thr?Asp?Leu?Ala?Pro?Tyr?Val?Gly?Ala?Asn?Leu?Asp

145 150 155 160

Val?Met?Val?Glu?Asp?Ala?Lys?Ala?Phe?Arg?Lys?Asn?Lys?Pro?Phe?Cys

165 170 175

Leu?Thr?Asn?Leu?Arg?Thr?Asp?Asp?Gly?Leu?Asp?Lys?Val?Leu?Glu?Trp

180 185 190

Ile?Arg?His?Glu?Val?Met?Met?Gln?Asp?Leu?Gln?Glu?Ala

195 200 205

<210>27

<211>1119

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1096)

<223>RXA02603

<400>27

gcatggtgct?tggcgtgcat?tacccaaccg?atgtgctagc?cggcgcgttg?ttgggagcag?60

cgaccgcaga?ggccgtccat?aagatcgaaa?gggctacgaa?gtg?agc?gaa?cac?gcc 115

Val?Ser?Glu?His?Ala

1 5

gct?gaa?cat?cac?cgc?gat?acc?caa?aat?ttc?tta?acc?tcc?gaa?ccg?cac 163

Ala?Glu?His?His?Arg?Asp?Thr?Gln?Asn?Phe?Leu?Thr?Ser?Glu?Pro?His

10 15 20

acc?acg?gca?atc?gaa?gac?aac?aag?aag?cgc?caa?ccg?ccg?aaa?aac?ctt 211

Thr?Thr?Ala?Ile?Glu?Asp?Asn?Lys?Lys?Arg?Gln?Pro?Pro?Lys?Asn?Leu

25 30 35

gct?gac?ggc?atg?atc?aag?gcg?ctg?cgc?ccc?aag?cag?tgg?gtc?aag?aac 259

Ala?Asp?Gly?Met?Ile?Lys?Ala?Leu?Arg?Pro?Lys?Gln?Trp?Val?Lys?Asn

40 45 50

gtt?ctt?gtg?cta?gca?gca?cca?ctt?gct?gct?ggt?gca?gat?gcg?atc?ttc 307

Val?Leu?Val?Leu?Ala?Ala?Pro?Leu?Ala?Ala?Gly?Ala?Asp?Ala?Ile?Phe

55 60 65

aac?cag?cgc?acg?atc?atc?gac?gtt?gct?atc?gca?ttc?gta?gtg?ttc?tgc 355

Asn?Gln?Arg?Thr?Ile?Ile?Asp?Val?Ala?Ile?Ala?Phe?Val?Val?Phe?Cys

70 75 80 85

ttc?ggt?gca?tca?gcc?att?tac?ttg?gtt?aat?gat?gcc?cgt?gac?gtg?gaa 403

Phe?Gly?Ala?Ser?Ala?Ile?Tyr?Leu?Val?Asn?Asp?Ala?Arg?Asp?Val?Glu

90 95 100

gct?gac?cgc?gag?cac?cca?acc?aag?cgt?ttc?cgc?ccc?atc?gct?gca?gga 451

Ala?Asp?Arg?Glu?His?Pro?Thr?Lys?Arg?Phe?Arg?Pro?Ile?Ala?Ala?Gly

105 110 115

gtc?ctg?cca?gta?gga?atg?gca?tac?ggc?atg?gcc?gtg?gcg?ctc?att?gca 499

Val?Leu?Pro?Val?Gly?Met?Ala?Tyr?Gly?Met?Ala?Val?Ala?Leu?Ile?Ala

120 125 130

cta?tcc?atc?gga?ctg?tct?ttc?ctc?gcc?acc?gac?ggc?gtg?gca?ctt?gcc 547

Leu?Ser?Ile?Gly?Leu?Ser?Phe?Leu?Ala?Thr?Asp?Gly?Val?Ala?Leu?Ala

135 140 145

tgc?gtg?att?ggc?gtg?tac?att?gcg?ctg?cag?ctg?gga?tac?tgc?ttc?ggt 595

Cys?Val?Ile?Gly?Val?Tyr?Ile?Ala?Leu?Gln?Leu?Gly?Tyr?Cys?Phe?Gly

150 155 160 165

tgg?aag?cac?atg?cca?gtg?atc?gat?att?gcg?ctt?gtc?tcc?tcc?gga?ttc 643

Trp?Lys?His?Met?Pro?Val?Ile?Asp?Ile?Ala?Leu?Val?Ser?Ser?Gly?Phe

170 175 180

atg?ctc?cgc?gca?atg?gca?ggt?ggt?gtc?gca?gca?ggc?atc?gag?cta?tcc 691

Met?Leu?Arg?Ala?Met?Ala?Gly?Gly?Val?Ala?Ala?Gly?Ile?Glu?Leu?Ser

185 190 195

cag?tgg?ttc?ctg?cta?gtc?gct?gcg?ttt?ggt?tcc?ctg?ttc?atg?gca?tct 739

Gln?Trp?Phe?Leu?Leu?Val?Ala?Ala?Phe?Gly?Ser?Leu?Phe?Met?Ala?Ser

200 205 210

gga?aag?cgc?tac?gca?gaa?atc?ctt?ctg?cac?gag?cgc?acc?ggc?gct?aag 787

Gly?Lys?Arg?Tyr?Ala?Glu?Ile?Leu?Leu?His?Glu?Arg?Thr?Gly?Ala?Lys

215 220 225

atc?cgc?aag?tcc?ctg?gaa?agc?tac?acc?ccc?acc?tac?ctg?cgc?ttc?gtt 835

Ile?Arg?Lys?Ser?Leu?Glu?Ser?Tyr?Thr?Pro?Thr?Tyr?Leu?Arg?Phe?Val

230 235 240 245

tgg?acc?atg?gca?gca?aca?gca?gtg?gtc?atg?tcc?tac?gca?ctg?tgg?ggc 883

Trp?Thr?Met?Ala?Ala?Thr?Ala?Val?Val?Met?Ser?Tyr?Ala?Leu?Trp?Gly

250 255 260

ttc?gac?ctt?tcc?caa?cac?tcc?acc?gac?gca?ggt?ccg?tgg?tac?caa?atc 931

Phe?Asp?Leu?Ser?Gln?His?Ser?Thr?Asp?Ala?Gly?Pro?Trp?Tyr?Gln?Ile

265 270 275

tcc?atg?gtt?cca?ttc?acc?atc?gcc?atc?ctg?cgc?tac?gca?gcc?ggc?gta 979

Ser?Met?Val?Pro?Phe?Thr?Ile?Ala?Ile?Leu?Arg?Tyr?Ala?Ala?Gly?Val

280 285 290

gac?acc?ggc?gac?ggc?ggt?gcc?cct?gac?gaa?gtg?gca?ctc?agc?gac?aaa 1027

Asp?Thr?Gly?Asp?Gly?Gly?Ala?Pro?Asp?Glu?Val?AIa?Leu?Ser?Asp?Lys

295 300 305

gtt?ctg?cag?gta?cta?gcc?cta?gca?tgg?gtt?ttc?tgc?atc?gtg?atg?gct 1075

Val?Leu?Gln?Val?Leu?Ala?Leu?Ala?Trp?Val?Phe?Cys?Ile?Val?Met?Ala

310 315 320 325

gtg?tac?atc?atg?ccg?atg?ttt?tgaatattta?ccaatgaaca?tgc 1119

Val?Tyr?Ile?Met?Pro?Met?Phe

330

<210>28

<211>332

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>28

Val?Ser?Glu?His?Ala?Ala?Glu?His?His?Arg?Asp?Thr?Gln?Asn?Phe?Leu

1 5 10 15

Thr?Ser?Glu?Pro?His?Thr?Thr?Ala?Ile?Glu?Asp?Asn?Lys?Lys?Arg?Gln

20 25 30

Pro?Pro?Lys?Asn?Leu?Ala?Asp?Gly?Met?Ile?Lys?Ala?Leu?Arg?Pro?Lys

35 40 45

Gln?Trp?Val?Lys?Asn?Val?Leu?Val?Leu?Ala?Ala?Pro?Leu?Ala?Ala?Gly

50 55 60

Ala?Asp?Ala?Ile?Phe?Asn?Gln?Arg?Thr?Ile?Ile?Asp?Val?Ala?Ile?Ala

65 70 75 80

Phe?Val?Val?Phe?Cys?Phe?Gly?Ala?Ser?Ala?Ile?Tyr?Leu?Val?Asn?Asp

85 90 95

Ala?Arg?Asp?Val?Glu?Ala?Asp?Arg?Glu?His?Pro?Thr?Lys?Arg?Phe?Arg

100 105 110

Pro?Ile?Ala?Ala?Gly?Val?Leu?Pro?Val?Gly?Met?Ala?Tyr?Gly?Met?Ala

115 120 125

Val?Ala?Leu?Ile?Ala?Leu?Ser?Ile?Gly?Leu?Ser?Phe?Leu?Ala?Thr?Asp

130 135 140

Gly?Val?Ala?Leu?Ala?Cys?Val?Ile?Gly?Val?Tyr?Ile?Ala?Leu?Gln?Leu

145 150 155 160

Gly?Tyr?Cys?Phe?Gly?Trp?Lys?His?Met?Pro?Val?Ile?Asp?Ile?Ala?Leu

165 170 175

Val?Ser?Ser?Gly?Phe?Met?Leu?Arg?Ala?Met?Ala?Gly?Gly?Val?Ala?Ala

180 185 190

Gly?Ile?Glu?Leu?Ser?Gln?Trp?Phe?Leu?Leu?Val?Ala?Ala?Phe?Gly?Ser

195 200 205

Leu?Phe?Met?Ala?Ser?Gly?Lys?Arg?Tyr?Ala?Glu?Ile?Leu?Leu?His?Glu

210 215 220

Arg?Thr?Gly?Ala?Lys?Ile?Arg?Lys?Ser?Leu?Glu?Ser?Tyr?Thr?Pro?Thr

225 230 235 240

Tyr?Leu?Arg?Phe?Val?Trp?Thr?Met?Ala?Ala?Thr?Ala?Val?Val?Met?Ser

245 250 255

Tyr?Ala?Leu?Trp?Gly?Phe?Asp?Leu?Ser?Gln?His?Ser?Thr?Asp?Ala?Gly

260 265 270

Pro?Trp?Tyr?Gln?Ile?Ser?Met?Val?Pro?Phe?Thr?Ile?Ala?Ile?Leu?Arg

275 280 285

Tyr?Ala?Ala?Gly?Val?Asp?Thr?Gly?Asp?Gly?Gly?Ala?Pro?Asp?Glu?Val

290 295 300

Ala?Leu?Ser?Asp?Lys?Val?Leu?Gln?Val?Leu?Ala?Leu?Ala?Trp?Val?Phe

305 310 315 320

Cys?Ile?Val?Met?Ala?Val?Tyr?Ile?Met?Pro?Met?Phe

325 330

<210>29

<211>2004

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1981)

<223>RXA01385

<400>29

atcacacttt?cattcgcagt?gtgatctgaa?ctacatttct?ggttactgta?cggaacacgc?60

tccgtgaatg?agataggaaa?tcccctcgaa?aggaccagac?atg?cag?ttt?cat?tat 115

Met?Gln?Phe?His?Tyr

1 5

gaa?gga?tac?gca?acc?ggt?gac?cca?atg?gag?atg?cgc?gcg?gaa?ggt?agc 163

Glu?Gly?Tyr?Ala?Thr?Gly?Asp?Pro?Met?Glu?Met?Arg?Ala?Glu?Gly?Ser

10 15 20

gga?atc?aac?cgc?ccg?gac?gat?ctc?ccc?gag?gtc?atg?gat?gtt?ctc?atc 211

Gly?Ile?Asn?Arg?Pro?Asp?Asp?Leu?Pro?Glu?Val?Met?Asp?Val?Leu?Ile

25 30 35

gtt?ggt?gca?ggt?ccg?gct?ggc?acc?atc?gca?gcg?gct?cag?ctt?tcc?cga 259

Val?Gly?Ala?Gly?Pro?Ala?Gly?Thr?Ile?Ala?Ala?Ala?Gln?Leu?Ser?Arg

40 45 50

ttc?ccc?aat?gtg?acc?acc?cgc?ctc?gta?gag?aga?agc?gac?cgt?cgc?ctc 307

Phe?Pro?Asn?Val?Thr?Thr?Arg?Leu?Val?Glu?Arg?Ser?Asp?Arg?Arg?Leu

55 60 65

gaa?cta?gcc?aat?gca?gat?ggc?gtg?cac?tcc?cga?acc?att?gaa?act?ttc 355

Glu?Leu?Ala?Asn?Ala?Asp?Gly?Val?His?Ser?Arg?Thr?Ile?Glu?Thr?Phe

70 75 80 85

cag?gca?ttt?ggt?ttc?gcc?cac?gag?atc?ctc?gcc?gaa?gct?cat?gaa?atc 403

Gln?Ala?Phe?Gly?Phe?Ala?His?Glu?Ile?Leu?Ala?Glu?Ala?His?Glu?Ile

90 95 100

acc?gac?atg?gcg?ttc?tgg?aag?ccg?gac?ccg?caa?aac?cct?cgt?gag?atc 451

Thr?Asp?Met?Ala?Phe?Trp?Lys?Pro?Asp?Pro?Gln?Asn?Pro?Arg?Glu?Ile

105 110 115

att?cgc?gac?aac?agc?acc?cgc?gag?ctg?cca?cag?cac?atc?agt?gaa?ttt 499

Ile?Arg?Asp?Asn?Ser?Thr?Arg?Glu?Leu?Pro?Gln?His?Ile?Ser?Glu?Phe

120 125 130

ccg?atg?gcg?ttg?ctc?acc?cag?acc?cgc?atc?atc?gac?cac?ttc?aac?cgg 547

Pro?Met?Ala?Leu?Leu?Thr?Gln?Thr?Arg?Ile?Ile?Asp?His?Phe?Asn?Arg

135 140 145

ttc?atg?aag?aac?tcc?cca?acc?agg?atg?aag?cct?gac?tat?gga?tac?gag 595

Phe?Met?Lys?Asn?Ser?Pro?Thr?Arg?Met?Lys?Pro?Asp?Tyr?Gly?Tyr?Glu

150 155 160 165

ttc?gtg?gac?ttt?gaa?gta?gaa?gaa?gac?gca?gaa?tat?ccg?gta?att?gtc 643

Phe?Val?Asp?Phe?Glu?Val?Glu?Glu?Asp?Ala?Glu?Tyr?Pro?Val?Ile?Val

170 175 180

acc?ctc?cgc?cgc?acc?agt?ggc?gag?caa?act?ggc?gaa?ttg?gtc?acc?gtc 691

Thr?Leu?Arg?Arg?Thr?Ser?Gly?Glu?Gln?Thr?Gly?Glu?Leu?Val?Thr?Val

185 190 195

cga?acc?aag?tac?ctg?gtc?ggt?gcc?gat?ggt?gca?cga?agc?caa?gtg?cgc 739

Arg?Thr?Lys?Tyr?Leu?Val?Gly?Ala?Asp?Gly?Ala?Arg?Ser?Gln?Val?Arg

200 205 210

aaa?tca?ctg?gga?tac?cga?ctc?caa?ggt?aag?cag?gct?aac?cac?gct?tgg 787

Lys?Ser?Leu?Gly?Tyr?Arg?Leu?Gln?Gly?Lys?Gln?Ala?Asn?His?Ala?Trp

215 220 225

ggt?gtg?atg?gat?att?cac?gcg?aac?acc?gag?ttc?ccc?gac?gtg?cgc?aag 835

Gly?Val?Met?Asp?Ile?His?Ala?Asn?Thr?Glu?Phe?Pro?Asp?Val?Arg?Lys

230 235 240 245

aag?tgc?acc?atc?aaa?tct?gat?tcg?ggt?cgc?acc?atc?ttg?ctc?atc?cca 883

Lys?Cys?Thr?Ile?Lys?Ser?Asp?Ser?Gly?Arg?Thr?Ile?Leu?Leu?Ile?Pro

250 255 260

cgt?gag?ggt?ggc?ttc?ctc?ttc?cgt?ctc?tac?gtt?gac?ctg?ggc?gaa?gta 931

Arg?Glu?Gly?Gly?Phe?Leu?Phe?Arg?Leu?Tyr?Val?Asp?Leu?Gly?Glu?Val

265 270 275

cct?gat?gat?ggc?agc?aag?gct?gtt?cgt?gat?acc?cca?ctc?cag?gat?gtc 979

Pro?Asp?Asp?Gly?Ser?Lys?Ala?Val?Arg?Asp?Thr?Pro?Leu?Gln?Asp?Val

280 285 290

atc?gac?acc?gcg?aac?cag?atc?atg?gct?cca?ttc?acc?ctc?gac?gtg?aaa 1027

Ile?Asp?Thr?Ala?Asn?Gln?Ile?Met?Ala?Pro?Phe?Thr?Leu?Asp?Val?Lys

295 300 305

aac?gtt?gtg?tgg?aac?tcc?atc?tac?gag?gta?ggc?cac?cgc?gtc?gca?gac 1075

Asn?Val?Val?Trp?Asn?Ser?Ile?Tyr?Glu?Val?Gly?His?Arg?Val?Ala?Asp

310 315 320 325

cat?ttc?gat?gac?cgt?gtt?tca?gaa?aaa?acc?tcg?agc?gaa?cac?cca?cgc 1123

His?Phe?Asp?Asp?Arg?Val?Ser?Glu?Lys?Thr?Ser?Ser?Glu?His?Pro?Arg

330 335 340

att?ttc?att?gct?ggc?gac?gcc?tgc?cac?acc?cac?agc?gct?aag?gct?ggc 1171

Ile?Phe?Ile?Ala?Gly?Asp?Ala?Cys?His?Thr?His?Ser?Ala?Lys?Ala?Gly

345 350 355

cag?ggc?atg?aac?gtg?tcc?atg?cag?gac?gga?ttc?aac?ctt?ggc?tgg?aag 1219

Gln?Gly?Met?Asn?Val?Ser?Met?Gln?Asp?Gly?Phe?Asn?Leu?Gly?Trp?Lys

360 365 370

ctt?gga?cat?gtg?gcc?agc?gga?aat?agc?cca?cgc?gaa?cta?ctt?cag?acc 1267

Leu?Gly?His?Val?Ala?Ser?Gly?Asn?Ser?Pro?Arg?Glu?Leu?Leu?Gln?Thr

375 380 385

tac?gct?gaa?gag?cgc?gaa?gac?att?gcc?tac?aag?ctc?atc?gag?tac?gac 1315

Tyr?Ala?Glu?Glu?Arg?Glu?Asp?Ile?Ala?Tyr?Lys?Leu?Ile?Glu?Tyr?Asp

390 395 400 405

aag?aac?tgg?tca?aca?ctc?atg?gca?aag?cca?agc?agc?gaa?atg?ggc?agt 1363

Lys?Asn?Trp?Ser?Thr?Leu?Met?Ala?Lys?Pro?Ser?Ser?Glu?Met?Gly?Ser

410 415 420

gcc?caa?gac?ctt?gag?gat?ttc?tac?cgc?gcg?aac?tct?gag?ttc?aat?gcc 1411

Ala?Gln?Asp?Leu?Glu?Asp?Phe?Tyr?Arg?Ala?Asn?Ser?Glu?Phe?Asn?Ala

425 430 435

ggc?tac?atg?acc?cac?tat?cct?cct?tct?tcc?atc?aca?atg?gat?ggc?agc 1459

Gly?Tyr?Met?Thr?His?Tyr?Pro?Pro?Ser?Ser?Ile?Thr?Met?Asp?Gly?Ser

440 445 450

aac?caa?gat?ctg?gca?aag?ggc?tac?cca?att?ggc?cga?cgc?ttc?aag?tca 1507

Asn?Gln?Asp?Leu?Ala?Lys?Gly?Tyr?Pro?Ile?Gly?Arg?Arg?Phe?Lys?Ser

455 460 465

gcg?atg?gtt?ggt?cga?gtc?tgc?gac?ttc?acc?gaa?aca?cac?ctc?ggt?cac 1555

Ala?Met?Val?Gly?Arg?Val?Cys?Asp?Phe?Thr?Glu?Thr?His?Leu?Gly?His

470 475 480 485

caa?gca?aca?gcc?gac?gga?cgc?atg?cgc?gca?tac?gtc?ttc?gca?gga?tcc 1603

Gln?Ala?Thr?Ala?Asp?Gly?Arg?Met?Arg?Ala?Tyr?Val?Phe?Ala?Gly?Ser

490 495 500

gat?gca?ctt?aac?ggc?gag?ggt?tct?gag?cta?gac?cgc?tgg?gca?gaa?tgg 1651

Asp?Ala?Leu?Asn?Gly?Glu?Gly?Ser?Glu?Leu?Asp?Arg?Trp?Ala?Glu?Trp

505 510 515

gca?gag?gcg?aac?ctt?gac?ccc?acg?ctt?gtc?gac?gcc?aag?gtg?att?tac 1699

Ala?Glu?Ala?Asn?Leu?Asp?Pro?Thr?Leu?Val?Asp?Ala?Lys?Val?Ile?Tyr

520 525 530

caa?agc?cct?tat?acc?gag?ctc?gac?acc?cgc?cag?gtt?cca?tcc?gtg?ttc 1747

Gln?Ser?Pro?Tyr?Thr?Glu?Leu?Asp?Thr?Arg?Gln?Val?Pro?Ser?Val?Phe

535 540 545

aaa?cct?gca?gtc?ggg?atc?ttc?gaa?ctg?acc?aat?gtg?gaa?aac?tcc?ttc 1795

Lys?Pro?Ala?Val?Gly?Ile?Phe?Glu?Leu?Thr?Asn?Val?Glu?Asn?Ser?Phe

550 555 560 565

ggt?atc?acc?acg?gac?tcc?gac?atc?ttt?gat?agt?cgc?gag?atc?tcc?cgc 1843

Gly?Ile?Thr?Thr?Asp?Ser?Asp?Ile?Phe?Asp?Ser?Arg?Glu?Ile?Ser?Arg

570 575 580

gat?ggt?gtc?gtg?gtg?gta?gtc?cga?cca?gac?caa?tac?gtt?tcc?gga?atc 1891

Asp?Gly?Val?Val?Val?Val?Val?Arg?Pro?Asp?Gln?Tyr?Val?Ser?Gly?Ile

585 590 595

ttc?cca?ctc?act?gat?acc?caa?ggg?ctt?ggc?gaa?ttc?ctc?acc?gga?tac 1939

Phe?Pro?Leu?Thr?Asp?Thr?Gln?Gly?Leu?Gly?Glu?Phe?Leu?Thr?Gly?Tyr

600 605 610

ttc?ccc?aaa?atg?aaa?ggc?gca?cat?cag?cta?atc?aac?gcg?aac 1981

Phe?Pro?Lys?Met?Lys?Gly?Ala?His?Gln?Leu?Ile?Asn?Ala?Asn

615 620 625

taaggcacag?ctgttaaaac?agt 2004

<210>30

<211>627

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>30

Met?Gln?Phe?His?Tyr?Glu?Gly?Tyr?Ala?Thr?Gly?Asp?Pro?Met?Glu?Met

1 5 10 15

Arg?Ala?Glu?Gly?Ser?Gly?Ile?Asn?Arg?Pro?Asp?Asp?Leu?Pro?Glu?Val

20 25 30

Met?Asp?Val?Leu?Ile?Val?Gly?Ala?Gly?Pro?Ala?Gly?Thr?Ile?Ala?Ala

35 40 45

Ala?Gln?Leu?Ser?Arg?Phe?Pro?Asn?Val?Thr?Thr?Arg?Leu?Val?Glu?Arg

50 55 60

Ser?Asp?Arg?Arg?Leu?Glu?Leu?Ala?Asn?Ala?Asp?Gly?Val?His?Ser?Arg

65 70 75 80

Thr?Ile?Glu?Thr?Phe?Gln?Ala?Phe?Gly?Phe?Ala?His?Glu?Ile?Leu?Ala

85 90 95

Glu?Ala?His?Glu?Ile?Thr?Asp?Met?Ala?Phe?Trp?Lys?Pro?Asp?Pro?Gln

100 105 110

Asn?Pro?Arg?Glu?Ile?Ile?Arg?Asp?Asn?Ser?Thr?Arg?Glu?Leu?Pro?Gln

115 120 125

His?Ile?Ser?Glu?Phe?Pro?Met?Ala?Leu?Leu?Thr?Gln?Thr?Arg?Ile?Ile

130 135 140

Asp?His?Phe?Asn?Arg?Phe?Met?Lys?Asn?Ser?Pro?Thr?Arg?Met?Lys?Pro

145 150 155 160

Asp?Tyr?Gly?Tyr?Glu?Phe?Val?Asp?Phe?Glu?Val?Glu?Glu?Asp?Ala?Glu

165 170 175

Tyr?Pro?Val?Ile?Val?Thr?Leu?Arg?Arg?Thr?Ser?Gly?Glu?Gln?Thr?Gly

180 185 190

Glu?Leu?Val?Thr?Val?Arg?Thr?Lys?Tyr?Leu?Val?Gly?Ala?Asp?Gly?Ala

195 200 205

Arg?Ser?Gln?Val?Arg?Lys?Ser?Leu?Gly?Tyr?Arg?Leu?Gln?Gly?Lys?Gln

210 215 220

Ala?Asn?His?Ala?Trp?Gly?Val?Met?Asp?Ile?His?Ala?Asn?Thr?Glu?Phe

225 230 235 240

Pro?Asp?Val?Arg?Lys?Lys?Cys?Thr?Ile?Lys?Ser?Asp?Ser?Gly?Arg?Thr

245 250 255

Ile?Leu?Leu?Ile?Pro?Arg?Glu?Gly?Gly?Phe?Leu?Phe?Arg?Leu?Tyr?Val

260 265 270

Asp?Leu?Gly?Glu?Val?Pro?Asp?Asp?Gly?Ser?Lys?Ala?Val?Arg?Asp?Thr

275 280 285

Pro?Leu?Gln?Asp?Val?Ile?Asp?Thr?Ala?Asn?Gln?Ile?Met?Ala?Pro?Phe

290 295 300

Thr?Leu?Asp?Val?Lys?Asn?Val?Val?Trp?Asn?Ser?Ile?Tyr?Glu?Val?Gly

305 310 315 320

His?Arg?Val?Ala?Asp?His?Phe?Asp?Asp?Arg?Val?Ser?Glu?Lys?Thr?Ser

325 330 335

Ser?Glu?His?Pro?Arg?Ile?Phe?Ile?Ala?Gly?Asp?Ala?Cys?His?Thr?His

340 345 350

Ser?Ala?Lys?Ala?Gly?Gln?Gly?Met?Asn?Val?Ser?Met?Gln?Asp?Gly?Phe

355 360 365

Asn?Leu?Gly?Trp?Lys?Leu?Gly?His?Val?Ala?Ser?Gly?Asn?Ser?Pro?Arg

370 375 380

Glu?Leu?Leu?Gln?Thr?Tyr?Ala?Glu?Glu?Arg?Glu?Asp?Ile?Ala?Tyr?Lys

385 390 395 400

Leu?Ile?Glu?Tyr?Asp?Lys?Asn?Trp?Ser?Thr?Leu?Met?Ala?Lys?Pro?Ser

405 410 415

Ser?Glu?Met?Gly?Ser?Ala?Gln?Asp?Leu?Glu?Asp?Phe?Tyr?Arg?Ala?Asn

420 425 430

Ser?Glu?Phe?Asn?Ala?Gly?Tyr?Met?Thr?His?Tyr?Pro?Pro?Ser?Ser?Ile

435 440 445

Thr?Met?Asp?Gly?Ser?Asn?Gln?Asp?Leu?Ala?Lys?Gly?Tyr?Pro?Ile?Gly

450 455 460

Arg?Arg?Phe?Lys?Ser?Ala?Met?Val?Gly?Arg?Val?Cys?Asp?Phe?Thr?Glu

465 470 475 480

Thr?His?Leu?Gly?His?Gln?Ala?Thr?Ala?Asp?Gly?Arg?Met?Arg?Ala?Tyr

485 490 495

Val?Phe?Ala?Gly?Ser?Asp?Ala?Leu?Asn?Gly?Glu?Gly?Ser?Glu?Leu?Asp

500 505 510

Arg?Trp?Ala?Glu?Trp?Ala?Glu?Ala?Asn?Leu?Asp?Pro?Thr?Leu?Val?Asp

515 520 525

Ala?Lys?Val?Ile?Tyr?Gln?Ser?Pro?Tyr?Thr?Glu?Leu?Asp?Thr?Arg?Gln

530 535 540

Val?Pro?Ser?Val?Phe?Lys?Pro?Ala?Val?Gly?Ile?Phe?Glu?Leu?Thr?Asn

545 550 555 560

Val?Glu?Asn?Ser?Phe?Gly?Ile?Thr?Thr?Asp?Ser?Asp?Ile?Phe?Asp?Ser

565 570 575

Arg?Glu?Ile?Ser?Arg?Asp?Gly?Val?Val?Val?Val?Val?Arg?Pro?Asp?Gln

580 585 590

Tyr?Val?Ser?Gly?Ile?Phe?Pro?Leu?Thr?Asp?Thr?Gln?Gly?Leu?G1y?Glu

595 600 605

Phe?Leu?Thr?Gly?Tyr?Phe?Pro?Lys?Met?Lys?Gly?Ala?His?Gln?Leu?Ile

610 615 620

Asn?Ala?Asn

625

<210>31

<211>915

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(892)

<223>RXN00675

<400>31

gtggaagtac?tcacctcaag?gtggccggaa?ccgcatgcat?tgtgcggtgc?cggccacctt?60

tggttttaac?agtttaattt?gaagaaagag?acgtggaagc?atg?ggt?ttc?cgt?tcc 115

Met?Gly?Phe?Arg?Ser

1 5

aag?aag?aag?gtt?att?gcg?gca?aag?acc?gcc?gct?gag?ctg?gac?gcg?atg 163

Lys?Lys?Lys?Val?Ile?Ala?Ala?Lys?Thr?Ala?Ala?Glu?Leu?Asp?Ala?Met

10 15 20

cag?gcg?gcg?ggt?gag?atc?gtc?ggc?aag?gct?ttg?cag?gct?gtg?cgc?gct 211

Gln?Ala?Ala?Gly?Glu?Ile?Val?Gly?Lys?Ala?Leu?Gln?Ala?Val?Arg?Ala

25 30 35

gag?gct?aaa?gct?ggc?atg?agc?acg?tgg?gat?ctg?gat?cag?atc?gcg?gag 259

Glu?Ala?Lys?Ala?Gly?Met?Ser?Thr?Trp?Asp?Leu?Asp?Gln?Ile?Ala?Glu

40 45 50

cag?gtt?atc?cgc?gat?gct?ggc?gcc?gtt?cct?aca?ttc?ctg?ggt?tac?cag 307

Gln?Val?Ile?Arg?Asp?Ala?Gly?Ala?Val?Pro?Thr?Phe?Leu?Gly?Tyr?Gln

55 60 65

ggt?ttt?ccg?gca?tca?gtg?tgc?gct?tcg?gtc?aat?gag?gtg?att?gtt?cac 355

Gly?Phe?Pro?Ala?Ser?Val?Cys?Ala?Ser?Val?Asn?Glu?Val?Ile?Val?His

70 75 80 85

ggc?att?cca?tcc?aag?gag?acc?atc?ttg?gag?gaa?ggc?gat?ctg?gtg?tcc 403

Gly?Ile?Pro?Ser?Lys?Glu?Thr?Ile?Leu?Glu?Glu?Gly?Asp?Leu?Val?Ser

90 95 100

atc?gac?tgc?ggc?gca?acc?ttt?gat?ggt?tgg?gtc?ggc?gat?tcc?gcg?tgg 451

Ile?Asp?Cys?Gly?Ala?Thr?Phe?Asp?Gly?Trp?Val?Gly?Asp?Ser?Ala?Trp

105 110 115

agc?ttc?ggc?atc?ggc?gag?ctg?gac?gag?gac?gtc?cag?ggt?ctc?aac?ttg 499

Ser?Phe?Gly?Ile?Gly?Glu?Leu?Asp?Glu?Asp?Val?Gln?Gly?Leu?Asn?Leu

120 125 130

gct?acc?gag?tgg?gtc?ctc?atg?gaa?ggc?atg?aag?gcc?atg?gtt?cca?ggc 547

Ala?Thr?Glu?Trp?Val?Leu?Met?Glu?Gly?Met?Lys?Ala?Met?Val?Pro?Gly

135 140 145

aac?cgt?ttg?acc?gat?gtc?tcc?cac?gct?ctc?gag?gtc?gca?acc?cgc?aag 595

Asn?Arg?Leu?Thr?Asp?Val?Ser?His?Ala?Leu?Glu?Val?Ala?Thr?Arg?Lys

150 155 160 165

gct?gag?tcc?aag?ttc?ggc?gtc?gcg?ctc?ggc?atc?gtc?gat?ggc?tac?ggc 643

Ala?Glu?Ser?Lys?Phe?Gly?Val?Ala?Leu?Gly?Ile?Val?Asp?Gly?Tyr?Gly

170 175 180

gga?cac?ggc?att?ggc?cgc?cac?atg?cac?gag?gag?cca?tac?ttg?gct?aat 691

Gly?His?Gly?Ile?Gly?Arg?His?Met?His?Glu?Glu?Pro?Tyr?Leu?Ala?Asn

185 190 195

gag?ggc?aag?gcc?ggc?aag?ggc?cct?gtg?att?cag?gag?ggc?tcc?gtg?ctc 739

Glu?Gly?Lys?Ala?Gly?Lys?Gly?Pro?Val?Ile?Gln?Glu?Gly?Ser?Val?Leu

200 205 210

gcc?att?gag?cct?atg?ctc?acc?ctc?ggc?acc?gaa?gat?tcc?gca?gtg?ctg 787

Ala?Ile?Glu?Pro?Met?Leu?Thr?Leu?Gly?Thr?Glu?Asp?Ser?Ala?Val?Leu

215 220 225

gaa?gat?gat?tgg?act?gtc?gtg?act?ctc?gac?ggt?tca?tgg?gca?tca?cac 835

Glu?Asp?Asp?Trp?Thr?Val?Val?Thr?Leu?Asp?Gly?Ser?Trp?Ala?Ser?His

230 235 240 245

tgg?gag?cac?acc?gtt?gca?gcc?acc?aag?ggc?ggc?ccg?cgc?atc?ctc?acg 883

Trp?Glu?His?Thr?Val?Ala?Ala?Thr?Lys?Gly?Gly?Pro?Arg?Ile?Leu?Thr

250 255 260

ccg?cgt?tat?taaaatgatg?cttttcgacg?cat 915

Pro?Arg?Tyr

<210>32

<211>264

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>32

Met?Gly?Phe?Arg?Ser?Lys?Lys?Lys?Val?Ile?Ala?Ala?Lys?Thr?Ala?Ala

1 5 10 15

Glu?Leu?Asp?Ala?Met?Gln?Ala?Ala?Gly?Glu?Ile?Val?Gly?Lys?Ala?Leu

20 25 30

Gln?Ala?Val?Arg?Ala?Glu?Ala?Lys?Ala?Gly?Met?Ser?Thr?Trp?Asp?Leu

35 40 45

Asp?Gln?Ile?Ala?Glu?Gln?Val?Ile?Arg?Asp?Ala?Gly?Ala?Val?Pro?Thr

50 55 60

Phe?Leu?Gly?Tyr?Gln?Gly?Phe?Pro?Ala?Ser?Val?Cys?Ala?Ser?Val?Asn

65 70 75 80

Glu?Val?Ile?Val?His?Gly?Ile?Pro?Ser?Lys?Glu?Thr?Ile?Leu?Glu?Glu

85 90 95

Gly?Asp?Leu?Val?Ser?Ile?Asp?Cys?Gly?Ala?Thr?Phe?Asp?Gly?Trp?Val

100 105 110

Gly?Asp?Ser?Ala?Trp?Ser?Phe?Gly?Ile?Gly?Glu?Leu?Asp?Glu?Asp?Val

115 120 125

Gln?Gly?Leu?Asn?Leu?Ala?Thr?Glu?Trp?Val?Leu?Met?Glu?Gly?Met?Lys

130 135 140

Ala?Met?Val?Pro?Gly?Asn?Arg?Leu?Thr?Asp?Val?Ser?His?Ala?Leu?Glu

145 150 155 160

Val?Ala?Thr?Arg?Lys?Ala?Glu?Ser?Lys?Phe?Gly?Val?Ala?Leu?Gly?Ile

165 170 175

Val?Asp?Gly?Tyr?Gly?Gly?His?Gly?Ile?Gly?Arg?His?Met?His?Glu?Glu

180 185 190

Pro?Tyr?Leu?Ala?Asn?Glu?Gly?Lys?Ala?Gly?Lys?Gly?Pro?Val?Ile?Gln

195 200 205

Glu?Gly?Ser?Val?Leu?Ala?Ile?Glu?Pro?Met?Leu?Thr?Leu?Gly?Thr?Glu

210 215 220

Asp?Ser?Ala?Val?Leu?Glu?Asp?Asp?Trp?Thr?Val?Val?Thr?Leu?Asp?Gly

225 230 235 240

Ser?Trp?Ala?Ser?His?Trp?Glu?His?Thr?Val?Ala?Ala?Thr?Lys?Gly?Gly

245 250 255

Pro?Arg?Ile?Leu?Thr?Pro?Arg?Tyr

260

<210>33

<211>506

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(483)

<223>FRXA00675

<400>33

tgc?ggc?gca?acc?ttt?gat?ggt?tgg?gtc?ggc?gat?tcc?gcg?tgg?agc?ttc 48

Cys?Gly?Ala?Thr?Phe?Asp?Gly?Trp?Val?Gly?Asp?Ser?Ala?Trp?Ser?Phe

1 5 10 15

ggc?atc?ggc?gag?ctg?gac?gag?gac?gtc?cag?ggt?ctc?aac?ttg?gct?acc 96

Gly?Ile?Gly?Glu?Leu?Asp?Glu?Asp?Val?Gln?Gly?Leu?Asn?Leu?Ala?Thr

20 25 30

gag?tgg?gtc?ctc?atg?gaa?ggc?atg?aag?gcc?atg?gtt?cca?ggc?aac?cgt 144

Glu?Trp?Val?Leu?Met?Glu?Gly?Met?Lys?Ala?Met?Val?Pro?Gly?Asn?Arg

35 40 45

ttg?acc?gat?gtc?tcc?cac?gct?ctc?gag?gtc?gca?acc?cgc?aag?gct?gag 192

Leu?Thr?Asp?Val?Ser?His?Ala?Leu?Glu?Val?Ala?Thr?Arg?Lys?Ala?Glu

50 55 60

tcc?aag?ttc?ggc?gtc?gcg?ctc?ggc?atc?gtc?gat?ggc?tac?ggc?gga?cac 240

Ser?Lys?Phe?Gly?Val?Ala?Leu?Gly?Ile?Val?Asp?Gly?Tyr?Gly?Gly?His

65 70 75 80

ggc?att?ggc?cgc?cac?atg?cac?gag?gag?cca?tac?ttg?gct?aat?gag?ggc 288

Gly?Ile?Gly?Arg?His?Met?His?Glu?Glu?Pro?Tyr?Leu?Ala?Asn?Glu?Gly

85 90 95

aag?gcc?ggc?aag?ggc?cct?gtg?att?cag?gag?ggc?tcc?gtg?ctc?gcc?att 336

Lys?Ala?Gly?Lys?Gly?Pro?Val?Ile?Gln?Glu?Gly?Ser?Val?Leu?Ala?Ile

100 105 110

gag?cct?atg?ctc?acc?ctc?ggc?acc?gaa?gat?tcc?gca?gtg?ctg?gaa?gat 384

Glu?Pro?Met?Leu?Thr?Leu?Gly?Thr?Glu?Asp?Ser?Ala?Val?Leu?Glu?Asp

115 120 125

gat?tgg?act?gtc?gtg?act?ctc?gac?ggt?tca?tgg?gca?tca?cac?tgg?gag 432

Asp?Trp?Thr?Val?Val?Thr?Leu?Asp?Gly?Ser?Trp?Ala?Ser?His?Trp?Glu

130 135 140

cac?acc?gtt?gca?gcc?acc?aag?ggc?ggc?ccg?cgc?atc?ctc?acg?ccg?cgt 480

His?Thr?Val?Ala?Ala?Thr?Lys?Gly?Gly?Pro?Arg?Ile?Leu?Thr?Pro?Arg

145 150 155 160

tat?taaaatgatg?cttttcgacg?cat 506

Tyr

<210>34

<211>161

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>34

Cys?Gly?Ala?Thr?Phe?Asp?Gly?Trp?Val?Gly?Asp?Ser?Ala?Trp?Ser?Phe

1 5 10 15

Gly?Ile?Gly?Glu?Leu?Asp?Glu?Asp?Val?Gln?Gly?Leu?Asn?Leu?Ala?Thr

20 25 30

Glu?Trp?Val?Leu?Met?Glu?Gly?Met?Lys?Ala?Met?Val?Pro?Gly?Asn?Arg

35 40 45

Leu?Thr?Asp?Val?Ser?His?Ala?Leu?Glu?Val?Ala?Thr?Arg?Lys?Ala?Glu

50 55 60

Ser?Lys?Phe?Gly?Val?Ala?Leu?Gly?Ile?Val?Asp?Gly?Tyr?Gly?Gly?His

65 70 75 80

Gly?Ile?Gly?Arg?His?Met?His?Glu?Glu?Pro?Tyr?Leu?Ala?Asn?Glu?Gly

85 90 95

Lys?Ala?Gly?Lys?Gly?Pro?Val?Ile?Gln?Glu?Gly?Ser?Val?Leu?Ala?Ile

100 105 110

Glu?Pro?Met?Leu?Thr?Leu?Gly?Thr?Glu?Asp?Ser?Ala?Val?Leu?Glu?Asp

115 120 125

Asp?Trp?Thr?Val?Val?Thr?Leu?Asp?Gly?Ser?Trp?Ala?Ser?His?Trp?Glu

130 135 140

His?Thr?Val?Ala?Ala?Thr?Lys?Gly?Gly?Pro?Arg?Ile?Leu?Thr?Pro?Arg

145 150 155 160

Tyr

<210>35

<211>996

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(973)

<223>RXA01609

<400>35

gttgcagtca?gtgaagctga?agagcagcca?gtcggctaaa?aaatagcctc?catccaaccc?60

gctttacctg?tcatcgcttc?aggcgactag?catggtgacc?atg?tct?aaa?atg?cgc 115

Met?Ser?Lys?Met?Arg

1 5

gca?cca?ctt?gta?ccc?gga?att?cct?acc?cca?atc?agg?gaa?gta?cct?gca 163

Ala?Pro?Leu?Val?Pro?Gly?Ile?Pro?Thr?Pro?Ile?Arg?Glu?Val?Pro?Ala

10 15 20

cat?att?gaa?cgt?cca?gaa?tat?gtg?tgg?aag?gac?gaa?gtc?caa?gaa?gca 211

His?Ile?Glu?Arg?Pro?Glu?Tyr?Val?Trp?Lys?Asp?Glu?Val?Gln?Glu?Ala

25 30 35

atc?ggt?gag?cct?ttt?gtg?cag?gcc?cct?gag?gtc?atc?gag?aag?atg?cgt 259

Ile?Gly?Glu?Pro?Phe?Val?Gln?Ala?Pro?Glu?Val?Ile?Glu?Lys?Met?Arg

40 45 50

gag?aca?tct?cgc?atc?gct?gca?aac?tca?ctg?aaa?atc?gcg?ggc?gaa?gcc 307

Glu?Thr?Ser?Arg?Ile?Ala?Ala?Asn?Ser?Leu?Lys?Ile?Ala?Gly?Glu?Ala

55 60 65

gtc?aag?cca?ggc?gtg?acc?act?gat?gaa?ctt?gat?cgc?att?gtg?cat?gag 355

Val?Lys?Pro?Gly?Val?Thr?Thr?Asp?Glu?Leu?Asp?Arg?Ile?Val?His?Glu

70 75 80 85

tac?acc?tgc?gat?atg?ggc?gca?tac?cct?tca?gat?ctt?ggt?tac?cgg?gga 403

Tyr?Thr?Cys?Asp?Met?Gly?Ala?Tyr?Pro?Ser?Asp?Leu?Gly?Tyr?Arg?Gly

90 95 100

ttc?acc?aag?tcc?tca?tgc?att?tcc?ctc?aat?gag?atc?gtg?tgc?cac?ggt 451

Phe?Thr?Lys?Ser?Ser?Cys?Ile?Ser?Leu?Asn?Glu?Ile?Val?Cys?His?Gly

105 110 115

att?cct?gat?tcc?acc?gtc?att?gaa?gag?ggc?gat?att?gtt?aac?atc?gat 499

Ile?Pro?Asp?Ser?Thr?Val?Ile?Glu?Glu?Gly?Asp?Ile?Val?Asn?Ile?Asp

120 125 130

gtc?acc?gcg?ttc?aag?cac?ggc?gtc?cac?ggc?gac?tgc?aat?gcc?acc?ttc 547

Val?Thr?Ala?Phe?Lys?His?Gly?Val?His?Gly?Asp?Cys?Asn?Ala?Thr?Phe

135 140 145

tta?gcg?ggt?gat?gtt?tct?gaa?gaa?cac?cgc?ctg?ctg?gtt?gag?cgc?acc 595

Leu?Ala?Gly?Asp?Val?Ser?Glu?Glu?His?Arg?Leu?Leu?Val?Glu?Arg?Thr

150 155 160 165

gaa?gaa?gcc?atg?atg?cgt?tcc?atc?cgt?gca?gca?aag?cct?gga?cgt?gaa 643

Glu?Glu?Ala?Met?Met?Arg?Ser?Ile?Arg?Ala?Ala?Lys?Pro?Gly?Arg?Glu

170 175 180

atc?aac?gtc?att?ggg?cgt?gtc?att?gag?tct?tac?gcc?aag?cgt?ttt?ggc 691

Ile?Asn?Val?Ile?Gly?Arg?Val?Ile?Glu?Ser?Tyr?Ala?Lys?Arg?Phe?Gly

185 190 195

tac?aac?gtg?gtc?cgc?gat?ttc?acc?gga?cac?ggc?atc?ggc?cca?act?ttc 739

Tyr?Asn?Val?Val?Arg?Asp?Phe?Thr?Gly?His?Gly?Ile?Gly?Pro?Thr?Phe

200 205 210

cac?aac?ggc?ctt?gtg?gtg?ctg?cac?tac?gac?aac?act?cag?tac?cgc?gat 787

His?Asn?Gly?Leu?Val?Val?Leu?His?Tyr?Asp?Asn?Thr?Gln?Tyr?Arg?Asp

215 220 225

ctg?ctc?gtg?cca?ggc?atg?acc?ttg?acc?atc?gag?cca?atg?atc?aac?ctt 835

Leu?Leu?Val?Pro?Gly?Met?Thr?Leu?Thr?Ile?Glu?Pro?Met?Ile?Asn?Leu

230 235 240 245

ggt?tcc?ctc?gac?tac?gag?atc?tgg?gaa?gat?gat?tgg?act?gtc?caa?aac 883

Gly?Ser?Leu?Asp?Tyr?Glu?Ile?Trp?Glu?Asp?Asp?Trp?Thr?Val?Gln?Asn

250 255 260

gtt?gac?cgt?aag?ttc?agc?gcg?cag?ttc?gag?cac?acc?att?gtc?atc?acc 931

Val?Asp?Arg?Lys?Phe?Ser?Ala?Gln?Phe?Glu?His?Thr?Ile?Val?Ile?Thr

265 270 275

gaa?gac?ggc?aat?gag?atc?ctc?acc?ctc?cca?gac?gat?tcc?gtc 973

Glu?Asp?Gly?Asn?Glu?Ile?Leu?Thr?Leu?Pro?Asp?Asp?Ser?Val

280 285 290

taaaaacgcc?taggccacaa?gcc 996

<210>36

<211>291

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>36

Met?Ser?Lys?Met?Arg?Ala?Pro?Leu?Val?Pro?Gly?Ile?Pro?Thr?Pro?Ile

1 5 10 15

Arg?Glu?Val?Pro?Ala?His?Ile?Glu?Arg?Pro?Glu?Tyr?Val?Trp?Lys?Asp

20 25 30

Glu?Val?Gln?Glu?Ala?Ile?Gly?Glu?Pro?Phe?Val?Gln?Ala?Pro?Glu?Val

35 40 45

Ile?Glu?Lys?Met?Arg?Glu?Thr?Ser?Arg?Ile?Ala?Ala?Asn?Ser?Leu?Lys

50 55 60

Ile?Ala?Gly?Glu?Ala?Val?Lys?Pro?Gly?Val?Thr?Thr?Asp?Glu?Leu?Asp

65 70 75 80

Arg?Ile?Val?His?Glu?Tyr?Thr?Cys?Asp?Met?Gly?Ala?Tyr?Pro?Ser?Asp

85 90 95

Leu?Gly?Tyr?Arg?Gly?Phe?Thr?Lys?Ser?Ser?Cys?Ile?Ser?Leu?Asn?Glu

100 105 110

Ile?Val?Cys?His?Gly?Ile?Pro?Asp?Ser?Thr?Val?Ile?Glu?Glu?Gly?Asp

115 120 125

Ile?Val?Asn?Ile?Asp?Val?Thr?Ala?Phe?Lys?His?Gly?Val?His?Gly?Asp

130 135 140

Cys?Asn?Ala?Thr?Phe?Leu?Ala?Gly?Asp?Val?Ser?Glu?Glu?His?Arg?Leu

145 150 155 160

Leu?Val?Glu?Arg?Thr?Glu?Glu?Ala?Met?Met?Arg?Ser?Ile?Arg?Ala?Ala

165 170 175

Lys?Pro?Gly?Arg?Glu?Ile?Asn?Val?Ile?Gly?Arg?Val?Ile?Glu?Ser?Tyr

180 185 190

Ala?Lys?Arg?Phe?Gly?Tyr?Asn?Val?Val?Arg?Asp?Phe?Thr?Gly?His?Gly

195 200 205

Ile?Gly?Pro?Thr?Phe?His?Asn?Gly?Leu?Val?Val?Leu?His?Tyr?Asp?Asn

210 215 220

Thr?Gln?Tyr?Arg?Asp?Leu?Leu?Val?Pro?Gly?Met?Thr?Leu?Thr?Ile?Glu

225 230 235 240

Pro?Met?Ile?Asn?Leu?Gly?Ser?Leu?Asp?Tyr?Glu?Ile?Trp?GIu?Asp?Asp

245 250 255

Trp?Thr?Val?Gln?Asn?Val?Asp?Arg?Lys?Phe?Ser?Ala?Gln?Phe?Glu?His

260 265 270

Thr?Ile?Val?Ile?Thr?Glu?Asp?Gly?Asn?Glu?Ile?Leu?Thr?Leu?Pro?Asp

275 280 285

Asp?Ser?Val

290

<210>37

<211>1644

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1621)

<223>RXA01358

<400>37

gagggtaaac?cttatactcc?gattcgtttt?gatgtggtgg?caatcgtttt?ggatccgcac?60

acggggcgcc?cagagatcac?tgtttatgag?gatgtggaac?atg?gcg?ctc?ggt?aga 115

Met?Ala?Leu?Gly?Arg

1 5

act?ata?tcc?act?gcg?caa?tta?ggt?gtg?cag?gca?aaa?atc?gtt?cgt?gtg 163

Thr?Ile?Ser?Thr?Ala?Gln?Leu?Gly?Val?Gln?Ala?Lys?Ile?Val?Arg?Val

10 15 20

gag?gct?aat?gtt?ggc?cca?gga?ttg?cct?ggt?acc?tac?att?gtt?gga?tta 211

Glu?Ala?Asn?Val?Gly?Pro?Gly?Leu?Pro?Gly?Thr?Tyr?Ile?Val?Gly?Leu

25 30 35

gca?gat?act?gcc?att?tca?gaa?tct?cgg?gat?cgt?att?aaa?act?gcg?gtg 259

Ala?Asp?Thr?Ala?Ile?Ser?Glu?Ser?Arg?Asp?Arg?Ile?Lys?Thr?Ala?Val

40 45 50

caa?aac?agt?ggc?ttg?atg?tgg?cca?aag?acc?aaa?gtg?atc?att?aac?ctc 307

Gln?Asn?Ser?Gly?Leu?Met?Trp?Pro?Lys?Thr?Lys?Val?Ile?Ile?Asn?Leu

55 60 65

tcg?ccg?gct?tcc?atg?cgt?aaa?caa?ggt?tcg?cag?tgt?gat?ctc?gcg?atg 355

Ser?Pro?Ala?Ser?Met?Arg?Lys?Gln?Gly?Ser?Gln?Cys?Asp?Leu?Ala?Met

70 75 80 85

acc?gtt?gca?gtt?ctc?gtt?gcc?cat?ggc?tct?aac?ccc?aaa?gcg?aag?ttt 403

Thr?Val?Ala?Val?Leu?Val?Ala?His?Gly?Ser?Asn?Pro?Lys?Ala?Lys?Phe

90 95 100

cat?gcg?cag?aac?acg?tta?ttt?ctg?ggt?gag?gtg?gcg?ctt?gat?gga?acc 451

His?Ala?Gln?Asn?Thr?Leu?Phe?Leu?Gly?Glu?Val?Ala?Leu?Asp?Gly?Thr

105 110 115

ttg?ctc?cct?gtt?act?gga?gtt?ctt?cca?gcg?ctg?ttg?gcc?gcg?aag?gag 499

Leu?Leu?Pro?Val?Thr?Gly?Val?Leu?Pro?Ala?Leu?Leu?Ala?Ala?Lys?Glu

120 125 130

gaa?ggt?att?ggc?aag?att?gtg?atc?ccg?gag?gga?aat?gcc?caa?gaa?gca 547

Glu?Gly?Ile?Gly?Lys?Ile?Val?Ile?Pro?Glu?Gly?Asn?Ala?Gln?Glu?Ala

135 140 145

gga?ctg?gtt?gag?gat?cct?tca?gtc?ttt?ttg?gca?cat?tcc?atc?gac?cag 595

Gly?Leu?Val?Glu?Asp?Pro?Ser?Val?Phe?Leu?Ala?His?Ser?Ile?Asp?Gln

150 155 160 165

gtc?ttg?cga?tgg?ctt?gat?ggg?gaa?gag?gcg?ttg?cct?cag?cct?gga?cta 643

Val?Leu?Arg?Trp?Leu?Asp?Gly?Glu?Glu?Ala?Leu?Pro?Gln?Pro?Gly?Leu

170 175 180

ttc?aat?gat?gaa?aat?agc?ctc?aaa?ctg?cct?gat?atg?cgt?gat?gtg?gtg 691

Phe?Asn?Asp?Glu?Asn?Ser?Leu?Lys?Leu?Pro?Asp?Met?Arg?Asp?Val?Val

185 190 195

gga?caa?cca?gaa?gct?agg?ttt?gct?gca?gaa?gta?gct?gct?gcc?ggt?ggt 739

Gly?Gln?Pro?Glu?Ala?Arg?Phe?Ala?Ala?Glu?Val?Ala?Ala?Ala?Gly?Gly

200 205 210

cac?cac?atg?ctg?atg?att?ggc?cct?ccc?ggt?tct?gga?aaa?tcc?atg?atc 787

His?His?Met?Leu?Met?Ile?Gly?Pro?Pro?Gly?Ser?Gly?Lys?Ser?Met?Ile

215 220 225

gcc?gag?cgg?att?ccc?agc?ttg?ctt?ccc?gaa?ctg?tcg?ccc?caa?caa?atg 835

Ala?Glu?Arg?Ile?Pro?Ser?Leu?Leu?Pro?Glu?Leu?Ser?Pro?Gln?Gln?Met

230 235 240 245

atc?gag?gcg?acg?gca?gtg?cat?tcc?gtt?gtg?ggg?cga?acc?ttt?tca?ggg 883

Ile?Glu?Ala?Thr?Ala?Val?His?Ser?Val?Val?Gly?Arg?Thr?Phe?Ser?Gly

250 255 260

ccg?gtg?tcg?agg?gct?ccg?ttt?att?tcc?cca?cac?cac?aat?gtc?agc?aag 931

Pro?Val?Ser?Arg?Ala?Pro?Phe?Ile?Ser?Pro?His?His?Asn?Val?Ser?Lys

265 270 275

gct?gct?ctg?ctc?gga?ggt?ggc?tcg?gga?tct?cct?ctt?ccg?ggt?gct?atc 979

Ala?Ala?Leu?Leu?Gly?Gly?Gly?Ser?Gly?Ser?Pro?Leu?Pro?Gly?Ala?Ile

280 285 290

agc?ctg?gcg?cat?cat?ggt?gtg?ttg?ttc?ctg?gat?gag?gtt?agt?gag?att 1027

Ser?Leu?Ala?His?His?Gly?Val?Leu?Phe?Leu?Asp?Glu?Val?Ser?Glu?Ile

295 300 305

cca?gcg?tca?atc?ctt?gat?tct?ttg?agg?act?cca?ttg?gaa?tac?ggc?tcg 1075

Pro?Ala?Ser?Ile?Leu?Asp?Ser?Leu?Arg?Thr?Pro?Leu?Glu?Tyr?Gly?Ser

310 315 320 325

atc?cgc?atc?atc?aga?tcc?cgc?cat?gat?gtc?acc?ttc?ccc?gca?cag?ttc 1123

Ile?Arg?Ile?Ile?Arg?Ser?Arg?His?Asp?Val?Thr?Phe?Pro?Ala?Gln?Phe

330 335 340

cag?ctc?atc?ctc?gcg?gcc?aat?ccg?tgt?aga?tgc?ggt?gca?gaa?cag?cct 1171

Gln?Leu?Ile?Leu?Ala?Ala?Asn?Pro?Cys?Arg?Cys?Gly?Ala?Glu?Gln?Pro

345 350 355

caa?gaa?tgt?gtc?tgt?tct?ggc?tca?gct?cgc?gcg?acg?tac?ctt?aat?aat 1219

Gln?Glu?Cys?Val?Cys?Ser?Gly?Ser?Ala?Arg?Ala?Thr?Tyr?Leu?Asn?Asn

360 365 370

ctt?tcg?ggt?ccg?ttg?agg?gat?cgc?ttg?gac?atg?gtt?gtt?gcc?acc?cac 1267

Leu?Ser?Gly?Pro?Leu?Arg?Asp?Arg?Leu?Asp?Met?Val?Val?Ala?Thr?His

375 380 385

tct?aaa?ggt?gca?gtg?ctg?cgt?agt?gat?gac?gtt?gag?gca?tct?gct?ccc 1315

Ser?Lys?Gly?Ala?Val?Leu?Arg?Ser?Asp?Asp?Val?Glu?Ala?Ser?Ala?Pro

390 395 400 405

att?gct?gat?cgg?gtg?gca?caa?gct?cgt?gag?agg?gca?gct?ttc?cga?tgg 1363

Ile?Ala?Asp?Arg?Val?Ala?Gln?Ala?Arg?Glu?Arg?Ala?Ala?Phe?Arg?Trp

410 415 420

cgc?cgt?tct?gga?ctg?gga?aat?ctt?gtt?aat?gca?cac?gta?gat?cca?cac 1411

Arg?Arg?Ser?Gly?Leu?Gly?Asn?Leu?Val?Asn?Ala?His?Val?Asp?Pro?His

425 430 435

ttc?ttg?cgg?agg?aat?ttt?gcc?gca?aca?gaa?gac?gcc?atg?gtg?tac?ctc 1459

Phe?Leu?Arg?Arg?Asn?Phe?Ala?Ala?Thr?Glu?Asp?Ala?Met?Val?Tyr?Leu

440 445 450

ggc?gcg?ttc?ctg?gcg?gaa?gga?aca?atc?tcc?caa?cgt?ggc?tgc?gat?cgg 1507

Gly?Ala?Phe?Leu?Ala?Glu?Gly?Thr?Ile?Ser?Gln?Arg?Gly?Cys?Asp?Arg

455 460 465

gcc?ata?aaa?ctg?ggt?tgg?acc?ttg?tgc?gat?ttg?gat?ggg?gaa?cag?cag 1555

Ala?Ile?Lys?Leu?Gly?Trp?Thr?Leu?Cys?Asp?Leu?Asp?Gly?Glu?Gln?Gln

470 475 480 485

ccc?aat?ctt?gac?cat?att?gcg?cga?gcc?atg?gag?ctt?cgg?ggc?act?aca 1603

Pro?Asn?Leu?Asp?His?Ile?Ala?Arg?Ala?Met?Glu?Leu?Arg?Gly?Thr?Thr

490 495 500

tac?agt?gag?gta?gca?gca?tgattgactc?ccgcttgctg?gca 1644

Tyr?Ser?Glu?Val?Ala?Ala

505

<210>38

<211>507

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>38

Met?Ala?Leu?Gly?Arg?Thr?Ile?Ser?Thr?Ala?Gln?Leu?Gly?Val?Gln?Ala

1 5 10 15

Lys?Ile?Val?Arg?Val?Glu?Ala?Asn?Val?Gly?Pro?Gly?Leu?Pro?Gly?Thr

20 25 30

Tyr?Ile?Val?Gly?Leu?Ala?Asp?Thr?Ala?Ile?Ser?Glu?Ser?Arg?Asp?Arg

35 40 45

Ile?Lys?Thr?Ala?Val?Gln?Asn?Ser?Gly?Leu?Met?Trp?Pro?Lys?Thr?Lys

50 55 60

Val?Ile?Ile?Asn?Leu?Ser?Pro?Ala?Ser?Met?Arg?Lys?Gln?Gly?Ser?Gln

65 70 75 80

Cys?Asp?Leu?Ala?Met?Thr?Val?Ala?Val?Leu?Val?Ala?His?Gly?Ser?Asn

85 90 95

Pro?Lys?Ala?Lys?Phe?His?Ala?Gln?Asn?Thr?Leu?Phe?Leu?Gly?Glu?Val

100 105 110

Ala?Leu?Asp?Gly?Thr?Leu?Leu?Pro?Val?Thr?Gly?Val?Leu?Pro?Ala?Leu

115 120 125

Leu?Ala?Ala?Lys?Glu?Glu?Gly?Ile?Gly?Lys?Ile?Val?Ile?Pro?Glu?Gly

130 135 140

Asn?Ala?Gln?Glu?Ala?Gly?Leu?Val?Glu?Asp?Pro?Ser?Val?Phe?Leu?Ala

145 150 155 160

His?Ser?Ile?Asp?Gln?Val?Leu?Arg?Trp?Leu?Asp?Gly?Glu?Glu?Ala?Leu

165 170 175

Pro?Gln?Pro?Gly?Leu?Phe?Asn?Asp?Glu?Asn?Ser?Leu?Lys?Leu?Pro?Asp

180 185 190

Met?Arg?Asp?Val?Val?Gly?Gln?Pro?Glu?Ala?Arg?Phe?Ala?Ala?Glu?Val

195 200 205

Ala?Ala?Ala?Gly?Gly?His?His?Met?Leu?Met?Ile?Gly?Pro?Pro?Gly?Ser

210 215 220

Gly?Lys?Ser?Met?Ile?Ala?Glu?Arg?Ile?Pro?Ser?Leu?Leu?Pro?Glu?Leu

225 230 235 240

Ser?Pro?Gln?Gln?Met?Ile?Glu?Ala?Thr?Ala?Val?His?Ser?Val?Val?Gly

245 250 255

Arg?Thr?Phe?Ser?Gly?Pro?Val?Ser?Arg?Ala?Pro?Phe?Ile?Ser?Pro?His

260 265 270

His?Asn?Val?Ser?Lys?Ala?Ala?Leu?Leu?Gly?Gly?Gly?Ser?Gly?Ser?Pro

275 280 285

Leu?Pro?Gly?Ala?Ile?Ser?Leu?Ala?His?His?Gly?Val?Leu?Phe?Leu?Asp

290 295 300

Glu?Val?Ser?Glu?Ile?Pro?Ala?Ser?Ile?Leu?Asp?Ser?Leu?Arg?Thr?Pro

305 310 315 320

Leu?Glu?Tyr?Gly?Ser?Ile?Arg?Ile?Ile?Arg?Ser?Arg?His?Asp?Val?Thr

325 330 335

Phe?Pro?Ala?Gln?Phe?Gln?Leu?Ile?Leu?Ala?Ala?Asn?Pro?Cys?Arg?Cys

340 345 350

Gly?Ala?Glu?Gln?Pro?Gln?Glu?Cys?Val?Cys?Ser?Gly?Ser?Ala?Arg?Ala

355 360 365

Thr?Tyr?Leu?Asn?Asn?Leu?Ser?Gly?Pro?Leu?Arg?Asp?Arg?Leu?Asp?Met

370 375 380

Val?Val?Ala?Thr?His?Ser?Lys?Gly?Ala?Val?Leu?Arg?Ser?Asp?Asp?Val

385 390 395 400

Glu?Ala?Ser?Ala?Pro?Ile?Ala?Asp?Arg?Val?Ala?Gln?Ala?Arg?Glu?Arg

405 410 415

Ala?Ala?Phe?Arg?Trp?Arg?Arg?Ser?Gly?Leu?Gly?Asn?Leu?Val?Asn?Ala

420 425 430

His?Val?Asp?Pro?His?Phe?Leu?Arg?Arg?Asn?Phe?Ala?Ala?Thr?Glu?Asp

435 440 445

Ala?Met?Val?Tyr?Leu?Gly?Ala?Phe?Leu?Ala?Glu?Gly?Thr?Ile?Ser?Gln

450 455 460

Arg?Gly?Cys?Asp?Arg?Ala?Ile?Lys?Leu?Gly?Trp?Thr?Leu?Cys?Asp?Leu

465 470 475 480

Asp?Gly?Glu?Gln?Gln?Pro?Asn?Leu?Asp?His?Ile?Ala?Arg?Ala?Met?Glu

485 490 495

Leu?Arg?Gly?Thr?Thr?Tyr?Ser?Glu?Val?Ala?Ala

500 505

<210>39

<211>1173

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1150)

<223>RXA01458

<400>39

gccattagag?ttcatattta?ccaatctaca?aggcaactat?ttcctattgc?tacgatccga?60

acaacgctgt?aagcgaacac?aggttgtagg?gtggatattc?gtg?aat?cgc?cga?atc 115

Val?Asn?Arg?Arg?Ile

1 5

aag?act?ctg?acg?tgg?ggt?gct?atc?cct?ttg?gtg?ctg?ctg?gca?tcg?ttg 163

Lys?Thr?Leu?Thr?Trp?Gly?Ala?Ile?Pro?Leu?Val?Leu?Leu?Ala?Ser?Leu

10 15 20

gta?agc?att?gac?cat?att?ccg?gga?aca?aac?atc?aac?ttg?agc?gtg?cct 211

Val?Ser?Ile?Asp?His?Ile?Pro?Gly?Thr?Asn?Ile?Asn?Leu?Ser?Val?Pro

25 30 35

tat?gcc?gct?gaa?ggc?cca?ggt?cct?acg?atc?aat?acg?ctt?ggt?cag?gtc 259

Tyr?Ala?Ala?Glu?Gly?Pro?Gly?Pro?Thr?Ile?Asn?Thr?Leu?Gly?Gln?Val

40 45 50

gac?ggc?gag?gat?gtt?gtg?tcc?atc?agt?agt?gct?gat?ctg?gat?gag?acc 307

Asp?Gly?Glu?Asp?Val?Val?Ser?Ile?Ser?Ser?Ala?Asp?Leu?Asp?Glu?Thr

55 60 65

gaa?ggt?aac?ctg?aac?atg?acc?act?gtg?tcg?gtt?cgt?tcc?ggc?atg?aca 355

Glu?Gly?Asn?Leu?Asn?Met?Thr?Thr?Val?Ser?Val?Arg?Ser?Gly?Met?Thr

70 75 80 85

ttg?tcg?cag?gta?att?tcc?cga?tgg?ctg?ttt?acc?gat?gac?aca?atc?gtt 403

Leu?Ser?Gln?Val?Ile?Ser?Arg?Trp?Leu?Phe?Thr?Asp?Asp?Thr?Ile?Val

90 95 100

ccc?atc?gag?cag?gtt?ttc?cct?ccc?ggc?caa?tcc?acc?gag?gaa?gtc?gaa 451

Pro?Ile?Glu?Gln?Val?Phe?Pro?Pro?Gly?Gln?Ser?Thr?Glu?Glu?Val?Glu

105 110 115

gaa?tcc?aac?cgc?acc?gcg?ttc?atc?tct?tcg?gag?tct?tcc?gca?acg?atc 499

Glu?Ser?Asn?Arg?Thr?Ala?Phe?Ile?Ser?Ser?Glu?Ser?Ser?Ala?Thr?Ile

120 125 130

gcc?gcg?atg?aat?tac?ctc?aac?att?ccc?gtc?gaa?gtt?gaa?gtt?gca?gaa 547

Ala?Ala?Met?Asn?Tyr?Leu?Asn?Ile?Pro?Val?Glu?Val?Glu?Val?Ala?Glu

135 140 145

gtc?ctc?acc?gac?agc?gcc?gca?acc?gga?att?ttc?gaa?ccc?ggc?gac?aaa 595

Val?Leu?Thr?Asp?Ser?Ala?Ala?Thr?Gly?Ile?Phe?Glu?Pro?Gly?Asp?Lys

150 155 160 165

ctt?ctc?agc?atc?gac?ggc?acc?gca?atc?tcc?act?ccc?ggc?gat?gca?caa 643

Leu?Leu?Ser?Ile?Asp?Gly?Thr?Ala?Ile?Ser?Thr?Pro?Gly?Asp?Ala?Gln

170 175 180

acc?atc?gtg?cga?tcg?aaa?gct?ccc?ggc?gat?gag?atc?acg?att?tcc?tac 691

Thr?Ile?Val?Arg?Ser?Lys?Ala?Pro?Gly?Asp?Glu?Ile?Thr?Ile?Ser?Tyr

185 190 195

gag?aga?aac?gat?gcg?gaa?tct?caa?gca?acc?atc?act?ttg?agg?gaa?cac 739

Glu?Arg?Asn?Asp?Ala?Glu?Ser?Gln?Ala?Thr?Ile?Thr?Leu?Arg?Glu?His

200 205 210

ccg?gat?gat?tct?tcg?gtg?gcg?ttg?ttg?ggt?att?tca?atg?ttg?tcg?gtg 787

Pro?Asp?Asp?Ser?Ser?Val?Ala?Leu?Leu?Gly?Ile?Ser?Met?Leu?Ser?Val

215 220 225

cct?tcg?agc?gcg?att?gag?gtt?gat?tac?aac?ttg?gaa?gat?atc?ggt?ggt 835

Pro?Ser?Ser?Ala?Ile?Glu?Val?Asp?Tyr?Asn?Leu?Glu?Asp?Ile?Gly?Gly

230 235 240 245

ccg?agc?gct?ggc?atg?atg?ttt?tcg?ttg?gcg?gtc?gtc?gat?aag?ctt?tcg 883

Pro?Ser?Ala?Gly?Met?Met?Phe?Ser?Leu?Ala?Val?Val?Asp?Lys?Leu?Ser

250 255 260

cct?ggc?gcg?ctg?aat?ggt?ggc?aag?ttt?gtc?gct?ggc?act?ggc?acc?atc 931

Pro?Gly?Ala?Leu?Asn?Gly?Gly?Lys?Phe?Val?Ala?Gly?Thr?Gly?Thr?Ile

265 270 275

gcg?gag?gac?ggg?tcg?gtg?ggc?ccg?att?ggc?ggt?att?gcg?cac?aag?gtg 979

Ala?Glu?Asp?Gly?Ser?Val?Gly?Pro?Ile?Gly?Gly?Ile?Ala?His?Lys?Val

280 285 290

cgc?gct?gcg?gag?gac?gcg?ggc?gcg?gaa?gtg?ttt?ttg?agc?cct?gcg?gac 1027

Arg?Ala?Ala?Glu?Asp?Ala?Gly?Ala?Glu?Val?Phe?Leu?Ser?Pro?Ala?Asp

295 300 305

aat?tgc?gcg?gag?gcg?atg?agt?gcg?aag?cct?cag?gat?atg?acg?atc?ttg 1075

Asn?Cys?Ala?Glu?Ala?Met?Ser?Ala?Lys?Pro?Gln?Asp?Met?Thr?Ile?Leu

310 315 320 325

aag?gtg?gat?tcg?ttg?tct?cag?gca?atc?gat?cag?atg?gct?gcc?tac?aac 1123

Lys?Val?Asp?Ser?Leu?Ser?Gln?Ala?Ile?Asp?Gln?Met?Ala?Ala?Tyr?Asn

330 335 340

gag?ggc?tct?gat?ttc?cag?acg?tgt?ggc?tagtttttag?acgctgaggt 1170

Glu?Gly?Ser?Asp?Phe?Gln?Thr?Cys?Gly

345 350

ttc

1173

<210>40

<211>350

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>40

Val?Asn?Arg?Arg?Ile?Lys?Thr?Leu?Thr?Trp?Gly?Ala?Ile?Pro?Leu?Val

1 5 10 15

Leu?Leu?Ala?Ser?Leu?Val?Ser?Ile?Asp?His?Ile?Pro?Gly?Thr?Asn?Ile

20 25 30

Asn?Leu?Ser?Val?Pro?Tyr?Ala?Ala?Glu?Gly?Pro?Gly?Pro?Thr?Ile?Asn

35 40 45

Thr?Leu?Gly?Gln?Val?Asp?Gly?Glu?Asp?Val?Val?Ser?Ile?Ser?Ser?Ala

50 55 60

Asp?Leu?Asp?Glu?Thr?Glu?Gly?Asn?Leu?Asn?Met?Thr?Thr?Val?Ser?Val

65 70 75 80

Arg?Ser?Gly?Met?Thr?Leu?Ser?Gln?Val?Ile?Ser?Arg?Trp?Leu?Phe?Thr

85 90 95

Asp?Asp?Thr?Ile?Val?Pro?Ile?Glu?Gln?Val?Phe?Pro?Pro?Gly?Gln?Ser

100 105 110

Thr?Glu?Glu?Val?Glu?Glu?Ser?Asn?Arg?Thr?Ala?Phe?Ile?Ser?Ser?Glu

115 120 125

Ser?Ser?Ala?Thr?Ile?Ala?Ala?Met?Asn?Tyr?Leu?Asn?Ile?Pro?Val?Glu

130 135 140

Val?Glu?Val?Ala?Glu?Val?Leu?Thr?Asp?Ser?Ala?Ala?Thr?Gly?Ile?Phe

145 150 155 160

Glu?Pro?Gly?Asp?Lys?Leu?Leu?Ser?Ile?Asp?Gly?Thr?Ala?Ile?Ser?Thr

165 170 175

Pro?Gly?Asp?Ala?Gln?Thr?Ile?Val?Arg?Ser?Lys?Ala?Pro?Gly?Asp?Glu

180 185 190

Ile?Thr?Ile?Ser?Tyr?Glu?Arg?Asn?Asp?Ala?Glu?Ser?Gln?Ala?Thr?Ile

195 200 205

Thr?Leu?Arg?Glu?His?Pro?Asp?Asp?Ser?Ser?Val?Ala?Leu?Leu?Gly?Ile

210 215 220

Ser?Met?Leu?Ser?Val?Pro?Ser?Ser?Ala?Ile?Glu?Val?Asp?Tyr?Asn?Leu

225 230 235 240

Glu?Asp?Ile?Gly?Gly?Pro?Ser?Ala?Gly?Met?Met?Phe?Ser?Leu?Ala?Val

245 250 255

Val?Asp?Lys?Leu?Ser?Pro?Gly?Ala?Leu?Asn?Gly?Gly?Lys?Phe?Val?Ala

260 265 270

Gly?Thr?Gly?Thr?Ile?Ala?Glu?Asp?Gly?Ser?Val?Gly?Pro?Ile?Gly?Gly

275 280 285

Ile?Ala?His?Lys?Val?Arg?Ala?Ala?Glu?Asp?Ala?Gly?Ala?Glu?Val?Phe

290 295 300

Leu?Ser?Pro?Ala?Asp?Asn?Cys?Ala?Glu?Ala?Met?Ser?Ala?Lys?Pro?Gln

305 310 315 320

Asp?Met?Thr?Ile?Leu?Lys?Val?Asp?Ser?Leu?Ser?Gln?Ala?Ile?Asp?Gln

325 330 335

Met?Ala?Ala?Tyr?Asn?Glu?Gly?Ser?Asp?Phe?Gln?Thr?Cys?Gly

340 345 350

<210>41

<211>1119

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1096)

<223>RXA01654

<400>41

cttttgctgt?tatgaaagtg?aactaaagat?atctatgcgc?agaccggtct?cacgccgcgc?60

catttttgca?acatctgttt?tggttgcggg?ggtgagcatc?atg?tca?cct?tcg?gcc 115

Met?Ser?Pro?Ser?Ala

1 5

aac?gca?gct?gag?gct?ccg?gca?tcg?gaa?tgg?gtg?aat?acg?aca?gcg?atc 163

Asn?Ala?Ala?Glu?Ala?Pro?Ala?Ser?Glu?Trp?Val?Asn?Thr?Thr?Ala?Ile

10 15 20

gta?gat?caa?gcg?aat?gct?cag?ttg?tcg?cag?ttt?ggc?gtg?agt?ctt?gac 211

Val?Asp?Gln?Ala?Asn?Ala?Gln?Leu?Ser?Gln?Phe?Gly?Val?Ser?Leu?Asp

25 30 35

cga?agt?gca?gca?gaa?ctt?ttt?gat?gat?cag?gca?aac?tcc?caa?att?gat 259

Arg?Ser?Ala?Ala?Glu?Leu?Phe?Asp?Asp?Gln?Ala?Asn?Ser?Gln?Ile?Asp

40 45 50

gca?gcg?ctt?tca?ccg?tat?gcc?gat?aag?gtt?cca?acc?tct?ggc?ggc?cag 307

Ala?Ala?Leu?Ser?Pro?Tyr?Ala?Asp?Lys?Val?Pro?Thr?Ser?Gly?Gly?Gln

55 60 65

gta?gtc?gag?caa?agt?ctt?cag?gtt?gtg?gag?cag?gaa?gtt?caa?aag?gca 355

Val?Val?Glu?Gln?Ser?Leu?Gln?Val?Val?Glu?Gln?Glu?Val?Gln?Lys?Ala

70 75 80 85

ctg?ccc?aac?tat?gaa?atc?cgt?acc?gat?ctg?caa?tcc?cag?gtg?atg?ggt 403

Leu?Pro?Asn?Tyr?Glu?Ile?Arg?Thr?Asp?Leu?Gln?Ser?Gln?Val?Met?Gly

90 95 100

gca?act?cta?gga?gag?gtg?ctg?cac?cga?gtt?cct?gga?tca?tgg?ttt?gat 451

Ala?Thr?Leu?Gly?Glu?Val?Leu?His?Arg?Val?Pro?Gly?Ser?Trp?Phe?Asp

105 110 115

gcg?cca?gca?gtt?cct?gaa?gaa?tcc?agg?att?gta?gag?gaa?cag?ggt?aaa 499

Ala?Pro?Ala?Val?Pro?Glu?Glu?Ser?Arg?Ile?Val?Glu?Glu?Gln?Gly?Lys

120 125 130

tcc?ctg?tat?ggg?ccc?ggt?acc?ccg?atc?tat?ctc?aac?gga?aat?tcc?atg 547

Ser?Leu?Tyr?Gly?Pro?Gly?Thr?Pro?Ile?Tyr?Leu?Asn?Gly?Asn?Ser?Met

135 140 145

tgc?acg?ctt?gcg?gtg?act?gga?act?gat?gca?gat?ggg?cgc?aag?atc?ggt 595

Cys?Thr?Leu?Ala?Val?Thr?Gly?Thr?Asp?Ala?Asp?Gly?Arg?Lys?Ile?Gly

150 155 160 165

atc?act?gca?ggt?cac?tgt?gga?aaa?tcg?ggc?gat?gca?gtc?cgt?tcg?gct 643

Ile?Thr?Ala?Gly?His?Cys?Gly?Lys?Ser?Gly?Asp?Ala?Val?Arg?Ser?Ala

170 175 180

gac?tcc?ttc?tgg?gtc?ggc?gat?acc?gga?aca?gtg?gtg?tac?aac?gcg?cct 691

Asp?Ser?Phe?Trp?Val?Gly?Asp?Thr?Gly?Thr?Val?Val?Tyr?Asn?Ala?Pro

185 190 195

aac?gct?gac?tac?tcc?gtg?atc?gag?ttc?ggt?tcc?aat?gca?gag?ttg?agc 739

Asn?Ala?Asp?Tyr?Ser?Val?Ile?Glu?Phe?Gly?Ser?Asn?Ala?Glu?Leu?Ser

200 205 210

aat?acc?tac?aac?ggt?gtc?acc?gcg?aat?gct?gtc?ggc?ggt?ggc?gtg?act 787

Asn?Thr?Tyr?Asn?Gly?Val?Thr?Ala?Asn?Ala?Val?Gly?Gly?Gly?Val?Thr

215 220 225

aat?ggc?caa?gaa?gta?tgc?aaa?aac?gga?gtt?gct?act?ggc?tac?acc?tgt 835

Asn?Gly?Gln?Glu?Val?Cys?Lys?Asn?Gly?Val?Ala?Thr?Gly?Tyr?Thr?Cys

230 235 240 245

ggt?ttg?gtg?tgg?act?gct?gat?gag?cgc?atg?acg?atg?tct?cag?gtg?tgt 883

Gly?Leu?Val?Trp?Thr?Ala?Asp?Glu?Arg?Met?Thr?Met?Ser?Gln?Val?Cys

250 255 260

gcg?ggt?cgt?ggt?gat?tcg?ggt?gct?ccg?ctg?att?gca?gat?ggt?cgt?gtg 931

Ala?Gly?Arg?Gly?Asp?Ser?Gly?Ala?Pro?Leu?Ile?Ala?Asp?Gly?Arg?Val

265 270 275

gtt?ggt?ctt?gta?tct?ggt?ggt?gta?att?cct?gat?tac?aac?ctg?gca?tgc 979

Val?Gly?Leu?Val?Ser?Gly?Gly?Val?Ile?Pro?Asp?Tyr?Asn?Leu?Ala?Cys

280 285 290

gcc?act?ccg?ttg?cag?gga?cct?ttc?ttc?atg?cca?acg?ctg?tca?gtg?aac 1027

Ala?Thr?Pro?Leu?Gln?Gly?Pro?Phe?Phe?Met?Pro?Thr?Leu?Ser?Val?Asn

295 300 305

atg?gat?act?gtc?cta?act?gat?ttg?gat?tcg?cag?gat?ctt?ccc?ggt?cga 1075

Met?Asp?Thr?Val?Leu?Thr?Asp?Leu?Asp?Ser?Gln?Asp?Leu?Pro?Gly?Arg

310 315 320 325

ggt?ttt?cag?cca?act?gct?gga?tagaatttag?aaaatccgcc?gtt 1119

Gly?Phe?Gln?Pro?Thr?Ala?Gly

330

<210>42

<211>332

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>42

Met?Ser?Pro?Ser?Ala?Asn?Ala?Ala?Glu?Ala?Pro?Ala?Ser?Glu?Trp?Val

1 5 10 15

Asn?Thr?Thr?Ala?Ile?Val?Asp?Gln?Ala?Asn?Ala?Gln?Leu?Ser?Gln?Phe

20 25 30

Gly?Val?Ser?Leu?Asp?Arg?Ser?Ala?Ala?Glu?Leu?Phe?Asp?Asp?Gln?Ala

35 40 45

Asn?Ser?Gln?Ile?Asp?Ala?Ala?Leu?Ser?Pro?Tyr?Ala?Asp?Lys?Val?Pro

50 55 60

Thr?Ser?Gly?Gly?Gln?Val?Val?Glu?Gln?Ser?Leu?Gln?Val?Val?Glu?Gln

65 70 75 80

Glu?Val?Gln?Lys?Ala?Leu?Pro?Asn?Tyr?Glu?Ile?Arg?Thr?Asp?Leu?Gln

85 90 95

Ser?Gln?Val?Met?Gly?Ala?Thr?Leu?Gly?Glu?Val?Leu?His?Arg?Val?Pro

100 105 110

Gly?Ser?Trp?Phe?Asp?Ala?Pro?Ala?Val?Pro?Glu?Glu?Ser?Arg?Ile?Val

115 120 125

Glu?Glu?Gln?Gly?Lys?Ser?Leu?Tyr?Gly?Pro?Gly?Thr?Pro?Ile?Tyr?Leu

130 135 140

Asn?Gly?Asn?Ser?Met?Cys?Thr?Leu?Ala?Val?Thr?Gly?Thr?Asp?Ala?Asp

145 150 155 160

Gly?Arg?Lys?Ile?Gly?Ile?Thr?Ala?Gly?His?Cys?Gly?Lys?Ser?Gly?Asp

165 170 175

Ala?Val?Arg?Ser?Ala?Asp?Ser?Phe?Trp?Val?Gly?Asp?Thr?Gly?Thr?Val

180 185 190

Val?Tyr?Asn?Ala?Pro?Asn?Ala?Asp?Tyr?Ser?Val?Ile?Glu?Phe?Gly?Ser

195 200 205

Asn?Ala?Glu?Leu?Ser?Asn?Thr?Tyr?Asn?Gly?Val?Thr?Ala?Asn?Ala?Val

210 215 220

Gly?Gly?Gly?Val?Thr?Asn?Gly?Gln?Glu?Val?Cys?Lys?Asn?Gly?Val?Ala

225 230 235 240

Thr?Gly?Tyr?Thr?Cys?Gly?Leu?Val?Trp?Thr?Ala?Asp?Glu?Arg?Met?Thr

245 250 255

Met?Ser?Gln?Val?Cys?Ala?Gly?Arg?Gly?Asp?Ser?Gly?Ala?Pro?Leu?Ile

260 265 270

Ala?Asp?Gly?Arg?Val?Val?Gly?Leu?Val?Ser?Gly?Gly?Val?Ile?Pro?Asp

275 280 285

Tyr?Asn?Leu?Ala?Cys?Ala?Thr?Pro?Leu?Gln?Gly?Pro?Phe?Phe?Met?Pro

290 295 300

Thr?Leu?Ser?Val?Asn?Met?Asp?Thr?Val?Leu?Thr?Asp?Leu?Asp?Ser?Gln

305 310 315 320

Asp?Leu?Pro?Gly?Arg?Gly?Phe?Gln?Pro?Thr?Ala?Gly

325 330

<210>43

<211>2049

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(2026)

<223>RXN01868

<400>43

tgacaggcta?ccttctgggg?tggacatgat?ccccaacgct?caacccactt?gtggcaccaa?60

ccacaaaccc?tgtggcggta?aatcccctag?agtaggccac?atg?aag?gat?ctt?tat 115

Met?Lys?Asp?Leu?Tyr

1 5

cgc?ttt?gtc?aat?ggc?ctg?tgg?ctt?gac?acc?cac?atc?att?ccc?gac?gat 163

Arg?Phe?Val?Asn?Gly?Leu?Trp?Leu?Asp?Thr?His?Ile?Ile?Pro?Asp?Asp

10 15 20

cgc?gcg?gtg?gac?ggc?acg?ttc?cac?aag?ctg?cgc?gat?gat?gct?gaa?gaa 211

Arg?Ala?Val?Asp?Gly?Thr?Phe?His?Lys?Leu?Arg?Asp?Asp?Ala?Glu?Glu

25 30 35

gac?gtc?cat?gag?atc?gtc?aag?gaa?gac?act?gga?cgc?gca?ggc?aca?ctt 259

Asp?Val?His?Glu?Ile?Val?Lys?Glu?Asp?Thr?Gly?Arg?Ala?Gly?Thr?Leu

40 45 50

tat?gcc?tca?ttt?atg?gat?act?gac?gcc?atc?aac?gct?gct?ggt?gtt?gca 307

Tyr?Ala?Ser?Phe?Met?Asp?Thr?Asp?Ala?Ile?Asn?Ala?Ala?Gly?Val?Ala

55 60 65

ccg?ctc?gat?gcg?gat?ctg?aac?agg?ctg?tct?gtt?gct?aac?tca?tcg?ttt 355

Pro?Leu?Asp?Ala?Asp?Leu?Asn?Arg?Leu?Ser?Val?Ala?Asn?Ser?Ser?Phe

70 75 80 85

ttc?gca?gct?gct?ctc?ggc?gaa?ctg?gac?cgt?gaa?ggc?gtt?ggc?gcg?cca 403

Phe?Ala?Ala?Ala?Leu?Gly?Glu?Leu?Asp?Arg?Glu?Gly?Val?Gly?Ala?Pro

90 95 100

gta?ggt?ttc?tgg?gtg?gag?aag?gat?tct?tcc?tcc?aac?gaa?tcc?gtc?gcc 451

Val?Gly?Phe?Trp?Val?Glu?Lys?Asp?Ser?Ser?Ser?Asn?Glu?Ser?Val?Ala

105 110 115

tat?gtc?atc?cag?tcc?ggc?ctc?ggc?ctg?ccc?gat?gag?gct?tat?tac?cgc 499

Tyr?Val?Ile?Gln?Ser?Gly?Leu?Gly?Leu?Pro?Asp?Glu?Ala?Tyr?Tyr?Arg

120 125 130

gag?gag?gca?cac?gcc?gaa?act?ctc?gcg?gcc?tac?aaa?gag?cac?gtt?gag 547

Glu?Glu?Ala?His?Ala?Glu?Thr?Leu?Ala?Ala?Tyr?Lys?Glu?His?Val?Glu

135 140 145

cgc?atg?ctc?ggc?tac?ttg?gat?aac?agc?cgc?ctc?ttc?ggt?ctg?tcg?gct 595

Arg?Met?Leu?Gly?Tyr?Leu?Asp?Asn?Ser?Arg?Leu?Phe?Gly?Leu?Ser?Ala

150 155 160 165

gct?tcc?gct?gcc?gca?cga?att?gtc?gcc?ctg?gaa?acg?gaa?atc?gct?gct 643

Ala?Ser?Ala?Ala?Ala?Arg?Ile?Val?Ala?Leu?Glu?Thr?Glu?Ile?Ala?Ala

170 175 180

ggc?cac?tgg?gat?gtc?gtg?aag?acc?cgc?gac?gcc?gta?gcc?acc?tac?aac 691

Gly?His?Trp?Asp?Val?Val?Lys?Thr?Arg?Asp?Ala?Val?Ala?Thr?Tyr?Asn

185 190 195

ccc?acc?gaa?ctc?ggc?gcg?ctg?cca?cca?aag?gtc?cgc?acg?ctg?ctc?agt 739

Pro?Thr?Glu?Leu?Gly?Ala?Leu?Pro?Pro?Lys?Val?Arg?Thr?Leu?Leu?Ser

200 205 210

tcc?gca?ggc?ctc?ccg?gac?cag?cgc?ctg?gta?tcg?atg?atg?ccg?tca?tac 787

Ser?Ala?Gly?Leu?Pro?Asp?Gln?Arg?Leu?Val?Ser?Met?Met?Pro?Ser?Tyr

215 220 225

ctc?gac?cac?ctc?aac?ggc?ttg?ctt?gtc?gac?gac?cgc?ctc?ccc?gat?tgg 835

Leu?Asp?His?Leu?Asn?Gly?Leu?Leu?Val?Asp?Asp?Arg?Leu?Pro?Asp?Trp

230 235 240 245

cag?cta?tgg?gca?acc?tgg?cac?atc?ttg?agg?tct?cga?gca?gga?ctg?ttg 883

Gln?Leu?Trp?Ala?Thr?Trp?His?Ile?Leu?Arg?Ser?Arg?Ala?Gly?Leu?Leu

250 255 260

acc?gag?gaa?att?agc?caa?gca?aac?ttc?gac?ttc?tat?ggc?acc?aaa?ctg 931

Thr?Glu?Glu?Ile?Ser?Gln?Ala?Asn?Phe?Asp?Phe?Tyr?Gly?Thr?Lys?Leu

265 270 275

tcc?ggc?gcc?acc?gag?caa?aaa?gat?cga?tgg?aag?cgt?gct?gtc?ggc?ctg 979

Ser?Gly?Ala?Thr?Glu?Gln?Lys?Asp?Arg?Trp?Lys?Arg?Ala?Val?Gly?Leu

280 285 290

gca?gag?cgc?atg?gtg?ggc?gag?gaa?atc?ggg?caa?cga?ttc?gtc?gaa?agg 1027

Ala?Glu?Arg?Met?Val?Gly?Glu?Glu?Ile?Gly?Gln?Arg?Phe?Val?Glu?Arg

295 300 305

cat?ttt?cct?gca?agc?tcc?aag?gag?cac?atg?ctt?gag?ctc?gtc?gac?tac 1075

His?Phe?Pro?Ala?Ser?Ser?Lys?Glu?His?Met?Leu?Glu?Leu?Val?Asp?Tyr

310 315 320 325

ctg?gtt?gcc?gcc?tac?cgt?gat?cgc?att?tcc?aac?ctc?gaa?tgg?atg?acg 1123

Leu?Val?Ala?Ala?Tyr?Arg?Asp?Arg?Ile?Ser?Asn?Leu?Glu?Trp?Met?Thr

330 335 340

ccc?gcc?acc?cgc?gag?cgt?gcc?ctg?gaa?aag?ttg?ggc?aaa?ttc?aac?gcg 1171

Pro?Ala?Thr?Arg?Glu?Arg?Ala?Leu?Glu?Lys?Leu?Gly?Lys?Phe?Asn?Ala

345 350 355

aaa?atc?ggc?tac?ccc?gac?aag?tgg?cgc?tcc?tac?gaa?ggc?ctc?gaa?ttc 1219

Lys?Ile?Gly?Tyr?Pro?Asp?Lys?Trp?Arg?Ser?Tyr?Glu?Gly?Leu?Glu?Phe

360 365 370

ggc?tcc?gac?ctg?gtg?gac?aac?tcc?cgc?aag?ggc?tcc?gcg?ttc?ctc?cat 1267

Gly?Ser?Asp?Leu?Val?Asp?Asn?Ser?Arg?Lys?Gly?Ser?Ala?Phe?Leu?His

375 380 385

gac?tat?gag?ctg?ggc?aag?atc?ggc?aaa?cca?gcc?gac?cgc?gac?gaa?tgg 1315

Asp?Tyr?Glu?Leu?Gly?Lys?Ile?Gly?Lys?Pro?Ala?Asp?Arg?Asp?Glu?Trp

390 395 400 405

gtc?acc?acc?cca?caa?acc?gtc?aac?gcc?ttc?tac?aac?ccc?gtg?gtc?aac 1363

Val?Thr?Thr?Pro?Gln?Thr?Val?Asn?Ala?Phe?Tyr?Asn?Pro?Val?Val?Asn

410 415 420

gac?atc?acc?ttc?ccc?gca?gcc?atc?ctg?cgc?gca?cca?ttc?ttc?gac?ccc 1411

Asp?Ile?Thr?Phe?Pro?Ala?Ala?Ile?Leu?Arg?Ala?Pro?Phe?Phe?Asp?Pro

425 430 435

gaa?gca?gaa?gcc?gca?gaa?aac?ttc?ggt?gca?atc?ggt?gct?gtg?atc?gga 1459

Glu?Ala?Glu?Ala?Ala?Glu?Asn?Phe?Gly?Ala?Ile?Gly?Ala?Val?Ile?Gly

440 445 450

cac?gaa?atc?ggc?cac?ggc?ttt?gac?gat?caa?ggc?agc?caa?tac?gac?ggc 1507

His?Glu?Ile?Gly?His?Gly?Phe?Asp?Asp?Gln?Gly?Ser?Gln?Tyr?Asp?Gly

455 460 465

gac?ggc?aac?ctc?aac?tcc?tgg?tgg?acc?gac?gaa?gac?cgc?tcc?gca?ttc 1555

Asp?Gly?Asn?Leu?Asn?Ser?Trp?Trp?Thr?Asp?Glu?Asp?Arg?Ser?Ala?Phe

470 475 480 485

gag?cag?ctc?acc?tca?cgt?ctg?gtc?acc?caa?ttc?agc?gga?ctc?gtc?cct 1603

Glu?Gln?Leu?Thr?Ser?Arg?Leu?Val?Thr?Gln?Phe?Ser?Gly?Leu?Val?Pro

490 495 500

gcc?gtc?ctg?acc?tct?gaa?gga?atc?gac?acc?gac?ggc?gtc?aac?ggt?gaa 1651

Ala?Val?Leu?Thr?Ser?Glu?Gly?Ile?Asp?Thr?Asp?Gly?Val?Asn?Gly?Glu

505 510 515

ttc?act?ctc?ggc?gaa?aac?atc?ggt?gac?ctc?ggc?gga?ttg?ggc?atc?gct 1699

Phe?Thr?Leu?Gly?Glu?Asn?Ile?Gly?Asp?Leu?Gly?Gly?Leu?Gly?Ile?Ala

520 525 530

gtc?gtt?gcc?tac?gaa?aag?tac?ctc?gca?gac?cgt?ggc?caa?acc?ttt?gaa 1747

Val?Val?Ala?Tyr?Glu?Lys?Tyr?Leu?Ala?Asp?Arg?Gly?Gln?Thr?Phe?Glu

535 540 545

acc?tca?cca?gtc?caa?aaa?ttc?gaa?gca?gaa?ggc?gcc?gag?gaa?ggc?ctg 1795

Thr?Ser?Pro?Val?Gln?Lys?Phe?Glu?Ala?Glu?Gly?Ala?Glu?Glu?Gly?Leu

550 555 560 565

gcc?gag?caa?gaa?ttc?aac?ggt?ctc?caa?cgc?ctc?ttc?ctg?tcc?tgg?gct 1843

Ala?Glu?Gln?Glu?Phe?Asn?Gly?Leu?Gln?Arg?Leu?Phe?Leu?Ser?Trp?Ala

570 575 580

cgc?gtg?tgg?cgc?acc?aaa?atc?cgc?cca?cag?atg?gcc?gtc?caa?tac?ctg 1891

Arg?Val?Trp?Arg?Thr?Lys?Ile?Arg?Pro?Gln?Met?Ala?Val?Gln?Tyr?Leu

585 590 595

gcc?atc?gac?cca?cac?tcc?cct?gca?gaa?ttc?cgc?tgc?aat?gtc?atc?gcc 1939

Ala?Ile?Asp?Pro?His?Ser?Pro?Ala?Glu?Phe?Arg?Cys?Asn?Val?Ile?Ala

600 605 610

gga?aac?gtc?gct?gaa?ttc?tac?gaa?gca?ttc?gac?gtc?ccc?gaa?gat?gca 1987

Gly?Asn?Val?Ala?Glu?Phe?Tyr?Glu?Ala?Phe?Asp?Val?Pro?Glu?Asp?Ala

615 620 625

cct?gtg?tac?atc?aag?cca?gaa?gag?cgc?cta?gct?atc?tgg?tagttgttag 2036

Pro?Val?Tyr?Ile?Lys?Pro?Glu?Glu?Arg?Leu?Ala?Ile?Trp

630 635 640

ttggtattga?aaa 2049

<210>44

<211>642

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>44

Met?Lys?Asp?Leu?Tyr?Arg?Phe?Val?Asn?Gly?Leu?Trp?Leu?Asp?Thr?His

1 5 10 15

Ile?Ile?Pro?Asp?Asp?Arg?Ala?Val?Asp?Gly?Thr?Phe?His?Lys?Leu?Arg

20 25 30

Asp?Asp?Ala?Glu?Glu?Asp?Val?His?Glu?Ile?Val?Lys?Glu?Asp?Thr?Gly

35 40 45

Arg?Ala?Gly?Thr?Leu?Tyr?Ala?Ser?Phe?Met?Asp?Thr?Asp?Ala?Ile?Asn

50 55 60

Ala?Ala?Gly?Val?Ala?Pro?Leu?Asp?Ala?Asp?Leu?Asn?Arg?Leu?Ser?Val

65 70 75 80

Ala?Asn?Ser?Ser?Phe?Phe?Ala?Ala?Ala?Leu?Gly?Glu?Leu?Asp?Arg?Glu

85 90 95

Gly?Val?Gly?Ala?Pro?Val?Gly?Phe?Trp?Val?Glu?Lys?Asp?Ser?Ser?Ser

100 105 110

Asn?Glu?Ser?Val?Ala?Tyr?Val?Ile?Gln?Ser?Gly?Leu?Gly?Leu?Pro?Asp

115 120 125

Glu?Ala?Tyr?Tyr?Arg?Glu?Glu?Ala?His?Ala?Glu?Thr?Leu?Ala?Ala?Tyr

130 135 140

Lys?Glu?His?Val?Glu?Arg?Met?Leu?Gly?Tyr?Leu?Asp?Asn?Ser?Arg?Leu

145 150 155 160

Phe?Gly?Leu?Ser?Ala?Ala?Ser?Ala?Ala?Ala?Arg?Ile?Val?Ala?Leu?Glu

165 170 175

Thr?Glu?Ile?Ala?Ala?Gly?His?Trp?Asp?Val?Val?Lys?Thr?Arg?Asp?Ala

180 185 190

Val?Ala?Thr?Tyr?Asn?Pro?Thr?Glu?Leu?Gly?Ala?Leu?Pro?Pro?Lys?Val

195 200 205

Arg?Thr?Leu?Leu?Ser?Ser?Ala?Gly?Leu?Pro?Asp?Gln?Arg?Leu?Val?Ser

210 215 220

Met?Met?Pro?Ser?Tyr?Leu?Asp?His?Leu?Asn?Gly?Leu?Leu?Val?Asp?Asp

225 230 235 240

Arg?Leu?Pro?Asp?Trp?Gln?Leu?Trp?Ala?Thr?Trp?His?Ile?Leu?Arg?Ser

245 250 255

Arg?Ala?Gly?Leu?Leu?Thr?Glu?Glu?Ile?Ser?Gln?Ala?Asn?Phe?Asp?Phe

260 265 270

Tyr?Gly?Thr?Lys?Leu?Ser?Gly?Ala?Thr?Glu?Gln?Lys?Asp?Arg?Trp?Lys

275 280 285

Arg?Ala?Val?Gly?Leu?Ala?Glu?Arg?Met?Val?Gly?Glu?Glu?Ile?Gly?Gln

290 295 300

Arg?Phe?Val?Glu?Arg?His?Phe?Pro?Ala?Ser?Ser?Lys?Glu?His?Met?Leu

305 310 315 320

Glu?Leu?Val?Asp?Tyr?Leu?Val?Ala?Ala?Tyr?Arg?Asp?Arg?Ile?Ser?Asn

325 330 335

Leu?Glu?Trp?Met?Thr?Pro?Ala?Thr?Arg?Glu?Arg?Ala?Leu?Glu?Lys?Leu

340 345 350

Gly?Lys?Phe?Asn?Ala?Lys?Ile?Gly?Tyr?Pro?Asp?Lys?Trp?Arg?Ser?Tyr

355 360 365

Glu?Gly?Leu?Glu?Phe?Gly?Ser?Asp?Leu?Val?Asp?Asn?Ser?Arg?Lys?Gly

370 375 380

Ser?Ala?Phe?Leu?His?Asp?Tyr?Glu?Leu?Gly?Lys?Ile?Gly?Lys?Pro?Ala

385 390 395 400

Asp?Arg?Asp?Glu?Trp?Val?Thr?Thr?Pro?Gln?Thr?Val?Asn?Ala?Phe?Tyr

405 410 415

Asn?Pro?Val?Val?Asn?Asp?Ile?Thr?Phe?Pro?Ala?Ala?Ile?Leu?Arg?Ala

420 425 430

Pro?Phe?Phe?Asp?Pro?Glu?Ala?Glu?Ala?Ala?Glu?Asn?Phe?Gly?Ala?Ile

435 440 445

Gly?Ala?Val?Ile?Gly?His?Glu?Ile?Gly?His?Gly?Phe?Asp?Asp?Gln?Gly

450 455 460

Ser?Gln?Tyr?Asp?Gly?Asp?Gly?Asn?Leu?Asn?Ser?Trp?Trp?Thr?Asp?Glu

465 470 475 480

Asp?Arg?Ser?Ala?Phe?Glu?Gln?Leu?Thr?Ser?Arg?Leu?Val?Thr?Gln?Phe

485 490 495

Ser?Gly?Leu?Val?Pro?Ala?Val?Leu?Thr?Ser?Glu?Gly?Ile?Asp?Thr?Asp

500 505 510

Gly?Val?Asn?Gly?Glu?Phe?Thr?Leu?Gly?Glu?Asn?Ile?Gly?Asp?Leu?Gly

515 520 525

Gly?Leu?Gly?Ile?Ala?Val?Val?Ala?Tyr?Glu?Lys?Tyr?Leu?Ala?Asp?Arg

530 535 540

Gly?Gln?Thr?Phe?Glu?Thr?Ser?Pro?Val?Gln?Lys?Phe?Glu?Ala?Glu?Gly

545 550 555 560

Ala?Glu?Glu?Gly?Leu?Ala?Glu?Gln?Glu?Phe?Asn?Gly?Leu?Gln?Arg?Leu

565 570 575

Phe?Leu?Ser?Trp?Ala?Arg?Val?Trp?Arg?Thr?Lys?Ile?Arg?Pro?Gln?Met

580 585 590

Ala?Val?Gln?Tyr?Leu?Ala?Ile?Asp?Pro?His?Ser?Pro?Ala?Glu?Phe?Arg

595 600 605

Cys?Asn?Val?Ile?Ala?Gly?Asn?Val?Ala?Glu?Phe?Tyr?Glu?Ala?Phe?Asp

610 615 620

Val?Pro?Glu?Asp?Ala?Pro?Val?Tyr?Ile?Lys?Pro?Glu?Glu?Arg?Leu?Ala

625 630 635 640

Ile?Trp

<210>45

<211>l734

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1711)

<223>FRXA01868

<400>45

atgcggatct?gaacaggctg?tctgttgcta?actcatcgtt?ttcgcagctg?ctctcggcga?60

actggaccgt?gaaggcgttg?gcgcgccagt?aggtttctgg?gtg?gag?aag?gat?tct 115

Val?Glu?Lys?Asp?Ser

1 5

tcc?tcc?aac?gaa?tcc?gtc?gcc?tat?gtc?atc?cag?tcc?ggc?ctc?ggc?ctg 163

Ser?Ser?Asn?Glu?Ser?Val?Ala?Tyr?Val?Ile?Gln?Ser?Gly?Leu?Gly?Leu

10 15 20

ccc?gat?gag?gct?tat?tac?cgc?gag?gag?gca?cac?gcc?gaa?act?ctc?gcg 211

Pro?Asp?Glu?Ala?Tyr?Tyr?Arg?Glu?Glu?Ala?His?Ala?Glu?Thr?Leu?Ala

25 30 35

gcc?tac?aaa?gag?cac?gtt?gag?cgc?atg?ctc?ggc?tac?ttg?gat?aac?agc 259

Ala?Tyr?Lys?Glu?His?Val?Glu?Arg?Met?Leu?Gly?Tyr?Leu?Asp?Asn?Ser

40 45 50

cgc?crc?ttc?ggt?ctg?tcg?gct?gct?tcc?gct?gcc?gca?cga?att?gtc?gcc 307

Arg?Leu?Phe?Gly?Leu?Ser?Ala?Ala?Ser?Ala?Ala?Ala?Arg?Ile?Val?Ala

55 60 65

ctg?gaa?acg?gaa?atc?gct?gct?ggc?cac?tgg?gat?gtc?gtg?aag?acc?cgc 355

Leu?Glu?Thr?Glu?Ile?Ala?Ala?Gly?His?Trp?Asp?Val?Val?Lys?Thr?Arg

70 75 80 85

gac?gcc?gta?gcc?acc?tac?aac?ccc?acc?gaa?ctc?ggc?gcg?ctg?cca?cca 403

Asp?Ala?Val?Ala?Thr?Tyr?Asn?Pro?Thr?Glu?Leu?Gly?Ala?Leu?Pro?Pro

90 95 100

aag?gtc?cgc?acg?ctg?ctc?agt?tcc?gca?ggc?ctc?ccg?gac?cag?cgc?ctg 451

Lys?Val?Arg?Thr?Leu?Leu?Ser?Ser?Ala?Gly?Leu?Pro?Asp?Gln?Arg?Leu

105 110 115

gta?tcg?atg?atg?ccg?tca?tac?ctc?gac?cac?ctc?aac?ggc?ttg?ctt?gtc 499

Val?Ser?Met?Met?Pro?Ser?Tyr?Leu?Asp?His?Leu?Asn?Gly?Leu?Leu?Val

120 125 130

gac?gac?cgc?ctc?ccc?gat?tgg?cag?cta?tgg?gca?acc?tgg?cac?atc?ttg 547

Asp?Asp?Arg?Leu?Pro?Asp?Trp?Gln?Leu?Trp?Ala?Thr?Trp?His?Ile?Leu

135 140 145

agg?tct?cga?gca?gga?ctg?ttg?acc?gag?gaa?att?agc?caa?gca?aac?ttc 595

Arg?Ser?Arg?Ala?Gly?Leu?Leu?Thr?Glu?Glu?Ile?Ser?Gln?Ala?Asn?Phe

150 155 160 165

gac?ttc?tat?ggc?acc?aaa?ctg?tcc?ggc?gcc?acc?gag?caa?aaa?gat?cga 643

Asp?Phe?Tyr?Gly?Thr?Lys?Leu?Ser?Gly?Ala?Thr?Glu?Gln?Lys?Asp?Arg

170 175 180

tgg?aag?cgt?gct?gtc?ggc?ctg?gca?gag?cgc?atg?gtg?ggc?gag?gaa?atc 691

Trp?Lys?Arg?Ala?Val?Gly?Leu?Ala?Glu?Arg?Met?Val?Gly?Glu?Glu?Ile

185 190 195

ggg?caa?cga?ttc?gtc?gaa?agg?cat?ttt?cct?gca?agc?tcc?aag?gag?cac 739

Gly?Gln?Arg?Phe?Val?Glu?Arg?His?Phe?Pro?Ala?Ser?Ser?Lys?Glu?His

200 205 210

atg?ctt?gag?ctc?gtc?gac?tac?ctg?gtt?gcc?gcc?tac?cgt?gat?cgc?att 787

Met?Leu?Glu?Leu?Val?Asp?Tyr?Leu?Val?Ala?Ala?Tyr?Arg?Asp?Arg?Ile

215 220 225

tcc?aac?ctc?gaa?tgg?atg?acg?ccc?gcc?acc?cgc?gag?cgt?gcc?ctg?gaa 835

Ser?Asn?Leu?Glu?Trp?Met?Thr?Pro?Ala?Thr?Arg?Glu?Arg?Ala?Leu?Glu

230 235 240 245

aag?ttg?ggc?aaa?ttc?aac?gcg?aaa?atc?ggc?tac?ccc?gac?aag?tgg?cgc 883

Lys?Leu?Gly?Lys?Phe?Asn?Ala?Lys?Ile?Gly?Tyr?Pro?Asp?Lys?Trp?Arg

250 255 260

tcc?tac?gaa?ggc?ctc?gaa?ttc?ggc?tcc?gac?ctg?gtg?gac?aac?tcc?cgc 931

Ser?Tyr?Glu?Gly?Leu?Glu?Phe?Gly?Ser?Asp?Leu?Val?Asp?Asn?Ser?Arg

265 270 275

aag?ggc?tcc?gcg?ttc?ctc?cat?gac?tat?gag?ctg?ggc?aag?atc?ggc?aaa 979

Lys?Gly?Ser?Ala?Phe?Leu?His?Asp?Tyr?Glu?Leu?Gly?Lys?Ile?Gly?Lys

280 285 290

cca?gcc?gac?cgc?gac?gaa?tgg?gtc?acc?acc?cca?caa?acc?gtc?aac?gcc 1027

Pro?Ala?Asp?Arg?Asp?Glu?Trp?Val?Thr?Thr?Pro?Gln?Thr?Val?Asn?Ala

295 300 305

ttc?tac?aac?ccc?gtg?gtc?aac?gac?atc?acc?ttc?ccc?gca?gcc?atc?ctg 1075

Phe?Tyr?Asn?Pro?Val?Val?Asn?Asp?Ile?Thr?Phe?Pro?Ala?Ala?Ile?Leu

310 315 320 325

cgc?gca?cca?ttc?ttc?gac?ccc?gaa?gca?gaa?gcc?gca?gaa?aac?ttc?ggt 1123

Arg?Ala?Pro?Phe?Phe?Asp?Pro?Glu?Ala?Glu?Ala?Ala?Glu?Asn?Phe?Gly

330 335 340

gca?atc?ggt?gct?gtg?atc?gga?cac?gaa?atc?ggc?cac?ggc?ttt?gac?gat 1171

Ala?Ile?Gly?Ala?Val?Ile?Gly?His?Glu?Ile?Gly?His?Gly?Phe?Asp?Asp

345 350 355

caa?ggc?agc?caa?tac?gac?ggc?gac?ggc?aac?ctc?aac?tcc?tgg?tgg?acc 1219

Gln?Gly?Ser?Gln?Tyr?Asp?Gly?Asp?Gly?Asn?Leu?Asn?Ser?Trp?Trp?Thr

360 365 370

gac?gaa?gac?cgc?tcc?gca?ttc?gag?cag?ctc?acc?tca?cgt?ctg?gtc?acc 1267

Asp?Glu?Asp?Arg?Ser?Ala?Phe?Glu?Gln?Leu?Thr?Ser?Arg?Leu?Val?Thr

375 380 385

caa?ttc?agc?gga?ctc?gtc?cct?gcc?gtc?ctg?acc?tct?gaa?gga?atc?gac 1315

Gln?Phe?Ser?Gly?Leu?Val?Pro?Ala?Val?Leu?Thr?Ser?Glu?Gly?Ile?Asp

390 395 400 405

acc?gac?ggc?gtc?aac?ggt?gaa?ttc?act?ctc?ggc?gaa?aac?atc?ggt?gac 1363

Thr?Asp?Gly?Val?Asn?Gly?Glu?Phe?Thr?Leu?Gly?Glu?Asn?Ile?Gly?Asp

410 415 420

ctc?ggc?gga?ttg?ggc?atc?gct?gtc?gtt?gcc?tac?gaa?aag?tac?ctc?gca 1411

Leu?Gly?Gly?Leu?Gly?Ile?Ala?Val?Val?Ala?Tyr?Glu?Lys?Tyr?Leu?Ala

425 430 435

gac?cgt?ggc?caa?acc?ttt?gaa?acc?tca?cca?gtc?caa?aaa?ttc?gaa?gca 1459

Asp?Arg?Gly?Gln?Thr?Phe?Glu?Thr?Ser?Pro?Val?Gln?Lys?Phe?Glu?Ala

440 445 450

gaa?ggc?gcc?gag?gaa?ggc?ctg?gcc?gag?caa?gaa?ttc?aac?ggt?ctc?caa 1507

Glu?Gly?Ala?Glu?Glu?Gly?Leu?Ala?Glu?Gln?Glu?Phe?Asn?Gly?Leu?Gln

455 460 465

cgc?crc?ttc?ctg?tcc?tgg?gct?cgc?gtg?tgg?cgc?acc?aaa?arc?cgc?cca 1555

Arg?Leu?Phe?Leu?Ser?Trp?Ala?Arg?Val?Trp?Arg?Thr?Lys?Ile?Arg?Pro

470 475 480 485

cag?atg?gcc?gtc?caa?tac?ctg?gcc?atc?gac?cca?cac?tcc?cct?gca?gaa 1603

Gln?Met?Ala?Val?Gln?Tyr?Leu?Ala?Ile?Asp?Pro?His?Ser?Pro?Ala?Glu

490 495 500

ttc?cgc?tgc?aat?gtc?atc?gcc?gga?aac?gtc?gct?gaa?ttc?tac?gaa?gca 1651

Phe?Arg?Cys?Asn?Val?Ile?Ala?Gly?Asn?Val?Ala?Glu?Phe?Tyr?Glu?Ala

505 510 515

ttc?gac?gtc?ccc?gaa?gat?gca?cct?gtg?tac?atc?aag?cca?gaa?gag?cgc 1699

Phe?Asp?Val?Pro?Glu?Asp?Ala?Pro?Val?Tyr?Ile?Lys?Pro?Glu?Glu?Arg

520 525 530

cta?gct?atc?tgg?tagttgttag?ttggtattga?aaa 1734

Leu?Ala?Ile?Trp

535

<210>46

<211>537

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>46

Val?Glu?Lys?Asp?Ser?Ser?Ser?Asn?Glu?Ser?Val?Ala?Tyr?Val?Ile?Gln

1 5 10 15

Ser?Gly?Leu?Gly?Leu?Pro?Asp?Glu?Ala?Tyr?Tyr?Arg?Glu?Glu?Ala?His

20 25 30

Ala?Glu?Thr?Leu?Ala?Ala?Tyr?Lys?Glu?His?Val?Glu?Arg?Met?Leu?Gly

35 40 45

Tyr?Leu?Asp?Asn?Ser?Arg?Leu?Phe?Gly?Leu?Ser?Ala?Ala?Ser?Ala?Ala

50 55 60

Ala?Arg?Ile?Val?Ala?Leu?Glu?Thr?Glu?Ile?Ala?Ala?Gly?His?Trp?Asp

65 70 75 80

Val?Val?Lys?Thr?Arg?Asp?Ala?Val?Ala?Thr?Tyr?Asn?Pro?Thr?Glu?Leu

85 90 95

Gly?Ala?Leu?Pro?Pro?Lys?Val?Arg?Thr?Leu?Leu?Ser?Ser?Ala?Gly?Leu

100 105 110

Pro?Asp?Gln?Arg?Leu?Val?Ser?Met?Met?Pro?Ser?Tyr?Leu?Asp?His?Leu

115 120 125

Asn?Gly?Leu?Leu?Val?Asp?Asp?Arg?Leu?Pro?Asp?Trp?Gln?Leu?Trp?Ala

130 135 140

Thr?Trp?His?Ile?Leu?Arg?Ser?Arg?Ala?Gly?Leu?Leu?Thr?Glu?Glu?Ile

145 150 155 160

Ser?Gln?Ala?Asn?Phe?Asp?Phe?Tyr?Gly?Thr?Lys?Leu?Ser?Gly?Ala?Thr

165 170 175

Glu?Gln?Lys?Asp?Arg?Trp?Lys?Arg?Ala?Val?Gly?Leu?Ala?Glu?Arg?Met

180 185 190

Val?Gly?Glu?Glu?Ile?Gly?Gln?Arg?Phe?Val?Glu?Arg?His?Phe?Pro?Ala

195 200 205

Ser?Ser?Lys?Glu?His?Met?Leu?Glu?Leu?Val?Asp?Tyr?Leu?Val?Ala?Ala

210 215 220

Tyr?Arg?Asp?Arg?Ile?Ser?Asn?Leu?Glu?Trp?Met?Thr?Pro?Ala?Thr?Arg

225 230 235 240

Glu?Arg?Ala?Leu?Glu?Lys?Leu?Gly?Lys?Phe?Asn?Ala?Lys?Ile?Gly?Tyr

245 250 255

Pro?Asp?Lys?Trp?Arg?Ser?Tyr?Glu?Gly?Leu?Glu?Phe?Gly?Ser?Asp?Leu

260 265 270

Val?Asp?Asn?Ser?Arg?Lys?Gly?Ser?Ala?Phe?Leu?His?Asp?Tyr?Glu?Leu

275 280 285

Gly?Lys?Ile?Gly?Lys?Pro?Ala?Asp?Arg?Asp?Glu?Trp?Val?Thr?Thr?Pro

290 295 300

Gln?Thr?Val?Asn?Ala?Phe?Tyr?Asn?Pro?Val?Val?Asn?Asp?Ile?Thr?Phe

305 310 315 320

Pro?Ala?Ala?Ile?Leu?Arg?Ala?Pro?Phe?Phe?Asp?Pro?Glu?Ala?Glu?Ala

325 330 335

Ala?Glu?Asn?Phe?Gly?Ala?Ile?Gly?Ala?Val?Ile?Gly?His?Glu?Ile?Gly

340 345 350

His?Gly?Phe?Asp?Asp?Gln?Gly?Ser?Gln?Tyr?Asp?Gly?Asp?Gly?Asn?Leu

355 360 365

Asn?Ser?Trp?Trp?Thr?Asp?Glu?Asp?Arg?Ser?Ala?Phe?Glu?Gln?Leu?Thr

370 375 380

Ser?Arg?Leu?Val?Thr?Gln?Phe?Ser?Gly?Leu?Val?Pro?Ala?Val?Leu?Thr

385 390 395 400

Ser?Glu?Gly?Ile?Asp?Thr?Asp?Gly?Val?Asn?Gly?Glu?Phe?Thr?Leu?Gly

405 410 415

Glu?Asn?Ile?Gly?Asp?Leu?Gly?Gly?Leu?Gly?Ile?Ala?Val?Val?Ala?Tyr

420 425 430

Glu?Lys?Tyr?Leu?Ala?Asp?Arg?Gly?Gln?Thr?Phe?Glu?Thr?Ser?Pro?Val

435 440 445

Gln?Lys?Phe?Glu?Ala?Glu?Gly?Ala?Glu?Glu?Gly?Leu?Ala?Glu?Gln?Glu

450 455 460

Phe?Asn?Gly?Leu?Gln?Arg?Leu?Phe?Leu?Ser?Trp?Ala?Arg?Val?Trp?Arg

465 470 475 480

Thr?Lys?Ile?Arg?Pro?Gln?Met?Ala?Val?Gln?Tyr?Leu?Ala?Ile?Asp?Pro

485 490 495

His?Ser?Pro?Ala?Glu?Phe?Arg?Cys?Asn?Val?Ile?Ala?Gly?Asn?Val?Ala

500 505 510

Glu?Phe?Tyr?Glu?Ala?Phe?Asp?Val?Pro?Glu?Asp?Ala?Pro?Val?Tyr?Ile

515 520 525

Lys?Pro?Glu?Glu?Arg?Leu?Ala?Ile?Trp

530 535

<210>47

<211>426

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(403)

<223>FRXA0l869

<400>47

tgacaggcta?ccttctgggg?tggacatgat?ccccaacgct?caacccactt?gtggcaccaa?60

ccacaaaccc?tgtggcggta?aatcccctag?agtaggccac?atg?aag?gat?ctt?tat 115

Met?Lys?Asp?Leu?Tyr

1 5

cgc?ttt?gtc?aat?ggc?ctg?tgg?ctt?gac?acc?cac?atc?att?ccc?gac?gat 163

Arg?Phe?Val?Asn?Gly?Leu?Trp?Leu?Asp?Thr?His?Ile?Ile?Pro?Asp?Asp

10 15 20

cgc?gcg?gtg?gac?ggc?acg?ttc?cac?aag?ctg?cgc?gat?gat?gct?gaa?gaa 211

Arg?Ala?Val?Asp?Gly?Thr?Phe?His?Lys?Leu?Arg?Asp?Asp?Ala?Glu?Glu

25 30 35

gac?gtc?cat?gag?atc?gtc?aag?gaa?gac?act?gga?cgc?gca?ggc?aca?ctt 259

Asp?Val?His?Glu?Ile?Val?Lys?Glu?Asp?Thr?Gly?Arg?Ala?Gly?Thr?Leu

40 45 50

tat?gcc?tca?ttt?atg?gat?act?gac?gcc?atc?aac?gct?gct?ggt?gtt?gca 307

Tyr?Ala?Ser?Phe?Met?Asp?Thr?Asp?Ala?Ile?Asn?Ala?Ala?Gly?Val?Ala

55 60 65

ccg?ctc?gat?gcg?gat?ctg?aac?agg?ctg?tct?gtt?gct?aac?tca?tcg?ttt 355

Pro?Leu?Asp?Ala?Asp?Leu?Asn?Arg?Leu?Ser?Val?Ala?Asn?Ser?Ser?Phe

70 75 80 85

tcg?cag?ctg?ctc?tcg?gcg?aac?tgg?acc?gtg?aag?gcg?ttg?gcg?cgc?cag 403

Ser?Gln?Leu?Leu?Ser?Ala?Asn?Trp?Thr?Val?Lys?Ala?Leu?Ala?Arg?Gln

90 95 100

taggtttctg?ggtggagaag?gat 426

<210>48

<211>101

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>48

Met?Lys?Asp?Leu?Tyr?Arg?Phe?Val?Asn?Gly?Leu?Trp?Leu?Asp?Thr?His

1 5 10 15

Ile?Ile?Pro?Asp?Asp?Arg?Ala?Val?Asp?Gly?Thr?Phe?His?Lys?Leu?Arg

20 25 30

Asp?Asp?Ala?Glu?Glu?Asp?Val?His?Glu?Ile?Val?Lys?Glu?Asp?Thr?Gly

35 40 45

Arg?Ala?Gly?Thr?Leu?Tyr?Ala?Ser?Phe?Met?Asp?Thr?Asp?Ala?Ile?Asn

50 55 60

Ala?Ala?Gly?Val?Ala?Pro?Leu?Asp?Ala?Asp?Leu?Asn?Arg?Leu?Ser?Val

65 70 75 80

Ala?Asn?Ser?Ser?Phe?Ser?Gln?Leu?Leu?Ser?Ala?Asn?Trp?Thr?Val?Lys

85 90 95

Ala?Leu?Ala?Arg?Gln

100

<210>49

<211>2898

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(2875)

<223>RXN03028

<400>49

ctaattccaa?gccgagctga?aaaagtctgg?aagttttgcc?caataagggc?gttaaagtgg?60

gtgaaagcga?atttagaaat?aaagaattaa?ggggagagac?atg?ttc?gag?agg?ttt 115

Met?Phe?Glu?Arg?Phe

1 5

acc?gat?cgt?gca?cgc?cgc?gtg?att?gtg?ctc?gcg?cag?gaa?gag?gcg?cgc 163

Thr?Asp?Arg?Ala?Arg?Arg?Val?Ile?Val?Leu?Ala?Gln?Glu?Glu?Ala?Arg

10 15 20

atg?ctc?aac?cac?aat?tac?atc?ggc?acg?gag?cac?att?ctc?ctc?ggc?ctc 211

Met?Leu?Asn?His?Asn?Tyr?Ile?Gly?Thr?Glu?His?Ile?Leu?Leu?Gly?Leu

25 30 35

att?cac?gag?ggc?gag?ggc?gtt?gca?gcc?aag?gct?ttg?gaa?tcc?atg?gga 259

Ile?His?Glu?Gly?Glu?Gly?Val?Ala?Ala?Lys?Ala?Leu?Glu?Ser?Met?Gly

40 45 50

att?tcc?ctg?gac?gcc?gtc?cgc?cag?gaa?gtc?gaa?gag?att?atc?ggc?cag 307

Ile?Ser?Leu?Asp?Ala?Val?Arg?Gln?Glu?Val?Glu?Glu?Ile?Ile?Gly?Gln

55 60 65

ggc?tcc?cag?ccc?acc?acc?ggc?cac?att?cct?ttt?act?cca?cgt?gcc?aag 355

Gly?Ser?Gln?Pro?Thr?Thr?Gly?His?Ile?Pro?Phe?Thr?Pro?Arg?Ala?Lys

70 75 80 85

aag?gtc?ctg?gag?ctc?agc?ctc?cgc?gaa?ggc?cta?caa?atg?gga?cac?aag 403

Lys?Val?Leu?Glu?Leu?Ser?Leu?Arg?Glu?Gly?Leu?Gln?Met?Gly?His?Lys

90 95 100

tac?atc?ggt?act?gag?ttc?ctg?ctt?ctc?ggt?ttg?atc?cgt?gag?ggc?gag 451

Tyr?Ile?Gly?Thr?Glu?Phe?Leu?Leu?Leu?Gly?Leu?Ile?Arg?Glu?Gly?Glu

105 110 115

ggc?gtt?gct?gcc?cag?gtc?ctg?gtc?aag?ctt?ggt?gct?gat?ctg?cca?cgc 499

Gly?Val?Ala?Ala?Gln?Val?Leu?Val?Lys?Leu?Gly?Ala?Asp?Leu?Pro?Arg

120 125 130

gtg?cgt?cag?caa?gtt?att?cag?ctt?ctc?tcc?ggc?tac?gaa?ggt?ggc?cag 547

Val?Arg?Gln?Gln?Val?Ile?Gln?Leu?Leu?Ser?Gly?Tyr?Glu?Gly?Gly?Gln

135 140 145

ggc?gga?tcc?cca?gag?ggc?ggc?cag?ggc?gcc?cct?act?ggc?ggt?gac?gct 595

Gly?Gly?Ser?Pro?Glu?Gly?Gly?Gln?Gly?Ala?Pro?Thr?Gly?Gly?Asp?Ala

150 155 160 165

gtt?ggt?gca?gga?gct?gct?cct?ggc?ggt?cgt?cca?tct?tcg?ggc?agc?cca 643

Val?Gly?Ala?Gly?Ala?Ala?Pro?Gly?Gly?Arg?Pro?Ser?Ser?Gly?Ser?Pro

170 175 180

ggc?gag?cgt?tct?acc?tct?ttg?gtc?ctt?gac?cag?ttc?ggc?cgc?aac?ctc 691

Gly?Glu?Arg?Ser?Thr?Ser?Leu?Val?Leu?Asp?Gln?Phe?Gly?Arg?Asn?Leu

185 190 195

acc?cag?gct?gca?aag?gac?ggc?aag?ctg?gat?cca?gtt?gtt?ggt?cgc?gat 739

Thr?Gln?Ala?Ala?Lys?Asp?Gly?Lys?Leu?Asp?Pro?Val?Val?Gly?Arg?Asp

200 205 210

aag?gaa?atc?gag?cgc?atc?atg?cag?gtg?ctc?tcc?cgt?cgt?acc?aag?aac 787

Lys?Glu?Ile?Glu?Arg?Ile?Met?Gln?Val?Leu?Ser?Arg?Arg?Thr?Lys?Asn

215 220 225

aac?cca?gtt?ctt?att?ggt?gag?cca?ggt?gtt?ggt?aag?acc?gca?gtt?gtt 835

Asn?Pro?Val?Leu?Ile?Gly?Glu?Pro?Gly?Val?Gly?Lys?Thr?Ala?Val?Val

230 235 240 245

gaa?ggt?ctt?gca?cta?gac?att?gtt?aac?ggc?aag?gtt?cca?gag?acc?ctc 883

Glu?Gly?Leu?Ala?Leu?Asp?Ile?Val?Asn?Gly?Lys?Val?Pro?Glu?Thr?Leu

250 255 260

aag?gac?aag?cag?gtt?tac?tcc?ctt?gac?tta?ggt?tcc?ctg?gtt?gca?ggt 931

Lys?Asp?Lys?Gln?Val?Tyr?Ser?Leu?Asp?Leu?Gly?Ser?Leu?Val?Ala?Gly

265 270 275

tcc?cgt?tac?cgc?ggt?gac?ttc?gaa?gag?cga?ctg?aag?aag?gtc?ctc?aag 979

Ser?Arg?Tyr?Arg?Gly?Asp?Phe?Glu?Glu?Arg?Leu?Lys?Lys?Val?Leu?Lys

280 285 290

gag?att?aac?cag?cgc?ggc?gac?atc?atc?ctg?ttt?atc?gat?gag?atc?cac 1027

Glu?Ile?Asn?Gln?Arg?Gly?Asp?Ile?Ile?Leu?Phe?Ile?Asp?Glu?Ile?His

295 300 305

acc?ctc?gtg?ggt?gca?ggt?gca?gca?gaa?ggc?gca?atc?gac?gct?gcc?tcc 1075

Thr?Leu?Val?Gly?Ala?Gly?Ala?Ala?Glu?Gly?Ala?Ile?Asp?Ala?Ala?Ser

310 315 320 325

ctg?ctt?aag?cca?aag?ctt?gcc?cgc?ggt?gaa?ctg?cag?acc?att?ggt?gca 1123

Leu?Leu?Lys?Pro?Lys?Leu?Ala?Arg?Gly?Glu?Leu?Gln?Thr?Ile?Gly?Ala

330 335 340

acc?acc?ctg?gat?gag?tac?cgt?aag?cac?att?gaa?aag?gac?gca?gct?ctt 1171

Thr?Thr?Leu?Asp?Glu?Tyr?Arg?Lys?His?Ile?Glu?Lys?Asp?Ala?Ala?Leu

345 350 355

gag?cgt?cgt?ttc?cag?cca?gtg?cag?gtt?cca?gag?cct?tcg?gtt?gat?ctc 1219

Glu?Arg?Arg?Phe?Gln?Pro?Val?Gln?Val?Pro?Glu?Pro?Ser?Val?Asp?Leu

360 365 370

acc?gtt?gag?atc?ttg?aag?ggt?ctg?cgc?gac?cgc?tac?gaa?gct?cac?cac 1267

Thr?Val?Glu?Ile?Leu?Lys?Gly?Leu?Arg?Asp?Arg?Tyr?Glu?Ala?His?His

375 380 385

cgc?gta?tcc?atc?acc?gat?ggt?gct?ctt?act?gca?gca?gct?cag?ctt?gct 1315

Arg?Val?Ser?Ile?Thr?Asp?Gly?Ala?Leu?Thr?Ala?Ala?Ala?Gln?Leu?Ala

390 395 400 405

gat?cgc?tac?atc?aac?gac?cgc?ttc?ttg?cca?gat?aag?gcc?gtt?gac?ctc 1363

Asp?Arg?Tyr?Ile?Asn?Asp?Arg?Phe?Leu?Pro?Asp?Lys?Ala?Val?Asp?Leu

410 415 420

atc?gat?gag?gct?ggc?gcc?cgc?atg?cgc?atc?aag?cgc?atg?acc?gca?cct 1411

Ile?Asp?Glu?Ala?Gly?Ala?Arg?Met?Arg?Ile?Lys?Arg?Met?Thr?Ala?Pro

425 430 435

tcc?tcc?ctc?cgc?gag?gtt?gat?gag?cgt?atc?gct?gat?gtt?cgc?cgt?gag 1459

Ser?Ser?Leu?Arg?Glu?Val?Asp?Glu?Arg?Ile?Ala?Asp?Val?Arg?Arg?Glu

440 445 450

aag?gaa?gca?gcg?atc?gat?gct?cag?gac?ttt?gag?aag?gca?gca?ggt?ctt 1507

Lys?Glu?Ala?Ala?Ile?Asp?Ala?Gln?Asp?Phe?Glu?Lys?Ala?Ala?Gly?Leu

455 460 465

cgc?gat?aag?gag?cgc?aag?ctc?ggc?gaa?gag?cgt?tca?gag?aag?gaa?aag 1555

Arg?Asp?Lys?Glu?Arg?Lys?Leu?Gly?Glu?Glu?Arg?Ser?Glu?Lys?Glu?Lys

470 475 480 485

cag?tgg?cgc?tcc?ggc?gac?ctc?gag?gac?atc?gct?gag?gtt?ggc?gaa?gag 1603

Gln?Trp?Arg?Ser?Gly?Asp?Leu?Glu?Asp?Ile?Ala?Glu?Val?Gly?Glu?Glu

490 495 500

cag?atc?gca?gaa?gta?ctg?gcc?aac?tgg?act?ggt?att?cct?gtc?ttc?aag 1651

Gln?Ile?Ala?Glu?Val?Leu?Ala?Asn?Trp?Thr?Gly?Ile?Pro?Val?Phe?Lys

505 510 515

ctc?acc?gaa?gct?gaa?tct?tca?cgc?ctg?ctc?aac?atg?gaa?gaa?gag?ttg 1699

Leu?Thr?Glu?Ala?Glu?Ser?Ser?Arg?Leu?Leu?Asn?Met?Glu?Glu?Glu?Leu

520 525 530

cac?aag?cgc?atc?atc?gga?cag?gat?gaa?gct?gtc?aag?gct?gtc?tcc?cgt 1747

His?Lys?Arg?Ile?Ile?Gly?Gln?Asp?Glu?Ala?Val?Lys?Ala?Val?Ser?Arg

535 540 545

gcg?atc?cgt?cgt?acc?cgt?gca?ggt?ctg?aag?gat?cct?aag?cgt?cct?tcc 1795

Ala?Ile?Arg?Arg?Thr?Arg?Ala?Gly?Leu?Lys?Asp?Pro?Lys?Arg?Pro?Ser

550 555 560 565

ggc?tcc?ttc?atc?ttc?gct?ggt?cca?tcc?ggc?gtt?ggt?aag?acc?gag?ctg 1843

Gly?Ser?Phe?Ile?Phe?Ala?Gly?Pro?Ser?Gly?Val?Gly?Lys?Thr?Glu?Leu

570 575 580

tcc?aag?gct?ctc?gca?gga?ttc?ctc?ttc?ggt?gac?gat?gat?tcc?ctc?atc 1891

Ser?Lys?Ala?Leu?Ala?Gly?Phe?Leu?Phe?Gly?Asp?Asp?Asp?Ser?Leu?Ile

585 590 595

caa?atc?gac?atg?ggt?gag?ttc?cac?gac?cgc?ttc?acc?gcg?tcc?cga?ctt 1939

Gln?Ile?Asp?Met?Gly?Glu?Phe?His?Asp?Arg?Phe?Thr?Ala?Ser?Arg?Leu

600 605 610

ttc?ggt?gcc?cct?ccg?gga?tac?gtt?ggc?tac?gaa?gaa?ggt?ggc?cag?ctg 1987

Phe?Gly?Ala?Pro?Pro?Gly?Tyr?Val?Gly?Tyr?Glu?Glu?Gly?Gly?Gln?Leu

615 620 625

acc?gag?aag?gtt?cgc?cgt?aag?cca?ttc?tcc?gtt?gtg?ctt?ttc?gac?gaa 2035

Thr?Glu?Lys?Val?Arg?Arg?Lys?Pro?Phe?Ser?Val?Val?Leu?Phe?Asp?Glu

630 635 640 645

atc?gag?aag?gcc?cac?aag?gag?atc?tac?aac?acc?ttg?ctg?cag?gtg?ttg 2083

Ile?Glu?Lys?Ala?His?Lys?Glu?Ile?Tyr?Asn?Thr?Leu?Leu?Gln?Val?Leu

650 655 660

gaa?gat?ggt?cgc?ctt?acc?gat?ggt?cag?gga?cgc?atc?gtg?gac?ttc?aag 2131

Glu?Asp?Gly?Arg?Leu?Thr?Asp?Gly?Gln?Gly?Arg?Ile?Val?Asp?Phe?Lys

665 670 675

aac?acc?gtc?ctg?atc?ttc?acc?tcc?aac?ctg?ggc?acc?gct?gac?atc?tcc 2179

Asn?Thr?Val?Leu?Ile?Phe?Thr?Ser?Asn?Leu?Gly?Thr?Ala?Asp?Ile?Ser

680 685 690

aag?gct?gtt?ggc?ctg?ggc?ttc?tcc?gga?tcc?tcc?gag?act?gac?agc?gat 2227

Lys?Ala?Val?Gly?Leu?Gly?Phe?Ser?Gly?Ser?Ser?Glu?Thr?Asp?Ser?Asp

695 700 705

gct?cag?tac?gac?cgc?atg?aag?aac?aag?gtc?cac?gac?gag?ctg?aag?aag 2275

Ala?Gln?Tyr?Asp?Arg?Met?Lys?Asn?Lys?Val?His?Asp?Glu?Leu?Lys?Lys

710 715 720 725

cac?ttc?cgc?cct?gag?ttc?ctg?aac?cgt?att?gat?gag?atc?gtg?gtc?ttc 2323

His?Phe?Arg?Pro?Glu?Phe?Leu?Asn?Arg?Ile?Asp?Glu?Ile?Val?Val?Phe

730 735 740

cac?cag?ctc?acc?aag?gat?cag?atc?gtt?cag?atg?gtc?gac?ctt?ctt?atc 2371

His?Gln?Leu?Thr?Lys?Asp?Gln?Ile?Val?Gln?Met?Val?Asp?Leu?Leu?Ile

745 750 755

ggt?cgc?gtt?tcc?aac?gca?ctg?gct?gag?aag?gac?atg?agc?atc?gaa?ctg 2419

Gly?Arg?Val?Ser?Asn?Ala?Leu?Ala?Glu?Lys?Asp?Met?Ser?Ile?Glu?Leu

760 765 770

act?gag?aag?gcc?aag?gac?ctc?ctg?gct?aac?cga?ggc?ttc?gat?cca?gtt 2467

Thr?Glu?Lys?Ala?Lys?Asp?Leu?Leu?Ala?Asn?Arg?Gly?Phe?Asp?Pro?Val

775 780 785

ctg?ggt?gca?cga?cca?ttg?cgt?cgc?acc?atc?cag?cgc?gaa?att?gaa?gac 2515

Leu?Gly?Ala?Arg?Pro?Leu?Arg?Arg?Thr?Ile?Gln?Arg?Glu?Ile?Glu?Asp

790 795 800 805

cag?atg?tcc?gag?aag?atc?ctc?ttc?ggt?gaa?atc?ggc?gca?ggc?gag?atc 2563

Gln?Met?Ser?Glu?Lys?Ile?Leu?Phe?Gly?Glu?Ile?Gly?Ala?Gly?Glu?Ile

810 815 820

gtc?acc?gtt?gac?gtc?gaa?ggc?tgg?gac?ggc?gag?tcc?aag?gac?acc?gac 2611

Val?Thr?Val?Asp?Val?Glu?Gly?Trp?Asp?Gly?Glu?Ser?Lys?Asp?Thr?Asp

825 830 835

cgt?gcg?aag?ttc?acc?ttc?aca?cca?cgt?cca?aag?cca?atg?cca?gaa?ggt 2659

Arg?Ala?Lys?Phe?Thr?Phe?Thr?Pro?Arg?Pro?Lys?Pro?Met?Pro?Glu?Gly

840 845 850

aag?ttc?tct?gag?atc?tct?gtc?gag?gct?gcg?gaa?gca?att?caa?gat?gta 2707

Lys?Phe?Ser?Glu?Ile?Ser?Val?Glu?Ala?Ala?Glu?Ala?Ile?Gln?Asp?Val

855 860 865

gat?tct?gca?gct?gac?ggc?gat?gtc?cca?gaa?acc?gat?tca?ctt?tcc?gac 2755

Asp?Ser?Ala?Ala?Asp?Gly?Asp?Val?Pro?Glu?Thr?Asp?Ser?Leu?Ser?Asp

870 875 880 885

att?gac?ctt?gaa?acc?ctt?gaa?aag?ttt?gag?gaa?gat?gta?gaa?aac?ggc 2803

Ile?Asp?Leu?Glu?Thr?Leu?Glu?Lys?Phe?Glu?Glu?Asp?Val?Glu?Asn?Gly

890 895 900

acc?gac?att?gat?cag?gtg?tcc?ggt?gac?tac?tac?ggc?acc?gat?gat?cag 2851

Thr?Asp?Ile?Asp?Gln?Val?Ser?Gly?Asp?Tyr?Tyr?Gly?Thr?Asp?Asp?Gln

905 910 915

gga?ggc?act?gct?cca?agc?aag?gag?tagcaacctt?ttgaaaaagg?gcc 2898

Gly?Gly?Thr?Ala?Pro?Ser?Lys?Glu

920 925

<210>50

<211>925

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>50

Met?Phe?Glu?Arg?Phe?Thr?Asp?Arg?Ala?Arg?Arg?Val?Ile?Val?Leu?Ala

1 5 10 15

Gln?Glu?Glu?Ala?Arg?Met?Leu?Asn?His?Asn?Tyr?Ile?Gly?Thr?Glu?His

20 25 30

Ile?Leu?Leu?Gly?Leu?Ile?His?Glu?Gly?Glu?Gly?Val?Ala?Ala?Lys?Ala

35 40 45

Leu?Glu?Ser?Met?Gly?Ile?Ser?Leu?Asp?Ala?Val?Arg?Gln?Glu?Val?Glu

50 55 60

Glu?Ile?Ile?Gly?Gln?Gly?Ser?Gln?Pro?Thr?Thr?Gly?His?Ile?Pro?Phe

65 70 75 80

Thr?Pro?Arg?Ala?Lys?Lys?Val?Leu?Glu?Leu?Ser?Leu?Arg?Glu?Gly?Leu

85 90 95

Gln?Met?Gly?His?Lys?Tyr?Ile?Gly?Thr?Glu?Phe?Leu?Leu?Leu?Gly?Leu

100 105 110

Ile?Arg?Glu?Gly?Glu?Gly?Val?Ala?Ala?Gln?Val?Leu?Val?Lys?Leu?Gly

115 120 125

Ala?Asp?Leu?Pro?Arg?Val?Arg?Gln?Gln?Val?Ile?Gln?Leu?Leu?Ser?Gly

130 135 140

Tyr?Glu?Gly?Gly?Gln?Gly?Gly?Ser?Pro?Glu?Gly?Gly?Gln?Gly?Ala?Pro

145 150 155 160

Thr?Gly?Gly?Asp?Ala?Val?Gly?Ala?Gly?Ala?Ala?Pro?Gly?Gly?Arg?Pro

165 170 175

Ser?Ser?Gly?Ser?Pro?Gly?Glu?Arg?Ser?Thr?Ser?Leu?Val?Leu?Asp?Gln

180 185 190

Phe?Gly?Arg?Asn?Leu?Thr?Gln?Ala?Ala?Lys?Asp?Gly?Lys?Leu?Asp?Pro

195 200 205

Val?Val?Gly?Arg?Asp?Lys?Glu?Ile?Glu?Arg?Ile?Met?Gln?Val?Leu?Ser

210 215 220

Arg?Arg?Thr?Lys?Asn?Asn?Pro?Val?Leu?Ile?Gly?Glu?Pro?Gly?Val?Gly

225 230 235 240

Lys?Thr?Ala?Val?Val?Glu?Gly?Leu?Ala?Leu?Asp?Ile?Val?Asn?Gly?Lys

245 250 255

Val?Pro?Glu?Thr?Leu?Lys?Asp?Lys?Gln?Val?Tyr?Ser?Leu?Asp?Leu?Gly

260 265 270

Ser?Leu?Val?Ala?Gly?Ser?Arg?Tyr?Arg?Gly?Asp?Phe?Glu?Glu?Arg?Leu

275 280 285

Lys?Lys?Val?Leu?Lys?Glu?Ile?Asn?Gln?Arg?Gly?Asp?Ile?Ile?Leu?Phe

290 295 300

Ile?Asp?Glu?Ile?His?Thr?Leu?Val?Gly?Ala?Gly?Ala?Ala?Glu?Gly?Ala

305 310 315 320

Ile?Asp?Ala?Ala?Ser?Leu?Leu?Lys?Pro?Lys?Leu?Ala?Arg?Gly?Glu?Leu

325 330 335

Gln?Thr?Ile?Gly?Ala?Thr?Thr?Leu?Asp?Glu?Tyr?Arg?Lys?His?Ile?Glu

340 345 350

Lys?Asp?Ala?Ala?Leu?Glu?Arg?Arg?Phe?Gln?Pro?Val?Gln?Val?Pro?Glu

355 360 365

Pro?Ser?Val?Asp?Leu?Thr?Val?Glu?Ile?Leu?Lys?Gly?Leu?Arg?Asp?Arg

370 375 380

Tyr?Glu?Ala?His?His?Arg?Val?Ser?Ile?Thr?Asp?Gly?Ala?Leu?Thr?Ala

385 390 395 400

Ala?Ala?Gln?Leu?Ala?Asp?Arg?Tyr?Ile?Asn?Asp?Arg?Phe?Leu?Pro?Asp

405 410 415

Lys?Ala?Val?Asp?Leu?Ile?Asp?Glu?Ala?Gly?Ala?Arg?Met?Arg?Ile?Lys

420 425 430

Arg?Met?Thr?Ala?Pro?Ser?Ser?Leu?Arg?Glu?Val?Asp?Glu?Arg?Ile?Ala

435 440 445

Asp?Val?Arg?Arg?Glu?Lys?Glu?Ala?Ala?Ile?Asp?Ala?Gln?Asp?Phe?Glu

450 455 460

Lys?Ala?Ala?Gly?Leu?Arg?Asp?Lys?Glu?Arg?Lys?Leu?Gly?Glu?Glu?Arg

465 470 475 480

Ser?Glu?Lys?Glu?Lys?Gln?Trp?Arg?Ser?Gly?Asp?Leu?Glu?Asp?Ile?Ala

485 490 495

Glu?Val?Gly?Glu?Glu?Gln?Ile?Ala?Glu?Val?Leu?Ala?Asn?Trp?Thr?Gly

500 505 510

Ile?Pro?Val?Phe?Lys?Leu?Thr?Glu?Ala?Glu?Ser?Ser?Arg?Leu?Leu?ASn

515 520 525

Met?Glu?Glu?Glu?Leu?His?Lys?Arg?Ile?Ile?Gly?Gln?Asp?Glu?Ala?Val

530 535 540

Lys?Ala?Val?Ser?Arg?Ala?Ile?Arg?Arg?Thr?Arg?Ala?Gly?Leu?Lys?Asp

545 550 555 560

Pro?Lys?Arg?Pro?Ser?Gly?Ser?Phe?Ile?Phe?Ala?Gly?Pro?Ser?Gly?Val

565 570 575

Gly?Lys?Thr?Glu?Leu?Ser?Lys?Ala?Leu?Ala?Gly?Phe?Leu?Phe?Gly?Asp

580 585 590

Asp?Asp?Ser?Leu?Ile?Gln?Ile?Asp?Met?Gly?Glu?Phe?His?Asp?Arg?Phe

595 600 605

Thr?Ala?Ser?Arg?Leu?Phe?Gly?Ala?Pro?Pro?Gly?Tyr?Val?Gly?Tyr?Glu

610 615 620

Glu?Gly?Gly?Gln?Leu?Thr?Glu?Lys?Val?Arg?Arg?Lys?Pro?Phe?Ser?Val

625 630 635 640

Val?Leu?Phe?Asp?Glu?Ile?Glu?Lys?Ala?His?Lys?Glu?Ile?Tyr?Asn?Thr

645 650 655

Leu?Leu?Gln?Val?Leu?Glu?Asp?Gly?Arg?Leu?Thr?Asp?Gly?Gln?Gly?Arg

660 665 670

Ile?Val?Asp?Phe?Lys?Asn?Thr?Val?Leu?Ile?Phe?Thr?Ser?Asn?Leu?Gly

675 680 685

Thr?Ala?Asp?Ile?Ser?Lys?Ala?Val?Gly?Leu?Gly?Phe?Ser?Gly?Ser?Ser

690 695 700

Glu?Thr?Asp?Ser?Asp?Ala?Gln?Tyr?Asp?Arg?Met?Lys?Asn?Lys?Val?His

705 710 715 720

Asp?Glu?Leu?Lys?Lys?His?Phe?Arg?Pro?GIu?Phe?Leu?Asn?Arg?Ile?Asp

725 730 735

Glu?Ile?Val?Val?Phe?His?Gln?Leu?Thr?Lys?Asp?Gln?Ile?Val?Gln?Met

740 745 750

Val?Asp?Leu?Leu?Ile?Gly?Arg?Val?Ser?Asn?Ala?Leu?Ala?Glu?Lys?Asp

755 760 765

Met?Ser?Ile?Glu?Leu?Thr?Glu?Lys?Ala?Lys?Asp?Leu?Leu?Ala?Asn?Arg

770 775 780

Gly?Phe?Asp?Pro?Val?Leu?Gly?Ala?Arg?Pro?Leu?Arg?Arg?Thr?Ile?Gln

785 790 795 800

Arg?Glu?Ile?Glu?Asp?Gln?Met?Ser?Glu?Lys?Ile?Leu?Phe?Gly?Glu?Ile

805 810 815

Gly?Ala?Gly?Glu?Ile?Val?Thr?Val?Asp?Val?Glu?Gly?Trp?Asp?Gly?Glu

820 825 830

Ser?Lys?Asp?Thr?Asp?Arg?Ala?Lys?Phe?Thr?Phe?Thr?Pro?Arg?Pro?Lys

835 840 845

Pro?Met?Pro?Glu?Gly?Lys?Phe?Ser?Glu?Ile?Ser?Val?Glu?Ala?Ala?Glu

850 855 860

Ala?Ile?Gln?Asp?Val?Asp?Ser?Ala?Ala?Asp?Gly?Asp?Val?Pro?Glu?Thr

865 870 875 880

Asp?Ser?Leu?Ser?Asp?Ile?Asp?Leu?Glu?Thr?Leu?Glu?Lys?Phe?Glu?Glu

885 890 895

Asp?Val?Glu?Asn?Gly?Thr?Asp?Ile?Asp?Gln?Val?Ser?Gly?Asp?Tyr?Tyr

900 905 910

Gly?Thr?Asp?Asp?Gln?Gly?Gly?Thr?Ala?Pro?Ser?Lys?Glu

915 920 925

<210>51

<211>1104

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1081)

<223>FRXA02470

<400>51

ctaattccaa?gccgagctga?aaaagtctgg?aagttttgcc?caataagggc?gttaaagtgg?60

gtgaaagcga?atttagaaat?aaagaattaa?ggggagagac?atg?ttc?gag?agg?ttt 115

Met?Phe?Glu?Arg?Phe

1 5

acc?gat?cgt?gca?cgc?cgc?gtg?att?gtg?ctc?gcg?cag?gaa?gag?gcg?cgc 163

Thr?Asp?Arg?Ala?Arg?Arg?Val?Ile?Val?Leu?Ala?Gln?Glu?Glu?Ala?Arg

10 15 20

atg?ctc?aac?cac?aat?tac?atc?ggc?acg?gag?cac?att?ctc?ctc?ggc?ctc 211

Met?Leu?Asn?His?Asn?Tyr?Ile?Gly?Thr?Glu?His?Ile?Leu?Leu?Gly?Leu

25 30 35

att?cac?gag?ggc?gag?ggc?gtt?gca?gcc?aag?gct?ttg?gaa?tcc?atg?gga 259

Ile?His?Glu?Gly?Glu?Gly?Val?Ala?Ala?Lys?Ala?Leu?Glu?Ser?Met?Gly

40 45 50

att?tcc?ctg?gac?gcc?gtc?cgc?cag?gaa?gtc?gaa?gag?att?atc?ggc?cag 307

Ile?Ser?Leu?Asp?Ala?Val?Arg?Gln?Glu?Val?Glu?Glu?Ile?Ile?Gly?Gln

55 60 65

ggc?tcc?cag?ccc?acc?acc?ggc?cac?att?cct?ttt?act?cca?cgt?gcc?aag 355

Gly?Ser?Gln?Pro?Thr?Thr?Gly?His?Ile?Pro?Phe?Thr?Pro?Arg?Ala?Lys

70 75 80 85

aag?gtc?ctg?gag?ctc?agc?ctc?cgc?gaa?ggc?cta?caa?atg?gga?cac?aag 403

Lys?Val?Leu?Glu?Leu?Ser?Leu?Arg?Glu?Gly?Leu?Gln?Met?Gly?His?Lys

90 95 100

tac?atc?ggt?act?gag?ttc?ctg?ctt?ctc?ggt?ttg?atc?cgt?gag?ggc?gag 451

Tyr?Ile?Gly?Thr?Glu?Phe?Leu?Leu?Leu?Gly?Leu?Ile?Arg?Glu?Gly?Glu

105 110 115

ggc?gtt?gct?gcc?cag?gtc?ctg?gtc?aag?ctt?ggt?gct?gat?ctg?cca?cgc 499

Gly?Val?Ala?Ala?Gln?Val?Leu?Val?Lys?Leu?Gly?Ala?Asp?Leu?Pro?Arg

120 125 130

gtg?cgt?cag?caa?gtt?att?cag?ctt?ctc?tcc?ggc?tac?gaa?ggt?ggc?cag 547

Val?Arg?Gln?Gln?Val?Ile?Gln?Leu?Leu?Ser?Gly?Tyr?Glu?Gly?Gly?Gln

135 140 145

ggc?gga?tcc?cca?gag?ggc?ggc?cag?ggc?gcc?cct?act?ggc?ggt?gac?gct 595

Gly?Gly?Ser?Pro?Glu?Gly?Gly?Gln?Gly?Ala?Pro?Thr?Gly?Gly?Asp?Ala

150 155 160 165

gtt?ggt?gca?gga?gct?gct?cct?ggc?ggt?cgt?cca?tct?tcg?ggc?agc?cca 643

Val?Gly?Ala?Gly?Ala?Ala?Pro?Gly?Gly?Arg?Pro?Ser?Ser?Gly?Ser?Pro

170 175 180

ggc?gag?cgt?tct?acc?tct?ttg?gtc?ctt?gac?cag?ttc?ggc?cgc?aac?ctc 691

Gly?Glu?Arg?Ser?Thr?Ser?Leu?Val?Leu?Asp?Gln?Phe?Gly?Arg?Asn?Leu

185 190 195

acc?cag?gct?gca?aag?gac?ggc?aag?ctg?gat?cca?gtt?gtt?ggt?cgc?gat 739

Thr?Gln?Ala?Ala?Lys?Asp?Gly?Lys?Leu?Asp?Pro?Val?Val?Gly?Arg?Asp

200 205 210

aag?gaa?atc?gag?cgc?atc?atg?cag?gtg?ctc?tcc?cgt?cgt?acc?aag?aac 787

Lys?Glu?Ile?Glu?Arg?Ile?Met?Gln?Val?Leu?Ser?Arg?Arg?Thr?Lys?Asn

215 220 225

aac?cca?gtt?ctt?att?ggt?gag?cca?ggt?gtt?ggt?aag?acc?gca?gtt?gtt 835

Asn?Pro?Val?Leu?Ile?Gly?Glu?Pro?Gly?Val?Gly?Lys?Thr?Ala?Val?Val

230 235 240 245

gaa?ggt?ctt?gca?cta?gac?att?gtt?aac?ggc?aag?gtt?cca?gag?acc?ctc 883

Glu?Gly?Leu?Ala?Leu?Asp?Ile?Val?Asn?Gly?Lys?Val?Pro?Glu?Thr?Leu

250 255 260

aag?gac?aag?cag?gtt?tac?tcc?ctt?gac?tta?ggt?tcc?ctg?gtt?gca?ggt 931

Lys?Asp?Lys?Gln?Val?Tyr?Ser?Leu?Asp?Leu?Gly?Ser?Leu?Val?Ala?Gly

265 270 275

tcc?cgt?tac?cgc?ggt?gac?ttc?gaa?gag?cga?ctg?aag?aag?gtc?ctc?aag 979

Ser?Arg?Tyr?Arg?Gly?Asp?Phe?Glu?Glu?Arg?Leu?Lys?Lys?Val?Leu?Lys

280 285 290

gag?att?aac?cag?cgc?ggc?gac?atc?atc?ctg?ttt?atc?gat?gag?atc?cac 1027

Glu?Ile?Asn?Gln?Arg?Gly?Asp?Ile?Ile?Leu?Phe?Ile?Asp?Glu?Ile?His

295 300 305

acc?ctc?gtg?ggt?gca?ggt?gca?gca?cga?agg?cgc?aat?cga?cgc?tgc?ctc 1075

Thr?Leu?Val?Gly?Ala?Gly?Ala?Ala?Arg?Arg?Arg?Asn?Arg?Arg?Cys?Leu

310 315 320 325

cct?gct?taagccaaag?cttgcccgcg?gtg 1104

Pro?Ala

<210>52

<211>327

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>52

Met?Phe?Glu?Arg?Phe?Thr?Asp?Arg?Ala?Arg?Arg?Val?Ile?Val?Leu?Ala

1 5 10 15

Gln?Glu?Glu?Ala?Arg?Met?Leu?Asn?His?Asn?Tyr?Ile?Gly?Thr?Glu?His

20 25 30

Ile?Leu?Leu?Gly?Leu?Ile?His?Glu?Gly?Glu?Gly?Val?Ala?Ala?Lys?Ala

35 40 45

Leu?Glu?Ser?Met?Gly?Ile?Ser?Leu?Asp?Ala?Val?Arg?Gln?Glu?Val?Glu

50 55 60

Glu?Ile?Ile?Gly?Gln?Gly?Ser?Gln?Pro?Thr?Thr?Gly?His?Ile?Pro?Phe

65 70 75 80

Thr?Pro?Arg?Ala?Lys?Lys?Val?Leu?Glu?Leu?Ser?Leu?Arg?Glu?Gly?Leu

85 90 95

Gln?Met?Gly?His?Lys?Tyr?Ile?Gly?Thr?Glu?Phe?Leu?Leu?Leu?Gly?Leu

100 105 110

Ile?Arg?Glu?Gly?Glu?Gly?Val?Ala?Ala?Gln?Val?Leu?Val?Lys?Leu?Gly

115 120 125

Ala?Asp?Leu?Pro?Arg?Val?Arg?Gln?Gln?Val?Ile?Gln?Leu?Leu?Ser?Gly

130 135 140

Tyr?Glu?Gly?Gly?Gln?Gly?Gly?Ser?Pro?Glu?Gly?Gly?Gln?Gly?Ala?Pro

145 150 155 160

Thr?Gly?Gly?Asp?Ala?Val?Gly?Ala?Gly?Ala?Ala?Pro?Gly?Gly?Arg?Pro

165 170 175

Ser?Ser?Gly?Ser?Pro?Gly?Glu?Arg?Ser?Thr?Ser?Leu?Val?Leu?Asp?Gln

180 185 190

Phe?Gly?Arg?Asn?Leu?Thr?Gln?Ala?Ala?Lys?Asp?Gly?Lys?Leu?Asp?Pro

195 200 205

Val?Val?Gly?Arg?Asp?Lys?Glu?Ile?Glu?Arg?Ile?Met?Gln?Val?Leu?Ser

210 215 220

Arg?Arg?Thr?Lys?Asn?Asn?Pro?Val?Leu?Ile?Gly?Glu?Pro?Gly?Val?Gly

225 230 235 240

Lys?Thr?Ala?Val?Val?Glu?Gly?Leu?Ala?Leu?Asp?Ile?Val?Asn?Gly?Lys

245 250 255

Val?Pro?Glu?Thr?Leu?Lys?Asp?Lys?Gln?Val?Tyr?Ser?Leu?Asp?Leu?Gly

260 265 270

Ser?Leu?Val?Ala?Gly?Ser?Arg?Tyr?Arg?Gly?Asp?Phe?Glu?Glu?Arg?Leu

275 280 285

Lys?Lys?Val?Leu?Lys?Glu?Ile?Asn?Gln?Arg?Gly?Asp?Ile?Ile?Leu?Phe

290 295 300

Ile?Asp?Glu?Ile?His?Thr?Leu?Val?Gly?Ala?Gly?Ala?Ala?Arg?Arg?Arg

305 310 315 320

Asn?Arg?Arg?Cys?Leu?Pro?Ala

325

<210>53

<211>1956

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1933)

<223>FRXA02471

<400>53

ggtgacttcg?aagagcgact?gaagaaggtc?ctcaaggaga?ttaaccagcg?cggcgacatc?60

atcctgttta?tcgatgagat?ccacaccctc?gtgggtgcag?gtg?cag?cac?gaa?ggc 115

Val?Gln?His?Glu?Gly

1 5

gca?atc?gac?gct?gcc?tcc?ctg?ctt?aag?cca?aag?ctt?gcc?cgc?ggt?gaa 163

Ala?Ile?Asp?Ala?Ala?Ser?Leu?Leu?Lys?Pro?Lys?Leu?Ala?Arg?Gly?Glu

10 15 20

ctg?cag?acc?att?ggt?gca?acc?acc?ctg?gat?gag?tac?cgt?aag?cac?att 211

Leu?Gln?Thr?Ile?Gly?Ala?Thr?Thr?Leu?Asp?Glu?Tyr?Arg?Lys?His?Ile

25 30 35

gaa?aag?gac?gca?gct?ctt?gag?cgt?cgt?ttc?cag?cca?gtg?cag?gtt?cca 259

Glu?Lys?Asp?Ala?Ala?Leu?Glu?Arg?Arg?Phe?Gln?Pro?Val?Gln?Val?Pro

40 45 50

gag?cct?tcg?gtt?gat?ctc?acc?gtt?gag?atc?ttg?aag?ggt?ctg?cgc?gac 307

Glu?Pro?Ser?Val?Asp?Leu?Thr?Val?Glu?Ile?Leu?Lys?Gly?Leu?Arg?Asp

55 60 65

cgc?tac?gaa?gct?cac?cac?cgc?gta?tcc?atc?acc?gat?ggt?gct?ctt?act 355

Arg?Tyr?Glu?Ala?His?His?Arg?Val?Ser?Ile?Thr?Asp?Gly?Ala?Leu?Thr

70 75 80 85

gca?gca?gct?cag?ctt?gct?gat?cgc?tac?atc?aac?gac?cgc?ttc?ttg?cca 403

Ala?Ala?Ala?Gln?Leu?Ala?Asp?Arg?Tyr?Ile?Asn?Asp?Arg?Phe?Leu?Pro

90 95 100

gat?aag?gcc?gtt?gac?ctc?atc?gat?gag?gct?ggc?gcc?cgc?atg?cgc?atc 451

Asp?Lys?Ala?Val?Asp?Leu?Ile?Asp?Glu?Ala?Gly?Ala?Arg?Met?Arg?Ile

105 110 115

aag?cgc?atg?acc?gca?cct?tcc?tcc?ctc?cgc?gag?gtt?gat?gag?cgt?atc 499

Lys?Arg?Met?Thr?Ala?Pro?Ser?Ser?Leu?Arg?Glu?Val?Asp?Glu?Arg?Ile

120 125 130

gct?gat?gtt?cgc?cgt?gag?aag?gaa?gca?gcg?atc?gat?gct?cag?gac?ttt 547

Ala?Asp?Val?Arg?Arg?Glu?Lys?Glu?Ala?Ala?Ile?Asp?Ala?Gln?Asp?Phe

135 140 145

gag?aag?gca?gca?ggt?ctt?cgc?gat?aag?gag?cgc?aag?ctc?ggc?gaa?gag 595

Glu?Lys?Ala?Ala?Gly?Leu?Arg?Asp?Lys?Glu?Arg?Lys?Leu?Gly?Glu?Glu

150 155 160 165

cgt?tca?gag?aag?gaa?aag?cag?tgg?cgc?tcc?ggc?gac?ctc?gag?gac?atc 643

Arg?Ser?Glu?Lys?Glu?Lys?Gln?Trp?Arg?Ser?Gly?Asp?Leu?Glu?Asp?Ile

170 175 180

gct?gag?gtt?ggc?gaa?gag?cag?atc?gca?gaa?gta?ctg?gcc?aac?tgg?act 691

Ala?Glu?Val?Gly?Glu?Glu?Gln?Ile?Ala?Glu?Val?Leu?Ala?Asn?Trp?Thr

185 190 195

ggt?att?cct?gtc?ttc?aag?ctc?acc?gaa?gct?gaa?tct?tca?cgc?ctg?ctc 739

Gly?Ile?Pro?Val?Phe?Lys?Leu?Thr?Glu?Ala?Glu?Ser?Ser?Arg?Leu?Leu

200 205 210

aac?atg?gaa?gaa?gag?ttg?cac?aag?cgc?atc?atc?gga?cag?gat?gaa?gct 787

Asn?Met?Glu?Glu?Glu?Leu?His?Lys?Arg?Ile?Ile?Gly?Gln?Asp?Glu?Ala

215 220 225

gtc?aag?gct?gtc?tcc?cgt?gcg?atc?cgt?cgt?acc?cgt?gca?ggt?ctg?aag 835

Val?Lys?Ala?Val?Ser?Arg?Ala?Ile?Arg?Arg?Thr?Arg?Ala?Gly?Leu?Lys

230 235 240 245

gat?cct?aag?cgt?cct?tcc?ggc?tcc?ttc?atc?ttc?gct?ggt?cca?tcc?ggc 883

Asp?Pro?Lys?Arg?Pro?Ser?Gly?Ser?Phe?Ile?Phe?Ala?Gly?Pro?Ser?Gly

250 255 260

gtt?ggt?aag?acc?gag?ctg?tcc?aag?gct?ctc?gca?gga?ttc?ctc?ttc?ggt 931

Val?Gly?Lys?Thr?Glu?Leu?Ser?Lys?Ala?Leu?Ala?Gly?Phe?Leu?Phe?Gly

265 270 275

gac?gat?gat?tcc?ctc?atc?caa?atc?gac?atg?ggt?gag?ttc?cac?gac?cgc 979

Asp?Asp?Asp?Ser?Leu?Ile?Gln?Ile?Asp?Met?Gly?Glu?Phe?His?Asp?Arg

280 285 290

ttc?acc?gcg?tcc?cga?ctt?ttc?ggt?gcc?cct?ccg?gga?tac?gtt?ggc?tac 1027

Phe?Thr?Ala?Ser?Arg?Leu?Phe?Gly?Ala?Pro?Pro?Gly?Tyr?Val?Gly?Tyr

295 300 305

gaa?gaa?ggt?ggc?cag?ctg?acc?gag?aag?gtt?cgc?cgt?aag?cca?ttc?tcc 1075

Glu?Glu?Gly?Gly?Gln?Leu?Thr?Glu?Lys?Val?Arg?Arg?Lys?Pro?Phe?Ser

310 315 320 325

gtt?gtg?ctt?ttc?gac?gaa?atc?gag?aag?gcc?cac?aag?gag?atc?tac?aac 1123

Val?Val?Leu?Phe?Asp?Glu?Ile?Glu?Lys?Ala?His?Lys?Glu?Ile?Tyr?Asn

330 335 340

acc?ttg?ctg?cag?gtg?ttg?gaa?gat?ggt?cgc?ctt?acc?gat?ggt?cag?gga 1171

Thr?Leu?Leu?Gln?Val?Leu?Glu?Asp?Gly?Arg?Leu?Thr?Asp?Gly?Gln?Gly

345 350 355

cgc?atc?gtg?gac?ttc?aag?aac?acc?gtc?ctg?atc?ttc?acc?tcc?aac?ctg 1219

Arg?Ile?Val?Asp?Phe?Lys?Asn?Thr?Val?Leu?Ile?Phe?Thr?Ser?Asn?Leu

360 365 370

ggc?acc?gct?gac?atc?tcc?aag?gct?gtt?ggc?ctg?ggc?ttc?tcc?gga?tcc 1267

Gly?Thr?Ala?Asp?Ile?Ser?Lys?Ala?Val?Gly?Leu?Gly?Phe?Ser?Gly?Ser

375 380 385

tcc?gag?act?gac?agc?gat?gct?cag?tac?gac?cgc?atg?aag?aac?aag?gtc 1315

Ser?Glu?Thr?Asp?Ser?Asp?Ala?Gln?Tyr?Asp?Arg?Met?Lys?Asn?Lys?Val

390 395 400 405

cac?gac?gag?ctg?aag?aag?cac?ttc?cgc?cct?gag?ttc?ctg?aac?cgt?att 1363

His?Asp?Glu?Leu?Lys?Lys?His?Phe?Arg?Pro?Glu?Phe?Leu?Asn?Arg?Ile

410 415 420

gat?gag?atc?gtg?gtc?ttc?cac?cag?ctc?acc?aag?gat?cag?atc?gtt?cag 1411

Asp?Glu?Ile?Val?Val?Phe?His?Gln?Leu?Thr?Lys?Asp?Gln?Ile?Val?Gln

425 430 435

atg?gtc?gac?ctt?ctt?atc?ggt?cgc?gtt?tcc?aac?gca?ctg?gct?gag?aag 1459

Met?Val?Asp?Leu?Leu?Ile?Gly?Arg?Val?Ser?Asn?Ala?Leu?Ala?Glu?Lys

440 445 450

gac?atg?agc?atc?gaa?ctg?act?gag?aag?gcc?aag?gac?ctc?ctg?gct?aac 1507

Asp?Met?Ser?Ile?Glu?Leu?Thr?Glu?Lys?Ala?Lys?Asp?Leu?Leu?Ala?Asn

455 460 465

cga?ggc?ttc?gat?cca?gtt?ctg?ggt?gca?cga?cca?ttg?cgt?cgc?acc?atc 1555

Arg?Gly?Phe?Asp?Pro?Val?Leu?Gly?Ala?Arg?Pro?Leu?Arg?Arg?Thr?Ile

470 475 480 485

cag?cgc?gaa?att?gaa?gac?cag?atg?tcc?gag?aag?atc?ctc?ttc?ggt?gaa 1603

Gln?Arg?Glu?Ile?Glu?Asp?Gln?Met?Ser?Glu?Lys?Ile?Leu?Phe?Gly?Glu

490 495 500

atc?ggc?gca?ggc?gag?atc?gtc?acc?gtt?gac?gtc?gaa?ggc?tgg?gac?ggc 1651

Ile?Gly?Ala?Gly?Glu?Ile?Val?Thr?Val?Asp?Val?Glu?Gly?Trp?Asp?Gly

505 510 515

gag?tcc?aag?gac?acc?gac?cgt?gcg?aag?ttc?acc?ttc?aca?cca?cgt?cca 1699

Glu?Ser?Lys?Asp?Thr?Asp?Arg?Ala?Lys?Phe?Thr?Phe?Thr?Pro?Arg?Pro

520 525 530

aag?cca?atg?cca?gaa?ggt?aag?ttc?tct?gag?atc?tct?gtc?gag?gct?gcg 1747

Lys?Pro?Met?Pro?Glu?Gly?Lys?Phe?Ser?Glu?Ile?Ser?Val?Glu?Ala?Ala

535 540 545

gaa?gca?att?caa?gat?gta?gat?tct?gca?gct?gac?ggc?gat?gtc?cca?gaa 1795

Glu?Ala?Ile?Gln?Asp?Val?Asp?Ser?Ala?Ala?Asp?Gly?Asp?Val?Pro?Glu

550 555 560 565

acc?gat?tca?ctt?tcc?gac?att?gac?ctt?gaa?acc?ctt?gaa?aag?ttt?gag 1843

Thr?Asp?Ser?Leu?Ser?Asp?Ile?Asp?Leu?Glu?Thr?Leu?Glu?Lys?Phe?Glu

570 575 580

gaa?gat?gta?gaa?aac?ggc?acc?gac?att?gat?cag?gtg?tcc?ggt?gac?tac 1891

Glu?Asp?Val?Glu?Asn?Gly?Thr?Asp?Ile?Asp?Gln?Val?Ser?Gly?Asp?Tyr

585 590 595

tac?ggc?acc?gat?gat?cag?gga?ggc?act?gct?cca?agc?aag?gag 1933

Tyr?Gly?Thr?Asp?Asp?Gln?Gly?Gly?Thr?Ala?Pro?Ser?Lys?Glu

600 605 610

tagcaacctt?ttgaaaaagg?gcc 1956

<210>54

<211>611

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>54

Val?Gln?His?Glu?Gly?Ala?Ile?Asp?Ala?Ala?Ser?Leu?Leu?Lys?Pro?Lys

1 5 10 15

Leu?Ala?Arg?Gly?Glu?Leu?Gln?Thr?Ile?Gly?Ala?Thr?Thr?Leu?Asp?Glu

20 25 30

Tyr?Arg?Lys?His?Ile?Glu?Lys?Asp?Ala?Ala?Leu?Glu?Arg?Arg?Phe?Gln

35 40 45

Pro?Val?Gln?Val?Pro?Glu?Pro?Ser?Val?Asp?Leu?Thr?Val?Glu?Ile?Leu

50 55 60

Lys?Gly?Leu?Arg?Asp?Arg?Tyr?Glu?Ala?His?His?Arg?Val?Ser?Ile?Thr

65 70 75 80

Asp?Gly?Ala?Leu?Thr?Ala?Ala?Ala?Gln?Leu?Ala?Asp?Arg?Tyr?Ile?Asn

85 90 95

Asp?Arg?Phe?Leu?Pro?Asp?Lys?Ala?Val?Asp?Leu?Ile?Asp?Glu?Ala?Gly

100 105 110

Ala?Arg?Met?Arg?Ile?Lys?Arg?Met?Thr?Ala?Pro?Ser?Ser?Leu?Arg?Glu

115 120 125

Val?Asp?Glu?Arg?Ile?Ala?Asp?Val?Arg?Arg?Glu?Lys?Glu?Ala?Ala?Ile

130 135 140

Asp?Ala?Gln?Asp?Phe?Glu?Lys?Ala?Ala?Gly?Leu?Arg?Asp?Lys?Glu?Arg

145 150 155 160

Lys?Leu?Gly?Glu?Glu?Arg?Ser?Glu?Lys?Glu?Lys?Gln?Trp?Arg?Ser?Gly

165 170 175

Asp?Leu?Glu?Asp?Ile?Ala?Glu?Val?Gly?Glu?Glu?Gln?Ile?Ala?Glu?Val

180 185 190

Leu?Ala?Asn?Trp?Thr?Gly?Ile?Pro?Val?Phe?Lys?Leu?Thr?Glu?Ala?Glu

195 200 205

Ser?Ser?Arg?Leu?Leu?Asn?Met?Glu?Glu?Glu?Leu?His?Lys?Arg?Ile?Ile

210 215 220

Gly?Gln?Asp?Glu?Ala?Val?Lys?Ala?Val?Ser?Arg?Ala?Ile?Arg?Arg?Thr

225 230 235 240

Arg?Ala?Gly?Leu?Lys?Asp?Pro?Lys?Arg?Pro?Ser?Gly?Ser?Phe?Ile?Phe

245 250 255

Ala?Gly?Pro?Ser?Gly?Val?Gly?Lys?Thr?Glu?Leu?Ser?Lys?Ala?Leu?Ala

260 265 270

Gly?Phe?Leu?Phe?Gly?Asp?Asp?Asp?Ser?Leu?Ile?Gln?Ile?Asp?Met?Gly

275 280 285

Glu?Phe?His?Asp?Arg?Phe?Thr?Ala?Ser?Arg?Leu?Phe?Gly?Ala?Pro?Pro

290 295 300

Gly?Tyr?Val?Gly?Tyr?Glu?Glu?Gly?Gly?Gln?Leu?Thr?Glu?Lys?Val?Arg

305 310 315 320

Arg?Lys?Pro?Phe?Ser?Val?Val?Leu?Phe?Asp?Glu?Ile?Glu?Lys?Ala?His

325 330 335

Lys?Glu?Ile?Tyr?Asn?Thr?Leu?Leu?Gln?Val?Leu?Glu?Asp?Gly?Arg?Leu

340 345 350

Thr?Asp?Gly?Gln?Gly?Arg?Ile?Val?Asp?Phe?Lys?Asn?Thr?Val?Leu?Ile

355 360 365

Phe?Thr?Ser?Asn?Leu?Gly?Thr?Ala?Asp?Ile?Ser?Lys?Ala?Val?Gly?Leu

370 375 380

Gly?Phe?Ser?Gly?Ser?Ser?Glu?Thr?Asp?Ser?Asp?Ala?Gln?Tyr?Asp?Arg

385 390 395 400

Met?Lys?Asn?Lys?Val?His?Asp?Glu?Leu?Lys?Lys?His?Phe?Arg?Pro?Glu

405 410 415

Phe?Leu?Asn?Arg?Ile?Asp?Glu?Ile?Val?Val?Phe?His?Gln?Leu?Thr?Lys

420 425 430

Asp?Gln?Ile?Val?Gln?Met?Val?Asp?Leu?Leu?Ile?Gly?Arg?Val?Ser?Asn

435 440 445

Ala?Leu?Ala?Glu?Lys?Asp?Met?Ser?Ile?Glu?Leu?Thr?Glu?Lys?Ala?Lys

450 455 460

Asp?Leu?Leu?Ala?Asn?Arg?Gly?Phe?Asp?Pro?Val?Leu?Gly?Ala?Arg?Pro

465 470 475 480

Leu?Arg?Arg?Thr?Ile?Gln?Arg?Glu?Ile?Glu?Asp?Gln?Met?Ser?Glu?Lys

485 490 495

Ile?Leu?Phe?Gly?Glu?Ile?Gly?Ala?Gly?Glu?Ile?Val?Thr?Val?Asp?Val

500 505 510

Glu?Gly?Trp?Asp?Gly?Glu?Ser?Lys?Asp?Thr?Asp?Arg?Ala?Lys?Phe?Thr

515 520 525

Phe?Thr?Pro?Arg?Pro?Lys?Pro?Met?Pro?Glu?Gly?Lys?Phe?Ser?Glu?Ile

530 535 540

Ser?Val?Glu?Ala?Ala?Glu?Ala?Ile?Gln?Asp?Val?Asp?Ser?Ala?Ala?Asp

545 550 555 560

Gly?Asp?Val?Pro?Glu?Thr?Asp?Ser?Leu?Ser?Asp?Ile?Asp?Leu?Glu?Thr

565 570 575

Leu?Glu?Lys?Phe?Glu?Glu?Asp?Val?Glu?Asn?Gly?Thr?Asp?Ile?Asp?Gln

580 585 590

Val?Ser?Gly?Asp?Tyr?Tyr?Gly?Thr?Asp?Asp?Gln?Gly?Gly?Thr?Ala?Pro

595 600 605

Ser?Lys?Glu

610

<210>55

<211>1446

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1423)

<223>RXA02630

<400>55

gcgggttcga?aaatgtcgat?gattaaacca?ctaaagagct?cacaggaagt?gttcagacta?60

cttagagtga?cgccccagcc?acagggttca?taatcaaatc?atg?aca?aat?caa?ttc 115

Met?Thr?Asn?Gln?Phe

1 5

ccc?aca?aac?aac?ggt?gag?aac?ccg?gac?cgt?gca?tcg?gaa?act?cca?tca 163

Pro?Thr?Asn?Asn?Gly?Glu?Asn?Pro?Asp?Arg?Ala?Ser?Glu?Thr?Pro?Ser

10 15 20

gaa?acc?aac?tcc?ttc?gaa?cat?gtg?cgt?agt?tca?tat?ccg?cag?tgg?ggt 211

Glu?Thr?Asn?Ser?Phe?Glu?His?Val?Arg?Ser?Ser?Tyr?Pro?Gln?Trp?Gly

25 30 35

aac?act?gct?tcc?aat?caa?aac?ccc?tat?cct?ggt?gcg?ggc?ttc?ggc?tct 259

Asn?Thr?Ala?Ser?Asn?Gln?Asn?Pro?Tyr?Pro?Gly?Ala?Gly?Phe?Gly?Ser

40 45 50

gaa?caa?aac?act?caa?caa?gga?aat?gag?caa?caa?gct?cca?gcc?tgg?acc 307

Glu?Gln?Asn?Thr?Gln?Gln?Gly?Asn?Glu?Gln?Gln?Ala?Pro?Ala?Trp?Thr

55 60 65

agt?tgg?gat?aat?cag?cct?cta?agc?aca?gat?gta?aag?cca?gct?aaa?gaa 355

Ser?Trp?Asp?Asn?Gln?Pro?Leu?Ser?Thr?Asp?Val?Lys?Pro?Ala?Lys?Glu

70 75 80 85

aag?cga?aaa?gtt?ggc?atc?gga?acg?gca?ctc?gcg?tta?atg?ctt?gtt?ggt 403

Lys?Arg?Lys?Val?Gly?Ile?Gly?Thr?Ala?Leu?Ala?Leu?Met?Leu?Val?Gly

90 95 100

tct?att?gct?acc?ggt?agc?gtt?gtg?ggt?gtt?gca?gca?acc?cag?ctt?ggt 451

Ser?Ile?Ala?Thr?Gly?Ser?Val?Val?Gly?Val?Ala?Ala?Thr?Gln?Leu?Gly

105 110 115

tcg?gac?tct?tca?acc?cca?gtt?aat?gct?ctt?gag?cag?ccc?agc?gtg?cag 499

Ser?Asp?Ser?Ser?Thr?Pro?Val?Asn?Ala?Leu?Glu?Gln?Pro?Ser?Val?Gln

120 125 130

cgc?acc?act?aat?gct?gaa?cca?ggt?tca?gcg?gaa?cag?gtt?gct?gcc?gca 547

Arg?Thr?Thr?Asn?Ala?Glu?Pro?Gly?Ser?Ala?Glu?Gln?Val?Ala?Ala?Ala

135 140 145

gtt?ttg?cct?tct?gtc?gtc?tct?att?cag?gcc?att?act?agg?acg?tct?gct 595

Val?Leu?Pro?Ser?Val?Val?Ser?Ile?Gln?Ala?Ile?Thr?Arg?Thr?Ser?Ala

150 155 160 165

tct?gag?ggc?tct?gga?tcc?att?att?tcc?tct?gat?ggt?tac?gtc?atg?acc 643

Ser?Glu?Gly?Ser?Gly?Ser?Ile?Ile?Ser?Ser?Asp?Gly?Tyr?Val?Met?Thr

170 175 180

aat?aat?cac?gtc?gtg?gca?ggc?att?gaa?caa?tct?ggt?gtg?tta?gaa?gta 691

Asn?Asn?His?Val?Val?Ala?Gly?Ile?Glu?Gln?Ser?Gly?Val?Leu?Glu?Val

185 190 195

agt?ttc?tcc?gat?gga?act?aca?gcg?caa?gct?gat?ttt?att?gct?ggt?gat 739

Ser?Phe?Ser?Asp?Gly?Thr?Thr?Ala?Gln?Ala?Asp?Phe?Ile?Ala?Gly?Asp

200 205 210

cct?tcc?aca?gat?att?gct?gtg?atc?aag?att?agg?gat?gtg?tcc?aac?ctt 787

Pro?Ser?Thr?Asp?Ile?Ala?Val?Ile?Lys?Ile?Arg?Asp?Val?Ser?Asn?Leu

215 220 225

cca?gtt?atg?agc?ttt?gga?gat?tcg?gac?gca?tta?ggc?gtt?gga?caa?agt 835

Pro?Val?Met?Ser?Phe?Gly?Asp?Ser?Asp?Ala?Leu?Gly?Val?Gly?Gln?Ser

230 235 240 245

gtg?atg?gct?gtt?ggt?tct?cca?ctg?ggt?ctg?agc?tcc?act?gtg?acc?acc 883

Val?Met?Ala?Val?Gly?Ser?Pro?Leu?Gly?Leu?Ser?Ser?Thr?Val?Thr?Thr

250 255 260

ggt?att?gtg?tcg?gcc?gtg?aac?cgt?cct?gtg?cga?gct?tct?ggt?gat?ggc 931

Gly?Ile?Val?Ser?Ala?Val?Asn?Arg?Pro?Val?Arg?Ala?Ser?Gly?Asp?Gly

265 270 275

gga?gag?tcg?tcc?ctc?atc?gat?gct?atc?cag?acc?gat?gct?gcg?atc?aac 979

Gly?Glu?Ser?Ser?Leu?Ile?Asp?Ala?Ile?Gln?Thr?Asp?Ala?Ala?Ile?Asn

280 285 290

cct?ggt?aac?tct?ggt?ggt?ccg?ctg?gtt?gat?atg?gat?ggc?aac?ctc?att 1027

Pro?Gly?Asn?Ser?Gly?Gly?Pro?Leu?Val?Asp?Met?Asp?Gly?Asn?Leu?Ile

295 300 305

ggc?atg?aat?tcg?gta?att?gca?tcg?att?tcg?agc?acc?agc?gat?tcc?gca 1075

Gly?Met?Asn?Ser?Val?Ile?Ala?Ser?Ile?Ser?Ser?Thr?Ser?Asp?Ser?Ala

310 315 320 325

ggt?tcc?att?ggt?ctt?ggt?ttt?tct?atc?cca?tcc?aac?ttt?gcc?aag?cgc 1123

Gly?Ser?Ile?Gly?Leu?Gly?Phe?Ser?Ile?Pro?Ser?Asn?Phe?Ala?Lys?Arg

330 335 340

gtg?gcc?gat?caa?ttg?atc?agc?acc?ggc?cag?gta?act?cag?ccg?atg?atc 1171

Val?Ala?Asp?Gln?Leu?Ile?Ser?Thr?Gly?Gln?Val?Thr?Gln?Pro?Met?Ile

345 350 355

ggt?gtg?cag?gtt?ggc?act?gac?aac?tca?gtg?aca?ggc?gct?gtg?att?gcc 1219

Gly?Val?Gln?Val?Gly?Thr?Asp?Asn?Ser?Val?Thr?Gly?Ala?Val?Ile?Ala

360 365 370

agt?gtt?caa?gat?ggt?gga?ccg?gcc?gca?gat?gct?gga?ctt?cag?cca?ggc 1267

Ser?Val?Gln?Asp?Gly?Gly?Pro?Ala?Ala?Asp?Ala?Gly?Leu?Gln?Pro?Gly

375 380 385

gat?atc?gtg?acc?aag?ctc?aat?gat?cga?gtt?att?gat?agc?cca?gac?tcc 1315

Asp?Ile?Val?Thr?Lys?Leu?Asn?Asp?Arg?Val?Ile?Asp?Ser?Pro?Asp?Ser

390 395 400 405

ttg?atc?gct?gct?gtt?cgt?tcg?cat?gat?ttt?ggc?gaa?acc?gtc?act?tta 1363

Leu?Ile?Ala?Ala?Val?Arg?Ser?His?Asp?Phe?Gly?Glu?Thr?Val?Thr?Leu

410 415 420

aca?att?aca?cag?cca?gat?acc?tcg?cag?agc?cgg?gag?gta?gag?gtt?act 1411

Thr?Ile?Thr?Gln?Pro?Asp?Thr?Ser?Gln?Ser?Arg?Glu?Val?Glu?Val?Thr

425 430 435

ctg?acg?agt?gag?taggtttaaa?agagttaatc?tgc 1446

Leu?Thr?Ser?Glu

440

<210>56

<211>441

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>56

Met?Thr?Asn?Gln?Phe?Pro?Thr?Asn?Asn?Gly?Glu?Asn?Pro?Asp?Arg?Ala

1 5 10 15

Ser?Glu?Thr?Pro?Ser?Glu?Thr?Asn?Ser?Phe?Glu?His?Val?Arg?Ser?Ser

20 25 30

Tyr?Pro?Gln?Trp?Gly?Asn?Thr?Ala?Ser?Asn?Gln?Asn?Pro?Tyr?Pro?Gly

35 40 45

Ala?Gly?Phe?Gly?Ser?Glu?Gln?Asn?Thr?Gln?Gln?Gly?Asn?Glu?Gln?Gln

50 55 60

Ala?Pro?Ala?Trp?Thr?Ser?Trp?Asp?Asn?Gln?Pro?Leu?Ser?Thr?Asp?Val

65 70 75 80

Lys?Pro?Ala?Lys?Glu?Lys?Arg?Lys?Val?Gly?Ile?Gly?Thr?Ala?Leu?Ala

85 90 95

Leu?Met?Leu?Val?Gly?Ser?Ile?Ala?Thr?Gly?Ser?Val?Val?Gly?Val?Ala

100 105 110

Ala?Thr?Gln?Leu?Gly?Ser?Asp?Ser?Ser?Thr?Pro?Val?Asn?Ala?Leu?Glu

115 120 125

Gln?Pro?Ser?Val?Gln?Arg?Thr?Thr?Asn?Ala?Glu?Pro?Gly?Ser?Ala?Glu

130 135 140

Gln?Val?Ala?Ala?Ala?Val?Leu?Pro?Ser?Val?Val?Ser?Ile?Gln?Ala?Ile

145 150 155 160

Thr?Arg?Thr?Ser?Ala?Ser?Glu?Gly?Ser?Gly?Ser?Ile?Ile?Ser?Ser?Asp

165 170 175

Gly?Tyr?Val?Met?Thr?Asn?Asn?His?Val?Val?Ala?Gly?Ile?Glu?Gln?Ser

180 185 190

Gly?Val?Leu?Glu?Val?Ser?Phe?Ser?Asp?Gly?Thr?Thr?Ala?Gln?Ala?Asp

195 200 205

Phe?Ile?Ala?Gly?Asp?Pro?Ser?Thr?Asp?Ile?Ala?Val?Ile?Lys?Ile?Arg

210 215 220

Asp?Val?Ser?Asn?Leu?Pro?Val?Met?Ser?Phe?Gly?Asp?Ser?Asp?Ala?Leu

225 230 235 240

Gly?Val?Gly?Gln?Ser?Val?Met?Ala?Val?Gly?Ser?Pro?Leu?Gly?Leu?Ser

245 250 255

Ser?Thr?Val?Thr?Thr?Gly?Ile?Val?Ser?Ala?Val?Asn?Arg?Pro?Val?Arg

260 265 270

Ala?Ser?Gly?Asp?Gly?Gly?Glu?Ser?Ser?Leu?Ile?Asp?Ala?Ile?Gln?Thr

275 280 285

Asp?Ala?Ala?Ile?Asn?Pro?Gly?Asn?Ser?Gly?Gly?Pro?Leu?Val?Asp?Met

290 295 300

Asp?Gly?Asn?Leu?Ile?Gly?Met?Asn?Ser?Val?Ile?Ala?Ser?Ile?Ser?Ser

305 310 315 320

Thr?Ser?Asp?Ser?Ala?Gly?Ser?Ile?Gly?Leu?Gly?Phe?Ser?Ile?Pro?Ser

325 330 335

Asn?Phe?Ala?Lys?Arg?Val?Ala?Asp?Gln?Leu?Ile?Ser?Thr?Gly?Gln?Val

340 345 350

Thr?Gln?Pro?Met?Ile?Gly?Val?Gln?Val?Gly?Thr?Asp?Asn?Ser?Val?Thr

355 360 365

Gly?Ala?Val?Ile?Ala?Ser?Val?Gln?Asp?Gly?Gly?Pro?Ala?Ala?Asp?Ala

370 375 380

Gly?Leu?Gln?Pro?Gly?Asp?Ile?Val?Thr?Lys?Leu?Asn?Asp?Arg?Val?Ile

385 390 395 400

Asp?Ser?Pro?Asp?Ser?Leu?Ile?Ala?Ala?Val?Arg?Ser?His?Asp?Phe?Gly

405 410 415

Glu?Thr?Val?Thr?Leu?Thr?Ile?Thr?Gln?Pro?Asp?Thr?Ser?Gln?Ser?Arg

420 425 430

Glu?Val?Glu?Val?Thr?Leu?Thr?Ser?Glu

435 440

<210>57

<211>518

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(495)

<223>RXA02834

<400>57

gat?tct?aaa?ggt?aga?agt?gtt?gac?ttt?aaa?aat?acc?att?atc?atc?atg 48

Asp?Ser?Lys?Gly?Arg?Ser?Val?Asp?Phe?Lys?Asn?Thr?Ile?Ile?Ile?Met

1 5 10 15

act?agt?aat?att?ggt?tca?caa?gta?tta?ctt?gaa?aat?gta?aaa?gat?gct 96

Thr?Ser?Asn?Ile?Gly?Ser?Gln?Val?Leu?Leu?Glu?Asn?Val?Lys?Asp?Ala

20 25 30

ggt?gaa?att?agt?gat?gat?aca?gag?aaa?gca?gtt?atg?gac?agt?cta?cat 144

Gly?Glu?Ile?Ser?Asp?Asp?Thr?Glu?Lys?Ala?Val?Met?Asp?Ser?Leu?His

35 40 45

gca?tacttc?aaa?cct?gaa?ata?tta?aat?cgt?atg?gat?gac?atc?gtg?tta 192

Ala?Tyr?Phe?Lys?Pro?Glu?Ile?Leu?Asn?Arg?Met?Asp?Asp?Ile?Val?Leu

50 55 60

ttt?aaa?cca?tta?tca?gtt?aat?gat?atg?agt?atg?att?gta?gat?aaa?att 240

Phe?Lys?Pro?Leu?Ser?Val?Asn?Asp?Met?Ser?Met?Ile?Val?Asp?Lys?Ile

65 70 75 80

tta?aca?caa?tta?aat?atg?aga?tta?tta?gat?caa?cat?atc?tca?att?gaa 288

Leu?Thr?Gln?Leu?Asn?Met?Arg?Leu?Leu?Asp?Gln?His?Ile?Ser?Ile?Glu

85 90 95

gtg?aca?gaa?gaa?gcg?aaa?aaa?tgg?cta?ggt?gaa?gaa?gcg?tat?gaa?cca 336

Val?Thr?Glu?Glu?Ala?Lys?Lys?Trp?Leu?Gly?Glu?Glu?Ala?Tyr?Glu?Pro

100 105 110

caa?ttt?ggt?gca?aga?cca?tta?aaa?cgc?ttt?gtt?caa?cga?caa?ata?gaa 384

Gln?Phe?Gly?Ala?Arg?Pro?Leu?Lys?Arg?Phe?Val?Gln?Arg?Gln?Ile?Glu

115 120 125

act?cca?att?gca?cgt?atg?atg?att?aaa?gaa?agt?cta?cct?gaa?ggt?aca 432

Thr?Pro?Ile?Ala?Arg?Met?Met?Ile?Lys?Glu?Ser?Leu?Pro?Glu?Gly?Thr

130 135 140

ata?att?aaa?gta?gat?tta?aat?gac?aat?aaa?gaa?ctt?gat?ttt?aag?gtt 480

Ile?Ile?Lys?Val?Asp?Leu?Asn?Asp?Asn?Lys?Glu?Leu?Asp?Phe?Lys?Val

145 150 155 160

gtt?aaa?cct?acg?tct?taatctagca?aaatattaat?ttg 518

Val?Lys?Pro?Thr?Ser

165

<210>58

<211>165

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>58

Asp?Ser?Lys?Gly?Arg?Ser?Val?Asp?Phe?Lys?Asn?Thr?Ile?Ile?Ile?Met

1 5 10 15

Thr?Ser?Asn?Ile?Gly?Ser?Gln?Val?Leu?Leu?Glu?Asn?Val?Lys?Asp?Ala

20 25 30

Gly?Glu?Ile?Ser?Asp?Asp?Thr?Glu?Lys?Ala?Val?Met?Asp?Ser?Leu?His

35 40 45

Ala?Tyr?Phe?Lys?Pro?Glu?Ile?Leu?Asn?Arg?Met?Asp?Asp?Ile?Val?Leu

50 55 60

Phe?Lys?Pro?Leu?Ser?Val?Asn?Asp?Met?Ser?Met?Ile?Val?Asp?Lys?Ile

65 70 75 80

Leu?Thr?Gln?Leu?Asn?Met?Arg?Leu?Leu?Asp?Gln?His?Ile?Ser?Ile?Glu

85 90 95

Val?Thr?Glu?Glu?Ala?Lys?Lys?Trp?Leu?Gly?Glu?Glu?Ala?Tyr?Glu?Pro

100 105 110

Gln?Phe?Gly?Ala?Arg?Pro?Leu?Lys?Arg?Phe?Val?Gln?Arg?Gln?Ile?Glu

115 120 125

Thr?Pro?Ile?Ala?Arg?Met?Met?Ile?Lys?Glu?Ser?Leu?Pro?Glu?Gly?Thr

130 135 140

Ile?Ile?Lys?Val?Asp?Leu?Asn?Asp?Asn?Lys?Glu?Leu?Asp?Phe?Lys?Val

145 150 155 160

Val?Lys?Pro?Thr?Ser

165

<210>59

<211>1314

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterriumglutamicum)

<220>

<221>CDS

<222>(101)..(1291)

<223>RXA00112

<400>59

gcgttaggct?gacgggctcc?ggtggcctaa?aatcgaagcg?atctaaaaat?ttggcagtta?60

atattatcga?ttttcgaaag?cgtagaacac?caaaccattg?ttg?agc?ccc?agc?ctg 115

Leu?Ser?Pro?Ser?Leu

1 5

gtc?gtc?gat?gcc?gtc?atc?gtc?ctc?gtt?atg?gca?ttc?gcc?ctg?tgg?ggt 163

Va1?Val?Asp?Ala?Val?Ile?Val?Leu?Val?Met?Ala?Phe?Ala?Leu?Trp?Gly

10 15 20

ggt?tgg?cgt?caa?ggc?gcc?ttc?acc?tcg?ctg?ctg?tcc?acc?gtc?ggc?gtc 211

Gly?Trp?Arg?Gln?Gly?Ala?Phe?Thr?Ser?Leu?Leu?Ser?Thr?Val?Gly?Val

25 30 35

gtt?tct?ggc?ctg?gta?gtt?ggc?gca?gca?gca?gct?cca?ttt?gtc?atg?ggt 259

Val?Ser?Gly?Leu?Val?Val?Gly?Ala?Ala?Ala?Ala?Pro?Phe?Val?Met?Gly

40 45 50

ctc?acc?gat?tcc?acc?gcg?ctt?cgc?ttc?ctc?ctg?gcg?atc?ggc?acc?gtg 307

Leu?Thr?Asp?Ser?Thr?Ala?Leu?Arg?Phe?Leu?Leu?Ala?Ile?Gly?Thr?Val

55 60 65

gtg?ctg?ctg?gtt?ggt?ttg?gga?aat?ctc?atc?ggc?gcc?cac?ttg?ggt?gct 355

Val?Leu?Leu?Val?Gly?Leu?Gly?Asn?Leu?Ile?Gly?Ala?His?Leu?Gly?Ala

70 75 80 85

gcg?att?aga?gac?aac?atc?aaa?ttc?cga?agt?tcc?agg?acc?tta?gat?tct 403

Ala?Ile?Arg?Asp?Asn?Ile?Lys?Phe?Arg?Ser?Ser?Arg?Thr?Leu?Asp?Ser

90 95 100

ggg?ctc?ggc?gcc?att?ttc?caa?gta?ttg?gcc?acc?ttg?atc?gtg?gtg?tgg 451

Gly?Leu?Gly?Ala?Ile?Phe?Gln?Val?Leu?Ala?Thr?Leu?Ile?Val?Val?Trp

105 110 115

ctc?gtc?gca?att?ccc?ctg?gcc?aca?ggc?ctc?ccc?gga?act?gtc?gcc?agc 499

Leu?Val?Ala?Ile?Pro?Leu?Ala?Thr?Gly?Leu?Pro?Gly?Thr?Val?Ala?Ser

120 125 130

gga?att?aga?gac?tcc?cgc?atc?ctg?ggc?ttt?gta?gac?aaa?tac?acc?ccg 547

Gly?Ile?Arg?Asp?Ser?Arg?Ile?Leu?Gly?Phe?Val?Asp?Lys?Tyr?Thr?Pro

135 140 145

caa?ggc?cta?gat?acc?ctg?ccc?tcc?aaa?atc?gct?gcg?atg?ctc?agc?gaa 595

Gln?Gly?Leu?Asp?Thr?Leu?Pro?Ser?Lys?Ile?Ala?Ala?Met?Leu?Ser?Glu

150 155 160 165

tcc?ggc?ctc?cca?cca?ctg?att?tcc?ccc?ttc?acc?ggc?gga?tcc?tcg?gtg 643

Ser?Gly?Leu?Pro?Pro?Leu?Ile?Ser?Pro?Phe?Thr?Gly?Gly?Ser?Ser?Val

170 175 180

gaa?gtg?gac?gcc?ccc?gaa?atc?aac?gtc?acc?aac?gtt?gac?cta?gtc?gaa 691

Glu?Val?Asp?Ala?Pro?Glu?Ile?Asn?Val?Thr?Asn?Val?Asp?Leu?Val?Glu

185 190 195

gca?atg?cgc?ccg?tcc?gtc?atc?cac?gtg?atg?ggt?gac?gcc?caa?gaa?tgc 739

Ala?Met?Arg?Pro?Ser?Val?Ile?His?Val?Met?Gly?Asp?Ala?Gln?Glu?Cys

200 205 210

agc?cgc?cga?ctc?atg?ggt?tct?ggc?ttt?gtg?gca?tcc?ccc?gac?tac?gtt 787

Ser?Arg?Arg?Leu?Met?Gly?Ser?Gly?Phe?Val?Ala?Ser?Pro?Asp?Tyr?Val

215 220 225

gtg?acc?aac?gcc?cac?gtt?gtt?gca?ggt?acc?tcc?acc?gtc?agc?ctg?gat 835

Val?Thr?Asn?Ala?His?Val?Val?Ala?Gly?Thr?Ser?Thr?Val?Ser?Leu?Asp

230 235 240 245

acc?atg?atc?gga?acc?cgc?tcc?gca?gag?gta?gtg?ttc?tac?gac?ccg?aac 883

Thr?Met?Ile?Gly?Thr?Arg?Ser?Ala?Glu?Val?Val?Phe?Tyr?Asp?Pro?Asn

250 255 260

ctg?gac?atc?gca?gtc?ctt?tac?agc?cct?gac?ctc?ggc?ttg?gat?cca?ctg 931

Leu?Asp?Ile?Ala?Val?Leu?Tyr?Ser?Pro?Asp?Leu?Gly?Leu?Asp?Pro?Leu

265 270 275

ccg?tgg?gca?tcc?act?ccg?cta?gac?act?ggc?gat?gaa?gca?atc?gtc?atg 979

Pro?Trp?Ala?Ser?Thr?Pro?Leu?Asp?Thr?Gly?Asp?Glu?Ala?Ile?Val?Met

280 285 290

gga?ttc?cca?cag?tcc?gga?cct?ttc?aac?gcc?tcc?cca?gcc?agg?gtc?cgc 1027

Gly?Phe?Pro?Gln?Ser?Gly?Pro?Phe?Asn?Ala?Ser?Pro?Ala?Arg?Val?Arg

295 300 305

gaa?cgc?atc?atg?atc?acc?ggc?agc?aac?att?tac?gcc?aac?ggc?cag?cac 1075

Glu?Arg?Ile?Met?Ile?Thr?Gly?Ser?Asn?Ile?Tyr?Ala?Asn?Gly?Gln?His

310 315 320 325

gaa?cgc?gaa?gcc?tat?tca?gtc?cgc?gga?tcc?atc?caa?tct?gga?aac?tcc 1123

Glu?Arg?Glu?Ala?Tyr?Ser?Val?Arg?Gly?Ser?Ile?Gln?Ser?Gly?Asn?Ser

330 335 340

ggc?ggc?cca?atg?acc?aac?gaa?atg?ggt?gaa?gtg?gtt?ggt?gtt?gtc?ttc 1171

Gly?Gly?Pro?Met?Thr?Asn?Glu?Met?Gly?Glu?Val?Val?Gly?Val?Val?Phe

345 350 355

ggc?gca?gcg?atc?gac?ggc?tcc?gat?acc?ggt?tac?gtt?ctc?act?gcc?gaa 1219

Gly?Ala?Ala?Ile?Asp?Gly?Ser?Asp?Thr?Gly?Tyr?Val?Leu?Thr?Ala?Glu

360 365 370

gag?gta?cag?gag?cgg?atc?ggc?gac?atc?acc?gcg?ctg?act?cag?cct?gtc 1267

Glu?Val?Gln?Glu?Arg?Ile?Gly?Asp?Ile?Thr?Ala?Leu?Thr?Gln?Pro?Val

375 380 385

gat?acg?atg?cag?tgc?gcg?gtt?tct?tagtcgtcgg?gagctaggac?cag 1314

Asp?Thr?Met?Gln?Cys?Ala?Val?Ser

390 395

<210>60

<211>397

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>60

Leu?Ser?Pro?Ser?Leu?Val?Val?Asp?Ala?Val?Ile?Val?Leu?Val?Met?Ala

1 5 10 15

Phe?Ala?Leu?Trp?Gly?Gly?Trp?Arg?Gln?Gly?Ala?Phe?Thr?Ser?Leu?Leu

20 25 30

Ser?Thr?Val?Gly?Val?Val?Ser?Gly?Leu?Val?Val?Gly?Ala?Ala?Ala?Ala

35 40 45

Pro?Phe?Val?Met?Gly?Leu?Thr?Asp?Ser?Thr?Ala?Leu?Arg?Phe?Leu?Leu

50 55 60

Ala?Ile?Gly?Thr?Val?Val?Leu?Leu?Val?Gly?Leu?Gly?Asn?Leu?Ile?Gly

65 70 75 80

Ala?His?Leu?Gly?Ala?Ala?Ile?Arg?Asp?Asn?Ile?Lys?Phe?Arg?Ser?Ser

85 90 95

Arg?Thr?Leu?Asp?Ser?Gly?Leu?Gly?Ala?Ile?Phe?Gln?Val?Leu?Ala?Thr

100 105 110

Leu?Ile?Val?Val?Trp?Leu?Va1?Ala?Ile?Pro?Leu?Ala?Thr?Gly?Leu?Pro

115 120 125

Gly?Thr?Val?Ala?Ser?Gly?Ile?Arg?Asp?Ser?Arg?Ile?Leu?Gly?Phe?Val

130 135 140

Asp?Lys?Tyr?Thr?Pro?Gln?Gly?Leu?Asp?Thr?Leu?Pro?Ser?Lys?Ile?Ala

145 150 155 160

Ala?Met?Leu?Ser?Glu?Ser?Gly?Leu?Pro?Pro?Leu?Ile?Ser?Pro?Phe?Thr

165 170 175

Gly?Gly?Ser?Ser?Val?Glu?Val?Asp?Ala?Pro?Glu?Ile?Asn?Val?Thr?Asn

180 185 190

Val?Asp?Leu?Val?Glu?Ala?Met?Arg?Pro?Ser?Val?Ile?His?Val?Met?Gly

195 200 205

Asp?Ala?Gln?Glu?Cys?Ser?Arg?Arg?Leu?Met?Gly?Ser?Gly?Phe?Val?Ala

210 215 220

Ser?Pro?Asp?Tyr?Val?Val?Thr?Asn?Ala?His?Val?Val?Ala?Gly?Thr?Ser

225 230 235 240

Thr?Val?Ser?Leu?Asp?Thr?Met?Ile?Gly?Thr?Arg?Ser?Ala?Glu?Val?Val

245 250 255

Phe?Tyr?Asp?Pro?Asn?Leu?Asp?Ile?Ala?Val?Leu?Tyr?Ser?Pro?Asp?Leu

260 265 270

Gly?Leu?Asp?Pro?Leu?Pro?Trp?Ala?Ser?Thr?Pro?Leu?Asp?Thr?Gly?Asp

275 280 285

Glu?Ala?Ile?Val?Met?Gly?Phe?Pro?Gln?Ser?Gly?Pro?Phe?Asn?Ala?Ser

290 295 300

Pro?Ala?Arg?Val?Arg?Glu?Arg?Ile?Met?Ile?Thr?Gly?Ser?Asn?Ile?Tyr

305 310 315 320

Ala?Asn?Gly?Gln?His?Glu?Arg?Glu?Ala?Tyr?Ser?Val?Arg?Gly?Ser?Ile

325 330 335

Gln?Ser?Gly?Asn?Ser?Gly?Gly?Pro?Met?Thr?Asn?Glu?Met?Gly?Glu?Val

340 345 350

Val?Gly?Val?Val?Phe?Gly?Ala?Ala?Ile?Asp?Gly?Ser?Asp?Thr?Gly?Tyr

355 360 365

Val?Leu?Thr?Ala?Glu?Glu?Val?Gln?Glu?Arg?Ile?Gly?Asp?Ile?Thr?Ala

370 375 380

Leu?Thr?Gln?Pro?Val?Asp?Thr?Met?Gln?Cys?Ala?Val?Ser

385 390 395

<210>61

<211>729

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(706)

<223>RXA00566

<400>61

cttgttgacc?acgtgattac?cttggctgaa?ggcccaatca?gcaactaggc?gcacggaaaa?60

ctttaaagga?gagaataaga?ttatgagcag?cggattccaa?atg?cca?acg?tcc?cgt 115

Met?Pro?Thr?Ser?Arg

1 5

tac?gtg?ctg?cct?tcc?ttc?att?gag?cag?tcc?gca?tac?ggc?acc?aaa?gag 163

Tyr?Val?Leu?Pro?Ser?Phe?Ile?Glu?Gln?Ser?Ala?Tyr?Gly?Thr?Lys?Glu

10 15 20

acc?aac?cct?tac?gca?aaa?ctc?ttt?gaa?gag?cgc?atc?atc?ttc?ctg?ggc 211

Thr?Asn?Pro?Tyr?Ala?Lys?Leu?Phe?Glu?Glu?Arg?Ile?Ile?Phe?Leu?Gly

25 30 35

acc?cag?gtc?gac?gac?acc?tct?gca?aac?gac?atc?atg?gcg?cag?ctc?ctt 259

Thr?Gln?Val?Asp?Asp?Thr?Ser?Ala?Asn?Asp?Ile?Met?Ala?Gln?Leu?Leu

40 45 50

gtc?ctc?gaa?ggc?atg?gac?cca?gac?cgc?gat?atc?acc?ctg?tac?atc?aac 307

Val?Leu?Glu?Gly?Met?Asp?Pro?Asp?Arg?Asp?Ile?Thr?Leu?Tyr?Ile?Asn

55 60 65

tca?cct?ggt?gga?tcc?ttc?acc?gcg?ttg?atg?gca?att?tac?gac?acc?atg 355

Ser?Pro?Gly?Gly?Ser?Phe?Thr?Ala?Leu?Met?Ala?Ile?Tyr?Asp?Thr?Met

70 75 80 85

cag?tac?gtc?cgc?cca?gac?gtt?cag?acc?gtc?tgc?ctt?ggt?cag?gca?gca 403

Gln?Tyr?Val?Arg?Pro?Asp?Val?Gln?Thr?Val?Cys?Leu?Gly?Gln?Ala?Ala

90 95 100

tcc?gca?gcc?gca?gtt?ctt?ctt?gca?gcc?ggt?gca?cca?ggt?aag?cgc?gct 451

Ser?Ala?Ala?Ala?Val?Leu?Leu?Ala?Ala?Gly?Ala?Pro?Gly?Lys?Arg?Ala

105 110 115

gtt?ctt?cct?aac?tcc?cgc?gtg?ctg?atc?cac?cag?cca?gca?acc?cag?ggc 499

Val?Leu?Pro?Asn?Ser?Arg?Val?Leu?Ile?His?Gln?Pro?Ala?Thr?Gln?Gly

120 125 130

acc?cag?ggt?cag?gtt?tct?gac?ctc?gag?atc?cag?gca?gct?gaa?atc?gag 547

Thr?Gln?Gly?Gln?Val?Ser?Asp?Leu?Glu?Ile?Gln?Ala?Ala?Glu?Ile?Glu

135 140 145

cgc?atg?cgt?cgt?ttg?atg?gaa?acc?acc?ttg?gct?gag?cac?acc?ggc?aag 595

Arg?Met?Arg?Arg?Leu?Met?Glu?Thr?Thr?Leu?Ala?Glu?His?Thr?Gly?Lys

150 155 160 165

acc?gcg?gag?cag?atc?cgc?atc?gat?acc?gac?cgt?gac?aag?atc?ctc?acc 643

Thr?Ala?Glu?Gln?Ile?Arg?Ile?Asp?Thr?Asp?Arg?Asp?Lys?Ile?Leu?Thr

170 175 180

gct?gag?gaa?gca?ctc?gag?tat?ggc?atc?gtt?gac?cag?gtc?ttc?gat?tac 691

Ala?Glu?Glu?Ala?Leu?Glu?Tyr?Gly?Ile?Val?Asp?Gln?Val?Phe?Asp?Tyr

185 190 195

cgc?aag?ctc?aag?cgc?tagagttttt?taaagattcg?ggt 729

Arg?Lys?Leu?Lys?Arg

200

<210>62

<211>202

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>62

Met?Pro?Thr?Ser?Arg?Tyr?Val?Leu?Pro?Ser?Phe?Ile?Glu?Gln?Ser?Ala

1 5 10 15

Tyr?Gly?Thr?Lys?Glu?Thr?Asn?Pro?Tyr?Ala?Lys?Leu?Phe?Glu?Glu?Arg

20 25 30

Ile?Ile?Phe?Leu?Gly?Thr?Gln?Val?Asp?Asp?Thr?Ser?Ala?Asn?Asp?Ile

35 40 45

Met?Ala?Gln?Leu?Leu?Val?Leu?Glu?Gly?Met?Asp?Pro?Asp?Arg?Asp?Ile

50 55 60

Thr?Leu?Tyr?Ile?Asn?Ser?Pro?GIy?Gly?Ser?Phe?Thr?Ala?Leu?Met?Ala

65 70 75 80

Ile?Tyr?Asp?Thr?Met?Gln?Tyr?Val?Arg?Pro?Asp?Val?Gln?Thr?Val?Cys

85 90 95

Leu?Gly?Gln?Ala?Ala?Ser?Ala?Ala?Ala?Val?Leu?Leu?Ala?Ala?Gly?Ala

100 105 110

Pro?Gly?Lys?Arg?Ala?Val?Leu?Pro?Asn?Ser?Arg?Val?Leu?Ile?His?Gln

115 120 125

Pro?Ala?Thr?Gln?Gly?Thr?Gln?Gly?Gln?Val?Ser?Asp?Leu?Glu?Ile?Gln

130 135 140

Ala?Ala?Glu?Ile?Glu?Arg?Met?Arg?Arg?Leu?Met?Glu?Thr?Thr?Leu?Ala

145 150 155 160

Glu?His?Thr?Gly?Lys?Thr?Ala?Glu?Gln?Ile?Arg?Ile?Asp?Thr?Asp?Arg

165 170 175

Asp?Lys?Ile?Leu?Thr?Ala?Glu?Glu?Ala?Leu?Glu?Tyr?Gly?Ile?Val?Asp

180 185 190

Gln?Val?Phe?Asp?Tyr?Arg?Lys?Leu?Lys?Arg

195 200

<210>63

<211>714

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(691)

<223>RXA00567

<400>63

cgaacagagg?cggtttcatg?gaaataccgc?cgggtagtct?ggtgacattg?aaccaaatga?60

acgtacccaa?gatttaagaa?tgtaggagtt?gactgttttc?atg?agc?gat?att?cgt 115

Met?Ser?Asp?Ile?Arg

1 5

atg?gca?gcc?cag?ggt?ggg?cct?ggt?ttc?gga?aat?gac?gtc?ttt?gat?cgc 163

Met?Ala?Ala?Gln?Gly?Gly?Pro?Gly?Phe?Gly?Asn?Asp?Val?Phe?Asp?Arg

10 15 20

ctc?atg?agt?gag?cgc?atc?att?ttc?ctg?gga?agc?cag?gta?gac?gat?gag 211

Leu?Met?Ser?Glu?Arg?Ile?Ile?Phe?Leu?Gly?Ser?Gln?Val?Asp?Asp?Glu

25 30 35

att?gca?aac?aag?cta?tgc?gct?cag?atc?ctg?ctg?ctg?tcc?gct?gag?gat 259

Ile?Ala?Asn?Lys?Leu?Cys?Ala?Gln?Ile?Leu?Leu?Leu?Ser?Ala?Glu?Asp

40 45 50

cca?acc?agg?gac?atc?tcc?ctg?tac?att?aac?tcc?cca?ggt?ggc?tcc?gtc 307

Pro?Thr?Arg?Asp?Ile?Ser?Leu?Tyr?Ile?Asn?Ser?Pro?Gly?Gly?Ser?Val

55 60 65

acc?gca?ggc?atg?gca?att?tat?gac?acc?atg?aaa?tac?tcc?cca?tgc?gac 355

Thr?Ala?Gly?Met?Ala?Ile?Tyr?Asp?Thr?Met?Lys?Tyr?Ser?Pro?Cys?Asp

70 75 80 85

atc?gca?acc?tac?ggc?atg?ggc?ctg?gca?gca?tcc?atg?ggc?cag?ttc?ctg 403

Ile?Ala?Thr?Tyr?Gly?Met?Gly?Leu?Ala?Ala?Ser?Met?Gly?Gln?Phe?Leu

90 95 100

ctt?tcc?ggt?ggc?act?aag?ggc?aag?cgt?ttc?gca?ttg?cca?cac?gca?cgt 451

Leu?Ser?Gly?Gly?Thr?Lys?Gly?Lys?Arg?Phe?Ala?Leu?Pro?His?Ala?Arg

105 110 115

atc?atg?atg?cac?cag?cct?tcc?gct?ggt?gtt?ggt?ggt?acc?gca?gct?gat 499

Ile?Met?Met?His?Gln?Pro?Ser?Ala?Gly?Val?Gly?Gly?Thr?Ala?Ala?Asp

120 125 130

atc?gct?atc?cag?gct?gag?cag?ttc?gca?gcc?acc?aag?cgt?gaa?atg?gcc 547

Ile?Ala?Ile?Gln?Ala?Glu?Gln?Phe?Ala?Ala?Thr?Lys?Arg?Glu?Met?Ala

135 140 145

cag?ctg?atc?gct?gag?cac?acc?ggc?cag?acc?ttt?gag?cag?atc?tcc?aag 595

Gln?Leu?Ile?Ala?Glu?His?Thr?Gly?Gln?Thr?Phe?Glu?Gln?Ile?Ser?Lys

150 155 160 165

gat?tcc?gat?cgt?gac?cgc?tgg?ttc?act?gca?cag?gaa?gct?aag?gat?tac 643

Asp?Ser?Asp?Arg?Asp?Arg?Trp?Phe?Thr?Ala?Gln?Glu?Ala?Lys?Asp?Tyr

170 175 180

gga?ctt?gtt?gac?cac?gtg?att?acc?ttg?gct?gaa?ggc?cca?atc?agc?aac 691

Gly?Leu?Val?Asp?His?Val?Ile?Thr?Leu?Ala?Glu?Gly?Pro?Ile?Ser?Asn

185 190 195

taggcgcacg?gaaaacttta?aag 714

<210>64

<211>197

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>64

Met?Ser?Asp?Ile?Arg?Met?Ala?Ala?Gln?Gly?Gly?Pro?Gly?Phe?Gly?Asn

1 5 10 15

Asp?Val?Phe?Asp?Arg?Leu?Met?Ser?Glu?Arg?Ile?Ile?Phe?Leu?Gly?Ser

20 25 30

Gln?Val?Asp?Asp?Glu?Ile?Ala?Asn?Lys?Leu?Cys?Ala?Gln?Ile?Leu?Leu

35 40 45

Leu?Ser?Ala?Glu?Asp?Pro?Thr?Arg?Asp?Ile?Ser?Leu?Tyr?Ile?Asn?Ser

50 55 60

Pro?Gly?Gly?Ser?Val?Thr?Ala?Gly?Met?Ala?Ile?Tyr?Asp?Thr?Met?Lys

65 70 75 80

Tyr?Ser?Pro?Cys?Asp?Ile?Ala?Thr?Tyr?Gly?Met?Gly?Leu?Ala?Ala?Ser

85 90 95

Met?Gly?Gln?Phe?Leu?Leu?Ser?Gly?Gly?Thr?Lys?Gly?Lys?Arg?Phe?Ala

100 105 110

Leu?Pro?His?Ala?Arg?Ile?Met?Met?His?Gln?Pro?Ser?Ala?Gly?Val?Gly

115 120 125

Gly?Thr?Ala?Ala?Asp?Ile?Ala?Ile?Gln?Ala?Glu?Gln?Phe?Ala?Ala?Thr

130 135 140

Lys?Arg?Glu?Met?Ala?Gln?Leu?Ile?Ala?Glu?His?Thr?Gly?Gln?Thr?Phe

145 150 155 160

Glu?Gln?Ile?Ser?Lys?Asp?Ser?Asp?Arg?Asp?Arg?Trp?Phe?Thr?Ala?Gln

165 170 175

Glu?Ala?Lys?Asp?Tyr?Gly?Leu?Val?Asp?His?Val?Ile?Thr?Leu?Ala?Glu

180 185 190

Gly?Pro?Ile?Ser?Asn

195

<210>65

<211>1875

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1852)

<223>RXN03094

<400>65

atagatatta?gagagttaaa?taatggcgct?tgacctgcag?gaaattgaga?tcaacactga?60

ttgtgtaggt?tggcgcccaa?caaagaaagg?gcgttgaaag?atg?agt?tca?ttc?aat 115

Met?Ser?Ser?Phe?Asn

1 5

cca?act?acc?aaa?acc?aat?gaa?gcc?atg?cag?gct?gct?ctt?cag?cag?gca 163

Pro?Thr?Thr?Lys?Thr?Asn?Glu?Ala?Met?Gln?Ala?Ala?Leu?Gln?Gln?Ala

10 15 20

tcc?tcg?gct?ggc?aac?cct?gat?att?cgt?cca?gct?cac?ctg?ttg?gct?gcc 211

Ser?Ser?Ala?Gly?Asn?Pro?Asp?Ile?Arg?Pro?Ala?His?Leu?Leu?Ala?Ala

25 30 35

atc?ttg?gag?caa?act?gat?ggc?gta?gca?gcg?cca?gtc?ctc?atg?gct?act 259

Ile?Leu?Glu?Gln?Thr?Asp?Gly?Val?Ala?Ala?Pro?Val?Leu?Met?Ala?Thr

40 45 50

ggt?gtg?gat?cct?aag?gag?atc?ctc?gca?gag?gcc?aag?aag?ttg?gtt?gct 307

Gly?Val?Asp?Pro?Lys?Glu?Ile?Leu?Ala?Glu?Ala?Lys?Lys?Leu?Val?Ala

55 60 65

tct?tac?ccc?aag?gct?tct?ggc?gcc?aat?atg?gct?aat?cca?aac?ttc?aac 355

Ser?Tyr?Pro?Lys?Ala?Ser?Gly?Ala?Asn?Met?Ala?Asn?Pro?Asn?Phe?Asn

70 75 80 85

cgg?gat?gcc?ctc?aat?gcg?ttc?act?gca?gct?cag?gag?ctt?gcc?ggt?gag 403

Arg?Asp?Ala?Leu?Asn?Ala?Phe?Thr?Ala?Ala?Gln?Glu?Leu?Ala?Gly?Glu

90 95 100

ttg?ggc?gat?gag?tac?gtc?tca?acc?gaa?gta?ctt?ctt?gcc?ggt?atc?gct 451

Leu?Gly?Asp?Glu?Tyr?Val?Ser?Thr?Glu?Val?Leu?Leu?Ala?Gly?Ile?Ala

105 110 115

cgc?gga?aag?tct?gat?gct?gcg?gat?ctg?ttg?acc?aac?aag?ggt?gca?acc 499

Arg?Gly?Lys?Ser?Asp?Ala?Ala?Asp?Leu?Leu?Thr?Asn?Lys?Gly?Ala?Thr

120 125 130

tat?gac?gcc?atc?aaa?gag?gct?ttc?cct?tcg?gtt?cgt?gga?tct?cag?cgt 547

Tyr?Asp?Ala?Ile?Lys?Glu?Ala?Phe?Pro?Ser?Val?Arg?Gly?Ser?Gln?Arg

135 140 145

gtc?acc?act?cag?gat?cca?gag?gga?cag?ttc?cag?gct?ttg?gaa?aag?tac 595

Val?Thr?Thr?Gln?Asp?Pro?Glu?Gly?Gln?Phe?Gln?Ala?Leu?Glu?Lys?Tyr

150 155 160 165

tcc?act?gac?ctg?acc?aag?ctt?gct?cgt?gaa?ggc?aag?att?gat?cct?gtt 643

Ser?Thr?Asp?Leu?Thr?Lys?Leu?Ala?Arg?Glu?Gly?Lys?Ile?Asp?Pro?Val

170 175 180

att?ggc?cgt?gac?cag?gaa?att?cgt?cgc?gtc?gtt?cag?gtg?ctt?agc?cgt 691

Ile?Gly?Arg?Asp?Gln?Glu?Ile?Arg?Arg?Val?Val?Gln?Val?Leu?Ser?Arg

185 190 195

cgt?acc?aag?aac?aac?cct?gtt?ctg?atc?ggt?gag?cca?ggt?gtc?ggt?aaa 739

Arg?Thr?Lys?Asn?Asn?Pro?Val?Leu?Ile?Gly?Glu?Pro?Gly?Val?Gly?Lys

200 205 210

acc?gcc?atc?gtg?gaa?ggc?ctt?gca?cgc?cgc?atc?gtt?gct?ggt?gac?gtt 787

Thr?Ala?Ile?Val?Glu?Gly?Leu?Ala?Arg?Arg?Ile?Val?Ala?Gly?Asp?Val

215 220 225

cca?gaa?tcc?ctc?aag?ggc?aaa?act?ctg?atc?agt?ctt?gat?ctt?ggt?tcc 835

Pro?Glu?Ser?Leu?Lys?Gly?Lys?Thr?Leu?Ile?Ser?Leu?Asp?Leu?Gly?Ser

230 235 240 245

atg?gtt?gcc?ggc?gct?aag?tat?cgc?ggt?gaa?ttc?gag?gag?cga?ctg?aag 883

Met?Val?Ala?Gly?Ala?Lys?Tyr?Arg?Gly?Glu?Phe?Glu?Glu?Arg?Leu?Lys

250 255 260

gct?gtt?ctg?gat?gag?atc?aag?gga?gct?aac?ggc?gaa?gtc?gtt?acc?ttc 931

Ala?Val?Leu?Asp?Glu?Ile?Lys?Gly?Ala?Asn?Gly?Glu?Val?Val?Thr?Phe

265 270 275

atc?gat?gag?ctg?cac?acc?atc?gtc?ggc?gct?ggt?gct?tcg?ggt?gaa?tcc 979

Ile?Asp?Glu?Leu?His?Thr?Ile?Val?Gly?Ala?Gly?Ala?Ser?Gly?Glu?Ser

280 285 290

gcc?atg?gat?gcc?gga?aac?atg?att?aag?cca?ctg?ctt?gcc?cgc?ggt?gag 1027

Ala?Met?Asp?Ala?Gly?Asn?Met?Ile?Lys?Pro?Leu?Leu?Ala?Arg?Gly?Glu

295 300 305

ctg?cgc?ttg?gtt?ggt?gcc?acc?acg?ctg?aat?gag?tac?cgc?aag?tac?atc 1075

Leu?Arg?Leu?Val?Gly?Ala?Thr?Thr?Leu?Asn?Glu?Tyr?Arg?Lys?Tyr?Ile

310 315 320 325

gaa?aag?gac?gct?gcc?ctg?gag?cgt?agg?ttc?cag?cag?gtt?tat?gtc?ggt 1123

Glu?Lys?Asp?Ala?Ala?Leu?Glu?Arg?Arg?Phe?Gln?Gln?Val?Tyr?Val?Gly

330 335 340

gag?cca?acg?gta?gaa?gat?gcc?atc?ggt?att?ctt?cgt?gga?ttg?aag?gaa 1171

Glu?Pro?Thr?Val?Glu?Asp?Ala?Ile?Gly?Ile?Leu?Arg?Gly?Leu?Lys?Glu

345 350 355

cgc?tac?gag?gtc?cat?cac?ggt?gtc?cgc?atc?cag?gac?tcc?gca?ctg?gtc 1219

Arg?Tyr?Glu?Val?His?His?Gly?Val?Arg?Ile?Gln?Asp?Ser?Ala?Leu?Val

360 365 370

gcc?gca?gct?gaa?ctc?tca?aac?cgc?tat?atc?acc?agc?cgt?ttc?ctt?cct 1267

Ala?Ala?Ala?Glu?Leu?Ser?Asn?Arg?Tyr?Ile?Thr?Ser?Arg?Phe?Leu?Pro

375 380 385

gat?aag?gct?att?gac?tta?gtt?gat?gag?gca?gca?tca?cgc?ctg?cgc?atg 1315

Asp?Lys?Ala?Ile?Asp?Leu?Val?Asp?Glu?Ala?Ala?Ser?Arg?Leu?Arg?Met

390 395 400 405

gag?att?gat?tct?tca?cct?cag?gaa?atc?gat?gag?ctg?gag?cgt?atc?gtc 1363

Glu?Ile?Asp?Ser?Ser?Pro?Gln?Glu?Ile?Asp?Glu?Leu?Glu?Arg?Ile?Val

410 415 420

cgc?cgc?ctc?gag?atc?gaa?gag?atg?gcg?ctg?tcc?aag?gaa?tcc?gat?gca 1411

Arg?Arg?Leu?Glu?Ile?Glu?Glu?Met?Ala?Leu?Ser?Lys?Glu?Ser?Asp?Ala

425 430 435

gct?tcc?aag?gaa?cgt?cta?gaa?aag?ctg?cgc?tcg?gaa?ctt?gct?gat?gaa 1459

Ala?Ser?Lys?Glu?Arg?Leu?Glu?Lys?Leu?Arg?Ser?Glu?Leu?Ala?Asp?Glu

440 445 450

cgc?gaa?aag?ctc?tct?gag?ttg?aag?gct?cgt?tgg?cag?aat?gag?aaa?act 1507

Arg?Glu?Lys?Leu?Ser?Glu?Leu?Lys?Ala?Arg?Trp?Gln?Asn?Glu?Lys?Thr

455 460 465

gct?att?gac?gat?gtc?cgg?gag?atg?aaa?gaa?gag?ctg?gaa?gcg?ctg?cgt 1555

Ala?Ile?Asp?Asp?Val?Arg?Glu?Met?Lys?Glu?Glu?Leu?Glu?Ala?Leu?Arg

470 475 480 485

tct?gag?tcg?gat?att?gca?aaa?cgt?gac?ggc?aat?tat?tgt?cgt?gtc?gca 1603

Ser?Glu?Ser?Asp?Ile?Ala?Lys?Arg?Asp?Gly?Asn?Tyr?Cys?Arg?Val?Ala

490 495 500

aag?ctt?cgc?tac?ggc?cga?atc?cct?gag?ctg?gaa?aag?cag?atc?gag?gat 1651

Lys?Leu?Arg?Tyr?Gly?Arg?Ile?Pro?Glu?Leu?Glu?Lys?Gln?Ile?Glu?Asp

505 510 515

gca?gaa?tcc?aag?gtc?gag?gtc?aat?gaa?aat?gcc?atg?ctc?act?gag?gag 1699

Ala?Glu?Ser?Lys?Val?Glu?Val?Asn?Glu?Asn?Ala?Met?Leu?Thr?Glu?Glu

520 525 530

gtc?acg?cca?gac?acg?atc?gcc?gat?gtg?gtt?tcc?gca?tgg?acg?ggc?att 1747

Val?Thr?Pro?Asp?Thr?Ile?Ala?Asp?Val?Val?Ser?Ala?Trp?Thr?Gly?Ile

535 540 545

cct?gca?ggc?aag?atg?atg?cag?ggt?gag?acc?gag?aag?ctg?ctc?aac?atg 1795

Pro?Ala?Gly?Lys?Met?Met?Gln?Gly?Glu?Thr?Glu?Lys?Leu?Leu?Asn?Met

550 555 560 565

gag?cgc?gtc?ttg?ggc?aac?cgt?gtg?gtc?ggt?cag?cta?gaa?agc?ggt?aac 1843

Glu?Arg?Val?Leu?Gly?Asn?Arg?Val?Val?Gly?Gln?Leu?Glu?Ser?Gly?Asn

570 575 580

tgc?agt?gtc?tgacgcggtg?cgtcgttcac?gcg 1875

Cys?Ser?Val

<210>66

<211>584

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>66

Met?Ser?Ser?Phe?Asn?Pro?Thr?Thr?Lys?Thr?Asn?Glu?Ala?Met?Gln?Ala

1 5 10 15

Ala?Leu?Gln?Gln?Ala?Ser?Ser?Ala?Gly?Asn?Pro?Asp?Ile?Arg?Pro?Ala

20 25 30

His?Leu?Leu?Ala?Ala?Ile?Leu?Glu?Gln?Thr?Asp?Gly?Val?Ala?Ala?Pro

35 40 45

Val?Leu?Met?Ala?Thr?Gly?Val?Asp?Pro?Lys?Glu?Ile?Leu?Ala?Glu?Ala

50 55 60

Lys?Lys?Leu?Val?Ala?Ser?Tyr?Pro?Lys?Ala?Ser?Gly?Ala?Asn?Met?Ala

65 70 75 80

Asn?Pro?Asn?Phe?Asn?Arg?Asp?Ala?Leu?Asn?Ala?Phe?Thr?Ala?Ala?Gln

85 90 95

Glu?Leu?Ala?Gly?Glu?Leu?Gly?Asp?Glu?Tyr?Val?Ser?Thr?Glu?Val?Leu

100 105 110

Leu?Ala?Gly?Ile?Ala?Arg?Gly?Lys?Ser?Asp?Ala?Ala?Asp?Leu?Leu?Thr

115 120 125

Asn?Lys?Gly?Ala?Thr?Tyr?Asp?Ala?Ile?Lys?Glu?Ala?Phe?Pro?Ser?Val

130 135 140

Arg?Gly?Ser?Gln?Arg?Val?Thr?Thr?Gln?Asp?Pro?Glu?Gly?Gln?Phe?Gln

145 150 155 160

Ala?Leu?Glu?Lys?Tyr?Ser?Thr?Asp?Leu?Thr?Lys?Leu?Ala?Arg?Glu?Gly

165 170 175

Lys?Ile?Asp?Pro?Val?Ile?Gly?Arg?Asp?Gln?Glu?Ile?Arg?Arg?Val?Val

180 185 190

Gln?Val?Leu?Ser?Arg?Arg?Thr?Lys?Asn?Asn?Pro?Val?Leu?Ile?Gly?Glu

195 200 205

Pro?Gly?Val?Gly?Lys?Thr?Ala?Ile?Val?Glu?Gly?Leu?Ala?Arg?Arg?Ile

210 215 220

Val?Ala?Gly?Asp?Val?Pro?Glu?Ser?Leu?Lys?Gly?Lys?Thr?Leu?Ile?Ser

225 230 235 240

Leu?Asp?Leu?Gly?Ser?Met?Val?Ala?Gly?Ala?Lys?Tyr?Arg?Gly?Glu?Phe

245 250 255

Glu?Glu?Arg?Leu?Lys?Ala?Val?Leu?Asp?Glu?Ile?Lys?Gly?Ala?Asn?Gly

260 265 270

Glu?Val?Val?Thr?Phe?Ile?Asp?Glu?Leu?His?Thr?Ile?Val?Gly?Ala?Gly

275 280 285

Ala?Ser?Gly?Glu?Ser?Ala?Met?Asp?Ala?Gly?Asn?Met?Ile?Lys?Pro?Leu

290 295 300

Leu?Ala?Arg?Gly?Glu?Leu?Arg?Leu?Val?Gly?Ala?Thr?Thr?Leu?Asn?Glu

305 310 315 320

Tyr?Arg?Lys?Tyr?Ile?Glu?Lys?Asp?Ala?Ala?Leu?Glu?Arg?Arg?Phe?Gln

325 330 335

Gln?Val?Tyr?Val?Gly?Glu?Pro?Thr?Val?Glu?Asp?Ala?Ile?Gly?Ile?Leu

340 345 350

Arg?Gly?Leu?Lys?Glu?Arg?Tyr?Glu?Val?His?His?Gly?Val?Arg?Ile?Gln

355 360 365

Asp?Ser?Ala?Leu?Val?Ala?Ala?Ala?Glu?Leu?Ser?Asn?Arg?Tyr?Ile?Thr

370 375 380

Ser?Arg?Phe?Leu?Pro?Asp?Lys?Ala?Ile?Asp?Leu?Val?Asp?Glu?Ala?Ala

385 390 395 400

Ser?Arg?Leu?Arg?Met?Glu?Ile?Asp?Ser?Ser?Pro?Gln?Glu?Ile?Asp?Glu

405 410 415

Leu?Glu?Arg?Ile?Val?Arg?Arg?Leu?Glu?Ile?Glu?Glu?Met?Ala?Leu?Ser

420 425 430

Lys?Glu?Ser?Asp?Ala?Ala?Ser?Lys?Glu?Arg?Leu?Glu?Lys?Leu?Arg?Ser

435 440 445

Glu?Leu?Ala?Asp?Glu?Arg?Glu?Lys?Leu?Ser?Glu?Leu?Lys?Ala?Arg?Trp

450 455 460

Gln?Asn?Glu?Lys?Thr?Ala?Ile?Asp?Asp?Val?Arg?Glu?Met?Lys?Glu?Glu

465 470 475 480

Leu?Glu?Ala?Leu?Arg?Ser?Glu?Ser?Asp?Ile?Ala?Lys?Arg?Asp?Gly?Asn

485 490 495

Tyr?Cys?Arg?Val?Ala?Lys?Leu?Arg?Tyr?Gly?Arg?Ile?Pro?Glu?Leu?Glu

500 505 510

Lys?Gln?Ile?Glu?Asp?Ala?Glu?Ser?Lys?Val?Glu?Val?Asn?Glu?Asn?Ala

515 520 525

Met?Leu?Thr?Glu?Glu?Val?Thr?Pro?Asp?Thr?Ile?Ala?Asp?Val?Val?Ser

530 535 540

Ala?Trp?Thr?Gly?Ile?Pro?Ala?Gly?Lys?Met?Met?Gln?Gly?Glu?Thr?Glu

545 550 555 560

Lys?Leu?Leu?Asn?Met?Glu?Arg?Val?Leu?Gly?Asn?Arg?Val?Val?Gly?Gln

565 570 575

Leu?Glu?Ser?Gly?Asn?Cys?Ser?Val

580

<210>67

<211>1816

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1816)

<223>FRXA01668

<400>67

atagatatta?gagagttaaa?taatggcgct?tgacctgcag?gaaattgaga?tcaacactga?60

ttgtgtaggt?tggcgcccaa?caaagaaagg?gcgttgaaag?atg?agt?tca?ttc?aat 115

Met?Ser?Ser?Phe?Asn

1 5

cca?act?acc?aaa?acc?aat?gaa?gcc?atg?cag?gct?gct?ctt?cag?cag?gca 163

Pro?Thr?Thr?Lys?Thr?Asn?Glu?Ala?Met?Gln?Ala?Ala?Leu?Gln?Gln?Ala

10 15 20

tcc?tcg?gct?ggc?aac?cct?gat?att?cgt?cca?gct?cac?ctg?ttg?gct?gcc 211

Ser?Ser?Ala?Gly?Asn?Pro?Asp?Ile?Arg?Pro?Ala?His?Leu?Leu?Ala?Ala

25 30 35

atc?ttg?gag?caa?act?gat?ggc?gta?gca?gcg?cca?gtc?ctc?atg?gct?act 259

Ile?Leu?Glu?Gln?Thr?Asp?Gly?Val?Ala?Ala?Pro?Val?Leu?Met?Ala?Thr

40 45 50

ggt?gtg?gat?cct?aag?gag?atc?ctc?gca?gag?gcc?aag?aag?ttg?gtt?gct 307

Gly?Val?Asp?Pro?Lys?Glu?Ile?Leu?Ala?Glu?Ala?Lys?Lys?Leu?Val?Ala

55 60 65

tct?tac?ccc?aag?gct?tct?ggc?gcc?aat?atg?gct?aat?cca?aac?ttc?aac 355

Ser?Tyr?Pro?Lys?Ala?Ser?Gly?Ala?Asn?Met?Ala?Asn?Pro?Asn?Phe?Asn

70 75 80 85

cgg?gat?gcc?ctc?aat?gcg?ttc?act?gca?gct?cag?gag?ctt?gcc?ggt?gag 403

Arg?Asp?Ala?Leu?Asn?Ala?Phe?Thr?Ala?Ala?Gln?Glu?Leu?Ala?Gly?Glu

90 95 100

ttg?ggc?gat?gag?tac?gtc?tca?acc?gaa?gta?ctt?ctt?gcc?ggt?atc?gct 451

Leu?Gly?Asp?Glu?Tyr?Val?Ser?Thr?Glu?Val?Leu?Leu?Ala?Gly?Ile?Ala

105 110 115

cgc?gga?aag?tct?gat?gct?gcg?gat?ctg?ttg?acc?aac?aag?ggt?gca?acc 499

Arg?Gly?Lys?Ser?Asp?Ala?Ala?Asp?Leu?Leu?Thr?Asn?Lys?Gly?Ala?Thr

120 125 130

tat?gac?gcc?atc?aaa?gag?gct?ttc?cct?tcg?gtt?cgt?gga?tct?cag?cgt 547

Tyr?Asp?Ala?Ile?Lys?Glu?Ala?Phe?Pro?Ser?Val?Arg?Gly?Ser?Gln?Arg

135 140 145

gtc?acc?act?cag?gat?cca?gag?gga?cag?ttc?cag?gct?ttg?gaa?aag?tac 595

Val?Thr?Thr?Gln?Asp?Pro?Glu?Gly?Gln?Phe?Gln?Ala?Leu?Glu?Lys?Tyr

150 155 160 165

tcc?act?gac?ctg?acc?aag?ctt?gct?cgt?gaa?ggc?aag?att?gat?cct?gtt 643

Ser?Thr?Asp?Leu?Thr?Lys?Leu?Ala?Arg?Glu?Gly?Lys?Ile?Asp?Pro?Val

170 175 180

att?ggc?cgt?gac?cag?gaa?att?cgt?cgc?gtc?gtt?cag?gtg?ctt?agc?cgt 691

Ile?Gly?Arg?Asp?Gln?Glu?Ile?Arg?Arg?Val?Val?Gln?Val?Leu?Ser?Arg

185 190 195

cgt?acc?aag?aac?aac?cct?gtt?ctg?atc?ggt?gag?cca?ggt?gtc?ggt?aaa 739

Arg?Thr?Lys?Asn?Asn?Pro?Val?Leu?Ile?Gly?Glu?Pro?Gly?Val?Gly?Lys

200 205 210

acc?gcc?atc?gtg?gaa?ggc?ctt?gca?cgc?cgc?atc?gtt?gct?ggt?gac?gtt 787

Thr?Ala?Ile?Val?Glu?Gly?Leu?Ala?Arg?Arg?Ile?Val?Ala?Gly?Asp?Val

215 220 225

cca?gaa?tcc?ctc?aag?ggc?aaa?act?ctg?atc?agt?ctt?gat?ctt?ggt?tcc 835

Pro?Glu?Ser?Leu?Lys?Gly?Lys?Thr?Leu?Ile?Ser?Leu?Asp?Leu?Gly?Ser

230 235 240 245

atg?gtt?gcc?ggc?gct?aag?tat?cgc?ggt?gaa?ttc?gag?gag?cga?ctg?aag 883

Met?Val?Ala?Gly?Ala?Lys?Tyr?Arg?Gly?Glu?Phe?Glu?Glu?Arg?Leu?Lys

250 255 260

gct?gtt?ctg?gat?gag?atc?aag?gga?gct?aac?ggc?gaa?gtc?gtt?acc?ttc 931

Ala?Val?Leu?Asp?Glu?Ile?Lys?Gly?Ala?Asn?Gly?Glu?Val?Val?Thr?Phe

265 270 275

atc?gat?gag?ctg?cac?acc?atc?gtc?ggc?gct?ggt?gct?tcg?ggt?gaa?tcc 979

Ile?Asp?Glu?Leu?His?Thr?Ile?Val?Gly?Ala?Gly?Ala?Ser?Gly?Glu?Ser

280 285 290

gcc?atg?gat?gcc?gga?aac?atg?att?aag?cca?ctg?ctt?gcc?cgc?ggt?gag 1027

Ala?Met?Asp?Ala?Gly?Asn?Met?Ile?Lys?Pro?Leu?Leu?Ala?Arg?Gly?Glu

295 300 305

ctg?cgc?ttg?gtt?ggt?gcc?acc?acg?ctg?aat?gag?tac?cgc?aag?tac?atc 1075

Leu?Arg?Leu?Val?Gly?Ala?Thr?Thr?Leu?Asn?Glu?Tyr?Arg?Lys?Tyr?Ile

310 315 320 325

gaa?aag?gac?gct?gcc?ctg?gag?cgt?agg?ttc?cag?cag?gtt?tat?gtc?ggt 1123

Glu?Lys?Asp?Ala?Ala?Leu?Glu?Arg?Arg?Phe?Gln?Gln?Val?Tyr?Val?Gly

330 335 340

gag?cca?acg?gta?gaa?gat?gcc?atc?ggt?att?ctt?cgt?gga?ttg?aag?gaa 1171

Glu?Pro?Thr?Val?Glu?Asp?Ala?Ile?Gly?Ile?Leu?Arg?Gly?Leu?Lys?Glu

345 350 355

cgc?tac?gag?gtc?cat?cac?ggt?gtc?cgc?atc?cag?gac?tcc?gca?ctg?gtc 1219

Arg?Tyr?Glu?Val?His?His?Gly?Val?Arg?Ile?Gln?Asp?Ser?Ala?Leu?Val

360 365 370

gcc?gca?gct?gaa?ctc?tca?aac?cgc?tat?atc?acc?agc?cgt?ttc?ctt?cct 1267

Ala?Ala?Ala?Glu?Leu?Ser?Asn?Arg?Tyr?Ile?Thr?Ser?Arg?Phe?Leu?Pro

375 380 385

gat?aag?gct?att?gac?tta?gtt?gat?gag?gca?gca?tca?cgc?ctg?cgc?atg 1315

Asp?Lys?Ala?Ile?Asp?Leu?Val?Asp?Glu?Ala?Ala?Ser?Arg?Leu?Arg?Met

390 395 400 405

gag?att?gat?tct?tca?cct?cag?gaa?atc?gat?gag?ctg?gag?cgt?atc?gtc 1363

Glu?Ile?Asp?Ser?Ser?Pro?Gln?Glu?Ile?Asp?Glu?Leu?Glu?Arg?Ile?Val

410 415 420

cgc?cgc?ctc?gag?atc?gaa?gag?atg?gcg?ctg?tcc?aag?gaa?tcc?gat?gca 1411

Arg?Arg?Leu?Glu?Ile?Glu?Glu?Met?Ala?Leu?Ser?Lys?Glu?Ser?Asp?Ala

425 430 435

gct?tcc?aag?gaa?cgt?cta?gaa?aag?ctg?cgc?tcg?gaa?ctt?gct?gat?gaa 1459

Ala?Ser?Lys?Glu?Arg?Leu?Glu?Lys?Leu?Arg?Ser?Glu?Leu?Ala?Asp?Glu

440 445 450

cgc?gaa?aag?ctc?tct?gag?ttg?aag?gct?cgt?tgg?cag?aat?gag?aaa?act 1507

Arg?Glu?Lys?Leu?Ser?Glu?Leu?Lys?Ala?Arg?Trp?Gln?Asn?Glu?Lys?Thr

455 460 465

gct?att?gac?gat?gtc?cgg?gag?atg?aaa?gaa?gag?ctg?gaa?gcg?ctg?cgt 1555

Ala?Ile?Asp?Asp?Val?Arg?Glu?Met?Lys?Glu?Glu?Leu?Glu?Ala?Leu?Arg

470 475 480 485

tct?gag?tcg?gat?att?gca?aaa?cgt?gac?ggc?aat?tat?tgt?cgt?gtc?gca 1603

Ser?Glu?Ser?Asp?Ile?Ala?Lys?Arg?Asp?Gly?Asn?Tyr?Cys?Arg?Val?Ala

490 495 500

aag?ctt?cgc?tac?ggc?cga?atc?cct?gag?ctg?gaa?aag?cag?atc?gag?gat 1651

Lys?Leu?Arg?Tyr?Gly?Arg?Ile?Pro?Glu?Leu?Glu?Lys?Gln?Ile?Glu?Asp

505 510 515

gca?gaa?tcc?aag?gtc?gag?gtc?aat?gaa?aat?gcc?atg?ctc?act?gag?gag 1699

Ala?Glu?Ser?Lys?Val?Glu?Val?Asn?Glu?Asn?Ala?Met?Leu?Thr?Glu?Glu

520 525 530

gtc?acg?cca?gac?acg?atc?gcc?gat?gtg?gtt?tcc?gca?tgg?acg?ggc?att 1747

Val?Thr?Pro?Asp?Thr?Ile?Ala?Asp?Val?Val?Ser?Ala?Trp?Thr?Gly?Ile

535 540 545

cct?gca?ggc?aag?atg?atg?cag?ggt?gag?acc?gag?aag?ctg?ctc?aac?atg 1795

Pro?Ala?Gly?Lys?Met?Met?Gln?Gly?Glu?Thr?Glu?Lys?Leu?Leu?Asn?Met

550 555 560 565

gag?cgc?gtc?ttg?ggc?aac?ccg 1816

Glu?Arg?Val?Leu?Gly?Asn?Pro

570

<210>68

<211>572

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>68

Met?Ser?Ser?Phe?Asn?Pro?Thr?Thr?Lys?Thr?Asn?Glu?Ala?Met?Gln?Ala

1 5 10 15

Ala?Leu?Gln?Gln?Ala?Ser?Ser?Ala?Gly?Asn?Pro?Asp?Ile?Arg?Pro?Ala

20 25 30

His?Leu?Leu?Ala?Ala?Ile?Leu?Glu?Gln?Thr?Asp?Gly?Val?Ala?Ala?Pro

35 40 45

Val?Leu?Met?Ala?Thr?Gly?Val?Asp?Pro?Lys?Glu?Ile?Leu?Ala?Glu?Ala

50 55 60

Lys?Lys?Leu?Val?Ala?Ser?Tyr?Pro?Lys?Ala?Ser?Gly?Ala?Asn?Met?Ala

65 70 75 80

Asn?Pro?Asn?Phe?Asn?Arg?Asp?Ala?Leu?Asn?Ala?Phe?Thr?Ala?Ala?Gln

85 90 95

Glu?Leu?Ala?Gly?Glu?Leu?Gly?Asp?Glu?Tyr?Val?Ser?Thr?Glu?Val?Leu

100 105 110

Leu?Ala?Gly?Ile?Ala?Arg?Gly?Lys?Ser?Asp?Ala?Ala?Asp?Leu?Leu?Thr

115 120 125

Asn?Lys?Gly?Ala?Thr?Tyr?Asp?Ala?Ile?Lys?Glu?Ala?Phe?Pro?Ser?Val

130 135 140

Arg?Gly?Ser?Gln?Arg?Val?Thr?Thr?Gln?Asp?Pro?Glu?Gly?Gln?Phe?Gln

145 150 155 160

Ala?Leu?Glu?Lys?Tyr?Ser?Thr?Asp?Leu?Thr?Lys?Leu?Ala?Arg?Glu?Gly

165 170 175

Lys?Ile?Asp?Pro?Val?Ile?Gly?Arg?Asp?Gln?Glu?Ile?Arg?Arg?Val?Val

180 185 190

Gln?Val?Leu?Ser?Arg?Arg?Thr?Lys?Asn?Asn?Pro?Val?Leu?Ile?Gly?Glu

195 200 205

Pro?Gly?Val?Gly?Lys?Thr?Ala?Ile?Val?Glu?Gly?Leu?Ala?Arg?Arg?Ile

210 215 220

Val?Ala?Gly?Asp?Val?Pro?Glu?Ser?Leu?Lys?Gly?Lys?Thr?Leu?Ile?Ser

225 230 235 240

Leu?Asp?Leu?Gly?Ser?Met?Val?Ala?Gly?Ala?Lys?Tyr?Arg?Gly?Glu?Phe

245 250 255

Glu?Glu?Arg?Leu?Lys?Ala?Val?Leu?Asp?Glu?Ile?Lys?Gly?Ala?Asn?Gly

260 265 270

Glu?Val?Val?Thr?Phe?Ile?Asp?Glu?Leu?His?Thr?Ile?Val?Gly?Ala?Gly

275 280 285

Ala?Ser?Gly?Glu?Ser?Ala?Met?Asp?Ala?Gly?Asn?Met?Ile?Lys?Pro?Leu

290 295 300

Leu?Ala?Arg?Gly?Glu?Leu?Arg?Leu?Val?Gly?Ala?Thr?Thr?Leu?Asn?Glu

305 310 315 320

Tyr?Arg?Lys?Tyr?Ile?Glu?Lys?Asp?Ala?Ala?Leu?Glu?Arg?Arg?Phe?Gln

325 330 335

Gln?Val?Tyr?Val?Gly?Glu?Pro?Thr?Val?Glu?Asp?Ala?Ile?Gly?Ile?Leu

340 345 350

Arg?Gly?Leu?Lys?Glu?Arg?Tyr?Glu?Val?His?His?Gly?Val?Arg?Ile?Gln

355 360 365

Asp?Ser?Ala?Leu?Val?Ala?Ala?Ala?Glu?Leu?Ser?Asn?Arg?Tyr?Ile?Thr

370 375 380

Ser?Arg?Phe?Leu?Pro?Asp?Lys?Ala?Ile?Asp?Leu?Val?Asp?Glu?Ala?Ala

385 390 395 400

Ser?Arg?Leu?Arg?Met?Glu?Ile?Asp?Ser?Ser?Pro?Gln?Glu?Ile?Asp?Glu

405 410 415

Leu?Glu?Arg?Ile?Val?Arg?Arg?Leu?Glu?Ile?Glu?Glu?Met?Ala?Leu?Ser

420 425 430

Lys?Glu?Ser?Asp?Ala?Ala?Ser?Lys?Glu?Arg?Leu?Glu?Lys?Leu?Arg?Ser

435 440 445

Glu?Leu?Ala?Asp?Glu?Arg?Glu?Lys?Leu?Ser?Glu?Leu?Lys?Ala?Arg?Trp

450 455 460

Gln?Asn?Glu?Lys?Thr?Ala?Ile?Asp?Asp?Val?Arg?Glu?Met?Lys?Glu?Glu

465 470 475 480

Leu?Glu?Ala?Leu?Arg?Ser?Glu?Ser?Asp?Ile?Ala?Lys?Arg?Asp?Gly?Asn

485 490 495

Tyr?Cys?Arg?Val?Ala?Lys?Leu?Arg?Tyr?Gly?Arg?Ile?Pro?Glu?Leu?Glu

500 505 510

Lys?Gln?Ile?Glu?Asp?Ala?Glu?Ser?Lys?Val?Glu?Val?Asn?Glu?Asn?Ala

515 520 525

Met?Leu?Thr?Glu?Glu?Val?Thr?Pro?Asp?Thr?Ile?Ala?Asp?Val?Val?Ser

530 535 540

Ala?Trp?Thr?Gly?Ile?Pro?Ala?Gly?Lys?Met?Met?Gln?Gly?Glu?Thr?Glu

545 550 555 560

Lys?Leu?Leu?Asn?Met?Glu?Arg?Val?Leu?Gly?Asn?Pro

565 570

<210>69

<211>1401

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1378)

<223>RXN01120

<400>69

acaggtaaag?cgctaagatg?gaacaaccca?ttgccaatat?tgttggttag?agttgtacgc?60

agtaaatctt?ttcaatcgtg?gaagcgggtc?tcacagtcta?atg?gca?cgt?atg?cag 115

Met?Ala?Arg?Met?Gln

1 5

gaa?agc?gcc?gat?ctg?ctc?aaa?tgt?tcc?ttc?tgc?gga?aag?agc?caa?aag 163

Glu?Ser?Ala?Asp?Leu?Leu?Lys?Cys?Ser?Phe?Cys?Gly?Lys?Ser?Gln?Lys

10 15 20

cag?gta?aaa?aaa?ctc?atc?gcg?ggt?ggc?gcc?gta?tat?atc?tgt?gat?gag 211

Gln?Val?Lys?Lys?Leu?Ile?Ala?Gly?Gly?Ala?Val?Tyr?Ile?Cys?Asp?Glu

25 30 35

tgc?att?gag?ctg?tgc?aac?gag?att?att?gaa?gaa?gaa?ctc?ggt?caa?gct 259

Cys?Ile?Glu?Leu?Cys?Asn?Glu?Ile?Ile?Glu?Glu?Glu?Leu?Gly?Gln?Ala

40 45 50

caa?cac?gac?gag?cag?gag?cgc?aac?gag?ctc?ccc?aag?ccg?tcg?gag?att 307

Gln?His?Asp?Glu?Gln?Glu?Arg?Asn?Glu?Leu?Pro?Lys?Pro?Ser?Glu?Ile

55 60 65

tca?gcc?ttc?ctt?gat?act?tat?gtc?atc?ggg?cag?gac?cca?gca?aaa?cgt 355

Ser?Ala?Phe?Leu?Asp?Thr?Tyr?Val?Ile?Gly?Gln?Asp?Pro?Ala?Lys?Arg

70 75 80 85

atc?ctg?tcg?gtt?gcg?gtg?tac?aac?cat?tac?aag?cgt?ctc?cgc?gca?tcg 403

Ile?Leu?Ser?Val?Ala?Val?Tyr?Asn?His?Tyr?Lys?Arg?Leu?Arg?Ala?Ser

90 95 100

gaa?acc?atc?ggt?cgt?cgc?agg?aat?gac?gag?cct?gaa?acc?gaa?ctg?gtt 451

Glu?Thr?Ile?Gly?Arg?Arg?Arg?Asn?Asp?Glu?Pro?Glu?Thr?Glu?Leu?Val

105 110 115

aag?tcc?aat?att?ttg?atg?ctc?ggc?ccc?act?ggc?tcc?ggc?aag?act?ttc 499

Lys?Ser?Asn?Ile?Leu?Met?Leu?Gly?Pro?Thr?Gly?Ser?Gly?Lys?Thr?Phe

120 125 130

ctt?gcc?cag?act?ttg?gca?aag?ctg?ctg?gat?gtt?cct?ttt?gct?atc?gcg 547

Leu?Ala?Gln?Thr?Leu?Ala?Lys?Leu?Leu?Asp?Val?Pro?Phe?Ala?Ile?Ala

135 140 145

gat?gcc?acc?tca?ctg?acc?gag?gct?ggt?tat?gtg?ggc?gag?gat?gtg?gaa 595

Asp?Ala?Thr?Ser?Leu?Thr?Glu?Ala?Gly?Tyr?Val?Gly?Glu?Asp?Val?Glu

150 155 160 165

aac?atc?ttg?ctc?aag?ctg?ctt?cag?gct?gct?gat?ttt?gat?gtg?gaa?cgt 643

Asn?Ile?Leu?Leu?Lys?Leu?Leu?Gln?Ala?Ala?Asp?Phe?Asp?Val?Glu?Arg

170 175 180

gca?cag?cgc?ggc?atc?att?tac?atc?gat?gaa?gtg?gac?aag?att?tcc?cgc 691

Ala?Gln?Arg?Gly?Ile?Ile?Tyr?Ile?Asp?Glu?Val?Asp?Lys?Ile?Ser?Arg

185 190 195

aag?tct?gaa?aac?cca?tcg?atc?act?cgc?gat?gtt?tcc?ggt?gaa?ggc?gtg 739

Lys?Ser?Glu?Asn?Pro?Ser?Ile?Thr?Arg?Asp?Val?Ser?Gly?Glu?Gly?Val

200 205 210

cag?cag?gca?ctg?ctg?aaa?att?ttg?gaa?ggc?act?gtc?gcc?gca?atc?cca 787

Gln?Gln?Ala?Leu?Leu?Lys?Ile?Leu?Glu?Gly?Thr?Val?Ala?Ala?Ile?Pro

215 220 225

ccg?cag?gga?gga?cgc?aag?cac?ccc?aac?cag?gat?ttc?atc?cag?ctg?gat 835

Pro?Gln?Gly?Gly?Arg?Lys?His?Pro?Asn?Gln?Asp?Phe?Ile?Gln?Leu?Asp

230 235 240 245

acc?acc?aac?att?ttg?ttc?atc?gtt?gct?ggt?gcg?ttc?tct?ggt?ctg?gag 883

Thr?Thr?Asn?Ile?Leu?Phe?Ile?Val?Ala?Gly?Ala?Phe?Ser?Gly?Leu?Glu

250 255 260

aag?gtc?atc?gcg?gac?cgc?aat?ggc?aag?aaa?ggc?ttg?ggc?ttc?ggt?gtg 931

Lys?Val?Ile?Ala?Asp?Arg?Asn?Gly?Lys?Lys?Gly?Leu?Gly?Phe?Gly?Val

265 270 275

gag?gtc?tct?tcc?aag?aag?gaa?gaa?gcc?aac?att?gtg?gat?atc?ttc?aag 979

Glu?Val?Ser?Ser?Lys?Lys?Glu?Glu?Ala?Asn?Ile?Val?Asp?Ile?Phe?Lys

280 285 290

gat?gtc?ctc?cct?gag?gac?ctg?gtg?aag?ttt?ggt?ctc?atc?cca?gaa?ttc 1027

Asp?Val?Leu?Pro?Glu?Asp?Leu?Val?Lys?Phe?Gly?Leu?Ile?Pro?Glu?Phe

295 300 305

att?ggg?cgt?ctg?cca?gtc?gtt?gcc?acc?gta?tcc?aac?ctg?gat?cag?aaa 1075

Ile?Gly?Arg?Leu?Pro?Val?Val?Ala?Thr?Val?Ser?Asn?Leu?Asp?Gln?Lys

310 315 320 325

tct?ctg?gtc?aag?gtt?ctc?acg?gag?cct?cgt?aac?tca?ttg?gtg?aag?cag 1123

Ser?Leu?Val?Lys?Val?Leu?Thr?Glu?Pro?Arg?Asn?Ser?Leu?Val?Lys?Gln

330 335 340

tat?cga?cgt?ctg?ttt?gaa?atg?gat?gac?gct?gtg?ttg?acc?ttt?act?gat 1171

Tyr?Arg?Arg?Leu?Phe?Glu?Met?Asp?Asp?Ala?Val?Leu?Thr?Phe?Thr?Asp

345 350 355

gat?gct?ttg?gag?gag?atc?gct?aat?cag?gca?ctc?gag?cgc?aaa?act?ggc 1219

Asp?Ala?Leu?Glu?Glu?Ile?Ala?Asn?Gln?Ala?Leu?Glu?Arg?Lys?Thr?Gly

360 365 370

gcc?cgt?ggc?ctg?cgc?gcg?atc?atg?gaa?gag?atc?ctg?gtt?ccg?atc?atg 1267

Ala?Arg?Gly?Leu?Arg?Ala?Ile?Met?Glu?Glu?Ile?Leu?Val?Pro?Ile?Met

375 380 385

tat?gac?ctc?cca?gac?cgt?aaa?gac?gtt?ggc?gaa?gtc?atc?atc?aac?ggt 1315

Tyr?Asp?Leu?Pro?Asp?Arg?Lys?Asp?Val?Gly?Glu?Val?Ile?Ile?Asn?Gly

390 395 400 405

gcc?gtt?gcc?cgt?ggc?gaa?gcc?gaa?cca?gag?atg?ttg?gaa?gct?gtc?gca 1363

Ala?Val?Ala?Arg?Gly?Glu?Ala?Glu?Pro?Glu?Met?Leu?Glu?Ala?Val?Ala

410 415 420

gaa?gaa?aag?acc?gcg?tagttggcag?gagttatcac?cgg 1401

Glu?Glu?Lys?Thr?Ala

425

<210>70

<211>426

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>70

Met?Ala?Arg?Met?Gln?Glu?Ser?Ala?Asp?Leu?Leu?Lys?Cys?Ser?Phe?Cys

1 5 10 15

Gly?Lys?Ser?Gln?Lys?Gln?Val?Lys?Lys?Leu?Ile?Ala?Gly?Gly?Ala?Val

20 25 30

Tyr?Ile?Cys?Asp?Glu?Cys?Ile?Glu?Leu?Cys?Asn?Glu?Ile?Ile?Glu?Glu

35 40 45

Glu?Leu?Gly?Gln?Ala?Gln?His?Asp?Glu?Gln?Glu?Arg?Asn?Glu?Leu?Pro

50 55 60

Lys?Pro?Ser?Glu?Ile?Ser?Ala?Phe?Leu?Asp?Thr?Tyr?Val?Ile?Gly?Gln

65 70 75 80

Asp?Pro?Ala?Lys?Arg?Ile?Leu?Ser?Val?Ala?Val?Tyr?Asn?His?Tyr?Lys

85 90 95

Arg?Leu?Arg?Ala?Ser?Glu?Thr?Ile?Gly?Arg?Arg?Arg?Asn?Asp?Glu?Pro

100 105 110

Glu?Thr?Glu?Leu?Val?Lys?Ser?Asn?Ile?Leu?Met?Leu?Gly?Pro?Thr?Gly

115 120 125

Ser?Gly?Lys?Thr?Phe?Leu?Ala?Gln?Thr?Leu?Ala?Lys?Leu?Leu?Asp?Val

130 135 140

Pro?Phe?Ala?Ile?Ala?Asp?Ala?Thr?Ser?Leu?Thr?Glu?Ala?Gly?Tyr?Val

145 150 155 160

Gly?Glu?Asp?Val?Glu?Asn?Ile?Leu?Leu?Lys?Leu?Leu?Gln?Ala?Ala?Asp

165 170 175

Phe?Asp?Val?Glu?Arg?Ala?Gln?Arg?Gly?Ile?Ile?Tyr?Ile?Asp?Glu?Val

180 185 190

Asp?Lys?Ile?Ser?Arg?Lys?Ser?Glu?Asn?Pro?Ser?Ile?Thr?Arg?Asp?Val

195 200 205

Ser?Gly?Glu?Gly?Val?Gln?Gln?Ala?Leu?Leu?Lys?Ile?Leu?Glu?Gly?Thr

210 215 220

Val?Ala?Ala?Ile?Pro?Pro?Gln?Gly?Gly?Arg?Lys?His?Pro?Asn?Gln?Asp

225 230 235 240

Phe?Ile?Gln?Leu?Asp?Thr?Thr?Asn?Ile?Leu?Phe?Ile?Val?Ala?Gly?Ala

245 250 255

Phe?Ser?Gly?Leu?Glu?Lys?Val?Ile?Ala?Asp?Arg?Asn?Gly?Lys?Lys?Gly

260 265 270

Leu?Gly?Phe?Gly?Val?Glu?Val?Ser?Ser?Lys?Lys?Glu?Glu?Ala?Asn?Ile

275 280 285

Val?Asp?Ile?Phe?Lys?Asp?Val?Leu?Pro?Glu?Asp?Leu?Val?Lys?Phe?Gly

290 295 300

Leu?Ile?Pro?Glu?Phe?Ile?Gly?Arg?Leu?Pro?Val?Val?Ala?Thr?Val?Ser

305 310 315 320

Asn?Leu?Asp?Gln?Lys?Ser?Leu?Val?Lys?Val?Leu?Thr?Glu?Pro?Arg?Asn

325 330 335

Ser?Leu?Val?Lys?Gln?Tyr?Arg?Arg?Leu?Phe?Glu?Met?Asp?Asp?Ala?Val

340 345 350

Leu?Thr?Phe?Thr?Asp?Asp?Ala?Leu?Glu?Glu?Ile?Ala?Asn?Gln?Ala?Leu

355 360 365

Glu?Arg?Lys?Thr?Gly?Ala?Arg?Gly?Leu?Arg?Ala?Ile?Met?Glu?Glu?Ile

370 375 380

Leu?Val?Pro?Ile?Met?Tyr?Asp?Leu?Pro?Asp?Arg?Lys?Asp?Val?Gly?Glu

385 390 395 400

Val?Ile?Ile?Asn?Gly?Ala?Val?Ala?Arg?Gly?Glu?Ala?Glu?Pro?Glu?Met

405 410 415

Leu?Glu?Ala?Val?Ala?Glu?Glu?Lys?Thr?Ala

420 425

<210>71

<211>1401

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1378)

<223>FRXA01120

<400>71

acaggtaaag?cgctaagatg?gaacaaccca?ttgccaatat?tgttggttag?agttgtacgc?60

agtaaatctt?ttcaatcgtg?gaagcgggtc?tcacagtcta?atg?gca?cgt?atg?cag 115

Met?Ala?Arg?Met?Gln

1 5

gaa?agc?gcc?gat?ctg?ctc?aaa?tgt?tcc?ttc?tgc?gga?aag?agc?caa?aag 163

Glu?Ser?Ala?Asp?Leu?Leu?Lys?Cys?Ser?Phe?Cys?Gly?Lys?Ser?Gln?Lys

10 15 20

cag?gta?aaa?aaa?ctc?atc?gcg?ggt?ggc?gcc?gta?tat?atc?tgt?gat?gag 211

Gln?Val?Lys?Lys?Leu?Ile?Ala?Gly?Gly?Ala?Val?Tyr?Ile?Cys?Asp?Glu

25 30 35

tgc?att?gag?ctg?tgc?aac?gag?att?att?gaa?gaa?gaa?ctc?ggt?caa?gct 259

Cys?Ile?Glu?Leu?Cys?Asn?Glu?Ile?Ile?Glu?Glu?Glu?Leu?Gly?Gln?Ala

40 45 50

caa?cac?gac?gag?cag?gag?cgc?aac?gag?ctc?ccc?aag?ccg?tcg?gag?att 307

Gln?His?Asp?Glu?Gln?Glu?Arg?Asn?Glu?Leu?Pro?Lys?Pro?Ser?Glu?Ile

55 60 65

tca?gcc?ttc?ctt?gat?act?tat?gtc?atc?ggg?cag?gac?cca?gca?aaa?cgt 355

Ser?Ala?Phe?Leu?Asp?Thr?Tyr?Val?Ile?Gly?Gln?Asp?Pro?Ala?Lys?Arg

70 75 80 85

atc?ctg?tcg?gtt?gcg?gtg?tac?aac?cat?tac?aag?cgt?ctc?cgc?gca?tcg 403

Ile?Leu?Ser?Val?Ala?Val?Tyr?Asn?His?Tyr?Lys?Arg?Leu?Arg?Ala?Ser

90 95 100

gaa?acc?atc?ggt?cgt?cgc?agg?aat?gac?gag?cct?gaa?acc?gaa?ctg?gtt 451

Glu?Thr?Ile?Gly?Arg?Arg?Arg?Asn?Asp?Glu?Pro?Glu?Thr?Glu?Leu?Val

105 110 115

aag?tcc?aat?att?ttg?atg?ctc?ggc?ccc?act?ggc?tcc?ggc?aag?act?ttc 499

Lys?Ser?Asn?Ile?Leu?Met?Leu?Gly?Pro?Thr?Gly?Ser?Gly?Lys?Thr?Phe

120 125 130

ctt?gcc?cag?act?ttg?gca?aag?ctg?ctg?gat?gtt?cct?ttt?gct?atc?gcg 547

Leu?Ala?Gln?Thr?Leu?Ala?Lys?Leu?Leu?Asp?Val?Pro?Phe?Ala?Ile?Ala

135 140 145

gat?gcc?acc?tca?ctg?acc?gag?gct?ggt?tat?gtg?ggc?gag?gat?gtg?gaa 595

Asp?Ala?Thr?Ser?Leu?Thr?Glu?Ala?Gly?Tyr?Val?Gly?Glu?Asp?Val?Glu

150 155 160 165

aac?atc?ttg?ctc?aag?ctg?ctt?cag?gct?gct?gat?ttt?gat?gtg?gaa?cgt 643

Asn?Ile?Leu?Leu?Lys?Leu?Leu?Gln?Ala?Ala?Asp?Phe?Asp?Val?Glu?Arg

170 175 180

gca?cag?cgc?ggc?atc?att?tac?atc?gat?gaa?gtg?gac?aag?att?tcc?cgc 691

Ala?Gln?Arg?Gly?Ile?Ile?Tyr?Ile?Asp?Glu?Val?Asp?Lys?Ile?Ser?Arg

185 190 195

aag?tct?gaa?aac?cca?tcg?atc?act?cgc?gat?gtt?tcc?ggt?gaa?ggc?gtg 739

Lys?Ser?Glu?Asn?Pro?Ser?Ile?Thr?Arg?Asp?Val?Ser?Gly?Glu?Gly?Val

200 205 210

cag?cag?gca?ctg?ctg?aaa?att?ttg?gaa?ggc?act?gtc?gcc?gca?atc?cca 787

Gln?Gln?Ala?Leu?Leu?Lys?Ile?Leu?Glu?Gly?Thr?Val?Ala?Ala?Ile?Pro

215 220 225

ccg?cag?gga?gga?cgc?aag?cac?ccc?aac?cag?gat?ttc?atc?cag?ctg?gat 835

Pro?Gln?Gly?Gly?Arg?Lys?His?Pro?Asn?Gln?Asp?Phe?Ile?Gln?Leu?Asp

230 235 240 245

acc?acc?aac?att?ttg?ttc?atc?gtt?gct?ggt?gcg?ttc?tct?ggt?ctg?gag 883

Thr?Thr?Asn?Ile?Leu?Phe?Ile?Val?Ala?Gly?Ala?Phe?Ser?Gly?Leu?Glu

250 255 260

aag?gtc?atc?gcg?gac?cgc?aat?ggc?aag?aaa?ggc?ttg?ggc?ttc?ggt?gtg 931

Lys?Val?Ile?Ala?Asp?Arg?Asn?Gly?Lys?Lys?Gly?Leu?Gly?Phe?Gly?Val

265 270 275

gag?gtc?tct?tcc?aag?aag?gaa?gaa?gcc?aac?att?gtg?gat?atc?ttc?aag 979

Glu?Val?Ser?Ser?Lys?Lys?Glu?Glu?Ala?Asn?Ile?Val?Asp?Ile?Phe?Lys

280 285 290

gat?gtc?ctc?cct?gag?gac?ctg?gtg?aag?ttt?ggt?ctc?atc?cca?gaa?ttc 1027

Asp?Val?Leu?Pro?Glu?Asp?Leu?Val?Lys?Phe?Gly?Leu?Ile?Pro?Glu?Phe

295 300 305

att?ggg?cgt?ctg?cca?gtc?gtt?gcc?acc?gta?tcc?aac?ctg?gat?cag?aaa 1075

Ile?Gly?Arg?Leu?Pro?Val?Val?Ala?Thr?Val?Ser?Asn?Leu?Asp?Gln?Lys

310 315 320 325

tct?ctg?gtc?aag?gtt?ctc?acg?gag?cct?cgt?aac?tca?ttg?gtg?aag?cag 1123

Ser?Leu?Val?Lys?Val?Leu?Thr?Glu?Pro?Arg?Asn?Ser?Leu?Val?Lys?Gln

330 335 340

tat?cga?cgt?ctg?ttt?gaa?atg?gat?gac?gct?gtg?ttg?acc?ttt?act?gat 1171

Tyr?Arg?Arg?Leu?Phe?Glu?Met?Asp?Asp?Ala?Val?Leu?Thr?Phe?Thr?Asp

345 350 355

gat?gct?ttg?gag?gag?atc?gct?aat?cag?gca?ctc?gag?cgc?aaa?act?ggc 1219

Asp?Ala?Leu?Glu?Glu?Ile?Ala?Asn?Gln?Ala?Leu?Glu?Arg?Lys?Thr?Gly

360 365 370

gcc?cgt?ggc?ctg?cgc?gcg?atc?atg?gaa?gag?atc?ctg?gtt?ccg?atc?atg 1267

Ala?Arg?Gly?Leu?Arg?Ala?Ile?Met?Glu?Glu?Ile?Leu?Val?Pro?Ile?Met

375 380 385

tat?gac?ctc?cca?gac?cgt?aaa?gac?gtt?ggc?gaa?gtc?atc?atc?aac?ggt 1315

Tyr?Asp?Leu?Pro?Asp?Arg?Lys?Asp?Val?Gly?Glu?Val?Ile?Ile?Asn?Gly

390 395 400 405

gcc?gtt?gcc?cgt?ggc?gaa?gcc?gaa?cca?gag?atg?ttg?gaa?gct?gtc?gca 1363

Ala?Val?Ala?Arg?Gly?Glu?Ala?Glu?Pro?Glu?Met?Leu?Glu?Ala?Val?Ala

410 415 420

gaa?gaa?aag?acc?gcg?tagttggcag?gagttatcac?cgg 1401

Glu?Glu?Lys?Thr?Ala

425

<210>72

<211>426

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>72

Met?Ala?Arg?Met?Gln?Glu?Ser?Ala?Asp?Leu?Leu?Lys?Cys?Ser?Phe?Cys

1 5 10 15

Gly?Lys?Ser?Gln?Lys?Gln?Val?Lys?Lys?Leu?Ile?Ala?Gly?Gly?Ala?Val

20 25 30

Tyr?Ile?Cys?Asp?Glu?Cys?Ile?Glu?Leu?Cys?Asn?Glu?Ile?Ile?Glu?Glu

35 40 45

Glu?Leu?Gly?Gln?Ala?Gln?His?Asp?Glu?Gln?Glu?Arg?Asn?Glu?Leu?Pro

50 55 60

Lys?Pro?Ser?Glu?Ile?Ser?Ala?Phe?Leu?Asp?Thr?Tyr?Val?Ile?Gly?Gln

65 70 75 80

Asp?Pro?Ala?Lys?Arg?Ile?Leu?Ser?Val?Ala?Val?Tyr?Asn?His?Tyr?Lys

85 90 95

Arg?Leu?Arg?Ala?Ser?Glu?Thr?Ile?Gly?Arg?Arg?Arg?Asn?Asp?Glu?Pro

100 105 110

Glu?Thr?Glu?Leu?Val?Lys?Ser?Asn?Ile?Leu?Met?Leu?Gly?Pro?Thr?Gly

115 120 125

Ser?Gly?Lys?Thr?Phe?Leu?Ala?Gln?Thr?Leu?Ala?Lys?Leu?Leu?Asp?Val

130 135 140

Pro?Phe?Ala?Ile?Ala?Asp?Ala?Thr?Ser?Leu?Thr?Glu?Ala?Gly?Tyr?Val

145 150 155 160

Gly?Glu?Asp?Val?Glu?Asn?Ile?Leu?Leu?Lys?Leu?Leu?Gln?Ala?Ala?Asp

165 170 175

Phe?Asp?Val?Glu?Arg?Ala?Gln?Arg?Gly?Ile?Ile?Tyr?Ile?Asp?Glu?Val

180 185 190

Asp?Lys?Ile?Ser?Arg?Lys?Ser?Glu?Asn?Pro?Ser?Ile?Thr?Arg?Asp?Val

195 200 205

Ser?Gly?Glu?Gly?Val?Gln?Gln?Ala?Leu?Leu?Lys?Ile?Leu?Glu?Gly?Thr

210 215 220

Val?Ala?Ala?Ile?Pro?Pro?Gln?Gly?Gly?Arg?Lys?His?Pro?Asn?Gln?Asp

225 230 235 240

Phe?Ile?Gln?Leu?Asp?Thr?Thr?Asn?Ile?Leu?Phe?Ile?Val?Ala?Gly?Ala

245 250 255

Phe?Ser?Gly?Leu?Glu?Lys?Val?Ile?Ala?Asp?Arg?Asn?Gly?Lys?Lys?Gly

260 265 270

Leu?Gly?Phe?Gly?Val?Glu?Val?Ser?Ser?Lys?Lys?Glu?Glu?Ala?Asn?Ile

275 280 285

Val?Asp?Ile?Phe?Lys?Asp?Val?Leu?Pro?Glu?Asp?Leu?Val?Lys?Phe?Gly

290 295 300

Leu?Ile?Pro?Glu?Phe?Ile?Gly?Arg?Leu?Pro?Val?Val?Ala?Thr?Val?Ser

305 310 315 320

Asn?Leu?Asp?Gln?Lys?Ser?Leu?Val?Lys?Val?Leu?Thr?Glu?Pro?Arg?Asn

325 330 335

Ser?Leu?Val?Lys?Gln?Tyr?Arg?Arg?Leu?Phe?Glu?Met?Asp?Asp?Ala?Val

340 345 350

Leu?Thr?Phe?Thr?Asp?Asp?Ala?Leu?Glu?Glu?Ile?Ala?Asn?Gln?Ala?Leu

355 360 365

Glu?Arg?Lys?Thr?Gly?Ala?Arg?Gly?Leu?Arg?Ala?Ile?Met?Glu?Glu?Ile

370 375 380

Leu?Val?Pro?Ile?Met?Tyr?Asp?Leu?Pro?Asp?Arg?Lys?Asp?Val?Gly?Glu

385 390 395 400

Val?Ile?Ile?Asn?Gly?Ala?Val?Ala?Arg?Gly?Glu?Ala?Glu?Pro?Glu?Met

405 410 415

Leu?Glu?Ala?Val?Ala?Glu?Glu?Lys?Thr?Ala

420 425

<210>73

<211>1065

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1042)

<223>RXA00744

<400>73

tctgagtcgg?tagaagtatt?acccagtgac?ttaagtttct?tagatttttt?tgagcaacag?60

cgaccagcca?cgttagtgtg?gtcgagtaga?ggatagctac?atg?ggg?aac?tgg?gca 115

Met?Gly?Asn?Trp?Ala

1 5

gag?att?act?gat?gaa?att?tct?aag?att?tac?caa?gat?aat?cag?tac?aag 163

Glu?Ile?Thr?Asp?Glu?Ile?Ser?Lys?Ile?Tyr?Gln?Asp?Asn?Gln?Tyr?Lys

10 15 20

att?aga?caa?ata?aat?gat?gtt?gac?gca?gta?agc?gat?aaa?cgt?aga?gaa 211

Ile?Arg?Gln?Ile?Asn?Asp?Val?Asp?Ala?Val?Ser?Asp?Lys?Arg?Arg?Glu

25 30 35

gcg?cta?caa?gca?ctg?ttt?gaa?cat?act?ggt?cga?aat?gta?atc?gtc?tat 259

Ala?Leu?Gln?Ala?Leu?Phe?Glu?His?Thr?Gly?Arg?Asn?Val?Ile?Val?Tyr

40 45 50

tat?tca?gcg?tgg?tta?gaa?aat?ggt?cga?cga?ttt?tcc?ggg?caa?tct?acg 307

Tyr?Ser?Ala?Trp?Leu?Glu?Asn?Gly?Arg?Arg?Phe?Ser?Gly?Gln?Ser?Thr

55 60 65

gat?ttt?tcg?gta?aat?gat?act?gat?aaa?aac?agt?ttt?atg?act?gcg?ctc 355

Asp?Phe?Ser?Val?Asn?Asp?Thr?Asp?Lys?Asn?Ser?Phe?Met?Thr?Ala?Leu

70 75 80 85

cat?aag?ttg?gat?cag?agt?aaa?ggt?ctc?gat?ctt?atc?ctc?cac?act?ccg 403

His?Lys?Leu?Asp?Gln?Ser?Lys?Gly?Leu?Asp?Leu?Ile?Leu?His?Thr?Pro

90 95 100

ggt?gga?gat?gtt?gct?gcg?aca?gag?tcg?tta?gta?gat?tac?att?cac?gca 451

Gly?Gly?Asp?Val?Ala?Ala?Thr?Glu?Ser?Leu?Val?Asp?Tyr?Ile?His?Ala

105 110 115

ctc?ttt?ggt?caa?gat?ttc?aga?gtc?att?gtc?ccc?caa?ctc?gca?atg?tca 499

Leu?Phe?Gly?Gln?Asp?Phe?Arg?Val?Ile?Val?Pro?Gln?Leu?Ala?Met?Ser

120 125 130

gca?gga?aca?atg?atc?gca?ctt?tcg?tcc?aaa?gag?att?gtt?atg?ggg?aag 547

Ala?Gly?Thr?Met?Ile?Ala?Leu?Ser?Ser?Lys?Glu?Ile?Val?Met?Gly?Lys

135 140 145

cat?tct?agt?ctt?ggc?ccc?att?gat?cct?cag?ttt?aac?ggc?cta?ccg?gca 595

His?Ser?Ser?Leu?Gly?Pro?Ile?Asp?Pro?Gln?Phe?Asn?Gly?Leu?Pro?Ala

150 155 160 165

cac?ggg?tta?ttg?gaa?gaa?ttt?gag?caa?gcg?aag?aaa?gag?gtc?tct?gag 643

His?Gly?Leu?Leu?Glu?Glu?Phe?Glu?Gln?Ala?Lys?Lys?Glu?Val?Ser?Glu

170 175 180

aat?ccg?cag?act?gct?cat?ata?tgg?cag?gtg?atc?ttg?aat?aaa?tac?aac 691

Asn?Pro?Gln?Thr?Ala?His?Ile?Trp?Gln?Val?Ile?Leu?Asn?Lys?Tyr?Asn

185 190 195

ccc?acg?atg?ttg?ggt?gaa?gct?aaa?aaa?gct?att?cag?tgg?tcc?aac?tcg 739

Pro?Thr?Met?Leu?Gly?Glu?Ala?Lys?Lys?Ala?Ile?Gln?Trp?Ser?Asn?Ser

200 205 210

atg?gtt?aag?cag?tgg?ctt?gaa?aag?ggt?atg?ttt?tta?gac?gag?cct?gac 787

Met?Val?Lys?Gln?Trp?Leu?Glu?Lys?Gly?Met?Phe?Leu?Asp?Glu?Pro?Asp

215 220 225

aaa?gaa?gaa?aaa?gcc?act?cgc?gct?atc?aaa?gag?ctc?gct?gat?cat?tcc 835

Lys?Glu?Glu?Lys?Ala?Thr?Arg?Ala?Ile?Lys?Glu?Leu?Ala?Asp?His?Ser

230 235 240 245

gtt?act?ctt?gcg?cat?aat?cga?cac?att?tcg?gtc?agt?aaa?gca?ctt?gag 883

Val?Thr?Leu?Ala?His?Asn?Arg?His?Ile?Ser?Val?Ser?Lys?Ala?Leu?Glu

250 255 260

ctg?gga?ttg?aat?atc?aaa?gaa?ctt?gag?agc?gat?cca?aag?ctt?caa?gat 931

Leu?Gly?Leu?Asn?Ile?Lys?Glu?Leu?Glu?Ser?Asp?Pro?Lys?Leu?Gln?Asp

265 270 275

tta?gtt?ctt?act?ctt?cac?cac?ctg?tcc?gtt?att?gct?gcg?caa?cga?gga 979

Leu?Val?Leu?Thr?Leu?His?His?Leu?Ser?Val?Ile?Ala?Ala?Gln?Arg?Gly

280 285 290

cca?tta?att?aag?ttt?gtc?gtc?aat?cat?gac?aac?cgt?ggc?act?ttt?ctg 1027

Pro?Leu?Ile?Lys?Phe?Val?Val?Asn?His?Asp?Asn?Arg?Gly?Thr?Phe?Leu

295 300 305

cag?ggg?cat?gaa?aac?taattaagtg?atgcaatagt?cta 1065

Gln?Gly?His?Glu?Asn

310

<210>74

<211>314

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>74

Met?Gly?Asn?Trp?Ala?Glu?Ile?Thr?Asp?Glu?Ile?Ser?Lys?Ile?Tyr?Gln

1 5 10 15

Asp?Asn?Gln?Tyr?Lys?Ile?Arg?Gln?Ile?Asn?Asp?Val?Asp?Ala?Val?Ser

20 25 30

Asp?Lys?Arg?Arg?Glu?Ala?Leu?Gln?Ala?Leu?Phe?Glu?His?Thr?Gly?Arg

35 40 45

Asn?Val?Ile?Val?Tyr?Tyr?Ser?Ala?Trp?Leu?Glu?Asn?Gly?Arg?Arg?Phe

50 55 60

Ser?Gly?Gln?Ser?Thr?Asp?Phe?Ser?Val?Asn?Asp?Thr?Asp?Lys?Asn?Ser

65 70 75 80

Phe?Met?Thr?Ala?Leu?His?Lys?Leu?Asp?Gln?Ser?Lys?Gly?Leu?Asp?Leu

85 90 95

Ile?Leu?His?Thr?Pro?Gly?Gly?Asp?Val?Ala?Ala?Thr?Glu?Ser?Leu?Val

100 105 110

Asp?Tyr?Ile?His?Ala?Leu?Phe?Gly?Gln?Asp?Phe?Arg?Val?Ile?Val?Pro

115 120 125

Gln?Leu?Ala?Met?Ser?Ala?Gly?Thr?Met?Ile?Ala?Leu?Ser?Ser?Lys?Glu

130 135 140

Ile?Val?Met?Gly?Lys?His?Ser?Ser?Leu?Gly?Pro?Ile?Asp?Pro?Gln?Phe

145 150 155 160

Asn?Gly?Leu?Pro?Ala?His?Gly?Leu?Leu?Glu?Glu?Phe?Glu?Gln?Ala?Lys

165 170 175

Lys?Glu?Val?Ser?Glu?Asn?Pro?Gln?Thr?Ala?His?Ile?Trp?Gln?Val?Ile

180 185 190

Leu?Asn?Lys?Tyr?Asn?Pro?Thr?Met?Leu?Gly?Glu?Ala?Lys?Lys?Ala?Ile

195 200 205

Gln?Trp?Ser?Asn?Ser?Met?Val?Lys?Gln?Trp?Leu?Glu?Lys?Gly?Met?Phe

210 215 220

Leu?Asp?Glu?Pro?Asp?Lys?Glu?Glu?Lys?Ala?Thr?Arg?Ala?Ile?Lys?Glu

225 230 235 240

Leu?Ala?Asp?His?Ser?Val?Thr?Leu?Ala?His?Asn?Arg?His?Ile?Ser?Val

245 250 255

Ser?Lys?Ala?Leu?Glu?Leu?Gly?Leu?Asn?Ile?Lys?Glu?Leu?Glu?Ser?Asp

260 265 270

Pro?Lys?Leu?Gln?Asp?Leu?Val?Leu?Thr?Leu?His?His?Leu?Ser?Val?Ile

275 280 285

Ala?Ala?Gln?Arg?Gly?Pro?Leu?Ile?Lys?Phe?Val?Val?Asn?His?Asp?Asn

290 295 300

Arg?Gly?Thr?Phe?Leu?Gln?Gly?His?Glu?Asn

305 310

<210>75

<211>957

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(934)

<223>RXA00844

<400>75

ggtgacggcc?aaaggcgcgc?gcattgcgcg?ccccaaaatc?gacgtcattg?acagcatctt?60

gtgacaacat?tttgtagagc?aaccatctag?actgttcttt?atg?tct?tct?gcg?tca 115

Met?Ser?Ser?Ala?Ser

1 5

ttt?acc?acc?aaa?gca?ctg?tcc?gta?ctc?gca?gct?tta?acg?gct?gcg?tct 163

Phe?Thr?Thr?Lys?Ala?Leu?Ser?Val?Leu?Ala?Ala?Leu?Thr?Ala?Ala?Ser

10 15 20

gcc?ccc?tta?gtg?gcg?gcg?tca?cct?gca?cat?gct?ttg?gca?aat?gct?cgc 211

Ala?Pro?Leu?Val?Ala?Ala?Ser?Pro?Ala?His?Ala?Leu?Ala?Asn?Ala?Arg

25 30 35

aac?gtt?acg?ggt?tca?agc?acc?act?tca?gat?tca?att?gtt?cgt?ctg?cac 259

Asn?Val?Thr?Gly?Ser?Ser?Thr?Thr?Ser?Asp?Ser?Ile?Val?Arg?Leu?His

40 45 50

atc?ggt?aac?act?gca?tgt?aca?gga?acc?atg?atc?acc?cca?acg?tgg?gcg 307

Ile?Gly?Asn?Thr?Ala?Cys?Thr?Gly?Thr?Met?Ile?Thr?Pro?Thr?Trp?Ala

55 60 65

atc?acc?gcc?cgc?cac?tgt?atc?cct?gag?ggc?ggt?att?gcc?ggt?gca?gct 355

Ile?Thr?Ala?Arg?His?Cys?Ile?Pro?Glu?Gly?Gly?Ile?Ala?Gly?Ala?Ala

70 75 80 85

att?ggt?tca?agc?act?ttg?agc?caa?ttt?cag?cag?gtg?tcc?caa?gcg?atc 403

Ile?Gly?Ser?Ser?Thr?Leu?Ser?Gln?Phe?Gln?Gln?Val?Ser?Gln?Ala?Ile

90 95 100

ttg?cac?cct?act?gcg?gac?tta?gct?ctc?gtt?gag?ctt?ccc?aat?cag?gca 451

Leu?His?Pro?Thr?Ala?Asp?Leu?Ala?Leu?Val?Glu?Leu?Pro?Asn?Gln?Ala

105 110 115

agt?tcc?aac?acg?gtt?gat?ctc?tac?ggt?gca?cac?gtg?cag?cct?ggt?gaa 499

Ser?Ser?Asn?Thr?Val?Asp?Leu?Tyr?Gly?Ala?His?Val?Gln?Pro?Gly?Glu

120 125 130

aat?ggt?caa?gca?gcc?ggc?tgg?ggt?ggg?tac?tct?gcc?ttt?ggc?caa?aat 547

Asn?Gly?Gln?Ala?Ala?Gly?Trp?Gly?Gly?Tyr?Ser?Ala?Phe?Gly?Gln?Asn

135 140 145

gtt?gca?cag?caa?gcc?gat?gtg?caa?att?caa?cgc?agg?gta?gtc?aat?gtg 595

Val?Ala?Gln?Gln?Ala?Asp?Val?Gln?Ile?Gln?Arg?Arg?Val?Val?Asn?Val

150 155 160 165

cca?agc?ccc?gac?cgc?acc?gct?gtg?ctg?ctt?gaa?ggc?act?gtt?tct?aac 643

Pro?Ser?Pro?Asp?Arg?Thr?Ala?Val?Leu?Leu?Glu?Gly?Thr?Val?Ser?Asn

170 175 180

ggt?cgt?ctc?gta?cca?ggc?gat?tcc?ggc?gga?cct?ttg?tac?atc?aat?ggt 691

Gly?Arg?Leu?Val?Pro?Gly?Asp?Ser?Gly?Gly?Pro?Leu?Tyr?Ile?Asn?Gly

185 190 195

caa?ctg?gct?ggt?gtg?ctc?agc?atg?tcc?act?gac?gta?gaa?aac?gat?gca 739

Gln?Leu?Ala?Gly?Val?Leu?Ser?Met?Ser?Thr?Asp?Val?Glu?Asn?Asp?Ala

200 205 210

cta?gac?ggc?acc?gtc?ggc?tgg?tac?atc?ccc?gtt?gct?gaa?cac?gcc?gag 787

Leu?Asp?Gly?Thr?Val?Gly?Trp?Tyr?Ile?Pro?Val?Ala?Glu?His?Ala?Glu

215 220 225

tgg?atc?gcc?tac?tac?acc?ggc?aag?cac?att?gcc?ccc?att?gct?ggt?gcg 835

Trp?Ile?Ala?Tyr?Tyr?Thr?Gly?Lys?His?Ile?Ala?Pro?Ile?Ala?Gly?Ala

230 235 240 245

ccc?gca?gaa?ctt?gtt?gac?gcc?acc?gcc?aac?ccc?acc?ttc?atc?cct?gct 883

Pro?Ala?Glu?Leu?Val?Asp?Ala?Thr?Ala?Asn?Pro?Thr?Phe?Ile?Pro?Ala

250 255 260

cca?cag?cct?ttc?acc?ggt?tca?tcc?atc?ggt?ggt?tgg?gcg?ctg?ggc?agc 931

Pro?Gln?Pro?Phe?Thr?Gly?Ser?Ser?Ile?Gly?Gly?Trp?Ala?Leu?Gly?Ser

265 270 275

tcc?tagaatatgc?tgatctccct?gct 957

Ser

<210>76

<211>278

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>76

Met?Ser?Ser?Ala?Ser?Phe?Thr?Thr?Lys?Ala?Leu?Ser?Val?Leu?Ala?Ala

1 5 10 15

Leu?Thr?Ala?Ala?Ser?Ala?Pro?Leu?Val?Ala?Ala?Ser?Pro?Ala?His?Ala

20 25 30

Leu?Ala?Asn?Ala?Arg?Asn?Val?Thr?Gly?Ser?Ser?Thr?Thr?Ser?Asp?Ser

35 40 45

Ile?Val?Arg?Leu?His?Ile?Gly?Asn?Thr?Ala?Cys?Thr?Gly?Thr?Met?Ile

50 55 60

Thr?Pro?Thr?Trp?Ala?Ile?Thr?Ala?Arg?His?Cys?Ile?Pro?Glu?Gly?Gly

65 70 75 80

Ile?Ala?Gly?Ala?Ala?Ile?Gly?Ser?Ser?Thr?Leu?Ser?Gln?Phe?Gln?Gln

85 90 95

Val?Ser?Gln?Ala?Ile?Leu?His?Pro?Thr?Ala?Asp?Leu?Ala?Leu?Val?Glu

100 105 110

Leu?Pro?Asn?Gln?Ala?Ser?Ser?Asn?Thr?Val?Asp?Leu?Tyr?Gly?Ala?His

115 120 125

Val?Gln?Pro?Gly?Glu?Asn?Gly?Gln?Ala?Ala?Gly?Trp?Gly?Gly?Tyr?Ser

130 135 140

Ala?Phe?Gly?Gln?Asn?Val?Ala?Gln?Gln?Ala?Asp?Val?Gln?Ile?Gln?Arg

145 150 155 160

Arg?Val?Val?Asn?Val?Pro?Ser?Pro?Asp?Arg?Thr?Ala?Val?Leu?Leu?Glu

165 170 175

Gly?Thr?Val?Ser?Asn?Gly?Arg?Leu?Val?Pro?Gly?Asp?Ser?Gly?Gly?Pro

180 185 190

Leu?Tyr?Ile?Asn?Gly?Gln?Leu?Ala?Gly?Val?Leu?Ser?Met?Ser?Thr?Asp

195 200 205

Val?Glu?Asn?Asp?Ala?Leu?Asp?Gly?Thr?Val?Gly?Trp?Tyr?Ile?Pro?Val

210 215 220

Ala?Glu?His?Ala?Glu?Trp?Ile?Ala?Tyr?Tyr?Thr?Gly?Lys?His?Ile?Ala

225 230 235 240

Pro?Ile?Ala?Gly?Ala?Pro?Ala?Glu?Leu?Val?Asp?Ala?Thr?Ala?Asn?Pro

245 250 255

Thr?Phe?Ile?Pro?Ala?Pro?Gln?Pro?Phe?Thr?Gly?Ser?Ser?Ile?Gly?Gly

260 265 270

Trp?Ala?Leu?Gly?Ser?Ser

275

<210>77

<211>958

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(958)

<223>RXA01151

<400>77

ccaggcgttt?ggctgatggc?gtggagcctc?ctcgtccgca?gcgtaaggca?cgtcgataaa?60

aagacctagt?tggagggcgt?aaagggttag?agtggtgacc?atg?agt?tca?cca?act 115

Met?Ser?Ser?Pro?Thr

1 5

gat?tct?tcg?ccc?tct?aat?tct?ttt?agc?gac?ttc?aac?cgg?gag?gaa?cag 163

Asp?Ser?Ser?Pro?Ser?Asn?Ser?Phe?Ser?Asp?Phe?Asn?Arg?Glu?Glu?Gln

10 15 20

tcc?cgg?tta?tct?gat?gag?gtg?cgc?cag?ctc?aag?cgc?acc?aac?tct?gat 211

Ser?Arg?Leu?Ser?Asp?Glu?Val?Arg?Gln?Leu?Lys?Arg?Thr?Asn?Ser?Asp

25 30 35

ctt?ggg?gca?cgt?aat?gcc?aag?ctc?gcg?gag?atg?ctg?aag?tcg?tct?cgg 259

Leu?Gly?Ala?Arg?Asn?Ala?Lys?Leu?Ala?Glu?Met?Leu?Lys?Ser?Ser?Arg

40 45 50

gat?aaa?ttg?tct?gtg?ctg?ttt?tct?cag?ttg?gag?gat?atg?gct?cag?ccg 307

Asp?Lys?Leu?Ser?Val?Leu?Phe?Ser?Gln?Leu?Glu?Asp?Met?Ala?Gln?Pro

55 60 65

cca?tcg?gtg?tat?ggc?act?ttc?ttg?gaa?acc?gcg?aaa?gac?ggt?tct?aat 355

Pro?Ser?Val?Tyr?Gly?Thr?Phe?Leu?Glu?Thr?Ala?Lys?Asp?Gly?Ser?Asn

70 75 80 85

gcg?gag?atc?ttt?gct?ggt?gga?cgt?cgc?atg?cgt?gtg?gct?gtt?tct?cct 403

Ala?Glu?Ile?Phe?Ala?Gly?Gly?Arg?Arg?Met?Arg?Val?Ala?Val?Ser?Pro

90 95 100

atg?ctg?tgt?gcc?gcg?gat?ttg?atg?ccg?ggt?gtg?cag?gtt?cgt?ttg?ggt 451

Met?Leu?Cys?Ala?Ala?Asp?Leu?Met?Pro?Gly?Val?Gln?Val?Arg?Leu?Gly

105 110 115

gaa?ggc?aat?caa?gtt?ctt?gag?gcc?tgt?gat?ttt?gaa?caa?acc?ggt?gaa 499

Glu?Gly?Asn?Gln?Val?Leu?Glu?Ala?Cys?Asp?Phe?Glu?Gln?Thr?Gly?Glu

120 125 130

tta?gcc?acg?ttg?atg?gaa?atg?att?ggc?cgg?gat?cgt?gct?ttg?gtt?tca 547

Leu?Ala?Thr?Leu?Met?Glu?Met?Ile?Gly?Arg?Asp?Arg?Ala?Leu?Val?Ser

135 140 145

gat?cgc?tcg?ggg?gag?gag?cgc?gtc?gtc?aag?ctt?gct?ggt?ccg?ttg?atg 595

Asp?Arg?Ser?Gly?Glu?Glu?Arg?Val?Val?Lys?Leu?Ala?Gly?Pro?Leu?Met

150 155 160 165

gat?cgc?acc?gca?aag?ctg?ccg?cgc?ccc?ggt?gac?acc?ctg?ctt?gtt?gac 643

Asp?Arg?Thr?Ala?Lys?Leu?Pro?Arg?Pro?Gly?Asp?Thr?Leu?Leu?Val?Asp

170 175 180

cgc?aaa?gcg?ggc?tac?gct?ttt?gag?gcg?att?gcc?aag?acg?gaa?att?tcg 691

Arg?Lys?Ala?Gly?Tyr?Ala?Phe?Glu?Ala?Ile?Ala?Lys?Thr?Glu?Ile?Ser

185 190 195

agg?ctt?gcg?ctg?gaa?gag?gcg?cca?gat?gtg?tct?tat?cag?gat?att?ggt 739

Arg?Leu?Ala?Leu?Glu?Glu?Ala?Pro?Asp?Val?Ser?Tyr?Gln?Asp?Ile?Gly

200 205 210

ggc?ttg?gat?gat?cag?att?gaa?ttg?att?caa?gat?gcc?gtt?gag?ctg?cca 787

Gly?Leu?Asp?Asp?Gln?Ile?Glu?Leu?Ile?Gln?Asp?Ala?Val?Glu?Leu?Pro

215 220 225

ttt?ttg?cac?ccg?gag?atg?tac?cgc?gcc?tac?aac?ctg?cat?cca?cca?aag 835

Phe?Leu?His?Pro?Glu?Met?Tyr?Arg?Ala?Tyr?Asn?Leu?His?Pro?Pro?Lys

230 235 240 245

ggc?gtg?ctg?ctg?tac?ggc?cct?ccc?ggc?tgt?gga?aag?acg?ctg?att?gct 883

Gly?Val?Leu?Leu?Tyr?Gly?Pro?Pro?Gly?Cys?Gly?Lys?Thr?Leu?Ile?Ala

250 255 260

aag?gct?gtg?gct?aat?tct?ttg?gcc?aac?cgc?atc?ggt?gag?act?ggc?acc 931

Lys?Ala?Val?Ala?Asn?Ser?Leu?Ala?Asn?Arg?Ile?Gly?Glu?Thr?Gly?Thr

265 270 275

tcg?tac?ttc?atc?aac?gtc?aag?ggg?cca 958

Ser?Tyr?Phe?Ile?Asn?Val?Lys?Gly?Pro

280 285

<210>78

<211>286

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>78

Met?Ser?Ser?Pro?Thr?Asp?Ser?Ser?Pro?Ser?Asn?Ser?Phe?Ser?Asp?Phe

1 5 10 15

Asn?Arg?Glu?Glu?Gln?Ser?Arg?Leu?Ser?Asp?Glu?Val?Arg?Gln?Leu?Lys

20 25 30

Arg?Thr?Asn?Ser?Asp?Leu?Gly?Ala?Arg?Asn?Ala?Lys?Leu?Ala?Glu?Met

35 40 45

Leu?Lys?Ser?Ser?Arg?Asp?Lys?Leu?Ser?Val?Leu?Phe?Ser?Gln?Leu?Glu

50 55 60

Asp?Met?Ala?Gln?Pro?Pro?Ser?Val?Tyr?Gly?Thr?phe?Leu?Glu?Thr?Ala

65 70 75 80

Lys?Asp?Gly?Ser?Asn?Ala?Glu?Ile?Phe?Ala?Gly?Gly?Arg?Arg?Met?Arg

85 90 95

Val?Ala?Val?Ser?Pro?Met?Leu?Cys?Ala?Ala?Asp?Leu?Met?Pro?Gly?Val

100 105 110

Gln?Val?Arg?Leu?Gly?Glu?Gly?Asn?Gln?Val?Leu?Glu?Ala?Cys?Asp?Phe

115 120 125

Glu?Gln?Thr?Gly?Glu?Leu?Ala?Thr?Leu?Met?Glu?Met?Ile?Gly?Arg?Asp

130 135 140

Arg?Ala?Leu?Val?Ser?Asp?Arg?Ser?Gly?Glu?Glu?Arg?Val?Val?Lys?Leu

145 150 155 160

Ala?Gly?Pro?Leu?Met?Asp?Arg?Thr?Ala?Lys?Leu?Pro?Arg?Pro?Gly?Asp

165 170 175

Thr?Leu?Leu?Val?Asp?Arg?Lys?Ala?Gly?Tyr?Ala?Phe?Glu?Ala?Ile?Ala

180 185 190

Lys?Thr?Glu?Ile?Ser?Arg?Leu?Ala?Leu?Glu?Glu?Ala?Pro?Asp?Val?Ser

195 200 205

Tyr?Gln?Asp?Ile?Gly?Gly?Leu?Asp?Asp?Gln?Ile?Glu?Leu?Ile?Gln?Asp

210 215 220

Ala?Val?Glu?Leu?Pro?Phe?Leu?His?Pro?Glu?Met?Tyr?Arg?Ala?Tyr?Asn

225 230 235 240

Leu?His?Pro?Pro?Lys?Gly?Val?Leu?Leu?Tyr?Gly?Pro?Pro?Gly?Cys?Gly

245 250 255

Lys?Thr?Leu?Ile?Ala?Lys?Ala?Val?Ala?Asn?Ser?Leu?Ala?Asn?Arg?Ile

260 265 270

Gly?Glu?Thr?Gly?Thr?Ser?Tyr?Phe?Ile?Asn?Val?Lys?Gly?Pro

275 280 285

<210>79

<211>735

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(712)

<223>RXA02317

<400>79

gaattttccg?gtgttaaaat?gtgcggtgag?cttggcgttg?gcggaggacc?agtgtgggga?60

gacgtcgaaa?agcgaattca?tggccccatc?ttgccttaaa?atg?gcg?cac?atg?cgc 115

Met?Ala?His?Met?Arg

1 5

tta?ctg?ctg?acc?tcc?ttt?ggc?cat?gat?cat?att?cgg?gat?ttt?gta?cgc 163

Leu?Leu?Leu?Thr?Ser?Phe?Gly?His?Asp?His?Ile?Arg?Asp?Phe?Val?Arg

10 15 20

ggt?acc?gtg?gcg?tat?atc?cct?gat?gcg?acc?agg?ctt?ttt?gct?gat?agt 211

Gly?Thr?Val?Ala?Tyr?Ile?Pro?Asp?Ala?Thr?Arg?Leu?Phe?Ala?Asp?Ser

25 30 35

ccc?gag?gct?gct?cct?ttt?atg?gag?acg?gag?cga?aat?atg?ctg?cgc?gag 259

Pro?Glu?Ala?Ala?Pro?Phe?Met?Glu?Thr?Glu?Arg?Asn?Met?Leu?Arg?Glu

40 45 50

cac?ggc?ttg?agc?att?cgt?gag?ctg?ccg?att?tcc?acg?tcg?act?ccg?gag 307

His?Gly?Leu?Ser?Ile?Arg?Glu?Leu?Pro?Ile?Ser?Thr?Ser?Thr?Pro?Glu

55 60 65

gaa?gtg?gat?cgg?gtg?ctt?ggt?gag?gtt?gat?ggg?gtg?tat?gtg?gcg?ggc 355

Glu?Val?Asp?Arg?Val?Leu?Gly?Glu?Val?Asp?Gly?Val?Tyr?Val?Ala?Gly

70 75 80 85

ggt?gag?act?ttt?gat?ctg?atg?tgg?ctg?ctg?cgt?tcc?aca?ggc?aat?gat 403

Gly?Glu?Thr?Phe?Asp?Leu?Met?Trp?Leu?Leu?Arg?Ser?Thr?Gly?Asn?Asp

90 95 100

gag?gtg?ttg?att?aag?cat?gtt?cgc?gct?ggt?cta?ccg?tat?att?gga?acg 451

Glu?Val?Leu?Ile?Lys?His?Val?Arg?Ala?Gly?Leu?Pro?Tyr?Ile?Gly?Thr

105 110 115

agc?gcc?ggc?gcg?gta?att?gca?ggt?cct?tcg?att?gaa?ccg?atc?agc?ttt 499

Ser?Ala?Gly?Ala?Val?Ile?Ala?Gly?Pro?Ser?Ile?Glu?Pro?Ile?Ser?Phe

120 125 130

ttg?gat?agc?ccc?gat?gtc?gcg?ccg?aat?tta?agc?gac?tat?tca?ggt?cta 547

Leu?Asp?Ser?Pro?Asp?Val?Ala?Pro?Asn?Leu?Ser?Asp?Tyr?Ser?Gly?Leu

135 140 145

ggc?ctg?tgc?gag?cat?gtc?gtg?gtg?ccc?cat?gct?ggt?ggc?acg?atc?ccg 595

Gly?Leu?Cys?Glu?His?Val?Val?Val?Pro?His?Ala?Gly?Gly?Thr?Ile?Pro

150 155 160 165

caa?ttt?ccc?atc?gat?gtg?ttt?gcg?gaa?acc?gtg?cgc?acc?tac?ggc?gcc 643

Gln?Phe?Pro?Ile?Asp?Val?Phe?Ala?Glu?Thr?Val?Arg?Thr?Tyr?Gly?Ala

170 175 180

gaa?ttc?ccg?ctg?gtc?ctg?ctt?aaa?gat?gga?cag?gca?ctg?ctt?atc?gac 691

Glu?Phe?Pro?Leu?Val?Leu?Leu?Lys?Asp?Gly?Gln?Ala?Leu?Leu?Ile?Asp

185 190 195

gac?cac?ggc?gtc?cac?cta?att?taggatggtt?ccccatgagc?acc 735

Asp?His?Gly?Val?His?Leu?Ile

200

<210>80

<211>204

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>80

Met?Ala?His?Met?Arg?Leu?Leu?Leu?Thr?Ser?Phe?Gly?His?Asp?His?Ile

1 5 10 15

Arg?Asp?Phe?Val?Arg?Gly?Thr?Val?Ala?Tyr?Ile?Pro?Asp?Ala?Thr?Arg

20 25 30

Leu?Phe?Ala?Asp?Ser?Pro?Glu?Ala?Ala?Pro?Phe?Met?Glu?Thr?Glu?Arg

35 40 45

Asn?Met?Leu?Arg?Glu?His?Gly?Leu?Ser?Ile?Arg?Glu?Leu?Pro?Ile?Ser

50 55 60

Thr?Ser?Thr?Pro?Glu?Glu?Val?Asp?Arg?Val?Leu?Gly?Glu?Val?Asp?Gly

65 70 75 80

Val?Tyr?Val?Ala?Gly?Gly?Glu?Thr?Phe?Asp?Leu?Met?Trp?Leu?Leu?Arg

85 90 95

Ser?Thr?Gly?Asn?Asp?Glu?Val?Leu?Ile?Lys?His?Val?Arg?Ala?Gly?Leu

100 105 110

Pro?Tyr?Ile?Gly?Thr?Ser?Ala?Gly?Ala?Val?Ile?Ala?Gly?Pro?Ser?Ile

115 120 125

Glu?Pro?Ile?Ser?Phe?Leu?Asp?Ser?Pro?Asp?Val?Ala?Pro?Asn?Leu?Ser

130 135 140

Asp?Tyr?Ser?Gly?Leu?Gly?Leu?Cys?Glu?His?Val?Val?Val?Pro?His?Ala

145 150 155 160

Gly?Gly?Thr?Ile?Pro?Gln?Phe?Pro?Ile?Asp?Val?Phe?Ala?Glu?Thr?Val

165 170 175

Arg?Thr?Tyr?Gly?Ala?Glu?Phe?Pro?Leu?Val?Leu?Leu?Lys?Asp?Gly?Gln

180 185 190

Ala?Leu?Leu?Ile?Asp?Asp?His?Gly?Val?His?Leu?Ile

195 200

<210>81

<211>774

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(751)

<223>RXA02644

<400>81

cgtggggaag?tggagcccac?actgaaaagc?tttgcgaggt?caacatggcc?accaggctag?60

tgaaaatgct?gccggttggc?gagctaagat?gtgagatgct?atg?gca?cat?ctc?acg 115

Met?Ala?His?Leu?Thr

1 5

caa?tac?caa?ctc?cct?cag?gcc?ggt?caa?gtc?ttt?gag?cat?gaa?cta?gag 163

Gln?Tyr?Gln?Leu?Pro?Gln?Ala?Gly?Gln?Val?Phe?Glu?His?Glu?Leu?Glu

10 15 20

atc?aag?cgc?tcg?cga?ttt?ctg?acc?tat?atc?acg?cgt?gtg?caa?gat?cag 211

Ile?Lys?Arg?Ser?Arg?Phe?Leu?Thr?Tyr?Ile?Thr?Arg?Val?Gln?Asp?Gln

25 30 35

gag?cag?gct?cgc?gaa?ttt?att?cac?tcc?atc?aag?gag?ctg?tat?ccg?gat 259

Glu?Gln?Ala?Arg?Glu?Phe?Ile?His?Ser?Ile?Lys?Glu?Leu?Tyr?Pro?Asp

40 45 50

gcg?cgt?cat?cat?tgc?agt?gcc?ttt?att?ttc?cat?gtg?gat?ggc?tca?aat 307

Ala?Arg?His?His?Cys?Ser?Ala?Phe?Ile?Phe?His?Val?Asp?Gly?Ser?Asn

55 60 65

gat?gtg?gag?cgt?tcc?tct?gat?gat?ggc?gaa?cct?tcc?ggt?acc?gcg?gga 355

Asp?Val?Glu?Arg?Ser?Ser?Asp?Asp?Gly?Glu?Pro?Ser?Gly?Thr?Ala?Gly

70 75 80 85

aaa?ccc?atg?cta?gag?gcg?ttg?cgt?ggc?tcg?gga?atg?aaa?gat?att?gcc 403

Lys?Pro?Met?Leu?Glu?Ala?Leu?Arg?Gly?Ser?Gly?Met?Lys?Asp?Ile?Ala

90 95 100

gct?gtg?gtg?gtg?cgt?tat?ttc?ggt?ggc?gta?aaa?ctg?ggc?act?ggc?gga 451

Ala?Val?Val?Val?Arg?Tyr?Phe?Gly?Gly?Val?Lys?Leu?Gly?Thr?Gly?Gly

105 110 115

tta?gtt?aat?gcc?tac?acc?aac?gcg?gtg?acg?gag?ctt?cta?cct?gag?gtt 499

Leu?Val?Asn?Ala?Tyr?Thr?Asn?Ala?Val?Thr?Glu?Leu?Leu?Pro?Glu?Val

120 125 130

ttg?caa?gtc?acc?cgc?tct?gtt?cgg?gag?att?ttc?aag?att?gac?ctt?ccg 547

Leu?Gln?Val?Thr?Arg?Ser?Val?Arg?Glu?Ile?Phe?Lys?Ile?Asp?Leu?Pro

135 140 145

cat?tct?gat?gcg?ggg?cgc?att?gaa?gcg?aat?ctg?cgc?ggc?atg?ggc?atc 595

His?Ser?Asp?Ala?Gly?Arg?Ile?Glu?Ala?Asn?Leu?Arg?Gly?Met?Gly?Ile

150 155 160 165

atc?att?act?gac?act?gaa?tat?ggt?gca?gaa?gtc?aca?tac?acc?ttg?gct 643

Ile?Ile?Thr?Asp?Thr?Glu?Tyr?Gly?Ala?Glu?Val?Thr?Tyr?Thr?Leu?Ala

170 175 180

tta?ttg?cct?ggt?gaa?cag?gct?gcg?gtg?gaa?tct?caa?ttg?tca?tcc?atg 691

Leu?Leu?pro?Gly?Glu?Gln?Ala?Ala?Val?Glu?Ser?Gln?Leu?Ser?Ser?Met

185 190 195

atg?ggt?gca?gaa?att?gaa?ttg?aaa?gaa?tcc?ggg?cac?atg?tgg?gtg?gaa 739

Met?Gly?Ala?Glu?Ile?Glu?Leu?Lys?Glu?Ser?Gly?His?Met?Trp?Val?Glu

200 205 210

tcc?ccg?agt?gac?tagtgcggtg?taagagcact?aga 774

Ser?Pro?Ser?Asp

215

<2l0>82

<211>217

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>82

Met?Ala?His?Leu?Thr?Gln?Tyr?Gln?Leu?Pro?Gln?Ala?Gly?Gln?Val?Phe

1 5 10 15

Glu?His?Glu?Leu?Glu?Ile?Lys?Arg?Ser?Arg?Phe?Leu?Thr?Tyr?Ile?Thr

20 25 30

Arg?Val?Gln?Asp?Gln?Glu?Gln?Ala?Arg?Glu?Phe?Ile?His?Ser?Ile?Lys

35 40 45

Glu?Leu?Tyr?Pro?Asp?Ala?Arg?His?His?Cys?Ser?Ala?Phe?Ile?Phe?His

50 55 60

Val?Asp?Gly?Ser?Asn?Asp?Val?Glu?Arg?Ser?Ser?Asp?Asp?Gly?Glu?Pro

65 70 75 80

Ser?Gly?Thr?Ala?Gly?Lys?Pro?Met?Leu?Glu?Ala?Leu?Arg?Gly?Ser?Gly

85 90 95

Met?Lys?Asp?Ile?Ala?Ala?Val?Val?Val?Arg?Tyr?Phe?Gly?Gly?Val?Lys

100 105 110

Leu?Gly?Thr?Gly?Gly?Leu?Val?Asn?Ala?Tyr?Thr?Asn?Ala?Val?Thr?Glu

115 120 125

Leu?Leu?Pro?Glu?Val?Leu?Gln?Val?Thr?Arg?Ser?Val?Arg?Glu?Ile?Phe

130 135 140

Lys?Ile?Asp?Leu?Pro?His?Ser?Asp?Ala?Gly?Arg?Ile?Glu?Ala?Asn?Leu

145 150 155 160

Arg?Gly?Met?Gly?Ile?Ile?Ile?Thr?Asp?Thr?Glu?Tyr?Gly?Ala?Glu?Val

165 170 175

Thr?Tyr?Thr?Leu?Ala?Leu?Leu?Pro?Gly?Glu?Gln?Ala?Ala?Val?Glu?Ser

180 185 190

Gln?Leu?Ser?Ser?Met?Met?Gly?Ala?Glu?Ile?Glu?Leu?Lys?Glu?Ser?Gly

195 200 205

His?Met?Trp?Val?Glu?Ser?Pro?Ser?Asp

210 215

<210>83

<211>1411

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1411)

<223>RXN02820

<400>83

caacgaaaca?aatgcaagcc?cccaatcatg?ggtttctacc?aattaaattt?tctttcagaa?60

aatatctccc?cacataaaag?ttccttgata?ggctcgagag?atg?aaa?gtg?acc?caa 115

Met?Lys?Val?Thr?Gln

1 5

agc?aca?ttc?ctt?aaa?tcg?gta?gct?gcg?ttc?act?gtc?gca?gcc?tta?acc 163

Ser?Thr?Phe?Leu?Lys?Ser?Val?Ala?Ala?Phe?Thr?Val?Ala?Ala?Leu?Thr

10 15 20

ctg?acc?atc?tct?tcg?tgt?tcc?agc?ggt?gaa?gac?acc?tcc?gca?agc?tcc 211

Leu?Thr?Ile?Ser?Ser?Cys?Ser?Ser?Gly?Glu?Asp?Thr?Ser?Ala?Ser?Ser

25 30 35

acg?gat?act?gaa?aac?tcc?tca?acc?caa?gca?gca?gcg?tct?ccc?cca?ctt 259

Thr?Asp?Thr?Glu?Asn?Ser?Ser?Thr?Gln?Ala?Ala?Ala?Ser?Pro?Pro?Leu

40 45 50

gcg?cct?tgt?gaa?ctt?ccc?gcc?gac?gct?tct?gct?gaa?gag?gaa?gta?gaa 307

Ala?Pro?Cys?Glu?Leu?Pro?Ala?Asp?Ala?Ser?Ala?Glu?Glu?Glu?Val?Glu

55 60 65

ggc?act?cac?aca?ggt?gaa?gat?att?tct?gtt?gcc?ccg?gaa?atc?ggt?acc 355

Gly?Thr?His?Thr?Gly?Glu?Asp?Ile?Ser?Val?Ala?Pro?Glu?Ile?Gly?Thr

70 75 80 85

ggc?tac?cgc?gag?ggc?atg?acc?cct?gtt?caa?acc?caa?ggt?tat?gcg?gtg 403

Gly?Tyr?Arg?Glu?Gly?Met?Thr?Pro?Val?Gln?Thr?Gln?Gly?Tyr?Ala?Val

90 95 100

gca?act?gca?aac?ccc?atc?gct?tct?gaa?gca?gcc?tgc?gcg?gtg?tta?aga 451

Ala?Thr?Ala?Asn?Pro?Ile?Ala?Ser?Glu?Ala?Ala?Cys?Ala?Val?Leu?Arg

105 110 115

gaa?ggc?ggc?act?gca?gct?gat?gct?ctt?gtc?acc?gcg?cag?ttt?gtt?ttg 499

Glu?Gly?Gly?Thr?Ala?Ala?Asp?Ala?Leu?Val?Thr?Ala?Gln?Phe?Val?Leu

120 125 130

gga?ctg?acg?gaa?ccg?cag?tcg?tct?ggc?ctt?ggt?ggt?ggc?gga?tac?att 547

Gly?Leu?Thr?Glu?Pro?Gln?Ser?Ser?Gly?Leu?Gly?Gly?Gly?Gly?Tyr?Ile

135 140 145

ctg?tac?tac?gac?gcc?gaa?gcc?aat?gcg?gtg?aca?gcc?att?gat?ggc?cgt 595

Leu?Tyr?Tyr?Asp?Ala?Glu?Ala?Asn?Ala?Val?Thr?Ala?Ile?Asp?Gly?Arg

150 155 160 165

gaa?aca?gcg?cca?gtt?gct?gct?gat?gaa?aac?tat?ctc?att?cat?gtt?tct 643

Glu?Thr?Ala?Pro?Val?Ala?Ala?Asp?Glu?Asn?Tyr?Leu?Ile?His?Val?Ser

170 175 180

gca?gag?gat?caa?acg?gca?cct?gtt?cct?gat?gcc?cga?cgt?tcc?ggc?agg 691

Ala?Glu?Asp?Gln?Thr?Ala?Pro?Val?Pro?Asp?Ala?Arg?Arg?Ser?Gly?Arg

185 190 195

tca?att?ggt?gtg?cca?gga?atc?gtg?gca?gcc?ctt?gga?cag?ctg?cat?gat 739

Ser?Ile?Gly?Val?Pro?Gly?Ile?Val?Ala?Ala?Leu?Gly?Gln?Leu?His?Asp

200 205 210

tca?ttc?gga?aag?acc?tcc?tgg?cag?gac?gtg?ctg?aca?act?ccg?cag?cag 787

Ser?Phe?Gly?Lys?Thr?Ser?Trp?Gln?Asp?Val?Leu?Thr?Thr?Pro?Gln?Gln

215 220 225

ctc?gca?act?gat?ggt?ttt?tcc?atc?agc?cct?cgc?atg?tca?gca?tca?att 835

Leu?Ala?Thr?Asp?Gly?Phe?Ser?Ile?Ser?Pro?Arg?Met?Ser?Ala?Ser?Ile

230 235 240 245

gct?aac?tcc?gct?gag?gat?ctc?tcc?cac?gat?ccg?gaa?gct?gcc?gca?tat 883

Ala?Asn?Ser?Ala?Glu?Asp?Leu?Ser?His?Asp?Pro?Glu?Ala?Ala?Ala?Tyr

250 255 260

ttc?ctt?gat?gaa?aac?ggt?gat?gcg?aag?gca?ccc?ggc?aca?ctt?tta?caa 931

Phe?Leu?Asp?Glu?Asn?Gly?Asp?Ala?Lys?Ala?Pro?Gly?Thr?Leu?Leu?Gln

265 270 275

aac?cct?gac?tat?gca?gaa?acg?att?cgt?ctc?atc?tct?gaa?ggt?ggc?ccc 979

Asn?Pro?Asp?Tyr?Ala?Glu?Thr?Ile?Arg?Leu?Ile?Ser?Glu?Gly?Gly?Pro

280 285 290

gat?gcg?ttc?tac?acg?ggt?gag?att?gca?gca?gac?atc?gtg?gaa?cgc?gcc 1027

Asp?Ala?Phe?Tyr?Thr?Gly?Glu?Ile?Ala?Ala?Asp?Ile?Val?Glu?Arg?Ala

295 300 305

acc?cgt?gag?gtt?gac?ggt?ttc?aca?cca?tca?ctg?atg?agc?acg?gca?gat 1075

Thr?Arg?Glu?Val?Asp?Gly?Phe?Thr?Pro?Ser?Leu?Met?Ser?Thr?Ala?Asp

310 315 320 325

ttg?gct?gcc?tac?act?ccg?gaa?act?cgt?gaa?gct?ttg?tgt?gct?ccc?tac 1123

Leu?Ala?Ala?Tyr?Thr?Pro?Glu?Thr?Arg?Glu?Ala?Leu?Cys?Ala?Pro?Tyr

330 335 340

cgc?gac?aag?att?gtt?tgt?ggc?atg?cca?ccg?tca?tca?tcg?ggt?ggc?gtc 1171

Arg?Asp?Lys?Ile?Val?Cys?Gly?Met?Pro?Pro?Ser?Ser?Ser?Gly?Gly?Val

345 350 355

aca?gtg?atg?gaa?acc?ctg?ggt?atc?ttg?aac?aac?ttt?gat?ctc?gcc?caa 1219

Thr?Val?Met?Glu?Thr?Leu?Gly?Ile?Leu?Asn?Ash?Phe?Asp?Leu?Ala?Gln

360 365 370

tac?cca?ccc?act?gag?gtt?ggt?ttg?gat?ggc?gga?ttg?cca?aat?gcg?gaa 1267

Tyr?Pro?Pro?Thr?Glu?Val?Gly?Leu?Asp?Gly?Gly?Leu?Pro?Asn?Ala?Glu

375 380 385

gct?gtt?cac?ctg?att?tca?gag?gct?gag?cgc?ctg?gct?tat?gct?gat?cgc 1315

Ala?Val?His?Leu?Ile?Ser?Glu?Ala?Glu?Arg?Leu?Ala?Tyr?Ala?Asp?Arg

390 395 400 405

gat?gct?tac?atc?ggt?gat?cct?gct?ttc?gtg?gaa?gtt?cca?gca?ggt?ggt 1363

Asp?Ala?Tyr?Ile?Gly?Asp?Pro?Ala?Phe?Val?Glu?Val?Pro?Ala?Gly?Gly

410 415 420

gtc?caa?cag?tgg?atc?aac?cat?gtc?cac?acg?ggc?gaa?cac?tcc?aaa?ctt l411

Val?Gln?Gln?Trp?Ile?Asn?His?Val?His?Thr?Gly?Glu?His?Ser?Lys?Leu

425 430 435

<210>84

<211>437

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>84

Met?Lys?Val?Thr?Gln?Ser?Thr?Phe?Leu?Lys?Ser?Val?Ala?Ala?Phe?Thr

1 5 10 15

Val?Ala?Ala?Leu?Thr?Leu?Thr?Ile?Ser?Ser?Cys?Ser?Ser?Gly?Glu?Asp

20 25 30

Thr?Ser?Ala?Ser?Ser?Thr?Asp?Thr?Glu?Asn?Ser?Ser?Thr?Gln?Ala?Ala

35 40 45

Ala?Ser?Pro?Pro?Leu?Ala?Pro?Cys?Glu?Leu?Pro?Ala?Asp?Ala?Ser?Ala

50 55 60

Glu?Glu?Glu?Val?Glu?Gly?Thr?His?Thr?Gly?Glu?Asp?Ile?Ser?Val?Ala

65 70 75 80

Pro?Glu?Ile?Gly?Thr?Gly?Tyr?Arg?Glu?Gly?Met?Thr?Pro?Val?Gln?Thr

85 90 95

Gln?Gly?Tyr?Ala?Val?Ala?Thr?Ala?Asn?Pro?Ile?Ala?Ser?Glu?Ala?Ala

100 105 110

Cys?Ala?Val?Leu?Arg?Glu?Gly?Gly?Thr?Ala?Ala?Asp?Ala?Leu?Val?Thr

115 120 125

Ala?Gln?Phe?Val?Leu?Gly?Leu?Thr?Glu?Pro?Gln?Ser?Ser?Gly?Leu?Gly

130 135 140

Gly?Gly?Gly?Tyr?Ile?Leu?Tyr?Tyr?Asp?Ala?Glu?Ala?Asn?Ala?Val?Thr

145 150 155 160

Ala?Ile?Asp?Gly?Arg?Glu?Thr?Ala?Pro?Val?Ala?Ala?Asp?Glu?Asn?Tyr

165 170 175

Leu?Ile?His?Val?Ser?Ala?Glu?Asp?Gln?Thr?Ala?Pro?Val?Pro?Asp?Ala

180 185 190

Arg?Arg?Ser?Gly?Arg?Ser?Ile?Gly?Val?Pro?Gly?Ile?Val?Ala?Ala?Leu

195 200 205

Gly?Gln?Leu?His?Asp?Ser?Phe?Gly?Lys?Thr?Ser?Trp?Gln?Asp?Val?Leu

210 215 220

Thr?Thr?Pro?Gln?Gln?Leu?Ala?Thr?Asp?Gly?Phe?Ser?Ile?Ser?Pro?Arg

225 230 235 240

Met?Ser?Ala?Ser?Ile?Ala?Asn?Ser?Ala?Glu?Asp?Leu?Ser?His?Asp?Pro

245 250 255

Glu?Ala?Ala?Ala?Tyr?Phe?Leu?Asp?Glu?Asn?Gly?Asp?Ala?Lys?Ala?Pro

260 265 270

Gly?Thr?Leu?Leu?Gln?Asn?Pro?Asp?Tyr?Ala?Glu?Thr?Ile?Arg?Leu?Ile

275 280 285

Ser?Glu?Gly?Gly?Pro?Asp?Ala?Phe?Tyr?Thr?Gly?Glu?Ile?Ala?Ala?Asp

290 295 300

Ile?Val?Glu?Arg?Ala?Thr?Arg?Glu?Val?Asp?Gly?Phe?Thr?Pro?Ser?Leu

305 310 315 320

Met?Ser?Thr?Ala?Asp?Leu?Ala?Ala?Tyr?Thr?Pro?Glu?Thr?Arg?Glu?Ala

325 330 335

Leu?Cys?Ala?Pro?Tyr?Arg?Asp?Lys?Ile?Val?Cys?Gly?Met?Pro?Pro?Ser

340 345 350

Ser?Ser?Gly?Gly?Val?Thr?Val?Met?Glu?Thr?Leu?Gly?Ile?Leu?Asn?Asn

355 360 365

Phe?Asp?Leu?Ala?Gln?Tyr?Pro?Pro?Thr?Glu?Val?Gly?Leu?Asp?Gly?Gly

370 375 380

Leu?Pro?Asn?Ala?Glu?Ala?Val?His?Leu?Ile?Ser?Glu?Ala?Glu?Arg?Leu

385 390 395 400

Ala?Tyr?Ala?Asp?Arg?Asp?Ala?Tyr?Ile?Gly?Asp?Pro?Ala?Phe?Val?Glu

405 410 415

Val?Pro?Ala?Gly?Gly?Val?Gln?Gln?Trp?Ile?Asn?His?Val?His?Thr?Gly

420 425 430

Glu?His?Ser?Lys?Leu

435

<210>85

<211>507

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(507)

<223>FRXA02820

<400>85

gct?aac?tcc?gct?gag?gat?ctc?tcc?cac?gat?ccg?gaa?gct?gcc?gca?tat 48

Ala?Asn?Ser?Ala?Glu?Asp?Leu?Ser?His?Asp?Pro?Glu?Ala?Ala?Ala?Tyr

1 5 10 15

ttc?ctt?gat?gaa?aac?ggt?gat?gcg?aag?gca?ccc?ggc?aca?ctt?tta?caa 96

Phe?Leu?Asp?Glu?Asn?Gly?Asp?Ala?Lys?Ala?Pro?Gly?Thr?Leu?Leu?Gln

20 25 30

aac?cct?gac?tat?gca?gaa?acg?att?cgt?ctc?atc?tct?gaa?ggt?ggc?ccc 144

Asn?Pro?Asp?Tyr?Ala?Glu?Thr?Ile?Arg?Leu?Ile?Ser?Glu?Gly?Gly?Pro

35 40 45

gat?gcg?ttc?tac?acg?ggt?gag?att?gca?gca?gac?atc?gtg?gaa?cgc?gcc 192

Asp?Ala?Phe?Tyr?Thr?Gly?Glu?Ile?Ala?Ala?Asp?Ile?Val?Glu?Arg?Ala

50 55 60

acc?cgt?gag?gtt?gac?ggt?ttc?aca?cca?tca?ctg?atg?agc?acg?gca?gat 240

Thr?Arg?Glu?Val?Asp?Gly?Phe?Thr?Pro?Ser?Leu?Met?Ser?Thr?Ala?Asp

65 70 75 80

ttg?gct?gcc?tac?act?ccg?gaa?act?cgt?gaa?gct?ttg?tgt?gct?ccc?tac 288

Leu?Ala?Ala?Tyr?Thr?Pro?Glu?Thr?Arg?Glu?Ala?Leu?Cys?Ala?Pro?Tyr

85 90 95

cgc?gac?aag?att?gtt?tgt?ggc?atg?cca?ccg?tca?tca?tcg?ggt?ggc?gtc 336

Arg?Asp?Lys?Ile?Val?Cys?Gly?Met?Pro?Pro?Ser?Ser?Ser?Gly?Gly?Val

100 105 110

aca?gtg?atg?gaa?acc?ctg?ggt?atc?ttg?aac?aac?ttt?gat?ctc?gcc?caa 384

Thr?Val?Met?Glu?Thr?Leu?Gly?Ile?Leu?Asn?Asn?Phe?Asp?Leu?Ala?Gln

115 120 125

tac?cca?ccc?act?gag?gtt?ggt?ttg?gat?ggc?gga?ttg?cca?aat?gcg?gaa 432

Tyr?Pro?Pro?Thr?Glu?Val?Gly?Leu?Asp?Gly?Gly?Leu?Pro?Asn?Ala?Glu

130 135 140

gct?gtt?cac?ctg?att?tca?gag?gct?gag?cgc?ctg?gct?tat?gct?gat?cgc 480

Ala?Val?His?Leu?Ile?Ser?Glu?Ala?Glu?Arg?Leu?Ala?Tyr?Ala?Asp?Arg

145 150 155 160

gat?gct?tac?atc?ggt?gat?cct?gct?ttc 507

Asp?Ala?Tyr?Ile?Gly?Asp?Pro?Ala?Phe

165

<210>86

<211>169

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>86

Ala?Asn?Ser?Ala?Glu?Asp?Leu?Ser?His?Asp?Pro?Glu?Ala?Ala?Ala?Tyr

1 5 10 15

Phe?Leu?Asp?Glu?Asn?Gly?Asp?Ala?Lys?Ala?Pro?Gly?Thr?Leu?Leu?Gln

20 25 30

Asn?Pro?Asp?Tyr?Ala?Glu?Thr?Ile?Arg?Leu?Ile?Ser?Glu?Gly?Gly?Pro

35 40 45

Asp?Ala?Phe?Tyr?Thr?Gly?Glu?Ile?Ala?Ala?Asp?Ile?Val?Glu?Arg?Ala

50 55 60

Thr?Arg?Glu?Val?Asp?Gly?Phe?Thr?Pro?Ser?Leu?Met?Ser?Thr?Ala?Asp

65 70 75 80

Leu?Ala?Ala?Tyr?Thr?Pro?Glu?Thr?Arg?Glu?Ala?Leu?Cys?Ala?Pro?Tyr

85 90 95

Arg?Asp?Lys?Ile?Val?Cys?Gly?Met?Pro?Pro?Ser?Ser?Ser?Gly?Gly?Val

100 105 110

Thr?Val?Met?Glu?Thr?Leu?Gly?Ile?Leu?Asn?Asn?Phe?Asp?Leu?Ala?Gln

115 120 125

Tyr?Pro?Pro?Thr?Glu?Val?Gly?Leu?Asp?Gly?Gly?Leu?Pro?Asn?Ala?Glu

130 135 140

Ala?Val?His?Leu?Ile?Ser?Glu?Ala?Glu?Arg?Leu?Ala?Tyr?Ala?Asp?Arg

145 150 155 160

Asp?Ala?Tyr?Ile?Gly?Asp?Pro?Ala?Phe

165

<210>87

<211>604

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(604)

<223>FRXA02000

<400>87

caacgaaaca?aatgcaagcc?cccaatcatg?ggtttctacc?aattaaattt?tctttcagaa?60

aatatctccc?cacataaaag?ttccttgata?ggctcgagag?atg?aaa?gtg?acc?caa 115

Met?Lys?Val?Thr?Gln

1 5

agc?aca?ttc?ctt?aaa?tcg?gta?gct?gcg?ttc?act?gtc?gca?gcc?tta?acc 163

Ser?Thr?Phe?Leu?Lys?Ser?Val?Ala?Ala?Phe?Thr?Val?Ala?Ala?Leu?Thr

10 15 20

ctg?acc?atc?tct?tcg?tgt?tcc?agc?ggt?gaa?gac?acc?tcc?gca?agc?tcc 211

Leu?Thr?Ile?Ser?Ser?Cys?Ser?Ser?Gly?Glu?Asp?Thr?Ser?Ala?Ser?Ser

25 30 35

acg?gat?act?gaa?aac?tcc?tca?acc?caa?gca?gca?gcg?tct?ccc?cca?ctt 259

Thr?Asp?Thr?Glu?Asn?Ser?Ser?Thr?Gln?Ala?Ala?Ala?Ser?Pro?Pro?Leu

40 45 50

gcg?cct?tgt?gaa?ctt?ccc?gcc?gac?gct?tct?gct?gaa?gag?gaa?gta?gaa 307

Ala?Pro?Cys?Glu?Leu?Pro?Ala?Asp?Ala?Ser?Ala?Glu?Glu?Glu?Val?Glu

55 60 65

ggc?act?cac?aca?ggt?gaa?gat?att?tct?gtt?gcc?ccg?gaa?atc?ggt?acc 355

Gly?Thr?His?Thr?Gly?Glu?Asp?Ile?Ser?Val?Ala?Pro?Glu?Ile?Gly?Thr

70 75 80 85

ggc?tac?cgc?gag?ggc?atg?acc?cct?gtt?caa?acc?caa?ggt?tat?gcg?gtg 403

Gly?Tyr?Arg?Glu?Gly?Met?Thr?Pro?Val?Gln?Thr?Gln?Gly?Tyr?Ala?Val

90 95 100

gca?act?gca?aac?ccc?atc?gct?tct?gaa?gca?gcc?tgc?gcg?gtg?tta?aga 451

Ala?Thr?Ala?Asn?Pro?Ile?Ala?Ser?Glu?Ala?Ala?Cys?Ala?Val?Leu?Arg

105 110 115

gaa?ggc?ggc?act?gca?gct?gat?gct?ctt?gtc?acc?gcg?cag?ttt?gtt?ttg 499

Glu?Gly?Gly?Thr?Ala?Ala?Asp?Ala?Leu?Val?Thr?Ala?Gln?Phe?Val?Leu

120 125 130

gga?ctg?acg?gaa?ccg?cag?tcg?tct?ggc?ctt?ggt?ggt?ggc?gga?tac?att 547

Gly?Leu?Thr?Glu?Pro?Gln?Ser?Ser?Gly?Leu?Gly?Gly?Gly?Gly?Tyr?Ile

135 140 145

ctg?tac?tac?gac?gcc?gaa?gcc?aat?gcg?gtg?aca?gcc?att?gat?ggc?cgt 595

Leu?Tyr?Tyr?Asp?Ala?Glu?Ala?Asn?Ala?Val?Thr?Ala?Ile?Asp?Gly?Arg

150 155 160 165

Glu?Thr?Ala 604

<210>88

<211>168

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>88

Met?Lys?Val?Thr?Gln?Ser?Thr?Phe?Leu?Lys?Ser?Val?Ala?Ala?Phe?Thr

1 5 10 15

Val?Ala?Ala?Leu?Thr?Leu?Thr?Ile?Ser?Ser?Cys?Ser?Ser?Gly?Glu?Asp

20 25 30

Thr?Ser?Ala?Ser?Ser?Thr?Asp?Thr?Glu?Asn?Ser?Ser?Thr?Gln?Ala?Ala

35 40 45

Ala?Ser?Pro?Pro?Leu?Ala?Pro?Cys?Glu?Leu?Pro?Ala?Asp?Ala?Ser?Ala

50 55 60

Glu?Glu?Glu?Val?Glu?Gly?Thr?His?Thr?Gly?Glu?Asp?Ile?Ser?Val?Ala

65 70 75 80

Pro?Glu?Ile?Gly?Thr?Gly?Tyr?Arg?Glu?Gly?Met?Thr?Pro?Val?Gln?Thr

85 90 95

Gln?Gly?Tyr?Ala?Val?Ala?Thr?Ala?Asn?Pro?Ile?Ala?Ser?Glu?Ala?Ala

100 105 110

Cys?Ala?Val?Leu?Arg?Glu?Gly?Gly?Thr?Ala?Ala?Asp?Ala?Leu?Val?Thr

115 120 125

Ala?Gln?Phe?Val?Leu?Gly?Leu?Thr?Glu?Pro?Gln?Ser?Ser?Gly?Leu?Gly

130 135 140

Gly?Gly?Gly?Tyr?Ile?Leu?Tyr?Tyr?Asp?Ala?Glu?Ala?Asn?Ala?Val?Thr

145 150 155 160

Ala?Ile?Asp?Gly?Arg?Glu?Thr?Ala

165

<210>89

<211>824

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(801)

<223>RXN03178

<400>89

ccc?acc?acc?gtg?gtc?acg?ggc?acg?atg?gaa?gcc?gcc?aac?atc?gag?ggc 48

Pro?Thr?Thr?Val?Val?Thr?Gly?Thr?Met?Glu?Ala?Ala?Asn?Ile?Glu?Gly

1 5 10 15

tcc?cgc?gtg?ggt?gtc?ggc?gag?gcc?ggc?cag?tat?acc?gtt?gat?cag?ctg 96

Ser?Arg?Val?Gly?Val?Gly?Glu?Ala?Gly?Gln?Tyr?Thr?Val?Asp?Gln?Leu

20 25 30

ctg?cac?ggt?ctt?ctt?tta?gcc?agc?ggt?aac?gat?gcg?gcg?tat?atg?ttg 144

Leu?His?Gly?Leu?Leu?Leu?Ala?Ser?Gly?Asn?Asp?Ala?Ala?Tyr?Met?Leu

35 40 45

gct?cag?gaa?ctt?ggt?ggg?gat?caa?gca?acc?ctg?gag?aaa?gta?aac?gcg 192

Ala?Gln?Glu?Leu?Gly?Gly?Asp?Gln?Ala?Thr?Leu?Glu?Lys?Val?Asn?Ala

50 55 60

ctg?gcc?aag?gag?ttg?ggc?act?caa?gac?acc?ttc?gtt?gcc?act?tat?tcc 240

Leu?Ala?Lys?Glu?Leu?Gly?Thr?Gln?Asp?Thr?Phe?Val?Ala?Thr?Tyr?Ser

65 70 75 80

ggt?ttg?gat?gcg?ccg?gga?atg?tcg?acc?tcc?gca?tac?gac?atg?tca?ttg 288

Gly?Leu?Asp?Ala?Pro?Gly?Met?Ser?Thr?Ser?Ala?Tyr?Asp?Met?Ser?Leu

85 90 95

att?tat?cag?cat?gcg?tgg?cag?aac?ccg?gtt?ttc?gag?tcg?att?atc?tcc 336

Ile?Tyr?Gln?His?Ala?Trp?Gln?Asn?Pro?Val?Phe?Glu?Ser?Ile?Ile?Ser

100 105 110

acc?gat?cac?att?gat?ttc?cct?ggt?tgg?ggc?gac?aat?gag?ggt?ttc?caa 384

Thr?Asp?His?Ile?Asp?Phe?Pro?Gly?Trp?Gly?Asp?ASn?Glu?Gly?Phe?Gln

115 120 125

gtc?tgg?aac?gat?aac?gcc?ttg?ttc?atg?aac?gat?cct?gat?ggc?atc?ggc 432

Val?Trp?Asn?Asp?Asn?Ala?Leu?Phe?Met?Asn?Asp?Pro?Asp?Gly?Ile?Gly

130 135 140

ggc?aag?acc?ggc?tac?acc?gac?gac?gcg?aac?cac?acc?ttt?gtc?ggc?ggt 480

Gly?Lys?Thr?Gly?Tyr?Thr?Asp?Asp?Ala?Asn?His?Thr?Phe?Val?Gly?Gly

145 150 155 160

ctc?gat?cgg?ggt?ggt?cgc?cgc?ctc?gcc?gcc?gta?ctc?ttg?gat?tcc?acc 528

Leu?Asp?Arg?Gly?Gly?Arg?Arg?Leu?Ala?Ala?Val?Leu?Leu?Asp?Ser?Thr

165 170 175

gtc?agc?gac?att?cgt?ccg?tgg?gaa?caa?gca?cga?ttg?ctt?atc?gac?gcc 576

Val?Ser?Asp?Ile?Arg?Pro?Trp?Glu?Gln?Ala?Arg?Leu?Leu?Ile?Asp?Ala

180 185 190

tcc?ctc?ccc?atc?acg?ccg?ggg?tcc?ggc?gtg?ggc?cag?ctg?ggc?tcc?ggc 624

Ser?Leu?Pro?Ile?Thr?Pro?Gly?Ser?Gly?Val?Gly?Gln?Leu?Gly?Ser?Gly

195 200 205

agc?gcg?aac?gat?gtg?gca?ccg?gcg?acc?cca?gaa?tta?cca?gaa?ccc?acc 672

Ser?Ala?Asn?Asp?Val?Ala?Pro?Ala?Thr?Pro?Glu?Leu?Pro?Glu?Pro?Thr

210 215 220

gac?aac?ctg?act?tca?ggt?gag?ggt?ggg?tcg?cag?aac?acg?ctt?ctt?aag 720

Asp?Asn?Leu?Thr?Ser?Gly?Glu?Gly?Gly?Ser?Gln?Asn?Thr?Leu?Leu?Lys

225 230 235 240

ctc?gtg?gtg?ccc?atc?gga?atc?atc?gtg?ctg?ttg?cta?atc?gcc?gca?cta 768

Leu?Val?Val?Pro?Ile?Gly?Ile?Ile?Val?Leu?Leu?Leu?Ile?Ala?Ala?Leu

245 250 255

gcg?tgg?aca?ttc?aga?tct?ccc?aag?aaa?aag?aac?taggtgttct?tcttcacgac?821

Ala?Trp?Thr?Phe?Arg?Ser?Pro?Lys?Lys?Lys?Asn

260 265

ctc 824

<210>90

<211>267

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>90

Pro?Thr?Thr?Val?Val?Thr?Gly?Thr?Met?Glu?Ala?Ala?Asn?Ile?Glu?Gly

1 5 10 15

Ser?Arg?Val?Gly?Val?Gly?Glu?Ala?Gly?Gln?Tyr?Thr?Val?Asp?Gln?Leu

20 25 30

Leu?His?Gly?Leu?Leu?Leu?Ala?Ser?Gly?Asn?Asp?Ala?Ala?Tyr?Met?Leu

35 40 45

Ala?Gln?Glu?Leu?Gly?Gly?Asp?Gln?Ala?Thr?Leu?Glu?Lys?Val?Asn?Ala

50 55 60

Leu?Ala?Lys?Glu?Leu?Gly?Thr?Gln?Asp?Thr?Phe?Val?Ala?Thr?Tyr?Ser

65 70 75 80

Gly?Leu?Asp?Ala?Pro?Gly?Met?Ser?Thr?Ser?Ala?Tyr?Asp?Met?Ser?Leu

85 90 95

Ile?Tyr?Gln?His?Ala?Trp?Gln?Asn?Pro?Val?Phe?Glu?Ser?Ile?Ile?Ser

100 105 110

Thr?Asp?His?Ile?Asp?Phe?Pro?Gly?Trp?Gly?Asp?Asn?Glu?Gly?Phe?Gln

115 120 125

Val?Trp?Asn?Asp?Asn?Ala?Leu?Phe?Met?Asn?Asp?Pro?Asp?Gly?Ile?Gly

130 135 140

Gly?Lys?Thr?Gly?Tyr?Thr?Asp?Asp?Ala?Asn?His?Thr?Phe?Val?Gly?Gly

145 150 155 160

Leu?Asp?Arg?Gly?Gly?Arg?Arg?Leu?Ala?Ala?Val?Leu?Leu?Asp?Ser?Thr

165 170 175

Val?Ser?Asp?Ile?Arg?Pro?Trp?Glu?Gln?Ala?Arg?Leu?Leu?Ile?Asp?Ala

180 185 190

Ser?Leu?Pro?Ile?Thr?Pro?Gly?Ser?Gly?Val?Gly?Gln?Leu?Gly?Ser?Gly

195 200 205

Ser?Ala?Asn?Asp?Val?Ala?Pro?Ala?Thr?Pro?Glu?Leu?Pro?Glu?Pro?Thr

210 215 220

Asp?Asn?Leu?Thr?Ser?Gly?Glu?Gly?Gly?Ser?Gln?Asn?Thr?Leu?Leu?Lys

225 230 235 240

Leu?Val?Val?Pro?Ile?Gly?Ile?Ile?Val?Leu?Leu?Leu?Ile?Ala?Ala?Leu

245 250 255

Ala?Trp?Thr?Phe?Arg?Ser?Pro?Lys?Lys?Lys?Asn

260 265

<210>91

<211>749

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(726)

<223>FRXA02859

<400>91

cag?tat?acc?gtt?gat?cag?ctg?ctg?cac?ggt?ctt?ctt?tta?gcc?agc?ggt 48

Gln?Tyr?Thr?Val?Asp?Gln?Leu?Leu?His?Gly?Leu?Leu?Leu?Ala?Ser?Gly

1 5 10 15

aac?gat?gcg?gcg?tat?ctg?ttg?gct?cag?gaa?ctt?ggt?ggg?gat?caa?gca 96

Asn?Asp?Ala?Ala?Tyr?Leu?Leu?Ala?Gln?Glu?Leu?Gly?Gly?Asp?Gln?Ala

20 25 30

acc?ctg?gag?aaa?gta?aac?gcg?ctg?gcc?aag?gag?ttg?ggc?act?caa?gac 144

Thr?Leu?Glu?Lys?Val?Asn?Ala?Leu?Ala?Lys?Glu?Leu?Gly?Thr?Gln?Asp

35 40 45

acc?ttc?gtt?gcc?act?tat?tcc?ggt?ttg?gat?gcg?ccg?gga?atg?tcg?acc 192

Thr?Phe?Val?Ala?Thr?Tyr?Ser?Gly?Leu?Asp?Ala?Pro?Gly?Met?Ser?Thr

50 55 60

tcc?gca?tac?gac?atg?tca?ttg?att?tat?cag?cat?gcg?tgg?cag?aac?ccg 240

Ser?Ala?Tyr?Asp?Met?Ser?Leu?Ile?Tyr?Gln?His?Ala?Trp?Gln?Asn?Pro

65 70 75 80

gtt?ttc?gag?tcg?att?atc?tcc?acc?gat?cac?att?gat?ttc?cct?ggt?tgg 288

Val?Phe?Glu?Ser?Ile?Ile?Ser?Thr?Asp?His?Ile?Asp?Phe?Pro?Gly?Trp

85 90 95

ggc?gac?aat?gag?ggt?ttc?caa?gtc?tgg?aac?gat?aac?gcc?ttg?ttc?atg 336

Gly?Asp?Asn?Glu?Gly?Phe?Gln?Val?Trp?Asn?Asp?Asn?Ala?Leu?Phe?Met

100 105 110

aac?gat?cct?gat?ggc?atc?ggc?ggc?aag?acc?ggc?tac?acc?gac?gac?gcg 384

Asn?Asp?Pro?Asp?Gly?Ile?Gly?Gly?Lys?Thr?Gly?Tyr?Thr?Asp?Asp?Ala

115 120 125

aac?cac?acc?ttt?gtc?ggc?ggt?ctc?gat?cgg?ggt?ggt?cgc?cgc?ctc?gcc 432

Asn?His?Thr?Phe?Val?Gly?Gly?Leu?Asp?Arg?Gly?Gly?Arg?Arg?Leu?Ala

130 135 140

gcc?gta?ctc?ttg?gat?tcc?acc?gtc?agc?gac?att?cgt?ccg?tgg?gaa?caa 480

Ala?Val?Leu?Leu?Asp?Ser?Thr?Val?Ser?Asp?Ile?Arg?Pro?Trp?Glu?Gln

145 150 155 160

gca?cga?ttg?ctt?atc?gac?gcc?tcc?ctc?ccc?atc?acg?ccg?ggg?tcc?ggc 528

Ala?Arg?Leu?Leu?Ile?Asp?Ala?Ser?Leu?Pro?Ile?Thr?Pro?Gly?Ser?Gly

165 170 175

gtg?ggc?cag?ctg?ggc?tcc?ggc?agc?gcg?aac?gat?gtg?gca?ccg?gcg?acc 576

Val?Gly?Gln?Leu?Gly?Ser?Gly?Ser?Ala?Asn?Asp?Val?Ala?Pro?Ala?Thr

180 185 190

cca?gaa?tta?cca?gaa?ccc?acc?gac?aac?ctg?act?tca?ggt?gag?ggt?ggg 624

Pro?Glu?Leu?Pro?Glu?Pro?Thr?Asp?Asn?Leu?Thr?Ser?Gly?Glu?Gly?Gly

195 200 205

tcg?cag?aac?acg?ctg?ctt?aag?ctc?gtg?gtg?ccc?atc?gga?atc?atc?gtg 672

Ser?Gln?Asn?Thr?Leu?Leu?Lys?Leu?Val?Val?Pro?Ile?Gly?Ile?Ile?Val

210 215 220

ctg?ttg?cta?atc?gcc?gca?cta?gcg?tgg?aca?ttc?aga?tct?ccc?aag?aaa 720

Leu?Leu?Leu?Ile?Ala?Ala?Leu?Ala?Trp?Thr?Phe?Arg?Ser?Pro?Lys?Lys

225 230 235 240

aag?aac?taggtgttct?tcttcacgac?ctc 749

Lys?Asn

<210>92

<211>242

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>92

Gln?Tyr?Thr?Val?Asp?Gln?Leu?Leu?His?Gly?Leu?Leu?Leu?Ala?Ser?Gly

1 5 10 15

Asn?Asp?Ala?Ala?Tyr?Leu?Leu?Ala?Gln?Glu?Leu?Gly?Gly?Asp?Gln?Ala

20 25 30

Thr?Leu?Glu?Lys?Val?Asn?Ala?Leu?Ala?Lys?Glu?Leu?Gly?Thr?Gln?Asp

35 40 45

Thr?Phe?Val?Ala?Thr?Tyr?Ser?Gly?Leu?Asp?Ala?Pro?Gly?Met?Ser?Thr

50 55 60

Ser?Ala?Tyr?Asp?Met?Ser?Leu?Ile?Tyr?Gln?His?Ala?Trp?Gln?Asn?Pro

65 70 75 80

Val?Phe?Glu?Ser?Ile?Ile?Ser?Thr?Asp?His?Ile?Asp?Phe?Pro?Gly?Trp

85 90 95

Gly?Asp?Asn?Glu?Gly?Phe?Gln?Val?Trp?Asn?Asp?Asn?Ala?Leu?Phe?Met

100 105 110

Asn?Asp?Pro?Asp?Gly?Ile?Gly?Gly?Lys?Thr?Gly?Tyr?Thr?Asp?Asp?Ala

115 120 125

Asn?His?Thr?Phe?Val?Gly?Gly?Leu?Asp?Arg?Gly?Gly?Arg?Arg?Leu?Ala

130 135 140

Ala?Val?Leu?Leu?Asp?Ser?Thr?Val?Ser?Asp?Ile?Arg?Pro?Trp?Glu?Gln

145 150 155 160

Ala?Arg?Leu?Leu?Ile?Asp?Ala?Ser?Leu?Pro?Ile?Thr?Pro?Gly?Ser?Gly

165 170 175

Val?Gly?Gln?Leu?Gly?Ser?Gly?Ser?Ala?Asn?Asp?Val?Ala?Pro?Ala?Thr

180 185 190

Pro?Glu?Leu?Pro?Glu?Pro?Thr?Asp?Asn?Leu?Thr?Ser?Gly?Glu?Gly?Gly

195 200 205

Ser?Gln?Asn?Thr?Leu?Leu?Lys?Leu?Val?Val?Pro?Ile?Gly?Ile?Ile?Val

210 215 220

Leu?Leu?Leu?Ile?Ala?Ala?Leu?Ala?Trp?Thr?Phe?Arg?Ser?Pro?Lys?Lys

225 230 235 240

Lys?Asn

<210>93

<211>1212

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1189)

<223>RXA00137

<400>93

tttacagagt?gcttatgagg?caatcagcca?ctaagtgttg?agtaatctac?tagtttggac?60

tagaagttac?ccactttcag?tgaattttta?aggagagaac?atg?gct?ttg?gct?gat 115

Met?Ala?Leu?Ala?Asp

1 5

acc?cga?ttt?gcc?act?cgt?cgt?cgc?gca?ctt?gcc?gca?aaa?ctg?gca?gct 163

Thr?Arg?Phe?Ala?Thr?Arg?Arg?Arg?Ala?Leu?Ala?Ala?Lys?Leu?Ala?Ala

10 15 20

caa?cgg?atc?gac?tca?att?ttg?gtg?aca?agc?ccg?atc?cat?gtt?cgc?tat 211

Gln?Arg?Ile?Asp?Ser?Ile?Leu?Val?Thr?Ser?Pro?Ile?His?Val?Arg?Tyr

25 30 35

ctc?agc?gga?ttc?acc?ggc?tcc?aac?ggc?gca?ctg?atc?gtg?aac?aaa?gat 259

Leu?Ser?Gly?Phe?Thr?Gly?Ser?Asn?Gly?Ala?Leu?Ile?Val?Asn?Lys?Asp

40 45 50

ctc?tcc?gcg?cag?atc?tgc?acc?gac?ggt?cgc?tac?acc?acc?cag?atc?gca 307

Leu?Ser?Ala?Gln?Ile?Cys?Thr?Asp?Gly?Arg?Tyr?Thr?Thr?Gln?Ile?Ala

55 60 65

gaa?gaa?gtc?ccg?gac?atc?gag?gcg?ctg?att?gag?cgt?gcc?tcg?gca?acg 355

Glu?Glu?Val?Pro?Asp?Ile?Glu?Ala?Leu?Ile?Glu?Arg?Ala?Ser?Ala?Thr

70 75 80 85

acg?ctg?cta?gcg?cag?gtc?gaa?ggg?ccg?cgt?cgt?ata?gca?atc?gaa?gcc 403

Thr?Leu?Leu?Ala?Gln?Val?Glu?Gly?Pro?Arg?Arg?Ile?Ala?Ile?Glu?Ala

90 95 100

gca?caa?acc?acc?ctg?gac?cag?cta?gac?agc?ctg?cgt?gaa?gca?acc?cag 451

Ala?Gln?Thr?Thr?Leu?Asp?Gln?Leu?Asp?Ser?Leu?Arg?Glu?Ala?Thr?Gln

105 110 115

gaa?gac?gtc?gag?ctg?atc?ccc?gtg?tca?ggt?gtt?gtg?gaa?tcc?att?cgc 499

Glu?Asp?Val?Glu?Leu?Ile?Pro?Val?Ser?Gly?Val?Val?Glu?Ser?Ile?Arg

120 125 130

ctg?acc?aaa?gac?agc?ttc?gaa?ctc?gac?cgc?ctc?cgc?gat?gtc?gca?gcg 547

Leu?Thr?Lys?Asp?Ser?Phe?Glu?Leu?Asp?Arg?Leu?Arg?Asp?Val?Ala?Ala

135 140 145

ctg?gct?tcc?caa?gca?ttc?gaa?gat?tta?ctc?gca?gca?gga?gaa?ctc?gcc 595

Leu?Ala?Ser?Gln?Ala?Phe?Glu?Asp?Leu?Leu?Ala?Ala?Gly?Glu?Leu?Ala

150 155 160 165

gaa?ggc?cga?tca?gag?cgc?caa?gtc?gcc?gcc?gat?ctg?gaa?tac?cgc?atg 643

Glu?Gly?Arg?Ser?Glu?Arg?Gln?Val?Ala?Ala?Asp?Leu?Glu?Tyr?Arg?Met

170 175 180

cgc?ctg?ttg?gga?gca?gaa?cgc?ccc?agc?ttc?gac?acc?atc?gtg?gcc?tct 691

Arg?Leu?Leu?Gly?Ala?Glu?Arg?Pro?Ser?Phe?Asp?Thr?Ile?Val?Ala?Ser

185 190 195

gga?cct?aac?tcc?gcg?aaa?cca?cac?cac?ggc?gca?ggc?gac?cgc?atc?ctc 739

Gly?Pro?Asn?Ser?Ala?Lys?Pro?His?His?Gly?Ala?Gly?Asp?Arg?Ile?Leu

200 205 210

cag?cgc?ggc?gat?cta?gtc?acc?atc?gat?ttc?ggc?gca?cac?gca?cgc?gga 787

Gln?Arg?Gly?Asp?Leu?Val?Thr?Ile?Asp?Phe?Gly?Ala?His?Ala?Arg?Gly

215 220 225

ttc?aac?tcc?gat?atg?acc?cgc?acc?ctc?gtt?atg?ggc?gaa?gca?ggg?gag 835

Phe?Asn?Ser?Asp?Met?Thr?Arg?Thr?Leu?Val?Met?Gly?Glu?Ala?Gly?Glu

230 235 240 245

ttc?gaa?gca?gaa?atc?tac?gac?atc?gtc?ctg?cgc?tcc?caa?ctc?gct?ggt 883

Phe?Glu?Ala?Glu?Ile?Tyr?Asp?Ile?Val?Leu?Arg?Ser?Gln?Leu?Ala?Gly

250 255 260

gtt?gaa?gca?gcc?tac?tca?ggc?gcc?aac?ctc?ttc?gac?atc?gac?gca?gca 931

Val?Glu?Ala?Ala?Tyr?Ser?Gly?Ala?Asn?Leu?Phe?Asp?Ile?Asp?Ala?Ala

265 270 275

tgc?cgc?aaa?atc?atc?gaa?gac?gca?ggc?tac?ggc?gaa?tac?ttc?gtg?cac 979

Cys?Arg?Lys?Ile?Ile?Glu?Asp?Ala?Gly?Tyr?Gly?Glu?Tyr?Phe?Val?His

280 285 290

tcc?acc?ggc?cac?ggc?atc?gga?ctt?gaa?gtc?cac?gaa?gcc?cca?agc?gca 1027

Ser?Thr?Gly?His?Gly?Ile?Gly?Leu?Glu?Val?His?Glu?Ala?Pro?Ser?Ala

295 300 305

tcc?aaa?acc?tca?caa?gga?gtc?cta?gaa?acc?ggc?tcc?aca?ctg?acc?atc 1075

Ser?Lys?Thr?Ser?Gln?Gly?Val?Leu?Glu?Thr?Gly?Ser?Thr?Leu?Thr?Ile

310 315 320 325

gaa?ccc?gga?att?tac?gtc?ccc?gga?aag?ggc?ggc?gta?cgc?atc?gaa?gac 1123

Glu?Pro?Gly?Ile?Tyr?Val?Pro?Gly?Lys?Gly?Gly?Val?Arg?Ile?Glu?Asp

330 335 340

acc?ctg?att?att?acc?tca?gga?gca?ccg?gaa?atc?atc?acc?aag?gtg?agt 1171

Thr?Leu?Ile?Ile?Thr?Ser?Gly?Ala?Pro?Glu?Ile?Ile?Thr?Lys?Val?Ser

345 350 355

aag?gac?ctc?atc?gtg?gtg?taatctaggt?gagctaatcg?gtc 1212

Lys?Asp?Leu?Ile?Val?Val

360

<210>94

<211>363

<2l2>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>94

Met?Ala?Leu?Ala?Asp?Thr?Arg?Phe?Ala?Thr?Arg?Arg?Arg?Ala?Leu?Ala

1 5 10 15

Ala?Lys?Leu?Ala?Ala?Gln?Arg?Ile?Asp?Ser?Ile?Leu?Val?Thr?Ser?Pro

20 25 30

Ile?His?Val?Arg?Tyr?Leu?Ser?Gly?Phe?Thr?Gly?Ser?Asn?Gly?Ala?Leu

35 40 45

Ile?Val?Asn?Lys?Asp?Leu?Ser?Ala?Gln?Ile?Cys?Thr?Asp?Gly?Arg?Tyr

50 55 60

Thr?Thr?Gln?Ile?Ala?Glu?Glu?Val?Pro?Asp?Ile?Glu?Ala?Leu?Ile?Glu

65 70 75 80

Arg?Ala?Ser?Ala?Thr?Thr?Leu?Leu?Ala?Gln?Val?Glu?Gly?Pro?Arg?Arg

85 90 95

Ile?Ala?Ile?Glu?Ala?Ala?Gln?Thr?Thr?Leu?Asp?Gln?Leu?Asp?Ser?Leu

100 105 110

Arg?Glu?Ala?Thr?Gln?Glu?Asp?Val?Glu?Leu?Ile?Pro?Val?Ser?Gly?Val

115 120 125

Val?Glu?Ser?Ile?Arg?Leu?Thr?Lys?Asp?Ser?Phe?Glu?Leu?Asp?Arg?Leu

130 135 140

Arg?Asp?Val?Ala?Ala?Leu?Ala?Ser?Gln?Ala?Phe?Glu?Asp?Leu?Leu?Ala

145 150 155 160

Ala?Gly?Glu?Leu?Ala?Glu?Gly?Arg?Ser?Glu?Arg?Gln?Val?Ala?Ala?Asp

165 170 175

Leu?Glu?Tyr?Arg?Met?Arg?Leu?Leu?Gly?Ala?Glu?Arg?Pro?Ser?Phe?Asp

180 185 190

Thr?Ile?Val?Ala?Ser?Gly?Pro?Ash?Ser?Ala?Lys?Pro?His?His?Gly?Ala

195 200 205

Gly?Asp?Arg?Ile?Leu?Gln?Arg?Gly?Asp?Leu?Val?Thr?Ile?Asp?Phe?Gly

210 215 220

Ala?His?Ala?Arg?Gly?Phe?Asn?Ser?Asp?Met?Thr?Arg?Thr?Leu?Val?Met

225 230 235 240

Gly?Glu?Ala?Gly?Glu?Phe?Glu?Ala?Glu?Ile?Tyr?Asp?Ile?Val?Leu?Arg

245 250 255

Ser?Gln?Leu?Ala?Gly?Val?Glu?Ala?Ala?Tyr?Ser?Gly?Ala?Asn?Leu?Phe

260 265 270

Asp?Ile?Asp?Ala?Ala?Cys?Arg?Lys?Ile?Ile?Glu?Asp?Ala?Gly?Tyr?Gly

275 280 285

Glu?Tyr?Phe?Val?His?Ser?Thr?Gly?His?Gly?Ile?Gly?Leu?Glu?Val?His

290 295 300

Glu?Ala?Pro?Ser?Ala?Ser?Lys?Thr?Ser?Gln?Gly?Val?Leu?Glu?Thr?Gly

305 310 315 320

Ser?Thr?Leu?Thr?Ile?Glu?Pro?Gly?Ile?Tyr?Val?Pro?Gly?Lys?Gly?Gly

325 330 335

Val?Arg?Ile?Glu?Asp?Thr?Leu?Ile?Ile?Thr?Ser?Gly?Ala?Pro?Glu?Ile

340 345 350

Ile?Thr?Lys?Val?Ser?Lys?Asp?Leu?Ile?Val?Val

355 360

<210>95

<211>1404

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1381)

<223>RXN00499

<400>95

tgccaacagg?ggatatgcca?ctgtgtaccc?cacggcgatg?atcggtaaaa?tcctcggcgc?60

gcagatattg?ttcttgctgc?tctaaggtga?tttttgggca?gtg?gtg?ggg?gtg?gtg 115

Val?Val?Gly?Val?Val

1 5

tcc?acc?cct?gcg?cgt?aac?ctg?gga?agc?atg?act?aaa?aca?ctt?ggt?tcc 163

Ser?Thr?Pro?Ala?Arg?Asn?Leu?Gly?Ser?Met?Thr?Lys?Thr?Leu?Gly?Ser

10 15 20

ctt?cag?ctg?gaa?gaa?atc?acg?ctg?acc?ctc?cct?ctg?act?gaa?gat?gtg 211

Leu?Gln?Leu?Glu?Glu?Ile?Thr?Leu?Thr?Leu?Pro?Leu?Thr?Glu?Asp?Val

25 30 35

gcc?gat?gaa?cgc?acc?att?gat?gtg?ttc?gca?cgc?att?gcc?aca?cgc?gtc 259

Ala?Asp?Glu?Arg?Thr?Ile?Asp?Val?Phe?Ala?Arg?Ile?Ala?Thr?Arg?Val

40 45 50

ggt?ggg?gaa?gac?ctt?cca?tat?tta?gta?ttc?ctg?cag?ggt?ggg?cct?ggc 307

Gly?Gly?Glu?Asp?Leu?Pro?Tyr?Leu?Val?Phe?Leu?Gln?Gly?Gly?Pro?Gly

55 60 65

aat?gaa?gct?cca?cgt?cca?agc?ctt?aat?ccc?ctc?aac?ccc?aat?tgg?ttg 355

Asn?Glu?Ala?Pro?Arg?Pro?Ser?Leu?Asn?Pro?Leu?Asn?Pro?Asn?Trp?Leu

70 75 80 85

ggc?gtg?gcc?ttg?gag?gaa?tac?cgc?gtg?gtc?atg?ttg?gat?caa?cgt?ggc 403

Gly?Val?Ala?Leu?Glu?Glu?Tyr?Arg?Val?Val?Met?Leu?Asp?Gln?Arg?Gly

90 95 100

acc?ggc?cgt?tcc?acc?cca?gtg?ggt?aat?gat?att?ttg?gaa?aaa?ccc?aca 451

Thr?Gly?Arg?Ser?Thr?Pro?Val?Gly?Asn?Asp?Ile?Leu?Glu?Lys?Pro?Thr

105 110 115

gca?gaa?gta?gtg?gag?tac?tta?tcc?cac?ctg?cgc?gca?gat?ggc?att?gtg 499

Ala?Glu?Val?Val?Glu?Tyr?Leu?Ser?His?Leu?Arg?Ala?Asp?Gly?Ile?Val

120 125 130

cga?gat?gct?gaa?gcc?ctg?cgt?aag?cat?ttg?ggt?gtg?aat?cag?tgg?aac 547

Arg?Asp?Ala?Glu?Ala?Leu?Arg?Lys?His?Leu?Gly?Val?Asn?Gln?Trp?Asn

135 140 145

ctt?tta?ggc?cag?tcc?ttc?gga?ggt?ttc?acc?acc?ctg?cat?tac?ttg?tcc 595

Leu?Leu?Gly?Gln?Ser?Phe?Gly?Gly?Phe?Thr?Thr?Leu?His?Tyr?Leu?Ser

150 155 160 165

cgg?cac?gcc?gat?tcc?ttg?gac?aac?gtg?ttt?att?acc?ggc?ggt?ctc?agc 643

Arg?His?Ala?Asp?Ser?Leu?Asp?Asn?Val?Phe?Ile?Thr?Gly?Gly?Leu?Ser

170 175 180

gct?att?gat?cgc?cca?gca?gaa?gac?gtg?tat?gcc?aac?tgt?tac?aac?cgc 691

Ala?Ile?Asp?Arg?Pro?Ala?Glu?Asp?Val?Tyr?Ala?Asn?Cys?Tyr?Asn?Arg

185 190 195

atg?cgc?cga?aac?tct?gag?gaa?ttc?tac?cgt?cgc?ttc?ccg?caa?tta?cgg 739

Met?Arg?Arg?Asn?Ser?Glu?Glu?Phe?Tyr?Arg?Arg?Phe?Pro?Gln?Leu?Arg

200 205 210

gaa?act?ttc?cga?ggg?ttg?gtt?aat?cgt?gct?cgc?gcc?ggg?gag?att?gtg 787

Glu?Thr?Phe?Arg?Gly?Leu?Val?Asn?Arg?Ala?Arg?Ala?Gly?Glu?Ile?Val

215 220 225

ctt?ccc?acc?ggc?gaa?gtt?gtg?tca?gaa?acc?agg?ctg?cga?tcc?ctt?ggt 835

Leu?Pro?Thr?Gly?Glu?Val?Val?Ser?Glu?Thr?Arg?Leu?Arg?Ser?Leu?Gly

230 235 240 245

cac?ttg?ttg?ggt?agc?aat?gac?ggc?tgg?ttt?gat?ctg?tac?aac?ctg?ctg 883

His?Leu?Leu?Gly?Ser?Asn?Asp?Gly?Trp?Phe?Asp?Leu?Tyr?Asn?Leu?Leu

250 255 260

gaa?tta?gat?ccc?acc?tcc?aac?gct?ttt?gtc?cat?gac?ctg?gca?gga?ctt 931

Glu?Leu?Asp?Pro?Thr?Ser?Asn?Ala?Phe?Val?His?Asp?Leu?Ala?Gly?Leu

265 270 275

ttg?cct?ttc?ggc?aac?cgc?aac?cca?att?tat?tac?gtg?ctc?cat?gag?tcc 979

Leu?Pro?Phe?Gly?Asn?Arg?Asn?Pro?Ile?Tyr?Tyr?Val?Leu?His?Glu?Ser

280 285 290

tct?tac?gcc?gac?ggt?gtg?gtg?aca?aat?tgg?gca?gca?gag?cgt?gtg?ctt 1027

Ser?Tyr?Ala?Asp?Gly?Val?Val?Thr?Asn?Trp?Ala?Ala?Glu?Arg?Val?Leu

295 300 305

cca?gag?gat?ttc?cgc?gag?gat?cca?aca?ctg?ctc?acc?ggt?gag?cac?gtg 1075

Pro?Glu?Asp?Phe?Arg?Glu?Asp?Pro?Thr?Leu?Leu?Thr?Gly?Glu?His?Val

310 315 320 325

ttc?cag?gag?tgg?aca?gac?acc?gtg?ccg?tcg?ctc?aag?ccg?tgg?aag?gac 1123

Phe?Gln?Glu?Trp?Thr?Asp?Thr?Val?Pro?Ser?Leu?Lys?Pro?Trp?Lys?Asp

330 335 340

gtt?gcc?ctg?gca?ttg?gct?cag?cag?gaa?tgg?ccc?aag?ctt?tat?gat?gcg 1171

Val?Ala?Leu?Ala?Leu?Ala?Gln?Gln?Glu?Trp?Pro?Lys?Leu?Tyr?Asp?Ala

345 350 355

aag?gca?ttg?gaa?aac?tca?cag?gcc?aag?ggc?gct?gca?gca?gtg?tat?gcc 1219

Lys?Ala?Leu?Glu?Asn?Ser?Gln?Ala?Lys?Gly?Ala?Ala?Ala?Val?Tyr?Ala

360 365 370

aat?gac?gtt?ttc?gtc?cca?gtg?gat?tac?tct?ctg?gaa?acc?gca?caa?cac 1267

Asn?Asp?Val?Phe?Val?Pro?Val?Asp?Tyr?Ser?Leu?Glu?Thr?Ala?Gln?His

375 380 385

ctg?ccc?ggt?gtg?cag?ctg?ttt?atc?acc?agc?cag?cat?gaa?cac?aat?gga 1315

Leu?Pro?Gly?Val?Gln?Leu?Phe?Ile?Thr?Ser?Gln?His?Glu?His?Asn?Gly

390 395 400 405

ctt?cgt?gcc?agc?tca?ggc?gca?gta?ctg?aag?cac?ctt?ttc?gat?ctg?gcc 1363

Leu?Arg?Ala?Ser?Ser?Gly?Ala?Val?Leu?Lys?His?Leu?Phe?Asp?Leu?Ala

410 415 420

cac?ggc?cga?gag?gta?cgc?tgattcctcg?tgttagtact?agc 1404

His?Gly?Arg?Glu?Val?Arg

425

<210>96

<211>427

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>96

Val?Val?Gly?Val?Val?Ser?Thr?Pro?Ala?Arg?Asn?Leu?Gly?Ser?Met?Thr

1 5 10 15

Lys?Thr?Leu?Gly?Ser?Leu?Gln?Leu?Glu?Glu?Ile?Thr?Leu?Thr?Leu?Pro

20 25 30

Leu?Thr?Glu?Asp?Val?Ala?Asp?Glu?Arg?Thr?Ile?Asp?Val?Phe?Ala?Arg

35 40 45

Ile?Ala?Thr?Arg?Val?Gly?Gly?Glu?Asp?Leu?Pro?Tyr?Leu?Val?Phe?Leu

50 55 60

Gln?Gly?Gly?Pro?Gly?Asn?Glu?Ala?Pro?Arg?Pro?Ser?Leu?Asn?Pro?Leu

65 70 75 80

Asn?Pro?Asn?Trp?Leu?Gly?Val?Ala?Leu?Glu?Glu?Tyr?Arg?Val?Val?Met

85 90 95

Leu?Asp?Gln?Arg?Gly?Thr?Gly?Arg?Ser?Thr?Pro?Val?Gly?Asn?Asp?Ile

100 105 110

Leu?Glu?Lys?Pro?Thr?Ala?Glu?Val?Val?Glu?Tyr?Leu?Ser?His?Leu?Arg

115 120 125

Ala?Asp?Gly?Ile?Val?Arg?Asp?Ala?Glu?Ala?Leu?Arg?Lys?His?Leu?Gly

130 135 140

Val?Asn?Gln?Trp?Asn?Leu?Leu?Gly?Gln?Ser?Phe?Gly?Gly?Phe?Thr?Thr

145 150 155 160

Leu?His?Tyr?Leu?Ser?Arg?His?Ala?Asp?Ser?Leu?Asp?Asn?Val?Phe?Ile

165 170 175

Thr?Gly?Gly?Leu?Ser?Ala?Ile?Asp?Arg?Pro?Ala?Glu?Asp?Val?Tyr?Ala

180 185 190

Asn?Cys?Tyr?Asn?Arg?Met?Arg?Arg?Asn?Ser?Glu?Glu?Phe?Tyr?Arg?Arg

195 200 205

Phe?Pro?Gln?Leu?Arg?Glu?Thr?Phe?Arg?Gly?Leu?Val?Asn?Arg?Ala?Arg

210 215 220

Ala?Gly?Glu?Ile?Val?Leu?Pro?Thr?Gly?Glu?Val?Val?Ser?Glu?Thr?Arg

225 230 235 240

Leu?Arg?Ser?Leu?Gly?His?Leu?Leu?Gly?Ser?Asn?Asp?Gly?Trp?Phe?Asp

245 250 255

Leu?Tyr?Asn?Leu?Leu?Glu?Leu?Asp?Pro?Thr?Ser?Asn?Ala?Phe?Val?His

260 265 270

Asp?Leu?Ala?Gly?Leu?Leu?Pro?Phe?Gly?Asn?Arg?Asn?Pro?Ile?Tyr?Tyr

275 280 285

Val?Leu?His?Glu?Ser?Ser?Tyr?Ala?Asp?Gly?Val?Val?Thr?Asn?Trp?Ala

290 295 300

Ala?Glu?Arg?Val?Leu?Pro?Glu?Asp?Phe?Arg?Glu?Asp?Pro?Thr?Leu?Leu

305 310 315 320

Thr?Gly?Glu?His?Val?Phe?Gln?Glu?Trp?Thr?Asp?Thr?Val?Pro?Ser?Leu

325 330 335

Lys?Pro?Trp?Lys?Asp?Val?Ala?Leu?Ala?Leu?Ala?Gln?Gln?Glu?Trp?Pro

340 345 350

Lys?Leu?Tyr?Asp?Ala?Lys?Ala?Leu?Glu?Asn?Ser?Gln?Ala?Lys?Gly?Ala

355 360 365

Ala?Ala?Val?Tyr?Ala?Asn?Asp?Val?Phe?Val?Pro?Val?Asp?Tyr?Ser?Leu

370 375 380

Glu?Thr?Ala?Gln?His?Leu?Pro?Gly?Val?Gln?Leu?Phe?Ile?Thr?Ser?Gln

385 390 395 400

His?Glu?His?Asn?Gly?Leu?Arg?Ala?Ser?Ser?Gly?Ala?Val?Leu?Lys?His

405 410 415

Leu?Phe?Asp?Leu?Ala?His?Gly?Arg?Glu?Val?Arg

420 425

<210>97

<211>980

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(957)

<223>FRXA00499

<400>97

ggt?aat?gat?att?ttg?gaa?aaa?ccc?aca?gca?gaa?gta?gtg?gag?tac?tta 48

Gly?Asn?Asp?Ile?Leu?Glu?Lys?Pro?Thr?Ala?Glu?Val?Val?Glu?Tyr?Leu

1 5 10 15

tcc?cac?ctg?cgc?gca?gat?ggc?att?gtg?cga?gat?gct?gaa?gcc?ctg?cgt 96

Ser?His?Leu?Arg?Ala?Asp?Gly?Ile?Val?Arg?Asp?Ala?Glu?Ala?Leu?Arg

20 25 30

aag?cat?ttg?ggt?gtg?aat?cag?tgg?aac?ctt?tta?ggc?cag?tcc?ttc?gga 144

Lys?His?Leu?Gly?Val?Asn?Gln?Trp?Asn?Leu?Leu?Gly?Gln?Ser?Phe?Gly

35 40 45

ggt?ttc?acc?acc?ctg?cat?tac?ttg?tcc?cgg?cac?gcc?gat?tcc?ttg?gac 192

Gly?Phe?Thr?Thr?Leu?His?Tyr?Leu?Ser?Arg?His?Ala?Asp?Ser?Leu?Asp

50 55 60

aac?gtg?ttt?att?acc?ggc?ggt?ctc?agc?gct?att?gat?cgc?cca?gca?gaa 240

Asn?Val?Phe?Ile?Thr?Gly?Gly?Leu?Ser?Ala?Ile?Asp?Arg?Pro?Ala?Glu

65 70 75 80

gac?gtg?tat?gcc?aac?tgt?tac?aac?cgc?atg?cgc?cga?aac?tct?gag?gaa 288

Asp?Val?Tyr?Ala?Asn?Cys?Tyr?Asn?Arg?Met?Arg?Arg?Asn?Ser?Glu?Glu

85 90 95

ttc?tac?cgt?cgc?ttc?ccg?caa?tta?cgg?gaa?act?ttc?cga?ggg?ttg?gtt 336

Phe?Tyr?Arg?Arg?Phe?Pro?Gln?Leu?Arg?Glu?Thr?Phe?Arg?Gly?Leu?Val

100 105 110

aat?cgt?gct?cgc?gcc?ggg?gag?att?gtg?ctt?ccc?acc?ggc?gaa?gtt?gtg 384

Asn?Arg?Ala?Arg?Ala?Gly?Glu?Ile?Val?Leu?Pro?Thr?Gly?Glu?Val?Val

115 120 125

tca?gaa?acc?agg?ctg?cga?tcc?ctt?ggt?cac?ttg?ttg?ggt?agc?aat?gac 432

Ser?Glu?Thr?Arg?Leu?Arg?Ser?Leu?Gly?His?Leu?Leu?Gly?Ser?Asn?Asp

130 135 140

ggc?tgg?ttt?gat?ctg?tac?aac?ctg?ctg?gaa?tta?gat?ccc?acc?tcc?aac 480

Gly?Trp?Phe?Asp?Leu?Tyr?Asn?Leu?Leu?Glu?Leu?Asp?Pro?Thr?Ser?Asn

145 150 155 160

gct?ttt?gtc?cat?gac?ctg?gca?gga?ctt?ttg?cct?ttc?ggc?aac?cgc?aac 528

Ala?Phe?Val?His?Asp?Leu?Ala?Gly?Leu?Leu?Pro?Phe?Gly?Asn?Arg?Asn

165 170 175

cca?att?tat?tac?gtg?ctc?cat?gag?tcc?tct?tac?gcc?gac?ggt?gtg?gtg 576

Pro?Ile?Tyr?Tyr?Val?Leu?His?Glu?Ser?Ser?Tyr?Ala?Asp?Gly?Val?Val

180 185 190

aca?aat?tgg?gca?gca?gag?cgt?gtg?ctt?cca?gag?gat?ttc?cgc?gag?gat 624

Thr?Asn?Trp?Ala?Ala?Glu?Arg?Val?Leu?Pro?Glu?Asp?Phe?Arg?Glu?Asp

195 200 205

cca?aca?ctg?ctc?acc?ggt?gag?cac?gtg?ttc?cag?gag?tgg?aca?gac?acc 672

Pro?Thr?Leu?Leu?Thr?Gly?Glu?His?Val?Phe?Gln?Glu?Trp?Thr?Asp?Thr

210 215 220

gtg?ccg?tcg?ctc?aag?ccg?tgg?aag?gac?gtt?gcc?ctg?gca?ttg?gct?cag 720

Val?Pro?Ser?Leu?Lys?Pro?Trp?Lys?Asp?Val?Ala?Leu?Ala?Leu?Ala?Gln

225 230 235 240

cag?gaa?tgg?ccc?aag?ctt?tat?gat?gcg?aag?gca?ttg?gaa?aac?tca?cag 768

Gln?Glu?Trp?Pro?Lys?Leu?Tyr?Asp?Ala?Lys?Ala?Leu?Glu?Asn?Ser?Gln

245 250 255

gcc?aag?ggc?gct?gca?gca?gtg?tat?gcc?aat?gac?gtt?ttc?gtc?cca?gtg 816

Ala?Lys?Gly?Ala?Ala?Ala?Val?Tyr?Ala?Asn?Asp?Val?Phe?Val?Pro?Val

260 265 270

gat?tac?tct?ctg?gaa?acc?gca?caa?cac?ctg?ccc?ggt?gtg?cag?ctg?ttt 864

Asp?Tyr?Ser?Leu?Glu?Thr?Ala?Gln?His?Leu?Pro?Gly?Val?Gln?Leu?Phe

275 280 285

atc?acc?agc?cag?cat?gaa?cac?aat?gga?ctt?cgt?gcc?agc?tca?ggc?gca 912

lle?Thr?Ser?Gln?His?Glu?His?Asn?Gly?Leu?Arg?Ala?Ser?Ser?Gly?Ala

290 295 300

gta?ctg?aag?cac?ctt?ttc?gat?ctg?gcc?cac?ggc?cga?gag?gta?cgc 957

Val?Leu?Lys?His?Leu?Phe?Asp?Leu?Ala?His?Gly?Arg?Glu?Val?Arg

305 310 315

tgattcctcg?tgttagtact?agc 980

<210>98

<211>319

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>98

Gly?Asn?Asp?Ile?Leu?Glu?Lys?Pro?Thr?Ala?Glu?Val?Val?Glu?Tyr?Leu

1 5 10 15

Ser?His?Leu?Arg?Ala?Asp?Gly?Ile?Val?Arg?Asp?Ala?Glu?Ala?Leu?Arg

20 25 30

Lys?His?Leu?Gly?Val?Asn?Gln?Trp?Asn?Leu?Leu?Gly?Gln?Ser?Phe?Gly

35 40 45

Gly?Phe?Thr?Thr?Leu?His?Tyr?Leu?Ser?Arg?His?Ala?Asp?Ser?Leu?Asp

50 55 60

Asn?Val?Phe?Ile?Thr?Gly?Gly?Leu?Ser?Ala?Ile?Asp?Arg?Pro?Ala?Glu

65 70 75 80

Asp?Val?Tyr?Ala?Asn?Cys?Tyr?Asn?Arg?Met?Arg?Arg?Asn?Ser?Glu?Glu

85 90 95

Phe?Tyr?Arg?Arg?Phe?Pro?Gln?Leu?Arg?Glu?Thr?Phe?Arg?Gly?Leu?Val

100 105 110

Asn?Arg?Ala?Arg?Ala?Gly?Glu?Ile?Val?Leu?Pro?Thr?Gly?Glu?Val?Val

115 120 125

Ser?Glu?Thr?Arg?Leu?Arg?Ser?Leu?Gly?His?Leu?Leu?Gly?Ser?Asn?Asp

130 135 140

Gly?Trp?Phe?Asp?Leu?Tyr?Asn?Leu?Leu?Glu?Leu?Asp?Pro?Thr?Ser?Asn

145 150 155 160

Ala?Phe?Val?His?Asp?Leu?Ala?Gly?Leu?Leu?Pro?Phe?Gly?Asn?Arg?Asn

165 170 175

Pro?Ile?Tyr?Tyr?Val?Leu?His?Glu?Ser?Ser?Tyr?Ala?Asp?Gly?Val?Val

180 185 190

Thr?Asn?Trp?Ala?Ala?Glu?Arg?Val?Leu?Pro?Glu?Asp?Phe?Arg?Glu?Asp

195 200 205

Pro?Thr?Leu?Leu?Thr?Gly?Glu?His?Val?Phe?Gln?Glu?Trp?Thr?Asp?Thr

210 215 220

Val?Pro?Ser?Leu?Lys?Pro?Trp?Lys?Asp?Val?Ala?Leu?Ala?Leu?Ala?Gln

225 230 235 240

Gln?Glu?Trp?Pro?Lys?Leu?Tyr?Asp?Ala?Lys?Ala?Leu?Glu?Asn?Ser?Gln

245 250 255

Ala?Lys?Gly?Ala?Ala?Ala?Val?Tyr?Ala?Asn?Asp?Val?Phe?Val?Pro?Val

260 265 270

Asp?Tyr?Ser?Leu?Glu?Thr?Ala?Gln?His?Leu?Pro?Gly?Val?Gln?Leu?Phe

275 280 285

Ile?Thr?Ser?Gln?His?Glu?His?Asn?Gly?Leu?Arg?Ala?Ser?Ser?Gly?Ala

290 295 300

Val?Leu?Lys?His?Leu?Phe?Asp?Leu?Ala?His?Gly?Arg?Glu?Val?Arg

305 310 315

<210>99

<211>1788

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1765)

<223>RXN00877

<400>99

aaataatggg?gctcgccggt?gatggttccc?gccgggcatt?caacggtgac?ggaagaggtg?60

gcagacatga?tgaaaactct?agcaactagt?atcggtcact?atg?act?gtt?gaa?cac 115

Met?Thr?Val?Glu?His

1 5

ctg?ctc?aag?ccc?agc?acc?ttg?ccc?tac?cag?ctg?ccc?gat?ttc?gca?gcg 163

Leu?Leu?Lys?Pro?Ser?Thr?Leu?Pro?Tyr?Gln?Leu?Pro?Asp?Phe?Ala?Ala

10 15 20

atc?aag?gtg?gct?gat?ttc?ccg?ccc?gcc?ttc?gaa?ctc?gca?tta?gct?gaa 211

Ile?Lys?Val?Ala?Asp?Phe?Pro?Pro?Ala?Phe?Glu?Leu?Ala?Leu?Ala?Glu

25 30 35

cac?gat?gct?gaa?att?aca?gcg?atc?gct?acc?aat?gag?gac?gct?cct?acc 259

His?Asp?Ala?Glu?Ile?Thr?Ala?Ile?Ala?Thr?Asn?Glu?Asp?Ala?Pro?Thr

40 45 50

tgg?gag?aac?acc?att?gag?gcc?ctg?gaa?cgc?gca?ggc?ctg?tcc?ctc?aac 307

Trp?Glu?Asn?Thr?Ile?Glu?Ala?Leu?Glu?Arg?Ala?Gly?Leu?Ser?Leu?Asn

55 60 65

cgc?gtc?gcc?gcc?gta?ttc?ttc?aac?ttg?cag?ggc?acc?gat?tcc?tcc?cct 355

Arg?Val?Ala?Ala?Val?Phe?Phe?Asn?Leu?Gln?Gly?Thr?Asp?Ser?Ser?Pro

70 75 80 85

gaa?atg?gat?gaa?atc?gca?gcc?act?atc?gcg?ccg?aaa?ctc?tcc?gcg?cat 403

Glu?Met?Asp?Glu?Ile?Ala?Ala?Thr?Ile?Ala?Pro?Lys?Leu?Ser?Ala?His

90 95 100

tcg?gat?gcg?att?ttc?cac?aat?gct?gcg?ctt?ttc?gcg?cgc?att?gag?gcc 451

Ser?Asp?Ala?Ile?Phe?His?Asn?Ala?Ala?Leu?Phe?Ala?Arg?Ile?Glu?Ala

105 110 115

gta?gaa?gca?ccg?gcc?gac?gag?gaa?tcg?caa?cgc?ctg?ttg?tcc?cac?acc 499

Val?Glu?Ala?Pro?Ala?Asp?Glu?Glu?Ser?Gln?Arg?Leu?Leu?Ser?His?Thr

120 125 130

aag?cgc?gct?ttt?cga?cgt?cgc?ggt?gca?gca?ctc?aac?gcc?gac?ggc?aag 547

Lys?Arg?Ala?Phe?Arg?Arg?Arg?Gly?Ala?Ala?Leu?Asn?Ala?Asp?Gly?Lys

135 140 145

gcc?cga?ctg?agc?acc?atc?aac?cag?cgc?cta?tcg?gca?ctg?tcc?gaa?cag 595

Ala?Arg?Leu?Ser?Thr?Ile?Asn?Gln?Arg?Leu?Ser?Ala?Leu?Ser?Glu?Gln

150 155 160 165

ttc?ggc?cgc?aac?ctg?ctt?cag?gac?acc?cgc?gat?ctg?gcg?gtc?aac?ttt 643

Phe?Gly?Arg?Asn?Leu?Leu?Gln?Asp?Thr?Arg?Asp?Leu?Ala?Val?Asn?Phe

170 175 180

gaa?gaa?tct?gaa?ctt?gcc?ggt?ttt?agc?gaa?gcc?cgc?ata?tcc?gcc?gcc 691

Glu?Glu?Ser?Glu?Leu?Ala?Gly?Phe?Ser?Glu?Ala?Arg?Ile?Ser?Ala?Ala

185 190 195

gct?gac?tac?gca?gca?gca?gtt?ggc?acc?gaa?ggc?tac?gtg?gtt?cca?ctg 739

Ala?Asp?Tyr?Ala?Ala?Ala?Val?Gly?Thr?Glu?Gly?Tyr?Val?Val?Pro?Leu

200 205 210

gaa?ctg?ccc?acc?gtg?cag?tca?gag?cag?gca?gta?tta?acc?gaa?tcc?gcc 787

Glu?Leu?Pro?Thr?Val?Gln?Ser?Glu?Gln?Ala?Val?Leu?Thr?Glu?Ser?Ala

215 220 225

tcg?cgt?gca?aag?ctt?tat?gaa?gcc?tcc?cag?aag?cgt?ggc?gcc?agc?ctg 835

Ser?Arg?Ala?Lys?Leu?Tyr?Glu?Ala?Ser?Gln?Lys?Arg?Gly?Ala?Ser?Leu

230 235 240 245

aac?aag?gac?gtg?ctg?ctc?gaa?acc?gtg?cgt?ctg?cgt?gct?gaa?cgc?gcc 883

Asn?Lys?Asp?Val?Leu?Leu?Glu?Thr?Val?Arg?Leu?Arg?Ala?Glu?Arg?Ala

250 255 260

aca?ctt?tta?ggc?tac?gac?acc?cac?gcc?gat?tac?gtc?atc?gaa?gaa?gaa 931

Thr?Leu?Leu?Gly?Tyr?Asp?Thr?His?Ala?Asp?Tyr?Val?Ile?Glu?Glu?Glu

265 270 275

acc?gcc?gat?gac?gtc?gca?gcc?gtg?cgc?gcc?ttg?ctt?tat?gat?ctc?gcc 979

Thr?Ala?Asp?Asp?Val?Ala?Ala?Val?Arg?Ala?Leu?Leu?Tyr?Asp?Leu?Ala

280 285 290

cca?gcc?gcc?tct?gcc?aat?gcg?aaa?gcc?gaa?tac?aaa?ctc?tcc?gca?gaa 1027

Pro?Ala?Ala?Ser?Ala?Asn?Ala?Lys?Ala?Glu?Tyr?Lys?Leu?Ser?Ala?Glu

295 300 305

gaa?gca?gaa?gaa?cac?ggc?caa?aaa?gtc?ggc?gca?gct?gac?tgg?agc?ttc 1075

Glu?Ala?Glu?Glu?His?Gly?Gln?Lys?Val?Gly?Ala?Ala?Asp?Trp?Ser?Phe

310 315 320 325

tgg?gaa?gcc?aaa?gtc?cgc?gcc?cgc?gac?tac?gcc?ctg?gac?gaa?acc?gaa 1123

Trp?Glu?Ala?Lys?Val?Arg?Ala?Arg?Asp?Tyr?Ala?Leu?Asp?Glu?Thr?Glu

330 335 340

ctg?cgc?aac?tac?ttc?cca?ttg?aac?caa?gta?ctc?cgt?gac?ggc?gtc?ttc 1171

Leu?Arg?Asn?Tyr?Phe?Pro?Leu?Asn?Gln?Val?Leu?Arg?Asp?Gly?Val?Phe

345 350 355

ttc?gct?gct?aac?cgc?ctc?tac?gga?atc?acc?gtg?gaa?cca?cgc?cct?gac 1219

Phe?Ala?Ala?Asn?Arg?Leu?Tyr?Gly?Ile?Thr?Val?Glu?Pro?Arg?Pro?Asp

360 365 370

ctg?cgc?ggt?tac?gcc?gag?ggc?gtg?gac?gtc?tgg?gaa?gtc?ctc?gat?tct 1267

Leu?Arg?Gly?Tyr?Ala?Glu?Gly?Val?Asp?Val?Trp?Glu?Val?Leu?Asp?Ser

375 380 385

gac?ggc?tcc?ggc?atc?ggc?ctg?atc?ctt?acc?gac?tac?tac?ggc?cga?cca 1315

Asp?Gly?Ser?Gly?Ile?Gly?Leu?Ile?Leu?Thr?Asp?Tyr?Tyr?Gly?Arg?Pro

390 395 400 405

tcc?aag?cgg?ggc?ggc?gct?tgg?atg?tcc?agc?ttt?gtc?gac?caa?tcc?gag 1363

Ser?Lys?Arg?Gly?Gly?Ala?Trp?Met?Ser?Ser?Phe?Val?Asp?Gln?Ser?Glu

410 415 420

ctg?cta?ggc?acc?aag?cca?gtc?gtg?gtc?aac?gtt?atg?ggt?att?acc?aaa 1411

Leu?Leu?Gly?Thr?Lys?Pro?Val?Val?Val?Asn?Val?Met?Gly?Ile?Thr?Lys

425 430 435

cca?acc?acc?ggc?gaa?gca?cta?ctc?agc?ctc?gat?gaa?gta?acc?acc?atc 1459

Pro?Thr?Thr?Gly?Glu?Ala?Leu?Leu?Ser?Leu?Asp?Glu?Val?Thr?Thr?Ile

440 445 450

ttc?cac?gaa?ttc?ggc?cac?ggc?ctg?cac?ggc?ttg?ctg?tcc?aag?gtg?cgc 1507

Phe?His?Glu?Phe?Gly?His?Gly?Leu?His?Gly?Leu?Leu?Ser?Lys?Val?Arg

455 460 465

tac?cca?agc?ttc?tcc?gga?acc?tcc?gtg?ccc?cgc?gac?tac?gta?gaa?ttc 1555

Tyr?Pro?Ser?Phe?Ser?Gly?Thr?Ser?Val?Pro?Arg?Asp?Tyr?Val?Glu?Phe

470 475 480 485

ccc?tcc?cag?atc?aac?gaa?aac?tgg?gca?ttc?gac?cct?gca?gta?gtc?cgc 1603

Pro?Ser?Gln?Ile?Asn?Glu?Asn?Trp?Ala?Phe?Asp?Pro?Ala?Val?Val?Arg

490 495 500

aac?tac?gcc?cgc?cac?gtg?gac?acc?ggc?gac?atc?att?cca?gac?tcc?ctg 1651

Asn?Tyr?Ala?Arg?His?Val?Asp?Thr?Gly?Asp?Ile?Ile?Pro?Asp?Ser?Leu

505 510 515

ctt?gag?gca?gtg?gaa?gca?tgt?ggc?att?tca?gac?aga?gtg?gtg?gaa?cat 1699

Leu?Glu?Ala?Val?Glu?Ala?Cys?Gly?Ile?Ser?Asp?Arg?Val?Val?Glu?His

520 525 530

gtg?agt?act?tgt?ccc?cat?cta?tta?tcg?acc?tgc?cct?gtc?tct?ccc?tgt 1747

Val?Ser?Thr?Cys?Pro?His?Leu?Leu?Ser?Thr?Cys?Pro?Val?Ser?Pro?Cys

535 540 545

cea?cag?cgg?atg?ccg?cac?tagtcaatga?cattgaccaa?tta 1788

Pro?Gln?Arg?Met?Pro?His

550 555

<210>100

<211>555

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>100

Met?Thr?Val?Glu?His?Leu?Leu?Lys?Pro?Ser?Thr?Leu?Pro?Tyr?Gln?Leu

1 5 10 15

Pro?Asp?Phe?Ala?Ala?Ile?Lys?Val?Ala?Asp?Phe?Pro?Pro?Ala?Phe?Glu

20 25 30

Leu?Ala?Leu?Ala?Glu?His?Asp?Ala?Glu?Ile?Thr?Ala?Ile?Ala?Thr?Asn

35 40 45

Glu?Asp?Ala?Pro?Thr?Trp?Glu?Asn?Thr?Ile?Glu?Ala?Leu?Glu?Arg?Ala

50 55 60

Gly?Leu?Ser?Leu?Asn?Arg?Val?Ala?Ala?Val?Phe?Phe?Asn?Leu?Gln?Gly

65 70 75 80

Thr?Asp?Ser?Ser?Pro?Glu?Met?Asp?Glu?Ile?Ala?Ala?Thr?Ile?Ala?Pro

85 90 95

Lys?Leu?Ser?Ala?His?Ser?Asp?Ala?Ile?Phe?His?Asn?Ala?Ala?Leu?Phe

100 105 110

Ala?Arg?Ile?Glu?Ala?Val?Glu?Ala?Pro?Ala?Asp?Glu?Glu?Ser?Gln?Arg

115 120 125

Leu?Leu?Ser?His?Thr?Lys?Arg?Ala?Phe?Arg?Arg?Arg?Gly?Ala?Ala?Leu

130 135 140

Asn?Ala?Asp?Gly?Lys?Ala?Arg?Leu?Ser?Thr?Ile?Asn?Gln?Arg?Leu?Ser

145 150 155 160

Ala?Leu?Ser?Glu?Gln?Phe?Gly?Arg?Asn?Leu?Leu?Gln?Asp?Thr?Arg?Asp

165 170 175

Leu?Ala?Val?Asn?Phe?Glu?Glu?Ser?Glu?Leu?Ala?Gly?Phe?Ser?Glu?Ala

180 185 190

Arg?Ile?Ser?Ala?Ala?Ala?Asp?Tyr?Ala?Ala?Ala?Val?Gly?Thr?Glu?Gly

195 200 205

Tyr?Val?Val?Pro?Leu?Glu?Leu?Pro?Thr?Val?Gln?Ser?Glu?Gln?Ala?Val

210 215 220

Leu?Thr?Glu?Ser?Ala?Ser?Arg?Ala?Lys?Leu?Tyr?Glu?Ala?Ser?Gln?Lys

225 230 235 240

Arg?Gly?Ala?Ser?Leu?Asn?Lys?Asp?Val?Leu?Leu?Glu?Thr?Val?Arg?Leu

245 250 255

Arg?Ala?Glu?Arg?Ala?Thr?Leu?Leu?Gly?Tyr?Asp?Thr?His?Ala?Asp?Tyr

260 265 270

Val?Ile?Glu?Glu?Glu?Thr?Ala?Asp?Asp?Val?Ala?Ala?Val?Arg?Ala?Leu

275 280 285

Leu?Tyr?Asp?Leu?Ala?Pro?Ala?Ala?Ser?Ala?Asn?Ala?Lys?Ala?Glu?Tyr

290 295 300

Lys?Leu?Ser?Ala?Glu?Glu?Ala?Glu?Glu?His?Gly?Gln?Lys?Val?Gly?Ala

305 310 315 320

Ala?Asp?Trp?Ser?Phe?Trp?Glu?Ala?Lys?Val?Arg?Ala?Arg?Asp?Tyr?Ala

325 330 335

Leu?Asp?Glu?Thr?Glu?Leu?Arg?Asn?Tyr?Phe?Pro?Leu?Asn?Gln?Val?Leu

340 345 350

Arg?Asp?Gly?Val?Phe?Phe?Ala?Ala?Asn?Arg?Leu?Tyr?Gly?Ile?Thr?Val

355 360 365

Glu?Pro?Arg?Pro?Asp?Leu?Arg?Gly?Tyr?Ala?Glu?Gly?Val?Asp?Val?Trp

370 375 380

Glu?Val?Leu?Asp?Ser?Asp?Gly?Ser?Gly?Ile?Gly?Leu?Ile?Leu?Thr?Asp

385 390 395 400

Tyr?Tyr?Gly?Arg?Pro?Ser?Lys?Arg?Gly?Gly?Ala?Trp?Met?Ser?Ser?Phe

405 410 415

Val?Asp?Gln?Ser?Glu?Leu?Leu?Gly?Thr?Lys?Pro?Val?Val?Val?Asn?Val

420 425 430

Met?Gly?Ile?Thr?Lys?Pro?Thr?Thr?Gly?Glu?Ala?Leu?Leu?Ser?Leu?Asp

435 440 445

Glu?Val?Thr?Thr?Ile?Phe?His?Glu?Phe?Gly?His?Gly?Leu?His?Gly?Leu

450 455 460

Leu?Ser?Lys?Val?Arg?Tyr?Pro?Ser?Phe?Ser?Gly?Thr?Ser?Val?Pro?Arg

465 470 475 480

Asp?Tyr?Val?Glu?Phe?Pro?Ser?Gln?Ile?Asn?Glu?Asn?Trp?Ala?Phe?Asp

485 490 495

Pro?Ala?Val?Val?Arg?Asn?Tyr?Ala?Arg?His?Val?Asp?Thr?Gly?Asp?Ile

500 505 510

Ile?Pro?Asp?Ser?Leu?Leu?Glu?Ala?Val?Glu?Ala?Cys?Gly?Ile?Ser?Asp

515 520 525

Arg?Val?Val?Glu?His?Val?Ser?Thr?Cys?Pro?His?Leu?Leu?Ser?Thr?Cys

530 535 540

Pro?Val?Ser?Pro?Cys?Pro?Gln?Arg?Met?Pro?His

545 550 555

<210>101

<211>1088

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(1065)

<223>FRXA00877

<400>101

gca?gca?gca?gtt?ggc?acc?gaa?ggc?tac?gtg?gtt?cca?ctg?gaa?ctg?ccc 48

Ala?Ala?Ala?Val?Gly?Thr?Glu?Gly?Tyr?Val?Val?Pro?Leu?Glu?Leu?Pro

1 5 10 15

acc?gtg?cag?tca?gag?cag?gca?gta?tta?acc?gaa?tcc?gcc?tcg?cgt?gca 96

Thr?Val?Gln?Ser?Glu?Gln?Ala?Val?Leu?Thr?Glu?Ser?Ala?Ser?Arg?Ala

20 25 30

aag?ctt?tat?gaa?gcc?tcc?cag?aag?cgt?ggc?gcc?agc?ctg?aac?aag?gac 144

Lys?Leu?Tyr?Glu?Ala?Ser?Gln?Lys?Arg?Gly?Ala?Ser?Leu?Asn?Lys?Asp

35 40 45

gtg?ctg?ctc?gaa?acc?gtg?cgt?ctg?cgt?gct?gaa?cgc?gcc?aca?ctt?tta 192

Val?Leu?Leu?Glu?Thr?Val?Arg?Leu?Arg?Ala?Glu?Arg?Ala?Thr?Leu?Leu

50 55 60

ggc?tac?gac?acc?cac?gcc?gat?tac?gtc?atc?gaa?gaa?gaa?acc?gcc?gat 240

Gly?Tyr?Asp?Thr?His?Ala?Asp?Tyr?Val?Ile?Glu?Glu?Glu?Thr?Ala?Asp

65 70 75 80

gac?gtc?gca?gcc?gtg?cgc?gcc?ttg?ctt?tat?gat?ctc?gcc?cca?gcc?gcc 288

Asp?Val?Ala?Ala?Val?Arg?Ala?Leu?Leu?Tyr?Asp?Leu?Ala?Pro?Ala?Ala

85 90 95

tct?gcc?aat?gcg?aaa?gcc?gaa?tac?aaa?ctc?tcc?gca?gaa?gaa?gca?gaa 336

Ser?Ala?Asn?Ala?Lys?Ala?Glu?Tyr?Lys?Leu?Ser?Ala?Glu?Glu?Ala?Glu

100 105 110

gaa?cac?ggc?caa?aaa?gtc?ggc?gca?gct?gac?tgg?agc?ttc?tgg?gaa?gcc 384

Glu?His?Gly?Gln?Lys?Val?Gly?Ala?Ala?Asp?Trp?Ser?Phe?Trp?Glu?Ala

115 120 125

aaa?gtc?cgc?gcc?cgc?gac?tac?gcc?ctg?gac?gaa?acc?gaa?ctg?cgc?aac 432

Lys?Val?Arg?Ala?Arg?Asp?Tyr?Ala?Leu?Asp?Glu?Thr?Glu?Leu?Arg?Asn

130 135 140

tacttc?cca?ttg?aac?caa?gta?ctc?cgt?gac?ggc?gtc?ttc?ttc?gct?gct 480

Tyr?Phe?Pro?Leu?Asn?Gln?Val?Leu?Arg?Asp?Gly?Val?Phe?Phe?Ala?Ala

145 150 155 160

aac?cgc?ctc?tac?gga?atc?acc?gtg?gaa?cca?cgc?cct?gac?ctg?cgc?ggt 528

Asn?Arg?Leu?Tyr?Gly?Ile?Thr?Val?Glu?Pro?Arg?Pro?Asp?Leu?Arg?Gly

165 170 175

tac?gcc?gag?ggc?gtg?gac?gtc?tgg?gaa?gtc?ctc?gat?tct?gac?ggc?tcc 576

Tyr?Ala?Glu?Gly?Val?Asp?Val?Trp?Glu?Val?Leu?Asp?Ser?Asp?Gly?Ser

180 185 190

ggc?atc?ggc?ctg?atc?ctt?acc?gac?tac?tac?ggc?cga?cca?tcc?aag?cgg 624

Gly?Ile?Gly?Leu?Ile?Leu?Thr?Asp?Tyr?Tyr?Gly?Arg?Pro?Ser?Lys?Arg

195 200 205

ggc?ggc?gct?tgg?atg?tcc?agc?ttt?gtc?gac?caa?tcc?gag?ctg?cta?ggc 672

Gly?Gly?Ala?Trp?Met?Ser?Ser?Phe?Val?Asp?Gln?Ser?Glu?Leu?Leu?Gly

210 215 220

acc?aag?cca?gtc?gtg?gtc?aac?gtt?atg?ggt?att?acc?aaa?cca?acc?acc 720

Thr?Lys?Pro?Val?Val?Val?Asn?Val?Met?Gly?Ile?Thr?Lys?Pro?Thr?Thr

225 230 235 240

ggc?gaa?gca?cta?ctc?agc?ctc?gat?gaa?gta?acc?acc?atc?ttc?cac?gaa 768

Gly?Glu?Ala?Leu?Leu?Ser?Leu?Asp?Glu?Val?Thr?Thr?Ile?Phe?His?Glu

245 250 255

ttc?ggc?cac?ggc?ctg?cac?ggc?ttg?ctg?tcc?aag?gtg?cgc?tac?cca?agc 816

Phe?Gly?His?Gly?Leu?His?Gly?Leu?Leu?Ser?Lys?Val?Arg?Tyr?Pro?Ser

260 265 270

ttc?tcc?gga?acc?tcc?gtg?ccc?cgc?gac?tac?gta?gaa?ttc?ccc?tcc?cag 864

Phe?Ser?Gly?Thr?Ser?Val?Pro?Arg?Asp?Tyr?Val?Glu?Phe?Pro?Ser?Gln

275 280 285

atc?aac?gaa?aac?tgg?gca?ttc?gac?cct?gca?gta?gtc?cgc?aac?tac?gcc 912

Ile?Asn?Glu?Asn?Trp?Ala?Phe?Asp?Pro?Ala?Val?Val?Arg?Asn?Tyr?Ala

290 295 300

cgc?cac?gtg?gac?acc?ggc?gac?atc?att?cca?gac?tcc?ctg?ctt?gag?gca 960

Arg?His?Val?Asp?Thr?Gly?Asp?Ile?Ile?Pro?Asp?Ser?Leu?Leu?Glu?Ala

305 310 315 320

gtg?gaa?gca?tgt?ggc?att?tca?gac?aga?gtg?gtg?gaa?cat?gtg?agt?act 1008

Val?Glu?Ala?Cys?Gly?Ile?Ser?Asp?Arg?Val?Val?Glu?His?Val?Ser?Thr

325 330 335

tgt?ccc?cat?cta?tta?tcg?acc?tgc?cct?gtc?tct?ccc?tgt?cca?cag?cgg 1056

Cys?Pro?His?Leu?Leu?Ser?Thr?Cys?Pro?Val?Ser?Pro?Cys?Pro?Gln?Arg

340 345 350

atg?ccg?cac?tagtcaatga?cattgaccaa?tta 1088

Met?Pro?His

355

<210>102

<211>355

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>102

Ala?Ala?Ala?Val?Gly?Thr?Glu?Gly?Tyr?Val?Val?Pro?Leu?Glu?Leu?Pro

1 5 10 15

Thr?Val?Gln?Ser?Glu?Gln?Ala?Val?Leu?Thr?Glu?Ser?Ala?Ser?Arg?Ala

20 25 30

Lys?Leu?Tyr?Glu?Ala?Ser?Gln?Lys?Arg?Gly?Ala?Ser?Leu?Asn?Lys?Asp

35 40 45

Val?Leu?Leu?Glu?Thr?Val?Arg?Leu?Arg?Ala?Glu?Arg?Ala?Thr?Leu?Leu

50 55 60

Gly?Tyr?Asp?Thr?His?Ala?Asp?Tyr?Val?Ile?Glu?Glu?Glu?Thr?Ala?Asp

65 70 75 80

Asp?Val?Ala?Ala?Val?Arg?Ala?Leu?Leu?Tyr?Asp?Leu?Ala?Pro?Ala?Ala

85 90 95

Ser?Ala?Asn?Ala?Lys?Ala?Glu?Tyr?Lys?Leu?Ser?Ala?Glu?Glu?Ala?Glu

100 105 110

Glu?His?Gly?Gln?Lys?Val?Gly?Ala?Ala?Asp?Trp?Ser?Phe?Trp?Glu?Ala

115 120 125

Lys?Val?Arg?Ala?Arg?Asp?Tyr?Ala?Leu?Asp?Glu?Thr?Glu?Leu?Arg?Asn

130 135 140

Tyr?Phe?Pro?Leu?Asn?Gln?Val?Leu?Arg?Asp?Gly?Val?Phe?Phe?Ala?Ala

145 150 155 160

Asn?Arg?Leu?Tyr?Gly?Ile?Thr?Val?Glu?Pro?Arg?Pro?Asp?Leu?Arg?Gly

165 170 175

Tyr?Ala?Glu?Gly?Val?Asp?Val?Trp?Glu?Val?Leu?Asp?Ser?Asp?Gly?Ser

180 185 190

Gly?Ile?Gly?Leu?Ile?Leu?Thr?Asp?Tyr?Tyr?Gly?Arg?Pro?Ser?Lys?Arg

195 200 205

Gly?Gly?Ala?Trp?Met?Ser?Ser?Phe?Val?Asp?Gln?Ser?Glu?Leu?Leu?Gly

210 215 220

Thr?Lys?Pro?Val?Val?Val?Asn?Val?Met?Gly?Ile?Thr?Lys?Pro?Thr?Thr

225 230 235 240

Gly?Glu?Ala?Leu?Leu?Ser?Leu?Asp?Glu?Val?Thr?Thr?Ile?Phe?His?Glu

245 250 255

Phe?Gly?His?Gly?Leu?His?Gly?Leu?Leu?Ser?Lys?Val?Arg?Tyr?Pro?Ser

260 265 270

Phe?Ser?Gly?Thr?Ser?Val?Pro?Arg?Asp?Tyr?Val?Glu?Phe?Pro?Ser?Gln

275 280 285

Ile?Asn?Glu?Asn?Trp?Ala?Phe?Asp?Pro?Ala?Val?Val?Arg?Asn?Tyr?Ala

290 295 300

Arg?His?Val?Asp?Thr?Gly?Asp?Ile?Ile?Pro?Asp?Ser?Leu?Leu?Glu?Ala

305 310 315 320

Val?Glu?Ala?Cys?Gly?Ile?Ser?Asp?Arg?Val?Val?Glu?His?Val?Ser?Thr

325 330 335

Cys?Pro?His?Leu?Leu?Ser?Thr?Cys?Pro?Val?Ser?Pro?Cys?Pro?Gln?Arg

340 345 350

Met?Pro?His

355

<210>103

<211>2724

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(2701)

<223>RXN01014

<400>103

tcttaaagtt?ttctagcaat?ccacactagg?cgcgaactat?cgtggtgtca?ttgcgcacct?60

tctaagggta?gcgccccctc?aaatttcaag?gagcattaaa?ttg?acg?tcc?act?aat 115

Leu?Thr?Ser?Thr?Asn

1 5

ctc?acc?cga?cag?gaa?gct?tcg?gat?cgt?tcg?agg?tta?ctg?agt?gta?gaa 163

Leu?Thr?Arg?Gln?Glu?Ala?Ser?Asp?Arg?Ser?Arg?Leu?Leu?Ser?Val?Glu

10 15 20

aac?tat?gac?att?gca?ctt?gat?ctc?aac?aac?ggt?gat?gag?ttt?ttt?agt 211

Asn?Tyr?Asp?Ile?Ala?Leu?Asp?Leu?Asn?Asn?Gly?Asp?Glu?Phe?Phe?Ser

25 30 35

tcc?tcc?acc?gtt?gtc?agc?ttc?act?gtc?agg?aag?gct?ggc?gat?acc?ttt 259

Ser?Ser?Thr?Val?Val?Ser?Phe?Thr?Val?Arg?Lys?Ala?Gly?Asp?Thr?Phe

40 45 50

att?gat?ctc?cgc?gca?gca?agc?gtt?gag?gag?gtt?cgc?ctg?gac?aat?gtg 307

Ile?Asp?Leu?Arg?Ala?Ala?Ser?Val?Glu?Glu?Val?Arg?Leu?Asp?Asn?Val

55 60 65

tcc?atc?aaa?gat?gag?gct?cta?acc?ctt?ggc?aag?aac?ggc?tac?gac?gag 355

Ser?Ile?Lys?Asp?Glu?Ala?Leu?Thr?Leu?Gly?Lys?Asn?Gly?Tyr?Asp?Glu

70 75 80 85

acg?ttc?ggc?atc?gcc?ctg?aag?ggt?ctt?act?ccc?ggc?gcg?cac?acc?ttg 403

Thr?Phe?Gly?Ile?Ala?Leu?Lys?Gly?Leu?Thr?Pro?Gly?Ala?His?Thr?Leu

90 95 100

cgg?gta?acg?gcg?tct?atc?ccc?tat?tcc?cgc?acc?ggt?gaa?ggc?ctg?cac 451

Arg?Val?Thr?Ala?Ser?Ile?Pro?Tyr?Ser?Arg?Thr?Gly?Glu?Gly?Leu?His

105 110 115

cgc?atg?gtg?gat?cca?gca?gac?aat?gag?gtg?tat?ttg?tac?acc?cag?ttt 499

Arg?Met?Val?Asp?Pro?Ala?Asp?Asn?Glu?Val?Tyr?Leu?Tyr?Thr?Gln?Phe

120 125 130

gag?acc?gcc?gat?gcc?aag?cgt?atg?ttc?gcg?tgt?ttc?gat?cag?cca?gac 547

Glu?Thr?Ala?Asp?Ala?Lys?Arg?Met?Phe?Ala?Cys?Phe?Asp?Gln?Pro?Asp

135 140 145

ctc?aag?gct?acc?tat?gat?ctg?aac?atc?aaa?act?cct?aag?ggt?tgg?aag 595

Leu?Lys?Ala?Thr?Tyr?Asp?Leu?Asn?Ile?Lys?Thr?Pro?Lys?Gly?Trp?Lys

150 155 160 165

atc?att?tcc?aac?tct?gag?cag?cag?gtt?tcc?act?cag?cac?act?gat?tac 643

Ile?Ile?Ser?Asn?Ser?Glu?Gln?Gln?Val?Ser?Thr?Gln?His?Thr?Asp?Tyr

170 175 180

gat?acc?cac?att?tcc?cga?gtg?gac?tat?ccc?ctc?tcc?acc?tac?ctg?att 691

Asp?Thr?His?Ile?Ser?Arg?Val?Asp?Tyr?Pro?Leu?Ser?Thr?Tyr?Leu?Ile

185 190 195

gcg?gtg?tgc?gcg?ggt?cgt?tac?cac?gag?gtg?tgc?gat?gtc?tgg?aag?ggt 739

Ala?Val?Cys?Ala?Gly?Arg?Tyr?His?Glu?Val?Cys?Asp?Val?Trp?Lys?Gly

200 205 210

acg?ctc?acc?cac?cat?gca?gaa?aca?cct?gcc?gat?cag?cca?act?gag?ctg 787

Thr?Leu?Thr?His?His?Ala?Glu?Thr?Pro?Ala?Asp?Gln?Pro?Thr?Glu?Leu

215 220 225

act?gtt?ccg?ctt?gct?ctc?tac?tgc?cgc?agt?tct?ttg?gct?aaa?gat?ctt 835

Thr?Val?Pro?Leu?Ala?Leu?Tyr?Cys?Arg?Ser?Ser?Leu?Ala?Lys?Asp?Leu

230 235 240 245

gat?gcg?gtg?cgt?ctg?ttt?acc?gaa?acg?aag?cag?ggc?ttt?gat?tgg?tac 883

Asp?Ala?Val?Arg?Leu?Phe?Thr?Glu?Thr?Lys?Gln?Gly?Phe?Asp?Trp?Tyr

250 255 260

cac?cgc?aac?ttc?ggt?gtg?gcg?tac?cca?ttc?ggc?aag?tac?gat?cag?atc 931

His?Arg?Asn?Phe?Gly?Val?Ala?Tyr?Pro?Phe?Gly?Lys?Tyr?Asp?Gln?Ile

265 270 275

ttc?gtc?cct?gaa?ttt?aat?gct?ggc?gcg?atg?gag?aac?gcc?ggc?gct?gtc 979

Phe?Val?Pro?Glu?Phe?Asn?Ala?Gly?Ala?Met?Glu?Asn?Ala?Gly?Ala?Val

280 285 290

acc?atc?cgc?gat?gag?tac?gtt?ttt?gca?tcc?aag?gca?acc?cgt?tac?cgc 1027

Thr?Ile?Arg?Asp?Glu?Tyr?Val?Phe?Ala?Ser?Lys?Ala?Thr?Arg?Tyr?Arg

295 300 305

tac?gag?cgc?cgc?gct?gaa?acc?atc?ctt?cac?gag?ctc?gct?cac?atg?tgg 1075

Tyr?Glu?Arg?Arg?Ala?Glu?Thr?Ile?Leu?His?Glu?Leu?Ala?His?Met?Trp

310 315 320 325

ttc?ggt?gtg?ctg?gtg?acc?atg?cag?tgg?tgg?gat?gat?ctg?tgg?ctc?aac 1123

Phe?Gly?Val?Leu?Val?Thr?Met?Gln?Trp?Trp?Asp?Asp?Leu?Trp?Leu?Asn

330 335 340

gag?tcc?ttc?gcc?act?tgg?tcc?gcg?gca?att?tct?cag?gct?gag?gaa?act 1171

Glu?Ser?Phe?Ala?Thr?Trp?Ser?Ala?Ala?Ile?Ser?Gln?Ala?Glu?Glu?Thr

345 350 355

gaa?tac?aac?act?gca?tgg?gtg?act?ttc?gcc?aat?gtg?gag?aag?tcg?tgg 1219

Glu?Tyr?Asn?Thr?Ala?Trp?Val?Thr?Phe?Ala?Asn?Val?Glu?Lys?Ser?Trp

360 365 370

gcg?tac?cag?cag?gat?cag?ctg?cct?tcc?acc?cac?ccg?gtg?ttc?tct?gac 1267

Ala?Tyr?Gln?Gln?Asp?Gln?Leu?Pro?Ser?Thr?His?Pro?Val?Phe?Ser?Asp

375 380 385

gga?tac?gac?att?gag?act?gtc?gac?cag?aac?ttc?gac?ggc?atc?acc?tac 1315

Gly?Tyr?Asp?Ile?Glu?Thr?Val?Asp?Gln?Asn?Phe?Asp?Gly?Ile?Thr?Tyr

390 395 400 405

gca?aag?ggc?gcc?tcg?gtg?ctc?aag?cag?ctg?cag?gca?tac?gtt?ggc?cgt 1363

Ala?Lys?Gly?Ala?Ser?Val?Leu?Lys?Gln?Leu?Gln?Ala?Tyr?Val?Gly?Arg

410 415 420

gag?gaa?ttc?ctg?gca?ggc?gta?cgc?agg?cac?ttt?gcc?aac?cac?gca?tgg 1411

Glu?Glu?Phe?Leu?Ala?Gly?Val?Arg?Arg?His?Phe?Ala?Asn?His?Ala?Trp

425 430 435

ggc?aac?gcc?agc?ttt?gat?gat?ctg?ctc?ggc?gcc?ctc?gag?cag?tcc?tcc 1459

Gly?Asn?Ala?Ser?Phe?Asp?Asp?Leu?Leu?Gly?Ala?Leu?Glu?Gln?Ser?Ser

440 445 450

ggc?cgc?gac?ctc?tcc?gac?tgg?gca?aac?cag?tgg?ctc?aag?acc?acc?ggc 1507

Gly?Arg?Asp?Leu?Ser?Asp?Trp?Ala?Asn?Gln?Trp?Leu?Lys?Thr?Thr?Gly

455 460 465

atc?aac?acc?ctc?ggc?gca?aag?ttc?acc?acc?gac?aac?ggc?aaa?tac?acc 1555

Ile?Asn?Thr?Leu?Gly?Ala?Lys?Phe?Thr?Thr?Asp?Asn?Gly?Lys?Tyr?Thr

470 475 480 485

tcc?ttc?tcc?gtc?acc?cag?acc?ggc?gcc?gcg?ccg?ggt?gcc?ggt?gag?ctg 1603

Ser?phe?Ser?Val?Thr?Gln?Thr?Gly?Ala?Ala?Pro?Gly?Ala?Gly?Glu?Leu

490 495 500

cgg?act?cac?cgc?atc?gcg?gtg?ggt?ctt?tat?aag?ctt?gtc?gac?gga?tcc 1651

Arg?Thr?His?Arg?Ile?Ala?Val?Gly?Leu?Tyr?Lys?Leu?Val?Asp?Gly?Ser

505 510 515

ctc?aac?cgc?tac?gca?cga?gta?gaa?ctt?gac?tgc?agt?ggc?gcg?tcg?aca 1699

Leu?Asn?Arg?Tyr?Ala?Arg?Val?Glu?Leu?Asp?Cys?Ser?Gly?Ala?Ser?Thr

520 525 530

agc?gtt?gaa?gag?atc?gtt?gga?ctt?gag?cag?gct?gac?ttc?gtg?ctg?gtc 1747

Ser?Val?Glu?Glu?Ile?Val?Gly?Leu?Glu?Gln?Ala?Asp?Phe?Val?Leu?Val

535 540 545

aac?gat?gat?gat?ctg?acg?tat?gcg?ctg?ctg?gat?ctg?gat?gat?gat?tca 1795

Asn?Asp?Asp?Asp?Leu?Thr?Tyr?Ala?Leu?Leu?Asp?Leu?Asp?Asp?Asp?Ser

550 555 560 565

cgc?aat?ttt?gtc?atc?gac?aat?att?gat?aag?ttc?agc?gac?cct?atg?cct 1843

Arg?Asn?Phe?Val?Ile?Asp?Asn?Ile?Asp?Lys?Phe?Ser?Asp?Pro?Met?Pro

570 575 580

cgc?acg?ctg?gtg?tgg?tcc?gct?gcg?tgg?gag?atg?act?cgc?gct?ggt?cag 1891

Arg?Thr?Leu?Val?Trp?Ser?Ala?Ala?Trp?Glu?Met?Thr?Arg?Ala?Gly?Gln

585 590 595

atg?aag?gct?cgt?gat?ttc?atc?gcg?ctg?gtt?gct?cgt?ggc?gct?gct?gcg 1939

Met?Lys?Ala?Arg?Asp?Phe?Ile?Ala?Leu?Val?Ala?Arg?Gly?Ala?Ala?Ala

600 605 610

gaa?act?gaa?att?gct?gtg?ctg?gag?cgc?att?ctc?gcg?cag?gct?acc?tct 1987

Glu?Thr?Glu?Ile?Ala?Val?Leu?Glu?Arg?Ile?Leu?Ala?Gln?Ala?Thr?Ser

615 620 625

gcg?ctg?aag?agc?tac?gcc?gac?cca?gcg?tgg?gca?gaa?gca?act?gga?aat 2035

Ala?Leu?Lys?Ser?Tyr?Ala?Asp?Pro?Ala?Trp?Ala?Glu?Ala?Thr?Gly?Asn

630 635 640 645

gac?ctg?ctg?gcc?gat?gct?ttc?ctt?gag?ggt?gct?cgc?tcc?gca?gaa?cca 2083

Asp?Leu?Leu?Ala?Asp?Ala?Phe?Leu?Glu?Gly?Ala?Arg?Ser?Ala?Glu?Pro

650 655 660

gac?tcc?gac?act?cag?ttg?gcg?ttc?att?cag?gct?ctg?gca?aaa?gca?acg 2131

Asp?Ser?Asp?Thr?Gln?Leu?Ala?Phe?Ile?Gln?Ala?Leu?Ala?Lys?Ala?Thr

665 670 675

ctc?aat?gat?gct?gct?gcc?gat?tac?ttc?cgc?gac?att?ctt?gcc?ggc?aac 2179

Leu?Asn?Asp?Ala?Ala?Ala?Asp?Tyr?Phe?Arg?Asp?Ile?Leu?Ala?Gly?Asn

680 685 690

gtc?gaa?ggc?ctg?acc?gtg?gat?cct?gac?ctg?cgt?tgg?tgg?gca?ctg?act 2227

Val?Glu?Gly?Leu?Thr?Val?Asp?Pro?Asp?Leu?Arg?Trp?Trp?Ala?Leu?Thr

695 700 705

gcg?ctt?atc?gcc?cgt?ggt?gac?atc?gag?gct?gtc?gaa?gat?gca?atc?gcc 2275

Ala?Leu?Ile?Ala?Arg?Gly?Asp?Ile?Glu?Ala?Val?Glu?Asp?Ala?Ile?Ala

710 715 720 725

gct?gaa?ctt?tcc?cgc?gac?aac?tcc?agt?gcc?tcc?ttc?ctc?gca?tca?ctt 2323

Ala?Glu?Leu?Ser?Arg?Asp?Asn?Ser?Ser?Ala?Ser?Phe?Leu?Ala?Ser?Leu

730 735 740

cga?gcc?ggt?gcc?gct?gtg?aac?act?gaa?gaa?gtg?aag?gct?gct?gca?tac 2371

Arg?Ala?Gly?Ala?Ala?Val?Asn?Thr?Glu?Glu?Val?Lys?Ala?Ala?Ala?Tyr

745 750 755

aag?cat?gtc?acg?gca?gtt?gat?agt?ggc?cta?tcc?aac?ctg?gag?ctg?cgc 2419

Lys?His?Val?Thr?Ala?Val?Asp?Ser?Gly?Leu?Ser?Asn?Leu?Glu?Leu?Arg

760 765 770

cac?aag?att?gaa?ggc?ctc?aca?ttc?act?ggc?tct?tct?gaa?ctg?ctg?caa 2467

His?Lys?Ile?Glu?Gly?Leu?Thr?Phe?Thr?Gly?Ser?Ser?Glu?Leu?Leu?Gln

775 780 785

gcc?tac?aac?gag?cag?tac?ttc?gaa?atc?ctt?gat?gat?gtg?tgg?gcg?aac 2515

Ala?Tyr?Asn?Glu?Gln?Tyr?Phe?Glu?Ile?Leu?Asp?Asp?Val?Trp?Ala?Asn

790 795 800 805

ttc?tcc?ggc?gaa?atg?gca?cag?cag?atc?gtc?ctc?gga?ctg?ttc?cct?tca 2563

Phe?Ser?Gly?Glu?Met?Ala?Gln?Gln?Ile?Val?Leu?Gly?Leu?Phe?Pro?Ser

810 815 820

tgg?aac?gtt?tcc?gaa?gag?ggt?ctc?aag?cgt?acc?gac?gag?ttt?ctt?gat 2611

Trp?Asn?Val?Ser?Glu?Glu?Gly?Leu?Lys?Arg?Thr?Asp?Glu?Phe?Leu?Asp

825 830 835

ggc?gaa?cat?gtc?gca?ggc?atc?aag?cga?att?gtt?tcc?gaa?tcc?ctc?gac 2659

Gly?Glu?His?Val?Ala?Gly?Ile?Lys?Arg?Ile?Val?Ser?Glu?Ser?Leu?Asp

840 845 850

cgc?act?gcc?cgt?gct?ctg?cgc?aac?cgt?gcg?gca?gat?gct?gcg 2701

Arg?Thr?Ala?Arg?Ala?Leu?Arg?Asn?Arg?Ala?Ala?Asp?Ala?Ala

855 860 865

taagtaaaag?attctcaatc?cca 2724

<210>104

<211>867

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>104

Leu?Thr?Ser?Thr?Asn?Leu?Thr?Arg?Gln?Glu?Ala?Ser?Asp?Arg?Ser?Arg

1 5 10 15

Leu?Leu?Ser?Val?Glu?Asn?Tyr?Asp?Ile?Ala?Leu?Asp?Leu?Asn?Asn?Gly

20 25 30

Asp?Glu?Phe?Phe?Ser?Ser?Ser?Thr?Val?Val?Ser?Phe?Thr?Val?Arg?Lys

35 40 45

Ala?Gly?Asp?Thr?Phe?Ile?Asp?Leu?Arg?Ala?Ala?Ser?Val?Glu?Glu?Val

50 55 60

Arg?Leu?Asp?Asn?Val?Ser?Ile?Lys?Asp?Glu?Ala?Leu?Thr?Leu?Gly?Lys

65 70 75 80

Asn?Gly?Tyr?Asp?Glu?Thr?Phe?Gly?Ile?Ala?Leu?Lys?Gly?Leu?Thr?Pro

85 90 95

Gly?Ala?His?Thr?Leu?Arg?Val?Thr?Ala?Ser?Ile?Pro?Tyr?Ser?Arg?Thr

100 105 110

Gly?Glu?Gly?Leu?His?Arg?Met?Val?Asp?Pro?Ala?Asp?Asn?Glu?Val?Tyr

115 120 125

Leu?Tyr?Thr?Gln?Phe?Glu?Thr?Ala?Asp?Ala?Lys?Arg?Met?Phe?Ala?Cys

130 135 140

Phe?Asp?Gln?Pro?Asp?Leu?Lys?Ala?Thr?Tyr?Asp?Leu?Asn?Ile?Lys?Thr

145 150 155 160

Pro?Lys?Gly?Trp?Lys?Ile?Ile?Ser?Asn?Ser?Glu?Gln?Gln?Val?Ser?Thr

165 170 175

Gln?His?Thr?Asp?Tyr?Asp?Thr?His?Ile?Ser?Arg?Val?Asp?Tyr?Pro?Leu

180 185 190

Ser?Thr?Tyr?Leu?Ile?Ala?Val?Cys?Ala?Gly?Arg?Tyr?His?Glu?Val?Cys

195 200 205

Asp?Val?Trp?Lys?Gly?Thr?Leu?Thr?His?His?Ala?Glu?Thr?Pro?Ala?Asp

210 215 220

Gln?Pro?Thr?Glu?Leu?Thr?Val?Pro?Leu?Ala?Leu?Tyr?Cys?Arg?Ser?Ser

225 230 235 240

Leu?Ala?Lys?Asp?Leu?Asp?Ala?Val?Arg?Leu?Phe?Thr?Glu?Thr?Lys?Gln

245 250 255

Gly?Phe?Asp?Trp?Tyr?His?Arg?Asn?Phe?Gly?Val?Ala?Tyr?Pro?Phe?Gly

260 265 270

Lys?Tyr?Asp?Gln?Ile?Phe?Val?Pro?Glu?Phe?Asn?Ala?Gly?Ala?Met?Glu

275 280 285

Asn?Ala?Gly?Ala?Val?Thr?Ile?Arg?Asp?Glu?Tyr?Val?Phe?Ala?Ser?Lys

290 295 300

Ala?Thr?Arg?Tyr?Arg?Tyr?Glu?Arg?Arg?Ala?Glu?Thr?Ile?Leu?His?Glu

305 310 315 320

Leu?Ala?His?Met?Trp?Phe?Gly?Val?Leu?Val?Thr?Met?Gln?Trp?Trp?Asp

325 330 335

Asp?Leu?Trp?Leu?Asn?Glu?Ser?Phe?Ala?Thr?Trp?Ser?Ala?Ala?Ile?Ser

340 345 350

Gln?Ala?Glu?Glu?Thr?Glu?Tyr?Asn?Thr?Ala?Trp?Val?Thr?Phe?Ala?Asn

355 360 365

Val?Glu?Lys?Ser?Trp?Ala?Tyr?Gln?Gln?Asp?Gln?Leu?Pro?Ser?Thr?His

370 375 380

Pro?Val?Phe?Ser?Asp?Gly?Tyr?Asp?lle?Glu?Thr?Val?Asp?Gln?Asn?Phe

385 390 395 400

Asp?Gly?Ile?Thr?Tyr?Ala?Lys?Gly?Ala?Ser?Val?Leu?Lys?Gln?Leu?Gln

405 410 415

Ala?Tyr?Val?Gly?Arg?Glu?Glu?Phe?Leu?Ala?Gly?Val?Arg?Arg?His?Phe

420 425 430

Ala?Asn?His?Ala?Trp?Gly?Asn?Ala?Ser?Phe?Asp?Asp?Leu?Leu?Gly?Ala

435 440 445

Leu?Glu?Gln?Ser?Ser?Gly?Arg?Asp?Leu?Ser?Asp?Trp?Ala?Asn?Gln?Trp

450 455 460

Leu?Lys?Thr?Thr?Gly?Ile?Asn?Thr?Leu?Gly?Ala?Lys?Phe?Thr?Thr?Asp

465 470 475 480

Asn?Gly?Lys?Tyr?Thr?Ser?Phe?Ser?Val?Thr?Gln?Thr?Gly?Ala?Ala?Pro

485 490 495

Gly?Ala?Gly?Glu?Leu?Arg?Thr?His?Arg?Ile?Ala?Val?Gly?Leu?Tyr?Lys

500 505 510

Leu?Val?Asp?Gly?Ser?Leu?Asn?Arg?Tyr?Ala?Arg?Val?Glu?Leu?Asp?Cys

515 520 525

Ser?Gly?Ala?Ser?Thr?Ser?Val?Glu?Glu?Ile?Val?Gly?Leu?Glu?Gln?Ala

530 535 540

Asp?Phe?Val?Leu?Val?Asn?Asp?Asp?Asp?Leu?Thr?Tyr?Ala?Leu?Leu?Asp

545 550 555 560

Leu?Asp?Asp?Asp?Ser?Arg?Asn?Phe?Val?Ile?Asp?Asn?Ile?Asp?Lys?Phe

565 570 575

Ser?Asp?Pro?Met?Pro?Arg?Thr?Leu?Val?Trp?Ser?Ala?Ala?Trp?Glu?Met

580 585 590

Thr?Arg?Ala?Gly?Gln?Met?Lys?Ala?Arg?Asp?Phe?Ile?Ala?Leu?Val?Ala

595 600 605

Arg?Gly?Ala?Ala?Ala?Glu?Thr?Glu?Ile?Ala?Val?Leu?Glu?Arg?Ile?Leu

610 615 620

Ala?Gln?Ala?Thr?Ser?Ala?Leu?Lys?Ser?Tyr?Ala?Asp?Pro?Ala?Trp?Ala

625 630 635 640

Glu?Ala?Thr?Gly?Asn?Asp?Leu?Leu?Ala?Asp?Ala?Phe?Leu?Glu?Gly?Ala

645 650 655

Arg?Ser?Ala?Glu?Pro?Asp?Ser?Asp?Thr?Gln?Leu?Ala?Phe?Ile?Gln?Ala

660 665 670

Leu?Ala?Lys?Ala?Thr?Leu?Asn?Asp?Ala?Ala?Ala?Asp?Tyr?Phe?Arg?Asp

675 680 685

Ile?Leu?Ala?Gly?Asn?Val?Glu?Gly?Leu?Thr?Val?Asp?Pro?Asp?Leu?Arg

690 695 700

Trp?Trp?Ala?Leu?Thr?Ala?Leu?Ile?Ala?Arg?Gly?Asp?Ile?Glu?Ala?Val

705 710 715 720

Glu?Asp?Ala?Ile?Ala?Ala?Glu?Leu?Ser?Arg?Asp?Asn?Ser?Ser?Ala?Ser

725 730 735

Phe?Leu?Ala?Ser?Leu?Arg?Ala?Gly?Ala?Ala?Val?Asn?Thr?Glu?Glu?Val

740 745 750

Lys?Ala?Ala?Ala?Tyr?Lys?His?Val?Thr?Ala?Val?Asp?Ser?Gly?Leu?Ser

755 760 765

Asn?Leu?Glu?Leu?Arg?His?Lys?Ile?Glu?Gly?Leu?Thr?Phe?Thr?Gly?Ser

770 775 780

Ser?Glu?Leu?Leu?Gln?Ala?Tyr?Asn?Glu?Gln?Tyr?Phe?Glu?Ile?Leu?Asp

785 790 795 800

Asp?Val?Trp?Ala?Asn?Phe?Ser?Gly?Glu?Met?Ala?Gln?Gln?Ile?Val?Leu

805 810 815

Gly?Leu?phe?Pro?Ser?Trp?Asn?Val?Ser?Glu?Glu?Gly?Leu?Lys?Arg?Thr

820 825 830

Asp?Glu?Phe?Leu?Asp?Gly?Glu?His?Val?Ala?Gly?Ile?Lys?Arg?Ile?Val

835 840 845

Ser?Glu?Ser?Leu?Asp?Arg?Thr?Ala?Arg?Ala?Leu?Arg?Asn?Arg?Ala?Ala

850 855 860

Asp?Ala?Ala

865

<210>105

<211>1578

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(1578)

<223>FRXA01014

<400>105

gat?gat?ctg?tgg?ctc?aac?gag?tcc?ttc?gcc?act?tgg?tcc?gcg?gca?att 48

Asp?Asp?Leu?Trp?Leu?Asn?Glu?Ser?Phe?Ala?Thr?Trp?Ser?Ala?Ala?Ile

1 5 10 15

tct?cag?gct?gag?gaa?act?gaa?tac?aac?act?gca?tgg?gtg?act?ttc?gcc 96

Ser?Gln?Ala?Glu?Glu?Thr?Glu?Tyr?Asn?Thr?Ala?Trp?Val?Thr?Phe?Ala

20 25 30

aat?gtg?gag?aag?tcg?tgg?gcg?tac?cag?cag?gat?cag?ctg?cct?tcc?acc 144

Asn?Val?Glu?Lys?Ser?Trp?Ala?Tyr?Gln?Gln?Asp?Gln?Leu?Pro?Ser?Thr

35 40 45

cac?ccg?gtg?ttc?tct?gac?gga?tac?gac?att?gag?act?gtc?gac?cag?aac 192

His?Pro?Val?Phe?Ser?Asp?Gly?Tyr?Asp?Ile?Glu?Thr?Val?Asp?Gln?Asn

50 55 60

ttc?gac?ggc?atc?acc?tac?gca?aag?ggc?gcc?tcg?gtg?ctc?aag?cag?ctg 240

Phe?Asp?Gly?Ile?Thr?Tyr?Ala?Lys?Gly?Ala?Ser?Val?Leu?Lys?Gln?Leu

65 70 75 80

cag?gca?tac?gtt?ggc?cgt?gag?gaa?ttc?ctg?gca?ggc?gta?cgc?agg?cac 288

Gln?Ala?Tyr?Val?Gly?Arg?Glu?Glu?Phe?Leu?Ala?Gly?Val?Arg?Arg?His

85 90 95

ttt?gcc?aac?cac?gca?tgg?ggc?aac?gcc?agc?ttt?gat?gat?ctg?ctc?ggc 336

Phe?Ala?Asn?His?Ala?Trp?Gly?Asn?Ala?Ser?Phe?Asp?Asp?Leu?Leu?Gly

100 105 110

gcc?ctc?gag?cag?tcc?tcc?ggc?cgc?gac?ctc?tcc?gac?tgg?gca?aac?cag 384

Ala?Leu?Glu?Gln?Ser?Ser?Gly?Arg?Asp?Leu?Ser?Asp?Trp?Ala?Asn?Gln

115 120 125

tgg?ctc?aag?acc?acc?ggc?atc?aac?acc?ctc?ggc?gca?aag?ttc?acc?acc 432

Trp?Leu?Lys?Thr?Thr?Gly?Ile?ASn?Thr?Leu?Gly?Ala?Lys?Phe?Thr?Thr

130 135 140

gac?aac?ggc?aaa?tac?acc?tcc?ttc?tcc?gtc?acc?cag?acc?ggc?gcc?gcg 480

Asp?Asn?Gly?Lys?Tyr?Thr?Ser?Phe?Ser?Val?Thr?Gln?Thr?Gly?Ala?Ala

145 150 155 160

ccg?ggt?gcc?ggt?gag?ctg?cgg?act?cac?cgc?atc?gcg?gtg?ggt?ctt?tat 528

Pro?Gly?Ala?Gly?Glu?Leu?Arg?Thr?His?Arg?Ile?Ala?Val?Gly?Leu?Tyr

165 170 175

aag?ctt?gtc?gac?gga?tcc?ctc?aac?cgc?tac?gca?cga?gta?gaa?ctt?gac 576

Lys?Leu?Val?Asp?Gly?Ser?Leu?Asn?Arg?Tyr?Ala?Arg?Val?Glu?Leu?Asp

180 185 190

tgc?agt?ggc?gcg?tcg?aca?agc?gtt?gaa?gag?atc?gtt?gga?ctt?gag?cag 624

Cys?Ser?Gly?Ala?Ser?Thr?Ser?Val?Glu?Glu?Ile?Val?Gly?Leu?Glu?Gln

195 200 205

gct?gac?ttc?gtg?ctg?gtc?aac?gat?gat?gat?ctg?acg?tat?gcg?ctg?ctg 672

Ala?Asp?Phe?Val?Leu?Val?Asn?Asp?Asp?Asp?Leu?Thr?Tyr?Ala?Leu?Leu

210 215 220

gat?ctg?gat?gat?gat?tca?cgc?aat?ttt?gtc?atc?gac?aat?att?gat?aag 720

Asp?Leu?Asp?Asp?Asp?Ser?Arg?Asn?Phe?Val?Ile?Asp?Asn?Ile?Asp?Lys

225 230 235 240

ttc?agc?gac?cct?atg?cct?cgc?acg?ctg?gtg?tgg?tcc?gct?gcg?tgg?gag 768

Phe?Ser?Asp?Pro?Met?Pro?Arg?Thr?Leu?Val?Trp?Ser?Ala?Ala?Trp?Glu

245 250 255

atg?act?cgc?gct?ggt?cag?atg?aag?gct?cgt?gat?ttc?atc?gcg?ctg?gtt 816

Met?Thr?Arg?Ala?Gly?Gln?Met?Lys?Ala?Arg?Asp?Phe?Ile?Ala?Leu?Val

260 265 270

gct?cgt?ggc?gct?gct?gcg?gaa?act?gaa?att?gct?gtg?ctg?gag?cgc?att 864

Ala?Arg?Gly?Ala?Ala?Ala?Glu?Thr?Glu?Ile?Ala?Val?Leu?Glu?Arg?Ile

275 280 285

ctc?gcg?cag?gct?acc?tct?gcg?ctg?aag?agc?tac?gcc?gac?cca?gcg?tgg 912

Leu?Ala?Gln?Ala?Thr?Ser?Ala?Leu?Lys?Ser?Tyr?Ala?Asp?Pro?Ala?Trp

290 295 300

gca?gaa?gca?act?gga?aat?gac?ctg?ctg?gcc?gat?gct?ttc?ctt?gag?ggt 960

Ala?Glu?Ala?Thr?Gly?Asn?Asp?Leu?Leu?Ala?Asp?Ala?Phe?Leu?Glu?Gly

305 310 315 320

gct?cgc?tcc?gca?gaa?cca?gac?tcc?gac?act?cag?ttg?gcg?ttc?att?cag 1008

Ala?Arg?Ser?Ala?Glu?Pro?Asp?Ser?Asp?Thr?Gln?Leu?Ala?Phe?Ile?Gln

325 330 335

gct?ctg?gca?aaa?gca?acg?ctc?aat?gat?gct?gct?gcc?gat?tac?ttc?cgc 1056

Ala?Leu?Ala?Lys?Ala?Thr?Leu?Asn?Asp?Ala?Ala?Ala?Asp?Tyr?Phe?Arg

340 345 350

gac?att?ctt?gcc?ggc?aac?gtc?gaa?ggc?ctg?acc?gtg?gat?cct?gac?ctg 1104

Asp?Ile?Leu?Ala?Gly?Asn?Val?Glu?Gly?Leu?Thr?Val?Asp?Pro?Asp?Leu

355 360 365

cgt?tgg?tgg?gca?ctg?act?gcg?ctt?atc?gcc?cgt?ggt?gac?atc?gag?gct 1152

Arg?Trp?Trp?Ala?Leu?Thr?Ala?Leu?Ile?Ala?Arg?Gly?Asp?Ile?Glu?Ala

370 375 380

gtc?gaa?gat?gca?atc?gcc?gct?gaa?ctt?tcc?cgc?gac?aac?tcc?agt?gcc 1200

Val?Glu?Asp?Ala?Ile?Ala?Ala?Glu?Leu?Ser?Arg?Asp?Asn?Ser?Ser?Ala

385 390 395 400

tcc?ttc?ctc?gca?tca?ctt?cga?gcc?ggt?gcc?gct?gtg?aac?act?gaa?gaa 1248

Ser?Phe?Leu?Ala?Ser?Leu?Arg?Ala?Gly?Ala?Ala?Val?Asn?Thr?Glu?Glu

405 410 415

gtg?aag?gct?gct?gca?tac?aag?cat?gtc?ccg?gca?gtt?gat?agt?ggc?cta 1296

Val?Lys?Ala?Ala?Ala?Tyr?Lys?His?Val?Pro?Ala?Val?Asp?Ser?Gly?Leu

420 425 430

tcc?aac?ctg?gag?ctg?cgc?cac?aag?att?gaa?ggc?ctc?aca?ttc?act?ggc 1344

Ser?Asn?Leu?Glu?Leu?Arg?His?Lys?Ile?Glu?Gly?Leu?Thr?phe?Thr?Gly

435 440 445

tct?ttt?gaa?ctg?ctg?caa?gcc?tac?aac?gag?cag?tac?ttc?gaa?atc?ctt 1392

Ser?Phe?Glu?Leu?Leu?Gln?Ala?Tyr?Asn?Glu?Gln?Tyr?Phe?Glu?Ile?Leu

450 455 460

gat?gat?gtg?tgg?gcg?aac?ttc?tcc?ggc?gaa?atg?gca?cag?cag?atc?gtc 1440

Asp?Asp?Val?Trp?Ala?Asn?Phe?Ser?Gly?Glu?Met?Ala?Gln?Gln?Ile?Val

465 470 475 480

ctc?gga?ctg?ttc?cct?tca?tgg?aac?gtt?tcc?gaa?gag?ggt?ctc?aag?cgt 1488

Leu?Gly?Leu?Phe?Pro?Ser?Trp?Ash?Val?Ser?Glu?Glu?Gly?Leu?Lys?Arg

485 490 495

acc?gac?gag?ttt?ctt?gat?ggc?gaa?cat?gtc?gca?ggc?atc?aag?cga?att 1536

Thr?Asp?Glu?Phe?Leu?Asp?Gly?Glu?His?Val?Ala?Gly?Ile?Lys?Arg?Ile

500 505 510

gtt?tcc?gaa?tcc?ctc?gac?cgc?act?gcc?cgt?gct?ctg?cgc?aac 1578

Val?Ser?Glu?Ser?Leu?Asp?Arg?Thr?Ala?Arg?Ala?Leu?Arg?Asn

515 520 525

<210>106

<211>526

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>106

Asp?Asp?Leu?Trp?Leu?Asn?Glu?Ser?Phe?Ala?Thr?Trp?Ser?Ala?Ala?Ile

1 5 10 15

Ser?Gln?Ala?Glu?Glu?Thr?Glu?Tyr?Asn?Thr?Ala?Trp?Val?Thr?Phe?Ala

20 25 30

Asn?Val?Glu?Lys?Ser?Trp?Ala?Tyr?Gln?Gln?Asp?Gln?Leu?Pro?Ser?Thr

35 40 45

His?Pro?Val?Phe?Ser?Asp?Gly?Tyr?Asp?Ile?Glu?Thr?Val?Asp?Gln?Asn

50 55 60

Phe?Asp?Gly?Ile?Thr?Tyr?Ala?Lys?Gly?Ala?Ser?Val?Leu?Lys?Gln?Leu

65 70 75 80

Gln?Ala?Tyr?Val?Gly?Arg?Glu?Glu?Phe?Leu?Ala?Gly?Val?Arg?Arg?His

85 90 95

Phe?Ala?Asn?His?Ala?Trp?Gly?Asn?Ala?Ser?Phe?Asp?Asp?Leu?Leu?Gly

100 105 110

Ala?Leu?Glu?Gln?Ser?Ser?Gly?Arg?Asp?Leu?Ser?Asp?Trp?Ala?Asn?Gln

115 120 125

Trp?Leu?Lys?Thr?Thr?Gly?Ile?Asn?Thr?Leu?Gly?Ala?Lys?Phe?Thr?Thr

130 135 140

Asp?Asn?Gly?Lys?Tyr?Thr?Ser?Phe?Ser?Val?Thr?Gln?Thr?Gly?Ala?Ala

145 150 155 160

Pro?Gly?Ala?Gly?Glu?Leu?Arg?Thr?His?Arg?Ile?Ala?Val?Gly?Leu?Tyr

165 170 175

Lys?Leu?Val?Asp?Gly?Ser?Leu?Asn?Arg?Tyr?Ala?Arg?Val?Glu?Leu?Asp

180 185 190

Cys?Ser?Gly?Ala?Ser?Thr?Ser?Val?Glu?Glu?Ile?Val?Gly?Leu?Glu?Gln

195 200 205

Ala?Asp?Phe?Val?Leu?Val?Asn?Asp?Asp?Asp?Leu?Thr?Tyr?Ala?Leu?Leu

210 215 220

Asp?Leu?Asp?Asp?Asp?Ser?Arg?Asn?Phe?Val?Ile?Asp?Asn?Ile?Asp?Lys

225 230 235 240

Phe?Ser?Asp?Pro?Met?Pro?Arg?Thr?Leu?Val?Trp?Ser?Ala?Ala?Trp?Glu

245 250 255

Met?Thr?Arg?Ala?Gly?Gln?Met?Lys?Ala?Arg?Asp?Phe?Ile?Ala?Leu?Val

260 265 270

Ala?Arg?Gly?Ala?Ala?Ala?Glu?Thr?Glu?Ile?Ala?Val?Leu?Glu?Arg?Ile

275 280 285

Leu?Ala?Gln?Ala?Thr?Ser?Ala?Leu?Lys?Ser?Tyr?Ala?Asp?Pro?Ala?Trp

290 295 300

Ala?Glu?Ala?Thr?Gly?Asn?Asp?Leu?Leu?Ala?Asp?Ala?Phe?Leu?Glu?Gly

305 310 315 320

Ala?Arg?Ser?Ala?Glu?Pro?Asp?Ser?Asp?Thr?Gln?Leu?Ala?Phe?Ile?Gln

325 330 335

Ala?Leu?Ala?Lys?Ala?Thr?Leu?Asn?Asp?Ala?Ala?Ala?Asp?Tyr?Phe?Arg

340 345 350

Asp?Ile?Leu?Ala?Gly?Asn?Val?Glu?Gly?Leu?Thr?Val?Asp?Pro?Asp?Leu

355 360 365

Arg?Trp?Trp?Ala?Leu?Thr?Ala?Leu?Ile?Ala?Arg?Gly?Asp?Ile?Glu?Ala

370 375 380

Val?Glu?Asp?Ala?Ile?Ala?Ala?Glu?Leu?Ser?Arg?Asp?Asn?Ser?Ser?Ala

385 390 395 400

Ser?Phe?Leu?Ala?Ser?Leu?Arg?Ala?Gly?Ala?Ala?Val?Asn?Thr?Glu?Glu

405 410 415

Val?Lys?Ala?Ala?Ala?Tyr?Lys?His?Val?Pro?Ala?Val?Asp?Ser?Gly?Leu

420 425 430

Ser?Asn?Leu?Glu?Leu?Arg?His?Lys?Ile?Glu?Gly?Leu?Thr?Phe?Thr?Gly

435 440 445

Ser?Phe?Glu?Leu?Leu?Gln?Ala?Tyr?Asn?Glu?Gln?Tyr?Phe?Glu?Ile?Leu

450 455 460

Asp?Asp?Val?Trp?Ala?Asn?Phe?Ser?Gly?Glu?Met?Ala?Gln?Gln?Ile?Val

465 470 475 480

Leu?Gly?Leu?Phe?Pro?Ser?Trp?Asn?Val?Ser?Glu?Glu?Gly?Leu?Lys?Arg

485 490 495

Thr?Asp?Glu?Phe?Leu?Asp?Gly?Glu?His?Val?Ala?Gly?Ile?Lys?Arg?Ile

500 505 510

Val?Ser?Glu?Ser?Leu?Asp?Arg?Thr?Ala?Arg?Ala?Leu?Arg?Asn

515 520 525

<210>107

<211>964

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(964)

<223>FRXA01018

<400>107

tcttaaagtt?ttctagcaat?ccacactagg?cgcgaactat?cgtggtgtca?ttgcgcacct?60

tctaagggta?gcgccccctc?aaatttcaag?gagcattaaa?ttg?acg?tcc?act?aat 115

Leu?Thr?Ser?Thr?Asn

1 5

ctc?acc?cga?cag?gaa?gct?tcg?gat?cgt?tcg?agg?tta?ctg?agt?gta?gaa 163

Leu?Thr?Arg?Gln?Glu?Ala?Ser?Asp?Arg?Ser?Arg?Leu?Leu?Ser?Val?Glu

10 15 20

aac?tat?gac?att?gca?ctt?gat?ctc?aac?aac?ggt?gat?gag?ttt?ttt?agt 211

Asn?Tyr?Asp?Ile?Ala?Leu?Asp?Leu?Asn?Asn?Gly?Asp?Glu?Phe?Phe?Ser

25 30 35

tcc?tcc?acc?gtt?gtc?agc?ttc?act?gtc?agg?aag?gct?ggc?gat?acc?ttt 259

Ser?Ser?Thr?Val?Val?Ser?Phe?Thr?Val?Arg?Lys?Ala?Gly?Asp?Thr?Phe

40 45 50

att?gat?ctc?cgc?gca?gca?agc?gtt?gag?gag?gtt?cgc?ctg?gac?aat?gtg 307

Ile?Asp?Leu?Arg?Ala?Ala?Ser?Val?Glu?Glu?Val?Arg?Leu?Asp?Asn?Val

55 60 65

tcc?atc?aaa?gat?gag?gct?cta?acc?ctt?ggc?aag?aac?ggc?tac?gac?gag

Ser?Ile?Lys?Asp?Glu?Ala?Leu?Thr?Leu?Gly?Lys?Asn?Gly?Tyr?Asp?Glu

70 75 80 85

acg?ttc?ggc?atc?gcc?ctg?aag?ggt?ctt?act?ccc?ggc?gcg?cac?acc?ttg 403

Thr?Phe?Gly?Ile?Ala?Leu?Lys?Gly?Leu?Thr?Pro?Gly?Ala?His?Thr?Leu

90 95 100

cgg?gta?acg?gcg?tct?atc?ccc?tat?tcc?cgc?acc?ggt?gaa?ggc?ctg?cac 451

Arg?Val?Thr?Ala?Ser?Ile?Pro?Tyr?Ser?Arg?Thr?Gly?Glu?Gly?Leu?His

105 110 115

cgc?atg?gtg?gat?cca?gca?gac?aat?gag?gtg?tat?ttg?tac?acc?cag?ttt 499

Arg?Met?Val?Asp?Pro?Ala?Asp?Asn?Glu?Val?Tyr?Leu?Tyr?Thr?Gln?Phe

120 125 130

gag?acc?gcc?gat?gcc?aag?cgt?atg?ttc?gcg?tgt?ttc?gat?cag?cca?gac 547

Glu?Thr?Ala?Asp?Ala?Lys?Arg?Met?Phe?Ala?Cys?Phe?Asp?Gln?Pro?Asp

135 140 145

ctc?aag?gct?acc?tat?gat?ctg?aac?atc?aaa?act?cct?aag?ggt?tgg?aag 595

Leu?Lys?Ala?Thr?Tyr?Asp?Leu?Asn?Ile?Lys?Thr?Pro?Lys?Gly?Trp?Lys

150 155 160 165

atc?att?tcc?aac?tct?gag?cag?cag?gtt?tcc?act?cag?cac?act?gat?tac 643

Ile?Ile?Ser?Asn?Ser?Glu?Gln?Gln?Val?Ser?Thr?Gln?His?Thr?Asp?Tyr

170 175 180

gat?acc?cac?att?tcc?cga?gtg?gac?tat?ccc?ctc?tcc?acc?tac?ctg?att 691

Asp?Thr?His?Ile?Ser?Arg?Val?Asp?Tyr?Pro?Leu?Ser?Thr?Tyr?Leu?Ile

185 190 195

gcg?gtg?tgc?gcg?ggt?cgt?tac?cac?gag?gtg?tgc?gat?gtc?tgg?aag?ggt 739

Ala?Val?Cys?Ala?Gly?Arg?Tyr?His?Glu?Val?Cys?Asp?Val?Trp?Lys?Gly

200 205 210

acg?ctc?acc?cac?cat?gca?gaa?aca?cct?gcc?gat?cag?cca?act?gag?ctg 787

Thr?Leu?Thr?His?His?Ala?Glu?Thr?Pro?Ala?Asp?Gln?Pro?Thr?Glu?Leu

215 220 225

act?gtt?ccg?ctt?gct?ctc?tac?tgc?cgc?agt?tct?ttg?gct?aaa?gat?ctt 835

Thr?Val?Pro?Leu?Ala?Leu?Tyr?Cys?Arg?Ser?Ser?Leu?Ala?Lys?Asp?Leu

230 235 240 245

gat?gcg?gtg?cgt?ctg?ttt?acc?gaa?acg?aag?cag?ggc?ttt?gat?tgg?tac 883

Asp?Ala?Val?Arg?Leu?Phe?Thr?Glu?Thr?Lys?Gln?Gly?Phe?Asp?Trp?Tyr

250 255 260

cac?cgc?aac?ttc?ggt?gtg?gcg?tac?cca?ttc?ggc?aag?tac?gat?cag?atc 931

His?Arg?Asn?Phe?Gly?Val?Ala?Tyr?Pro?Phe?Gly?Lys?Tyr?Asp?Gln?Ile

265 270 275

ttc?gtc?cct?gaa?ttt?aat?gct?ggc?gcg?atg?gag 964

Phe?Val?Pro?Glu?Phe?Asn?Ala?Gly?Ala?Met?Glu

280 285

<210>108

<211>288

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>108

Leu?Thr?Ser?Thr?Asn?Leu?Thr?Arg?Gln?Glu?Ala?Ser?Asp?Arg?Ser?Arg

1 5 10 15

Leu?Leu?Ser?Val?Glu?Asn?Tyr?Asp?Ile?Ala?Leu?Asp?Leu?Asn?Asn?Gly

20 25 30

Asp?Glu?Phe?Phe?Ser?Ser?Ser?Thr?Val?Val?Ser?Phe?Thr?Val?Arg?Lys

35 40 45

Ala?Gly?Asp?Thr?Phe?Ile?Asp?Leu?Arg?Ala?Ala?Ser?Val?Glu?Glu?Val

50 55 60

Arg?Leu?Asp?Asn?Val?Ser?Ile?Lys?Asp?Glu?Ala?Leu?Thr?Leu?Gly?Lys

65 70 75 80

Asn?Gly?Tyr?Asp?Glu?Thr?Phe?Gly?Ile?Ala?Leu?Lys?Gly?Leu?Thr?Pro

85 90 95

Gly?Ala?His?Thr?Leu?Arg?Val?Thr?Ala?Ser?Ile?Pro?Tyr?Ser?Arg?Thr

100 105 110

Gly?Glu?Gly?Leu?His?Arg?Met?Val?Asp?Pro?Ala?Asp?Asn?Glu?Val?Tyr

115 120 125

Leu?Tyr?Thr?Gln?Phe?Glu?Thr?Ala?Asp?Ala?Lys?Arg?Met?Phe?Ala?Cys

130 135 140

Phe?Asp?Gln?Pro?Asp?Leu?Lys?Ala?Thr?Tyr?Asp?Leu?Asn?Ile?Lys?Thr

145 150 155 160

Pro?Lys?Gly?Trp?Lys?Ile?Ile?Ser?Asn?Ser?Glu?Gln?Gln?Val?Ser?Thr

165 170 175

Gln?His?Thr?Asp?Tyr?Asp?Thr?His?Ile?Ser?Arg?Val?Asp?Tyr?Pro?Leu

180 185 190

Ser?Thr?Tyr?Leu?Ile?Ala?Val?Cys?Ala?Gly?Arg?Tyr?His?Glu?Val?Cys

195 200 205

Asp?Val?Trp?Lys?Gly?Thr?Leu?Thr?His?His?Ala?Glu?Thr?Pro?Ala?Asp

210 215 220

Gln?Pro?Thr?Glu?Leu?Thr?Val?Pro?Leu?Ala?Leu?Tyr?Cys?Arg?Ser?Ser

225 230 235 240

Leu?Ala?Lys?Asp?Leu?Asp?Ala?Val?Arg?Leu?Phe?Thr?Glu?Thr?Lys?Gln

245 250 255

Gly?Phe?Asp?Trp?Tyr?His?Arg?Asn?Phe?Gly?Val?Ala?Tyr?Pro?Phe?Gly

260 265 270

Lys?Tyr?Asp?Gln?Ile?Phe?Val?Pro?Glu?Phe?Asn?Ala?Gly?Ala?Met?Glu

275 280 285

<210>109

<211>1383

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1360)

<223>RXA01147

<400>109

ataatgatca?cctactttaa?cggcttcagg?tgacattgtg?gattcgcatt?gtggattcgg?60

gggcccgcgc?tgtttccaag?aatttggcta?cccttgttct?atg?cat?gta?act?gac 115

Met?His?Val?Thr?Asp

1 5

gat?ttc?tta?agt?ttt?att?gcc?cta?agc?cca?agt?tcc?tat?cac?gcg?gcc 163

Asp?Phe?Leu?Ser?Phe?Ile?Ala?Leu?Ser?Pro?Ser?Ser?Tyr?His?Ala?Ala

10 15 20

gcg?gcg?gtg?gag?cgc?agg?ttg?ctc?cat?gag?ggg?ttc?att?cgt?cag?gaa 211

Ala?Ala?Val?Glu?Arg?Arg?Leu?Leu?His?Glu?Gly?Phe?Ile?Arg?Gln?Glu

25 30 35

gat?acc?gat?gaa?tgg?gat?gcc?cgc?cct?ggt?ggg?cat?gtg?acg?gtg?cgt 259

Asp?Thr?Asp?Glu?Trp?Asp?Ala?Arg?Pro?Gly?Gly?His?Val?Thr?Val?Arg

40 45 50

ggg?gga?gca?gta?gtg?gcg?tgg?tgg?gtg?cct?gag?gat?gct?tcg?cca?gat 307

Gly?Gly?Ala?Val?Val?Ala?Trp?Trp?Val?Pro?Glu?Asp?Ala?Ser?Pro?Asp

55 60 65

tcc?ggg?ttc?cgc?atc?att?ggg?tca?cat?act?gat?tca?ccg?ggt?ttc?aag 355

Ser?Gly?Phe?Arg?Ile?Ile?Gly?Ser?His?Thr?Asp?Ser?Pro?Gly?Phe?Lys

70 75 80 85

tta?aag?ccc?cgt?ggg?gat?ctt?tcc?tca?cac?ggt?tgg?cag?cag?gcc?ggc 403

Leu?Lys?Pro?Arg?Gly?Asp?Leu?Ser?Ser?His?Gly?Trp?Gln?Gln?Ala?Gly

90 95 100

gtc?gag?gtt?tac?ggc?gga?ccg?atc?ctg?cca?agc?tgg?ctg?gat?cgc?gag 451

Val?Glu?Val?Tyr?Gly?Gly?Pro?Ile?Leu?Pro?Ser?Trp?Leu?Asp?Arg?Glu

105 110 115

ctg?gcc?tta?gca?ggc?cgc?att?gtg?ctt?gcc?gac?ggg?tcc?gtc?aag?ctt 499

Leu?Ala?Leu?Ala?Gly?Arg?Ile?Val?Leu?Ala?Asp?Gly?Ser?Val?Lys?Leu

120 125 130

gtc?aac?acc?ggc?ccg?att?ctg?cgc?atc?ccg?cac?gtg?gct?att?cat?ttg 547

Val?Asn?Thr?Gly?Pro?Ile?Leu?Arg?Ile?Pro?His?Val?Ala?Ile?His?Leu

135 140 145

gac?cgt?act?gtt?aat?tcc?caa?ctc?acc?ctt?aat?cca?cag?cgt?cac?ctg 595

Asp?Arg?Thr?Val?Asn?Ser?Gln?Leu?Thr?Leu?Asn?Pro?Gln?Arg?His?Leu

150 155 160 165

cag?cct?gtg?ttt?gct?gtt?ggt?gag?ccc?gac?gta?tca?att?ctg?gat?gtc 643

Gln?Pro?Val?Phe?Ala?Val?Gly?Glu?Pro?Asp?Val?Ser?Ile?Leu?Asp?Val

170 175 180

att?gct?ggt?gct?gcg?gta?gtg?gat?cct?gca?gat?att?gtc?agc?cat?gat 691

Ile?Ala?Gly?Ala?Ala?Val?Val?Asp?Pro?Ala?Asp?Ile?Val?Ser?His?Asp

185 190 195

ctg?atc?acg?gtg?gct?acc?caa?gat?gct?gaa?gta?ttt?ggc?gca?cat?ggg 739

Leu?Ile?Thr?Val?Ala?Thr?Gln?Asp?Ala?Glu?Val?Phe?Gly?Ala?His?Gly

200 205 210

gat?ttc?ttg?gcg?tct?ggt?cgc?ctg?gat?aac?ctg?agc?agc?gtg?cat?cca 787

Asp?Phe?Leu?Ala?Ser?Gly?Arg?Leu?Asp?Asn?Leu?Ser?Ser?Val?His?Pro

215 220 225

tcc?atg?act?gca?ttg?att?gcg?gct?tcg?caa?tct?gac?gat?act?ggt?tcg 835

Ser?Met?Thr?Ala?Leu?Ile?Ala?Ala?Ser?Gln?Ser?Asp?Asp?Thr?Gly?Ser

230 235 240 245

gat?att?ttg?gtt?ctt?gct?gca?ttc?gat?cat?gaa?gaa?gtg?gga?agt?aat 883

Asp?Ile?Leu?Val?Leu?Ala?Ala?Phe?Asp?His?Glu?Glu?Val?Gly?Ser?Asn

250 255 260

tcc?acc?tcg?ggt?gcc?ggg?ggc?ccc?ctg?ttg?gag?gat?gtg?ctc?aac?cgt 931

Ser?Thr?Ser?Gly?Ala?Gly?Gly?Pro?Leu?Leu?Glu?Asp?Val?Leu?Asn?Arg

265 270 275

act?gct?cgt?gcg?ttg?ggt?gca?gat?gaa?gat?gag?cga?cgc?cgg?atg?ttt 979

Thr?Ala?Arg?Ala?Leu?Gly?Ala?Asp?Glu?Asp?Glu?Arg?Arg?Arg?Met?Phe

280 285 290

aac?cgt?tcc?acc?atg?gtc?tca?gct?gac?gcg?gca?cac?tcc?att?cac?ccc 1027

Asn?Arg?Ser?Thr?Met?Val?Ser?Ala?Asp?Ala?Ala?His?Ser?Ile?His?Pro

295 300 305

aac?ttc?ccc?gag?aag?cat?gat?caa?gct?aat?tac?ccc?atc?att?ggt?aaa 1075

Asn?Phe?Pro?Glu?Lys?His?Asp?Gln?Ala?Asn?Tyr?Pro?Ile?Ile?Gly?Lys

310 315 320 325

ggt?cct?gta?ttg?aag?gtc?aac?gcc?aac?cag?cgc?tac?acc?tcc?gat?gca 1123

Gly?Pro?Val?Leu?Lys?Val?Asn?Ala?Asn?Gln?Arg?Tyr?Thr?Ser?Asp?Ala

330 335 340

gtc?act?tca?ggc?atg?tgg?atc?agg?gca?tgt?cag?att?gcc?ggt?gtg?cca 1171

Val?Thr?Ser?Gly?Met?Trp?Ile?Arg?Ala?Cys?Gln?Ile?Ala?Gly?Val?Pro

345 350 355

cac?cag?gtg?ttt?gcc?ggc?aac?aac?gat?gtg?ccg?tgt?ggt?tcc?acc?atc 1219

His?Gln?Val?Phe?Ala?Gly?Asn?Asn?Asp?Val?Pro?Cys?Gly?Ser?Thr?Ile

360 365 370

ggc?ccg?atc?agt?gcg?act?cgc?ctg?ggt?atc?gat?tct?gtc?gat?gtc?ggt 1267

Gly?Pro?Ile?Ser?Ala?Thr?Arg?Leu?Gly?Ile?Asp?Ser?Val?Asp?Val?Gly

375 380 385

att?cca?ttg?ctg?tcc?atg?cac?tcc?gca?cgc?gaa?atg?gcc?gga?gtg?aag 1315

Ile?Pro?Leu?Leu?Ser?Met?His?Ser?Ala?Arg?Glu?Met?Ala?Gly?Val?Lys

390 395 400 405

gat?ctg?atg?tgg?ttt?gaa?caa?gcc?ctg?gaa?gcc?tat?ctg?gta?aat 1360

Asp?Leu?Met?Trp?Phe?Glu?Gln?Ala?Leu?Glu?Ala?Tyr?Leu?Val?Asn

410 415 420

taacgccgag?ttcaatcaag?aca 1383

<210>110

<211>420

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>110

Met?His?Val?Thr?Asp?Asp?Phe?Leu?Ser?Phe?Ile?Ala?Leu?Ser?Pro?Ser

1 5 10 15

Ser?Tyr?His?Ala?Ala?Ala?Ala?Val?Glu?Arg?Arg?Leu?Leu?His?Glu?Gly

20 25 30

Phe?Ile?Arg?Gln?Glu?Asp?Thr?Asp?Glu?Trp?Asp?Ala?Arg?Pro?Gly?Gly

35 40 45

His?Val?Thr?Val?Arg?Gly?Gly?Ala?Val?Val?Ala?Trp?Trp?Val?Pro?Glu

50 55 60

Asp?Ala?Ser?Pro?Asp?Ser?Gly?Phe?Arg?Ile?Ile?Gly?Ser?His?Thr?Asp

65 70 75 80

Ser?Pro?Gly?Phe?Lys?Leu?Lys?Pro?Arg?Gly?Asp?Leu?Ser?Ser?His?Gly

85 90 95

Trp?Gln?Gln?Ala?Gly?Val?Glu?Val?Tyr?Gly?Gly?Pro?Ile?Leu?Pro?Ser

100 105 110

Trp?Leu?Asp?Arg?Glu?Leu?Ala?Leu?Ala?Gly?Arg?Ile?Val?Leu?Ala?Asp

115 120 125

Gly?Ser?Val?Lys?Leu?Val?Asn?Thr?Gly?Pro?Ile?Leu?Arg?Ile?Pro?His

130 135 140

Val?Ala?Ile?His?Leu?Asp?Arg?Thr?Val?Asn?Ser?Gln?Leu?Thr?Leu?Asn

145 150 155 160

Pro?Gln?Arg?His?Leu?Gln?Pro?Val?Phe?Ala?Val?Gly?Glu?Pro?Asp?Val

165 170 175

Ser?Ile?Leu?Asp?Val?Ile?Ala?Gly?Ala?Ala?Val?Val?Asp?Pro?Ala?Asp

180 185 190

Ile?Val?Ser?His?Asp?Leu?Ile?Thr?Val?Ala?Thr?Gln?Asp?Ala?Glu?Val

195 200 205

Phe?Gly?Ala?His?Gly?Asp?Phe?Leu?Ala?Ser?Gly?Arg?Leu?Asp?Asn?Leu

210 215 220

Ser?Ser?Val?His?Pro?Ser?Met?Thr?Ala?Leu?Ile?Ala?Ala?Ser?Gln?Ser

225 230 235 240

Asp?Asp?Thr?Gly?Ser?Asp?Ile?Leu?Val?Leu?Ala?Ala?Phe?Asp?His?Glu

245 250 255

Glu?Val?Gly?Ser?Asn?Ser?Thr?Ser?Gly?Ala?Gly?Gly?Pro?Leu?Leu?Glu

260 265 270

Asp?Val?Leu?Asn?Arg?Thr?Ala?Arg?Ala?Leu?Gly?Ala?Asp?Glu?Asp?Glu

275 280 285

Arg?Arg?Arg?Met?Phe?Asn?Arg?Ser?Thr?Met?Val?Ser?Ala?Asp?Ala?Ala

290 295 300

His?Ser?Ile?His?Pro?Asn?Phe?Pro?Glu?Lys?His?Asp?Gln?Ala?Asn?Tyr

305 310 315 320

Pro?Ile?Ile?Gly?Lys?Gly?Pro?Val?Leu?Lys?Val?Asn?Ala?Asn?Gln?Arg

325 330 335

Tyr?Thr?Ser?Asp?Ala?Val?Thr?Ser?Gly?Met?Trp?Ile?Arg?Ala?Cys?Gln

340 345 350

Ile?Ala?Gly?Val?Pro?His?Gln?Val?Phe?Ala?Gly?Asn?Asn?Asp?Val?Pro

355 360 365

Cys?Gly?Ser?Thr?Ile?Gly?Pro?Ile?Ser?Ala?Thr?Arg?Leu?Gly?Ile?Asp

370 375 380

Ser?Val?Asp?Val?Gly?Ile?Pro?Leu?Leu?Ser?Met?His?Ser?Ala?Arg?Glu

385 390 395 400

Met?Ala?Gly?Val?Lys?Asp?Leu?Met?Trp?Phe?Glu?Gln?Ala?Leu?Glu?Ala

405 410 415

Tyr?Leu?Val?Asn

420

<210>111

<211>1260

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1237)

<223>RXA0116l

<400>111

tttttcgtga?tcaacaatcc?gctggcatag?cgtccagcag?atttgattct?gacagtgtgg?60

tttgatcgca?cacctgccta?ggctactagg?gttggagact?atg?agt?gat?cct?tca 115

Met?Ser?Asp?Pro?Ser

1 5

aca?aac?aat?ttc?ccc?aca?tcg?gta?tat?gca?cag?cgt?ctt?gcg?gat?gca 163

Thr?Asn?Asn?Phe?Pro?Thr?Ser?Val?Tyr?Ala?Gln?Arg?Leu?Ala?Asp?Ala

10 15 20

caa?gaa?ggc?gca?cgc?aag?gct?ggc?ttg?aac?ggt?ttg?atc?atc?ggt?aca 211

Gln?Glu?Gly?Ala?Arg?Lys?Ala?Gly?Leu?Asn?Gly?Leu?Ile?Ile?Gly?Thr

25 30 35

ggc?gca?gaa?ctt?gcg?tat?cta?acc?ggc?agc?tgg?atc?tcc?acc?cat?gag 259

Gly?Ala?Glu?Leu?Ala?Tyr?Leu?Thr?Gly?Ser?Trp?Ile?Ser?Thr?His?Glu

40 45 50

cgt?cta?acc?gct?ttg?gtg?atc?ccc?agc?gaa?gga?acc?gca?acc?att?gtt 307

Arg?Leu?Thr?Ala?Leu?Val?Ile?Pro?Ser?Glu?Gly?Thr?Ala?Thr?Ile?Val

55 60 65

ctt?ccc?gct?gta?gac?cgc?gga?gac?tta?gca?ctg?tct?gct?att?cca?gga 355

Leu?Pro?Ala?Val?Asp?Arg?Gly?Asp?Leu?Ala?Leu?Ser?Ala?Ile?Pro?Gly

70 75 80 85

cta?gac?atc?aat?gtg?gcc?gga?tgg?gtt?gat?ggc?gat?aat?gcc?cat?gag 403

Leu?Asp?Ile?Asn?Val?Ala?Gly?Trp?Val?Asp?Gly?Asp?Asn?Ala?His?Glu

90 95 100

ttg?gcc?gta?gat?gct?ctc?ggt?gtt?tca?gag?ttc?gaa?gca?ttg?ggt?att 451

Leu?Ala?Val?Asp?Ala?Leu?Gly?Val?Ser?Glu?Phe?Glu?Ala?Leu?Gly?Ile

105 110 115

ggt?tcc?tcc?atc?acg?gca?gat?cac?ctg?att?cct?atc?cag?aac?ctg?gtg 499

Gly?Ser?Ser?Ile?Thr?Ala?Asp?His?Leu?Ile?Pro?Ile?Gln?Asn?Leu?Val

120 125 130

ggc?tcc?acc?tgc?cgc?atg?gag?ttg?gca?gtt?caa?gtg?ctg?aaa?gaa?ttg 547

Gly?Ser?Thr?Cys?Arg?Met?Glu?Leu?Ala?Val?Gln?Val?Leu?Lys?Glu?Leu

135 140 145

ttt?gtc?tct?aaa?gac?gaa?gca?gag?atc?gag?cag?ctt?cgc?ggc?gca?ggt 595

Phe?Val?Ser?Lys?Asp?Glu?Ala?Glu?Ile?Glu?Gln?Leu?Arg?Gly?Ala?Gly

150 155 160 165

gca?gcc?att?gac?cgt?gtc?cac?gcc?aaa?gtc?ccg?gag?ctt?ctt?caa?gac 643

Ala?Ala?Ile?Asp?Arg?Val?His?Ala?Lys?Val?Pro?Glu?Leu?Leu?Gln?Asp

170 175 180

gga?cgc?acc?gaa?gca?gag?gtt?gca?gca?cag?ctc?aac?gat?ctc?atc?ttg 691

Gly?Arg?Thr?Glu?Ala?Glu?Val?Ala?Ala?Gln?Leu?Asn?Asp?Leu?Ile?Leu

185 190 195

gaa?gag?cac?tct?gag?gtg?gac?ttc?gtg?att?gtg?gga?tcc?gct?gaa?aac 739

Glu?Glu?His?Ser?Glu?Val?Asp?Phe?Val?Ile?Val?Gly?Ser?Ala?Glu?Asn

200 205 210

ggc?gcg?aac?cct?cac?cac?ggt?ttc?tct?gac?cga?gtc?ctc?cgc?aat?ggc 787

Gly?Ala?Asn?Pro?His?His?Gly?Phe?Ser?Asp?Arg?Val?Leu?Arg?Asn?Gly

215 220 225

gac?atc?gtg?gtg?gtt?gat?ata?gga?ggc?acc?ttc?ggc?cct?ggt?tac?cac 835

Asp?Ile?Val?Val?Val?Asp?Ile?Gly?Gly?Thr?Phe?Gly?Pro?Gly?Tyr?His

230 235 240 245

tct?gac?tgc?aca?cgc?acc?tac?att?gtg?ggc?gga?aac?cct?gac?gat?gcg 883

Ser?Asp?Cys?Thr?Arg?Thr?Tyr?Ile?Val?Gly?Gly?Asn?Pro?Asp?Asp?Ala

250 255 260

gat?cca?gag?ttc?gct?aag?ttc?tac?caa?gtg?ctc?tac?gaa?gca?cag?ctc 931

Asp?Pro?Glu?Phe?Ala?Lys?Phe?Tyr?Gln?Val?Leu?Tyr?Glu?Ala?Gln?Leu

265 270 275

gca?gcc?gtt?gcg?cat?gtt?cgc?cct?ggc?gtt?act?gca?gaa?tca?gtg?gac 979

Ala?Ala?Val?Ala?His?Val?Arg?Pro?Gly?Val?Thr?Ala?Glu?Ser?Val?Asp

280 285 290

gct?gtt?gct?cgc?gat?cac?att?gct?gcg?gct?gga?tac?ggc?gaa?tac?ttc 1027

Ala?Val?Ala?Arg?Asp?His?Ile?Ala?Ala?Ala?Gly?Tyr?Gly?Glu?Tyr?Phe

295 300 305

att?cac?cgc?aca?gga?cac?ggc?att?ggt?cta?tcc?acc?cat?gag?gag?cca 1075

Ile?His?Arg?Thr?Gly?His?Gly?Ile?Gly?Leu?Ser?Thr?His?Glu?Glu?Pro

310 315 320 325

ttc?atc?atg?gcg?ggt?aac?tca?ctc?gtg?ttg?gaa?gcc?gga?atg?gcc?ttt 1123

Phe?Ile?Met?Ala?Gly?Asn?Ser?Leu?Val?Leu?Glu?Ala?Gly?Met?Ala?Phe

330 335 340

tcc?att?gag?cct?ggc?atc?tac?att?gaa?gga?atc?cac?gga?gcg?cgc?atc 1171

Ser?Ile?Glu?Pro?Gly?Ile?Tyr?Ile?Glu?Gly?Ile?His?Gly?Ala?Arg?Ile

345 350 355

gaa?gac?atc?gtt?gtg?gtg?aat?gaa?gac?ggt?tgt?gaa?acc?ctc?aac?aac 1219

Glu?Asp?Ile?Val?Val?Val?Asn?Glu?Asp?Gly?Cys?Glu?Thr?Leu?Asn?Asn

360 365 370

cag?ccc?aag?gaa?ctg?cgt?tgagcattct?tctcctaggc?gga 1260

Gln?Pro?Lys?Glu?Leu?Arg

375

<210>112

<211>379

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>112

Met?Ser?Asp?Pro?Ser?Thr?Asn?Asn?Phe?Pro?Thr?Ser?Val?Tyr?Ala?Gln

1 5 10 15

Arg?Leu?Ala?Asp?Ala?Gln?Glu?Gly?Ala?Arg?Lys?Ala?Gly?Leu?Asn?Gly

20 25 30

Leu?Ile?Ile?Gly?Thr?Gly?Ala?Glu?Leu?Ala?Tyr?Leu?Thr?Gly?Ser?Trp

35 40 45

Ile?Ser?Thr?His?Glu?Arg?Leu?Thr?Ala?Leu?Val?Ile?Pro?Ser?Glu?Gly

50 55 60

Thr?Ala?Thr?Ile?Val?Leu?Pro?Ala?Val?Asp?Arg?Gly?Asp?Leu?Ala?Leu

65 70 75 80

Ser?Ala?Ile?Pro?Gly?Leu?Asp?Ile?Asn?Val?Ala?Gly?Trp?Val?Asp?Gly

85 90 95

Asp?Asn?Ala?His?Glu?Leu?Ala?Val?Asp?Ala?Leu?Gly?Val?Ser?Glu?Phe

100 105 110

Glu?Ala?Leu?Gly?Ile?Gly?Ser?Ser?Ile?Thr?Ala?Asp?His?Leu?Ile?Pro

115 120 125

Ile?Gln?Asn?Leu?Val?Gly?Ser?Thr?Cys?Arg?Met?Glu?Leu?Ala?Val?Gln

130 135 140

Val?Leu?Lys?Glu?Leu?Phe?Val?Ser?Lys?Asp?Glu?Ala?Glu?Ile?Glu?Gln

145 150 155 160

Leu?Arg?Gly?Ala?Gly?Ala?Ala?Ile?Asp?Arg?Val?His?Ala?Lys?Val?Pro

165 170 175

Glu?Leu?Leu?Gln?Asp?Gly?Arg?Thr?Glu?Ala?Glu?Val?Ala?Ala?Gln?Leu

180 185 190

Asn?Asp?Leu?Ile?Leu?Glu?Glu?His?Ser?Glu?Val?Asp?Phe?Val?Ile?Val

195 200 205

Gly?Ser?Ala?Glu?Asn?Gly?Ala?Asn?Pro?His?His?Gly?Phe?Ser?Asp?Arg

210 215 220

Val?Leu?Arg?Asn?Gly?Asp?Ile?Val?Val?Val?Asp?Ile?Gly?Gly?Thr?Phe

225 230 235 240

Gly?Pro?Gly?Tyr?His?Ser?Asp?Cys?Thr?Arg?Thr?Tyr?Ile?Val?Gly?Gly

245 250 255

Asn?Pro?Asp?Asp?Ala?Asp?Pro?Glu?Phe?Ala?Lys?Phe?Tyr?Gln?Val?Leu

260 265 270

Tyr?Glu?Ala?Gln?Leu?Ala?Ala?Val?Ala?His?Val?Arg?Pro?Gly?Val?Thr

275 280 285

Ala?Glu?Ser?Val?Asp?Ala?Val?Ala?Arg?Asp?His?Ile?Ala?Ala?Ala?Gly

290 295 300

Tyr?Gly?Glu?Tyr?Phe?Ile?His?Arg?Thr?Gly?His?Gly?Ile?Gly?Leu?Ser

305 310 315 320

Thr?His?Glu?Glu?Pro?Phe?Ile?Met?Ala?Gly?Asn?Ser?Leu?Val?Leu?Glu

325 330 335

Ala?Gly?Met?Ala?Phe?Ser?Ile?Glu?Pro?Gly?Ile?Tyr?Ile?Glu?Gly?Ile

340 345 350

His?Gly?Ala?Arg?Ile?Glu?Asp?Ile?Val?Val?Val?Asn?Glu?Asp?Gly?Cys

355 360 365

Glu?Thr?Leu?Asn?Asn?Gln?Pro?Lys?Glu?Leu?Arg

370 375

<210>113

<211>980

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(957)

<223>RXN01181

<400>113

tct?gta?ctg?ctc?gct?cgc?gac?ttg?gtg?aac?acc?cct?tca?tca?cac?ctg 48

Ser?Val?Leu?Leu?Ala?Arg?Asp?Leu?Val?Asn?Thr?Pro?Ser?Ser?His?Leu

1 5 10 15

tac?cca?gag?tcc?tac?tca?gta?att?gca?tcc?aac?gaa?gcg?tcc?aag?cac 96

Tyr?Pro?Glu?Ser?Tyr?Ser?Val?Ile?Ala?Ser?Asn?Glu?Ala?Ser?Lys?His

20 25 30

ggc?ttg?cag?acc?acc?atc?ctg?gat?gag?aag?cag?ctt?gct?gat?caa?ggt 144

Gly?Leu?Gln?Thr?Thr?Ile?Leu?Asp?Glu?Lys?Gln?Leu?Ala?Asp?Gln?Gly

35 40 45

ttc?ggc?ggc?atc?ctc?gca?gtc?ggt?aac?ggc?tcc?tcc?cgc?aag?cct?cgt 192

Phe?Gly?Gly?Ile?Leu?Ala?Val?Gly?Asn?Gly?Ser?Ser?Arg?Lys?Pro?Arg

50 55 60

ctg?ctg?cgc?atc?gat?tgg?aag?cca?cgc?aag?gct?aag?aag?tcg?atc?gct 240

Leu?Leu?Arg?Ile?Asp?Trp?Lys?Pro?Arg?Lys?Ala?Lys?Lys?Ser?Ile?Ala

65 70 75 80

ttg?gtt?ggc?aag?ggc?atc?acc?ttt?gac?acc?ggc?gga?att?tcc?atc?aag 288

Leu?Val?Gly?Lys?Gly?Ile?Thr?Phe?Asp?Thr?Gly?Gly?Ile?Ser?Ile?Lys

85 90 95

cct?ggc?gca?agc?atg?gag?aac?atg?atc?tcc?gac?atg?ggt?gga?tcc?gca 336

Pro?Gly?Ala?Ser?Met?Glu?Asn?Met?Ile?Ser?Asp?Met?Gly?Gly?Ser?Ala

100 105 110

tcc?gta?ttg?gcc?acc?att?atc?gct?gca?gct?cgt?ttg?aac?ctg?tcg?atc 384

Ser?Val?Leu?Ala?Thr?Ile?Ile?Ala?Ala?Ala?Arg?Leu?Asn?Leu?Ser?Ile

115 120 125

aac?gtc?ttc?gcg?ttc?cta?cca?atg?gct?gag?aac?atg?cca?tcc?ggt?gac 432

Asn?Val?Phe?Ala?Phe?Leu?Pro?Met?Ala?Glu?Asn?Met?Pro?Ser?Gly?Asp

130 135 140

gct?ttc?cgc?ccc?ggc?gat?gtc?atc?act?cat?ttc?ggt?ggt?atc?acc?tcc 480

Ala?Phe?Arg?Pro?Gly?Asp?Val?Ile?Thr?His?Phe?Gly?Gly?Ile?Thr?Ser

145 150 155 160

gaa?atc?ttg?aac?acc?gac?gct?gaa?ggc?cgc?ctc?att?ctg?gca?gat?gcc 528

Glu?Ile?Leu?Asn?Thr?Asp?Ala?Glu?Gly?Arg?Leu?Ile?Leu?Ala?Asp?Ala

165 170 175

att?gct?tac?gct?tct?gaa?gat?aag?cct?gac?tac?ctc?att?gat?gcg?gca 576

Ile?Ala?Tyr?Ala?Ser?Glu?Asp?Lys?Pro?Asp?Tyr?Leu?Ile?Asp?Ala?Ala

180 185 190

acc?ctg?act?ggt?gct?caa?tta?gtc?gct?tta?ggc?ctg?cgg?act?tca?ggt 624

Thr?Leu?Thr?Gly?Ala?Gln?Leu?Val?Ala?Leu?Gly?Leu?Arg?Thr?Ser?Gly

195 200 205

gtc?atg?ggt?acc?gat?gag?ttc?cgc?gac?agc?gtt?gcc?aag?act?ggc?cgc 672

Val?Met?Gly?Thr?Asp?Glu?Phe?Arg?Asp?Ser?Val?Ala?Lys?Thr?Gly?Arg

210 215 220

gag?gtt?ggc?gag?caa?gca?tgg?gca?atg?cct?ctt?cct?gaa?gag?ctc?gat 720

Glu?Val?Gly?Glu?Gln?Ala?Trp?Ala?Met?Pro?Leu?Pro?Glu?Glu?Leu?Asp

225 230 235 240

gag?cag?gtt?aag?tcc?cct?gtc?gct?gac?ctg?cgc?aat?gtc?acc?aat?tcc 768

Glu?Gln?Val?Lys?Ser?Pro?Val?Ala?Asp?Leu?Arg?Asn?Val?Thr?Asn?Ser

245 250 255

cgt?ttc?gca?gga?atg?tct?gct?gcg?ggt?cgt?tac?ttg?cag?gaa?ttc?gtt 816

Arg?Phe?Ala?Gly?Met?Ser?Ala?Ala?Gly?Arg?Tyr?Leu?Gln?Glu?Phe?Val

260 265 270

ggt?gcc?gac?atc?gag?tgg?gct?cac?gtc?gat?atc?gct?ggc?cct?gca?tac 864

Gly?Ala?Asp?Ile?Glu?Trp?Ala?His?Val?Asp?Ile?Ala?Gly?Pro?Ala?Tyr

275 280 285

aac?act?gct?ggt?gaa?ttc?ggt?tac?acg?cca?aag?cgc?gca?acc?gga?caa 912

Asn?Thr?Ala?Gly?Glu?Phe?Gly?Tyr?Thr?Pro?Lys?Arg?Ala?Thr?Gly?Gln

290 295 300

cca?gtg?cgc?acc?ttc?gtt?cag?gtt?ctg?aag?gat?ctg?tcg?gaa?agc 957

Pro?Val?Arg?Thr?Phe?Val?Gln?Val?Leu?Lys?Asp?Leu?Ser?Glu?Ser

305 310 315

taaacgctag?ttaaagatca?gga 980

<210>114

<211>319

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>114

Ser?Val?Leu?Leu?Ala?Arg?Asp?Leu?Val?Asn?Thr?Pro?Ser?Ser?His?Leu

1 5 10 15

Tyr?Pro?Glu?Ser?Tyr?Ser?Val?Ile?Ala?Ser?Asn?Glu?Ala?Ser?Lys?His

20 25 30

Gly?Leu?Gln?Thr?Thr?Ile?Leu?Asp?Glu?Lys?Gln?Leu?Ala?Asp?Gln?Gly

35 40 45

Phe?Gly?Gly?Ile?Leu?Ala?Val?Gly?Asn?Gly?Ser?Ser?Arg?Lys?Pro?Arg

50 55 60

Leu?Leu?Arg?Ile?Asp?Trp?Lys?Pro?Arg?Lys?Ala?Lys?Lys?Ser?Ile?Ala

65 70 75 80

Leu?Val?Gly?Lys?Gly?Ile?Thr?Phe?Asp?Thr?Gly?Gly?Ile?Ser?Ile?Lys

85 90 95

Pro?Gly?Ala?Ser?Met?Glu?Asn?Met?Ile?Ser?Asp?Met?Gly?Gly?Ser?Ala

100 105 110

Ser?Val?Leu?Ala?Thr?Ile?Ile?Ala?Ala?Ala?Arg?Leu?Asn?Leu?Ser?Ile

115 120 125

Asn?Val?Phe?Ala?Phe?Leu?Pro?Met?Ala?Glu?Asn?Met?Pro?Ser?Gly?Asp

130 135 140

Ala?Phe?Arg?Pro?Gly?Asp?Val?Ile?Thr?His?Phe?Gly?Gly?Ile?Thr?Ser

145 150 155 160

Glu?Ile?Leu?Asn?Thr?Asp?Ala?Glu?Gly?Arg?Leu?Ile?Leu?Ala?Asp?Ala

165 170 175

Ile?Ala?Tyr?Ala?Ser?Glu?Asp?Lys?Pro?Asp?Tyr?Leu?Ile?Asp?Ala?Ala

180 185 190

Thr?Leu?Thr?Gly?Ala?Gln?Leu?Val?Ala?Leu?Gly?Leu?Arg?Thr?Ser?Gly

195 200 205

Val?Met?Gly?Thr?Asp?Glu?Phe?Arg?Asp?Ser?Val?Ala?Lys?Thr?Gly?Arg

210 215 220

Glu?Val?Gly?Glu?Gln?Ala?Trp?Ala?Met?Pro?Leu?Pro?Glu?Glu?Leu?Asp

225 230 235 240

Glu?Gln?Val?Lys?Ser?Pro?Val?Ala?Asp?Leu?Arg?Asn?Val?Thr?Asn?Ser

245 250 255

Arg?Phe?Ala?Gly?Met?Ser?Ala?Ala?Gly?Arg?Tyr?Leu?Gln?Glu?Phe?Val

260 265 270

Gly?Ala?Asp?Ile?Glu?Trp?Ala?His?Val?Asp?Ile?Ala?Gly?Pro?Ala?Tyr

275 280 285

Asn?Thr?Ala?Gly?Glu?Phe?Gly?Tyr?Thr?Pro?Lys?Arg?Ala?Thr?Gly?Gln

290 295 300

Pro?Val?Arg?Thr?Phe?Val?Gln?Val?Leu?Lys?Asp?Leu?Ser?Glu?Ser

305 310 315

<210>115

<211>980

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(957)

<223>FRXA01181

<400>115

tct?gta?ctg?ctc?gct?cgc?gac?ttg?gtg?aac?acc?cct?tca?tca?cac?ctg 48

Ser?Val?Leu?Leu?Ala?Arg?Asp?Leu?Val?Asn?Thr?Pro?Ser?Ser?His?Leu

1 5 10 15

tac?cca?gag?tcc?tac?tca?gta?att?gca?tcc?aac?gaa?gcg?tcc?aag?cac 96

Tyr?Pro?Glu?Ser?Tyr?Ser?Val?Ile?Ala?Ser?Asn?Glu?Ala?Ser?Lys?His

20 25 30

ggc?ttg?cag?acc?acc?atc?ctg?gat?gag?aag?cag?ctt?gct?gat?caa?ggt 144

Gly?Leu?Gln?Thr?Thr?Ile?Leu?Asp?Glu?Lys?Gln?Leu?Ala?Asp?Gln?Gly

35 40 45

ttc?ggc?ggc?atc?ctc?gca?gtc?ggt?aac?ggc?tcc?tcc?cgc?aag?cct?cgt 192

Phe?Gly?Gly?Ile?Leu?Ala?Val?Gly?Asn?Gly?Ser?Ser?Arg?Lys?Pro?Arg

50 55 60

ctg?ctg?cgc?atc?gat?tgg?aag?cca?cgc?aag?gct?aag?aag?tcg?atc?gct 240

Leu?Leu?Arg?Ile?Asp?Trp?Lys?Pro?Arg?Lys?Ala?Lys?Lys?Ser?Ile?Ala

65 70 75 80

ttg?gtt?ggc?aag?ggc?atc?acc?ttt?gac?acc?ggc?gga?att?tcc?atc?aag 288

Leu?Val?Gly?Lys?Gly?Ile?Thr?Phe?Asp?Thr?Gly?Gly?Ile?Ser?Ile?Lys

85 90 95

cct?ggc?gca?agc?atg?gag?aac?atg?atc?tcc?gac?atg?ggt?gga?tcc?gca 336

Pro?Gly?Ala?Ser?Met?Glu?Asn?Met?Ile?Ser?Asp?Met?Gly?Gly?Ser?Ala

100 105 110

tcc?gta?ttg?gcc?acc?att?atc?gct?gca?gct?cgt?ttg?aac?ctg?tcg?atc 384

Ser?Val?Leu?Ala?Thr?Ile?Ile?Ala?Ala?Ala?Arg?Leu?Asn?Leu?Ser?Ile

115 120 125

aac?gtc?ttc?gcg?ttc?cta?cca?atg?gct?gag?aac?atg?cca?tcc?ggt?gac 432

Asn?Val?Phe?Ala?Phe?Leu?Pro?Met?Ala?Glu?Asn?Met?Pro?Ser?Gly?Asp

130 135 140

gct?ttc?cgc?ccc?ggc?gat?gtc?atc?act?cat?ttc?ggt?ggt?atc?acc?tcc 480

Ala?Phe?Arg?Pro?Gly?Asp?Val?Ile?Thr?His?Phe?Gly?Gly?Ile?Thr?Ser

145 150 155 160

gaa?atc?ttg?aac?acc?gac?gct?gaa?ggc?cgc?ctc?att?ctg?gca?gat?gcc 528

Glu?Ile?Leu?Asn?Thr?Asp?Ala?Glu?Gly?Arg?Leu?Ile?Leu?Ala?Asp?Ala

165 170 175

att?gct?tac?gct?tct?gaa?gat?aag?cct?gac?tac?ctc?att?gat?gcg?gca 576

Ile?Ala?Tyr?Ala?Ser?Glu?Asp?Lys?Pro?Asp?Tyr?Leu?Ile?Asp?Ala?Ala

180 185 190

acc?ctg?act?ggt?gct?caa?tta?gtc?gct?tta?ggc?ctg?cgg?act?tca?ggt 624

Thr?Leu?Thr?Gly?Ala?Gln?Leu?Val?Ala?Leu?Gly?Leu?Arg?Thr?Ser?Gly

195 200 205

gtc?atg?ggt?acc?gat?gag?ttc?cgc?gac?agc?gtt?gcc?aag?act?ggc?cgc 672

Val?Met?Gly?Thr?Asp?Glu?Phe?Arg?Asp?Ser?Val?Ala?Lys?Thr?Gly?Arg

210 215 220

gag?gtt?ggc?gag?caa?gca?tgg?gca?atg?cct?ctt?cct?gaa?gag?ctc?gat 720

Glu?Val?Gly?Glu?Gln?Ala?Trp?Ala?Met?Pro?Leu?Pro?Glu?Glu?Leu?Asp

225 230 235 240

gag?cag?gtt?aag?tcc?cct?gtc?gct?gac?ctg?cgc?aat?gtc?acc?aat?tcc 768

Glu?Gln?Val?Lys?Ser?Pro?Val?Ala?Asp?Leu?Arg?Asn?Val?Thr?Asn?Ser

245 250 255

cgt?ttc?gca?gga?atg?tct?gct?gcg?ggt?cgt?tac?ttg?cag?gaa?ttc?gtt 816

Arg?Phe?Ala?Gly?Met?Ser?Ala?Ala?Gly?Arg?Tyr?Leu?Gln?Glu?Phe?Val

260 265 270

ggt?gcc?gac?atc?gag?tgg?gct?cac?gtc?gat?atc?gct?ggc?cct?gca?tac 864

Gly?Ala?Asp?Ile?Glu?Trp?Ala?His?Val?Asp?Ile?Ala?Gly?Pro?Ala?Tyr

275 280 285

aac?act?gct?ggt?gaa?ttc?ggt?tac?acg?cca?aag?cgc?gca?acc?gga?caa 912

Asn?Thr?Ala?Gly?Glu?Phe?Gly?Tyr?Thr?Pro?Lys?Arg?Ala?Thr?Gly?Gln

290 295 300

cca?gtg?cgc?acc?ttc?gtt?cag?gtt?ctg?aag?gat?ctg?tcg?gaa?agc 957

Pro?Val?Arg?Thr?Phe?Val?Gln?Val?Leu?Lys?Asp?Leu?Ser?Glu?Ser

305 310 315

taaacgctag?ttaaagatca?gga 980

<210>116

<211>319

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>116

Ser?Val?Leu?Leu?Ala?Arg?Asp?Leu?Val?Asn?Thr?Pro?Ser?Ser?His?Leu

1 5 10 15

Tyr?Pro?Glu?Ser?Tyr?Ser?Val?Ile?Ala?Ser?Asn?Glu?Ala?Ser?Lys?His

20 25 30

Gly?Leu?Gln?Thr?Thr?Ile?Leu?Asp?Glu?Lys?Gln?Leu?Ala?Asp?Gln?Gly

35 40 45

Phe?Gly?Gly?Ile?Leu?Ala?Val?Gly?Asn?Gly?Ser?Ser?Arg?Lys?Pro?Arg

50 55 60

Leu?Leu?Arg?Ile?Asp?Trp?Lys?Pro?Arg?Lys?Ala?Lys?Lys?Ser?Ile?Ala

65 70 75 80

Leu?Val?Gly?Lys?Gly?Ile?Thr?Phe?Asp?Thr?Gly?Gly?Ile?Ser?Ile?Lys

85 90 95

Pro?Gly?Ala?Ser?Met?Glu?Asn?Met?Ile?Ser?Asp?Met?Gly?Gly?Ser?Ala

100 105 110

Ser?Val?Leu?Ala?Thr?Ile?Ile?Ala?Ala?Ala?Arg?Leu?Asn?Leu?Ser?Ile

115 120 125

Asn?Val?Phe?Ala?Phe?Leu?Pro?Met?Ala?Glu?Asn?Met?Pro?Ser?Gly?Asp

130 135 140

Ala?Phe?Arg?Pro?Gly?Asp?Val?Ile?Thr?His?Phe?Gly?Gly?Ile?Thr?Ser

145 150 155 160

Glu?Ile?Leu?Asn?Thr?Asp?Ala?Glu?Gly?Arg?Leu?Ile?Leu?Ala?Asp?Ala

165 170 175

Ile?Ala?Tyr?Ala?Ser?Glu?Asp?Lys?Pro?Asp?Tyr?Leu?Ile?Asp?Ala?Ala

180 185 190

Thr?Leu?Thr?Gly?Ala?Gln?Leu?Val?Ala?Leu?Gly?Leu?Arg?Thr?Ser?Gly

195 200 205

Val?Met?Gly?Thr?Asp?Glu?Phe?Arg?Asp?Ser?Val?Ala?Lys?Thr?Gly?Arg

210 215 220

Glu?Val?Gly?Glu?Gln?Ala?Trp?Ala?Met?Pro?Leu?Pro?Glu?Glu?Leu?Asp

225 230 235 240

Glu?Gln?Val?Lys?Ser?Pro?Val?Ala?Asp?Leu?Arg?Asn?Val?Thr?Asn?Ser

245 250 255

Arg?Phe?Ala?Gly?Met?Ser?Ala?Ala?Gly?Arg?Tyr?Leu?Gln?Glu?Phe?Val

260 265 270

Gly?Ala?Asp?Ile?Glu?Trp?Ala?His?Val?Asp?Ile?Ala?Gly?Pro?Ala?Tyr

275 280 285

Asn?Thr?Ala?Gly?Glu?Phe?Gly?Tyr?Thr?Pro?Lys?Arg?Ala?Thr?Gly?Gln

290 295 300

Pro?Val?Arg?Thr?Phe?Val?Gln?Val?Leu?Lys?Asp?Leu?Ser?Glu?Ser

305 310 315

<210>117

<211>2127

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(2104)

<223>RXN01277

<400>117

tactactcgg?ttcacgttta?cgtcggctga?tccaattgga?ggcgccctcg?gaagccgcct?60

taaaaaacct?gccggtcaaa?agatcactaa?cctgaacttc?atg?act?gat?tac?acg 115

Met?Thr?Asp?Tyr?Thr

1 5

ttc?ctc?gaa?gac?att?gac?acc?ccg?gaa?gcg?ctc?gcg?tgg?gcg?gaa?aaa 163

Phe?Leu?Glu?Asp?Ile?Asp?Thr?Pro?Glu?Ala?Leu?Ala?Trp?Ala?Glu?Lys

10 15 20

tgg?tcg?ggg?gaa?agc?gtc?gaa?aag?cta?aaa?agc?cca?gcc?aag?gac?gcc 211

Trp?Ser?Gly?Glu?Ser?Val?Glu?Lys?Leu?Lys?Ser?Pro?Ala?Lys?Asp?Ala

25 30 35

ctg?gaa?gcc?agg?ctg?ctg?gct?gcg?ttg?gac?acc?gat?gat?cgc?att?gcc 259

Leu?Glu?Ala?Arg?Leu?Leu?Ala?Ala?Leu?Asp?Thr?Asp?Asp?Arg?Ile?Ala

40 45 50

tac?gtg?agc?cgg?cgc?ggt?gag?aag?ctg?tac?aac?ttt?tgg?cgg?gac?gcg 307

Tyr?Val?Ser?Arg?Arg?Gly?Glu?Lys?Leu?Tyr?Asn?Phe?Trp?Arg?Asp?Ala

55 60 65

cag?cat?ccg?cgt?gga?gtg?tgg?cgc?acg?acc?acg?ttg?gag?tcg?tat?gaa 355

Gln?His?Pro?Arg?Gly?Val?Trp?Arg?Thr?Thr?Thr?Leu?Glu?Ser?Tyr?Glu

70 75 80 85

agt?gac?cag?ccg?gag?tgg?gac?gtg?ctc?att?gat?gtg?gat?gcg?ttg?gcg 403

Ser?Asp?Gln?Pro?Glu?Trp?Asp?Val?Leu?Ile?Asp?Val?Asp?Ala?Leu?Ala

90 95 100

gag?gat?gag?ggc?gaa?aac?tgg?gta?tgg?aag?ggc?gcg?gtt?gtg?cgc?tcg 451

Glu?Asp?Glu?Gly?Glu?Asn?Trp?Val?Trp?Lys?Gly?Ala?Val?Val?Arg?Ser

105 110 115

ccg?gag?ttt?gat?cgg?gcg?ttg?gtg?aag?ttc?tcg?cgg?ggc?ggg?gct?gat 499

Pro?Glu?Phe?Asp?Arg?Ala?Leu?Val?Lys?Phe?Ser?Arg?Gly?Gly?Ala?Asp

120 125 130

gcg?acg?gtg?att?agg?gag?ttt?gat?ctg?gcc?acg?gct?gct?ttc?gtg?gat 547

Ala?Thr?Val?Ile?Arg?Glu?Phe?Asp?Leu?Ala?Thr?Ala?Ala?Phe?Val?Asp

135 140 145

gat?tcg?ccg?ttt?gaa?ttg?aag?gag?gcg?aag?tcc?gat?gtc?acg?tgg?gtt 595

Asp?Ser?Pro?Phe?Glu?Leu?Lys?Glu?Ala?Lys?Ser?Asp?Val?Thr?Trp?Val

150 155 160 165

gat?ctg?gat?acg?ttg?ctg?gtg?ggc?acg?gat?acc?ggc?gag?ggg?tca?ctg 643

Asp?Leu?Asp?Thr?Leu?Leu?Val?Gly?Thr?Asp?Thr?Gly?Glu?Gly?Ser?Leu

170 175 180

acg?gat?tct?ggg?tac?ccg?gcg?cgg?gtg?ctc?acg?tgg?aag?cgt?ggg?act 691

Thr?Asp?Ser?Gly?Tyr?Pro?Ala?Arg?Val?Leu?Thr?Trp?Lys?Arg?Gly?Thr

185 190 195

ccg?ctt?gag?cag?gcg?gag?ttg?ttc?ttt?gag?ggg?tcg?cgt?cag?gat?gtg 739

Pro?Leu?Glu?Gln?Ala?Glu?Leu?Phe?Phe?Glu?Gly?Ser?Arg?Gln?Asp?Val

200 205 210

gcg?act?cat?gcg?tgg?cgg?gat?tca?aca?cct?ggt?ttt?gag?cgg?acg?ttt 787

Ala?Thr?His?Ala?Trp?Arg?Asp?Ser?Thr?Pro?Gly?Phe?Glu?Arg?Thr?Phe

215 220 225

gtg?tca?agg?tcg?ttg?gat?ttc?tat?aat?tcg?gag?acg?tcg?ctg?gaa?acc 835

Val?Ser?Arg?Ser?Leu?Asp?Phe?Tyr?Asn?Ser?Glu?Thr?Ser?Leu?Glu?Thr

230 235 240 245

gag?ggt?ggc?ctg?gtc?aag?ctt?gat?gtg?ccg?acc?gat?tgc?gat?gtc?att 883

Glu?Gly?Gly?Leu?Val?Lys?Leu?Asp?Val?Pro?Thr?Asp?Cys?Asp?Val?Ile

250 255 260

gtg?aag?aag?cag?tgg?att?ttt?gtg?agt?cct?cgg?acg?gat?ttc?gct?ggg 931

Val?Lys?Lys?Gln?Trp?Ile?Phe?Val?Ser?Pro?Arg?Thr?Asp?Phe?Ala?Gly

265 270 275

att?cca?gca?ggt?ggc?ttg?gga?gtg?ctg?ctg?tta?aag?gag?ttc?ctt?gag 979

Ile?Pro?Ala?Gly?Gly?Leu?Gly?Val?Leu?Leu?Leu?Lys?Glu?Phe?Leu?Glu

280 285 290

ggc?ggg?cgc?gat?ttt?cag?cct?gtg?ttt?acg?cct?act?gag?tcg?acg?tcg 1027

Gly?Gly?Arg?Asp?Phe?Gln?Pro?Val?Phe?Thr?Pro?Thr?Glu?Ser?Thr?Ser

295 300 305

ctg?cag?gga?ttg?gcc?acg?aca?aag?aat?ttc?ctg?gtt?tta?acg?ctc?ctt 1075

Leu?Gln?Gly?Leu?Ala?Thr?Thr?Lys?Asn?Phe?Leu?Val?Leu?Thr?Leu?Leu

310 315 320 325

aat?aat?gtc?tcc?aca?gaa?atc?gtc?aca?gtg?ccg?ctc?aat?gat?ccg?aca 1123

Asn?Asn?Val?Ser?Thr?Glu?Ile?Val?Thr?Val?Pro?Leu?Asn?Asp?Pro?Thr

330 335 340

acg?gag?cat?gaa?cac?att?gac?ctc?cca?gag?cat?gtc?acc?gcg?cat?gtg 1171

Thr?Glu?His?Glu?His?Ile?Asp?Leu?Pro?Glu?His?Val?Thr?Ala?His?Val

345 350 355

gtt?gct?acc?tcc?ccg?ttg?gat?ggc?gat?gaa?att?tgg?gtg?cag?gca?gcg 1219

Val?Ala?Thr?Ser?Pro?Leu?Asp?Gly?Asp?Glu?Ile?Trp?Val?Gln?Ala?Ala

360 365 370

agt?ttc?acc?gaa?gcg?cca?acg?ttg?ctg?cgt?gcg?gag?ctg?cct?ggt?gcg 1267

Ser?Phe?Thr?Glu?Ala?Pro?Thr?Leu?Leu?Arg?Ala?Glu?Leu?Pro?Gly?Ala

375 380 385

ctt?gag?gct?gtg?aag?aag?gcg?ccg?ttg?cag?ttt?gaa?aat?gct?ggt?cag 1315

Leu?Glu?Ala?Val?Lys?Lys?Ala?Pro?Leu?Gln?Phe?Glu?Asn?Ala?Gly?Gln

390 395 400 405

gag?act?cgt?cag?cat?tgg?gca?acc?tcg?gcg?gat?gga?acg?aag?att?ccg 1363

Glu?Thr?Arg?Gln?His?Trp?Ala?Thr?Ser?Ala?Asp?Gly?Thr?Lys?Ile?Pro

410 415 420

tac?ttt?att?aca?gga?gcc?ttc?gag?gag?gaa?cca?caa?aac?acc?ctg?gtc 1411

Tyr?Phe?Ile?Thr?Gly?Ala?Phe?Glu?Glu?Glu?Pro?Gln?Asn?Thr?Leu?Val

425 430 435

cac?gcc?tac?ggc?ggc?ttc?gag?gtt?tcc?ctt?acc?cca?agc?cac?tcc?ccg 1459

His?Ala?Tyr?Gly?Gly?Phe?Glu?Val?Ser?Leu?Thr?Pro?Ser?His?Ser?Pro

440 445 450

acc?cgc?ggc?atc?gca?tgg?ttg?gaa?aag?ggc?tac?tac?ttt?gtg?gaa?gcc 1507

Thr?Arg?Gly?Ile?Ala?Trp?Leu?Glu?Lys?Gly?Tyr?Tyr?Phe?Val?Glu?Ala

455 460 465

aac?ctg?cgt?ggt?ggc?ggt?gaa?ttc?ggt?ccg?gaa?tgg?cat?tcg?cag?gca 1555

Asn?Leu?Arg?Gly?Gly?Gly?Glu?Phe?Gly?Pro?Glu?Trp?His?Ser?Gln?Ala

470 475 480 485

acc?aag?ctg?aac?cgc?atg?aag?gtg?tgg?gag?gat?cac?cgc?gcg?gtg?ctc 1603

Thr?Lys?Leu?Asn?Arg?Met?Lys?Val?Trp?Glu?Asp?His?Arg?Ala?Val?Leu

490 495 500

gcc?gac?ctt?gtg?gag?cgc?ggc?tac?gca?acg?ccg?gag?cag?att?gcg?att 1651

Ala?Asp?Leu?Val?Glu?Arg?Gly?Tyr?Ala?Thr?Pro?Glu?Gln?Ile?Ala?Ile

505 510 515

cgt?ggc?gga?tcc?aac?ggt?ggt?ttg?ctg?aca?agt?ggc?gcg?tta?act?cag 1699

Arg?Gly?Gly?Ser?Asn?Gly?Gly?Leu?Leu?Thr?Ser?Gly?Ala?Leu?Thr?Gln

520 525 530

tac?cca?gaa?gca?ttc?ggt?gcg?gca?gtt?gtg?cag?gtg?ccg?ttg?gct?gat 1747

Tyr?Pro?Glu?Ala?Phe?Gly?Ala?Ala?Val?Val?Gln?Val?Pro?Leu?Ala?Asp

535 540 545

atg?ttg?cgc?tat?cac?acc?tgg?tca?gcg?ggt?gct?tcg?tgg?atg?gcg?gag 1795

Met?Leu?Arg?Tyr?His?Thr?Trp?Ser?Ala?Gly?Ala?Ser?Trp?Met?Ala?Glu

550 555 560 565

tac?ggc?aac?cct?gac?gat?ccg?gag?gaa?cgg?gcg?gtg?att?gag?cag?tac 1843

Tyr?Gly?Asn?Pro?Asp?Asp?Pro?Glu?Glu?Arg?Ala?Val?Ile?Glu?Gln?Tyr

570 575 580

tcg?ccg?gtg?cag?gcg?gtg?gtg?ggc?gtc?gag?aag?cga?att?tat?cca?ccc 1891

Ser?Pro?Val?Gln?Ala?Val?Val?Gly?Val?Glu?Lys?Arg?Ile?Tyr?Pro?Pro

585 590 595

gca?ttg?gtg?acg?acc?tca?acc?cgg?gac?gac?cgc?gtc?cac?ccc?gcg?cac 1939

Ala?Leu?Val?Thr?Thr?Ser?Thr?Arg?Asp?Asp?Arg?Val?His?Pro?Ala?His

600 605 610

gcg?cgc?ctt?ttt?gct?caa?gct?ttg?ctt?gat?gcg?ggc?cag?gcc?gtg?gat 1987

Ala?Arg?Leu?Phe?Ala?Gln?Ala?Leu?Leu?Asp?Ala?Gly?Gln?Ala?Val?Asp

615 620 625

tac?tac?gaa?aac?acc?gag?ggc?ggc?cat?gcc?ggc?gcg?gcg?gat?aac?aag 2035

Tyr?Tyr?Glu?Asn?Thr?Glu?Gly?Gly?His?Ala?Gly?Ala?Ala?Asp?Asn?Lys

630 635 640 645

cag?acc?gcg?ttt?gtg?gaa?tcg?ctg?atc?tac?acc?tgg?atc?gag?aag?act 2083

Gln?Thr?Ala?Phe?Val?Glu?Ser?Leu?Ile?Tyr?Thr?Trp?Ile?Glu?Lys?Thr

650 655 660

ttg?gat?cag?cag?ggt?agc?att?taatacctat?gattatgcga?agg 2127

Leu?Asp?Gln?Gln?Gly?Ser?Ile

665

<210>118

<211>668

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>118

Met?Thr?Asp?Tyr?Thr?Phe?Leu?Glu?Asp?Ile?Asp?Thr?Pro?Glu?Ala?Leu

1 5 10 15

Ala?Trp?Ala?Glu?Lys?Trp?Ser?Gly?Glu?Ser?Val?Glu?Lys?Leu?Lys?Ser

20 25 30

Pro?Ala?Lys?Asp?Ala?Leu?Glu?Ala?Arg?Leu?Leu?Ala?Ala?Leu?Asp?Thr

35 40 45

Asp?Asp?Arg?Ile?Ala?Tyr?Val?Ser?Arg?Arg?Gly?Glu?Lys?Leu?Tyr?Asn

50 55 60

Phe?Trp?Arg?Asp?Ala?Gln?His?Pro?Arg?Gly?Val?Trp?Arg?Thr?Thr?Thr

65 70 75 80

Leu?Glu?Ser?Tyr?Glu?Ser?Asp?Gln?Pro?Glu?Trp?Asp?Val?Leu?Ile?Asp

85 90 95

Val?Asp?Ala?Leu?Ala?Glu?Asp?Glu?Gly?Glu?Asn?Trp?Val?Trp?Lys?Gly

100 105 110

Ala?Val?Val?Arg?Ser?Pro?Glu?Phe?Asp?Arg?Ala?Leu?Val?Lys?Phe?Ser

115 120 125

Arg?Gly?Gly?Ala?Asp?Ala?Thr?Val?Ile?Arg?Glu?Phe?Asp?Leu?Ala?Thr

130 135 140

Ala?Ala?Phe?Val?Asp?Asp?Ser?Pro?Phe?Glu?Leu?Lys?Glu?Ala?Lys?Ser

145 150 155 160

Asp?Val?Thr?Trp?Val?Asp?Leu?Asp?Thr?Leu?Leu?Val?Gly?Thr?Asp?Thr

165 170 175

Gly?Glu?Gly?Ser?Leu?Thr?Asp?Ser?Gly?Tyr?Pro?Ala?Arg?Val?Leu?Thr

180 185 190

Trp?Lys?Arg?Gly?Thr?Pro?Leu?Glu?Gln?Ala?Glu?Leu?Phe?Phe?Glu?Gly

195 200 205

Ser?Arg?Gln?Asp?Val?Ala?Thr?His?Ala?Trp?Arg?Asp?Ser?Thr?Pro?Gly

2l0 215 220

Phe?Glu?Arg?Thr?Phe?Val?Ser?Arg?Ser?Leu?Asp?Phe?Tyr?Asn?Ser?Glu

225 230 235 240

Thr?Ser?Leu?Glu?Thr?Glu?Gly?Gly?Leu?Val?Lys?Leu?Asp?Val?Pro?Thr

245 250 255

Asp?Cys?Asp?Val?Ile?Val?Lys?Lys?Gln?Trp?Ile?Phe?Val?Ser?Pro?Arg

260 265 270

Thr?Asp?Phe?Ala?Gly?Ile?Pro?Ala?Gly?Gly?Leu?Gly?Val?Leu?Leu?Leu

275 280 285

Lys?Glu?Phe?Leu?Glu?Gly?Gly?Arg?Asp?Phe?Gln?Pro?Val?Phe?Thr?Pro

290 295 300

Thr?Glu?Ser?Thr?Ser?Leu?Gln?Gly?Leu?Ala?Thr?Thr?Lys?Asn?Phe?Leu

305 310 315 320

Val?Leu?Thr?Leu?Leu?Asn?Asn?Val?Ser?Thr?Glu?Ile?Val?Thr?Val?Pro

325 330 335

Leu?Asn?Asp?Pro?Thr?Thr?Glu?His?Glu?His?Ile?Asp?Leu?Pro?Glu?His

340 345 350

Val?Thr?Ala?His?Val?Val?Ala?Thr?Ser?Pro?Leu?Asp?Gly?Asp?Glu?Ile

355 360 365

Trp?Val?Gln?Ala?Ala?Ser?Phe?Thr?Glu?Ala?Pro?Thr?Leu?Leu?Arg?Ala

370 375 380

Glu?Leu?Pro?Gly?Ala?Leu?Glu?Ala?Val?Lys?Lys?Ala?Pro?Leu?Gln?Phe

385 390 395 400

Glu?Asn?Ala?Gly?Gln?Glu?Thr?Arg?Gln?His?Trp?Ala?Thr?Ser?Ala?Asp

405 410 415

Gly?Thr?Lys?Ile?Pro?Tyr?Phe?Ile?Thr?Gly?Ala?Phe?Glu?Glu?Glu?Pro

420 425 430

Gln?Asn?Thr?Leu?Val?His?Ala?Tyr?Gly?Gly?Phe?Glu?Val?Ser?Leu?Thr

435 440 445

Pro?Ser?His?Ser?Pro?Thr?Arg?Gly?Ile?Ala?Trp?Leu?Glu?Lys?Gly?Tyr

450 455 460

Tyr?Phe?Val?Glu?Ala?Asn?Leu?Arg?Gly?Gly?Gly?Glu?Phe?Gly?Pro?Glu

465 470 475 480

Trp?His?Ser?Gln?Ala?Thr?Lys?Leu?Asn?Arg?Met?Lys?Val?Trp?Glu?Asp

485 490 495

His?Arg?Ala?Val?Leu?Ala?Asp?Leu?Val?Glu?Arg?Gly?Tyr?Ala?Thr?Pro

500 505 510

Glu?Gln?Ile?Ala?Ile?Arg?Gly?Gly?Ser?Asn?Gly?Gly?Leu?Leu?Thr?Ser

515 520 525

Gly?Ala?Leu?Thr?Gln?Tyr?Pro?Glu?Ala?Phe?Gly?Ala?Ala?Val?Val?Gln

530 535 540

Val?Pro?Leu?Ala?Asp?Met?Leu?Arg?Tyr?His?Thr?Trp?Ser?Ala?Gly?Ala

545 550 555 560

Ser?Trp?Met?Ala?Glu?Tyr?Gly?Asn?Pro?Asp?Asp?Pro?Glu?Glu?Arg?Ala

565 570 575

Val?Ile?Glu?Gln?Tyr?Ser?Pro?Val?Gln?Ala?Val?Val?Gly?Val?Glu?Lys

580 585 590

Arg?Ile?Tyr?Pro?Pro?Ala?Leu?Val?Thr?Thr?Ser?Thr?Arg?Asp?Asp?Arg

595 600 605

Val?His?Pro?Ala?His?Ala?Arg?Leu?Phe?Ala?Gln?Ala?Leu?Leu?Asp?Ala

610 615 620

Gly?Gln?Ala?Val?Asp?Tyr?Tyr?Glu?Asn?Thr?Glu?Gly?Gly?His?Ala?Gly

625 630 635 640

Ala?Ala?Asp?Asn?Lys?Gln?Thr?Ala?Phe?Val?Glu?Ser?Leu?Ile?Tyr?Thr

645 650 655

Trp?Ile?Glu?Lys?Thr?Leu?Asp?Gln?Gln?Gly?Ser?Ile

660 665

<210>119

<211>1812

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1789)

<223>FRXA01277

<400>119

tactactcgg?ttcacgttta?cgtcggctga?tccaattgga?ggcgccctcg?gaagccgcct?60

taaaaaacct?gccggtcaaa?agatcactaa?cctgaacttc?atg?act?gat?tac?acg 115

Met?Thr?Asp?Tyr?Thr

1 5

ttc?ctc?gaa?gac?att?gac?acc?ccg?gaa?gcg?ctc?gcg?tgg?gcg?gaa?aaa 163

Phe?Leu?Glu?Asp?Ile?Asp?Thr?Pro?Glu?Ala?Leu?Ala?Trp?Ala?Glu?Lys

10 15 20

tgg?tcg?ggg?gaa?agc?gtc?gaa?aag?cta?aaa?agc?cca?gcc?aag?gac?gcc 211

Trp?Ser?Gly?Glu?Ser?Val?Glu?Lys?Leu?Lys?Ser?Pro?Ala?Lys?Asp?Ala

25 30 35

ctg?gaa?gcc?agg?ctg?ctg?gct?gcg?ttg?gac?acc?gat?gat?cgc?att?gcc 259

Leu?Glu?Ala?Arg?Leu?Leu?Ala?Ala?Leu?Asp?Thr?Asp?Asp?Arg?Ile?Ala

40 45 50

tac?gtg?agc?cgg?cgc?ggt?gag?aag?ctg?tac?aac?ttt?tgg?cgg?gac?gcg 307

Tyr?Val?Ser?Arg?Arg?Gly?Glu?Lys?Leu?Tyr?Asn?Phe?Trp?Arg?Asp?Ala

55 60 65

cag?cat?ccg?cgt?gga?gtg?tgg?cgc?acg?acc?acg?ttg?gag?tcg?tat?gaa 355

Gln?His?Pro?Arg?Gly?Val?Trp?Arg?Thr?Thr?Thr?Leu?Glu?Ser?Tyr?Glu

70 75 80 85

agt?gac?cag?ccg?gag?tgg?gac?gtg?ctc?att?gat?gtg?gat?gcg?ttg?gcg 403

Ser?Asp?Gln?Pro?Glu?Trp?Asp?Val?Leu?Ile?Asp?Val?Asp?Ala?Leu?Ala

90 95 100

gag?gat?gag?ggc?gaa?aac?tgg?gta?tgg?aag?ggc?gcg?gtt?gtg?cgc?tcg 451

Glu?Asp?Glu?Gly?Glu?Asn?Trp?Val?Trp?Lys?Gly?Ala?Val?Val?Arg?Ser

105 110 115

ccg?gag?ttt?gat?cgg?gcg?ttg?gtg?aag?ttc?tcg?cgg?ggc?ggg?gct?gat 499

Pro?Glu?Phe?Asp?Arg?Ala?Leu?Val?Lys?Phe?Ser?Arg?Gly?Gly?Ala?Asp

120 125 130

gcg?acg?gtg?att?agg?gag?ttt?gat?ctg?gcc?acg?gct?gct?ttc?gtg?gat 547

Ala?Thr?Val?Ile?Arg?Glu?Phe?Asp?Leu?Ala?Thr?Ala?Ala?Phe?Val?Asp

135 140 145

gat?tcg?ccg?ttt?gaa?ttg?aag?gag?gcg?aag?tcc?gat?gtc?acg?tgg?gtt 595

Asp?Ser?Pro?Phe?Glu?Leu?Lys?Glu?Ala?Lys?Ser?Asp?Val?Thr?Trp?Val

150 155 160 165

gat?ctg?gat?acg?ttg?ctg?gtg?ggc?acg?gat?acc?ggc?gag?ggg?tca?ctg 643

Asp?Leu?Asp?Thr?Leu?Leu?Val?Gly?Thr?Asp?Thr?Gly?Glu?Gly?Ser?Leu

170 175 180

acg?gat?tct?ggg?tac?ccg?gcg?cgg?gtg?ctc?acg?tgg?aag?cgt?ggg?act 691

Thr?Asp?Ser?Gly?Tyr?Pro?Ala?Arg?Val?Leu?Thr?Trp?Lys?Arg?Gly?Thr

185 190 195

ccg?ctt?gag?cag?gcg?gag?ttg?ttc?ttt?gag?ggg?tcg?cgt?cag?gat?gtg 739

Pro?Leu?Glu?Gln?Ala?Glu?Leu?Phe?Phe?Glu?Gly?Ser?Arg?Gln?Asp?Val

200 205 210

gcg?act?cat?gcg?tgg?cgg?gat?tca?aca?cct?ggt?ttt?gag?cgg?acg?ttt 787

Ala?Thr?His?Ala?Trp?Arg?Asp?Ser?Thr?Pro?Gly?Phe?Glu?Arg?Thr?Phe

215 220 225

gtg?tca?agg?tcg?ttg?gat?ttc?tat?aat?tcg?gag?acg?tcg?ctg?gaa?acc 835

Val?Ser?Arg?Ser?Leu?Asp?Phe?Tyr?Asn?Ser?Glu?Thr?Ser?Leu?Glu?Thr

230 235 240 245

gag?ggt?ggc?ctg?gtc?aag?ctt?gat?gtg?ccg?acc?gat?tgc?gat?gtc?att 883

Glu?Gly?Gly?Leu?Val?Lys?Leu?Asp?Val?Pro?Thr?Asp?Cys?Asp?Val?Ile

250 255 260

gtg?aag?aag?cag?tgg?att?ttt?gtg?agt?cct?cgg?acg?gat?ttc?gct?ggg 931

Val?Lys?Lys?Gln?Trp?Ile?Phe?Val?Ser?Pro?Arg?Thr?Asp?Phe?Ala?Gly

265 270 275

att?cca?gca?ggt?ggc?ttg?gga?gtg?ctg?ctg?tta?aag?gag?ttc?ctt?gag 979

Ile?Pro?Ala?Gly?Gly?Leu?Gly?Val?Leu?Leu?Leu?Lys?Glu?Phe?Leu?Glu

280 285 290

ggc?ggg?cgc?gat?ttt?cag?cct?gtg?ttt?acg?cct?act?gag?tcg?acg?tcg 1027

Gly?Gly?Arg?Asp?Phe?Gln?Pro?Val?Phe?Thr?Pro?Thr?Glu?Ser?Thr?Ser

295 300 305

ctg?cag?gga?ttg?gcc?acg?aca?aag?aat?ttc?ctg?gtt?tta?acg?ctc?ctt 1075

Leu?Gln?Gly?Leu?Ala?Thr?Thr?Lys?Asn?Phe?Leu?Val?Leu?Thr?Leu?Leu

310 315 320 325

aat?aat?gtc?tcc?aca?gaa?atc?gtc?aca?gtg?ccg?ctc?aat?gat?ccg?aca 1123

Asn?Asn?Val?Ser?Thr?Glu?Ile?Val?Thr?Val?Pro?Leu?Asn?Asp?Pro?Thr

330 335 340

acg?gag?cat?gaa?cac?att?gac?ctc?cca?gag?cat?gtc?acc?gcg?cat?gtg 1171

Thr?Glu?His?Glu?His?Ile?Asp?Leu?Pro?Glu?His?Val?Thr?Ala?His?Val

345 350 355

gtt?gct?acc?tcc?ccg?ttg?gat?ggc?gat?gaa?att?tgg?gtg?cag?gca?gcg 1219

Val?Ala?Thr?Ser?Pro?Leu?Asp?Gly?Asp?Glu?Ile?Trp?Val?Gln?Ala?Ala

360 365 370

agt?ttc?acc?gaa?gcg?cca?acg?ttg?ctg?cgt?gcg?gag?ctg?cct?ggt?gcg 1267

Ser?Phe?Thr?Glu?Ala?Pro?Thr?Leu?Leu?Arg?Ala?Glu?Leu?Pro?Gly?Ala

375 380 385

ctt?gag?gct?gtg?aag?aag?gcg?ccg?ttg?cag?ttt?gaa?aat?gct?ggt?cag 1315

Leu?Glu?Ala?Val?Lys?Lys?Ala?Pro?Leu?Gln?Phe?Glu?Asn?Ala?Gly?Gln

390 395 400 405

gag?act?cgt?cag?cat?tgg?gca?acc?tcg?gcg?gat?gga?acg?aag?att?ccg 1363

Glu?Thr?Arg?Gln?His?Trp?Ala?Thr?Ser?Ala?Asp?Gly?Thr?Lys?Ile?Pro

410 415 420

tac?ttt?att?aca?gga?gcc?ttc?gag?gag?gaa?cca?caa?aac?acc?ctg?gtc 1411

Tyr?Phe?Ile?Thr?Gly?Ala?Phe?Glu?Glu?Glu?Pro?Gln?Asn?Thr?Leu?Val

425 430 435

cac?gcc?tac?ggc?ggc?ttc?gag?gtt?tcc?ctt?acc?cca?agc?cac?tcc?ccg 1459

His?Ala?Tyr?Gly?Gly?Phe?Glu?Val?Ser?Leu?Thr?Pro?Ser?His?Ser?Pro

440 445 450

acc?cgc?ggc?atc?gca?tgg?ttg?gaa?aag?ggc?tac?tac?ttt?gtg?gaa?gcc 1507

Thr?Arg?Gly?Ile?Ala?Trp?Leu?Glu?Lys?Gly?Tyr?Tyr?Phe?Val?Glu?Ala

455 460 465

aac?ctg?cgt?ggt?ggc?ggt?gaa?ttc?ggt?ccg?gaa?tgg?cat?tcg?cag?gca 1555

Asn?Leu?Arg?Gly?Gly?Gly?Glu?Phe?Gly?Pro?Glu?Trp?His?Ser?Gln?Ala

470 475 480 485

acc?aag?ctg?aac?cgc?atg?aag?gtg?tgg?gag?gat?cac?cgc?gcg?gtg?ctc 1603

Thr?Lys?Leu?Asn?Arg?Met?Lys?Val?Trp?Glu?Asp?His?Arg?Ala?Val?Leu

490 495 500

gcc?gac?ctt?gtg?gag?cgc?ggc?tac?gca?acg?ccg?gag?cag?att?gcg?att 1651

Ala?Asp?Leu?Val?Glu?Arg?Gly?Tyr?Ala?Thr?Pro?Glu?Gln?Ile?Ala?Ile

505 510 515

cgt?ggc?gga?tcc?aac?ggt?ggt?ttg?ctg?aca?agt?ggc?gcg?tta?act?cag 1699

Arg?Gly?Gly?Ser?Asn?Gly?Gly?Leu?Leu?Thr?Ser?Gly?Ala?Leu?Thr?Gln

520 525 530

tac?cca?gaa?gca?ttc?ggt?gcg?gca?gtt?gtg?cag?gtg?ccg?ttg?gct?gat 1747

Tyr?Pro?Glu?Ala?Phe?Gly?Ala?Ala?Val?Val?Gln?Val?Pro?Leu?Ala?Asp

535 540 545

atg?ttg?cgc?tat?cac?acc?tgg?tca?gcg?ggt?acc?tcg?tgg?atg 1789

Met?Leu?Arg?Tyr?His?Thr?Trp?Ser?Ala?Gly?Thr?Ser?Trp?Met

550 555 560

taggtgtcgg?caaccatggg?aac 1812

<210>120

<211>563

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>120

Met?Thr?Asp?Tyr?Thr?Phe?Leu?Glu?Asp?Ile?Asp?Thr?Pro?Glu?Ala?Leu

1 5 10 15

Ala?Trp?Ala?Glu?Lys?Trp?Ser?Gly?Glu?Ser?Val?Glu?Lys?Leu?Lys?Ser

20 25 30

Pro?Ala?Lys?Asp?Ala?Leu?Glu?Ala?Arg?Leu?Leu?Ala?Ala?Leu?Asp?Thr

35 40 45

Asp?Asp?Arg?Ile?Ala?Tyr?Val?Ser?Arg?Arg?Gly?Glu?Lys?Leu?Tyr?Asn

50 55 60

Phe?Trp?Arg?Asp?Ala?Gln?His?Pro?Arg?Gly?Val?Trp?Arg?Thr?Thr?Thr

65 70 75 80

Leu?Glu?Ser?Tyr?Glu?Ser?Asp?Gln?Pro?Glu?Trp?Asp?Val?Leu?Ile?Asp

85 90 95

Val?Asp?Ala?Leu?Ala?Glu?Asp?Glu?Gly?Glu?Asn?Trp?Val?Trp?Lys?Gly

100 105 110

Ala?Val?Val?Arg?Ser?Pro?Glu?Phe?Asp?Arg?Ala?Leu?Val?Lys?Phe?Ser

115 120 125

Arg?Gly?Gly?Ala?Asp?Ala?Thr?Val?Ile?Arg?Glu?Phe?Asp?Leu?Ala?Thr

130 135 140

Ala?Ala?Phe?Val?Asp?Asp?Ser?Pro?Phe?Glu?Leu?Lys?Glu?Ala?Lys?Ser

145 150 155 160

Asp?Val?Thr?Trp?Val?Asp?Leu?Asp?Thr?Leu?Leu?Val?Gly?Thr?Asp?Thr

165 170 175

Gly?Glu?Gly?Ser?Leu?Thr?Asp?Ser?Gly?Tyr?Pro?Ala?Arg?Val?Leu?Thr

180 185 190

Trp?Lys?Arg?Gly?Thr?Pro?Leu?Glu?Gln?Ala?Glu?Leu?Phe?Phe?Glu?Gly

195 200 205

Ser?Arg?Gln?Asp?Val?Ala?Thr?His?Ala?Trp?Arg?Asp?Ser?Thr?Pro?Gly

210 215 220

Phe?Glu?Arg?Thr?Phe?Val?Ser?Arg?Ser?Leu?Asp?Phe?Tyr?Asn?Ser?Glu

225 230 235 240

Thr?Ser?Leu?Glu?Thr?Glu?Gly?Gly?Leu?Val?Lys?Leu?Asp?Val?Pro?Thr

245 250 255

Asp?Cys?Asp?Val?Ile?Val?Lys?Lys?Gln?Trp?Ile?Phe?Val?Ser?Pro?Arg

260 265 270

Thr?Asp?Phe?Ala?Gly?Ile?Pro?Ala?Gly?Gly?Leu?Gly?Val?Leu?Leu?Leu

275 280 285

Lys?Glu?Phe?Leu?Glu?Gly?Gly?Arg?Asp?Phe?Gln?Pro?Val?Phe?Thr?Pro

290 295 300

Thr?Glu?Ser?Thr?Ser?Leu?Gln?Gly?Leu?Ala?Thr?Thr?Lys?Asn?Phe?Leu

305 310 315 320

Val?Leu?Thr?Leu?Leu?Asn?Asn?Val?Ser?Thr?Glu?Ile?Val?Thr?Val?Pro

325 330 335

Leu?Asn?Asp?Pro?Thr?Thr?Glu?His?Glu?His?Ile?Asp?Leu?Pro?Glu?His

340 345 350

Val?Thr?Ala?His?Val?Val?Ala?Thr?Ser?Pro?Leu?Asp?Gly?Asp?Glu?Ile

355 360 365

Trp?Val?Gln?Ala?Ala?Ser?Phe?Thr?Glu?Ala?Pro?Thr?Leu?Leu?Arg?Ala

370 375 380

Glu?Leu?Pro?Gly?Ala?Leu?Glu?Ala?Val?Lys?Lys?Ala?Pro?Leu?Gln?Phe

385 390 395 400

Glu?Asn?Ala?Gly?Gln?Glu?Thr?Arg?Gln?His?Trp?Ala?Thr?Ser?Ala?Asp

405 410 415

Gly?Thr?Lys?Ile?Pro?Tyr?Phe?Ile?Thr?Gly?Ala?Phe?Glu?Glu?Glu?Pro

420 425 430

Gln?Asn?Thr?Leu?Val?His?Ala?Tyr?Gly?Gly?Phe?Glu?Val?Ser?Leu?Thr

435 440 445

Pro?Ser?His?Ser?Pro?Thr?Arg?Gly?Ile?Ala?Trp?Leu?Glu?Lys?Gly?Tyr

450 455 460

Tyr?Phe?Val?Glu?Ala?Asn?Leu?Arg?Gly?Gly?Gly?Glu?Phe?Gly?Pro?Glu

465 470 475 480

Trp?His?Ser?Gln?Ala?Thr?Lys?Leu?Asn?Arg?Met?Lys?Val?Trp?Glu?Asp

485 490 495

His?Arg?Ala?Val?Leu?Ala?Asp?Leu?Val?Glu?Arg?Gly?Tyr?Ala?Thr?Pro

500 505 510

Glu?Gln?Ile?Ala?Ile?Arg?Gly?Gly?Ser?Asn?Gly?Gly?Leu?Leu?Thr?Ser

515 520 525

Gly?Ala?Leu?Thr?Gln?Tyr?Pro?Glu?Ala?Phe?Gly?Ala?Ala?Val?Val?Gln

530 535 540

Val?Pro?Leu?Ala?Asp?Met?Leu?Arg?Tyr?His?Thr?Trp?Ser?Ala?Gly?Thr

545 550 555 560

Ser?Trp?Met

<210>121

<211>526

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(526)

<223>RXA01914

<400>121

ggttttgagg?aatggctagg?cttgttaaaa?gttagtttca?atttgatgcc?tcccccaacc?60

aaagcggaga?cacaacttca?acgagaggac?tcagctttca?atg?gcg?aaa?aat?gcc 115

Met?Ala?Lys?Asn?Ala

1 5

tac?agc?aca?aca?gca?cca?acc?aag?gtg?tcc?aag?gat?gcc?act?ctt?cca 163

Tyr?Ser?Thr?Thr?Ala?Pro?Thr?Lys?Val?Ser?Lys?Asp?Ala?Thr?Leu?Pro

10 15 20

gtt?cgt?gga?acg?gtc?gct?gaa?ctc?aag?ctc?gaa?aag?aag?ttg?cca?aag 211

Val?Arg?Gly?Thr?Val?Ala?Glu?Leu?Lys?Leu?Glu?Lys?Lys?Leu?Pro?Lys

25 30 35

aag?att?gat?gcc?atc?atc?gtc?gcg?att?ttt?gaa?ggc?gaa?gat?tcc?atc 259

Lys?Ile?Asp?Ala?Ile?Ile?Val?Ala?Ile?Phe?Glu?Gly?Glu?Asp?Ser?Ile

40 45 50

gaa?ctc?gcc?ggc?ggc?gaa?atc?ctc?gat?ttc?atc?ttc?agt?acc?gag?cag 307

Glu?Leu?Ala?Gly?Gly?Glu?Ile?Leu?Asp?Phe?Ile?Phe?Ser?Thr?Glu?Gln

55 60 65

cag?gcc?gac?atc?ctc?act?cag?ctc?gaa?gct?gtc?ggc?gca?aag?gcc?acc 355

Gln?Ala?Asp?Ile?Leu?Thr?Gln?Leu?Glu?Ala?Val?Gly?Ala?Lys?Ala?Thr

70 75 80 85

gca?aac?agc?atc?acc?cgc?gtc?cca?ggc?acc?gac?gtt?gcg?cct?gtc?att 403

Ala?Asn?Ser?Ile?Thr?Arg?Val?Pro?Gly?Thr?Asp?Val?Ala?Pro?Val?Ile

90 95 100

gcg?gtt?ggt?ttg?ggc?aag?gct?gat?ttg?ctt?gac?gac?gag?acc?ctc?cgc 451

Ala?Val?Gly?Leu?Gly?Lys?Ala?Asp?Leu?Leu?Asp?Asp?Glu?Thr?Leu?Arg

105 110 115

cgc?gct?tcc?ggc?acg?gcg?gcc?cgc?tcc?ctc?ggt?ggt?ttt?gaa?aat?gtc 499

Arg?Ala?Ser?Gly?Thr?Ala?Ala?Arg?Ser?Leu?Gly?Gly?Phe?Glu?Asn?Val

120 125 l30

gcc?acc?acc?att?ggc?gat?ttg?gga?ctt 526

Ala?Thr?Thr?Ile?Gly?Asp?Leu?Gly?Leu

135 140

<210>122

<211>142

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>122

Met?Ala?Lys?Asn?Ala?Tyr?Ser?Thr?Thr?Ala?Pro?Thr?Lys?Val?Ser?Lys

1 5 10 15

Asp?Ala?Thr?Leu?Pro?Val?Arg?Gly?Thr?Val?Ala?Glu?Leu?Lys?Leu?Glu

20 25 30

Lys?Lys?Leu?Pro?Lys?Lys?Ile?Asp?Ala?Ile?Ile?Val?Ala?Ile?Phe?Glu

35 40 45

Gly?Glu?Asp?Ser?Ile?Glu?Leu?Ala?Gly?Gly?Glu?Ile?Leu?Asp?Phe?Ile

50 55 60

Phe?Ser?Thr?Glu?Gln?Gln?Ala?Asp?Ile?Leu?Thr?Gln?Leu?Glu?Ala?Val

65 70 75 80

Gly?Ala?Lys?Ala?Thr?Ala?Asn?Ser?Ile?Thr?Arg?Val?Pro?Gly?Thr?Asp

85 90 95

Val?Ala?Pro?Val?Ile?Ala?Val?Gly?Leu?Gly?Lys?Ala?Asp?Leu?Leu?Asp

100 105 110

Asp?Glu?Thr?Leu?Arg?Arg?Ala?Ser?Gly?Thr?Ala?Ala?Arg?Ser?Leu?Gly

115 120 125

Gly?Phe?Glu?Asn?Val?Ala?Thr?Thr?Ile?Gly?Asp?Leu?Gly?Leu

130 135 140

<210>123

<211>1497

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1474)

<223>RXA02048

<400>123

gcgcggcgga?taacaagcag?accgcgtttg?tggaatcgct?gatctacacc?tggatcgaaa?60

agactttgga?tcagcagggt?agcatttaat?acctatgatt?atg?cga?agg?ctg?cgc 115

Met?Arg?Arg?Leu?Arg

1 5

tcc?acc?ccg?gtc?cct?ggt?aca?cgc?gat?tcc?tac?aca?gga?att?gat?ttc 163

Ser?Thr?Pro?Val?Pro?Gly?Thr?Arg?Asp?Ser?Tyr?Thr?Gly?Ile?Asp?Phe

10 15 20

aac?tta?ggc?ttc?cac?atc?cga?cgc?tac?gag?ctt?gat?ctc?acc?tac?cgc 211

Asn?Leu?Gly?Phe?His?Ile?Arg?Arg?Tyr?Glu?Leu?Asp?Leu?Thr?Tyr?Arg

25 30 35

gta?gca?ccc?aac?ctg?ctc?atg?ggc?acc?gca?acg?ctg?cac?atg?gat?aat 259

Val?Ala?Pro?Asn?Leu?Leu?Met?Gly?Thr?Ala?Thr?Leu?His?Met?Asp?Asn

40 45 50

tac?cgt?gcg?ctc?gac?gcg?ctg?acc?ctg?gac?ctc?ggc?ggc?agc?ctg?cgc 307

Tyr?Arg?Ala?Leu?Asp?Ala?Leu?Thr?Leu?Asp?Leu?Gly?Gly?Ser?Leu?Arg

55 60 65

gtg?gaa?aaa?gtc?acc?gcc?aaa?ggc?acc?gcc?ggc?acc?cac?atc?caa?gtc 355

Val?Glu?Lys?Val?Thr?Ala?Lys?Gly?Thr?Ala?Gly?Thr?His?Ile?Gln?Val

70 75 80 85

gcg?cgc?ttc?cgc?cac?gcc?ggc?cgc?aaa?ctg?cgc?atc?acc?ttc?cgc?aac 403

Ala?Arg?Phe?Arg?His?Ala?Gly?Arg?Lys?Leu?Arg?Ile?Thr?Phe?Arg?Asn

90 95 100

caa?atc?ccg?gtt?gac?cag?gaa?ttt?tca?ctc?acc?atc?cgc?tac?cgc?ggc 451

Gln?Ile?Pro?Val?Asp?Gln?Glu?Phe?Ser?Leu?Thr?Ile?Arg?Tyr?Arg?Gly

105 110 115

aac?ccg?cgc?ccc?ctg?cgc?agc?gaa?tgg?ggc?atg?atc?ggc?tgg?gaa?gag 499

Asn?Pro?Arg?Pro?Leu?Arg?Ser?Glu?Trp?Gly?Met?Ile?Gly?Trp?Glu?Glu

120 125 130

ctc?gac?aac?ggc?gcc?ctc?gtc?gcc?gcc?cag?cca?aac?ggc?gcg?ccg?agc 547

Leu?Asp?Asn?Gly?Ala?Leu?Val?Ala?Ala?Gln?Pro?Asn?Gly?Ala?Pro?Ser

135 140 145

tgg?ttc?ccc?tgc?gac?gac?acg?ccc?gac?gag?aag?gcg?ctt?ttc?gac?gtc 595

Trp?Phe?Pro?Cys?Asp?Asp?Thr?Pro?Asp?Glu?Lys?Ala?Leu?Phe?Asp?Val

150 155 160 165

cac?ttc?cac?acc?gac?aac?gga?tac?gcc?gcc?att?atc?acc?ggt?gat?tta 643

His?Phe?His?Thr?Asp?Asn?Gly?Tyr?Ala?Ala?Ile?Ile?Thr?Gly?Asp?Leu

170 175 180

atc?tca?aaa?cac?gtc?agt?ggc?agc?atg?acc?acc?tgg?cac?tac?caa?tcc 691

Ile?Ser?Lys?His?Val?Ser?Gly?Ser?Met?Thr?Thr?Trp?His?Tyr?Gln?Ser

185 190 195

cgc?gaa?ccc?atg?gcc?acc?tac?ctc?gca?gcc?gtc?cac?gtc?gga?gaa?tac 739

Arg?Glu?Pro?Met?Ala?Thr?Tyr?Leu?Ala?Ala?Val?His?Val?Gly?Glu?Tyr

200 205 210

gac?act?gta?tcc?ctg?ggc?gtt?tcg?gaa?tcg?ggc?gtt?gtg?gtg?gag?gcg 787

Asp?Thr?Val?Ser?Leu?Gly?Val?Ser?Glu?Ser?Gly?Val?Val?Val?Glu?Ala

215 220 225

tat?gtg?cct?gtg?ggg?gat?gcg?gcc?ttg?cgg?gct?cgg?att?ttg?gag?gac 835

Tyr?Val?Pro?Val?Gly?Asp?Ala?Ala?Leu?Arg?Ala?Arg?Ile?Leu?Glu?Asp

230 235 240 245

ttt?gcc?aaa?caa?gtc?gac?atg?tta?gac?gcc?tac?gaa?aaa?ctc?ttc?ggc 883

Phe?Ala?Lys?Gln?Val?Asp?Met?Leu?Asp?Ala?Tyr?Glu?Lys?Leu?Phe?Gly

250 255 260

ccc?tac?cca?ttc?cgc?agc?tac?cgc?gta?gtc?atc?acc?gaa?gac?gaa?ctc 931

Pro?Tyr?Pro?Phe?Arg?Ser?Tyr?Arg?Val?Val?Ile?Thr?Glu?Asp?Glu?Leu

265 270 275

gaa?atc?cca?ctc?gaa?gcc?caa?ggc?ctc?tcc?agc?ttc?gga?gcc?aac?cac 979

Glu?Ile?Pro?Leu?Glu?Ala?Gln?Gly?Leu?Ser?Ser?Phe?Gly?Ala?Asn?His

280 285 290

gcc?acc?ggc?gaa?gga?acc?tgg?gaa?cga?ctc?atc?gcc?cac?gaa?ctc?tcc 1027

Ala?Thr?Gly?Glu?Gly?Thr?Trp?Glu?Arg?Leu?Ile?Ala?His?Glu?Leu?Ser

295 300 305

cac?cag?tgg?ttt?ggc?aac?tca?ctc?ggc?ctc?gcc?caa?tgg?aac?gac?atc 1075

His?Gln?Trp?Phe?Gly?Asn?Ser?Leu?Gly?Leu?Ala?Gln?Trp?Asn?Asp?Ile

310 315 320 325

tgg?ctc?aac?gaa?ggc?ttc?gcc?tgt?tac?gcg?gaa?tgg?ctc?tgg?ttt?gag 1123

Trp?Leu?Asn?Glu?Gly?Phe?Ala?Cys?Tyr?Ala?Glu?Trp?Leu?Trp?Phe?Glu

330 335 340

gca?gct?gga?gtt?aag?tcg?gct?gcg?gaa?agt?gcg?ttg?gaa?ttc?tat?cga 1171

Ala?Ala?Gly?Val?Lys?Ser?Ala?Ala?Glu?Ser?Ala?Leu?Glu?Phe?Tyr?Arg

345 350 355

ggc?ctg?gag?gcg?ctg?ccg?aag?gat?att?ttg?ctg?gcc?aac?ccc?ggc?gcg 1219

Gly?Leu?Glu?Ala?Leu?Pro?Lys?Asp?Ile?Leu?Leu?Ala?Asn?Pro?Gly?Ala

360 365 370

aag?gat?atg?ttc?gac?gac?cgc?gtc?tac?aag?cgc?ggc?gct?ctg?act?gtc 1267

Lys?Asp?Met?Phe?Asp?Asp?Arg?Val?Tyr?Lys?Arg?Gly?Ala?Leu?Thr?Val

375 380 385

cat?gca?ttg?cgg?gaa?ttg?ctt?ggc?gat?gat?gca?ttc?ttc?aaa?gct?gtg 1315

His?Ala?Leu?Arg?Glu?Leu?Leu?Gly?Asp?Asp?Ala?Phe?Phe?Lys?Ala?Val

390 395 400 405

cgc?tcc?tac?gtt?gcc?gaa?ggc?cga?cac?gga?ctc?gtt?gaa?ccc?cgc?gac 1363

Arg?Ser?Tyr?Val?Ala?Glu?Gly?Arg?His?Gly?Leu?Val?Glu?Pro?Arg?Asp

410 415 420

ctg?aaa?cga?cac?ctc?tac?gca?gtc?tcc?aca?gac?cac?gca?gct?tta?gat 1411

Leu?Lys?Arg?His?Leu?Tyr?Ala?Val?Ser?Thr?Asp?His?Ala?Ala?Leu?Asp

425 430 435

gca?gtg?tgg?cag?tcc?tgg?ctt?cgc?gat?ctg?gag?ttg?ccg?gag?ttt?cct 1459

Ala?Val?Trp?Gln?Ser?Trp?Leu?Arg?Asp?Leu?Glu?Leu?Pro?Glu?Phe?Pro

440 445 450

tct?ggt?ggt?ttg?gac?tagtgcgcta?tctgacgctg?gcc 1497

Ser?Gly?Gly?Leu?Asp

455

<210>124

<211>458

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>124

Met?Arg?Arg?Leu?Arg?Ser?Thr?Pro?Val?Pro?Gly?Thr?Arg?Asp?Ser?Tyr

1 5 10 15

Thr?Gly?Ile?Asp?Phe?Asn?Leu?Gly?Phe?His?Ile?Arg?Arg?Tyr?Glu?Leu

20 25 30

Asp?Leu?Thr?Tyr?Arg?Val?Ala?Pro?Asn?Leu?Leu?Met?Gly?Thr?Ala?Thr

35 40 45

Leu?His?Met?Asp?Asn?Tyr?Arg?Ala?Leu?Asp?Ala?Leu?Thr?Leu?Asp?Leu

50 55 60

Gly?Gly?Ser?Leu?Arg?Val?Glu?Lys?Val?Thr?Ala?Lys?Gly?Thr?Ala?Gly

65 70 75 80

Thr?His?Ile?Gln?Val?Ala?Arg?Phe?Arg?His?Ala?Gly?Arg?Lys?Leu?Arg

85 90 95

Ile?Thr?Phe?Arg?Asn?Gln?Ile?Pro?Val?Asp?Gln?Glu?Phe?Ser?Leu?Thr

100 105 110

Ile?Arg?Tyr?Arg?Gly?Asn?Pro?Arg?Pro?Leu?Arg?Ser?Glu?Trp?Gly?Met

115 120 125

Ile?Gly?Trp?Glu?Glu?Leu?Asp?Asn?Gly?Ala?Leu?Val?Ala?Ala?Gln?Pro

130 135 140

Asn?Gly?Ala?Pro?Ser?Trp?Phe?Pro?Cys?Asp?Asp?Thr?Pro?Asp?Glu?Lys

145 150 155 160

Ala?Leu?Phe?Asp?Val?His?Phe?His?Thr?Asp?Asn?Gly?Tyr?Ala?Ala?Ile

165 170 175

Ile?Thr?Gly?Asp?Leu?Ile?Ser?Lys?His?Val?Ser?Gly?Ser?Met?Thr?Thr

180 185 190

Trp?His?Tyr?Gln?Ser?Arg?Glu?Pro?Met?Ala?Thr?Tyr?Leu?Ala?Ala?Val

195 200 205

His?Val?Gly?Glu?Tyr?Asp?Thr?Val?Ser?Leu?Gly?Val?Ser?Glu?Ser?Gly

210 215 220

Val?Val?Val?Glu?Ala?Tyr?Val?Pro?Val?Gly?Asp?Ala?Ala?Leu?Arg?Ala

225 230 235 240

Arg?Ile?Leu?Glu?Asp?Phe?Ala?Lys?Gln?Val?Asp?Met?Leu?Asp?Ala?Tyr

245 250 255

Glu?Lys?Leu?Phe?Gly?Pro?Tyr?Pro?Phe?Arg?Ser?Tyr?Arg?Val?Val?Ile

260 265 270

Thr?Glu?Asp?Glu?Leu?Glu?Ile?Pro?Leu?Glu?Ala?Gln?Gly?Leu?Ser?Ser

275 280 285

Phe?Gly?Ala?Asn?His?Ala?Thr?Gly?Glu?Gly?Thr?Trp?Glu?Arg?Leu?Ile

290 295 300

Ala?His?Glu?Leu?Ser?His?Gln?Trp?Phe?Gly?Asn?Ser?Leu?Gly?Leu?Ala

305 310 315 320

Gln?Trp?Asn?Asp?Ile?Trp?Leu?Asn?Glu?Gly?Phe?Ala?Cys?Tyr?Ala?Glu

325 330 335

Trp?Leu?Trp?Phe?Glu?Ala?Ala?Gly?Val?Lys?Ser?Ala?Ala?Glu?Ser?Ala

340 345 350

Leu?Glu?Phe?Tyr?Arg?Gly?Leu?Glu?Ala?Leu?Pro?Lys?Asp?Ile?Leu?Leu

355 360 365

Ala?Asn?Pro?Gly?Ala?Lys?Asp?Met?Phe?Asp?Asp?Arg?Val?Tyr?Lys?Arg

370 375 380

Gly?Ala?Leu?Thr?Val?His?Ala?Leu?Arg?Glu?Leu?Leu?Gly?Asp?Asp?Ala

385 390 395 400

Phe?Phe?Lys?Ala?Val?Arg?Ser?Tyr?Val?Ala?Glu?Gly?Arg?His?Gly?Leu

405 410 415

Val?Glu?Pro?Arg?Asp?Leu?Lys?Arg?His?Leu?Tyr?Ala?Val?Ser?Thr?Asp

420 425 430

His?Ala?Ala?Leu?Asp?Ala?Val?Trp?Gln?Ser?Trp?Leu?Arg?Asp?Leu?Glu

435 440 445

Leu?Pro?Glu?Phe?Pro?Ser?Gly?Gly?Leu?Asp

450 455

<210>125

<211>906

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CPS

<222>(101)..(883)

<223>RXN00621

<400>125

aaatgaatcc?gggtttttca?gtttcggggt?gcaaatcaga?atgtcgccaa?tggcgaacac?60

acgagcgtgc?agaagatgtg?cgtgactaag?atcgggggct?atg?tct?gaa?cgc?cta 115

Met?Ser?Glu?Arg?Leu

1 5

aac?gct?ccg?caa?gca?cca?atc?cat?ccc?atc?acc?cga?acc?cac?cac?ggt 163

Asn?Ala?Pro?Gln?Ala?Pro?Ile?His?Pro?Ile?Thr?Arg?Thr?His?His?Gly

10 15 20

att?gat?ttc?gta?gac?aac?tat?gaa?tgg?ctg?agg?gat?aaa?gaa?tcc?caa 211

Ile?Asp?Phe?Val?Asp?Asn?Tyr?Glu?Trp?Leu?Arg?Asp?Lys?Glu?Ser?Gln

25 30 35

gaa?acc?ttg?gac?tac?ctg?gag?gcg?gag?aat?gcg?ttc?acc?aag?cag?gag 259

Glu?Thr?Leu?Asp?Tyr?Leu?Glu?Ala?Glu?Asn?Ala?Phe?Thr?Lys?Gln?Glu

40 45 50

act?gaa?cag?cta?gcc?aca?ctg?cgg?gac?aac?atc?tat?gaa?gag?att?aag 307

Thr?Glu?Gln?Leu?Ala?Thr?Leu?Arg?Asp?Asn?Ile?Tyr?Glu?Glu?Ile?Lys

55 60 65

tca?cgc?gtt?aaa?gaa?acc?gac?atg?tcc?atc?cca?gtg?cgt?gcc?gga?aag 355

Ser?Arg?Val?Lys?Glu?Thr?Asp?Met?Ser?Ile?Pro?Val?Arg?Ala?Gly?Lys

70 75 80 85

cac?tgg?tat?tac?tct?cgc?act?gaa?gaa?ggc?aag?agc?tac?ggc?tat?tcc 403

His?Trp?Tyr?Tyr?Ser?Arg?Thr?Glu?Glu?Gly?Lys?Ser?Tyr?Gly?Tyr?Ser

90 95 100

tgc?cgc?att?cca?gtg?act?gaa?ggg?tcg?gat?gca?tgg?acc?cct?cct?gtt 451

Cys?Arg?Ile?Pro?Val?Thr?Glu?Gly?Ser?Asp?Ala?Trp?Thr?Pro?Pro?Val

105 110 115

atc?cct?gag?ggt?gag?cca?gcg?cag?ggt?gaa?acc?atc?atc?atg?gat?gcc 499

Ile?Pro?Glu?Gly?Glu?Pro?Ala?Gln?Gly?Glu?Thr?Ile?Ile?Met?Asp?Ala

120 125 130

aac?gag?ttg?gca?gaa?ggc?cac?gaa?ttc?ttc?tcc?atg?ggt?gca?tca?tct 547

Asn?Glu?Leu?Ala?Glu?Gly?His?Glu?Phe?Phe?Ser?Met?Gly?Ala?Ser?Ser

135 140 145

gtc?acc?acc?tct?ggc?cgc?tac?ctt?gcg?tat?tcc?acc?gat?gtc?acg?ggc 595

Val?Thr?Thr?Ser?Gly?Arg?Tyr?Leu?Ala?Tyr?Ser?Thr?Asp?Val?Thr?Gly

150 155 160 165

gaa?gag?cgc?ttt?acg?ttg?cgc?atc?aag?gat?cta?gaa?act?ggc?gag?ctg 643

Glu?Glu?Arg?Phe?Thr?Leu?Arg?Ile?Lys?Asp?Leu?Glu?Thr?Gly?Glu?Leu

170 175 180

ctt?cct?gat?acc?ctg?act?ggc?att?ttc?tac?ggt?gct?act?tgg?gtg?ggg 691

Leu?Pro?Asp?Thr?Leu?Thr?Gly?Ile?Phe?Tyr?Gly?Ala?Thr?Trp?Val?Gly

185 190 195

gag?gag?tac?ctc?ttt?tac?cag?cgc?gtt?gat?gat?gcg?tgg?cgt?cca?gat 739

Glu?Glu?Tyr?Leu?Phe?Tyr?Gln?Arg?Val?Asp?Asp?Ala?Trp?Arg?Pro?Asp

200 205 210

act?gtg?tgg?cgc?cac?aag?gtg?ggt?acc?ccg?gtt?gaa?gaa?gac?gtg?ttg 787

Thr?Val?Trp?Arg?His?Lys?Val?Gly?Thr?Pro?Val?Glu?Glu?Asp?Val?Leu

215 220 225

gtg?tac?cac?gag?cct?gat?gaa?cgt?tat?tcc?acc?tgg?gtg?ggc?acc?act 835

Val?Tyr?His?Glu?Pro?Asp?Glu?Arg?Tyr?Ser?Thr?Trp?Val?Gly?Thr?Thr

230 235 240 245

cgt?tca?gaa?aaa?gtt?cat?cct?ttt?tgg?ttg?cgc?ctc?caa?gat?cac?ctc 883

Arg?Ser?Glu?Lys?Val?His?Pro?Phe?Trp?Leu?Arg?Leu?Gln?Asp?His?Leu

250 255 260

tgaagtacgc?gtgcttcctt?tcg 906

<210>126

<211>261

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>126

Met?Ser?Glu?Arg?Leu?Asn?Ala?Pro?Gln?Ala?Pro?Ile?His?Pro?Ile?Thr

1 5 10

Arg?Thr?His?His?Gly?Ile?Asp?Phe?Val?Asp?Asn?Tyr?Glu?Trp?Leu?Arg

20 25 30

Asp?Lys?Glu?Ser?Gln?Glu?Thr?Leu?Asp?Tyr?Leu?Glu?Ala?Glu?Asn?Ala

35 40 45

Phe?Thr?Lys?Gln?Glu?Thr?Glu?Gln?Leu?Ala?Thr?Leu?Arg?Asp?Asn?Ile

50 55 60

Tyr?Glu?Glu?Ile?Lys?Ser?Arg?Val?Lys?Glu?Thr?Asp?Met?Ser?Ile?Pro

65 70 75 80

Val?Arg?Ala?Gly?Lys?His?Trp?Tyr?Tyr?Ser?Arg?Thr?Glu?Glu?Gly?Lys

85 90 95

Ser?Tyr?Gly?Tyr?Ser?Cys?Arg?Ile?Pro?Val?Thr?Glu?Gly?Ser?Asp?Ala

100 105 110

Trp?Thr?Pro?Pro?Val?Ile?Pro?Glu?Gly?Glu?Pro?Ala?Gln?Gly?Glu?Thr

115 120 125

Ile?Ile?Met?Asp?Ala?Asn?Glu?Leu?Ala?Glu?Gly?His?Glu?Phe?Phe?Ser

130 135 140

Met?Gly?Ala?Ser?Ser?Val?Thr?Thr?Ser?Gly?Arg?Tyr?Leu?Ala?Tyr?Ser

145 150 155 160

Thr?Asp?Val?Thr?Gly?Glu?Glu?Arg?Phe?Thr?Leu?Arg?Ile?Lys?Asp?Leu

165 170 175

Glu?Thr?Gly?Glu?Leu?Leu?Pro?Asp?Thr?Leu?Thr?Gly?Ile?Phe?Tyr?Gly

180 185 190

Ala?Thr?Trp?Val?Gly?Glu?Glu?Tyr?Leu?Phe?Tyr?Gln?Arg?Val?Asp?Asp

195 200 205

Ala?Trp?Arg?Pro?Asp?Thr?Val?Trp?Arg?His?Lys?Val?Gly?Thr?Pro?Val

210 215 220

Glu?Glu?Asp?Val?Leu?Val?Tyr?His?Glu?Pro?Asp?Glu?Arg?Tyr?Ser?Thr

225 230 235 240

Trp?Val?Gly?Thr?Thr?Arg?Ser?Glu?Lys?Val?His?Pro?Phe?Trp?Leu?Arg

245 250 255

Leu?Gln?Asp?His?Leu

260

<210>127

<211>906

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(883)

<223>FRXA00621

<400>127

aaatgaatcc?gggtttttca?gtttcggggt?gcaaatcaga?atgtcgccaa?tggcgaacac?60

acgagcgtgc?agaagatgtg?cgtgactaag?atcgggggct?atg?tct?gaa?cgc?cta 115

Met?Ser?Glu?Arg?Leu

1 5

aac?gct?ccg?caa?gca?cca?atc?cat?ccc?atc?acc?cga?acc?cac?cac?ggt 163

Asn?Ala?Pro?Gln?Ala?Pro?Ile?His?Pro?Ile?Thr?Arg?Thr?His?His?Gly

10 15 20

att?gat?ttc?gta?gac?aac?tat?gaa?tgg?ctg?agg?gat?aaa?gaa?tcc?caa 211

Ile?Asp?Phe?Val?Asp?Asn?Tyr?Glu?Trp?Leu?Arg?Asp?Lys?Glu?Ser?Gln

25 30 35

gaa?acc?ttg?gac?tac?ctg?gag?gcg?gag?aat?gcg?ttc?acc?aag?cag?gag 259

Glu?Thr?Leu?Asp?Tyr?Leu?Glu?Ala?Glu?Asn?Ala?Phe?Thr?Lys?Gln?Glu

40 45 50

act?gaa?cag?cta?gcc?aca?ctg?cgg?gac?aac?atc?tat?gaa?gag?att?aag 307

Thr?Glu?Gln?Leu?Ala?Thr?Leu?Arg?Asp?Asn?Ile?Tyr?Glu?Glu?Ile?Lys

55 60 65

tca?cgc?gtt?aaa?gaa?acc?gac?atg?tcc?atc?cca?gtg?cgt?gcc?gga?aag 355

Ser?Arg?Val?Lys?Glu?Thr?Asp?Met?Ser?Ile?Pro?Val?Arg?Ala?Gly?Lys

70 75 80 85

cac?tgg?tat?tac?tct?cgc?act?gaa?gaa?ggc?aag?agc?tac?ggc?tat?tcc 403

His?Trp?Tyr?Tyr?Ser?Arg?Thr?Glu?Glu?Gly?Lys?Ser?Tyr?Gly?Tyr?Ser

90 95 100

tgc?cgc?att?cca?gtg?act?gaa?ggg?tcg?gat?gca?tgg?acc?cct?cct?gtt 451

Cys?Arg?Ile?Pro?Val?Thr?Glu?Gly?Ser?Asp?Ala?Trp?Thr?Pro?Pro?Val

105 110 115

atc?cct?gag?ggt?gag?cca?gcg?cag?ggt?gaa?acc?atc?atc?atg?gat?gcc 499

Ile?Pro?Glu?Gly?Glu?Pro?Ala?Gln?Gly?Glu?Thr?Ile?Ile?Met?Asp?Ala

120 125 130

aac?gag?ttg?gca?gaa?ggc?cac?gaa?ttc?ttc?tcc?atg?ggt?gca?tca?tct 547

Asn?Glu?Leu?Ala?Glu?Gly?His?Glu?Phe?Phe?Ser?Met?Gly?Ala?Ser?Ser

135 140 145

gtc?acc?acc?tct?ggc?cgc?tac?ctt?gcg?tat?tcc?acc?gat?gtc?acg?ggc 595

Val?Thr?Thr?Ser?Gly?Arg?Tyr?Leu?Ala?Tyr?Ser?Thr?Asp?Val?Thr?Gly

150 155 160 165

gaa?gag?cgc?ttt?acg?ttg?cgc?atc?aag?gat?cta?gaa?act?ggc?gag?ctg 643

Glu?Glu?Arg?Phe?Thr?Leu?Arg?Ile?Lys?Asp?Leu?Glu?Thr?Gly?Glu?Leu

170v 175 180

ctt?cct?gat?acc?ctg?act?ggc?att?ttc?tac?ggt?gct?act?tgg?gtg?ggg 691

Leu?Pro?Asp?Thr?Leu?Thr?Gly?Ile?Phe?Tyr?Gly?Ala?Thr?Trp?Val?Gly

185 190 195

gag?gag?tac?ctc?ttt?tac?cag?cgc?gtt?gat?gat?gcg?tgg?cgt?cca?gat 739

Glu?Glu?Tyr?Leu?Phe?Tyr?Gln?Arg?Val?Asp?Asp?Ala?Trp?Arg?Pro?Asp

200 205 210

act?gtg?tgg?cgc?cac?aag?gtg?ggt?acc?ccg?gtt?gaa?gaa?gac?gtg?ttg 787

Thr?Val?Trp?Arg?His?Lys?Val?Gly?Thr?Pro?Val?Glu?Glu?Asp?Val?Leu

215 220 225

gtg?tac?cac?gag?cct?gat?gaa?cgt?tat?tcc?acc?tgg?gtg?ggc?acc?act 835

Val?Tyr?His?Glu?Pro?Asp?Glu?Arg?Tyr?Ser?Thr?Trp?Val?Gly?Thr?Thr

230 235 240 245

cgt?tca?gaa?aaa?gtt?cat?cct?ttt?tgg?ttg?cgc?ctc?caa?gat?cac?ctc 883

Arg?Ser?Glu?Lys?Val?His?Pro?Phe?Trp?Leu?Arg?Leu?Gln?Asp?His?Leu

250 255 260

tgaagtacgc?gtgcttcctt?tcg 906

<210>128

<211>261

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>128

Met?Ser?Glu?Arg?Leu?Asn?Ala?Pro?Gln?Ala?Pro?Ile?His?Pro?Ile?Thr

1 5 10 15

Arg?Thr?His?His?Gly?Ile?Asp?Phe?Val?Asp?Asn?Tyr?Glu?Trp?Leu?Arg

20 25 30

Asp?Lys?Glu?Ser?Gln?Glu?Thr?Leu?Asp?Tyr?Leu?Glu?Ala?Glu?Asn?Ala

35 40 45

Phe?Thr?Lys?Gln?Glu?Thr?Glu?Gln?Leu?Ala?Thr?Leu?Arg?Asp?Asn?Ile

50 55 60

Tyr?Glu?Glu?Ile?Lys?Ser?Arg?Val?Lys?Glu?Thr?Asp?Met?Ser?Ile?Pro

65 70 75 80

Val?Arg?Ala?Gly?Lys?His?Trp?Tyr?Tyr?Ser?Arg?Thr?Glu?Glu?Gly?Lys

85 90 95

Ser?Tyr?Gly?Tyr?Ser?Cys?Arg?Ile?Pro?Val?Thr?Glu?Gly?Ser?Asp?Ala

100 105 110

Trp?Thr?Pro?Pro?Val?Ile?Pro?Glu?Gly?Glu?Pro?Ala?Gln?Gly?Glu?Thr

115 120 125

Ile?Ile?Met?Asp?Ala?Asn?Glu?Leu?Ala?Glu?Gly?His?Glu?Phe?Phe?Ser

130 135 140

Met?Gly?Ala?Ser?Ser?Val?Thr?Thr?Ser?Gly?Arg?Tyr?Leu?Ala?Tyr?Ser

145 150 155 160

Thr?Asp?Val?Thr?Gly?Glu?Glu?Arg?Phe?Thr?Leu?Arg?Ile?Lys?Asp?Leu

165 170 175

Glu?Thr?Gly?Glu?Leu?Leu?Pro?Asp?Thr?Leu?Thr?Gly?Ile?Phe?Tyr?Gly

180 185 190

Ala?Thr?Trp?Val?Gly?Glu?Glu?Tyr?Leu?Phe?Tyr?Gln?Arg?Val?Asp?Asp

195 200 205

Ala?Trp?Arg?Pro?Asp?Thr?Val?Trp?Arg?His?Lys?Val?Gly?Thr?Pro?Val

210 215 220

Glu?Glu?Asp?Val?Leu?Val?Tyr?His?Glu?Pro?Asp?Glu?Arg?Tyr?Ser?Thr

225 230 235 240

Trp?Val?Gly?Thr?Thr?Arg?Ser?Glu?Lys?Val?His?Pro?Phe?Trp?Leu?Arg

245 250 255

Leu?Gln?Asp?His?Leu

260

<210>129

<211>1539

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1516)

<223>RXN00622

<400>129

ttttaccagc?gcgttgatga?tgcgtggcgt?ccagatactg?tgtggcgcca?caaggtgggt?60

accccggttg?aagaagacgt?gttggtgtac?cacgagcctg?atg?aac?gtt?att?cca 115

Met?Asn?Val?Ile?Pro

1 5

cct?ggg?tgg?gca?cca?ctc?gtt?cag?aaa?aag?ttc?atc?ctt?ttt?ggt?tgc 163

Pro?Gly?Trp?Ala?Pro?Leu?Val?Gln?Lys?Lys?Phe?Ile?Leu?Phe?Gly?Cys

10 15 20

gcc?tcc?aag?atc?acc?tct?gaa?gta?cgc?gtg?ctt?cct?ttc?gac?cag?cca 211

Ala?Ser?Lys?Ile?Thr?Ser?Glu?Val?Arg?Val?Leu?Pro?Phe?Asp?Gln?Pro

25 30 35

gag?ggc?acc?cct?gag?gtg?ctg?att?ccg?cgc?gcg?gag?ggt?gtg?gaa?tac 259

Glu?Gly?Thr?Pro?Glu?Val?Leu?Ile?Pro?Arg?Ala?Glu?Gly?Val?Glu?Tyr

40 45 50

gac?gtc?gat?cat?gca?gtc?gta?gac?ggc?tcc?gat?att?tgg?ttg?gtc?aca 307

Asp?Val?Asp?His?Ala?Val?Val?Asp?Gly?Ser?Asp?Ile?Trp?Leu?Val?Thr

55 60 65

cac?aac?gcc?gag?ggc?ccg?aac?ttt?tcg?gtg?ggg?tgg?gct?ggc?gtc?gac 355

His?Asn?Ala?Glu?Gly?Pro?Asn?Phe?Ser?Val?Gly?Trp?Ala?Gly?Val?Asp

70 75 80 85

aag?ctc?aat?tct?ttg?gac?gcg?ctg?gcg?cca?ctc?gtc?gcg?cac?aag?gat 403

Lys?Leu?Asn?Ser?Leu?Asp?Ala?Leu?Ala?Pro?Leu?Val?Ala?His?Lys?Asp

90 95 100

gac?gtg?cgc?att?gag?ggt?gtc?gat?acc?tac?cgc?gat?ttc?atc?atc?ctg 451

Asp?Val?Arg?Ile?Glu?Gly?Val?Asp?Thr?Tyr?Arg?Asp?Phe?Ile?Ile?Leu

105 110 115

ggc?tac?agg?tcc?ggc?gcg?atc?ggc?cag?gtc?gcg?atc?atg?aag?ctt?atc 499

Gly?Tyr?Arg?Ser?Gly?Ala?Ile?Gly?Gln?Val?Ala?Ile?Met?Lys?Leu?Ile

120 125 130

gac?gga?acc?ttc?ggc?gat?ttc?caa?cag?ctg?gaa?ttt?gac?gag?gaa?atc 547

Asp?Gly?Thr?Phe?Gly?Asp?Phe?Gln?Gln?Leu?Glu?Phe?Asp?Glu?Glu?Ile

135 140 145

tac?acc?gtc?gca?tcg?ggc?gga?aac?cca?gaa?tgg?gac?gcc?ccc?gtc?att 595

Tyr?Thr?Val?Ala?Ser?Gly?Gly?Asn?Pro?Glu?Trp?Asp?Ala?Pro?Val?Ile

150 155 160 165

cgc?ctt?tct?tac?gga?tca?ttc?acc?acc?ccg?gcg?cag?ctg?ttt?aac?tac 643

Arg?Leu?Ser?Tyr?Gly?Ser?Phe?Thr?Thr?Pro?Ala?Gln?Leu?Phe?Asn?Tyr

170 175 180

tgg?att?gaa?tcc?ggc?gaa?cgc?acg?ctg?ctg?aag?cag?cag?gaa?gtg?ctc 691

Trp?Ile?Glu?Ser?Gly?Glu?Arg?Thr?Leu?Leu?Lys?Gln?Gln?Glu?Val?Leu

185 190 195

ggc?gga?tac?aag?ccg?tca?gac?tat?gtg?gcc?tcc?cga?ttg?tgg?gtc?act 739

Gly?Gly?Tyr?Lys?Pro?Ser?Asp?Tyr?Val?Ala?Ser?Arg?Leu?Trp?Val?Thr

200 205 210

gcg?aaa?gat?ggc?gcg?cag?att?cca?gtg?tcc?ttg?gtg?cac?cgc?acc?gac 787

Ala?Lys?Asp?Gly?Ala?Gln?Ile?Pro?Val?Ser?Leu?Val?His?Arg?Thr?Asp

215 220 225

ctg?gat?gta?tcc?aag?ccc?aac?ccc?acg?ttg?ctc?tac?ggc?tat?ggt?tcc 835

Leu?Asp?Val?Ser?Lys?Pro?Asn?Pro?Thr?Leu?Leu?Tyr?Gly?Tyr?Gly?Ser

230 235 240 245

tac?gaa?tca?tcc?att?gat?cca?ggc?ttc?tct?atc?gcg?cgt?ttg?tca?ctg 883

Tyr?Glu?Ser?Ser?Ile?Asp?Pro?Gly?Phe?Ser?Ile?Ala?Arg?Leu?Ser?Leu

250 255 260

atg?gat?cgt?ggc?atg?att?ttt?gcg?att?gcc?cac?gtt?cgt?ggc?ggt?ggc 931

Met?Asp?Arg?Gly?Met?Ile?Phe?Ala?Ile?Ala?His?Val?Arg?Gly?Gly?Gly

265 270 275

gaa?atg?ggt?cgt?ggc?tgg?tac?gac?aac?ggc?aaa?acc?acc?acg?aag?aaa 979

Glu?Met?Gly?Arg?Gly?Trp?Tyr?Asp?Asn?Gly?Lys?Thr?Thr?Thr?Lys?Lys

280 285 290

aac?acc?ttc?acc?gac?ttc?att?gat?gtt?gcc?gac?gcc?ctc?atc?gag?cag 1027

Asn?Thr?Phe?Thr?Asp?Phe?Ile?Asp?Val?Ala?Asp?Ala?Leu?Ile?Glu?Gln

295 300 305

aag?att?tct?gcc?cct?gaa?atg?ctg?gtt?gca?gaa?ggc?ggc?tca?gct?ggt 1075

Lys?Ile?Ser?Ala?Pro?Glu?Met?Leu?Val?Ala?Glu?Gly?Gly?Ser?Ala?Gly

310 315 320 325

ggc?atg?ctc?atg?ggc?gcc?att?gcc?aac?atg?gcc?ggt?gac?cgc?ttc?aag 1123

Gly?Met?Leu?Met?Gly?Ala?Ile?Ala?Asn?Met?Ala?Gly?Asp?Arg?Phe?Lys

330 335 340

gcg?atc?gaa?gcc?aac?gtg?cca?ttc?gtc?gat?ccg?ctg?acc?tct?atg?ctc 1171

Ala?Ile?Glu?Ala?Asn?Val?Pro?Phe?Val?Asp?Pro?Leu?Thr?Ser?Met?Leu

345 350 355

atg?ccg?gaa?ctg?cca?ctg?acg?gtt?atc?gaa?tgg?gat?gag?tgg?ggc?gat 1219

Met?Pro?Glu?Leu?Pro?Leu?Thr?Val?Ile?Glu?Trp?Asp?Glu?Trp?Gly?Asp

360 365 370

cca?ctc?cac?gat?aag?gac?gtc?tat?gaa?tac?atg?gcg?tcg?tat?gcc?cca 1267

Pro?Leu?His?Asp?Lys?Asp?Val?Tyr?Glu?Tyr?Met?Ala?Ser?Tyr?Ala?Pro

375 380 385

tat?gaa?aac?atc?gag?gca?aag?aac?tac?ccc?aat?atc?ttg?gcc?gta?aca 1315

Tyr?Glu?Asn?Ile?Glu?Ala?Lys?Asn?Tyr?Pro?Asn?Ile?Leu?Ala?Val?Thr

390 395 400 405

tcg?ctc?aac?gac?acc?cga?gtg?ttg?tac?gtc?gaa?cca?gcc?aaa?tgg?gta 1363

Ser?Leu?Asn?Asp?Thr?Arg?Val?Leu?Tyr?Val?Glu?Pro?Ala?Lys?Trp?Val

410 415 420

gcg?cag?ctt?cgg?gcg?act?gca?acc?ggt?gga?gaa?ttc?ctt?ctg?aaa?act 1411

Ala?Gln?Leu?Arg?Ala?Thr?Ala?Thr?Gly?Gly?Glu?Phe?Leu?Leu?Lys?Thr

425 430 435

gaa?atg?gtt?gcc?gga?cac?ggc?ggt?gtg?tca?gga?cgc?tac?gaa?aag?tgg 1459

Glu?Met?Val?Ala?Gly?His?Gly?Gly?Val?Ser?Gly?Arg?Tyr?Glu?Lys?Trp

440 445 450

cgt?gag?act?gca?ttt?gag?tac?ggc?tgg?ttg?atc?aac?caa?gca?acc?ggt 1507

Arg?Glu?Thr?Ala?Phe?Glu?Tyr?Gly?Trp?Leu?Ile?Asn?Gln?Ala?Thr?Gly

455 460 465

gtg?acc?gaa?taaaacttgt?tcgactagcg?aac 1539

Val?Thr?Glu

470

<210>130

<211>472

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>130

Met?Asn?Val?Ile?Pro?Pro?Gly?Trp?Ala?Pro?Leu?Val?Gln?Lys?Lys?Phe

1 5 10 15

Ile?Leu?Phe?Gly?Cys?Ala?Ser?Lys?Ile?Thr?Ser?Glu?Val?Arg?Val?Leu

20 25 30

Pro?Phe?Asp?Gln?Pro?Glu?Gly?Thr?Pro?Glu?Val?Leu?Ile?Pro?Arg?Ala

35 40 45

Glu?Gly?Val?Glu?Tyr?Asp?Val?Asp?His?Ala?Val?Val?Asp?Gly?Ser?Asp

50 55 60

Ile?Trp?Leu?Val?Thr?His?Asn?Ala?Glu?Gly?Pro?Asn?Phe?Ser?Val?Gly

65 70 75 80

Trp?Ala?Gly?Val?Asp?Lys?Leu?Asn?Ser?Leu?Asp?Ala?Leu?Ala?Pro?Leu

85 90 95

Val?Ala?His?Lys?Asp?Asp?Val?Arg?Ile?Glu?Gly?Val?Asp?Thr?Tyr?Arg

100 105 110

Asp?Phe?Ile?Ile?Leu?Gly?Tyr?Arg?Ser?Gly?Ala?Ile?Gly?Gln?Val?Ala

115 120 125

Ile?Met?Lys?Leu?Ile?Asp?Gly?Thr?Phe?Gly?Asp?Phe?Gln?Gln?Leu?Glu

130 135 140

Phe?Asp?Glu?Glu?Ile?Tyr?Thr?Val?Ala?Ser?Gly?Gly?Asn?Pro?Glu?Trp

145 150 155 160

Asp?Ala?Pro?Val?Ile?Arg?Leu?Ser?Tyr?Gly?Ser?Phe?Thr?Thr?Pro?Ala

165 170 175

Gln?Leu?Phe?Asn?Tyr?Trp?Ile?Glu?Ser?Gly?Glu?Arg?Thr?Leu?Leu?Lys

180 185 190

Gln?Gln?Glu?Val?Leu?Gly?Gly?Tyr?Lys?Pro?Ser?Asp?Tyr?Val?Ala?Ser

195 200 205

Arg?Leu?Trp?Val?Thr?Ala?Lys?Asp?Gly?Ala?Gln?Ile?Pro?Val?Ser?Leu

210 215 220

Val?His?Arg?Thr?Asp?Leu?Asp?Val?Ser?Lys?Pro?Asn?Pro?Thr?Leu?Leu

225 230 235 240

Tyr?Gly?Tyr?Gly?Ser?Tyr?Glu?Ser?Ser?Ile?Asp?Pro?Gly?Phe?Ser?Ile

245 250 255

Ala?Arg?Leu?Ser?Leu?Met?Asp?Arg?Gly?Met?Ile?Phe?Ala?Ile?Ala?His

260 265 270

Val?Arg?Gly?Gly?Gly?Glu?Met?Gly?Arg?Gly?Trp?Tyr?Asp?Asn?Gly?Lys

275 280 285

Thr?Thr?Thr?Lys?Lys?Asn?Thr?Phe?Thr?Asp?Phe?Ile?Asp?Val?Ala?Asp

290 295 300

Ala?Leu?Ile?Glu?Gln?Lys?Ile?Ser?Ala?Pro?Glu?Met?Leu?Val?Ala?Glu

305 310 315 320

Gly?Gly?Ser?Ala?Gly?Gly?Met?Leu?Met?Gly?Ala?Ile?Ala?Asn?Met?Ala

325 330 335

Gly?Asp?Arg?Phe?Lys?Ala?Ile?Glu?Ala?Asn?Val?Pro?Phe?Val?Asp?Pro

340 345 350

Leu?Thr?Ser?Met?Leu?Met?Pro?Glu?Leu?Pro?Leu?Thr?Val?Ile?Glu?Trp

355 360 365

Asp?Glu?Trp?Gly?Asp?Pro?Leu?His?Asp?Lys?Asp?Val?Tyr?Glu?Tyr?Met

370 375 380

Ala?Ser?Tyr?Ala?Pro?Tyr?Glu?Asn?Ile?Glu?Ala?Lys?Asn?Tyr?Pro?Asn

385 390 395 400

Ile?Leu?Ala?Val?Thr?Ser?Leu?Asn?Asp?Thr?Arg?Val?Leu?Tyr?Val?Glu

405 410 415

Pro?Ala?Lys?Trp?Val?Ala?Gln?Leu?Arg?Ala?Thr?Ala?Thr?Gly?Gly?Glu

420 425 430

Phe?Leu?Leu?Lys?Thr?Glu?Met?Val?Ala?Gly?His?Gly?Gly?Val?Ser?Gly

435 440 445

Arg?Tyr?Glu?Lys?Trp?Arg?Glu?Thr?Ala?Phe?Glu?Tyr?Gly?Trp?Leu?Ile

450 455 460

Asn?Gln?Ala?Thr?Gly?Val?Thr?Glu

465 470

<210>131

<211>1539

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1516)

<223>FRXA00622

<400>131

ttttaccagc?gcgttgatga?tgcgtggcgt?ccagatactg?tgtggcgcca?caaggtgggt?60

accccggttg?aagaagacgt?gttggtgtac?cacgagcctg?atg?aac?gtt?att?cca 115

Met?Asn?Val?Ile?Pro

1 5

cct?ggg?tgg?gca?cca?ctc?gtt?cag?aaa?aag?ttc?atc?ctt?ttt?ggt?tgc 163

Pro?Gly?Trp?Ala?Pro?Leu?Val?Gln?Lys?Lys?Phe?Ile?Leu?Phe?Gly?Cys

10 15 20

gcc?tcc?aag?atc?acc?tct?gaa?gta?cgc?gtg?ctt?cct?ttc?gac?cag?cca 211

Ala?Ser?Lys?Ile?Thr?Ser?Glu?Val?Arg?Val?Leu?Pro?Phe?Asp?Gln?Pro

25 30 35

gag?ggc?acc?cct?gag?gtg?ctg?att?ccg?cgc?gcg?gag?ggt?gtg?gaa?tac 259

Glu?Gly?Thr?Pro?Glu?Val?Leu?Ile?Pro?Arg?Ala?Glu?Gly?Val?Glu?Tyr

40 45 50

gac?gtc?gat?cat?gca?gtc?gta?gac?ggc?tcc?gat?att?tgg?ttg?gtc?aca 307

Asp?Val?Asp?His?Ala?Val?Val?Asp?Gly?Ser?Asp?Ile?Trp?Leu?Val?Thr

55 60 65

cac?aac?gcc?gag?ggc?ccg?aac?ttt?tcg?gtg?ggg?tgg?gct?ggc?gtc?gac 355

His?Asn?Ala?Glu?Gly?Pro?Asn?Phe?Ser?Val?Gly?Trp?Ala?Gly?Val?Asp

70 75 80 85

aag?ctc?aat?tct?ttg?gac?gcg?ctg?gcg?cca?ctc?gtc?gcg?cac?aag?gat 403

Lys?Leu?Asn?Ser?Leu?Asp?Ala?Leu?Ala?Pro?Leu?Val?Ala?His?Lys?Asp

90 95 100

gac?gtg?cgc?att?gag?ggt?gtc?gat?acc?tac?cgc?gat?ttc?atc?atc?ctg 451

Asp?Val?Arg?Ile?Glu?Gly?Val?Asp?Thr?Tyr?Arg?Asp?Phe?Ile?Ile?Leu

105 110 115

ggc?tac?agg?tcc?ggc?gcg?atc?ggc?cag?gtc?gcg?atc?atg?aag?ctt?atc 499

Gly?Tyr?Arg?Ser?Gly?Ala?Ile?Gly?Gln?Val?Ala?Ile?Met?Lys?Leu?Ile

120 125 130

gac?gga?acc?ttc?ggc?gat?ttc?caa?cag?ctg?gaa?ttt?gac?gag?gaa?atc 547

Asp?Gly?Thr?Phe?Gly?Asp?Phe?Gln?Gln?Leu?Glu?Phe?Asp?Glu?Glu?Ile

135 140 145

tac?acc?gtc?gca?tcg?ggc?gga?aac?cca?gaa?tgg?gac?gcc?ccc?gtc?att 595

Tyr?Thr?Val?Ala?Ser?Gly?Gly?Asn?Pro?Glu?Trp?Asp?Ala?Pro?Val?Ile

150 155 160 165

cgc?ctt?tct?tac?gga?tca?ttc?acc?acc?ccg?gcg?cag?ctg?ttt?aac?tac 643

Arg?Leu?Ser?Tyr?Gly?Ser?Phe?Thr?Thr?Pro?Ala?Gln?Leu?Phe?Asn?Tyr

170 175 180

tgg?att?gaa?tcc?ggc?gaa?cgc?acg?ctg?ctg?aag?cag?cag?gaa?gtg?ctc 691

Trp?Ile?Glu?Ser?Gly?Glu?Arg?Thr?Leu?Leu?Lys?Gln?Gln?Glu?Val?Leu

185 190 195

ggc?gga?tac?aag?ccg?tca?gac?tat?gtg?gcc?tcc?cga?ttg?tgg?gtc?act 739

Gly?Gly?Tyr?Lys?Pro?Ser?Asp?Tyr?Val?Ala?Ser?Arg?Leu?Trp?Val?Thr

200 205 210

gcg?aaa?gat?ggc?gcg?cag?att?cca?gtg?tcc?ttg?gtg?cac?cgc?acc?gac 787

Ala?Lys?Asp?Gly?Ala?Gln?Ile?Pro?Val?Ser?Leu?Val?His?Arg?Thr?Asp

215 220 225

ctg?gat?gta?tcc?aag?ccc?aac?ccc?acg?ttg?ctc?tac?ggc?tat?ggt?tcc 835

Leu?Asp?Val?Ser?Lys?Pro?Asn?Pro?Thr?Leu?Leu?Tyr?Gly?Tyr?Gly?Ser

230 235 240 245

tac?gaa?tca?tcc?att?gat?cca?ggc?ttc?tct?atc?gcg?cgt?ttg?tca?ctg 883

Tyr?Glu?Ser?Ser?Ile?Asp?Pro?Gly?Phe?Ser?Ile?Ala?Arg?Leu?Ser?Leu

250 255 260

atg?gat?cgt?ggc?atg?att?ttt?gcg?att?gcc?cac?gtt?cgt?ggc?ggt?ggc 931

Met?Asp?Arg?Gly?Met?Ile?Phe?Ala?Ile?Ala?His?Val?Arg?Gly?Gly?Gly

265 270 275

gaa?atg?ggt?cgt?ggc?tgg?tac?gac?aac?ggc?aaa?acc?acc?acg?aag?aaa 979

Glu?Met?Gly?Arg?Gly?Trp?Tyr?Asp?Asn?Gly?Lys?Thr?Thr?Thr?Lys?Lys

280 285 290

aac?acc?ttc?acc?gac?ttc?att?gat?gtt?gcc?gac?gcc?ctc?atc?gag?cag 1027

Asn?Thr?Phe?Thr?Asp?Phe?Ile?Asp?Val?Ala?Asp?Ala?Leu?Ile?Glu?Gln

295 300 305

aag?att?tct?gcc?cct?gaa?atg?ctg?gtt?gca?gaa?ggc?ggc?tca?gct?ggt 1075

Lys?Ile?Ser?Ala?Pro?Glu?Met?Leu?Val?Ala?Glu?Gly?Gly?Ser?Ala?Gly

310 315 320 325

ggc?atg?ctc?atg?ggc?gcc?att?gcc?aac?atg?gcc?ggt?gac?cgc?ttc?aag 1123

Gly?Met?Leu?Met?Gly?Ala?Ile?Ala?Asn?Met?Ala?Gly?Asp?Arg?Phe?Lys

330 335 340

gcg?atc?gaa?gcc?aac?gtg?cca?ttc?gtc?gat?ccg?ctg?acc?tct?atg?ctc 1171

Ala?Ile?Glu?Ala?Asn?Val?Pro?Phe?Val?Asp?Pro?Leu?Thr?Ser?Met?Leu

345 350 355

atg?ccg?gaa?ctg?cca?ctg?acg?gtt?atc?gaa?tgg?gat?gag?tgg?ggc?gat 1219

Met?Pro?Glu?Leu?Pro?Leu?Thr?Val?Ile?Glu?Trp?Asp?Glu?Trp?Gly?Asp

360 365 370

cca?ctc?cac?gat?aag?gac?gtc?tat?gaa?tac?atg?gcg?tcg?tat?gcc?cca 1267

Pro?Leu?His?Asp?Lys?Asp?Val?Tyr?Glu?Tyr?Met?Ala?Ser?Tyr?Ala?Pro

375 380 385

tat?gaa?aac?atc?gag?gca?aag?aac?tac?ccc?aat?atc?ttg?gcc?gta?aca 1315

Tyr?Glu?Asn?Ile?Glu?Ala?Lys?Asn?Tyr?Pro?Asn?Ile?Leu?Ala?Val?Thr

390 395 400 405

tcg?ctc?aac?gac?acc?cga?gtg?ttg?tac?gtc?gaa?cca?gcc?aaa?tgg?gta 1363

Ser?Leu?Asn?Asp?Thr?Arg?Val?Leu?Tyr?Val?Glu?Pro?Ala?Lys?Trp?Val

410 415 420

gcg?cag?ctt?cgg?gcg?act?gca?acc?ggt?gga?gaa?ttc?ctt?ctg?aaa?act 1411

Ala?Gln?Leu?Arg?Ala?Thr?Ala?Thr?Gly?Gly?Glu?Phe?Leu?Leu?Lys?Thr

425 430 435

gaa?atg?gtt?gcc?gga?cac?ggc?ggt?gtg?tca?gga?cgc?tac?gaa?aag?tgg 1459

Glu?Met?Val?Ala?Gly?His?Gly?Gly?Val?Ser?Gly?Arg?Tyr?Glu?Lys?Trp

440 445 450

cgt?gag?act?gca?ttt?gag?tac?ggc?tgg?ttg?atc?aac?caa?gca?acc?ggt 1507

Arg?Glu?Thr?Ala?Phe?Glu?Tyr?Gly?Trp?Leu?Ile?Asn?Gln?Ala?Thr?Gly

455 460 465

gtg?acc?gaa?taaaacttgt?tcgactagcg?aac 1539

Val?Thr?Glu

470

<210>132

<211>472

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>132

Met?Asn?Val?Ile?Pro?Pro?Gly?Trp?Ala?Pro?Leu?Val?Gln?Lys?Lys?Phe

1 5 10 15

Ile?Leu?Phe?Gly?Cys?Ala?Ser?Lys?Ile?Thr?Ser?Glu?Val?Arg?Val?Leu

20 25 30

Pro?Phe?Asp?Gln?Pro?Glu?Gly?Thr?Pro?Glu?Val?Leu?Ile?Pro?Arg?Ala

35 40 45

Glu?Gly?Val?Glu?Tyr?Asp?Val?Asp?His?Ala?Val?Val?Asp?Gly?Ser?Asp

50 55 60

Ile?Trp?Leu?Val?Thr?His?Asn?Ala?Glu?Gly?Pro?Asn?Phe?Ser?Val?Gly

65 70 75 80

Trp?Ala?Gly?Val?Asp?Lys?Leu?Asn?Ser?Leu?Asp?Ala?Leu?Ala?Pro?Leu

85 90 95

Val?Ala?His?Lys?Asp?Asp?Val?Arg?Ile?Glu?Gly?Val?Asp?Thr?Tyr?Arg

100 105 110

Asp?Phe?Ile?Ile?Leu?Gly?Tyr?Arg?Ser?Gly?Ala?Ile?Gly?Gln?Val?Ala

115 120 125

Ile?Met?Lys?Leu?Ile?Asp?Gly?Thr?Phe?Gly?Asp?Phe?Gln?Gln?Leu?Glu

130 135 140

Phe?Asp?Glu?Glu?Ile?Tyr?Thr?Val?Ala?Ser?Gly?Gly?Asn?Pro?Glu?Trp

145 150 155 160

Asp?Ala?Pro?Val?Ile?Arg?Leu?Ser?Tyr?Gly?Ser?Phe?Thr?Thr?Pro?Ala

165 170 175

Gln?Leu?Phe?Asn?Tyr?Trp?Ile?Glu?Ser?Gly?Glu?Arg?Thr?Leu?Leu?Lys

180 185 190

Gln?Gln?Glu?Val?Leu?Gly?Gly?Tyr?Lys?Pro?Ser?Asp?Tyr?Val?Ala?Ser

195 200 205

Arg?Leu?Trp?Val?Thr?Ala?Lys?Asp?Gly?Ala?Gln?Ile?Pro?Val?Ser?Leu

210 215 220

Val?His?Arg?Thr?Asp?Leu?Asp?Val?Ser?Lys?Pro?Asn?Pro?Thr?Leu?Leu

225 230 235 240

Tyr?Gly?Tyr?Gly?Ser?Tyr?Glu?Ser?Ser?Ile?Asp?Pro?Gly?Phe?Set?Ile

245 250 255

Ala?Arg?Leu?Ser?Leu?Met?Asp?Arg?Gly?Met?Ile?Phe?Ala?Ile?Ala?His

260 265 270

Val?Arg?Gly?Gly?Gly?Glu?Met?Gly?Arg?Gly?Trp?Tyr?Asp?Asn?Gly?Lys

275 280 285

Thr?Thr?Thr?Lys?Lys?Asn?Thr?Phe?Thr?Asp?Phe?Ile?Asp?Val?Ala?Asp

290 295 300

Ala?Leu?Ile?Glu?Gln?Lys?Ile?Ser?Ala?Pro?Glu?Met?Leu?Val?Ala?Glu

305 310 315 320

Gly?Gly?Ser?Ala?Gly?Gly?Met?Leu?Met?Gly?Ala?Ile?Ala?Asn?Met?Ala

325 330 335

Gly?Asp?Arg?Phe?Lys?Ala?Ile?Glu?Ala?Asn?Val?Pro?Phe?Val?Asp?Pro

340 345 350

Leu?Thr?Ser?Met?Leu?Met?Pro?Glu?Leu?Pro?Leu?Thr?Val?Ile?Glu?Trp

355 360 365

Asp?Glu?Trp?Gly?Asp?Pro?Leu?His?Asp?Lys?Asp?Val?Tyr?Glu?Tyr?Met

370 375 380

Ala?Ser?Tyr?Ala?Pro?Tyr?Glu?Asn?Ile?Glu?Ala?Lys?Asn?Tyr?Pro?Asn

385 390 395 400

Ile?Leu?Ala?Val?Thr?Ser?Leu?Asn?Asp?Thr?Arg?Val?Leu?Tyr?Val?Glu

405 410 415

Pro?Ala?Lys?Trp?Val?Ala?Gln?Leu?Arg?Ala?Thr?Ala?Thr?Gly?Gly?Glu

420 425 430

Phe?Leu?Leu?Lys?Thr?Glu?Met?Val?Ala?Gly?His?Gly?Gly?Val?Ser?Gly

435 440 445

Arg?Tyr?Glu?Lys?Trp?Arg?Glu?Thr?Ala?Phe?Glu?Tyr?Gly?Trp?Leu?Ile

450 455 460

Asn?Gln?Ala?Thr?Gly?Val?Thr?Glu

465 470

<210>133

<211>1629

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1606)

<223>RXN00982

<400>133

gaaaacaaac?gtccttgaag?ccgtaatgcc?ccgttcgaca?ataaaaaggg?tagtagcagt?60

tcttgccgcc?tcgactgcgc?ttagcccctt?tttggtatca?atg?ccc?act?gca?gca 115

Met?Pro?Thr?Ala?Ala

1 5

gcg?caa?gaa?aac?atc?cgc?tgg?gaa?gaa?tgc?cca?cct?cag?gta?gat?att 163

Ala?Gln?Glu?Asn?Ile?Arg?Trp?Glu?Glu?Cys?Pro?Pro?Gln?Val?Asp?Ile

10 15 20

gcc?tcc?gct?caa?tgt?ggc?agc?atc?gac?gtg?ccc?atg?cac?tat?tct?gat 211

Ala?Ser?Ala?Gln?Cys?Gly?Ser?Ile?Asp?Val?Pro?Met?His?Tyr?Ser?Asp

25 30 35

ccc?tca?ctt?ggc?gat?atc?agc?gtg?ggc?ttt?gtc?aag?gtc?cct?gcc?caa 259

Pro?Ser?Leu?Gly?Asp?Ile?Ser?Val?Gly?Phe?Val?Lys?Val?Pro?Ala?Gln

40 45 50

ggc?gaa?aag?cac?ggc?acc?atc?ttc?ggt?aac?tcc?ggt?ggc?cct?ggt?ggc 307

Gly?Glu?Lys?His?Gly?Thr?Ile?Phe?Gly?Asn?Ser?Gly?Gly?Pro?Gly?Gly

55 60 65

gat?gcc?tat?agc?ttc?ttc?ggc?agc?caa?tcc?atg?aac?tgg?cca?gaa?gcc 355

Asp?Ala?Tyr?Ser?Phe?Phe?Gly?Ser?Gln?Ser?Met?Asn?Trp?Pro?Glu?Ala

70 75 80 85

atg?tac?caa?aac?tac?gac?ctc?gtt?gca?gtg?cag?cct?cgc?gga?atg?gtc 403

Met?Tyr?Gln?Asn?Tyr?Asp?Leu?Val?Ala?Val?Gln?Pro?Arg?Gly?Met?Val

90 95 100

ggc?tcc?aca?ccg?gtt?aac?tgc?gac?aac?atc?gca?cca?gga?tac?gat?ttc 451

Gly?Ser?Thr?Pro?Val?Asn?Cys?Asp?Asn?Ile?Ala?Pro?Gly?Tyr?Asp?Phe

105 110 115

ctc?tcg?ctg?ctc?acc?cgc?gaa?ggc?gct?ttc?gtt?aaa?gaa?tcc?tgc?gag 499

Leu?Ser?Leu?Leu?Thr?Arg?Glu?Gly?Ala?Phe?Val?Lys?Glu?Ser?Cys?Glu

120 125 130

atc?ggc?acc?ccc?ggc?tac?acc?tcc?agc?ctg?acc?acc?gac?aac?acc?gcc 547

Ile?Gly?Thr?Pro?Gly?Tyr?Thr?Ser?Ser?Leu?Thr?Thr?Asp?Asn?Thr?Ala

135 140 145

aac?gac?tgg?gag?cgc?gtc?cgc?caa?gca?ctt?ggc?gat?gac?aag?atc?tcc 595

Asn?Asp?Trp?Glu?Arg?Val?Arg?Gln?Ala?Leu?Gly?Asp?Asp?Lys?Ile?Ser

150 155 160 165

atc?ttc?gga?ctg?tcc?tac?gga?acc?tac?ctc?gga?tcg?gtc?tac?gcc?acc 643

Ile?Phe?Gly?Leu?Ser?Tyr?Gly?Thr?Tyr?Leu?Gly?Ser?Val?Tyr?Ala?Thr

170 175 180

cgc?tac?cca?cag?cac?acc?gac?aag?gtt?gtc?ctc?gat?tcc?gca?atg?gcg 691

Arg?Tyr?Pro?Gln?His?Thr?Asp?Lys?Val?Val?Leu?Asp?Ser?Ala?Met?Ala

185 190 195

ccc?agc?ctg?gca?tgg?aac?ggc?atc?atg?gcc?tcc?caa?gaa?cag?ggc?tac 739

Pro?Ser?Leu?Ala?Trp?Asn?Gly?Ile?Met?Ala?Ser?Gln?Glu?Gln?Gly?Tyr

200 205 210

aaa?aac?tcc?ctc?aac?gac?ttc?ttc?acc?tgg?gtt?gca?gaa?aac?aac?gac 787

Lys?Asn?Ser?Leu?Asn?Asp?Phe?Phe?Thr?Trp?Val?Ala?Glu?Asn?Asn?Asp

215 220 225

acg?tat?ggc?ctc?ggc?act?acc?cca?cta?gcc?gtg?tac?caa?aac?tgg?tca 835

Thr?Tyr?Gly?Leu?Gly?Thr?Thr?Pro?Leu?Ala?Val?Tyr?Gln?Asn?Trp?Ser

230 235 240 245

aac?aag?atc?gtc?gcc?gaa?acc?gga?acc?aac?cca?acc?gtt?gct?cca?cca 883

Asn?Lys?Ile?Val?Ala?Glu?Thr?Gly?Thr?Asn?Pro?Thr?Val?Ala?Pro?Pro

250 255 260

cca?gca?caa?gtt?ggc?gat?gtc?cca?cca?gca?ttc?gca?tgg?gcc?ggc?caa 931

Pro?Ala?Gln?Val?Gly?Asp?Val?Pro?Pro?Ala?Phe?Ala?Trp?Ala?Gly?Gln

265 270 275

gca?ggc?gca?gac?atg?atg?acc?gcc?acc?aac?cca?acc?tcc?gtg?caa?ctc 979

Ala?Gly?Ala?Asp?Met?Met?Thr?Ala?Thr?Asn?Pro?Thr?Ser?Val?Gln?Leu

280 285 290

cag?ggc?ctt?gcc?acc?cag?ctc?cta?aac?cct?gga?tcc?aac?cag?tca?ctg 1027

Gln?Gly?Leu?Ala?Thr?Gln?Leu?Leu?Asn?Pro?Gly?Ser?Asn?Gln?Ser?Leu

295 300 305

agc?cct?ctg?ctc?aac?gtc?acc?cgc?gcc?tac?att?cca?cag?cca?tca?acc 1075

Ser?Pro?Leu?Leu?Asn?Val?Thr?Arg?Ala?Tyr?Ile?Pro?Gln?Pro?Ser?Thr

310 315 320 325

tgg?ccc?atg?ctc?gca?ggc?gcc?atc?tca?ggg?caa?aca?ccc?atc?cct?gac 1123

Trp?Pro?Met?Leu?Ala?Gly?Ala?Ile?Ser?Gly?Gln?Thr?Pro?Ile?Pro?Asp

330 335 340

gta?act?gac?acc?ggc?gac?gac?cca?tac?gtc?atc?gaa?agc?atc?aac?gcc 1171

Val?Thr?Asp?Thr?Gly?Asp?Asp?Pro?Tyr?Val?Ile?Glu?Ser?Ile?Asn?Ala

345 350 355

agc?gtc?aac?atg?cag?cgc?atg?gtc?atg?tgc?aac?gaa?aac?acc?gtc?gca 1219

Ser?Val?Asn?Met?Gln?Arg?Met?Val?Met?Cys?Asn?Glu?Asn?Thr?Val?Ala

360 365 370

cca?gac?cca?gta?gca?atg?gca?cgc?atg?gcc?tgg?aca?agc?atg?gtc?acc 1267

Pro?Asp?Pro?Val?Ala?Met?Ala?Arg?Met?Ala?Trp?Thr?Ser?Met?Val?Thr

375 380 385

ggc?gac?gtc?ttt?gac?att?tac?tcc?gtt?aaa?ttc?agc?tcc?gga?caa?gcc 1315

Gly?Asp?Val?Phe?Asp?Ile?Tyr?Ser?Val?Lys?Phe?Ser?Ser?Gly?Gln?Ala

390 395 400 405

tgc?tcc?ggc?atc?acc?cca?aca?agc?ggc?cgc?cag?cca?acc?gac?gga?tct 1363

Cys?Ser?Gly?Ile?Thr?Pro?Thr?Ser?Gly?Arg?Gln?Pro?Thr?Asp?Gly?Ser

410 415 420

caa?cta?gca?gtc?caa?cca?cta?ctc?ctc?cag?gga?acc?agc?gac?cca?caa 1411

Gln?Leu?Ala?Val?Gln?Pro?Leu?Leu?Leu?Gln?Gly?Thr?Ser?Asp?Pro?Gln

425 430 435

acc?cca?tac?tgg?acc?cac?aac?gag?ctt?gcc?gac?gcc?atg?aac?gcc?cac 1459

Thr?Pro?Tyr?Trp?Thr?His?Asn?Glu?Leu?Ala?Asp?Ala?Met?Asn?Ala?His

440 445 450

gtg?gtc?acc?gtc?aac?gga?cca?gga?cac?ggc?caa?tcc?atc?ggc?ggc?acc 1507

Val?Val?Thr?Val?Asn?Gly?Pro?Gly?His?Gly?Gln?Ser?Ile?Gly?Gly?Thr

455 460 465

aac?caa?gca?atc?aac?gac?att?gtt?gtg?gac?tac?ctc?cgc?acc?gga?cac 1555

Asn?Gln?Ala?Ile?Asn?Asp?Ile?Val?Val?Asp?Tyr?Leu?Arg?Thr?Gly?His

470 475 480 485

acc?gac?gcc?acc?tgg?gtc?gaa?ggc?aac?aca?ccc?acc?cca?att?acg?gct 1603

Thr?Asp?Ala?Thr?Trp?Val?Glu?Gly?Asn?Thr?Pro?Thr?Pro?Ile?Thr?Ala

490 495 500

ggc?taattgcttt?ccacttagta?gat 1629

Gly

<210>134

<211>502

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>134

Met?Pro?Thr?Ala?Ala?Ala?Gln?Glu?Asn?Ile?Arg?Trp?Glu?Glu?Cys?Pro

1 5 10 15

Pro?Gln?Val?Asp?Ile?Ala?Ser?Ala?Gln?Cys?Gly?Ser?Ile?Asp?Val?Pro

20 25 30

Met?His?Tyr?Ser?Asp?Pro?Ser?Leu?Gly?Asp?Ile?Ser?Val?Gly?Phe?Val

35 40 45

Lys?Val?Pro?Ala?Gln?Gly?Glu?Lys?His?Gly?Thr?Ile?Phe?Gly?Asn?Ser

50 55 60

Gly?Gly?Pro?Gly?Gly?Asp?Ala?Tyr?Ser?Phe?Phe?Gly?Ser?Gln?Ser?Met

65 70 75 80

Asn?Trp?Pro?Glu?Ala?Met?Tyr?Gln?Asn?Tyr?Asp?Leu?Val?Ala?Val?Gln

85 90 95

Pro?Arg?Gly?Met?Val?Gly?Ser?Thr?Pro?Val?Asn?Cys?Asp?Asn?Ile?Ala

100 105 110

Pro?Gly?Tyr?Asp?Phe?Leu?Ser?Leu?Leu?Thr?Arg?Glu?Gly?Ala?Phe?Val

115 120 125

Lys?Glu?Ser?Cys?Glu?Ile?Gly?Thr?Pro?Gly?Tyr?Thr?Ser?Ser?Leu?Thr

130 135 140

Thr?Asp?Asn?Thr?Ala?Asn?Asp?Trp?Glu?Arg?Val?Arg?Gln?Ala?Leu?Gly

145 150 155 160

Asp?Asp?Lys?Ile?Ser?Ile?Phe?Gly?Leu?Ser?Tyr?Gly?Thr?Tyr?Leu?Gly

165 170 175

Ser?Val?Tyr?Ala?Thr?Arg?Tyr?Pro?Gln?His?Thr?Asp?Lys?Val?Val?Leu

180 185 190

Asp?Ser?Ala?Met?Ala?Pro?Ser?Leu?Ala?Trp?Asn?Gly?Ile?Met?Ala?Ser

195 200 205

Gln?Glu?Gln?Gly?Tyr?Lys?Asn?Ser?Leu?Asn?Asp?Phe?Phe?Thr?Trp?Val

210 215 220

Ala?Glu?Asn?Asn?Asp?Thr?Tyr?Gly?Leu?Gly?Thr?Thr?Pro?Leu?Ala?Val

225 230 235 240

Tyr?Gln?Asn?Trp?Ser?Asn?Lys?Ile?Val?Ala?Glu?Thr?Gly?Thr?Asn?Pro

245 250 255

Thr?Val?Ala?Pro?Pro?Pro?Ala?Gln?Val?Gly?Asp?Val?Pro?Pro?Ala?Phe

260 265 270

Ala?Trp?Ala?Gly?Gln?Ala?Gly?Ala?Asp?Met?Met?Thr?Ala?Thr?Asn?Pro

275 280 285

Thr?Ser?Val?Gln?Leu?Gln?Gly?Leu?Ala?Thr?Gln?Leu?Leu?Asn?Pro?Gly

290 295 300

Ser?Asn?Gln?Ser?Leu?Ser?Pro?Leu?Leu?Asn?Val?Thr?Arg?Ala?Tyr?Ile

305 310 315 320

Pro?Gln?Pro?Ser?Thr?Trp?Pro?Met?Leu?Ala?Gly?Ala?Ile?Ser?Gly?Gln

325 330 335

Thr?Pro?Ile?Pro?Asp?Val?Thr?Asp?Thr?Gly?Asp?Asp?Pro?Tyr?Val?Ile

340 345 350

Glu?Ser?Ile?Asn?Ala?Ser?Val?Asn?Met?Gln?Arg?Met?Val?Met?Cys?Asn

355 360 365

Glu?Asn?Thr?Val?Ala?Pro?Asp?Pro?Val?Ala?Met?Ala?Arg?Met?Ala?Trp

370 375 380

Thr?Ser?Met?Val?Thr?Gly?Asp?Val?Phe?Asp?Ile?Tyr?Ser?Val?Lys?Phe

385 390 395 400

Ser?Ser?Gly?Gln?Ala?Cys?Ser?Gly?Ile?Thr?Pro?Thr?Ser?Gly?Arg?Gln

405 410 415

Pro?Thr?Asp?Gly?Ser?Gln?Leu?Ala?Val?Gln?Pro?Leu?Leu?Leu?Gln?Gly

420 425 430

Thr?Ser?Asp?Pro?Gln?Thr?Pro?Tyr?Trp?Thr?His?Asn?Glu?Leu?Ala?Asp

435 440 445

Ala?Met?Asn?Ala?His?Val?Val?Thr?Val?Asn?Gly?Pro?Gly?His?Gly?Gln

450 455 460

Ser?Ile?Gly?Gly?Thr?Asn?Gln?Ala?Ile?Asn?Asp?Ile?Val?Val?Asp?Tyr

465 470 475 480

Leu?Arg?Thr?Gly?His?Thr?Asp?Ala?Thr?Trp?Val?Glu?Gly?Asn?Thr?Pro

485 490 495

Thr?Pro?Ile?Thr?Ala?Gly

500

<210>135

<211>1114

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1114)

<223>FRXA00977

<400>135

gaaaacaaac?gtccttgaag?ccgtaatgcc?ccgttcgaca?ataaaaaggg?tagtagcagt?60

tcttgccgcc?tcgactgcgc?ttagcccctt?tttggtatca?atg?ccc?act?gca?gca 115

Met?Pro?Thr?Ala?Ala

1 5

gcg?caa?gaa?aac?atc?cgc?tgg?gaa?gaa?tgc?cca?cct?cag?gta?gat?att 163

Ala?Gln?Glu?Asn?Ile?Arg?Trp?Glu?Glu?Cys?Pro?Pro?Gln?Val?Asp?Ile

10 15 20

gcc?tcc?gct?caa?tgt?ggc?agc?atc?gac?gtg?ccc?atg?cac?tat?tct?gat 211

Ala?Ser?Ala?Gln?Cys?Gly?Ser?Ile?Asp?Val?Pro?Met?His?Tyr?Ser?Asp

25 30 35

ccc?tca?ctt?ggc?gat?atc?agc?gtg?ggc?ttt?gtc?aag?gtc?cct?gcc?caa 259

Pro?Ser?Leu?Gly?Asp?Ile?Ser?Val?Gly?Phe?Val?Lys?Val?Pro?Ala?Gln

40 45 50

ggc?gaa?aag?cac?ggc?acc?atc?ttc?ggt?aac?tcc?ggt?ggc?cct?ggt?ggc 307

Gly?Glu?Lys?His?Gly?Thr?Ile?Phe?Gly?Asn?Ser?Gly?Gly?Pro?Gly?Gly

55 60 65

gat?gcc?tat?agc?ttc?ttc?ggc?agc?caa?tcc?atg?aac?tgg?cca?gaa?gcc 355

Asp?Ala?Tyr?Ser?Phe?Phe?Gly?Ser?Gln?Ser?Met?Asn?Trp?Pro?Glu?Ala

70 75 80 85

atg?tac?caa?aac?tac?gac?ctc?gtt?gca?gtg?cag?cct?cgc?gga?atg?gtc 403

Met?Tyr?Gln?Asn?Tyr?Asp?Leu?Val?Ala?Val?Gln?Pro?Arg?Gly?Met?Val

90 95 100

ggc?tcc?aca?ccg?gtt?aac?tgc?gac?aac?atc?gca?cca?gga?tac?gat?ttc 451

Gly?Ser?Thr?Pro?Val?Asn?Cys?Asp?Asn?Ile?Ala?Pro?Gly?Tyr?Asp?Phe

105 110 115

ctc?tcg?ctg?ctc?acc?cgc?gaa?ggc?gct?ttc?gtt?aaa?gaa?tcc?tgc?gag 499

Leu?Ser?Leu?Leu?Thr?Arg?Glu?Gly?Ala?Phe?Val?Lys?Glu?Ser?Cys?Glu

120 125 130

atc?ggc?acc?ccc?ggc?tac?acc?tcc?agc?ctg?acc?acc?gac?aac?acc?gcc 547

Ile?Gly?Thr?Pro?Gly?Tyr?Thr?Ser?Ser?Leu?Thr?Thr?Asp?Asn?Thr?Ala

135 140 145

aac?gac?tgg?gag?cgc?gtc?cgc?caa?gca?ctt?ggc?gat?gac?aag?atc?tcc 595

Asn?Asp?Trp?Glu?Arg?Val?Arg?Gln?Ala?Leu?Gly?Asp?Asp?Lys?Ile?Ser

150 155 160 165

atc?ttc?gga?ctg?tcc?tac?gga?acc?tac?ctc?gga?tcg?gtc?tac?gcc?acc 643

Ile?Phe?Gly?Leu?Ser?Tyr?Gly?Thr?Tyr?Leu?Gly?Ser?Val?Tyr?Ala?Thr

170 175 180

cgc?tac?cca?cag?cac?acc?gac?aag?gtt?gtc?ctc?gat?tcc?gca?atg?gcg 691

Arg?Tyr?Pro?Gln?His?Thr?Asp?Lys?Val?Val?Leu?Asp?Ser?Ala?Met?Ala

185 190 195

ccc?agc?ctg?gca?tgg?aac?ggc?atc?atg?gcc?tcc?caa?gaa?cag?ggc?tac 739

Pro?Ser?Leu?Ala?Trp?Asn?Gly?Ile?Met?Ala?Ser?Gln?Glu?Gln?Gly?Tyr

200 205 210

aaa?aac?tcc?ctc?aac?gac?ttc?ttc?acc?tgg?gtt?gca?gaa?aac?aac?gac 787

Lys?Asn?Ser?Leu?Asn?Asp?Phe?Phe?Thr?Trp?Val?Ala?Glu?Asn?Asn?Asp

215 220 225

acg?tat?ggc?ctc?ggc?act?acc?cca?cta?gcc?gtg?tac?caa?aac?tgg?tca 835

Thr?Tyr?Gly?Leu?Gly?Thr?Thr?Pro?Leu?Ala?Val?Tyr?Gln?Asn?Trp?Ser

230 235 240 245

aac?aag?atc?gtc?gcc?gaa?acc?gga?acc?aac?cca?acc?gtt?gct?cca?cca 883

Asn?Lys?Ile?Val?Ala?Glu?Thr?Gly?Thr?Asn?Pro?Thr?Val?Ala?Pro?Pro

250 255 260

cca?gca?caa?gtt?ggc?gat?gtc?cca?cca?gca?ttc?gca?tgg?gcc?ggc?caa 931

Pro?Ala?Gln?Val?Gly?Asp?Val?Pro?Pro?Ala?Phe?Ala?Trp?Ala?Gly?Gln

265 270 275

gca?ggc?gca?gac?atg?atg?acc?gcc?acc?aac?cca?acc?tcc?gtg?caa?ctc 979

Ala?Gly?Ala?Asp?Met?Met?Thr?Ala?Thr?Asn?Pro?Thr?Ser?Val?Gln?Leu

280 285 290

cag?ggc?ctt?gcc?acc?cag?ctc?cta?aac?cct?gga?tcc?aac?cag?tca?ctg 1027

Gln?Gly?Leu?Ala?Thr?Gln?Leu?Leu?Asn?Pro?Gly?Ser?Asn?Gln?Ser?Leu

295 300 305

agc?cct?ctg?ctc?aac?gtc?acc?cgc?gcc?tac?att?cca?cag?cca?tca?acc 1075

Ser?Pro?Leu?Leu?Asn?Val?Thr?Arg?Ala?Tyr?Ile?Pro?Gln?Pro?Ser?Thr

310 315 320 325

tgg?ccc?atg?ctc?gca?ggc?gcc?atc?tca?ggg?caa?aca?ccc 1114

Trp?Pro?Met?Leu?Ala?Gly?Ala?Ile?Ser?Gly?Gln?Thr?Pro

330 335

<210>136

<211>338

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>136

Met?Pro?Thr?Ala?Ala?Ala?Gln?Glu?Asn?Ile?Arg?Trp?Glu?Glu?Cys?Pro

1 5 10 15

Pro?Gln?Val?Asp?Ile?Ala?Ser?Ala?Gln?Cys?Gly?Ser?Ile?Asp?Val?Pro

20 25 30

Met?His?Tyr?Ser?Asp?Pro?Ser?Leu?Gly?Asp?Ile?Ser?Val?Gly?Phe?Val

35 40 45

Lys?Val?Pro?Ala?Gln?Gly?Glu?Lys?His?Gly?Thr?Ile?Phe?Gly?Asn?Ser

50 55 60

Gly?Gly?Pro?Gly?Gly?Asp?Ala?Tyr?Ser?Phe?Phe?Gly?Ser?Gln?Ser?Met

65 70 75 80

Asn?Trp?Pro?Glu?Ala?Met?Tyr?Gln?Asn?Tyr?Asp?Leu?Val?Ala?Val?Gln

85 90 95

Pro?Arg?Gly?Met?Val?Gly?Ser?Thr?Pro?Val?Asn?Cys?Asp?Asn?Ile?Ala

100 105 110

Pro?Gly?Tyr?Asp?Phe?Leu?Ser?Leu?Leu?Thr?Arg?Glu?Gly?Ala?Phe?Val

115 120 125

Lys?Glu?Ser?Cys?Glu?Ile?Gly?Thr?Pro?Gly?Tyr?Thr?Ser?Ser?Leu?Thr

130 135 140

Thr?Asp?Asn?Thr?Ala?Asn?Asp?Trp?Glu?Arg?Val?Arg?Gln?Ala?Leu?Gly

145 150 155 160

Asp?Asp?Lys?Ile?Ser?Ile?Phe?Gly?Leu?Ser?Tyr?Gly?Thr?Tyr?Leu?Gly

165 170 175

Ser?Val?Tyr?Ala?Thr?Arg?Tyr?Pro?Gln?His?Thr?Asp?Lys?Val?Val?Leu

180 185 190

Asp?Ser?Ala?Met?Ala?Pro?Ser?Leu?Ala?Trp?Asn?Gly?Ile?Met?Ala?Ser

195 200 205

Gln?Glu?Gln?Gly?Tyr?Lys?Asn?Ser?Leu?Asn?Asp?Phe?Phe?Thr?Trp?Val

210 215 220

Ala?Glu?Asn?Asn?Asp?Thr?Tyr?Gly?Leu?Gly?Thr?Thr?Pro?Leu?Ala?Val

225 230 235 240

Tyr?Gln?Asn?Trp?Ser?Asn?Lys?Ile?Val?Ala?Glu?Thr?Gly?Thr?Asn?Pro

245 250 255

Thr?Val?Ala?Pro?Pro?Pro?Ala?Gln?Val?Gly?Asp?Val?Pro?Pro?Ala?Phe

260 265 270

Ala?Trp?Ala?Gly?Gln?Ala?Gly?Ala?Asp?Met?Met?Thr?Ala?Thr?Asn?Pro

275 280 285

Thr?Ser?Val?Gln?Leu?Gln?Gly?Leu?Ala?Thr?Gln?Leu?Leu?Asn?Pro?Gly

290 295 300

Ser?Asn?Gln?Ser?Leu?Ser?Pro?Leu?Leu?Asn?Val?Thr?Arg?Ala?Tyr?Ile

305 310 315 320

Pro?Gln?Pro?Ser?Thr?Trp?Pro?Met?Leu?Ala?Gly?Ala?Ile?Ser?Gly?Gln

325 330 335

Thr?Pro

<210>137

<211>269

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(246)

<223>FRXA00982

<400>137

tct?caa?cta?gca?gtc?caa?cca?cta?ctc?ctc?cag?gga?acc?agc?gac?cca 48

Ser?Gln?Leu?Ala?Val?Gln?Pro?Leu?Leu?Leu?Gln?Gly?Thr?Ser?Asp?Pro

1 5 10 15

caa?acc?cca?tac?tgg?acc?cac?aac?gag?ctt?gcc?gac?gcc?atg?aac?gcc 96

Gln?Thr?Pro?Tyr?Trp?Thr?His?Asn?Glu?Leu?Ala?Asp?Ala?Met?Asn?Ala

20 25 30

cac?gtg?gtc?acc?gtc?aac?gga?cca?gga?cac?ggc?caa?tcc?atc?ggc?ggc 144

His?Val?Val?Thr?Val?Asn?Gly?Pro?Gly?His?Gly?Gln?Ser?Ile?Gly?Gly

35 40 45

acc?aac?caa?gca?atc?aac?gac?att?gtt?gtg?gac?tac?ctc?cgc?acc?gga 192

Thr?Asn?Gln?Ala?Ile?Asn?Asp?Ile?Val?Val?Asp?Tyr?Leu?Arg?Thr?Gly

50 55 60

cac?acc?gac?gcc?acc?tgg?gtc?gaa?ggc?aac?aca?ccc?acc?cca?att?acg 240

His?Thr?Asp?Ala?Thr?Trp?Val?Glu?Gly?Asn?Thr?Pro?Thr?Pro?Ile?Thr

65 70 75 80

gct?ggc?taattgcttt?ccacttagta?gat 269

Ala?Gly

<210>138

<211>82

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>138

Ser?Gln?Leu?Ala?Val?Gln?Pro?Leu?Leu?Leu?Gln?Gly?Thr?Ser?Asp?Pro

1 5 10 15

Gln?Thr?Pro?Tyr?Trp?Thr?His?Asn?Glu?Leu?Ala?Asp?Ala?Met?Asn?Ala

20 25 30

His?Val?Val?Thr?Val?Asn?Gly?Pro?Gly?His?Gly?Gln?Ser?Ile?Gly?Gly

35 40 45

Thr?Asn?Gln?Ala?Ile?Asn?Asp?Ile?Val?Val?Asp?Tyr?Leu?Arg?Thr?Gly

50 55 60

His?Thr?Asp?Ala?Thr?Trp?Val?Glu?Gly?Asn?Thr?Pro?Thr?Pro?Ile?Thr

65 70 75 80

Ala?Gly

<210>139

<211>1419

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1396)

<223>RXA00152

<400>139

gtcattgata?tccaaggcac?gaccgcgatt?gtatggaaag?aagcctaaat?ttttaacaat?60

caaatagtac?tgg?ccattcc?caactaaaac?tggagtaacg?atg?aca?gga?cta?atc 115

Met?Thr?Gly?Leu?Ile

1 5

ctc?gcc?ata?gtt?ttc?ctg?gtc?ttt?gtc?gcc?gtc?gtg?gtg?atc?aag?tcc 163

Leu?Ala?Ile?Val?Phe?Leu?Val?Phe?Val?Ala?Val?Val?Val?Ile?Lys?Ser

10 15 20

ata?gcc?ctg?att?ccc?cag?ggt?gaa?gcc?gcc?gtc?att?gaa?cgc?ctt?ggt 211

Ile?Ala?Leu?Ile?Pro?Gln?Gly?Glu?Ala?Ala?Val?Ile?Glu?Arg?Leu?Gly

25 30 35

agc?tac?acc?cgc?acc?gtt?tca?ggt?ggc?ctg?acc?ctg?ctg?gtt?cca?ttc 259

Ser?Tyr?Thr?Arg?Thr?Val?Ser?Gly?Gly?Leu?Thr?Leu?Leu?Val?Pro?Phe

40 45 50

gtg?gac?cga?gta?cgc?gca?agg?atc?gac?acc?cgt?gag?cgc?gtg?gtc?tca 307

Val?Asp?Arg?Val?Arg?Ala?Arg?Ile?Asp?Thr?Arg?Glu?Arg?Val?Val?Ser

55 60 65

ttc?cca?ccg?cag?gct?gtt?att?acc?caa?gac?aac?ctg?acc?gtg?gcc?atc 355

Phe?Pro?Pro?Gln?Ala?Val?Ile?Thr?Gln?Asp?Asn?Leu?Thr?Val?Ala?Ile

70 75 80 85

gat?atc?gtg?gtg?acc?ttc?caa?atc?aac?gaa?cca?gag?cgc?gcc?atc?tac 403

Asp?Ile?Val?Val?Thr?Phe?Gln?Ile?Asn?Glu?Pro?Glu?Arg?Ala?Ile?Tyr

90 95 100

ggc?gtg?gac?aac?tac?atc?gtc?ggt?gtg?gag?cag?att?tct?gta?gca?aca 451

Gly?Val?Asp?Asn?Tyr?Ile?Val?Gly?Val?Glu?Gln?Ile?Ser?Val?Ala?Thr

105 110 115

ctt?cga?gac?gtt?gtc?ggt?ggc?atg?acc?ctg?gaa?gaa?acc?ctc?act?tca 499

Leu?Arg?Asp?Val?Val?Gly?Gly?Met?Thr?Leu?Glu?Glu?Thr?Leu?Thr?Ser

120 125 130

cgt?gac?gtg?atc?aac?cgc?cgc?ctc?cgt?ggc?gag?ctc?gat?gca?gca?acc 547

Arg?Asp?Val?Ile?Asn?Arg?Arg?Leu?Arg?Gly?Glu?Leu?Asp?Ala?Ala?Thr

135 140 145

acc?aaa?tgg?ggc?ctg?cgc?atc?agc?cgt?gtg?gaa?cta?aag?gca?att?gat 595

Thr?Lys?Trp?Gly?Leu?Arg?Ile?Ser?Arg?Val?Glu?Leu?Lys?Ala?Ile?Asp

150 155 160 165

ccg?cca?cca?tcc?atc?cag?caa?tcg?atg?gaa?aag?cag?atg?aag?gca?gac 643

Pro?Pro?Pro?Ser?Ile?Gln?Gln?Ser?Met?Glu?Lys?Gln?Met?Lys?Ala?Asp

170 175 180

cgt?gaa?aag?cgc?gcc?acc?att?ttg?acc?gca?gaa?ggt?cag?cgc?gaa?gcc 691

Arg?Glu?Lys?Arg?Ala?Thr?Ile?Leu?Thr?Ala?Glu?Gly?Gln?Arg?Glu?Ala

185 190 195

gac?atc?aaa?act?gcc?gaa?ggt?gaa?aag?caa?gcc?aag?atc?ctc?caa?gct 739

Asp?Ile?Lys?Thr?Ala?Glu?Gly?Glu?Lys?Gln?Ala?Lys?Ile?Leu?Gln?Ala

200 205 210

gag?ggt?gaa?aag?cac?gca?tcc?atc?ctg?aac?gca?gaa?gca?gaa?cgc?caa 787

Glu?Gly?Glu?Lys?His?Ala?Ser?Ile?Leu?Asn?Ala?Glu?Ala?Glu?Arg?Gln

215 220 225

gcg?atg?atc?ctg?cgc?gcc?gaa?ggt?gaa?cgc?gca?gca?cgc?tacctc?cag 835

Ala?Met?Ile?Leu?Arg?Ala?Glu?Gly?Glu?Arg?Ala?Ala?Arg?Tyr?Leu?Gln

230 235 240 245

gcg?cag?ggt?gaa?gcc?cga?gca?atc?caa?aag?gtc?aac?gca?gca?atc?aag 883

Ala?Gln?Gly?Glu?Ala?Arg?Ala?Ile?Gln?Lys?Val?Asn?Ala?Ala?Ile?Lys

250 255 260

tct?gcc?aag?ttg?acc?cca?gag?gtt?ctt?gct?tat?caa?tac?ctc?gaa?aag 931

Ser?Ala?Lys?Leu?Thr?Pro?Glu?Val?Leu?Ala?Tyr?Gln?Tyr?Leu?Glu?Lys

265 270 275

ctt?cct?aag?atc?gca?gag?ggc?aac?gcc?tcc?aag?atg?tgg?gtc?atc?cca 979

Leu?Pro?Lys?Ile?Ala?Glu?Gly?Asn?Ala?Ser?Lys?Met?Trp?Val?Ile?Pro

280 285 290

agc?cag?ttc?tcc?gat?tct?ctg?gaa?ggt?ttt?gcg?aag?cag?ttc?ggc?gca 1027

Ser?Gln?Phe?Ser?Asp?Ser?Leu?Glu?Gly?Phe?Ala?Lys?Gln?Phe?Gly?Ala

295 300 305

aag?gat?gca?gaa?ggt?gtc?ttc?cgc?tac?gaa?cca?aac?acc?gtg?gat?gaa 1075

Lys?Asp?Ala?Glu?Gly?Val?Phe?Arg?Tyr?Glu?Pro?Asn?Thr?Val?Asp?Glu

310 315 320 325

gaa?acc?cgc?gac?atc?gca?aac?gcc?gac?aac?gtg?gaa?gac?tgg?ttc?tcc 1123

Glu?Thr?Arg?Asp?Ile?Ala?Asn?Ala?Asp?Asn?Val?Glu?Asp?Trp?Phe?Ser

330 335 340

acc?gaa?tca?gac?cct?gaa?atc?gca?gca?gca?gtc?gcc?gca?gca?aac?gcc 1171

Thr?Glu?Ser?Asp?Pro?Glu?Ile?Ala?Ala?Ala?Val?Ala?Ala?Ala?Asn?Ala

345 350 355

gtg?gcc?aac?aag?cca?gtc?gat?cca?gaa?ccc?ggt?gag?atc?ctt?tcc?aag 1219

Val?Ala?Asn?Lys?Pro?Val?Asp?Pro?Glu?Pro?Gly?Glu?Ile?Leu?Ser?Lys

360 365 370

aag?acc?gca?cga?cgc?gtt?gaa?cct?gaa?gca?gta?ttg?gag?gct?ttg?caa 1267

Lys?Thr?Ala?Arg?Arg?Val?Glu?Pro?Glu?Ala?Val?Leu?Glu?Ala?Leu?Gln

375 380 385

aac?gga?acc?act?aca?caa?cct?gag?gtt?gag?gca?gca?cct?cct?acc?gca 1315

Asn?Gly?Thr?Thr?Thr?Gln?Pro?Glu?Val?Glu?Ala?Ala?Pro?Pro?Thr?Ala

390 395 400 405

aac?ttc?gcc?caa?gaa?ttc?cct?gca?cca?cag?gca?aac?cct?gaa?gat?tac 1363

Asn?Phe?Ala?Gln?Glu?Phe?Pro?Ala?Pro?Gln?Ala?Asn?Pro?Glu?Asp?Tyr

410 415 420

tcc?gac?caa?cac?cga?gag?aat?cct?tac?gga?aac?taatcaggca?taagaaaagg?1416

Ser?Asp?Gln?His?Arg?Glu?Asn?Pro?Tyr?Gly?Asn

425 430

cgg

1419

<210>140

<211>432

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>140

Met?Thr?Gly?Leu?Ile?Leu?Ala?Ile?Val?Phe?Leu?Val?Phe?Val?Ala?Val

1 5 10 15

Val?Val?Ile?Lys?Ser?Ile?Ala?Leu?Ile?Pro?Gln?Gly?Glu?Ala?Ala?Val

20 25 30

Ile?Glu?Arg?Leu?Gly?Ser?Tyr?Thr?Arg?Thr?Val?Ser?Gly?Gly?Leu?Thr

35 40 45

Leu?Leu?Val?Pro?Phe?Val?Asp?Arg?Val?Arg?Ala?Arg?Ile?Asp?Thr?Arg

50 55 60

Glu?Arg?Val?Val?Ser?Phe?Pro?Pro?Gln?Ala?Val?Ile?Thr?Gln?Asp?Asn

65 70 75 80

Leu?Thr?Val?Ala?Ile?Asp?Ile?Val?Val?Thr?Phe?Gln?Ile?Asn?Glu?Pro

85 90 95

Glu?Arg?Ala?Ile?Tyr?Gly?Val?Asp?Asn?Tyr?Ile?Val?Gly?Val?Glu?Gln

100 105 110

Ile?Ser?Val?Ala?Thr?Leu?Arg?Asp?Val?Val?Gly?Gly?Met?Thr?Leu?Glu

115 120 125

Glu?Thr?Leu?Thr?Ser?Arg?Asp?Val?Ile?Asn?Arg?Arg?Leu?Arg?Gly?Glu

130 135 140

Leu?Asp?Ala?Ala?Thr?Thr?Lys?Trp?Gly?Leu?Arg?Ile?Ser?Arg?Val?Glu

145 150 155 160

Leu?Lys?Ala?Ile?Asp?Pro?Pro?Pro?Ser?Ile?Gln?Gln?Ser?Met?Glu?Lys

165 170 175

Gln?Met?Lys?Ala?Asp?Arg?Glu?Lys?Arg?Ala?Thr?Ile?Leu?Thr?Ala?Glu

180 185 190

Gly?Gln?Arg?Glu?Ala?Asp?Ile?Lys?Thr?Ala?Glu?Gly?Glu?Lys?Gln?Ala

195 200 205

Lys?Ile?Leu?Gln?Ala?Glu?Gly?Glu?Lys?His?Ala?Ser?Ile?Leu?Asn?Ala

210 215 220

Glu?Ala?Glu?Arg?Gln?Ala?Met?Ile?Leu?Arg?Ala?Glu?Gly?Glu?Arg?Ala

225 230 235 240

Ala?Arg?Tyr?Leu?Gln?Ala?Gln?Gly?Glu?Ala?Arg?Ala?Ile?Gln?Lys?Val

245 250 255

Asn?Ala?Ala?Ile?Lys?Ser?Ala?Lys?Leu?Thr?Pro?Glu?Val?Leu?Ala?Tyr

260 265 270

Gln?Tyr?Leu?Glu?Lys?Leu?Pro?Lys?Ile?Ala?Glu?Gly?Asn?Ala?Ser?Lys

275 280 285

Met?Trp?Val?Ile?Pro?Ser?Gln?Phe?Ser?Asp?Ser?Leu?Glu?Gly?Phe?Ala

290 295 300

Lys?Gln?Phe?Gly?Ala?Lys?Asp?Ala?Glu?Gly?Val?Phe?Arg?Tyr?Glu?Pro

305 310 315 320

Asn?Thr?Val?Asp?Glu?Glu?Thr?Arg?Asp?Ile?Ala?Asn?Ala?Asp?Asn?Val

325 330 335

Glu?Asp?Trp?Phe?Ser?Thr?Glu?Ser?Asp?Pro?Glu?Ile?Ala?Ala?Ala?Val

340 345 350

Ala?Ala?Ala?Asn?Ala?Val?Ala?Asn?Lys?Pro?Val?Asp?Pro?Glu?Pro?Gly

355 360 365

Glu?Ile?Leu?Ser?Lys?Lys?Thr?Ala?Arg?Arg?Val?Glu?Pro?Glu?Ala?Val

370 375 380

Leu?Glu?Ala?Leu?Gln?Asn?Gly?Thr?Thr?Thr?Gln?Pro?Glu?Val?Glu?Ala

385 390 395 400

Ala?Pro?Pro?Thr?Ala?Asn?Phe?Ala?Gln?Glu?Phe?Pro?Ala?Pro?Gln?Ala

405 410 415

Asn?Pro?Glu?Asp?Tyr?Ser?Asp?Gln?His?Arg?Glu?Asn?Pro?Tyr?Gly?Asn

420 425 430

<210>141

<211>1098

<212>DNA

＜213〉Corynebacterium glutamicum (C0rynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1075)

<223>RXA02558

<400>141

ccctcccgaa?attagaaatc?cccttttaat?gtgatatcac?tttctgttaa?actgatatca?60

cattcttttt?cagcacccca?gacttaaaag?gagcaccacc?atg?agc?acc?ata?gaa 115

Met?Ser?Thr?Ile?Glu

1 5

gag?cgc?act?cct?gga?gct?gtc?gcc?aca?gaa?cca?gtg?gga?cac?gaa?ggc 163

Glu?Arg?Thr?Pro?Gly?Ala?Val?Ala?Thr?Glu?Pro?Val?Gly?His?Glu?Gly

10 15 20

gca?cgc?gtc?agc?att?aat?gag?aag?aac?gtg?tgg?tct?ttg?ggc?gca?ggt 211

Ala?Arg?Val?Ser?Ile?Asn?Glu?Lys?Asn?Val?Trp?Ser?Leu?Gly?Ala?Gly

25 30 35

cca?gca?gct?ttc?gca?ctg?ctc?gca?atg?att?gtg?ctc?atg?att?gcc?agt 259

Pro?Ala?Ala?Phe?Ala?Leu?Leu?Ala?Met?Ile?Val?Leu?Met?Ile?Ala?Ser

40 45 50

gga?gtt?ttc?ttc?gct?caa?tcc?atc?aac?act?tta?gaa?aac?gat?ggc?ggt 307

Gly?Val?Phe?Phe?Ala?Gln?Ser?Ile?Asn?Thr?Leu?Glu?Asn?Asp?Gly?Gly

55 60 65

gga?aca?ctt?gcg?gtt?acg?gga?ctg?att?gcc?agc?atc?gtc?gtt?ttc?act 355

Gly?Thr?Leu?Ala?Val?Thr?Gly?Leu?Ile?Ala?Ser?Ile?Val?Val?Phe?Thr

70 75 80 85

gtt?gca?ttg?gtg?gtc?acc?ata?act?tcg?gtg?aag?gtg?gtc?agc?cct?gga 403

Val?Ala?Leu?Val?Val?Thr?Ile?Thr?Ser?Val?Lys?Val?Val?Ser?Pro?Gly

90 95 100

cat?act?ctg?act?gtg?cag?ttc?ttt?gga?cga?tac?atc?gga?acc?ctg?cgt 451

His?Thr?Leu?Thr?Val?Gln?Phe?Phe?Gly?Arg?Tyr?Ile?Gly?Thr?Leu?Arg

105 110 115

cga?act?ggg?ttg?tct?ttc?gtt?ccc?cca?ctg?tct?gtg?acg?aag?aaa?gtg 499

Arg?Thr?Gly?Leu?Ser?Phe?Val?Pro?Pro?Leu?Ser?Val?Thr?Lys?Lys?Val

120 125 130

tcc?gtg?agg?gtc?cga?aac?ttt?gaa?acc?aac?gaa?gcc?aaa?gtt?aat?gac 547

Ser?Val?Arg?Val?Arg?Asn?Phe?Glu?Thr?Asn?Glu?Ala?Lys?Val?Asn?Asp

135 140 145

tac?aac?ggc?aac?ccc?atc?aac?att?gca?gcg?atc?atc?gtg?tgg?cag?gta 595

Tyr?Asn?Gly?Asn?Pro?Ile?Asn?Ile?Ala?Ala?Ile?Ile?Val?Trp?Gln?Val

150 155 160 165

gcc?gat?act?gca?cag?gct?agc?ttc?tct?gtg?gag?gat?ttc?gaa?gag?ttc 643

Ala?Asp?Thr?Ala?Gln?Ala?Ser?Phe?Ser?Val?Glu?Asp?Phe?Glu?Glu?Phe

170 175 180

ctg?cac?cag?cag?gcc?gag?tcc?gca?ctg?cgt?cac?gtg?gca?acc?cag?cac 691

Leu?His?Gln?Gln?Ala?Glu?Ser?Ala?Leu?Arg?His?Val?Ala?Thr?Gln?His

185 190 195

ccc?tat?gat?tcc?cca?gtt?gat?ggt?cgt?gtt?tcc?ttg?cgt?ggc?gct?acc 739

Pro?Tyr?Asp?Ser?Pro?Val?Asp?Gly?Arg?Val?Ser?Leu?Arg?Gly?Ala?Thr

200 205 210

gat?gag?gtc?agt?gaa?gaa?ctc?gca?gat?gag?gtg?gca?caa?cga?gca?gct 787

Asp?Glu?Val?Ser?Glu?Glu?Leu?Ala?Asp?Glu?Val?Ala?Gln?Arg?Ala?Ala

215 220 225

gtt?gca?ggt?ctt?gaa?atc?gtc?gaa?gcc?cgc?atc?tct?tcc?ttg?agc?tac 835

Val?Ala?Gly?Leu?Glu?Ile?Val?Glu?Ala?Arg?Ile?Ser?Ser?Leu?Ser?Tyr

230 235 240 245

gca?ccg?gaa?att?gcc?cag?gcg?atg?ctg?cag?cgc?cag?cag?gct?tcc?gcg 883

Ala?Pro?Glu?Ile?Ala?Gln?Ala?Met?Leu?Gln?Arg?Gln?Gln?Ala?Ser?Ala

250 255 260

att?gtt?gat?gcc?cgc?gaa?aag?atc?gtc?gag?ggc?gct?gtc?acc?atg?gtg 931

Ile?Val?Asp?Ala?Arg?Glu?Lys?Ile?Val?Glu?Gly?Ala?Val?Thr?Met?Val

265 270 275

gaa?acc?gca?ctt?gac?cag?ctt?gag?caa?cgt?gaa?att?gtg?gat?ttg?gat 979

Glu?Thr?Ala?Leu?Asp?Gln?Leu?Glu?Gln?Arg?Glu?Ile?Val?Asp?Leu?Asp

280 285 290

cca?gag?cga?cgc?gcc?gcg?atg?gtt?tcc?aac?ctg?ttg?gtt?gtg?ttg?tgt 1027

Pro?Glu?Arg?Arg?Ala?Ala?Met?Val?Ser?Asn?Leu?Leu?Val?Val?Leu?Cys

295 300 305

tcc?gac?acc?aat?gct?cag?cca?atc?gtc?aac?gcc?ggt?agc?ctc?tac?caa 1075

Ser?Asp?Thr?Asn?Ala?Gln?Pro?Ile?Val?Asn?Ala?Gly?Ser?Leu?Tyr?Gln

310 315 320 325

taagacaatg?gcccgcaaac?agg 1098

<210>142

<211>325

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>142

Met?Ser?Thr?Ile?Glu?Glu?Arg?Thr?Pro?Gly?Ala?Val?Ala?Thr?Glu?Pro

1 5 10 15

Val?Gly?His?Glu?Gly?Ala?Arg?Val?Ser?Ile?Asn?Glu?Lys?Asn?Val?Trp

20 25 30

Ser?Leu?Gly?Ala?Gly?Pro?Ala?Ala?Phe?Ala?Leu?Leu?Ala?Met?Ile?Val

35 40 45

Leu?Met?Ile?Ala?Ser?Gly?Val?Phe?Phe?Ala?Gln?Ser?Ile?Asn?Thr?Leu

50 55 60

Glu?Asn?Asp?Gly?Gly?Gly?Thr?Leu?Ala?Val?Thr?Gly?Leu?Ile?Ala?Ser

65 70 75 80

Ile?Val?Val?Phe?Thr?Val?Ala?Leu?Val?Val?Thr?Ile?Thr?Ser?Val?Lys

85 90 95

Val?Val?Ser?Pro?Gly?His?Thr?Leu?Thr?Val?Gln?Phe?Phe?Gly?Arg?Tyr

100 105 110

Ile?Gly?Thr?Leu?Arg?Arg?Thr?Gly?Leu?Ser?Phe?Val?Pro?Pro?Leu?Ser

115 120 125

Val?Thr?Lys?Lys?Val?Ser?Val?Arg?Val?Arg?Asn?Phe?Glu?Thr?Asn?Glu

130 135 140

Ala?Lys?Val?Asn?Asp?Tyr?Asn?Gly?Asn?Pro?Ile?Asn?Ile?Ala?Ala?Ile

145 150 155 160

Ile?Val?Trp?Gln?Val?Ala?Asp?Thr?Ala?Gln?Ala?Ser?Phe?Ser?Val?Glu

165 170 175

Asp?Phe?Glu?Glu?Phe?Leu?His?Gln?Gln?Ala?Glu?Ser?Ala?Leu?Arg?His

180 185 190

Val?Ala?Thr?Gln?His?Pro?Tyr?Asp?Ser?Pro?Val?Asp?Gly?Arg?Val?Ser

195 200 205

Leu?Arg?Gly?Ala?Thr?Asp?Glu?Val?Ser?Glu?Glu?Leu?Ala?Asp?Glu?Val

210 215 220

Ala?Gln?Arg?Ala?Ala?Val?Ala?Gly?Leu?Glu?Ile?Val?Glu?Ala?Arg?Ile

225 230 235 240

Ser?Ser?Leu?Ser?Tyr?Ala?Pro?Glu?Ile?Ala?Gln?Ala?Met?Leu?Gln?Arg

245 250 255

Gln?Gln?Ala?Ser?Ala?Ile?Val?Asp?Ala?Arg?Glu?Lys?Ile?Val?Glu?Gly

260 265 270

Ala?Val?Thr?Met?Val?Glu?Thr?Ala?Leu?Asp?Gln?Leu?Glu?Gln?Arg?Glu

275 280 285

Ile?Val?Asp?Leu?Asp?Pro?Glu?Arg?Arg?Ala?Ala?Met?Val?Set?Asn?Leu

290 295 300

Leu?Val?Val?Leu?Cys?Ser?Asp?Thr?Asn?Ala?Gln?Pro?Ile?Val?Asn?Ala

305 310 315 320

Gly?Ser?Leu?Tyr?Gln

325

<210>143

<211>798

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(775)

<223>RXA00500

<400>143

caccagccag?catgaacaca?atggacttcg?tgccagctca?ggcgcagtac?tgaagcacct?60

tttcgatctg?gcccacggcc?gagaggtacg?ctgattcctc?gtg?tta?gta?cta?gcc 115

Val?Leu?Val?Leu?Ala

1 5

cta?gac?acc?tca?acc?cct?gac?ctg?atc?gtc?ggc?gtc?gtc?gac?tcc?gac 163

Leu?Asp?Thr?Ser?Thr?Pro?Asp?Leu?Ile?Val?Gly?Val?Val?Asp?Ser?Asp

10 15 20

acc?gga?aac?acc?cgc?gcc?gaa?acc?atc?atc?gag?gac?acc?cgc?gca?cac 211

Thr?Gly?Asn?Thr?Arg?Ala?Glu?Thr?Ile?Ile?Glu?Asp?Thr?Arg?Ala?His

25 30 35

aac?gag?cag?ctc?acg?ccc?acc?gtc?cag?aag?acg?ctt?ctc?gac?gcc?aac 259

Asn?Glu?Gln?Leu?Thr?Pro?Thr?Val?Gln?Lys?Thr?Leu?Leu?Asp?Ala?Asn

40 45 50

ttg?agc?ttt?tca?gat?atc?gac?gcg?atc?gtc?gtg?ggt?tgc?ggc?ccg?gga 307

Leu?Ser?Phe?Ser?Asp?Ile?Asp?Ala?Ile?Val?Val?Gly?Cys?Gly?Pro?Gly

55 60 65

ccg?ttc?act?gga?ctt?cga?gta?ggc?atg?gtg?tcc?ggc?gca?gcg?ttc?ggt 355

Pro?Phe?Thr?Gly?Leu?Arg?Val?Gly?Met?Val?Ser?Gly?Ala?Ala?Phe?Gly

70 75 80 85

gat?gcc?ctg?gga?atc?cct?gtc?tat?gga?gtc?tgc?tca?ctc?gac?gcg?atc 403

Asp?Ala?Leu?Gly?Ile?Pro?Val?Tyr?Gly?Val?Cys?Ser?Leu?Asp?Ala?Ile

90 95 100

gct?cac?aat?att?ggt?gca?cgc?aac?atc?ccg?cac?gca?tta?gtt?gcc?act 451

Ala?His?Asn?Ile?Gly?Ala?Arg?Asn?Ile?Pro?His?Ala?Leu?Val?Ala?Thr

105 110 115

gat?gcg?cgc?cgc?cgt?gaa?atc?tac?tgg?gca?acc?tac?cgc?tcc?ggc?gaa 499

Asp?Ala?Arg?Arg?Arg?Glu?Ile?Tyr?Trp?Ala?Thr?Tyr?Arg?Ser?Gly?Glu

120 125 130

cgt?gat?cag?gga?cca?gat?gtc?atc?gca?cca?gca?aac?atc?cag?atc?agc 547

Arg?Asp?Gln?Gly?Pro?Asp?Val?Ile?Ala?Pro?Ala?Asn?Ile?Gln?Ile?Ser

135 140 145

ggc?gct?gta?gac?acc?att?tcg?att?cct?gag?cac?ctg?gtg?gaa?aaa?ctc 595

Gly?Ala?Val?Asp?Thr?Ile?Ser?Ile?Pro?Glu?His?Leu?Val?Glu?Lys?Leu

150 155 160 165

cca?gaa?gaa?ctc?cag?aat?gtc?acc?atg?cat?agc?ggc?aaa?cct?gcc?ccc 643

Pro?Glu?Glu?Leu?Gln?Asn?Val?Thr?Met?His?Ser?Gly?Lys?Pro?Ala?Pro

170 175 180

gca?agc?ttg?gtg?gca?gtg?gct?gat?ttc?agt?gtg?gaa?cca?caa?cca?ttg 691

Ala?Ser?Leu?Val?Ala?Val?Ala?Asp?Phe?Ser?Val?Glu?Pro?Gln?Pro?Leu

185 190 195

gtt?cct?ctt?tac?ctg?cgc?cgc?cca?gat?gcc?aaa?gaa?cca?aaa?cca?aaa 739

Val?Pro?Leu?Tyr?Leu?Arg?Arg?Pro?Asp?Ala?Lys?Glu?Pro?Lys?Pro?Lys

200 205 210

cct?aaa?tct?gca?gcc?atc?ccc?gag?gtg?gat?ctt?tca?tgagtgaaca 785

Pro?Lys?Ser?Ala?Ala?Ile?Pro?Glu?Val?Asp?Leu?Ser

215 220 225

attcgagcta?cgg 798

<210>144

<211>225

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>144

Val?Leu?Val?Leu?Ala?Leu?Asp?Thr?Ser?Thr?Pro?Asp?Leu?Ile?Val?Gly

1 5 10 15

Val?Val?Asp?Ser?Asp?Thr?Gly?Asn?Thr?Arg?Ala?Glu?Thr?Ile?Ile?Glu

20 25 30

Asp?Thr?Arg?Ala?His?Asn?Glu?Gln?Leu?Thr?Pro?Thr?Val?Gln?Lys?Thr

35 40 45

Leu?Leu?Asp?Ala?Asn?Leu?Ser?Phe?Ser?Asp?Ile?Asp?Ala?Ile?Val?Val

50 55 60

Gly?Cys?Gly?Pro?Gly?Pro?Phe?Thr?Gly?Leu?Arg?Val?Gly?Met?Val?Ser

65 70 75 80

Gly?Ala?Ala?Phe?Gly?Asp?Ala?Leu?Gly?Ile?Pro?Val?Tyr?Gly?Val?Cys

85 90 95

Ser?Leu?Asp?Ala?Ile?Ala?His?Asn?Ile?Gly?Ala?Arg?Asn?Ile?Pro?His

100 105 110

Ala?Leu?Val?Ala?Thr?Asp?Ala?Arg?Arg?Arg?Glu?Ile?Tyr?Trp?Ala?Thr

115 120 125

Tyr?Arg?Ser?Gly?Glu?Arg?Asp?Gln?Gly?Pro?Asp?Val?Ile?Ala?Pro?Ala

130 135 140

Asn?Ile?Gln?Ile?Ser?Gly?Ala?Val?Asp?Thr?Ile?Ser?Ile?Pro?Glu?His

145 150 155 160

Leu?Val?Glu?Lys?Leu?Pro?Glu?Glu?Leu?Gln?Asn?Val?Thr?Met?His?Ser

165 170 175

Gly?Lys?Pro?Ala?Pro?Ala?Ser?Leu?Val?Ala?Val?Ala?Asp?Phe?Ser?Val

180 185 190

Glu?Pro?Gln?Pro?Leu?Val?Pro?Leu?Tyr?Leu?Arg?Arg?Pro?Asp?Ala?Lys

195 200 205

Glu?Pro?Lys?Pro?Lys?Pro?Lys?Ser?Ala?Ala?Ile?Pro?Glu?Val?Asp?Leu

210 215 220

Ser

225

<210>145

<211>630

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(607)

<223>RXA00501

<400>145

tggaaccaca?accattggtt?cctctttacc?tgcgccgccc?agatgccaaa?gaaccaaaac?60

caaaacctaa?atctgcagcc?atccccgagg?tggatctttc?atg?agt?gaa?caa?ttc 115

Met?Ser?Glu?Gln?Phe

1 5

gag?cta?cgg?gaa?ctc?cgc?agg?gaa?gac?gcg?ggg?cgc?tgc?gcc?gac?ctg 163

Glu?Leu?Arg?Glu?Leu?Arg?Arg?Glu?Asp?Ala?Gly?Arg?Cys?Ala?Asp?Leu

10 15 20

gag?caa?atc?ctg?ttc?cca?ggt?gat?aac?ccc?tgg?cca?cgt?gat?gtc?ttt 211

Glu?Gln?Ile?Leu?Phe?Pro?Gly?Asp?Asn?Pro?Trp?Pro?Arg?Asp?Val?Phe

25 30 35

gcc?gtg?gag?ttt?tcc?cac?ccc?acc?aat?ttc?tac?atc?ggc?gct?ttc?gac 259

Ala?Val?Glu?Phe?Ser?His?Pro?Thr?Asn?Phe?Tyr?Ile?Gly?Ala?Phe?Asp

40 45 50

gaa?gga?tac?ttg?gtg?gcg?tac?gca?ggt?ctt?gcc?atg?atg?gga?cct?gcg 307

Glu?Gly?Tyr?Leu?Val?Ala?Tyr?Ala?Gly?Leu?Ala?Met?Met?Gly?Pro?Ala

55 60 65

gat?gat?cca?gag?ttt?gaa?atc?cac?acc?att?ggt?gtc?gat?ccg?gaa?ttc 355

Asp?Asp?Pro?Glu?Phe?Glu?Ile?His?Thr?Ile?Gly?Val?Asp?Pro?Glu?Phe

70 75 80 85

caa?aga?aaa?ggc?ttg?gga?cgc?gta?ctc?atg?gat?caa?atg?atg?cat?gca 403

Gln?Arg?Lys?Gly?Leu?Gly?Arg?Val?Leu?Met?Asp?Gln?Met?Met?His?Ala

90 95 100

gcg?gac?agc?cac?gac?ggt?cca?gtt?ttc?ttg?gaa?gtc?cgc?acc?gac?aac 451

Ala?Asp?Ser?His?Asp?Gly?Pro?Val?Phe?Leu?Glu?Val?Arg?Thr?Asp?Asn

105 110 115

gta?ccc?gcg?att?tcc?atg?tac?gag?gct?ttc?ggc?ttt?aaa?acc?ttg?gcc 499

Val?Pro?Ala?Ile?Ser?Met?Tyr?Glu?Ala?Phe?Gly?Phe?Lys?Thr?Leu?Ala

120 125 130

gtg?cgc?aaa?aac?tac?tac?cgg?cca?tcc?gga?gct?gac?gcc?tac?acc?atg 547

Val?Arg?Lys?Asn?Tyr?Tyr?Arg?Pro?Ser?Gly?Ala?Asp?Ala?Tyr?Thr?Met

135 140 145

caa?cgc?cca?cgc?ttg?agc?gat?cgc?aaa?gat?caa?cag?aca?gac?aca?gag 595

Gln?Arg?Pro?Arg?Leu?Ser?Asp?Arg?Lys?Asp?Gln?Gln?Thr?Asp?Thr?Glu

150 155 160 165

ggg?aca?ccc?agc?taaaccatga?tcgttttggg?aat 630

Gly?Thr?Pro?Ser

<210>146

<211>169

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>146

Met?Ser?Glu?Gln?Phe?Glu?Leu?Arg?Glu?Leu?Arg?Arg?Glu?Asp?Ala?Gly

1 5 10 15

Arg?Cys?Ala?Asp?Leu?Glu?Gln?Ile?Leu?Phe?Pro?Gly?Asp?Asn?Pro?Trp

20 25 30

Pro?Arg?Asp?Val?Phe?Ala?Val?Glu?Phe?Ser?His?Pro?Thr?Asn?Phe?Tyr

35 40 45

Ile?Gly?Ala?Phe?Asp?Glu?Gly?Tyr?Leu?Val?Ala?Tyr?Ala?Gly?Leu?Ala

50 55 60

Met?Met?Gly?Pro?Ala?Asp?Asp?Pro?Glu?Phe?Glu?Ile?His?Thr?Ile?Gly

65 70 75 80

Val?Asp?Pro?Glu?Phe?Gln?Arg?Lys?Gly?Leu?Gly?Arg?Val?Leu?Met?Asp

85 90 95

Gln?Met?Met?His?Ala?Ala?Asp?Ser?His?Asp?Gly?Pro?Val?Phe?Leu?Glu

100 105 110

Val?Arg?Thr?Asp?Asn?Val?Pro?Ala?Ile?Ser?Met?Tyr?Glu?Ala?Phe?Gly

115 120 125

Phe?Lys?Thr?Leu?Ala?Val?Arg?Lys?Asn?Tyr?Tyr?Arg?Pro?Ser?Gly?Ala

130 135 140

Asp?Ala?Tyr?Thr?Met?Gln?Arg?Pro?Arg?Leu?Ser?Asp?Arg?Lys?Asp?Gln

145 150 155 160

Gln?Thr?Asp?Thr?Glu?Gly?Thr?Pro?Ser

165

<210>147

<211>1155

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1132)

<223>RXA00502

<400>147

ctaccggcca?tccggagctg?acgcctacac?catgcaacgc?ccacgcttga?gcgatcgcaa?60

agatcaacag?acagacacag?aggggacacc?cagctaaacc?atg?atc?gtt?ttg?gga 115

Met?Ile?Val?Leu?Gly

1 5

att?gaa?agc?tcc?tgc?gat?gaa?aca?ggc?gta?ggc?gta?gtc?aaa?ctt?gac 163

Ile?Glu?Ser?Ser?Cys?Asp?Glu?Thr?Gly?Val?Gly?Val?Val?Lys?Leu?Asp

10 15 20

ggc?gaa?gga?aac?cta?gag?atc?ctc?gcc?gac?tca?gtg?gcc?tcc?tcc?atg 211

Gly?Glu?Gly?Asn?Leu?Glu?Ile?Leu?Ala?Asp?Ser?Val?Ala?Ser?Ser?Met

25 30 35

caa?gaa?cat?gcc?cgc?ttt?ggt?ggc?gtc?gtg?cca?gaa?atc?gcc?tcc?cgg 259

Gln?Glu?His?Ala?Arg?Phe?Gly?Gly?Val?Val?Pro?Glu?Ile?Ala?Ser?Arg

40 45 50

gcg?cac?ctg?gaa?tct?atg?gtc?ccc?gtg?atg?cgt?gaa?gcg?ttg?agg?cag 307

Ala?His?Leu?Glu?Ser?Met?Val?Pro?Val?Met?Arg?Glu?Ala?Leu?Arg?Gln

55 60 65

gcg?ggc?gtc?gac?agg?cca?gat?gct?gtg?gct?gca?acc?gtg?ggc?cct?ggt 355

Ala?Gly?Val?Asp?Arg?Pro?Asp?Ala?Val?Ala?Ala?Thr?Val?Gly?Pro?Gly

70 75 80 85

ttg?gcg?ggc?gcg?ctg?ctc?gtt?gga?gcc?agc?gct?gcg?aag?gcg?tat?gcc 403

Leu?Ala?Gly?Ala?Leu?Leu?Val?Gly?Ala?Ser?Ala?Ala?Lys?Ala?Tyr?Ala

90 95 100

gct?gcg?tgg?gga?gtt?ccg?ttt?tac?gcg?gtc?aac?cac?ctg?ggc?gga?cac 451

Ala?Ala?Trp?Gly?Val?Pro?Phe?Tyr?Ala?Val?Asn?His?Leu?Gly?Gly?His

105 110 115

gtc?gcc?gtg?gcc?aat?ctg?gaa?ggt?gaa?act?ctt?cca?cac?gcg?gtg?gct 499

Val?Ala?Val?Ala?Asn?Leu?Glu?Gly?Glu?Thr?Leu?Pro?His?Ala?Val?Ala

120 125 130

ttg?ctg?gtt?tcc?ggc?gga?cac?act?caa?ttg?ttg?gaa?gtc?gac?gcg?gtg 547

Leu?Leu?Val?Ser?Gly?Gly?His?Thr?Gln?Leu?Leu?Glu?Val?Asp?Ala?Val

135 140 145

gga?tta?ccc?atg?aag?gaa?ttg?gga?tcc?acc?ctc?gac?gat?gcc?gct?ggc 595

Gly?Leu?Pro?Met?Lys?Glu?Leu?Gly?Ser?Thr?Leu?Asp?Asp?Ala?Ala?Gly

150 155 160 165

gaa?gcc?tat?gac?aaa?gtc?tca?agg?ctg?ttg?gga?ttg?ggc?tac?cca?ggc 643

Glu?Ala?Tyr?Asp?Lys?Val?Ser?Arg?Leu?Leu?Gly?Leu?Gly?Tyr?Pro?Gly

170 175 180

ggc?ccc?atc?att?gat?aaa?ttg?gcg?cgc?cgg?ggt?aat?cca?gag?gcc?att 691

Gly?Pro?Ile?Ile?Asp?Lys?Leu?Ala?Arg?Arg?Gly?Asn?Pro?Glu?Ala?Ile

185 190 195

gct?ttc?ccc?cgc?gga?ttg?atg?aaa?aag?tcg?gat?tct?cgg?cat?gat?ttc 739

Ala?Phe?Pro?Arg?Gly?Leu?Met?Lys?Lys?Ser?Asp?Ser?Arg?His?Asp?Phe

200 205 210

agc?ttt?tcc?ggt?ttg?aaa?acc?tcc?gtt?gcc?cgc?tac?gtg?gaa?gct?gcg 787

Ser?Phe?Ser?Gly?Leu?Lys?Thr?Ser?Val?Ala?Arg?Tyr?Val?Glu?Ala?Ala

215 220 225

gaa?aga?aac?ggt?gaa?gtt?att?tcc?gtg?gag?gac?gtc?tgc?gca?tca?ttc 835

Glu?Arg?Asn?Gly?Glu?Val?Ile?Ser?Val?Glu?Asp?Val?Cys?Ala?Ser?Phe

230 235 240 245

caa?gaa?gcg?gtg?tgt?gat?gtg?ttg?acg?ttt?aag?gcc?gtg?cgt?gcg?tgc 883

Gln?Glu?Ala?Val?Cys?Asp?Val?Leu?Thr?Phe?Lys?Ala?Val?Arg?Ala?Cys

250 255 260

cgc?gat?gtc?ggt?gcg?aag?gtg?ctg?ctg?ttg?ggt?gga?gga?gtg?gct?gcc 931

Arg?Asp?Val?Gly?Ala?Lys?Val?Leu?Leu?Leu?Gly?Gly?Gly?Val?Ala?Ala

265 270 275

aac?tct?cgt?ctg?cgg?gag?ctt?gct?caa?gaa?cgt?tgc?gat?aaa?gcc?gac 979

Asn?Ser?Arg?Leu?Arg?Glu?Leu?Ala?Gln?Glu?Arg?Cys?Asp?Lys?Ala?Asp

280 285 290

atc?gaa?ctc?cgg?gtt?cct?cgt?ttc?aat?ttg?tgc?acc?gat?aat?ggt?gtc 1027

Ile?Glu?Leu?Arg?Val?Pro?Arg?Phe?Asn?Leu?Cys?Thr?Asp?Asn?Gly?Val

295 300 305

atg?att?gca?gcg?ttg?gcg?gct?caa?aga?atc?cac?gaa?ggt?gcc?caa?gaa 1075

Met?Ile?Ala?Ala?Leu?Ala?Ala?Gln?Arg?Ile?His?Glu?Gly?Ala?Gln?Glu

310 315 320 325

tca?cca?att?tcg?gtc?gga?act?gat?cct?tct?ttg?tcc?gtt?gag?acc?cca 1123

Ser?Pro?Ile?Ser?Val?Gly?Thr?Asp?Pro?Ser?Leu?Ser?Val?Glu?Thr?Pro

330 335 340

cag?gtg?ttt?taaacattta?gtattagttc?cat 1155

Gln?Val?Phe

<210>148

<211>344

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>148

Met?Ile?Val?Leu?Gly?Ile?Glu?Ser?Ser?Cys?Asp?Glu?Thr?Gly?Val?Gly

1 5 10 15

Val?Val?Lys?Leu?Asp?Gly?Glu?Gly?Asn?Leu?Glu?Ile?Leu?Ala?Asp?Ser

20 25 30

Val?Ala?Ser?Ser?Met?Gln?Glu?His?Ala?Arg?Phe?Gly?Gly?Val?Val?Pro

35 40 45

Glu?Ile?Ala?Ser?Arg?Ala?His?Leu?Glu?Ser?Met?Val?Pro?Val?Met?Arg

50 55 60

Glu?Ala?Leu?Arg?Gln?Ala?Gly?Val?Asp?Arg?Pro?Asp?Ala?Val?Ala?Ala

65 70 75 80

Thr?Val?Gly?Pro?Gly?Leu?Ala?Gly?Ala?Leu?Leu?Val?Gly?Ala?Ser?Ala

85 90 95

Ala?Lys?Ala?Tyr?Ala?Ala?Ala?Trp?Gly?Val?Pro?Phe?Tyr?Ala?Val?Asn

100 105 110

His?Leu?Gly?Gly?His?Val?Ala?Val?Ala?Asn?Leu?Glu?Gly?Glu?Thr?Leu

115 120 125

Pro?His?Ala?Val?Ala?Leu?Leu?Val?Ser?Gly?Gly?His?Thr?Gln?Leu?Leu

130 135 140

Glu?Val?Asp?Ala?Val?Gly?Leu?Pro?Met?Lys?Glu?Leu?Gly?Ser?Thr?Leu

145 150 155 160

Asp?Asp?Ala?Ala?Gly?Glu?Ala?Tyr?Asp?Lys?Val?Ser?Arg?Leu?Leu?Gly

165 170 175

Leu?Gly?Tyr?Pro?Gly?Gly?Pro?Ile?Ile?Asp?Lys?Leu?Ala?Arg?Arg?Gly

180 185 190

Asn?Pro?Glu?Ala?Ile?Ala?Phe?Pro?Arg?Gly?Leu?Met?Lys?Lys?Ser?Asp

195 200 205

Ser?Arg?His?Asp?Phe?Ser?Phe?Ser?Gly?Leu?Lys?Thr?Ser?Val?Ala?Arg

210 215 220

Tyr?Val?Glu?Ala?Ala?Glu?Arg?Asn?Gly?Glu?Val?Ile?Ser?Val?Glu?Asp

225 230 235 240

Val?Cys?Ala?Ser?Phe?Gln?Glu?Ala?Val?Cys?Asp?Val?Leu?Thr?Phe?Lys

245 250 255

Ala?Val?Arg?Ala?Cys?Arg?Asp?Val?Gly?Ala?Lys?Val?Leu?Leu?Leu?Gly

260 265 270

Gly?Gly?Val?Ala?Ala?Asn?Ser?Arg?Leu?Arg?Glu?Leu?Ala?Gln?Glu?Arg

275 280 285

Cys?Asp?Lys?Ala?Asp?Ile?Glu?Leu?Arg?Val?Pro?Arg?Phe?Asn?Leu?Cys

290 295 300

Thr?Asp?Asn?Gly?Val?Met?Ile?Ala?Ala?Leu?Ala?Ala?Gln?Arg?Ile?His

305 310 315 320

Glu?Gly?Ala?Gln?Glu?Ser?Pro?Ile?Ser?Val?Gly?Thr?Asp?Pro?Ser?Leu

325 330 335

Ser?Val?Glu?Thr?Pro?Gln?Val?Phe

340

<210>149

<211>888

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(865)

<223>RXN02589

<400>149

gcctaaattg?cagcgagagg?tctaaaaggt?agtgctctag?ggattcatcc?aaactcacga?60

atattgaagt?tttaaagttg?aacaggaaaa?ataacaaata?atg?tct?att?tct?gat 115

Met?Ser?Ile?Ser?Asp

1 5

aat?tcc?cgc?gat?caa?tta?gga?gaa?ctg?cca?gct?ggt?cgg?cct?ctc?caa 163

Asn?Ser?Arg?Asp?Gln?Leu?Gly?Glu?Leu?Pro?Ala?Gly?Arg?Pro?Leu?Gln

10 15 20

tcc?gat?ttt?gat?aat?gac?ctc?gac?tac?cca?cgt?cta?ggc?agt?gtc?acg 211

Ser?Asp?Phe?Asp?Asn?Asp?Leu?Asp?Tyr?Pro?Arg?Leu?Gly?Ser?Val?Thr

25 30 35

ttt?agg?cgt?ggc?acc?ctc?act?gaa?aac?cag?caa?acc?atg?tgg?gat?gaa 259

Phe?Arg?Arg?Gly?Thr?Leu?Thr?Glu?Asn?Gln?Gln?Thr?Met?Trp?Asp?Glu

40 45 50

aag?tgg?cct?gaa?ctg?ggt?cgc?gtc?ctc?gaa?gat?gag?ctg?att?gat?gtt 307

Lys?Trp?Pro?Glu?Leu?Gly?Arg?Val?Leu?Glu?Asp?Glu?Leu?Ile?Asp?Val

55 60 65

gat?gcg?tgg?ttc?ggg?cgc?gaa?ggc?gca?aaa?acc?atc?gta?gag?atc?ggc 355

Asp?Ala?Trp?Phe?Gly?Arg?Glu?Gly?Ala?Lys?Thr?Ile?Val?Glu?Ile?Gly

70 75 80 85

tct?ggc?act?gga?act?tcg?act?gct?gcc?atg?gct?cca?ctt?gag?gct?gat 403

Ser?Gly?Thr?Gly?Thr?Ser?Thr?Ala?Ala?Met?Ala?Pro?Leu?Glu?Ala?Asp

90 95 100

acc?aac?att?gtc?gcc?gtc?gaa?cta?tac?aag?ccg?ggc?ttg?gcc?aag?ttg 451

Thr?Asn?Ile?Val?Ala?Val?Glu?Leu?Tyr?Lys?Pro?Gly?Leu?Ala?Lys?Leu

105 110 115

atg?ggc?tct?gtt?gtc?cgt?gga?gag?atc?gac?aac?gtg?cgc?atg?gtc?cgc 499

Met?Gly?Ser?Val?Val?Arg?Gly?Glu?Ile?Asp?Asn?Val?Arg?Met?Val?Arg

120 125 130

gga?gac?ggc?atc?gag?gtg?ctc?aac?cgc?atg?ttt?gcc?gat?ggg?tcc?ctg 547

Gly?Asp?Gly?Ile?Glu?Val?Leu?Asn?Arg?Met?Phe?Ala?Asp?Gly?Ser?Leu

135 140 145

gac?ggc?atc?cgc?gta?tac?ttc?ccg?gac?cct?tgg?cca?aag?gcg?cgc?cac 595

Asp?Gly?Ile?Arg?Val?Tyr?Phe?Pro?Asp?Pro?Trp?Pro?Lys?Ala?Arg?His

150 155 160 165

aac?aag?cgc?cgc?atc?atc?cag?tct?ggt?ccg?ctg?aac?ctg?ttt?gca?aag 643

Asn?Lys?Arg?Arg?Ile?Ile?Gln?Ser?Gly?Pro?Leu?Asn?Leu?Phe?Ala?Lys

170 175 180

aag?ctc?aag?cca?ggt?gga?gtt?ctg?cac?gtt?gct?acc?gac?cac?gct?gat 691

Lys?Leu?Lys?Pro?Gly?Gly?Val?Leu?His?Val?Ala?Thr?Asp?His?Ala?Asp

185 190 195

tac?gca?gag?tgg?atc?aat?gag?cta?gtt?gag?gtc?gaa?cca?ctg?ctt?gag 739

Tyr?Ala?Glu?Trp?Ile?Asn?Glu?Leu?Val?Glu?Val?Glu?Pro?Leu?Leu?Glu

200 205 210

tac?aaa?ggc?tgg?cca?tgg?gag?gaa?tgc?cct?cag?ctg?act?gac?cgt?cag 787

Tyr?Lys?Gly?Trp?Pro?Trp?Glu?Glu?Cys?Pro?Gln?Leu?Thr?Asp?Arg?Gln

215 220 225

gtc?atc?acc?aag?ttt?gaa?ggc?aaa?ggc?ttg?gaa?aaa?gat?cac?gtg?atc 835

Val?Ile?Thr?Lys?Phe?Glu?Gly?Lys?Gly?Leu?Glu?Lys?Asp?His?Val?Ile

230 235 240 245

aat?gag?tac?ttg?tgg?cag?aag?gtg?caa?aac?taatgtctga?tgtgcatgag 885

Asn?Glu?Tyr?Leu?Trp?Gln?Lys?Val?Gln?Asn

250 255

gtc 888

<210>150

<211>255

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>150

Met?Ser?Ile?Ser?Asp?Asn?Ser?Arg?Asp?Gln?Leu?Gly?Glu?Leu?Pro?Ala

1 5 10 15

Gly?Arg?Pro?Leu?Gln?Ser?Asp?Phe?Asp?Asn?Asp?Leu?Asp?Tyr?Pro?Arg

20 25 30

Leu?Gly?Ser?Val?Thr?Phe?Arg?Arg?Gly?Thr?Leu?Thr?Glu?Asn?Gln?Gln

35 40 45

Thr?Met?Trp?Asp?Glu?Lys?Trp?Pro?Glu?Leu?Gly?Arg?Val?Leu?Glu?Asp

50 55 60

Glu?Leu?Ile?Asp?Val?Asp?Ala?Trp?Phe?Gly?Arg?Glu?Gly?Ala?Lys?Thr

65 70 75 80

Ile?Val?Glu?Ile?Gly?Ser?Gly?Thr?Gly?Thr?Ser?Thr?Ala?Ala?Met?Ala

85 90 95

Pro?Leu?Glu?Ala?Asp?Thr?Asn?Ile?Val?Ala?Val?Glu?Leu?Tyr?Lys?Pro

100 105 110

Gly?Leu?Ala?Lys?Leu?Met?Gly?Ser?Val?Val?Arg?Gly?Glu?Ile?Asp?Asn

115 120 125

Val?Arg?Met?Val?Arg?Gly?Asp?Gly?Ile?Glu?Val?Leu?Asn?Arg?Met?Phe

130 135 140

Ala?Asp?Gly?Ser?Leu?Asp?Gly?Ile?Arg?Val?Tyr?Phe?Pro?Asp?Pro?Trp

145 150 155 160

Pro?Lys?Ala?Arg?His?Asn?Lys?Arg?Arg?Ile?Ile?Gln?Ser?Gly?Pro?Leu

165 170 175

Asn?Leu?Phe?Ala?Lys?Lys?Leu?Lys?Pro?Gly?Gly?Val?Leu?His?Val?Ala

180 185 190

Thr?Asp?His?Ala?Asp?Tyr?Ala?Glu?Trp?Ile?Asn?Glu?Leu?Val?Glu?Val

195 200 205

Glu?Pro?Leu?Leu?Glu?Tyr?Lys?Gly?Trp?Pro?Trp?Glu?Glu?Cys?Pro?Gln

210 215 220

Leu?Thr?Asp?Arg?Gln?Val?Ile?Thr?Lys?Phe?Glu?Gly?Lys?Gly?Leu?Glu

225 230 235 240

Lys?Asp?His?Val?Ile?Asn?Glu?Tyr?Leu?Trp?Gln?Lys?Val?Gln?Asn

245 250 255

<210>l51

<211>888

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(865)

<223>FRXA02589

<400>151

gcctaaattg?cagcgagagg?tctaaaaggt?agtgctctag?ggattcatcc?aaactcacga?60

atattgaagt?tttaaagttg?aacaggaaaa?ataacaaata?atg?tct?att?tct?gat 115

Met?Ser?Ile?Ser?Asp

1 5

aat?tcc?cgc?gat?caa?tta?gga?gaa?ctg?cca?gct?ggt?cgg?cct?ctc?caa 163

Asn?Ser?Arg?Asp?Gln?Leu?Gly?Glu?Leu?Pro?Ala?Gly?Arg?Pro?Leu?Gln

10 15 20

tcc?gat?ttt?gat?aat?gac?ctc?gac?tac?cca?cgt?cta?ggc?agt?gtc?acg 211

Ser?Asp?Phe?Asp?Asn?Asp?Leu?Asp?Tyr?Pro?Arg?Leu?Gly?Ser?Val?Thr

25 30 35

ttt?agg?cgt?ggc?acc?ctc?act?gaa?aac?cag?caa?acc?atg?tgg?gat?gaa 259

Phe?Arg?Arg?Gly?Thr?Leu?Thr?Glu?Asn?Gln?Gln?Thr?Met?Trp?Asp?Glu

40 45 50

aag?tgg?cct?gaa?ctg?ggt?cgc?gtc?ctc?gaa?gat?gag?ctg?att?gat?gtt 307

Lys?Trp?Pro?Glu?Leu?Gly?Arg?Val?Leu?Glu?Asp?Glu?Leu?Ile?Asp?Val

55 60 65

gat?gcg?tgg?ttc?ggg?cgc?gaa?ggc?gca?aaa?acc?atc?gta?gag?atc?ggc 355

Asp?Ala?Trp?Phe?Gly?Arg?Glu?Gly?Ala?Lys?Thr?Ile?Val?Glu?Ile?Gly

70 75 80 85

tct?ggc?act?gga?act?tcg?act?gct?gcc?atg?gct?cca?ctt?gag?gct?gat 403

Ser?Gly?Thr?Gly?Thr?Ser?Thr?Ala?Ala?Met?Ala?Pro?Leu?Glu?Ala?Asp

90 95 100

acc?aac?att?gtc?gcc?gtc?gaa?cta?tac?aag?ccg?ggc?ttg?gcc?aag?ttg 451

Thr?Asn?Ile?Val?Ala?Val?Glu?Leu?Tyr?Lys?Pro?Gly?Leu?Ala?Lys?Leu

105 110 115

atg?ggc?tct?gtt?gtc?cgt?gga?gag?atc?gac?aac?gtg?cgc?atg?gtc?cgc 499

Met?Gly?Ser?Val?Val?Arg?Gly?Glu?Ile?Asp?Asn?Val?Arg?Met?Val?Arg

120 125 130

gga?gac?ggc?atc?gag?gtg?ctc?aac?cgc?atg?ttt?gcc?gat?ggg?tcc?ctg 547

Gly?Asp?Gly?Ile?Glu?Val?Leu?Asn?Arg?Met?Phe?Ala?Asp?Gly?Ser?Leu

135 140 145

gac?ggc?atc?cgc?gta?tacttc?ccg?gac?cct?tgg?cca?aag?gcg?cgc?cac 595

Asp?Gly?Ile?Arg?Val?Tyr?Phe?Pro?Asp?Pro?Trp?Pro?Lys?Ala?Arg?His

150 155 160 165

aac?aag?cgc?cgc?atc?atc?cag?tct?ggt?ccg?ctg?aac?ctg?ttt?gca?aag 643

Asn?Lys?Arg?Arg?Ile?Ile?Gln?Ser?Gly?Pro?Leu?Asn?Leu?Phe?Ala?Lys

170 175 180

aag?ctc?aag?cca?ggt?gga?gtt?ctg?cac?gtt?gct?acc?gac?cac?gct?gat 691

Lys?Leu?Lys?Pro?Gly?Gly?Val?Leu?His?Val?Ala?Thr?Asp?His?Ala?Asp

185 190 195

tac?gca?gag?tgg?atc?aat?gag?cta?gtt?gag?gtc?gaa?cca?ctg?ctt?gag 739

Tyr?Ala?Glu?Trp?Ile?Asn?Glu?Leu?Val?Glu?Val?Glu?Pro?Leu?Leu?Glu

200 205 210

tac?aaa?ggc?tgg?cca?tgg?gag?gaa?tgc?cct?cag?ctg?act?gac?cgt?cag 787

Tyr?Lys?Gly?Trp?Pro?Trp?Glu?Glu?Cys?Pro?Gln?Leu?Thr?Asp?Arg?Gln

215 220 225

gtc?atc?acc?aag?ttt?gaa?ggc?aaa?ggc?ttg?gaa?aaa?gat?cac?gtg?atc 835

Val?Ile?Thr?Lys?Phe?Glu?Gly?Lys?Gly?Leu?Glu?Lys?Asp?His?Val?Ile

230 235 240 245

aat?gag?tac?ttg?tgg?cag?aag?gtg?caa?aac?taatgtctga?tgtgcatgag 885

Asn?Glu?Tyr?Leu?Trp?Gln?Lys?Val?Gln?Asn

250 255

gtc 888

<210>152

<211>255

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>152

Met?Ser?Ile?Ser?Asp?Asn?Ser?Arg?Asp?Gln?Leu?Gly?Glu?Leu?Pro?Ala

1 5 10 15

Gly?Arg?Pro?Leu?Gln?Ser?Asp?Phe?Asp?Asn?Asp?Leu?Asp?Tyr?Pro?Arg

20 25 30

Leu?Gly?Ser?Val?Thr?Phe?Arg?Arg?Gly?Thr?Leu?Thr?Glu?Asn?Gln?Gln

35 40 45

Thr?Met?Trp?Asp?Glu?Lys?Trp?Pro?Glu?Leu?Gly?Arg?Val?Leu?Glu?Asp

50 55 60

Glu?Leu?Ile?Asp?Val?Asp?Ala?Trp?Phe?Gly?Arg?Glu?Gly?Ala?Lys?Thr

65 70 75 80

Ile?Val?Glu?Ile?Gly?Ser?Gly?Thr?Gly?Thr?Ser?Thr?Ala?Ala?Met?Ala

85 90 95

Pro?Leu?Glu?Ala?Asp?Thr?Asn?Ile?Val?Ala?Val?Glu?Leu?Tyr?Lys?Pro

100 105 110

Gly?Leu?Ala?Lys?Leu?Met?Gly?Ser?Val?Val?Arg?Gly?Glu?Ile?Asp?Asn

115 120 125

Val?Arg?Met?Val?Arg?Gly?Asp?Gly?Ile?Glu?Val?Leu?Asn?Arg?Met?Phe

130 135 140

Ala?Asp?Gly?Ser?Leu?Asp?Gly?Ile?Arg?Val?Tyr?Phe?Pro?Asp?Pro?Trp

145 150 155 160

Pro?Lys?Ala?Arg?His?Asn?Lys?Arg?Arg?Ile?Ile?Gln?Ser?Gly?Pro?Leu

165 170 175

Asn?Leu?Phe?Ala?Lys?Lys?Leu?Lys?Pro?Gly?Gly?Val?Leu?His?Val?Ala

180 185 190

Thr?Asp?His?Ala?Asp?Tyr?Ala?Glu?Trp?Ile?Asn?Glu?Leu?Val?Glu?Val

195 200 205

Glu?Pro?Leu?Leu?Glu?Tyr?Lys?Gly?Trp?Pro?Trp?Glu?Glu?Cys?Pro?Gln

210 215 220

Leu?Thr?Asp?Arg?Gln?Val?Ile?Thr?Lys?Phe?Glu?Gly?Lys?Gly?Leu?Glu

225 230 235 240

Lys?Asp?His?Val?Ile?Asn?Glu?Tyr?Leu?Trp?Gln?Lys?Val?Gln?Asn

245 250 255

<210>153

<211>948

<212>DNA

＜21 3〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(925)

<223>RXA00226

<400>153

ccgcctgcgg?tgtcagcgga?gcgcgcccgg?cgtctgaaaa?ctgcacttgg?tgagaacgtg?60

attgttcatg?atgtcacctg?ttccatcggt?acggaggggc?atg?aac?tta?tcg?atg 115

Met?Asn?Leu?Ser?Met

1 5

ccg?gcc?ttc?gct?acc?tgg?gtt?ctg?atc?cta?gat?ttc?tca?cgc?acc?ctc 163

Pro?Ala?Phe?Ala?Thr?Trp?Val?Leu?Ile?Leu?Asp?Phe?Ser?Arg?Thr?Leu

10 15 20

atg?gca?gcc?cac?aat?ctc?cag?ggc?aaa?aac?gcc?ctg?att?ttc?cgc?gcc 211

Met?Ala?Ala?His?Asn?Leu?Gln?Gly?Lys?Asn?Ala?Leu?Ile?Phe?Arg?Ala

25 30 35

gac?gcg?ctc?cag?ccc?gca?agc?agg?gga?gcc?gac?gtc?atc?atc?gcg?gac 259

Asp?Ala?Leu?Gln?Pro?Ala?Ser?Arg?Gly?Ala?Asp?Val?Ile?Ile?Ala?Asp

40 45 50

cct?gcc?aga?cgc?gcc?ggg?ggc?aag?cgc?att?aca?aat?ccg?gca?cag?ctc 307

Pro?Ala?Arg?Arg?Ala?Gly?Gly?Lys?Arg?Ile?Thr?Asn?Pro?Ala?Gln?Leu

55 60 65

ctg?cca?cct?ctg?cct?tcg?ctt?ctc?gac?gcc?tgg?atc?aac?caa?cca?ctc 355

Leu?Pro?Pro?Leu?Pro?Ser?Leu?Leu?Asp?Ala?Trp?Ile?Asn?Gln?Pro?Leu

70 75 80 85

gcc?gtt?aaa?tgt?gcc?ccc?ggc?ctt?gat?ttt?tcg?gaa?tgg?cca?ggt?ctc 403

Ala?Val?Lys?Cys?Ala?Pro?Gly?Leu?Asp?Phe?Ser?Glu?Trp?Pro?Gly?Leu

90 95 100

gtc?agt?att?gcc?agc?gtt?gat?gga?ggc?gtg?aaa?gaa?gca?tgc?ctc?tac 451

Val?Ser?Ile?Ala?Ser?Val?Asp?Gly?Gly?Val?Lys?Glu?Ala?Cys?Leu?Tyr

105 110 115

act?acg?gat?ctg?gca?gat?ggg?gaa?act?cgc?gaa?gct?atc?gtg?atc?aaa 499

Thr?Thr?Asp?Leu?Ala?Asp?Gly?Glu?Thr?Arg?Glu?Ala?Ile?Val?Ile?Lys

120 125 130

gat?ggg?ctc?att?gac?cgc?atc?acc?aac?ttt?gaa?gac?gat?gcc?acg?gga 547

Asp?Gly?Leu?Ile?Asp?Arg?Ile?Thr?Asn?Phe?Glu?Asp?Asp?Ala?Thr?Gly

135 140 145

caa?gac?ctt?gcg?gct?gca?cct?ggt?gag?ttc?atc?atc?gac?cca?gac?ggt 595

Gln?Asp?Leu?Ala?Ala?Ala?Pro?Gly?Glu?Phe?Ile?Ile?Asp?Pro?Asp?Gly

150 155 160 165

gcc?atc?gtg?cgc?gcc?ggg?ttg?gtt?cgc?cac?tat?gca?gtg?cgt?gag?cag 643

Ala?Ile?Val?Arg?Ala?Gly?Leu?Val?Arg?His?Tyr?Ala?Val?Arg?Glu?Gln

170 175 180

ctg?tgg?atg?ttg?gat?gag?cgg?atc?gca?tac?ctt?acg?ggc?aat?cgg?att 691

Leu?Trp?Met?Leu?Asp?Glu?Arg?Ile?Ala?Tyr?Leu?Thr?Gly?Asn?Arg?Ile

185 190 195

cca?gag?ggt?acc?agc?ggt?ttt?agg?ttt?att?gaa?gag?gtt?ccg?ctg?aag 739

Pro?Glu?Gly?Thr?Ser?Gly?Phe?Arg?Phe?Ile?Glu?Glu?Val?Pro?Leu?Lys

200 205 210

aag?ctg?aaa?tcg?gcg?atg?gca?gca?cat?gat?gcg?ggg?gcg?gtt?gaa?att 787

Lys?Leu?Lys?Ser?Ala?Met?Ala?Ala?His?Asp?Ala?Gly?Ala?Val?Glu?Ile

215 220 225

tta?gtg?cgt?ggt?gtt?gat?gtt?gat?cct?gat?cag?ttg?cgg?aaa?aga?ttg 835

Leu?Val?Arg?Gly?Val?Asp?Val?Asp?Pro?Asp?Gln?Leu?Arg?Lys?Arg?Leu

230 235 240 245

cag?ctg?aag?ggt?acc?aag?gcg?atg?tct?gtg?gtg?atc?act?cga?att?ggc 883

Gln?Leu?Lys?Gly?Thr?Lys?Ala?Met?Ser?Val?Val?Ile?Thr?Arg?Ile?Gly

250 255 260

agc?cga?ggg?gtt?gca?ttg?att?tgt?ggt?cct?cgc?gag?cgc?gcc 925

Ser?Arg?Gly?Val?Ala?Leu?Ile?Cys?Gly?Pro?Arg?Glu?Arg?Ala

265 270 275

taaagccgat?gcaaataaaa?ttg 948

<210>154

<211>275

<212>PRT

＜213〉Corynebacterium glutamicum (C0rynebacterium glutamicum)

<400>154

Met?Asn?Leu?Ser?Met?Pro?Ala?Phe?Ala?Thr?Trp?Val?Leu?Ile?Leu?Asp

1 5 10 15

Phe?Ser?Arg?Thr?Leu?Met?Ala?Ala?His?Asn?Leu?Gln?Gly?Lys?Asn?Ala

20 25 30

Leu?Ile?Phe?Arg?Ala?Asp?Ala?Leu?Gln?Pro?Ala?Ser?Arg?Gly?Ala?Asp

35 40 45

Val?Ile?Ile?Ala?Asp?Pro?Ala?Arg?Arg?Ala?Gly?Gly?Lys?Arg?Ile?Thr

50 55 60

Asn?Pro?Ala?Gln?Leu?Leu?Pro?Pro?Leu?Pro?Ser?Leu?Leu?Asp?Ala?Trp

65 70 75 80

Ile?Asn?Gln?Pro?Leu?Ala?Val?Lys?Cys?Ala?Pro?Gly?Leu?Asp?Phe?Ser

85 90 95

Glu?Trp?Pro?Gly?Leu?Val?Ser?Ile?Ala?Ser?Val?Asp?Gly?Gly?Val?Lys

100 105 110

Glu?Ala?Cys?Leu?Tyr?Thr?Thr?Asp?Leu?Ala?Asp?Gly?Glu?Thr?Arg?Glu

115 120 125

Ala?Ile?Val?lle?Lys?Asp?Gly?Leu?Ile?Asp?Arg?Ile?Thr?Asn?Phe?Glu

130 135 140

Asp?Asp?Ala?Thr?Gly?Gln?Asp?Leu?Ala?Ala?Ala?Pro?Gly?Glu?Phe?Ile

145 150 155 160

Ile?Asp?Pro?Asp?Gly?Ala?Ile?Val?Arg?Ala?Gly?Leu?Val?Arg?His?Tyr

165 170 175

Ala?Val?Arg?Glu?Gln?Leu?Trp?Met?Leu?Asp?Glu?Arg?Ile?Ala?Tyr?Leu

180 185 190

Thr?Gly?Asn?Arg?Ile?Pro?Glu?Gly?Thr?Ser?Gly?Phe?Arg?Phe?Ile?Glu

195 200 205

Glu?Val?Pro?Leu?Lys?Lys?Leu?Lys?Ser?Ala?Met?Ala?Ala?His?Asp?Ala

210 215 220

Gly?Ala?Val?Glu?Ile?Leu?Val?Arg?Gly?Val?Asp?Val?Asp?Pro?Asp?Gln

225 230 235 240

Leu?Arg?Lys?Arg?Leu?Gln?Leu?Lys?Gly?Thr?Lys?Ala?Met?Ser?Val?Val

245 250 255

Ile?Thr?Arg?Ile?Gly?Ser?Arg?Gly?Val?Ala?Leu?Ile?Cys?Gly?Pro?Arg

260 265 270

Glu?Arg?Ala

275

<210>155

<211>924

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(901)

<223>RXN01885

<400>155

gtggcgtcgc?agggatgttc?ctgcggcacc?atttttgctg?aggtggaact?cacggattaa?60

acacggattt?ttctaaggtt?aatcaagtaa?ggtttacctt?atg?act?acg?aaa?cct 115

Met?Thr?Thr?Lys?Pro

1 5

atc?atc?cca?gaa?tca?acc?cac?tcc?gca?gaa?cgt?gct?ggt?gga?cat?tgg 163

Ile?Ile?Pro?Glu?Ser?Thr?His?Ser?Ala?Glu?Arg?Ala?Gly?Gly?His?Trp

10 15 20

atc?ctt?gcc?agg?ctt?gga?aag?aaa?gtg?ctg?cgc?cct?gga?ggt?cgt?gaa 211

Ile?Leu?Ala?Arg?Leu?Gly?Lys?Lys?Val?Leu?Arg?Pro?Gly?Gly?Arg?Glu

25 30 35

aca?acg?cag?ttc?ctg?ctg?gag?aac?ctt?tct?ttg?acc?ggt?gct?acc?gtg 259

Thr?Thr?Gln?Phe?Leu?Leu?Glu?Asn?Leu?Ser?Leu?Thr?Gly?Ala?Thr?Val

40 45 50

gtg?gaa?ttt?gct?cca?gga?ctt?ggc?gtg?act?gca?cgt?gac?atc?ctt?ggc 307

Val?Glu?Phe?Ala?Pro?Gly?Leu?Gly?Val?Thr?Ala?Arg?Asp?Ile?Leu?Gly

55 60 65

aag?ggt?ccg?gct?cgc?tac?atc?gga?gtg?gat?agc?gac?gcg?gat?gca?tgc 355

Lys?Gly?Pro?Ala?Arg?Tyr?Ile?Gly?Val?Asp?Ser?Asp?Ala?Asp?Ala?Cys

70 75 80 85

gcg?aat?gta?cgt?gcg?atc?tta?cct?gct?ggt?cct?cac?gag?gtg?cgc?aat 403

Ala?Asn?Val?Arg?Ala?Ile?Leu?Pro?Ala?Gly?Pro?His?Glu?Val?Arg?Asn

90 95 100

aca?aat?gcc?acc?gat?act?ggc?ctt?gaa?agc?gac?tcg?ttt?gat?gtt?gtc 451

Thr?Asn?Ala?Thr?Asp?Thr?Gly?Leu?Glu?Ser?Asp?Ser?Phe?Asp?Val?Val

105 110 115

atc?ggc?gaa?gcg?atg?ttg?acc?atg?cag?acc?gat?aag?cac?aag?ttg?gag 499

Ile?Gly?Glu?Ala?Met?Leu?Thr?Met?Gln?Thr?Asp?Lys?His?Lys?Leu?Glu

120 125 130

ctg?atg?cgc?gag?gca?gct?cga?att?ctg?aaa?cca?ggc?ggg?ctg?tac?ggc 547

Leu?Met?Arg?Glu?Ala?Ala?Arg?Ile?Leu?Lys?Pro?Gly?Gly?Leu?Tyr?Gly

135 140 145

att?cac?gag?ctg?tcg?ctg?gtg?cct?gac?aat?gtc?tcc?act?gcg?gtg?aaa 595

Ile?His?Glu?Leu?Ser?Leu?Val?Pro?Asp?Asn?Val?Ser?Thr?Ala?Val?Lys

150 155 160 165

gag?gat?att?gct?aag?gcg?ctg?gct?cgt?tcc?atc?aaa?gtc?aat?gcc?cgc 643

Glu?Asp?Ile?Ala?Lys?Ala?Leu?Ala?Arg?Ser?Ile?Lys?Val?Asn?Ala?Arg

170 175 180

ccc?atc?acg?gtg?ccg?gaa?tgg?gct?gcg?ttg?gcg?cgt?gag?gca?ggg?ttc 691

Pro?Ile?Thr?Val?Pro?Glu?Trp?Ala?Ala?Leu?Ala?Arg?Glu?Ala?Gly?Phe

185 190 195

gat?gtg?att?aat?att?cgc?caa?gcc?gac?atg?gcc?ctt?cta?tcc?ctc?aag 739

Asp?Val?Ile?Asn?Ile?Arg?Gln?Ala?Asp?Met?Ala?Leu?Leu?Ser?Leu?Lys

200 205 210

cgg?aac?ctg?aag?gat?gaa?ggg?cta?aaa?ggt?gtc?ttc?acg?att?gtg?agg 787

Arg?Asn?Leu?Lys?Asp?Glu?Gly?Leu?Lys?Gly?Val?Phe?Thr?Ile?Val?Arg

215 220 225

aac?gtg?att?agc?caa?ccg?gat?ctg?cgc?aag?cga?gtg?ctc?gga?atg?cga 835

Asn?Val?Ile?Ser?Gln?Pro?Asp?Leu?Arg?Lys?Arg?Val?Leu?Gly?Met?Arg

230 235 240 245

aag?act?ttc?acc?gag?cat?aaa?gat?cac?tta?ggt?gcg?gtt?ggc?atc?att 883

Lys?Thr?Phe?Thr?Glu?His?Lys?Asp?His?Leu?Gly?Ala?Val?Gly?Ile?Ile

250 255 260

ttg?cag?aag?aga?gcc?caa?tagggatctg?aaatggaggg?gtg 924

Leu?Gln?Lys?Arg?Ala?Gln

265

<210>156

<211>267

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>156

Met?Thr?Thr?Lys?Pro?Ile?Ile?Pro?Glu?Ser?Thr?His?Ser?Ala?Glu?Arg

1 5 10 15

Ala?Gly?Gly?His?Trp?Ile?Leu?Ala?Arg?Leu?Gly?Lys?Lys?Val?Leu?Arg

20 25 30

Pro?Gly?Gly?Arg?Glu?Thr?Thr?Gln?Phe?Leu?Leu?Glu?Asn?Leu?Ser?Leu

35 40 45

Thr?Gly?Ala?Thr?Val?Val?Glu?Phe?Ala?Pro?Gly?Leu?Gly?Val?Thr?Ala

50 55 60

Arg?Asp?Ile?Leu?Gly?Lys?Gly?Pro?Ala?Arg?Tyr?Ile?Gly?Val?Asp?Ser

65 70 7580

Asp?Ala?Asp?Ala?Cys?Ala?Asn?Val?Arg?Ala?Ile?Leu?Pro?Ala?Gly?Pro

85 90 95

His?Glu?Val?Arg?Asn?Thr?Asn?Ala?Thr?Asp?Thr?Gly?Leu?Glu?Ser?Asp

100 105 110

Ser?Phe?Asp?Val?Val?Ile?Gly?Glu?Ala?Met?Leu?Thr?Met?Gln?Thr?Asp

115 120 125

Lys?His?Lys?Leu?Glu?Leu?Met?Arg?Glu?Ala?Ala?Arg?Ile?Leu?Lys?Pro

130 135 140

Gly?Gly?Leu?Tyr?Gly?Ile?His?Glu?Leu?Ser?Leu?Val?Pro?Asp?Asn?Val

145 150 155 160

Ser?Thr?Ala?Val?Lys?Glu?Asp?Ile?Ala?Lys?Ala?Leu?Ala?Arg?Ser?Ile

165 170 175

Lys?Val?Asn?Ala?Arg?Pro?Ile?Thr?Val?Pro?Glu?Trp?Ala?Ala?Leu?Ala

180 185 190

Arg?Glu?Ala?Gly?Phe?Asp?Val?Ile?Asn?Ile?Arg?Gln?Ala?Asp?Met?Ala

195 200 205

Leu?Leu?Ser?Leu?Lys?Arg?Asn?Leu?Lys?Asp?Glu?Gly?Leu?Lys?Gly?Val

210 215 220

Phe?Thr?Ile?Val?Arg?Asn?Val?Ile?Ser?Gln?Pro?Asp?Leu?Arg?Lys?Arg

225 230 235 240

Val?Leu?Gly?Met?Arg?Lys?Thr?Phe?Thr?Glu?His?Lys?Asp?His?Leu?Gly

245 250 255

Ala?Val?Gly?Ile?Ile?Leu?Gln?Lys?Arg?Ala?Gln

260 265

<210>157

<211>924

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(901)

<223>FRXA01885

<400>157

gtggcgtcgc?agggatgttc?ctgcggcacc?atttttgctg?aggtggaact?cacggattaa?60

acacggattt?ttctaaggtt?aatcaagtaa?ggtttacctt?atg?act?acg?aaa?cct 115

Met?Thr?Thr?Lys?Pro

1 5

atc?atc?cca?gaa?tca?acc?cac?tcc?gca?gaa?cgt?gct?ggt?gga?cat?tgg 163

Ile?Ile?Pro?G1u?Ser?Thr?His?Ser?Ala?Glu?Arg?Ala?Gly?Gly?His?Trp

10 15 20

atc?ctt?gcc?agg?ctt?gga?aag?aaa?gtg?ctg?cgc?cct?gga?ggt?cgt?gaa 211

Ile?Leu?Ala?Arg?Leu?Gly?Lys?Lys?Val?Leu?Arg?Pro?Gly?Gly?Arg?Glu

25 30 35

aca?acg?cag?ttc?ctg?ctg?gag?aac?ctt?tct?ttg?acc?ggt?gct?acc?gtg 259

Thr?Thr?Gln?Phe?Leu?Leu?Glu?Asn?Leu?Ser?Leu?Thr?Gly?Ala?Thr?Val

40 45 50

gtg?gaa?ttt?gct?cca?gga?ctt?ggc?gtg?act?gca?cgt?gac?atc?ctt?ggc 307

Val?Glu?Phe?Ala?Pro?Gly?Leu?Gly?Val?Thr?Ala?Arg?Asp?Ile?Leu?Gly

55 60 65

aag?ggt?ccg?gct?cgc?tac?atc?gga?gtg?gat?agc?gac?gcg?gat?gca?tgc 355

Lys?Gly?Pro?Ala?Arg?Tyr?Ile?Gly?Val?Asp?Ser?Asp?Ala?Asp?Ala?Cys

70 75 80 85

gcg?aat?gta?cgt?gcg?atc?tta?cct?gct?ggt?cct?cac?gag?gtg?cgc?aat 403

Ala?Asn?Val?Arg?Ala?Ile?Leu?Pro?Ala?Gly?Pro?His?Glu?Val?Arg?Asn

90 95 100

aca?aat?gcc?acc?gat?act?ggc?ctt?gaa?agc?gac?tcg?ttt?gat?gtt?gtc 451

Thr?Asn?Ala?Thr?Asp?Thr?Gly?Leu?Glu?Ser?Asp?Ser?Phe?Asp?Val?Val

105 110 115

atc?ggc?gaa?gcg?atg?ttg?acc?atg?cag?acc?gat?aag?cac?aag?ttg?gag 499

Ile?Gly?Glu?Ala?Met?Leu?Thr?Met?Gln?Thr?Asp?Lys?His?Lys?Leu?Glu

120 125 130

ctg?atg?cgc?gag?gca?gct?cga?att?ctg?aaa?cca?ggc?ggg?ctg?tac?ggc 547

Leu?Met?Arg?Glu?Ala?Ala?Arg?Ile?Leu?Lys?Pro?Gly?Gly?Leu?Tyr?Gly

135 140 145

att?cac?gag?ctg?tcg?ctg?gtg?cct?gac?aat?gtc?tcc?act?gcg?gtg?aaa 595

Ile?His?Glu?Leu?Ser?Leu?Val?Pro?Asp?Asn?Val?Ser?Thr?Ala?Val?Lys

150 155 160 165

gag?gat?att?gct?aag?gcg?ctg?gct?cgt?tcc?atc?aaa?gtc?aat?gcc?cgc 643

Glu?Asp?Ile?Ala?Lys?Ala?Leu?Ala?Arg?Ser?Ile?Lys?Val?Asn?Ala?Arg

170 175 180

ccc?atc?acg?gtg?ccg?gaa?tgg?gct?gcg?ttg?gcg?cgt?gag?gca?ggg?ttc 691

Pro?Ile?Thr?Val?Pro?Glu?Trp?Ala?Ala?Leu?Ala?Arg?Glu?Ala?Gly?Phe

185 190 195

gat?gtg?att?aat?att?cgc?caa?gcc?gac?atg?gcc?ctt?cta?tcc?ctc?aag 739

Asp?Val?Ile?Asn?Ile?Arg?Gln?Ala?Asp?Met?Ala?Leu?Leu?Ser?Leu?Lys

200 205 210

cgg?aac?ctg?aag?gat?gaa?ggg?cta?aaa?ggt?gtc?ttc?acg?att?gtg?agg 787

Arg?Asn?Leu?Lys?Asp?Glu?Gly?Leu?Lys?Gly?Val?Phe?Thr?Ile?Val?Arg

215 220 225

aac?gtg?att?agc?caa?ccg?gat?ctg?cgc?aag?cga?gtg?ctc?gga?atg?cga 835

Asn?Val?Ile?Ser?Gln?Pro?Asp?Leu?Arg?Lys?Arg?Val?Leu?Gly?Met?Arg

230 235 240 245

aag?act?ttc?acc?gag?cat?aaa?gat?cac?tta?ggt?gcg?gtt?ggc?atc?att 883

Lys?Thr?Phe?Thr?Glu?His?Lys?Asp?His?Leu?Gly?Ala?Val?Gly?Ile?Ile

250 255 260

ttg?cag?aag?aga?gcc?caa?tagggatctg?aaatggaggg?gtg 924

Leu?Gln?Lys?Arg?Ala?Gln

265

<210>158

<211>267

<212>PRT

＜2l 3〉Corynebacterium glutamicum (C0rynebacterium glutamicum)

<400>158

Met?Thr?Thr?Lys?Pro?Ile?Ile?Pro?Glu?Ser?Thr?His?Ser?Ala?Glu?Arg

1 5 10 15

Ala?Gly?Gly?His?Trp?Ile?Leu?Ala?Arg?Leu?Gly?Lys?Lys?Val?Leu?Arg

20 25 30

Pro?Gly?Gly?Arg?Glu?Thr?Thr?Gln?Phe?Leu?Leu?Glu?Asn?Leu?Ser?Leu

35 40 45

Thr?Gly?Ala?Thr?Val?Val?Glu?Phe?Ala?Pro?Gly?Leu?Gly?Val?Thr?Ala

50 55 60

Arg?Asp?Ile?Leu?Gly?Lys?Gly?Pro?Ala?Arg?Tyr?Ile?Gly?Val?Asp?Ser

65 70 75 80

Asp?Ala?Asp?Ala?Cys?Ala?Asn?Val?Arg?Ala?Ile?Leu?Pro?Ala?Gly?Pro

85 90 95

His?Glu?Val?Arg?Asn?Thr?Asn?Ala?Thr?Asp?Thr?Gly?Leu?Glu?Ser?Asp

100 105 110

Ser?Phe?Asp?Val?Val?Ile?Gly?Glu?Ala?Met?Leu?Thr?Met?Gln?Thr?Asp

115 120 125

Lys?His?Lys?Leu?Glu?Leu?Met?Arg?Glu?Ala?Ala?Arg?Ile?Leu?Lys?Pro

130 135 140

Gly?Gly?Leu?Tyr?Gly?Ile?His?Glu?Leu?Ser?Leu?Val?Pro?Asp?Asn?Val

145 150 155 160

Ser?Thr?Ala?Val?Lys?Glu?Asp?Ile?Ala?Lys?Ala?Leu?Ala?Arg?Ser?Ile

165 170 175

Lys?Val?Asn?Ala?Arg?Pro?Ile?Thr?Val?Pro?Glu?Trp?Ala?Ala?Leu?Ala

180 185 190

Arg?Glu?Ala?Gly?Phe?Asp?Val?Ile?Asn?Ile?Arg?Gln?Ala?Asp?Met?Ala

195 200 205

Leu?Leu?Ser?Leu?Lys?Arg?Asn?Leu?Lys?Asp?Glu?Gly?Leu?Lys?Gly?Val

210 215 220

Phe?Thr?Ile?Val?Arg?Asn?Val?Ile?Ser?Gln?Pro?Asp?Leu?Arg?Lys?Arg

225 230 235 240

Val?Leu?Gly?Met?Arg?Lys?Thr?Phe?Thr?Glu?His?Lys?Asp?His?Leu?Gly

245 250 255

Ala?Val?Gly?Ile?Ile?Leu?Gln?Lys?Arg?Ala?Gln

260 265

<210>159

<211>894

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(871)

<223>RXA02592

<400>159

aaacaccacc?attgtttcct?ccatcgacga?tgccatcacc?accattttgc?gatggatgaa?60

cggcgaagac?atccgcgacc?tcaactggac?ccgcgcataa?atg?gcc?tca?ttt?ccg 115

Met?Ala?Ser?Phe?Pro

1 5

gag?ctt?ccg?gct?ctt?cgt?cgc?ttg?gct?acc?ttg?ggc?agg?tcg?tgg?ggt 163

Glu?Leu?Pro?Ala?Leu?Arg?Arg?Leu?Ala?Thr?Leu?Gly?Arg?Ser?Trp?Gly

10 15 20

tta?ctg?tct?gat?ttc?aaa?tac?gaa?caa?acc?cga?cct?gac?atc?ttt?tac 211

Leu?Leu?Ser?Asp?Phe?Lys?Tyr?Glu?Gln?Thr?Arg?Pro?Asp?Ile?Phe?Tyr

25 30 35

gga?aac?ctg?gcc?ctc?gat?acc?tcg?agt?ctg?gtg?gcg?gct?ttg?tct?gaa 259

Gly?Asn?Leu?Ala?Leu?Asp?Thr?Ser?Ser?Leu?Val?Ala?Ala?Leu?Ser?Glu

40 45 50

gat?att?tct?ggc?gcc?gga?tta?aat?gac?ctg?aaa?gtt?ctc?gac?gtc?ggc 307

Asp?Ile?Ser?Gly?Ala?Gly?Leu?Asn?Asp?Leu?Lys?Val?Leu?Asp?Val?Gly

55 60 65

ggc?gga?ccc?gga?tacttc?gcc?gaa?gcc?ttt?gag?aca?ctg?ggc?gcc?acc 355

Gly?Gly?Pro?Gly?Tyr?Phe?Ala?Glu?Ala?Phe?Glu?Thr?Leu?Gly?Ala?Thr

70 75 80 85

tacttc?tcc?gtc?gaa?ccc?gac?gtt?ggc?gaa?atg?tcc?gca?gct?ggc?atc 403

Tyr?Phe?Ser?Val?Glu?Pro?Asp?Val?Gly?Glu?Met?Ser?Ala?Ala?Gly?Ile

90 95 100

gac?gtc?cac?gga?tca?gtc?cgc?gga?tcc?ggc?ctc?gac?ctg?ccg?ttt?ctt 451

Asp?Val?His?Gly?Ser?Val?Arg?Gly?Ser?Gly?Leu?Asp?Leu?Pro?Phe?Leu

105 110 115

ccc?gat?tcc?ttt?gac?gtg?gtg?tac?tcc?tcc?aac?gtt?gca?gaa?cat?gtc 499

Pro?Asp?Ser?Phe?Asp?Val?Val?Tyr?Ser?Ser?Asn?Val?Ala?Glu?His?Val

120 125 130

tcc?gca?ccg?tgg?gaa?ttg?gga?gaa?gaa?atg?ctc?cgc?gtc?acc?cgc?agc 547

Ser?Ala?Pro?Trp?Glu?Leu?Gly?Glu?Glu?Met?Leu?Arg?Val?Thr?Arg?Ser

135 140 145

ggc?ggc?ctg?gca?atc?ctg?agc?tac?acc?att?tgg?tta?ggg?ccc?ttc?ggc 595

Gly?Gly?Leu?Ala?Ile?Leu?Ser?Tyr?Thr?Ile?Trp?Leu?Gly?Pro?Phe?Gly

150 155 160 165

ggc?cat?gaa?acc?gga?ctg?tgg?gaa?cac?tac?gtt?ggc?gga?gaa?ttt?gcc 643

Gly?His?Glu?Thr?Gly?Leu?Trp?Glu?His?Tyr?Val?Gly?Gly?Glu?Phe?Ala

170 175 180

cgc?gat?cgc?tac?acg?aag?aaa?cac?ggg?cac?ccg?cct?aag?aac?gtt?ttc 691

Arg?Asp?Arg?Tyr?Thr?Lys?Lys?His?Gly?His?Pro?Pro?Lys?Asn?Val?Phe

185 190 195

ggg?gag?tca?ctg?ttt?aat?gtg?tcc?tgc?cgg?gag?ggg?ctg?gaa?tgg?gga 739

Gly?Glu?Ser?Leu?Phe?Asn?Val?Ser?Cys?Arg?Glu?Gly?Leu?Glu?Trp?Gly

200 205 210

gcc?tcc?gtg?ggc?aat?gcg?gaa?ttg?gtt?gcc?gct?ttt?ccc?cgc?tac?cac 787

Ala?Ser?Val?Gly?Asn?Ala?Glu?Leu?Val?Ala?Ala?Phe?Pro?Arg?Tyr?His

215 220 225

ccg?tat?tgg?gtc?tgg?tgg?atg?gtt?aaa?gtc?cca?gtg?ctc?cga?gaa?ttc 835

Pro?Tyr?Trp?Val?Trp?Trp?Met?Val?Lys?Val?Pro?Val?Leu?Arg?Glu?Phe

230 235 240 245

gcg?gta?agt?aac?ttg?gtg?ttg?gtg?ttt?aaa?aag?cac?tgaggttttg 881

Ala?Val?Ser?Asn?Leu?Val?Leu?Val?phe?Lys?Lys?His

250 255

aggaattcat?cgc 894

<210>160

<211>257

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>160

Met?Ala?Ser?Phe?Pro?Glu?Leu?Pro?Ala?Leu?Arg?Arg?Leu?Ala?Thr?Leu

1 5 10 15

Gly?Arg?Ser?Trp?Gly?Leu?Leu?Ser?Asp?Phe?Lys?Tyr?Glu?Gln?Thr?Arg

20 25 30

Pro?Asp?Ile?Phe?Tyr?Gly?Asn?Leu?Ala?Leu?Asp?Thr?Ser?Ser?Leu?Val

35 40 45

Ala?Ala?Leu?Ser?Glu?Asp?Ile?Ser?Gly?Ala?Gly?Leu?Asn?Asp?Leu?Lys

50 55 60

Val?Leu?Asp?Val?Gly?Gly?Gly?Pro?Gly?Tyr?Phe?Ala?Glu?Ala?Phe?Glu

65 70 75 80

Thr?Leu?Gly?Ala?Thr?Tyr?Phe?Ser?Val?Glu?Pro?Asp?Val?Gly?Glu?Met

85 90 95

Ser?Ala?Ala?Gly?Ile?Asp?Val?His?Gly?Ser?Val?Arg?Gly?Ser?Gly?Leu

100 105 110

Asp?Leu?Pro?Phe?Leu?Pro?Asp?Ser?Phe?Asp?Val?Val?Tyr?Ser?Ser?Asn

115 120 125

Val?Ala?Glu?His?Val?Ser?Ala?Pro?Trp?Glu?Leu?Gly?Glu?Glu?Met?Leu

130 135 140

Arg?Val?Thr?Arg?Ser?Gly?Gly?Leu?Ala?Ile?Leu?Ser?Tyr?Thr?Ile?Trp

145 150 155 160

Leu?Gly?Pro?Phe?Gly?Gly?His?Glu?Thr?Gly?Leu?Trp?Glu?His?Tyr?Val

165 170 175

Gly?Gly?Glu?Phe?Ala?Arg?Asp?Arg?Tyr?Thr?Lys?Lys?His?Gly?His?Pro

180 185 190

Pro?Lys?Asn?Val?Phe?Gly?Glu?Ser?Leu?Phe?Asn?Val?Ser?Cys?Arg?Glu

195 200 205

Gly?Leu?Glu?Trp?Gly?Ala?Ser?Val?Gly?Asn?Ala?Glu?Leu?Val?Ala?Ala

210 215 220

Phe?Pro?Arg?Tyr?His?Pro?Tyr?Trp?Val?Trp?Trp?Met?Val?Lys?Val?Pro

225 230 235 240

Val?Leu?Arg?Glu?Phe?Ala?Val?Ser?Asn?Leu?Val?Leu?Val?Phe?Lys?Lys

245 250 255

His

<210>161

<211>720

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(697)

<223>RXN01795

<400>161

agaccatatt?gaagacctcg?aagctgttga?gcctggctac?atcgtcaagc?ctcgcctgta?60

caacttcgct?gaatacggtg?tcccacaatt?ccgcgaacgt?gtg?ctc?att?gtt?ggc 115

Val?Leu?Ile?Val?Gly

1 5

att?cgc?cgt?gac?acc?ggc?ttt?gat?ttc?aag?cac?cca?gct?cct?acc?cat 163

Ile?Arg?Arg?Asp?Thr?Gly?Phe?Asp?Phe?Lys?His?Pro?Ala?Pro?Thr?His

10 15 20

ggc?cct?cgc?ggt?gac?atg?ccg?tat?aag?act?gcc?ggc?gaa?gcg?ctc?aaa 211

Gly?Pro?Arg?Gly?Asp?Met?Pro?Tyr?Lys?Thr?Ala?Gly?Glu?Ala?Leu?Lys

25 30 35

ggc?gtg?aag?gat?gtc?ccc?aca?aac?aac?aac?cac?atg?aag?atc?atg?cct 259

Gly?Val?Lys?Asp?Val?Pro?Thr?Asn?Asn?Asn?His?Met?Lys?Ile?Met?Pro

40 45 50

cgc?acc?gtt?gaa?gtg?ctt?aag?cgc?atc?cct?gag?ggc?gaa?aac?ttc?acc 307

Arg?Thr?Val?Glu?Val?Leu?Lys?Arg?Ile?Pro?Glu?Gly?Glu?Asn?Phe?Thr

55 60 65

gcg?atc?ccc?aaa?gat?gac?ccc?tac?tac?gtc?aag?ggc?atg?att?agt?cac 355

Ala?Ile?Pro?Lys?Asp?Asp?Pro?Tyr?Tyr?Val?Lys?Gly?Met?Ile?Ser?His

70 75 80 85

gtt?tac?cgt?cgc?ttg?cac?cgt?gat?gag?cca?tcc?aaa?acc?ctt?atc?gcc 403

Val?Tyr?Arg?Arg?Leu?His?Arg?Asp?Glu?Pro?Ser?Lys?Thr?Leu?Ile?Ala

90 95 100

ggt?ggc?ggc?ggg?ggt?aca?tgg?gga?tac?cat?tat?gaa?aaa?aat?cga?gca 451

Gly?Gly?Gly?Gly?Gly?Thr?Trp?Gly?Tyr?His?Tyr?Glu?Lys?Asn?Arg?Ala

105 110 115

ttg?acc?aac?cgc?gag?cgg?gct?aga?att?caa?tcg?ttc?ccc?gat?gac?ttt 499

Leu?Thr?Asn?Arg?Glu?Arg?Ala?Arg?Ile?Gln?Ser?Phe?Pro?Asp?Asp?Phe

120 125 130

gag?ttt?ttg?gga?tca?aac?acc?gaa?gtc?cgc?cgc?caa?atc?ggt?aat?gct 547

Glu?Phe?Leu?Gly?Ser?Asn?Thr?Glu?Val?Arg?Arg?Gln?Ile?Gly?Asn?Ala

135 140 145

gtt?cct?cct?gta?ggt?atg?cac?gct?gtg?ggt?gag?cga?ctg?atg?aac?ctg 595

Val?Pro?Pro?Val?Gly?Met?His?Ala?Val?Gly?Glu?Arg?Leu?Met?Asn?Leu

150 155 160 165

tac?acc?ggg?aat?tac?act?ccc?gtc?gat?cta?gag?gaa?cag?cac?gcg?tac 643

Tyr?Thr?Gly?Asn?Tyr?Thr?Pro?Val?Asp?Leu?Glu?Glu?Gln?His?Ala?Tyr

170 175 180

ctg?cag?acg?ctc?tcc?att?aag?gaa?cgt?ctc?gcg?ctg?gct?gat?cag?gaa 691

Leu?Gln?Thr?Leu?Ser?Ile?Lys?Glu?Arg?Leu?Ala?Leu?Ala?Asp?Gln?Glu

185 190 195

gct?gat?taagtagata?tatgaagccc?acc 720

Ala?Asp

<210>162

<211>199

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>162

Val?Leu?Ile?Val?Gly?Ile?Arg?Arg?Asp?Thr?Gly?Phe?Asp?Phe?Lys?His

1 5 10 15

Pro?Ala?Pro?Thr?His?Gly?Pro?Arg?Gly?Asp?Met?Pro?Tyr?Lys?Thr?Ala

20 25 30

Gly?Glu?Ala?Leu?Lys?Gly?Val?Lys?Asp?Val?Pro?Thr?Asn?Asn?Asn?His

35 40 45

Met?Lys?Ile?Met?Pro?Arg?Thr?Val?Glu?Val?Leu?Lys?Arg?Ile?Pro?Glu

50 55 60

Gly?Glu?Asn?Phe?Thr?Ala?Ile?Pro?Lys?Asp?Asp?Pro?Tyr?Tyr?Val?Lys

65 70 75 80

Gly?Met?Ile?Ser?His?Val?Tyr?Arg?Arg?Leu?His?Arg?Asp?Glu?Pro?Ser

85 90 95

Lys?Thr?Leu?Ile?Ala?Gly?Gly?Gly?Gly?Gly?Thr?Trp?Gly?Tyr?His?Tyr

100 105 110

Glu?Lys?Asn?Arg?Ala?Leu?Thr?Asn?Arg?Glu?Arg?Ala?Arg?Ile?Gln?Ser

115 120 125

Phe?Pro?Asp?Asp?Phe?Glu?Phe?Leu?Gly?Ser?Asn?Thr?Glu?Val?Arg?Arg

130 135 140

Gln?Ile?Gly?Asn?Ala?Val?Pro?Pro?Val?Gly?Met?His?Ala?Val?Gly?Glu

145 150 155 160

Arg?Leu?Met?Asn?Leu?Tyr?Thr?Gly?Asn?Tyr?Thr?Pro?Val?Asp?Leu?Glu

165 170 175

Glu?Gln?His?Ala?Tyr?Leu?Gln?Thr?Leu?Ser?Ile?Lys?Glu?Arg?Leu?Ala

180 185 190

Leu?Ala?Asp?Gln?Glu?Ala?Asp

195

<210>163

<211>535

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(535)

<223>FRXA01795

<400>163

agaccatatt?gaagacctcg?aagctgttga?gcctggctac?atcgtcaagc?ctcgcctgta?60

caacttcgct?gaatacggtg?tcccacaatt?ccgcgaacgt?gtg?ctc?att?gtt?ggc 115

Val?Leu?Ile?Val?Gly

1 5

att?cgc?cgt?gac?acc?ggc?ttt?gat?ttc?aag?cac?cca?gct?cct?acc?cat 163

Ile?Arg?Arg?Asp?Thr?Gly?Phe?Asp?Phe?Lys?His?Pro?Ala?Pro?Thr?His

10 15 20

ggc?cct?cgc?ggt?gac?atg?ccg?tat?aag?act?gcc?ggc?gaa?gcg?ctc?aaa 211

Gly?Pro?Arg?Gly?Asp?Met?Pro?Tyr?Lys?Thr?Ala?Gly?Glu?Ala?Leu?Lys

25 30 35

ggc?gtg?aag?gat?gtc?ccc?aca?aac?aac?aac?cac?atg?aag?atc?atg?cct 259

Gly?Val?Lys?Asp?Val?Pro?Thr?Asn?Asn?Asn?His?Met?Lys?Ile?Met?Pro

40 45 50

cgc?acc?gtt?gaa?gtg?ctt?aag?cgc?atc?cct?gag?ggc?gaa?aac?ttc?acc 307

Arg?Thr?Val?Glu?Val?Leu?Lys?Arg?Ile?Pro?Glu?Gly?Glu?Asn?Phe?Thr

55 60 65

gcg?atc?ccc?aaa?gat?gac?ccc?tac?tac?gtc?aag?ggc?atg?att?agt?cac 355

Ala?Ile?Pro?Lys?Asp?Asp?Pro?Tyr?Tyr?Val?Lys?Gly?Met?Ile?Ser?His

70 75 80 85

gtt?tac?cgt?cgc?ttg?cac?cgt?gat?gag?cca?tcc?aaa?acc?ctt?atc?gcc 403

Val?Tyr?Arg?Arg?Leu?His?Arg?Asp?Glu?Pro?Ser?Lys?Thr?Leu?Ile?Ala

90 95 100

ggt?ggc?ggc?ggg?ggt?aca?tgg?gga?tac?cat?tat?gaa?aaa?aat?cga?gca 451

Gly?Gly?Gly?Gly?Gly?Thr?Trp?Gly?Tyr?His?Tyr?Glu?Lys?Asn?Arg?Ala

105 110 115

ttg?acc?aac?cgc?gag?cgg?gct?aga?att?caa?tcg?ttc?ccc?gat?gac?ttt 499

Leu?Thr?Asn?Arg?Glu?Arg?Ala?Arg?Ile?Gln?Ser?Phe?Pro?Asp?Asp?Phe

120 125 130

gag?ttt?ttg?gga?tca?aac?acc?caa?gtc?cgc?cgc?caa 535

Glu?Phe?Leu?Gly?Ser?Asn?Thr?Gln?Val?Arg?Arg?Gln

135 140 145

<210>164

<211>145

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>164

Val?Leu?Ile?Val?Gly?Ile?Arg?Arg?Asp?Thr?Gly?Phe?Asp?Phe?Lys?His

1 5 10 15

Pro?Ala?Pro?Thr?His?Gly?Pro?Arg?Gly?Asp?Met?Pro?Tyr?Lys?Thr?Ala

20 25 30

Gly?Glu?Ala?Leu?Lys?Gly?Val?Lys?Asp?Val?Pro?Thr?Asn?Asn?Asn?His

35 40 45

Met?Lys?Ile?Met?Pro?Arg?Thr?Val?Glu?Val?Leu?Lys?Arg?Ile?Pro?Glu

50 55 60

Gly?Glu?Asn?Phe?Thr?Ala?Ile?Pro?Lys?Asp?Asp?Pro?Tyr?Tyr?Val?Lys

65 70 75 80

Gly?Met?Ile?Ser?His?Val?Tyr?Arg?Arg?Leu?His?Arg?Asp?Glu?Pro?Ser

85 90 95

Lys?Thr?Leu?Ile?Ala?Gly?Gly?Gly?Gly?Gly?Thr?Trp?Gly?Tyr?His?Tyr

100 105 110

Glu?Lys?Asn?Arg?Ala?Leu?Thr?Asn?Arg?Glu?Arg?Ala?Arg?Ile?Gln?Ser

115 120 125

Phe?Pro?Asp?Asp?Phe?Glu?Phe?Leu?Gly?Ser?Asn?Thr?Gln?Val?Arg?Arg

130 135 140

Gln

145

<210>165

<211>1614

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1591)

<223>RXA01214

<400>165

gttgatatga?tgtggggtgt?ttatgaaaat?ttgtttgagg?gagtgaaggc?gcatgttgtt?60

gccagagttg?aatcgtcgga?cttttttcaa?aggggccggg?gtg?ctg?gca?gca?acg 115

Val?Leu?Ala?Ala?Thr

1 5

gtg?gtg?ggt?gcg?cag?gtg?ctg?gtg?gcg?tgt?tcc?tca?gat?gat?gtg?cgt 163

Val?Val?Gly?Ala?Gln?Val?Leu?Val?Ala?Cys?Ser?Ser?Asp?Asp?Val?Arg

10 15 20

ggt?tat?ggg?gga?gag?ccg?cgg?acg?ttg?cct?att?cca?cca?gca?gat?tta 211

Gly?Tyr?Gly?Gly?Glu?Pro?Arg?Thr?Leu?Pro?Ile?Pro?Pro?Ala?Asp?Leu

25 30 35

ggt?acg?cgt?gag?gga?tct?agc?gtg?cac?ttt?gcc?ctg?gag?gct?cag?act 259

Gly?Thr?Arg?Glu?Gly?Ser?Ser?Val?His?Phe?Ala?Leu?Glu?Ala?Gln?Thr

40 45 50

ggg?gag?agt?cag?att?ttg?ccg?gat?gtc?aca?acg?aag?acg?tgg?ggt?ttc 307

Gly?Glu?Ser?Gln?Ile?Leu?Pro?Asp?Val?Thr?Thr?Lys?Thr?Trp?Gly?Phe

55 60 65

aat?ggc?act?cat?ttg?ggg?ccg?acg?ttg?gtg?gtg?aag?aaa?ggt?gat?gac 355

Asn?Gly?Thr?His?Leu?Gly?Pro?Thr?Leu?Val?Val?Lys?Lys?Gly?Asp?Asp

70 75 80 85

gtc?cac?gtt?gat?gtg?ata?aac?aat?ttg?gat?gaa?atg?acc?act?gtg?cac 403

Val?His?Val?Asp?Val?Ile?Asn?Asn?Leu?Asp?Glu?Met?Thr?Thr?Val?His

90 95 100

tgg?cat?ggc?atg?aag?ttg?ccg?gcg?att?gct?gat?ggt?ggt?ccg?cac?tca 451

Trp?His?Gly?Met?Lys?Leu?Pro?Ala?Ile?Ala?Asp?Gly?Gly?Pro?His?Ser

105 110 115

ccg?atc?ggg?cct?ggg?cag?acg?tgg?tca?cca?acg?tgg?act?gtg?gcc?aat 499

Pro?Ile?Gly?Pro?Gly?Gln?Thr?Trp?Ser?Pro?Thr?Trp?Thr?Val?Ala?Asn

120 125 130

gat?gca?gcc?act?ttg?tgg?tac?cac?ccg?cac?act?cat?ggc?ctg?aca?ggt 547

Asp?Ala?Ala?Thr?Leu?Trp?Tyr?His?Pro?His?Thr?His?Gly?Leu?Thr?Gly

135 140 145

ttg?cat?gcg?tac?cgt?ggt?ttg?gcg?ggg?atg?atc?att?gtg?gaa?gat?gaa 595

Leu?His?Ala?Tyr?Arg?Gly?Leu?Ala?Gly?Met?Ile?Ile?Val?Glu?Asp?Glu

150 155 160 165

gca?aca?gac?aag?ctg?gat?ctg?cca?cgc?gag?tac?ggt?gtg?gac?gat?att 643

Ala?Thr?Asp?Lys?Leu?Asp?Leu?Pro?Arg?Glu?Tyr?Gly?Val?Asp?Asp?Ile

170 175 180

ccg?ctg?gtt?tta?atg?gat?cac?cgc?ttc?tta?gaa?gac?ggt?tcc?ctt?gat 691

Pro?Leu?Val?Leu?Met?Asp?His?Arg?Phe?Leu?Glu?Asp?Gly?Ser?Leu?Asp

185 190 195

gag?gaa?gac?ctc?ccc?gat?ctt?ggg?ctg?ttg?ggc?gat?acc?ccc?act?gcc 739

Glu?Glu?Asp?Leu?Pro?Asp?Leu?Gly?Leu?Leu?Gly?Asp?Thr?Pro?Thr?Ala

200 205 210

aat?ggc?att?acc?aat?gcg?cac?ttt?gat?gcc?acc?acg?cgc?cgg?gtt?cgg 787

Asn?Gly?Ile?Thr?Asn?Ala?His?Phe?Asp?Ala?Thr?Thr?Arg?Arg?Val?Arg

215 220 225

ttc?cgc?gtg?ctc?aac?ggc?tcc?aat?atg?cgg?ttc?tat?aac?ttg?gcg?ttt 835

Phe?Arg?Val?Leu?Asn?Gly?Ser?Asn?Met?Arg?Phe?Tyr?Asn?Leu?Ala?Phe

230 235 240 245

tca?gac?acg?cgc?acc?ttc?caa?gtc?att?gcc?agc?gat?tcc?ggt?ttg?ctg 883

Ser?Asp?Thr?Arg?Thr?Phe?Gln?Val?Ile?Ala?Ser?Asp?Ser?Gly?Leu?Leu

250 255 260

gat?gaa?cct?caa?gac?cgc?acc?acc?ttg?gct?att?ggc?cca?ggc?gag?cgg 931

Asp?Glu?Pro?Gln?Asp?Arg?Thr?Thr?Leu?Ala?Ile?Gly?Pro?Gly?Glu?Arg

265 270 275

tgg?gaa?atc?gtc?gtg?gag?cta?gag?ccc?ggc?gag?gac?gtc?acc?ttg?gaa 979

Trp?Glu?Ile?Val?Val?Glu?Leu?Glu?Pro?Gly?Glu?Asp?Val?Thr?Leu?Glu

280 285 290

tct?gta?ggt?ttt?gag?gac?aac?tac?ggc?gtc?cct?gat?gat?gag?ttc?gtg 1027

Ser?Val?Gly?Phe?Glu?Asp?Asn?Tyr?Gly?Val?Pro?Asp?Asp?Glu?Phe?Val

295 300 305

ccc?gat?ttc?ggc?atg?tca?gat?tcc?ttc?cag?ctg?ctc?acc?atc?acc?ggc 1075

Pro?Asp?Phe?Gly?Met?Ser?Asp?Ser?Phe?Gln?Leu?Leu?Thr?Ile?Thr?Gly

310 315 320 325

cct?tcc?gat?gat?gct?gcg?caa?gca?cct?gct?ttg?ccg?ggc?gtg?ctg?gtg 1123

Pro?Ser?Asp?Asp?Ala?Ala?Gln?Ala?Pro?Ala?Leu?Pro?Gly?Val?Leu?Val

330 335 340

aaa?tcc?acc?gaa?cct?gac?gtc?atc?gat?gcc?act?gaa?cgc?acc?ttc?atc 1171

Lys?Ser?Thr?Glu?Pro?Asp?Val?Ile?Asp?Ala?Thr?Glu?Arg?Thr?Phe?Ile

345 350 355

atg?aac?acc?ttc?tcc?atc?aac?gat?cta?cag?atg?gac?atg?cag?cgc?gtt 1219

Met?Asn?Thr?Phe?Ser?Ile?Asn?Asp?Leu?Gln?Met?Asp?Met?Gln?Arg?Val

360 365 370

gac?gtg?gtg?att?gac?cat?gac?cag?cca?gaa?gtg?tgg?att?gtc?acc?aac 1267

Asp?Val?Val?Ile?Asp?His?Asp?Gln?Pro?Glu?Val?Trp?Ile?Val?Thr?Asn

375 380 385

gac?aac?tcc?gac?tgg?ccc?cac?aac?ttc?cat?gtc?cac?gac?gcc?cgg?ttt 1315

Asp?Asn?Ser?Asp?Trp?Pro?His?Asn?Phe?His?Val?His?Asp?Ala?Arg?Phe

390 395 400 405

aag?gtg?ctg?aaa?ttt?gaa?ggc?acc?gac?gta?gag?ctc?ttc?aac?gac?ggc 1363

Lys?Val?Leu?Lys?Phe?Glu?Gly?Thr?Asp?Val?Glu?Leu?Phe?Asn?Asp?Gly

410 415 420

tgg?aaa?gac?acc?gtc?ggc?ctg?cca?ccg?gga?gca?acc?gca?act?tta?gcc 1411

Trp?Lys?Asp?Thr?Val?Gly?Leu?Pro?Pro?Gly?Ala?Thr?Ala?Thr?Leu?Ala

425 430 435

gtg?gaa?ttt?ggc?cac?tac?cca?gac?ccg?caa?tgg?ccc?tac?atg?tat?cac 1459

Val?Glu?Phe?Gly?His?Tyr?Pro?Asp?Pro?Gln?Trp?Pro?Tyr?Met?Tyr?His

440 445 450

tgc?cac?atg?ctc?tac?cac?gag?gat?caa?ggc?atg?atg?ggg?cag?ttc?gtc 1507

Cys?His?Met?Leu?Tyr?His?Glu?Asp?Gln?Gly?Met?Met?Gly?Gln?Phe?Val

455 460 465

atc?gtg?gag?cca?ggc?gac?gag?ccg?gcg?gcg?gtg?ctg?ggg?tcg?ggc?acg 1555

Ile?Val?Glu?Pro?Gly?Asp?Glu?Pro?Ala?Ala?Val?Leu?Gly?Ser?Gly?Thr

470 475 480 485

ggc?tcc?agc?att?gac?tcc?gcc?ggc?gga?cat?gcg?cac?taggggcgtg 1601

Gly?Ser?Ser?Ile?Asp?Ser?Ala?Gly?Gly?His?Ala?His

490 495

gggcggcgtc?gat 1614

<2l0>166

<211>497

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>166

Val?Leu?Ala?Ala?Thr?Val?Val?Gly?Ala?Gln?Val?Leu?Val?Ala?Cys?Ser

1 5 10 15

Ser?Asp?Asp?Val?Arg?Gly?Tyr?Gly?Gly?Glu?Pro?Arg?Thr?Leu?Pro?Ile

20 25 30

Pro?Pro?Ala?Asp?Leu?Gly?Thr?Arg?Glu?Gly?Ser?Ser?Val?His?Phe?Ala

35 40 45

Leu?Glu?Ala?Gln?Thr?Gly?Glu?Ser?Gln?Ile?Leu?Pro?Asp?Val?Thr?Thr

50 55 60

Lys?Thr?Trp?Gly?Phe?Asn?Gly?Thr?His?Leu?Gly?Pro?Thr?Leu?Val?Val

65 70 75 80

Lys?Lys?Gly?Asp?Asp?Val?His?Val?Asp?Val?Ile?Asn?Asn?Leu?Asp?Glu

85 90 95

Met?Thr?Thr?Val?His?Trp?His?Gly?Met?Lys?Leu?Pro?Ala?Ile?Ala?Asp

100 105 110

Gly?Gly?Pro?His?Ser?Pro?Ile?Gly?Pro?Gly?Gln?Thr?Trp?Ser?Pro?Thr

115 120 125

Trp?Thr?Val?Ala?Asn?Asp?Ala?Ala?Thr?Leu?Trp?Tyr?His?Pro?His?Thr

130 135 140

His?Gly?Leu?Thr?Gly?Leu?His?Ala?Tyr?Arg?Gly?Leu?Ala?Gly?Met?Ile

145 150 155 160

Ile?Val?Glu?Asp?Glu?Ala?Thr?Asp?Lys?Leu?Asp?Leu?Pro?Arg?Glu?Tyr

165 170 175

Gly?Val?Asp?Asp?Ile?Pro?Leu?Val?Leu?Met?Asp?His?Arg?Phe?Leu?Glu

180 185 190

Asp?Gly?Ser?Leu?Asp?Glu?Glu?Asp?Leu?Pro?Asp?Leu?Gly?Leu?Leu?Gly

195 200 205

Asp?Thr?Pro?Thr?Ala?Asn?Gly?Ile?Thr?Asn?Ala?His?Phe?Asp?Ala?Thr

210 215 220

Thr?Arg?Arg?Val?Arg?Phe?Arg?Val?Leu?Asn?Gly?Ser?Asn?Met?Arg?Phe

225 230 235 240

Tyr?Asn?Leu?Ala?Phe?Ser?Asp?Thr?Arg?Thr?Phe?Gln?Val?Ile?Ala?Ser

245 250 255

Asp?Ser?Gly?Leu?Leu?Asp?Glu?Pro?Gln?Asp?Arg?Thr?Thr?Leu?Ala?Ile

260 265 270

Gly?Pro?Gly?Glu?Arg?Trp?Glu?Ile?Val?Val?Glu?Leu?Glu?Pro?Gly?Glu

275 280 285

Asp?Val?Thr?Leu?Glu?Ser?Val?Gly?Phe?Glu?Asp?Asn?Tyr?Gly?Val?Pro

290 295 300

Asp?Asp?Glu?Phe?Val?Pro?Asp?Phe?Gly?Met?Ser?Asp?Ser?Phe?Gln?Leu

305 310 315 320

Leu?Thr?Ile?Thr?Gly?Pro?Ser?Asp?Asp?Ala?Ala?Gln?Ala?Pro?Ala?Leu

325 330 335

Pro?Gly?Val?Leu?Val?Lys?Ser?Thr?Glu?Pro?Asp?Val?Ile?Asp?Ala?Thr

340 345 350

Glu?Arg?Thr?Phe?Ile?Met?Asn?Thr?Phe?Ser?Ile?Asn?Asp?Leu?Gln?Met

355 360 365

Asp?Met?Gln?Arg?Val?Asp?Val?Val?Ile?Asp?His?Asp?Gln?Pro?Glu?Val

370 375 380

Trp?Ile?Val?Thr?Asn?Asp?Asn?Ser?Asp?Trp?Pro?His?Asn?Phe?His?Val

385 390 395 400

His?Asp?Ala?Arg?Phe?Lys?Val?Leu?Lys?Phe?Glu?Gly?Thr?Asp?Val?Glu

405 410 415

Leu?Phe?Asn?Asp?Gly?Trp?Lys?Asp?Thr?Val?Gly?Leu?Pro?Pro?Gly?Ala

420 425 430

Thr?Ala?Thr?Leu?Ala?Val?Glu?Phe?Gly?His?Tyr?Pro?Asp?Pro?Gln?Trp

435 440 445

Pro?Tyr?Met?Tyr?His?Cys?His?Met?Leu?Tyr?His?Glu?Asp?Gln?Gly?Met

450 455 460

Met?Gly?Gln?Phe?Val?Ile?Val?Glu?Pro?Gly?Asp?Glu?Pro?Ala?Ala?Val

465 470 475 480

Leu?Gly?Ser?Gly?Thr?Gly?Ser?Ser?Ile?Asp?Ser?Ala?Gly?Gly?His?Ala

485 490 495

His

<210>167

<211>588

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(588)

<223>RXA01250

<400>167

ctg?gat?atc?ggc?ggc?atc?gaa?gcc?aag?acg?tgg?gga?tac?gtc?tct?gac 48

Leu?Asp?Ile?Gly?Gly?Ile?Glu?Ala?Lys?Thr?Trp?Gly?Tyr?Val?Ser?Asp

1 5 10 15

acc?ggg?gat?gcg?gcc?att?gag?gcc?acc?gcc?ggc?gac?gtc?ctc?cag?gtc 96

Thr?Gly?Asp?Ala?Ala?Ile?Glu?Ala?Thr?Ala?Gly?Asp?Val?Leu?Gln?Val

20 25 30

gat?atc?acc?aat?gac?ctg?cct?gag?agc?acc?tcc?atc?cac?tgg?cat?ggc 144

Asp?Ile?Thr?Asn?Asp?Leu?Pro?Glu?Ser?Thr?Ser?Ile?His?Trp?His?Gly

35 40 45

atc?gca?ctc?cac?aac?gca?gcc?gac?ggt?gtg?ccc?ggc?atg?acc?cag?gac 192

Ile?Ala?Leu?His?Asn?Ala?Ala?Asp?Gly?Val?Pro?Gly?Met?Thr?Gln?Asp

50 55 60

ccc?att?gaa?cct?ggc?gag?tct?ttc?tcc?tat?gtt?ttt?gaa?gtc?ccc?cac 240

Pro?Ile?Glu?Pro?Gly?Glu?Ser?Phe?Ser?Tyr?Val?Phe?Glu?Val?Pro?His

65 70 75 80

ggt?ggc?acc?tac?ttc?tac?cat?tcc?cac?acc?ggc?ctg?cag?ctt?gat?cgc 288

Gly?Gly?Thr?Tyr?Phe?Tyr?His?Ser?His?Thr?Gly?Leu?Gln?Leu?Asp?Arg

85 90 95

ggc?ctc?cac?gcc?cca?ctg?atc?atc?cgt?gac?ccg?caa?gac?gct?gag?gac 336

Gly?Leu?His?Ala?Pro?Leu?Ile?Ile?Arg?Asp?Pro?Gln?Asp?Ala?Glu?Asp

100 105 110

cag?gac?gtc?gag?tgg?acc?atc?gtg?ctc?gac?gac?tgg?gtc?gat?ggc?att 384

Gln?Asp?Val?Glu?Trp?Thr?Ile?Val?Leu?Asp?Asp?Trp?Val?Asp?Gly?Ile

115 120 125

cag?ggc?act?ccc?gac?gat?gag?ctc?gac?aag?ctc?acc?gga?atg?ggt?tcg 432

Gln?Gly?Thr?Pro?Asp?Asp?Glu?Leu?Asp?Lys?Leu?Thr?Gly?Met?Gly?Ser

130 135 140

ggc?gac?cat?aac?ggg?agg?atg?gga?atg?gga?ggt?cac?ggc?cag?atg?atg 480

Gly?Asp?His?Asn?Gly?Arg?Met?Gly?Met?Gly?Gly?His?Gly?Gln?Met?Met

145 150 155 160

cac?ggc?acc?ccg?gac?cgg?gta?ctg?ggc?ggg?gat?gtc?ggc?gat?gtg?atg 528

His?Gly?Thr?Pro?Asp?Arg?Val?Leu?Gly?Gly?Asp?Val?Gly?Asp?Val?Met

165 170 175

tat?ccg?cac?tac?ctc?atc?aac?gga?cgt?atc?ccc?cgt?gct?cac?cgg?acc 576

Tyr?Pro?His?Tyr?Leu?Ile?Asn?Gly?Arg?Ile?Pro?Arg?Ala?His?Arg?Thr

180 185 190

ttc?gag?gct?cgc 588

Phe?Glu?Ala?Arg

195

<210>168

<211>196

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacteriumg glutamicum)

<400>168

Leu?Asp?Ile?Gly?Gly?Ile?Glu?Ala?Lys?Thr?Trp?Gly?Tyr?Val?Ser?Asp

1 5 10 15

Thr?Gly?Asp?Ala?Ala?Ile?Glu?Ala?Thr?Ala?Gly?Asp?Val?Leu?Gln?Val

20 25 30

Asp?Ile?Thr?Asn?Asp?Leu?Pro?Glu?Ser?Thr?Ser?Ile?His?Trp?His?Gly

35 40 45

Ile?Ala?Leu?His?Asn?Ala?Ala?Asp?Gly?Val?Pro?Gly?Met?Thr?Gln?Asp

50 55 60

Pro?Ile?Glu?Pro?Gly?Glu?Ser?Phe?Ser?Tyr?Val?Phe?Glu?Val?Pro?His

65 70 75 80

Gly?Gly?Thr?Tyr?Phe?Tyr?His?Ser?His?Thr?Gly?Leu?Gln?Leu?Asp?Arg

85 90 95

Gly?Leu?His?Ala?Pro?Leu?Ile?Ile?Arg?Asp?Pro?Gln?Asp?Ala?Glu?Asp

100 105 110

Gln?Asp?Val?Glu?Trp?Thr?Ile?Val?Leu?Asp?Asp?Trp?Val?Asp?Gly?Ile

115 120 125

Gln?Gly?Thr?Pro?Asp?Asp?Glu?Leu?Asp?Lys?Leu?Thr?Gly?Met?Gly?Ser

130 135 140

Gly?Asp?His?Asn?Gly?Arg?Met?Gly?Met?Gly?Gly?His?Gly?Gln?Met?Met

145 150 155 160

His?Gly?Thr?Pro?Asp?Arg?Val?Leu?Gly?Gly?Asp?Val?Gly?Asp?Val?Met

165 170 175

Tyr?Pro?His?Tyr?Leu?Ile?Asn?Gly?Arg?Ile?Pro?Arg?Ala?His?Arg?Thr

180 185 190

Phe?Glu?Ala?Arg

195

<210>169

<211>744

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(721)

<223>RXA02477

<400>169

cgagcagggc?tgtttgaaaa?gctgtaaatg?acatgaccta?aatgattgta?ctgactggca?60

ctttaggtca?tatgtcacac?cgagtggaat?aataaagctt?atg?cct?ttg?cgt?aat 115

Met?Pro?Leu?Arg?Asn

1 5

gtt?gat?aga?act?ccg?ccc?gca?gta?tgg?gaa?gca?ttg?ctt?gcc?gga?aac 163

Val?Asp?Arg?Thr?Pro?Pro?Ala?Val?Trp?Glu?Ala?Leu?Leu?Ala?Gly?Asn

10 15 20

gaa?aga?ttc?atc?agt?ttc?aac?gaa?gat?cga?cca?aac?cag?gac?gcc?ccg 211

Glu?Arg?Phe?Ile?Ser?Phe?Asn?Glu?Asp?Arg?Pro?Asn?Gln?Asp?Ala?Pro

25 30 35

cgc?aga?aga?gaa?ctt?cgc?aat?gga?caa?acg?cct?gca?gct?gtt?gtt?att 259

Arg?Arg?Arg?Glu?Leu?Arg?Asn?Gly?Gln?Thr?Pro?Ala?Ala?Val?Val?Ile

40 45 50

tcc?tgt?tca?gat?tct?cga?gtg?cca?gtt?gag?att?att?ttt?gac?gtc?ggt 307

Ser?Cys?Ser?Asp?Ser?Arg?Val?Pro?Val?G1u?Ile?Ile?Phe?Asp?Val?Gly

55 60 65

ctc?ggt?gac?ctc?ttt?gtt?gtc?cgt?act?gcc?gga?gaa?atc?ctc?gac?caa 355

Leu?Gly?Asp?Leu?Phe?Val?Val?Arg?Thr?Ala?Gly?Glu?Ile?Leu?Asp?Gln

70 75 80 85

gca?gtg?ctt?gcg?tcc?atc?gaa?tac?gcc?act?gaa?tcc?atc?ggc?gtt?cca 403

Ala?Val?Leu?Ala?Ser?Ile?Glu?Tyr?Ala?Thr?Glu?Ser?Ile?Gly?Val?Pro

90 95 100

ttg?gtt?atc?gtc?atg?ggc?cac?gaa?tcc?tgt?ggt?gca?gtt?gca?gca?act 451

Leu?Val?Ile?Val?Met?Gly?His?Glu?Ser?Cys?Gly?Ala?Val?Ala?Ala?Thr

105 110 115

gca?gca?gca?ctt?gaa?ggc?ggt?gca?ctt?ccc?gga?ggc?tac?caa?cga?gtt 499

Ala?Ala?Ala?Leu?Glu?Gly?Gly?Ala?Leu?Pro?Gly?Gly?Tyr?Gln?Arg?Val

120 125 130

ttg?gtt?gaa?aag?gtt?gca?cca?tcc?att?cta?gaa?gcc?aag?gca?gag?ggc 547

Leu?Val?Glu?Lys?Val?Ala?Pro?Ser?Ile?Leu?Glu?Ala?Lys?Ala?Glu?Gly

135 140 145

ctg?agc?tcc?atc?aag?gaa?ttc?gag?gaa?cac?cac?gtt?gtg?gca?acg?gta 595

Leu?Ser?Ser?Ile?Lys?Glu?Phe?Glu?Glu?His?His?Val?Val?Ala?Thr?Val

150 155 160 165

aac?caa?ctg?ttg?tcc?cgt?tct?cca?gag?att?cat?cag?aag?gtc?gaa?acc 643

Asn?Gln?Leu?Leu?Ser?Arg?Ser?Pro?Glu?Ile?His?Gln?Lys?Val?Glu?Thr

170 175 180

ggt?gag?ttg?gga?atc?att?ggt?ttg?cgc?tac?cga?ctc?tct?gac?ggt?cgt 691

Gly?Glu?Leu?Gly?Ile?Ile?Gly?Leu?Arg?Tyr?Arg?Leu?Ser?Asp?Gly?Arg

185 190 195

act?gaa?cct?gta?att?agc?aag?aac?gtg?ggt?tagttttcgg?tctgagattg 741

Thr?Glu?Pro?Val?Ile?Ser?Lys?Asn?Val?Gly

200 205

cct 744

<210>170

<211>207

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>170

Met?Pro?Leu?Arg?Asn?Val?Asp?Arg?Thr?Pro?Pro?Ala?Val?Trp?Glu?Ala

1 5 10 15

Leu?Leu?Ala?Gly?Asn?Glu?Arg?Phe?Ile?Ser?Phe?Asn?Glu?Asp?Arg?Pro

20 25 30

Asn?Gln?Asp?Ala?Pro?Arg?Arg?Arg?Glu?Leu?Arg?Asn?Gly?Gln?Thr?Pro

35 40 45

Ala?Ala?Val?Val?Ile?Ser?Cys?Ser?Asp?Ser?Arg?Val?Pro?Val?Glu?Ile

50 55 60

Ile?Phe?Asp?Val?Gly?Leu?Gly?Asp?Leu?Phe?Val?Val?Arg?Thr?Ala?Gly

65 70 75 80

Glu?Ile?Leu?Asp?Gln?Ala?Val?Leu?Ala?Ser?Ile?Glu?Tyr?Ala?Thr?Glu

85 90 95

Ser?Ile?Gly?Val?Pro?Leu?Val?Ile?Val?Met?Gly?His?Glu?Ser?Cys?Gly

100 105 110

Ala?Val?Ala?Ala?Thr?Ala?Ala?Ala?Leu?Glu?Gly?Gly?Ala?Leu?Pro?Gly

115 120 125

Gly?Tyr?Gln?Arg?Val?Leu?Val?Glu?Lys?Val?Ala?Pro?Ser?Ile?Leu?Glu

130 135 140

Ala?Lys?Ala?Glu?Gly?Leu?Ser?Ser?Ile?Lys?Glu?Phe?Glu?Glu?His?His

145 150 155 160

Val?Val?Ala?Thr?Val?Asn?Gln?Leu?Leu?Ser?Arg?Ser?Pro?Glu?Ile?His

165 170 175

Gln?Lys?Val?Glu?Thr?Gly?Glu?Leu?Gly?Ile?Ile?Gly?Leu?Arg?Tyr?Arg

180 185 190

Leu?Ser?Asp?Gly?Arg?Thr?Glu?Pro?Val?Ile?Ser?Lys?Asn?Val?Gly

195 200 205

<210>171

<211>618

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(595)

<223>RXN00833

<400>171

agctttttgc?atgtgtcata?tcgtaccgtt?tgcataggcc?tgttcgcgct?tggtgaacct?60

tttctagcac?caaaacaaaa?ctctccctag?tatggggtcc?atg?gct?aaa?aca?cat 115

Met?Ala?Lys?Thr?His

1 5

ttt?caa?ggc?aac?gaa?act?gct?acc?tcc?ggc?gaa?ctg?cca?cag?gtc?ggc 163

Phe?Gln?Gly?Asn?Glu?Thr?Ala?Thr?Ser?Gly?Glu?Leu?Pro?Gln?Val?Gly

10 15 20

gac?aac?ctc?gca?gag?ttc?aac?ctc?gtc?aac?acc?gaa?ctg?ggc?gag?gtc 211

Asp?Asn?Leu?Ala?Glu?Phe?Asn?Leu?Val?Asn?Thr?Glu?Leu?Gly?Glu?Val

25 30 35

tcc?tca?aag?gac?ttc?cag?ggc?cgc?aag?ctt?gtc?ctg?aac?atc?ttc?cca 259

Ser?Ser?Lys?Asp?Phe?Gln?Gly?Arg?Lys?Leu?Val?Leu?Asn?Ile?Phe?Pro

40 45 50

tcc?gtt?gac?acc?ggc?gtt?tgt?gca?aca?tca?gtc?cgc?aag?ttc?aac?gag 307

Ser?Val?Asp?Thr?Gly?Val?Cys?Ala?Thr?Ser?Val?Arg?Lys?Phe?Asn?Glu

55 60 65

gca?gca?gca?agc?ctg?gaa?aac?acc?acc?gtg?ctg?tgc?atc?tcc?aag?gat 355

Ala?Ala?Ala?Ser?Leu?Glu?Asn?Thr?Thr?Val?Leu?Cys?Ile?Ser?Lys?Asp

70 75 80 85

ctt?cca?ttc?gca?ctg?ggc?cgt?ttc?tgc?tcc?gca?gaa?ggc?atc?gag?aac 403

Leu?Pro?Phe?Ala?Leu?Gly?Arg?Phe?Cys?Ser?Ala?Glu?Gly?Ile?Glu?Asn

90 95 100

gtc?acc?cca?gta?tcc?gca?ttc?cgt?tcc?acc?ttc?ggt?gaa?gac?aac?ggc 451

Val?Thr?Pro?Val?Ser?Ala?Phe?Arg?Ser?Thr?Phe?Gly?Glu?Asp?Asn?Gly

105 110 115

atc?gtg?ctc?gaa?ggc?tca?cca?ctt?aag?ggt?ctt?ctt?gca?cgc?agc?gtc 499

Ile?Val?Leu?Glu?Gly?Ser?Pro?Leu?Lys?Gly?Leu?Leu?Ala?Arg?Ser?Val

120 125 130

atc?gtc?gtc?gat?gaa?aac?ggc?aag?gtt?gct?tac?acc?cag?ttg?gtt?gat 547

Ile?Val?Val?Asp?Glu?Asn?Gly?Lys?Val?Ala?Tyr?Thr?Gln?Leu?Val?Asp

135 140 145

gag?atc?ttc?act?gaa?cct?gat?tac?gac?gct?gca?ctt?gct?ggg?ctg?aac 595

Glu?Ile?Phe?Thr?Glu?Pro?Asp?Tyr?Asp?Ala?Ala?Leu?Ala?Gly?Leu?Asn

150 155 160 165

taatttactt?cgctcagggg?aat 618

<210>172

<211>165

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>172

Met?Ala?Lys?Thr?His?Phe?Gln?Gly?Asn?Glu?Thr?Ala?Thr?Ser?Gly?Glu

1 5 10 15

Leu?Pro?Gln?Val?Gly?Asp?Asn?Leu?Ala?Glu?Phe?Asn?Leu?Val?Asn?Thr

20 25 30

Glu?Leu?Gly?Glu?Val?Ser?Ser?Lys?Asp?Phe?Gln?Gly?Arg?Lys?Leu?Val

35 40 45

Leu?Asn?Ile?Phe?Pro?Ser?Val?Asp?Thr?Gly?Val?Cys?Ala?Thr?Ser?Val

50 55 60

Arg?Lys?Phe?Asn?Glu?Ala?Ala?Ala?Ser?Leu?Glu?Asn?Thr?Thr?Val?Leu

65 70 75 80

Cys?Ile?Ser?Lys?Asp?Leu?Pro?Phe?Ala?Leu?Gly?Arg?Phe?Cys?Ser?Ala

85 90 95

Glu?Gly?Ile?Glu?Asn?Val?Thr?Pro?Val?Ser?Ala?Phe?Arg?Ser?Thr?Phe

100 105 110

Gly?Glu?Asp?Asn?Gly?Ile?Val?Leu?Glu?Gly?Ser?Pro?Leu?Lys?Gly?Leu

115 120 125

Leu?Ala?Arg?Ser?Val?Ile?Val?Val?Asp?Glu?Asn?Gly?Lys?Val?Ala?Tyr

130 135 140

Thr?Gln?Leu?Val?Asp?Glu?Ile?Phe?Thr?Glu?Pro?Asp?Tyr?Asp?Ala?Ala

145 150 155 160

Leu?Ala?Gly?Leu?Asn

165

<210>173

<211>469

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(469)

<223>FRXA00833

<400>173

agctttttgc?atgtgtcata?tcgtaccgtt?tgcataggcc?tgttcgcgct?tggtgaacct?60

tttctagcac?caaaacaaaa?ctctccctag?tatggggtcc?atg?gct?aaa?aca?cat 115

Met?Ala?Lys?Thr?His

1 5

ttt?caa?ggc?aac?gaa?act?gct?acc?tcc?ggc?gaa?ctg?cca?cag?gtc?ggc 163

Phe?Gln?Gly?Asn?Glu?Thr?Ala?Thr?Ser?Gly?Glu?Leu?Pro?Gln?Val?Gly

10 15 20

gac?aac?ctc?gca?gag?ttc?aac?ctc?gtc?aac?acc?gaa?ctg?ggc?gag?gtc 211

Asp?Asn?Leu?Ala?Glu?Phe?Asn?Leu?Val?Asn?Thr?Glu?Leu?Gly?Glu?Val

25 30 35

tcc?tca?aag?gac?ttc?cag?ggc?cgc?aag?ctt?gtc?ctg?aac?atc?ttc?cca 259

Ser?Ser?Lys?Asp?Phe?Gln?Gly?Arg?Lys?Leu?Val?Leu?Asn?Ile?Phe?Pro

40 45 50

tcc?gtt?gac?acc?ggc?gtt?tgt?gca?aca?tca?gtc?cgc?aag?ttc?aac?gag 307

Ser?Val?Asp?Thr?Gly?Val?Cys?Ala?Thr?Ser?Val?Arg?Lys?Phe?Asn?Glu

55 60 65

gca?gca?gca?agc?ctg?gaa?aac?acc?acc?gtg?ctg?tgc?atc?tcc?aag?gat 355

Ala?Ala?Ala?Ser?Leu?Glu?Asn?Thr?Thr?Val?Leu?Cys?Ile?Ser?Lys?Asp

70 75 80 85

ctt?cca?ttc?gca?ctg?ggc?cgt?ttc?tgc?tcc?gca?gaa?ggc?atc?gag?aac 403

Leu?Pro?Phe?Ala?Leu?Gly?Arg?Phe?Cys?Ser?Ala?Glu?Gly?Ile?Glu?Asn

90 95 100

gtc?acc?cca?gta?tcc?gca?ttc?cgt?tcc?acc?ttc?ggt?gaa?gac?aac?ggc 451

Val?Thr?Pro?Val?Ser?Ala?Phe?Arg?Ser?Thr?Phe?Gly?Glu?Asp?Asn?Gly

105 110 115

atc?gtg?ctc?gaa?ggc?tca 469

Ile?Val?Leu?Glu?Gly?Ser

120

<210>174

<211>123

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>174

Met?Ala?Lys?Thr?His?Phe?Gln?Gly?Asn?Glu?Thr?Ala?Thr?Ser?Gly?Glu

1 5 10 15

Leu?Pro?Gln?Val?Gly?Asp?Asn?Leu?Ala?Glu?Phe?Asn?Leu?Val?Asn?Thr

20 25 30

Glu?Leu?Gly?Glu?Val?Ser?Ser?Lys?Asp?Phe?Gln?Gly?Arg?Lys?Leu?Val

35 40 45

Leu?Asn?Ile?Phe?Pro?Ser?Val?Asp?Thr?Gly?Val?Cys?Ala?Thr?Ser?Val

50 55 60

Arg?Lys?Phe?Asn?Glu?Ala?Ala?Ala?Ser?Leu?Glu?Asn?Thr?Thr?Val?Leu

65 70 75 80

Cys?Ile?Ser?Lys?Asp?Leu?Pro?Phe?Ala?Leu?Gly?Arg?Phe?Cys?Ser?Ala

85 90 95

Glu?Gly?Ile?Glu?Asn?Val?Thr?Pro?Val?Ser?Ala?Phe?Arg?Ser?Thr?Phe

100 105 110

Gly?Glu?Asp?Asn?Gly?Ile?Val?Leu?Glu?Gly?Ser

115 120

<210>175

<211>1146

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1123)

<223>RXA01224

<400>175

ttggcggcgg?gaagttcagg?cttgggggca?aacagtgctt?ggattttaga?caaaaaactc?60

acggaagtca?tcctatggca?ggcgcgccta?ggatggtgcc?atg?agc?atc?ctt?gac 115

Met?Ser?Ile?Leu?Asp

1 5

acg?ttg?aaa?act?ccc?gtg?att?gtc?gcc?ccg?atg?gct?ggc?ggc?ccg?tcc 163

Thr?Leu?Lys?Thr?Pro?Val?Ile?Val?Ala?Pro?Met?Ala?Gly?Gly?Pro?Ser

10 15 20

act?ccc?gcg?ttg?gtc?aat?gca?gca?gca?gag?gca?ggt?tcc?ctc?ggg?ttc 211

Thr?Pro?Ala?Leu?Val?Asn?Ala?Ala?Ala?Glu?Ala?Gly?Ser?Leu?Gly?Phe

25 30 35

ttg?gct?ggt?ggc?gtc?atg?cct?ctt?gag?cag?ctg?aaa?cag?gaa?ttg?tca 259

Leu?Ala?Gly?Gly?Val?Met?Pro?Leu?Glu?Gln?Leu?Lys?Gln?Glu?Leu?Ser

40 45 50

gag?gta?aaa?ggc?gtc?ttt?ggc?gtc?aac?ctg?ttt?cgc?ccg?cag?acg?gat 307

Glu?Val?Lys?Gly?Val?Phe?Gly?Val?Asn?Leu?Phe?Arg?Pro?Gln?Thr?Asp

55 60 65

gcg?cct?aag?cct?tca?gac?att?gat?gag?ctg?gcg?gga?ttg?ttg?tcc?tcg 355

Ala?Pro?Lys?Pro?Ser?Asp?Ile?Asp?Glu?Leu?Ala?Gly?Leu?Leu?Ser?Ser

70 75 80 85

gcg?ttt?cgg?caa?ttt?ggc?ctc?gat?gag?ccg?acg?gtg?cct?acg?ccg?gat 403

Ala?Phe?Arg?Gln?Phe?Gly?Leu?Asp?Glu?Pro?Thr?Val?Pro?Thr?Pro?Asp

90 95 100

ttg?agc?aat?ggg?tgg?gag?gct?aaa?ttt?gag?gcc?gtt?ctt?gcc?gct?aag 451

Leu?Ser?Asn?Gly?Trp?Glu?Ala?Lys?Phe?Glu?Ala?Val?Leu?Ala?Ala?Lys

105 110 115

ccc?gcc?gtt?ttt?tcc?tgc?acc?ttt?ggt?att?ttt?agc?gct?gaa?gaa?ttc 499

Pro?Ala?Val?Phe?Ser?Cys?Thr?Phe?Gly?Ile?Phe?Ser?Ala?Glu?Glu?Phe

120 125 130

gcc?cgg?atc?aaa?gcc?acc?gga?att?gag?gcg?tgg?gtg?acg?gtg?acc?aat 547

Ala?Arg?Ile?Lys?Ala?Thr?Gly?lle?Glu?Ala?Trp?Val?Thr?Val?Thr?Asn

135 140 145

ccg?gag?gac?gcg?ctg?gct?gcg?cag?aaa?gct?ggc?gcc?aac?gcg?ctt?gtc 595

Pro?Glu?Asp?Ala?Leu?Ala?Ala?Gln?Lys?Ala?Gly?Ala?Asn?Ala?Leu?Val

150 155 160 165

gtg?caa?ggc?ccc?gag?gcg?ggt?ggg?cac?cgc?tct?acc?tgg?tcc?att?gaa 643

Val?Gln?Gly?Pro?Glu?Ala?Gly?Gly?His?Arg?Ser?Thr?Trp?Ser?Ile?Glu

170 175 180

gtg?gag?ccg?gac?gag?cgc?gac?ctg?aaa?acc?ctc?ctc?gca?gct?gtc?aaa 691

Val?Glu?Pro?Asp?Glu?Arg?Asp?Leu?Lys?Thr?Leu?Leu?Ala?Ala?Val?Lys

185 190 195

caa?gcg?ggc?gtt?tac?ctc?ccg?ctc?atc?gca?gcc?ggc?ggc?ctt?tca?acc 739

Gln?Ala?Gly?Val?Tyr?Leu?Pro?Leu?Ile?Ala?Ala?Gly?Gly?Leu?Ser?Thr

200 205 210

tcc?gca?gac?gtg?gca?gca?att?tta?gaa?gcc?ggc?gcc?agc?gct?gcc?tcc 787

Ser?Ala?Asp?Val?Ala?Ala?Ile?Leu?Glu?Ala?Gly?Ala?Ser?Ala?Ala?Ser

215 220 225

tgt?ggt?tcc?gcc?ttt?ttg?ctt?agc?gac?gaa?gcc?ggc?acc?agc?tca?ctt 835

Cys?Gly?Ser?Ala?Phe?Leu?Leu?Ser?Asp?Glu?Ala?Gly?Thr?Ser?Ser?Leu

230 235 240 245

aac?cgc?gag?atc?ttg?gac?gcc?gcc?cca?gca?ctt?ggt?ttg?gaa?tcg?gtg 883

Asn?Arg?Glu?Ile?Leu?Asp?Ala?Ala?Pro?Ala?Leu?Gly?Leu?Glu?Ser?Val

250 255 260

tca?tct?cgc?gca?ttt?tcg?ggc?cgt?tat?gcc?agg?gga?gtg?gaa?acc?agg 931

Ser?Ser?Arg?Ala?Phe?Ser?Gly?Arg?Tyr?Ala?Arg?Gly?Val?Glu?Thr?Arg

265 270 275

ttc?acc?cgt?tcg?aac?gag?ggg?tta?ccc?ccg?ttg?tac?cca?tac?ctc?aac 979

phe?Thr?Arg?Ser?Asn?Glu?Gly?Leu?Pro?Pro?Leu?Tyr?Pro?Tyr?Leu?Asn

280 285 290

cca?atg?atc?aca?tct?tta?cgt?aag?gtg?gcg?gga?agt?gca?ggg?aac?tgg 1027

Pro?Met?Ile?Thr?Ser?Leu?Arg?Lys?Val?Ala?Gly?Ser?Ala?Gly?Asn?Trp

295 300 305

gat?tac?gcc?tac?tgc?ctg?gta?gga?gtc?ggc?ctg?gaa?tcg?att?gcg?aag 1075

Asp?Tyr?Ala?Tyr?Cys?Leu?Val?Gly?Val?Gly?Leu?Glu?Ser?Ile?Ala?Lys

310 315 320 325

ggt?agt?gca?aag?cag?ata?ctg?gaa?tca?tta?aca?cct?tcc?gct?ttg?ggc 1123

Gly?Ser?Ala?Lys?Gln?Ile?Leu?Glu?Ser?Leu?Thr?Pro?Ser?Ala?Leu?Gly

330 335 340

taatgttggg?gggagtgctt?tca 1146

<210>176

<211>341

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>176

Met?Ser?Ile?Leu?Asp?Thr?Leu?Lys?Thr?Pro?Val?Ile?Val?Ala?Pro?Met

1 5 10 15

Ala?Gly?Gly?Pro?Ser?Thr?Pro?Ala?Leu?Val?Asn?Ala?Ala?Ala?Glu?Ala

20 25 30

Gly?Ser?Leu?Gly?Phe?Leu?Ala?Gly?Gly?Val?Met?Pro?Leu?Glu?Gln?Leu

35 40 45

Lys?Gln?Glu?Leu?Ser?Glu?Val?Lys?Gly?Val?Phe?Gly?Val?Asn?Leu?Phe

50 55 60

Arg?Pro?Gln?Thr?Asp?Ala?Pro?Lys?Pro?Ser?Asp?Ile?Asp?Glu?Leu?Ala

65 70 75 80

Gly?Leu?Leu?Ser?Ser?Ala?Phe?Arg?Gln?Phe?Gly?Leu?Asp?Glu?Pro?Thr

85 90 95

Val?Pro?Thr?Pro?Asp?Leu?Ser?Asn?Gly?Trp?Glu?Ala?Lys?Phe?Glu?Ala

100 105 110

Val?Leu?Ala?Ala?Lys?Pro?Ala?Val?Phe?Ser?Cys?Thr?Phe?Gly?Ile?Phe

115 120 125

Ser?Ala?Glu?Glu?Phe?Ala?Arg?Ile?Lys?Ala?Thr?Gly?Ile?Glu?Ala?Trp

130 135 140

Val?Thr?Val?Thr?Asn?Pro?Glu?Asp?Ala?Leu?Ala?Ala?Gln?Lys?Ala?Gly

145 150 155 160

Ala?Asn?Ala?Leu?Val?Val?Gln?Gly?Pro?Glu?Ala?Gly?Gly?His?Arg?Ser

165 170 175

Thr?Trp?Ser?Ile?Glu?Val?Glu?Pro?Asp?Glu?Arg?Asp?Leu?Lys?Thr?Leu

180 185 190

Leu?Ala?Ala?Val?Lys?Gln?Ala?Gly?Val?Tyr?Leu?Pro?Leu?Ile?Ala?Ala

195 200 205

Gly?Gly?Leu?Ser?Thr?Ser?Ala?Asp?Val?Ala?Ala?Ile?Leu?Glu?Ala?Gly

210 215 220

Ala?Ser?Ala?Ala?Ser?Cys?Gly?Ser?Ala?Phe?Leu?Leu?Ser?Asp?Glu?Ala

225 230 235 240

Gly?Thr?Ser?Ser?Leu?Asn?Arg?Glu?Ile?Leu?Asp?Ala?Ala?Pro?Ala?Leu

245 250 255

Gly?Leu?Glu?Ser?Val?Ser?Ser?Arg?Ala?Phe?Ser?Gly?Arg?Tyr?Ala?Arg

260 265 270

Gly?Val?Glu?Thr?Arg?Phe?Thr?Arg?Ser?Asn?Glu?Gly?Leu?Pro?Pro?Leu

275 280 285

Tyr?Pro?Tyr?Leu?Asn?Pro?Met?Ile?Thr?Ser?Leu?Arg?Lys?Val?Ala?Gly

290 295 300

Ser?Ala?Gly?Asn?Trp?Asp?Tyr?Ala?Tyr?Cys?Leu?Val?Gly?Val?Gly?Leu

305 310 315 320

Glu?Ser?Ile?Ala?Lys?Gly?Ser?Ala?Lys?Gln?Ile?Leu?Glu?Ser?Leu?Thr

325 330 335

Pro?Ser?Ala?Leu?Gly

340

<210>177

<211>516

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(493)

<223>RXA01182

<400>177

gttaaaacgg?aaactaatac?cccaaaggat?accgattcaa?tttgtgatgt?gtggtgttcg 60

ggtcatatca?agctaaacag?atgcccccta?caataggctt?gtg?ttc?aat?tta?ttt 115

Val?Phe?Asn?Leu?Phe

1 5

ggt?cgt?aaa?act?cct?cgc?tct?aac?ctc?cgc?cca?cca?cgc?ggt?ccg?ggc 163

Gly?Arg?Lys?Thr?Pro?Arg?Ser?Asn?Leu?Arg?Pro?Pro?Arg?Gly?Pro?Gly

10 15 20

gat?act?gtg?cgc?ccg?gaa?gat?tta?aaa?ttc?ttg?atg?caa?tgg?gtg?cag 211

Asp?Thr?Val?Arg?Pro?Glu?Asp?Leu?Lys?Phe?Leu?Met?Gln?Trp?Val?Gln

25 30 35

gat?aag?cca?ttt?gtt?gag?gca?ttc?gtt?gaa?ccg?gaa?acg?ctg?gtc?aat 259

Asp?Lys?Pro?Phe?Val?Glu?Ala?Phe?Val?Glu?Pro?Glu?Thr?Leu?Val?Asn

40 45 50

gag?atg?tct?gtc?gtt?ttg?gtt?gat?gct?cat?ggg?gtt?ttt?gtc?cgc?cga 307

Glu?Met?Ser?Val?Val?Leu?Val?Asp?Ala?His?Gly?Val?Phe?Val?Arg?Arg

55 60 65

agg?atc?ggc?ggt?ccc?aaa?ggg?att?gat?gtt?atc?gcg?aaa?aag?ctc?ggc 355

Arg?Ile?Gly?Gly?Pro?Lys?Gly?Ile?Asp?Val?Ile?Ala?Lys?Lys?Leu?Gly

70 75 80 85

gtt?ccg?gtt?tat?gat?gtt?gag?gag?acc?ggt?tac?ccc?caa?agg?atg?cgc 403

Val?Pro?Val?Tyr?Asp?Val?Glu?Glu?Thr?Gly?Tyr?Pro?Gln?Arg?Met?Arg

90 95 100

gaa?cgc?att?gaa?tat?gag?cgc?atc?tta?aga?aag?cgt?gag?gaa?caa?aaa 451

Glu?Arg?Ile?Glu?Tyr?Glu?Arg?Ile?Leu?Arg?Lys?Arg?Glu?Glu?Gln?Lys

105 110 115

gct?cgc?cgc?gct?aaa?ttt?gag?cgc?ggc?gag?aat?cct?gat?ctt 493

Ala?Arg?Arg?Ala?Lys?Phe?Glu?Arg?Gly?Glu?Asn?Pro?Asp?Leu

120 125 130

taactagcgt?ttagctttcc?gac 516

<210>178

<211>131

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>178

Val?Phe?Asn?Leu?Phe?Gly?Arg?Lys?Thr?Pro?Arg?Ser?Asn?Leu?Arg?Pro

1 5 10 15

Pro?Arg?Gly?Pro?Gly?Asp?Thr?Val?Arg?Pro?Glu?Asp?Leu?Lys?Phe?Leu

20 25 30

Met?Gln?Trp?Val?Gln?Asp?Lys?Pro?Phe?Val?Glu?Ala?Phe?Val?Glu?Pro

35 40 45

Glu?Thr?Leu?Val?Asn?Glu?Met?Ser?Val?Val?Leu?Val?Asp?Ala?His?Gly

50 55 60

Val?Phe?Val?Arg?Arg?Arg?Ile?Gly?Gly?Pro?Lys?Gly?Ile?Asp?Val?Ile

65 70 75 80

Ala?Lys?Lys?Leu?Gly?Val?Pro?Val?Tyr?Asp?Val?Glu?Glu?Thr?Gly?Tyr

85 90 95

Pro?Gln?Arg?Met?Arg?Glu?Arg?Ile?Glu?Tyr?Glu?Arg?Ile?Leu?Arg?Lys

100 105 110

Arg?Glu?Glu?Gln?Lys?Ala?Arg?Arg?Ala?Lys?Phe?Glu?Arg?Gly?Glu?Asn

115 120 125

Pro?Asp?Leu

130

<210>179

<211>834

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(811)

<223>RXA02531

<400>179

cacttcgctc?cccaaggtac?atccccgatg?ccacttcttg?gagccatcat?cggtgccacc 60

aaacacattg?aagtgggcac?tggagtagtg?gatatgcgtt?atg?aaa?atc?cct?ttg 115

Met?Lys?Ile?Pro?Leu

1 5

tat?atg?gcc?gag?gaa?gca?gct?gct?ctc?aat?ctg?ctt?gcc?gac?ggc?cga 163

Tyr?Met?Ala?Glu?Glu?Ala?Ala?Ala?Leu?Asn?Leu?Leu?Ala?Asp?Gly?Arg

10 15 20

cta?gcc?ctc?gga?gtt?tcc?agg?gga?tca?ccc?gaa?cca?gcc?gag?aag?ggt 211

Leu?Ala?Leu?Gly?Val?Ser?Arg?Gly?Ser?Pro?Glu?Pro?Ala?Glu?Lys?Gly

25 30 35

tgg?gaa?gct?ttc?ggc?tac?gac?ggc?ggt?gat?gat?cct?aaa?gct?gca?ggc 259

Trp?Glu?Ala?Phe?Gly?Tyr?Asp?Gly?Gly?Asp?Asp?Pro?Lys?Ala?Ala?Gly

40 45 50

atg?gca?cgg?gag?aaa?ttc?ctt?cgc?ttc?ctc?gat?gcc?atc?gat?ggt?cgc 307

Met?Ala?Arg?Glu?Lys?Phe?Leu?Arg?Phe?Leu?Asp?Ala?Ile?Asp?Gly?Arg

55 60 65

ccc?atg?tcc?atc?gct?tcc?gag?aat?caa?tac?cca?cgc?ctc?tac?cat?ccg 355

Pro?Met?Ser?Ile?Ala?Ser?Glu?Asn?Gln?Tyr?Pro?Arg?Leu?Tyr?His?Pro

70 75 80 85

ggc?act?ccc?ctg?ccg?atc?ttc?ccg?cat?gat?ctt?gac?ttg?ggt?aaa?tcc 403

Gly?Thr?Pro?Leu?Pro?Ile?Phe?Pro?His?Asp?Leu?Asp?Leu?Gly?Lys?Ser

90 95 100

att?tgg?tgg?ggc?gcc?ggt?tcc?cac?aac?acc?gcc?gaa?caa?gca?gca?cgc 451

Ile?Trp?Trp?Gly?Ala?Gly?Ser?His?Asn?Thr?Ala?Glu?Gln?Ala?Ala?Arg

105 110 115

gat?ggc?gtt?aac?ttg?atg?agc?tcc?acc?ctc?gtc?gcc?gaa?gcc?acc?ggc 499

Asp?Gly?Val?Asn?Leu?Met?Ser?Ser?Thr?Leu?Val?Ala?Glu?Ala?Thr?Gly

120 125 130

caa?tcc?ttc?ggg?gat?ctg?caa?gcc?gat?caa?atc?gcg?ttc?tac?cgc?caa 547

Gln?Ser?Phe?Gly?Asp?Leu?Gln?Ala?Asp?Gln?Ile?Ala?Phe?Tyr?Arg?Gln

135 140 145

gct?tgg?aaa?gaa?gcc?gga?cac?gat?tgg?acc?cca?cgt?gtg?tct?gtc?tcc 595

Ala?Trp?Lys?Glu?Ala?Gly?His?Asp?Trp?Thr?Pro?Arg?Val?Ser?Val?Ser

150 155 160 165

agg?tcc?atc?ttt?ccg?atc?gtc?acc?gac?cgc?gac?cgt?gag?ctt?ttc?gga 643

Arg?Ser?Ile?Phe?Pro?Ile?Val?Thr?Asp?Arg?Asp?Arg?Glu?Leu?Phe?Gly

170 175 180

ctt?cag?gga?caa?ggc?ggt?gac?caa?gta?gga?atc?ctg?gat?gat?acc?cga 691

Leu?Gln?Gly?Gln?Gly?Gly?Asp?Gln?Val?Gly?Ile?Leu?Asp?Asp?Thr?Arg

185 190 195

tcc?acg?ttc?ggt?cgc?agc?tac?gcc?gga?agt?ccc?gat?gaa?ctc?atc?gac 739

Ser?Thr?Phe?Gly?Arg?Ser?Tyr?Ala?Gly?Ser?Pro?Asp?Glu?Leu?Ile?Asp

200 205 210

cag?ctc?caa?gga?aga?caa?agc?tgt?gat?gga?agc?cga?cac?ctt?gat?gct 787

Gln?Leu?Gln?Gly?Arg?Gln?Ser?Cys?Asp?Gly?Ser?Arg?His?Leu?Asp?Ala

215 220 225

cac?cgc?ccc?caa?cca?aat?ggg?tgt?tgagatcaac?gcgtcgatcc?tga 834

His?Arg?Pro?Gln?Pro?Asn?Gly?Cys

230 235

<210>180

<211>237

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>180

Met?Lys?Ile?Pro?Leu?Tyr?Met?Ala?Glu?Glu?Ala?Ala?Ala?Leu?Asn?Leu

1 5 10 15

Leu?Ala?Asp?Gly?Arg?Leu?Ala?Leu?Gly?Val?Ser?Arg?Gly?Ser?Pro?Glu

20 25 30

Pro?Ala?Glu?Lys?Gly?Trp?Glu?Ala?Phe?Gly?Tyr?Asp?Gly?Gly?Asp?Asp

35 40 45

Pro?Lys?Ala?Ala?Gly?Met?Ala?Arg?Glu?Lys?Phe?Leu?Arg?Phe?Leu?Asp

50 55 60

Ala?Ile?Asp?Gly?Arg?Pro?Met?Ser?Ile?Ala?Ser?Glu?Asn?Gln?Tyr?Pro

65 70 75 80

Arg?Leu?Tyr?His?Pro?Gly?Thr?Pro?Leu?Pro?Ile?Phe?Pro?His?Asp?Leu

85 90 95

Asp?Leu?Gly?Lys?Ser?Ile?Trp?Trp?Gly?Ala?Gly?Ser?His?Asn?Thr?Ala

100 105 110

Glu?Gln?Ala?Ala?Arg?Asp?Gly?Val?Asn?Leu?Met?Ser?Ser?Thr?Leu?Val

115 120 125

Ala?Glu?Ala?Thr?Gly?Gln?Ser?Phe?Gly?Asp?Leu?Gln?Ala?Asp?Gln?Ile

130 135 140

Ala?Phe?Tyr?Arg?Gln?Ala?Trp?Lys?Glu?Ala?Gly?His?Asp?Trp?Thr?Pro

145 150 155 160

Arg?Val?Ser?Val?Ser?Arg?Ser?Ile?Phe?Pro?Ile?Val?Thr?Asp?Arg?Asp

165 170 175

Arg?Glu?Leu?Phe?Gly?Leu?Gln?Gly?Gln?Gly?Gly?Asp?Gln?Val?Gly?Ile

180 185 190

Leu?Asp?Asp?Thr?Arg?Ser?Thr?Phe?Gly?Arg?Ser?Tyr?Ala?Gly?Ser?Pro

195 200 205

Asp?Glu?Leu?Ile?Asp?Gln?Leu?Gln?Gly?Arg?Gln?Ser?Cys?Asp?Gly?Ser

210 215 220

Arg?His?Leu?Asp?Ala?His?Arg?Pro?Gln?Pro?Asn?Gly?Cys

225 230 235

<210>181

<211>1614

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1591)

<223>RXN00689

<400>181

acagggaaat?cctcccagaa?ttaatcaccg?aagctgcaca?ccagatggct?actgcagacc 60

tcaatcgtgc?aaaggccctg?ttaagaacgg?atgcgatccg?atg?aat?gct?gca?acc 115

Met?Asn?Ala?Ala?Thr

1 5

agg?cgt?gct?tct?ctg?caa?ctc?ccc?tat?acc?cat?gtc?gat?gat?ttc?tac 163

Arg?Arg?Ala?Ser?Leu?Gln?Leu?Pro?Tyr?Thr?His?Val?Asp?Asp?Phe?Tyr

10 15 20

atc?aac?ggt?tcc?tgg?gtt?aaa?gca?gaa?gga?aca?caa?cgc?aac?ccc?gta 211

Ile?Asn?Gly?Ser?Trp?Val?Lys?Ala?Glu?Gly?Thr?Gln?Arg?Asn?Pro?Val

25 30 35

gtt?gat?cct?gcg?gtc?ggt?caa?gaa?tgg?gga?tct?gtt?cca?gaa?gca?acc 259

Val?Asp?Pro?Ala?Val?Gly?Gln?Glu?Trp?Gly?Ser?Val?Pro?Glu?Ala?Thr

40 45 50

gca?tct?gaa?ttg?gac?tct?gcg?gtg?gga?gct?gca?cgt?aca?gcg?cta?aag 307

Ala?Ser?Glu?Leu?Asp?Ser?Ala?Val?Gly?Ala?Ala?Arg?Thr?Ala?Leu?Lys

55 60 65

tcg?tgg?agt?gca?ctt?aca?ggt?gcg?gaa?cga?aca?ggc?tac?ctc?ctg?aaa 355

Ser?Trp?Ser?Ala?Leu?Thr?Gly?Ala?Glu?Arg?Thr?Gly?Tyr?Leu?Leu?Lys

70 75 80 85

atc?gcg?acg?gaa?att?gaa?tcc?cgt?tct?gaa?gct?cta?gca?ctt?act?aat 403

Ile?Ala?Thr?Glu?Ile?Glu?Ser?Arg?Ser?Glu?Ala?Leu?Ala?Leu?Thr?Asn

90 95 100

acc?cgc?gaa?aat?ggt?tcc?ccc?att?tcc?gag?acc?cgt?gga?gct?gcg?tcc 451

Thr?Arg?Glu?Asn?Gly?Ser?Pro?Ile?Ser?Glu?Thr?Arg?Gly?Ala?Ala?Ser

105 110 115

aat?gca?gca?gga?att?ttc?cgt?tac?ttt?gcc?act?ctc?gcg?cct?tgg?tta 499

Asn?Ala?Ala?Gly?Ile?Phe?Arg?Tyr?Phe?Ala?Thr?Leu?Ala?Pro?Trp?Leu

120 125 130

gac?ggc?gaa?gac?atc?cgc?cca?ttt?cct?gcc?ggt?agc?gcc?gaa?tcc?atc 547

Asp?Gly?Glu?Asp?Ile?Arg?Pro?Phe?Pro?Ala?Gly?Ser?Ala?Glu?Ser?Ile

135 140 145

gtg?gat?aaa?gat?ccc?atc?ggt?gtc?tgc?gca?ctc?atc?gcc?cca?tgg?aat 595

Val?Asp?Lys?Asp?Pro?Ile?Gly?Val?Cys?Ala?Leu?Ile?Ala?Pro?Trp?Asn

150 155 160 165

ttc?ccg?atc?aac?ctt?gta?gtc?atc?aaa?ctg?gca?cca?gca?ctt?ctt?gcc 643

Phe?Pro?Ile?Asn?Leu?Val?Val?Ile?Lys?Leu?Ala?Pro?Ala?Leu?Leu?Ala

170 175 180

ggc?tgt?acc?gtc?atc?atc?aaa?cca?gcc?tcc?ccc?acc?cca?ctg?tcg?atc 691

Gly?Cys?Thr?Val?Ile?Ile?Lys?Pro?Ala?Ser?Pro?Thr?Pro?Leu?Ser?Ile

185 190 195

cgt?ttc?atc?atc?gaa?gcc?atc?gaa?gcc?gcc?gga?gtg?cca?gca?ggc?gta 739

Arg?Phe?Ile?Ile?Glu?Ala?Ile?Glu?Ala?Ala?Gly?Val?Pro?Ala?Gly?Val

200 205 210

gtc?aac?cta?ctc?acc?ggt?tca?ggg?cgt?ttc?ggt?gat?gcc?ctt?gtc?cgc 787

Val?Asn?Leu?Leu?Thr?Gly?Ser?Gly?Arg?Phe?Gly?Asp?Ala?Leu?Val?Arg

215 220 225

cac?ccc?gga?gta?gac?aag?gta?gcg?ttt?acc?gga?tca?acg?cct?gtt?gga 835

His?Pro?Gly?Val?Asp?Lys?Val?Ala?Phe?Thr?Gly?Ser?Thr?Pro?Val?Gly

230 235 240 245

aag?aag?atc?gct?gcc?gcc?tgc?gga?gaa?cta?ctc?cga?cca?gtg?act?tta 883

Lys?Lys?Ile?Ala?Ala?Ala?Cys?Gly?Glu?Leu?Leu?Arg?Pro?Val?Thr?Leu

250 255 260

gag?cta?ggc?gga?aaa?tct?tcc?gcg?att?atc?ctt?cct?gat?gca?gac?atg 931

Glu?Leu?Gly?Gly?Lys?Ser?Ser?Ala?Ile?Ile?Leu?Pro?Asp?Ala?Asp?Met

265 270 275

tca?gta?ctc?tcg?acg?cgg?ttg?att?cga?tcc?tgt?atg?cgc?aac?act?gga 979

Ser?Val?Leu?Ser?Thr?Arg?Leu?Ile?Arg?Ser?Cys?Met?Arg?Asn?Thr?Gly

280 285 290

caa?acc?tgc?tac?atc?agt?acc?cgg?att?att?gcc?cct?agc?tca?cgc?tat 1027

Gln?Thr?Cys?Tyr?Ile?Ser?Thr?Arg?Ile?Ile?Ala?Pro?Ser?Ser?Arg?Tyr

295 300 305

gcg?gaa?gtc?gta?caa?aca?gtg?gca?agc?act?atc?gct?gca?ggt?aga?caa 1075

Ala?Glu?Val?Val?Gln?Thr?Val?Ala?Ser?Thr?Ile?Ala?Ala?Gly?Arg?Gln

310 315 320 325

ggt?gac?ccc?tat?gat?gaa?gaa?acg?gtt?ttt?ggg?cca?gtt?gcc?agc?gcc 1123

Gly?Asp?Pro?Tyr?Asp?Glu?Glu?Thr?Val?Phe?Gly?Pro?Val?Ala?Ser?Ala

330 335 340

tct?cag?tac?tca?acc?gtc?atg?tct?tac?att?gac?tcc?gca?cga?gag?gaa 1171

Ser?Gln?Tyr?Ser?Thr?Val?Met?Ser?Tyr?Ile?Asp?Ser?Ala?Arg?Glu?Glu

345 350 355

ggt?gca?cga?gtg?gtt?gca?ggt?gga?acc?cgg?tca?atc?agc?ctt?tct?gaa 1219

Gly?Ala?Arg?Val?Val?Ala?Gly?Gly?Thr?Arg?Ser?Ile?Ser?Leu?Ser?Glu

360 365 370

ggt?tta?gaa?tca?ggc?gag?ttt?atc?caa?cca?acc?gtg?ttt?gcc?gat?gtc 1267

Gly?Leu?Glu?Ser?Gly?Glu?Phe?Ile?Gln?Pro?Thr?Val?Phe?Ala?Asp?Val

375 380 385

acc?ccc?gac?atg?cgg?ata?tca?cgc?gaa?gaa?atc?ttc?ggc?cct?gtt?att 1315

Thr?Pro?Asp?Met?Arg?Ile?Ser?Arg?Glu?Glu?Ile?Phe?Gly?Pro?Val?Ile

390 395 400 405

tcc?atc?cta?aag?tac?gac?gat?aca?aac?ggt?gtt?tcc?gaa?gca?atc?gca 1363

Ser?Ile?Leu?Lys?Tyr?Asp?Asp?Thr?Asn?Gly?Val?Ser?Glu?Ala?Ile?Ala

410 415 420

cta?gcc?aac?aac?acg?aaa?ttc?ggt?ctc?ggt?ggc?ttg?gta?ttt?ggt?gcg 1411

Leu?Ala?Asn?Asn?Thr?Lys?Phe?Gly?Leu?Gly?Gly?Leu?Val?Phe?Gly?Ala

425 430 435

gat?gag?gaa?caa?gca?cta?gaa?gtc?gcc?cgt?caa?gtg?gat?tct?ggt?tcc 1459

Asp?Glu?Glu?Gln?Ala?Leu?Glu?Val?Ala?Arg?Gln?Val?Asp?Ser?Gly?Ser

440 445 450

gta?ggc?atc?aac?ttc?ttc?ggt?tcc?aac?cat?tcc?gcc?cca?ttt?gga?gga 1507

Val?Gly?Ile?Asn?Phe?Phe?Gly?Ser?Asn?His?Ser?Ala?Pro?Phe?Gly?Gly

455 460 465

cgc?cac?gaa?tcc?ggt?atg?gga?gtg?gaa?tac?ggc?atc?gaa?ggc?ctc?agt 1555

Arg?His?Glu?Ser?Gly?Met?Gly?Val?Glu?Tyr?Gly?Ile?Glu?Gly?Leu?Ser

470 475 480 485

gct?tac?ctg?aca?tac?aag?agt?att?cac?cga?acc?att?tagttactga 1601

Ala?Tyr?Leu?Thr?Tyr?Lys?Ser?Ile?His?Arg?Thr?Ile

490 495

aagttctcag?cta 1614

<210>182

<211>497

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>182

Met?Asn?Ala?Ala?Thr?Arg?Arg?Ala?Ser?Leu?Gln?Leu?Pro?Tyr?Thr?His

1 5 10 15

Val?Asp?Asp?Phe?Tyr?Ile?Asn?Gly?Ser?Trp?Val?Lys?Ala?Glu?Gly?Thr

20 25 30

Gln?Arg?Asn?Pro?Val?Val?Asp?Pro?Ala?Val?Gly?Gln?Glu?Trp?Gly?Ser

35 40 45

Val?Pro?Glu?Ala?Thr?Ala?Ser?Glu?Leu?Asp?Ser?Ala?Val?Gly?Ala?Ala

50 55 60

Arg?Thr?Ala?Leu?Lys?Ser?Trp?Ser?Ala?Leu?Thr?Gly?Ala?Glu?Arg?Thr

65 70 75 80

Gly?Tyr?Leu?Leu?Lys?Ile?Ala?Thr?Glu?Ile?Glu?Ser?Arg?Ser?Glu?Ala

85 90 95

Leu?Ala?Leu?Thr?Asn?Thr?Arg?Glu?Asn?Gly?Ser?Pro?Ile?Ser?Glu?Thr

100 105 110

Arg?Gly?Ala?Ala?Ser?Asn?Ala?Ala?Gly?Ile?Phe?Arg?Tyr?Phe?Ala?Thr

115 120 125

Leu?Ala?Pro?Trp?Leu?Asp?Gly?Glu?Asp?Ile?Arg?Pro?Phe?Pro?Ala?Gly

130 135 140

Ser?Ala?Glu?Ser?Ile?Val?Asp?Lys?Asp?Pro?Ile?Gly?Val?Cys?Ala?Leu

145 150 155 160

Ile?Ala?Pro?Trp?Asn?Phe?Pro?Ile?Asn?Leu?Val?Val?Ile?Lys?Leu?Ala

165 170 175

Pro?Ala?Leu?Leu?Ala?Gly?Cys?Thr?Val?Ile?Ile?Lys?Pro?Ala?Ser?Pro

180 185 190

Thr?Pro?Leu?Ser?Ile?Arg?Phe?Ile?Ile?Glu?Ala?Ile?Glu?Ala?Ala?Gly

195 200 205

Val?Pro?Ala?Gly?Val?Val?Asn?Leu?Leu?Thr?Gly?Ser?Gly?Arg?Phe?Gly

210 215 220

Asp?Ala?Leu?Val?Arg?His?Pro?Gly?Val?Asp?Lys?Val?Ala?Phe?Thr?Gly

225 230 235 240

Ser?Thr?Pro?Val?Gly?Lys?Lys?Ile?Ala?Ala?Ala?Cys?Gly?Glu?Leu?Leu

245 250 255

Arg?Pro?Val?Thr?Leu?Glu?Leu?Gly?Gly?Lys?Ser?Ser?Ala?Ile?Ile?Leu

260 265 270

Pro?Asp?Ala?Asp?Met?Ser?Val?Leu?Ser?Thr?Arg?Leu?Ile?Arg?Ser?Cys

275 280 285

Met?Arg?Asn?Thr?Gly?Gln?Thr?Cys?Tyr?Ile?Ser?Thr?Arg?Ile?Ile?Ala

290 295 300

Pro?Ser?Ser?Arg?Tyr?Ala?Glu?Val?Val?Gln?Thr?Val?Ala?Ser?Thr?Ile

305 310 315 320

Ala?Ala?Gly?Arg?Gln?Gly?Asp?Pro?Tyr?Asp?Glu?Glu?Thr?Val?Phe?Gly

325 330 335

Pro?Val?Ala?Ser?Ala?Ser?Gln?Tyr?Ser?Thr?Val?Met?Ser?Tyr?Ile?Asp

340 345 350

Ser?Ala?Arg?Glu?Glu?Gly?Ala?Arg?Val?Val?Ala?Gly?Gly?Thr?Arg?Ser

355 360 365

Ile?Ser?Leu?Ser?Glu?Gly?Leu?Glu?Ser?Gly?Glu?Phe?Ile?Gln?Pro?Thr

370 375 380

Val?Phe?Ala?Asp?Val?Thr?Pro?Asp?Met?Arg?Ile?Ser?Arg?Glu?Glu?Ile

385 390 395 400

Phe?Gly?Pro?Val?Ile?Ser?Ile?Leu?Lys?Tyr?Asp?Asp?Thr?Asn?Gly?Val

405 410 415

Ser?Glu?Ala?Ile?Ala?Leu?Ala?Asn?Asn?Thr?Lys?Phe?Gly?Leu?Gly?Gly

420 425 430

Leu?Val?Phe?Gly?Ala?Asp?Glu?Glu?Gln?Ala?Leu?Glu?Val?Ala?Arg?Gln

435 440 445

Val?Asp?Ser?Gly?Ser?Val?Gly?Ile?Asn?Phe?Phe?Gly?Ser?Asn?His?Ser

450 455 460

Ala?Pro?Phe?Gly?Gly?Arg?His?Glu?Ser?Gly?Met?Gly?Val?Glu?Tyr?Gly

465 470 475 480

Ile?Glu?Gly?Leu?Ser?Ala?Tyr?Leu?Thr?Tyr?Lys?Ser?Ile?His?Arg?Thr

485 490 495

Ile

<210>183

<211>750

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(727)

<223>FRXA00689

<400>183

actccgacca?gtgactttag?agctaggcgg?aaaatcttcc?gcgattatcc?ttcctgatgc 60

agacatgtca?gtactctcga?cgcggttgat?tcgatcctgt?atg?cgc?aac?act?gga 115

Met?Arg?Asn?Thr?Gly

1 5

caa?acc?tgc?tac?atc?agt?acc?cgg?att?att?gcc?cct?agc?tca?cgc?tat 163

Gln?Thr?Cys?Tyr?Ile?Ser?Thr?Arg?Ile?Ile?Ala?Pro?Ser?Ser?Arg?Tyr

10 15 20

gcg?gaa?gtc?gta?caa?aca?gtg?gca?agc?act?atc?gct?gca?ggt?aga?caa 211

Ala?Glu?Val?Val?Gln?Thr?Val?Ala?Ser?Thr?Ile?Ala?Ala?Gly?Arg?Gln

25 30 35

ggt?gac?ccc?tat?gat?gaa?gaa?acg?gtt?ttt?ggg?cca?gtt?gcc?agc?gcc 259

Gly?Asp?Pro?Tyr?Asp?Glu?Glu?Thr?Val?Phe?Gly?Pro?Val?Ala?Ser?Ala

40 45 50

tct?cag?tac?tca?acc?gtc?atg?tct?tac?att?gac?tcc?gca?cga?gag?gaa 307

Ser?Gln?Tyr?Ser?Thr?Val?Met?Ser?Tyr?Ile?Asp?Ser?Ala?Arg?Glu?Glu

55 60 65

ggt?gca?cga?gtg?gtt?gca?ggt?gga?acc?cgg?tca?atc?agc?ctt?tct?gaa 355

Gly?Ala?Arg?Val?Val?Ala?Gly?Gly?Thr?Arg?Ser?Ile?Ser?Leu?Ser?Glu

70 75 80 85

ggt?tta?gaa?tca?ggc?gag?ttt?atc?caa?cca?acc?gtg?ttt?gcc?gat?gtc 403

Gly?Leu?Glu?Ser?Gly?Glu?Phe?Ile?Gln?Pro?Thr?Val?Phe?Ala?Asp?Val

90 95 100

acc?ccc?gac?atg?cgg?ata?tca?cgc?gaa?gaa?atc?ttc?ggc?cct?gtt?att 451

Thr?Pro?Asp?Met?Arg?Ile?Ser?Arg?Glu?Glu?Ile?Phe?Gly?Pro?Val?Ile

105 ll0 115

tcc?atc?cta?aag?tac?gac?gat?aca?aac?ggt?gtt?tcc?gaa?gca?atc?gca 499

Ser?Ile?Leu?Lys?Tyr?Asp?Asp?Thr?Asn?Gly?Val?Ser?Glu?Ala?Ile?Ala

120 125 130

cta?gcc?aac?aac?acg?aaa?ttc?ggt?ctc?ggt?ggc?ttg?gta?ttt?ggt?gcg 547

Leu?Ala?Asn?Asn?Thr?Lys?Phe?Gly?Leu?Gly?Gly?Leu?Val?Phe?Gly?Ala

135 140 145

gat?gag?gaa?caa?gca?cta?gaa?gtc?gcc?cgt?caa?gtg?gat?tct?ggt?tcc 595

Asp?Glu?Glu?Gln?Ala?Leu?Glu?Val?Ala?Arg?Gln?Val?Asp?Ser?Gly?Ser

150 155 160 165

gta?ggc?atc?aac?ttc?ttc?ggt?tcc?aac?cat?tcc?gcc?cca?ttt?gga?gga 643

Val?Gly?Ile?Asn?Phe?Phe?Gly?Ser?Asn?His?Ser?Ala?Pro?Phe?Gly?Gly

170 175 180

cgc?cac?gaa?tcc?ggt?atg?gga?gtg?gaa?tac?ggc?atc?gaa?ggc?ctc?agt 691

Arg?His?Glu?Ser?Gly?Met?Gly?Val?Glu?Tyr?Gly?Ile?Glu?Gly?Leu?Ser

185 190 195

gct?tac?ctg?aca?tac?aag?agt?att?cac?cga?acc?att?tagttactga 737

Ala?Tyr?Leu?Thr?Tyr?Lys?Ser?Ile?His?Arg?Thr?Ile

200 205

aagttctcag?cta 750

<210>184

<211>209

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>184

Met?Arg?Asn?Thr?Gly?Gln?Thr?Cys?Tyr?Ile?Ser?Thr?Arg?Ile?Ile?Ala

1 5 10 15

Pro?Ser?Ser?Arg?Tyr?Ala?Glu?Val?Val?Gln?Thr?Val?Ala?Ser?Thr?Ile

20 25 30

Ala?Ala?Gly?Arg?Gln?Gly?Asp?Pro?Tyr?Asp?Glu?Glu?Thr?Val?Phe?Gly

35 40 45

Pro?Val?Ala?Ser?Ala?Ser?Gln?Tyr?Ser?Thr?Val?Met?Ser?Tyr?Ile?Asp

50 55 60

Ser?Ala?Arg?Glu?Glu?Gly?Ala?Arg?Val?Val?Ala?Gly?Gly?Thr?Arg?Ser

65 70 75 80

Ile?Ser?Leu?Ser?Glu?Gly?Leu?Glu?Ser?Gly?Glu?Phe?Ile?Gln?Pro?Thr

85 90 95

Val?Phe?Ala?Asp?Val?Thr?Pro?Asp?Met?Arg?Ile?Ser?Arg?Glu?Glu?Ile

100 105 110

Phe?Gly?Pro?Val?Ile?Ser?Ile?Leu?Lys?Tyr?Asp?Asp?Thr?Asn?Gly?Val

115 120 125

Ser?Glu?Ala?Ile?Ala?Leu?Ala?Asn?Asn?Thr?Lys?Phe?Gly?Leu?Gly?Gly

130 135 140

Leu?Val?Phe?Gly?Ala?Asp?Glu?Glu?Gln?Ala?Leu?Glu?Val?Ala?Arg?Gln

145 150 155 160

Val?Asp?Ser?Gly?Ser?Val?Gly?Ile?Asn?Phe?Phe?Gly?Ser?Asn?His?Ser

165 170 175

Ala?Pro?Phe?Gly?Gly?Arg?His?Glu?Ser?Gly?Met?Gly?Val?Glu?Tyr?Gly

180 185 190

Ile?Glu?Gly?Leu?Ser?Ala?Tyr?Leu?Thr?Tyr?Lys?Ser?Ile?His?Arg?Thr

195 200 205

Ile

<210>185

<211>878

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(855)

<223>RXN03128

<400>185

aac?gga?ctc?gcc?att?ccc?gac?att?gga?ttt?ggt?gta?ttc?caa?acc?cca 48

Asn?Gly?Leu?Ala?Ile?Pro?Asp?Ile?Gly?Phe?Gly?Val?Phe?Gln?Thr?Pro

1 5 10 15

ccc?gat?gaa?acc?cga?aac?tcc?gtt?aac?gct?gct?ctt?gaa?gcc?ggc?tat 96

Pro?Asp?Glu?Thr?Arg?Asn?Ser?Val?Asn?Ala?Ala?Leu?Glu?Ala?Gly?Tyr

20 25 30

cgc?cac?atc?gac?acc?gcc?gcc?gca?tac?ggc?aat?gaa?cgt?gaa?gtc?ggt 144

Arg?His?Ile?Asp?Thr?Ala?Ala?Ala?Tyr?Gly?Asn?Glu?Arg?Glu?Val?Gly

35 40 45

gaa?gca?atc?gca?gca?tcc?ggc?att?ggc?cgc?gac?gag?atc?acc?atc?gaa 192

Glu?Ala?Ile?Ala?Ala?Ser?Gly?Ile?Gly?Arg?Asp?Glu?Ile?Thr?Ile?Glu

50 55 60

acc?aaa?atc?tgg?gtg?acc?gac?tac?ggc?ttc?gag?gaa?act?ctc?cac?gca 240

Thr?Lys?Ile?Trp?Val?Thr?Asp?Tyr?Gly?Phe?Glu?Glu?Thr?Leu?His?Ala

65 70 75 80

ttc?gac?aag?gcc?aca?ggc?aag?ctt?ggt?gtc?gat?aca?ctg?gac?att?ttg 288

Phe?Asp?Lys?Ala?Thr?Gly?Lys?Leu?Gly?Val?Asp?Thr?Leu?Asp?Ile?Leu

85 90 95

atc?ttg?cac?cag?gca?gtg?cca?agc?agc?ttt?gat?cgc?acc?atc?gcc?gcc 336

Ile?Leu?His?Gln?Ala?Val?Pro?Ser?Ser?Phe?Asp?Arg?Thr?Ile?Ala?Ala

100 105 110

tac?aag?gcg?cta?gag?aag?ctg?ctt?ttc?gac?ggc?gcg?gtg?cgg?gca?atc 384

Tyr?Lys?Ala?Leu?Glu?Lys?Leu?Leu?Phe?Asp?Gly?Ala?Val?Arg?Ala?Ile

115 120 125

gga?gtc?agt?aat?ttc?atg?cca?gag?cac?ctg?gac?aaa?ctc?ctt?ttg?gaa 432

Gly?Val?Ser?Asn?Phe?Met?Pro?Glu?His?Leu?Asp?Lys?Leu?Leu?Leu?Glu

130 135 140

acc?tcc?att?gtc?cca?gct?ctg?aac?caa?atc?gaa?tgc?cac?ccc?tac?ttc 480

Thr?Ser?Ile?Val?Pro?Ala?Leu?Asn?Gln?Ile?Glu?Cys?H1is?Pro?Tyr?Phe

145 150 155 160

cag?cag?cgt?gac?gtg?ctt?gcc?cgc?aat?gag?cag?ctt?ggc?att?ttg?act 528

Gln?Gln?Arg?Asp?Val?Leu?Ala?Arg?Asn?Glu?Gln?Leu?Gly?Ile?Leu?Thr

165 170 175

cag?gcg?tgg?tca?cca?atc?ggt?ggc?atc?acc?ttc?tac?cgc?gac?gga?cag 576

Gln?Ala?Trp?Ser?Pro?Ile?Gly?Gly?Ile?Thr?Phe?Tyr?Arg?Asp?Gly?Gln

180 185 190

ctt?cca?agc?act?cta?gaa?aat?gag?gtc?atc?gct?gga?atc?gcc?gca?gaa 624

Leu?Pro?Ser?Thr?Leu?Glu?Asn?Glu?Val?Ile?Ala?Gly?Ile?Ala?Ala?Glu

195 200 205

gtt?ggc?aaa?aca?cca?gct?caa?gta?atg?ctg?cgc?tgg?cac?cta?cag?cgt 672

Val?Gly?Lys?Thr?Pro?Ala?Gln?Val?Met?Leu?Arg?Trp?His?Leu?Gln?Arg

210 215 220

aga?cgt?cac?gca?att?cca?aag?tct?gtg?acc?cca?tca?cgc?att?gtg?gaa 720

Arg?Arg?His?Ala?Ile?Pro?Lys?Ser?Val?Thr?Pro?Ser?Arg?Ile?Val?Glu

225 230 235 240

aac?ttt?gag?atc?ttt?gat?ttc?gaa?ctc?tcc?gat?gag?caa?cta?cag?caa 768

Asn?Phe?Glu?Ile?Phe?Asp?Phe?Glu?Leu?Ser?Asp?Glu?Gln?Leu?Gln?Gln

245 250 255

atc?gat?gcc?ctc?aac?acc?gat?ctg?cgc?ggt?ggc?cca?gaa?cca?gag?aac 816

Ile?Asp?Ala?Leu?Asn?Thr?Asp?Leu?Arg?Gly?Gly?Pro?Glu?Pro?Glu?Asn

260 265 270

atc?acc?atg?gaa?aac?tac?tac?cga?gaa?atc?cca?gaa?gcc?taaaggccct 865

Ile?Thr?Met?Glu?Asn?Tyr?Tyr?Arg?Glu?Ile?Pro?Glu?Ala

275 280 285

tagaggcgaa?tgt 878

<210>186

<211>285

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>186

Asn?Gly?Leu?Ala?Ile?Pro?Asp?Ile?Gly?Phe?Gly?Val?Phe?Gln?Thr?Pro

1 5 10 15

Pro?Asp?Glu?Thr?Arg?Asn?Ser?Val?Asn?Ala?Ala?Leu?Glu?Ala?Gly?Tyr

20 25 30

Arg?His?Ile?Asp?Thr?Ala?Ala?Ala?Tyr?Gly?Asn?Glu?Arg?Glu?Val?Gly

35 40 45

Glu?Ala?Ile?Ala?Ala?Ser?Gly?Ile?Gly?Arg?Asp?Glu?Ile?Thr?Ile?Glu

50 55 60

Thr?Lys?Ile?Trp?Val?Thr?Asp?Tyr?Gly?Phe?Glu?Glu?Thr?Leu?His?Ala

65 70 75 80

Phe?Asp?Lys?Ala?Thr?Gly?Lys?Leu?Gly?Val?Asp?Thr?Leu?Asp?Ile?Leu

85 90 95

Ile?Leu?His?Gln?Ala?Val?Pro?Ser?Ser?Phe?Asp?Arg?Thr?Ile?Ala?Ala

100 105 110

Tyr?Lys?Ala?Leu?Glu?Lys?Leu?Leu?Phe?Asp?Gly?Ala?Val?Arg?Ala?Ile

115 120 125

Gly?Val?Ser?Asn?Phe?Met?Pro?Glu?His?Leu?Asp?Lys?Leu?Leu?Leu?Glu

130 135 140

Thr?Ser?Ile?Val?Pro?Ala?Leu?Asn?Gln?Ile?Glu?Cys?His?Pro?Tyr?Phe

145 150 155 160

Gln?Gln?Arg?Asp?Val?Leu?Ala?Arg?Asn?Glu?Gln?Leu?Gly?Ile?Leu?Thr

165 170 175

Gln?Ala?Trp?Ser?Pro?Ile?Gly?Gly?Ile?Thr?Phe?Tyr?Arg?Asp?Gly?Gln

180 185 190

Leu?Pro?Ser?Thr?Leu?Glu?Asn?Glu?Val?Ile?Ala?Gly?Ile?Ala?Ala?Glu

195 200 205

Val?Gly?Lys?Thr?Pro?Ala?Gln?Val?Met?Leu?Arg?Trp?His?Leu?Gln?Arg

210 215 220

Arg?Arg?His?Ala?Ile?Pro?Lys?Ser?Val?Thr?Pro?Ser?Arg?Ile?Val?Glu

225 230 235 240

Asn?Phe?Glu?Ile?Phe?Asp?Phe?Glu?Leu?Ser?Asp?Glu?Gln?Leu?Gln?Gln

245 250 255

Ile?Asp?Ala?Leu?Asn?Thr?Asp?Leu?Arg?Gly?Gly?Pro?Glu?Pro?Glu?Asn

260 265 270

Ile?Thr?Met?Glu?Asn?Tyr?Tyr?Arg?Glu?Ile?Pro?Glu?Ala

275 280 285

<210>187

<211>522

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(5?22)

<223>FRXA02192

<400>187

att?ccc?gac?att?gga?ttt?ggt?gtc?ttc?caa?acc?cca?ccc?gat?gaa?acc 48

Ile?Pro?Asp?Ile?Gly?Phe?Gly?Val?Phe?Gln?Thr?Pro?Pro?Asp?Glu?Thr

1 5 10 15

cga?aac?tcc?gtt?aac?gct?gct?ctt?gaa?gcc?ggc?tat?cgc?cac?atc?gac 96

Arg?Asn?Ser?Val?Asn?Ala?Ala?Leu?Glu?Ala?Gly?Tyr?Arg?His?Ile?Asp

20 25 30

acc?gcg?gcc?gca?tac?ggc?aat?gaa?cgt?gaa?gtc?ggt?gaa?gca?atc?gca 144

Thr?Ala?Ala?Ala?Tyr?Gly?Asn?Glu?Arg?Glu?Val?Gly?Glu?Ala?Ile?Ala

35 40 45

gca?tcc?ggc?att?ggc?cgc?gac?gag?atc?acc?atc?gaa?acc?aaa?atc?tgg 192

Ala?Ser?Gly?Ile?Gly?Arg?Asp?Glu?Ile?Thr?Ile?Glu?Thr?Lys?Ile?Trp

50 55 60

gtg?acc?gac?tac?ggc?ttc?gag?gaa?act?ctc?cac?gca?ttc?gac?aag?gcc 240

Val?Thr?Asp?Tyr?Gly?Phe?Glu?Glu?Thr?Leu?His?Ala?Phe?Asp?Lys?Ala

65 70 75 80

aca?ggc?aag?ctt?ggt?gtc?gat?aca?ctg?gac?att?ttg?atc?ttg?cac?cag 288

Thr?Gly?Lys?Leu?Gly?Val?Asp?Thr?Leu?Asp?Ile?Leu?Ile?Leu?His?Gln

85 90 95

gca?gtg?cca?agc?agc?ttt?gat?cgc?acc?atc?gcc?gcc?tac?aag?gcg?cta 336

Ala?Val?Pro?Ser?Ser?Phe?Asp?Arg?Thr?Ile?Ala?Ala?Tyr?Lys?Ala?Leu

100 105 110

gag?aag?ctg?ctt?ttc?gac?ggc?gcg?gtg?cgg?gca?atc?gga?gtc?agt?aat 384

Glu?Lys?Leu?Leu?Phe?Asp?Gly?Ala?Val?Arg?Ala?Ile?Gly?Val?Ser?Asn

115 120 125

ttc?atg?cca?gag?cac?ctg?gac?aaa?ctc?ctt?ttg?gaa?acc?tcc?att?gtc 432

Phe?Met?Pro?Glu?His?Leu?Asp?Lys?Leu?Leu?Leu?Glu?Thr?Ser?Ile?Val

130 135 140

cca?gct?ctg?aac?caa?atc?gaa?tgc?cac?ccc?tac?ttc?cag?cag?cgt?gac 480

Pro?Ala?Leu?Asn?Gln?Ile?Glu?Cys?His?Pro?Tyr?Phe?Gln?Gln?Arg?Asp

145 150 155 160

gtg?ctt?gcc?cgc?aat?gag?cag?ctt?ggc?att?ttg?act?cag?gcg 522

Val?Leu?Ala?Arg?Asn?Glu?Gln?Leu?Gly?Ile?Leu?Thr?Gln?Ala

165 170

<210>188

<211>174

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>188

Ile?Pro?Asp?Ile?Gly?Phe?Gly?Val?Phe?Gln?Thr?Pro?Pro?Asp?Glu?Thr

1 5 10 15

Arg?Asn?Ser?Val?Asn?Ala?Ala?Leu?Glu?Ala?Gly?Tyr?Arg?His?Ile?Asp

20 25 30

Thr?Ala?Ala?Ala?Tyr?Gly?Asn?Glu?Arg?Glu?Val?Gly?Glu?Ala?Ile?Ala

35 40 45

Ala?Ser?Gly?Ile?Gly?Arg?Asp?Glu?Ile?Thr?Ile?Glu?Thr?Lys?Ile?Trp

50 55 60

Val?Thr?Asp?Tyr?Gly?Phe?Glu?Glu?Thr?Leu?His?Ala?Phe?Asp?Lys?Ala

65 70 75 80

Thr?Gly?Lys?Leu?Gly?Val?Asp?Thr?Leu?Asp?Ile?Leu?Ile?Leu?His?Gln

85 90 95

Ala?Val?Pro?Ser?Ser?Phe?Asp?Arg?Thr?Ile?Ala?Ala?Tyr?Lys?Ala?Leu

100 105 110

Glu?Lys?Leu?Leu?Phe?Asp?Gly?Ala?Val?Arg?Ala?Ile?Gly?Val?Ser?Asn

115 120 125

Phe?Met?Pro?Glu?His?Leu?Asp?Lys?Leu?Leu?Leu?Glu?Thr?Ser?Ile?Val

130 135 140

Pro?Ala?Leu?Asn?Gln?Ile?Glu?Cys?His?Pro?Tyr?Phe?Gln?Gln?Arg?Asp

145 150 155 160

Val?Leu?Ala?Arg?Asn?Glu?Gln?Leu?Gly?Ile?Leu?Thr?Gln?Ala

165 170

<210>189

<211>1039

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1039)

<223>RXA02351

<400>189

tgacacttta?cagactggtt?ttcaactaat?gacaccgaaa?gaaatacacc?tcaacctttt 60

tgctttcggt?gccgggcacc?acgcggcggc?gtggcgagcg?gtg?gag?gga?agc?gtc 115

Val?Glu?Gly?Ser?Val

1 5

gaa?aag?etg?ggt?tta?att?tcc?tgg?tgg?gag?gaa?ctc?gcg?cgc?acc?gct 163

Glu?Lys?Leu?Gly?Leu?Ile?Ser?Trp?Trp?Glu?Glu?Leu?Ala?Arg?Thr?Ala

10 15 20

gag?cgg?ggc?aag?ctg?gat?gcg?gtc?ttt?ttg?gcc?gat?ggg?cag?gcg?att 211

Glu?Arg?Gly?Lys?Leu?Asp?Ala?Val?Phe?Leu?Ala?Asp?Gly?Gln?Ala?Ile

25 30 35

aat?ccg?gtc?ggt?ctg?gag?aat?ggg?ccg?ggc?tgg?ttt?ttg?gag?ccg?gtg 259

Asn?Pro?Val?Gly?Leu?Glu?Asn?Gly?Pro?Gly?Trp?Phe?Leu?Glu?Pro?Val

40 45 50

acc?gcg?ttg?act?gcg?atg?gcg?cgg?gcg?acg?aac?aat?att?ggg?ttg?atc 307

Thr?Ala?Leu?Thr?Ala?Met?Ala?Arg?Ala?Thr?Asn?Asn?Ile?Gly?Leu?Ile

55 60 65

agc?aca?att?tcc?agt?acg?ttt?tgg?cag?ccg?ttt?cat?gcg?gcg?cgg?atg 355

Ser?Thr?Ile?Ser?Ser?Thr?Phe?Trp?Gln?Pro?Phe?His?Ala?Ala?Arg?Met

70 75 80 85

atc?gcc?agc?ttg?gat?cat?att?tcg?ggt?ggg?cgt?gct?gga?atc?aat?gtg 403

Ile?Ala?Ser?Leu?Asp?His?Ile?Ser?Gly?Gly?Arg?Ala?Gly?Ile?Asn?Val

90 95 100

gtg?aca?tcg?atg?acc?gat?gcg?gag?gcg?cgt?aac?cac?ggg?atg?gat?gcg 451

Val?Thr?Ser?Met?Thr?Asp?Ala?Glu?Ala?Arg?Asn?His?Gly?Met?Asp?Ala

105 110 115

ttg?ccg?ggt?cac?gat?gtt?cgc?tat?gcg?cgc?gct?gcg?gaa?ttt?att?gaa 499

Leu?Pro?Gly?His?Asp?Val?Arg?Tyr?Ala?Arg?Ala?Ala?Glu?Phe?Ile?Glu

120 125 130

acc?atc?act?gcg?ctg?tgg?gat?tct?tgg?cct?gcg?gaa?agt?ttg?gtg?atg 547

Thr?Ile?Thr?Ala?Leu?Trp?Asp?Ser?Trp?Pro?Ala?Glu?Ser?Leu?Val?Met

135 140 145

gat?cgt?gct?gga?aaa?ttt?gcg?gac?tcc?tcg?ctc?att?aaa?tct?atc?gat 595

Asp?Arg?Ala?Gly?Lys?Phe?Ala?Asp?Ser?Ser?Leu?Ile?Lys?Ser?Ile?Asp

150 155 160 165

cat?gat?ggt?gag?ttc?ttc?caa?gtc?gct?ggt?ccg?ctg?aat?atc?ccc?agt 643

His?Asp?Gly?Glu?Phe?Phe?Gln?Val?Ala?Gly?Pro?Leu?Asn?Ile?Pro?Ser

170 175 180

cct?ccg?cag?ggt?cga?ccc?gta?ctt?ttt?cag?gct?gga?tcc?tca?ccg?caa 691

Pro?Pro?Gln?Gly?Arg?Pro?Val?Leu?Phe?Gln?Ala?Gly?Ser?Ser?Pro?Gln

185 190 195

gga?cgg?gaa?atc?gct?gcg?aaa?tac?gcc?gag?gca?att?tac?tct?gtg?gcg 739

Gly?Arg?Glu?Ile?Ala?Ala?Lys?Tyr?Ala?Glu?Ala?Ile?Tyr?Ser?Val?Ala

200 205 210

tgg?gat?ttg?gag?caa?gcg?caa?gat?tat?cgc?tct?gat?att?cat?gct?cgt 787

Trp?Asp?Leu?Glu?Gln?Ala?Gln?Asp?Tyr?Arg?Ser?Asp?Ile?His?Ala?Arg

215 220 225

gcc?act?gcc?cag?ggt?cgc?gag?ccc?atg?ccg?gtg?ctt?cct?ggt?ttg?gtg 835

Ala?Thr?Ala?Gln?Gly?Arg?Glu?Pro?Met?Pro?Val?Leu?Pro?Gly?Leu?Val

230 235 240 245

act?ttt?gtt?ggc?acg?acc?gtg?gaa?gaa?gcg?cgt?gca?aaa?cag?cag?gct 883

Thr?Phe?Val?Gly?Thr?Thr?Val?Glu?Glu?Ala?Arg?Ala?Lys?Gln?Gln?Ala

250 255 260

ctt?aat?gcg?ttg?ctg?ccg?gtc?aaa?gac?tca?cta?aat?cag?ttg?agt?ttc 931

Leu?Asn?Ala?Leu?Leu?Pro?Val?Lys?Asp?Ser?Leu?Asn?Gln?Leu?Ser?Phe

265 270 275

ttt?gtg?ggt?caa?gat?tgc?tcg?acg?tgg?gat?ttg?gat?gca?cct?ccc?cca 979

Phe?Val?Gly?Gln?Asp?Cys?Ser?Thr?Trp?Asp?Leu?Asp?Ala?Pro?Pro?Pro

280 285 290

cca?ctg?cca?ccg?cta?gaa?gag?ttt?tcc?ggt?cct?aaa?ggc?agg?tac?gaa 1027

Pro?Leu?Pro?Pro?Leu?Glu?Glu?Phe?Ser?Gly?Pro?Lys?Gly?Arg?Tyr?Glu

295 300 305

acg?gtc?ctg?cgg 1039

Thr?Val?Leu?Arg

310

<210>190

<211>3l3

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>190

Val?Glu?Gly?Ser?Val?Glu?Lys?Leu?Gly?Leu?Ile?Ser?Trp?Trp?Glu?Glu

1 5 10 15

Leu?Ala?Arg?Thr?Ala?Glu?Arg?Gly?Lys?Leu?Asp?Ala?Val?Phe?Leu?Ala

20 25 30

Asp?Gly?Gln?Ala?Ile?Asn?Pro?Val?Gly?Leu?Glu?Asn?Gly?Pro?Gly?Trp

35 40 45

Phe?Leu?Glu?Pro?Val?Thr?Ala?Leu?Thr?Ala?Met?Ala?Arg?Ala?Thr?Asn

50 55 60

Asn?Ile?Gly?Leu?Ile?Ser?Thr?Ile?Ser?Ser?Thr?Phe?Trp?Gln?Pro?Phe

65 70 75 80

His?Ala?Ala?Arg?Met?Ile?Ala?Ser?Leu?Asp?His?Ile?Ser?Gly?Gly?Arg

85 90 95

Ala?Gly?Ile?Asn?Val?Val?Thr?Ser?Met?Thr?Asp?Ala?Glu?Ala?Arg?Asn

100 105 110

His?Gly?Met?Asp?Ala?Leu?Pro?Gly?His?Asp?Val?Arg?Tyr?Ala?Arg?Ala

115 120 125

Ala?Glu?Phe?Ile?Glu?Thr?Ile?Thr?Ala?Leu?Trp?Asp?Ser?Trp?Pro?Ala

130 135 140

Glu?Ser?Leu?Val?Met?Asp?Arg?Ala?Gly?Lys?Phe?Ala?Asp?Ser?Ser?Leu

145 150 155 160

Ile?Lys?Ser?Ile?Asp?His?Asp?Gly?Glu?Phe?Phe?Gln?Val?Ala?Gly?Pro

165 170 175

Leu?Asn?Ile?Pro?Ser?Pro?Pro?Gln?Gly?Arg?Pro?Val?Leu?Phe?Gln?Ala

180 185 190

Gly?Ser?Ser?Pro?Gln?Gly?Arg?Glu?Ile?Ala?Ala?Lys?Tyr?Ala?Glu?Ala

195 200 205

Ile?Tyr?Ser?Val?Ala?Trp?Asp?Leu?Glu?Gln?Ala?Gln?Asp?Tyr?Arg?Ser

210 215 220

Asp?Ile?His?Ala?Arg?Ala?Thr?Ala?Gln?Gly?Arg?Glu?Pro?Met?Pro?Val

225 230 235 240

Leu?Pro?Gly?Leu?Val?Thr?Phe?Val?Gly?Thr?Thr?Val?Glu?Glu?Ala?Arg

245 250 255

Ala?Lys?Gln?Gln?Ala?Leu?Asn?Ala?Leu?Leu?Pro?Val?Lys?Asp?Ser?Leu

260 265 270

Asn?Gln?Leu?Ser?Phe?Phe?Val?Gly?Gln?Asp?Cys?Ser?Thr?Trp?Asp?Leu

275 280 285

Asp?Ala?Pro?Pro?Pro?Pro?Leu?Pro?Pro?Leu?Glu?Glu?Phe?Ser?Gly?Pro

290 295 300

Lys?Gly?Arg?Tyr?Glu?Thr?Val?Leu?Arg

305 310

<210>191

<211>924

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(901)

<223>RXN00905

<400>191

cgctgcccct?ctatgctgct?cctagttacc?cctgcacaaa?tagcggtttt?tctcacgcat 60

tctgcatcga?gtcgggtcga?cgtatataag?gtggaaaggc?atg?acc?caa?ttc?gaa 115

Met?Thr?Gln?Phe?Glu

1 5

aac?gcg?caa?gta?ctt?aaa?gag?aac?atc?gaa?aac?caa?cgc?gag?cag?atc 163

Asn?Ala?Gln?Val?Leu?Lys?Glu?Asn?Ile?Glu?Asn?Gln?Arg?Glu?Gln?Ile

10 15 20

ttt?acc?cag?ttg?aaa?gaa?att?gtg?tct?ttc?aac?tcc?gtg?cac?agc?gat 211

Phe?Thr?Gln?Leu?Lys?Glu?Ile?Val?Ser?Phe?Asn?Ser?Val?His?Ser?Asp

25 30 35

cca?aac?cta?ctg?gag?gac?tac?gcc?ggc?gcg?aaa?gaa?tgg?gta?aaa?gaa 259

Pro?Asn?Leu?Leu?Glu?Asp?Tyr?Ala?Gly?Ala?Lys?Glu?Trp?Val?Lys?Glu

40 45 50

aca?ctg?acc?aac?gca?ggt?ctc?acc?gtc?agc?gaa?ttc?gct?gcc?gaa?gat 307

Thr?Leu?Thr?Asn?Ala?Gly?Leu?Thr?Val?Ser?Glu?Phe?Ala?Ala?Glu?Asp

55 60 65

gga?acc?acc?aac?ttc?atc?ggc?acc?cgc?aag?ggc?tcc?gaa?ggt?gca?cca 355

Gly?Thr?Thr?Asn?Phe?Ile?Gly?Thr?Arg?Lys?Gly?Ser?Glu?Gly?Ala?Pro

70 75 80 85

aag?gta?ctg?ctg?tac?agc?cac?ttc?gac?gtt?gtc?cca?tcc?ggc?cct?ttg 403

Lys?Val?Leu?Leu?Tyr?Ser?His?Phe?Asp?Val?Val?Pro?Ser?Gly?Pro?Leu

90 95 100

gat?ctc?tgg?gac?acc?aat?cct?ttt?gaa?ctc?acc?gag?cgc?gac?gct?ggc 451

Asp?Leu?Trp?Asp?Thr?Asn?Pro?Phe?Glu?Leu?Thr?Glu?Arg?Asp?Ala?Gly

105 110 115

cac?ggc?acc?cgc?tgg?tac?ggc?cgc?ggc?gcc?gct?gac?tgc?aag?ggc?aac 499

His?Gly?Thr?Arg?Trp?Tyr?Gly?Arg?Gly?Ala?Ala?Asp?Cys?Lys?Gly?Asn

120 125 130

ctg?gtc?atg?cac?ctc?gca?gca?ctg?cgc?gcc?gtc?gaa?gcc?agc?ggc?gac 547

Leu?Val?Met?His?Leu?Ala?Ala?Leu?Arg?Ala?Val?Glu?Ala?Ser?Gly?Asp

135 140 145

acc?aca?ctc?aac?ctc?acc?tac?gtg?gtc?gag?ggc?tcc?gag?gaa?atg?gga 595

Thr?Thr?Leu?Asn?Leu?Thr?Tyr?Val?Val?Glu?Gly?Ser?Glu?Glu?Met?Gly

150 155 160 165

ggc?gga?gcg?ctc?agc?gcg?ctc?atc?aag?gac?aag?cct?gag?ctt?ttc?gac 643

Gly?Gly?Ala?Leu?Ser?Ala?Leu?Ile?Lys?Asp?Lys?Pro?Glu?Leu?Phe?Asp

170 175 180

gca?gat?gtc?atc?ttg?att?gca?gac?agc?gga?aac?gct?tcc?gtg?ggc?acc 691

Ala?Asp?Val?Ile?Leu?Ile?Ala?Asp?Ser?Gly?Asn?Ala?Ser?Val?Gly?Thr

185 190 195

cca?acc?ttg?acc?act?acc?ctg?cgc?ggt?ggc?gga?cag?gtc?acc?gtc?acc 739

Pro?Thr?Leu?Thr?Thr?Thr?Leu?Arg?Gly?Gly?Gly?Gln?Val?Thr?Val?Thr

200 205 210

gtg?gac?acc?ctt?gaa?ggc?gct?gtt?cac?tcc?ggc?cag?aac?ggt?ggc?gct 787

Val?Asp?Thr?Leu?Glu?Gly?Ala?Val?His?Ser?Gly?Gln?Asn?Gly?Gly?Ala

215 220 225

gcc?cca?gat?gct?gtt?gct?gct?ctc?gtg?cgc?gtt?ctg?gat?act?ttg?cgc 835

Ala?Pro?Asp?Ala?Val?Ala?Ala?Leu?Val?Arg?Val?Leu?Asp?Thr?Leu?Arg

230 235 240 245

gat?gaa?cac?gga?cgc?acc?gtt?atc?gac?ggc?tgt?caa?cac?cac?cgc?aaa 883

Asp?Glu?His?Gly?Arg?Thr?Val?Ile?Asp?Gly?Cys?Gln?His?His?Arg?Lys

250 255 260

ctg?gaa?ggg?cga?gcc?tta?tgatccagag?actttccgca?gcg 924

Leu?Glu?Gly?Arg?Ala?Leu

265

<210>192

<211>267

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>192

Met?Thr?Gln?Phe?Glu?Asn?Ala?Gln?Val?Leu?Lys?Glu?Asn?Ile?Glu?Asn

1 5 10 15

Gln?Arg?Glu?Gln?Ile?Phe?Thr?Gln?Leu?Lys?Glu?Ile?Val?Ser?Phe?Asn

20 25 30

Ser?Val?His?Ser?Asp?Pro?Asn?Leu?Leu?Glu?Asp?Tyr?Ala?Gly?Ala?Lys

35 40 45

Glu?Trp?Val?Lys?Glu?Thr?Leu?Thr?Asn?Ala?Gly?Leu?Thr?Val?Ser?Glu

50 55 60

Phe?Ala?Ala?Glu?Asp?Gly?Thr?Thr?Asn?Phe?Ile?Gly?Thr?Arg?Lys?Gly

65 70 75 80

Ser?Glu?Gly?Ala?Pro?Lys?Val?Leu?Leu?Tyr?Ser?His?Phe?Asp?Val?Val

85 90 95

Pro?Ser?Gly?Pro?Leu?Asp?Leu?Trp?Asp?Thr?Asn?Pro?Phe?Glu?Leu?Thr

100 105 110

Glu?Arg?Asp?Ala?Gly?His?Gly?Thr?Arg?Trp?Tyr?Gly?Arg?Gly?Ala?Ala

115 120 125

Asp?Cys?Lys?Gly?Asn?Leu?Val?Met?His?Leu?Ala?Ala?Leu?Arg?Ala?Val

130 135 140

Glu?Ala?Ser?Gly?Asp?Thr?Thr?Leu?Asn?Leu?Thr?Tyr?Val?Val?Glu?Gly

145 150 155 160

Ser?Glu?Glu?Met?Gly?Gly?Gly?Ala?Leu?Ser?Ala?Leu?Ile?Lys?Asp?Lys

165 170 175

Pro?Glu?Leu?Phe?Asp?Ala?Asp?Val?Ile?Leu?Ile?Ala?Asp?Ser?Gly?Asn

180 l85 190

Ala?Ser?Val?Gly?Thr?Pro?Thr?Leu?Thr?Thr?Thr?Leu?Arg?Gly?Gly?Gly

195 200 205

Gln?Val?Thr?Val?Thr?Val?Asp?Thr?Leu?Glu?Gly?Ala?Val?His?Ser?Gly

210 215 220

Gln?Asn?Gly?Gly?Ala?Ala?Pro?Asp?Ala?Val?Ala?Ala?Leu?Val?Arg?Val

225 230 235 240

Leu?Asp?Thr?Leu?Arg?Asp?Glu?His?Gly?Arg?Thr?Val?Ile?Asp?Gly?Cys

245 250 255

Gln?His?His?Arg?Lys?Leu?Glu?Gly?Arg?Ala?Leu

260 265

<210>193

<211>716

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(693)

<223>FRXA00905

<400>193

gat?cca?aac?cta?ctg?gag?gac?tac?gcc?ggc?gcg?aaa?gaa?tgg?gta?aaa 48

Asp?Pro?Asn?Leu?Leu?Glu?Asp?Tyr?Ala?Gly?Ala?Lys?Glu?Trp?Val?Lys

1 5 10 15

gaa?aca?ctg?acc?aac?gca?ggt?ctc?acc?gtc?agc?gaa?ttc?gct?gcc?gaa 96

Glu?Thr?Leu?Thr?Asn?Ala?Gly?Leu?Thr?Val?Ser?Glu?Phe?Ala?Ala?Glu

20 25 30

gat?gga?acc?acc?aac?ttc?atc?ggc?acc?cgc?aag?ggc?tcc?gaa?ggt?gca 144

Asp?Gly?Thr?Thr?Asn?Phe?Ile?Gly?Thr?Arg?Lys?Gly?Ser?Glu?Gly?Ala

35 40 45

cca?aag?gta?ctg?ctg?tac?agc?cac?ttc?gac?gtt?gtc?cca?tcc?ggc?cct 192

Pro?Lys?Val?Leu?Leu?Tyr?Ser?His?Phe?Asp?Val?Val?Pro?Ser?Gly?Pro

50 55 60

ttg?gat?ctc?tgg?gac?acc?aat?cct?ttt?gaa?ctc?acc?gag?cgc?gac?gct 240

Leu?Asp?Leu?Trp?Asp?Thr?Asn?Pro?Phe?Glu?Leu?Thr?Glu?Arg?Asp?Ala

65 70 75 80

ggc?cac?ggc?acc?cgc?tgg?tac?ggc?cgc?ggc?gcc?gct?gac?tgc?aag?ggc 288

Gly?His?Gly?Thr?Arg?Trp?Tyr?Gly?Arg?Gly?Ala?Ala?Asp?Cys?Lys?Gly

85 90 95

aac?ctg?gtc?atg?cac?ctc?gca?gca?ctg?cgc?gcc?gtc?gaa?gcc?agc?ggc 336

Asn?Leu?Val?Met?His?Leu?Ala?Ala?Leu?Arg?Ala?Val?Glu?Ala?Ser?Gly

100 105 110

gac?acc?aca?ctc?aac?ctc?acc?tac?gtg?gtc?gag?ggc?tcc?gag?gaa?atg 384

Asp?Thr?Thr?Leu?Asn?Leu?Thr?Tyr?Val?Val?Glu?Gly?Ser?Glu?Glu?Met

115 120 125

gga?ggc?gga?gcg?ctc?agc?gcg?ctc?atc?aag?gac?aag?cct?gag?ctt?ttc 432

Gly?Gly?Gly?Ala?Leu?Ser?Ala?Leu?Ile?Lys?Asp?Lys?Pro?Glu?Leu?Phe

130 135 140

gac?gca?gat?gtc?atc?ttg?att?gca?gac?agc?gga?aac?gct?tcc?gtg?ggc 480

Asp?Ala?Asp?Val?Ile?Leu?Ile?Ala?Asp?Ser?Gly?Asn?Ala?Ser?Val?Gly

145 150 155 160

acc?cca?acc?ttg?acc?act?acc?ctg?cgc?ggt?ggc?gga?cag?gtc?acc?gtc 528

Thr?Pro?Thr?Leu?Thr?Thr?Thr?Leu?Arg?Gly?Gly?Gly?Gln?Val?Thr?Val

165 170 175

acc?gtg?gac?acc?ctt?gaa?ggc?gct?gtt?cac?tcc?ggc?cag?aac?ggt?ggc 576

Thr?Val?Asp?Thr?Leu?Glu?Gly?Ala?Val?His?Ser?Gly?Gln?Asn?Gly?Gly

180 185 190

gct?gcc?cca?gat?gct?gtt?gct?gct?ctc?gtg?cgc?gtt?ctg?gat?act?ttg 624

Ala?Ala?Pro?Asp?Ala?Val?Ala?Ala?Leu?Val?Arg?Val?Leu?Asp?Thr?Leu

195 200 205

cgc?gat?gaa?cac?gga?cgc?acc?gtt?atc?gac?ggc?tgt?caa?cac?cac?cgc 672

Arg?Asp?Glu?His?Gly?Arg?Thr?Val?Ile?Asp?Gly?Cys?Gln?His?His?Arg

210 215 220

aaa?ctg?gaa?ggg?cga?gcc?tta?tgatccagag?actttccgca?gcg 716

Lys?Leu?Glu?Gly?Arg?Ala?Leu

225 230

<210>194

<211>231

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>194

Asp?Pro?Asn?Leu?Leu?Glu?Asp?Tyr?Ala?Gly?Ala?Lys?Glu?Trp?Val?Lys

1 5 10 15

Glu?Thr?Leu?Thr?Asn?Ala?Gly?Leu?Thr?Val?Ser?Glu?Phe?Ala?Ala?Glu

20 25 30

Asp?Gly?Thr?Thr?Asn?Phe?Ile?Gly?Thr?Arg?Lys?Gly?Ser?Glu?Gly?Ala

35 40 45

Pro?Lys?Val?Leu?Leu?Tyr?Ser?His?Phe?Asp?Val?Val?Pro?Ser?Gly?Pro

50 55 60

Leu?Asp?Leu?Trp?Asp?Thr?Asn?Pro?Phe?Glu?Leu?Thr?Glu?Arg?Asp?Ala

65 70 75 80

Gly?His?Gly?Thr?Arg?Trp?Tyr?Gly?Arg?Gly?Ala?Ala?Asp?Cys?Lys?Gly

85 90 95

Asn?Leu?Val?Met?His?Leu?Ala?Ala?Leu?Arg?Ala?Val?Glu?Ala?Ser?Gly

100 105 110

Asp?Thr?Thr?Leu?Asn?Leu?Thr?Tyr?Val?Val?Glu?Gly?Ser?Glu?Glu?Met

115 120 125

Gly?Gly?Gly?Ala?Leu?Ser?Ala?Leu?Ile?Lys?Asp?Lys?Pro?Glu?Leu?Phe

130 135 140

Asp?Ala?Asp?Val?Ile?Leu?Ile?Ala?Asp?Ser?Gly?Asn?Ala?Ser?Val?Gly

145 150 155 160

Thr?Pro?Thr?Leu?Thr?Thr?Thr?Leu?Arg?Gly?Gly?Gly?Gln?Val?Thr?Val

165 170 175

Thr?Val?Asp?Thr?Leu?Glu?Gly?Ala?Val?His?Ser?Gly?Gln?Asn?Gly?Gly

180 185 190

Ala?Ala?Pro?Asp?Ala?Val?Ala?Ala?Leu?Val?Arg?Val?Leu?Asp?Thr?Leu

195 200 205

Arg?Asp?Glu?His?Gly?Arg?Thr?Val?Ile?Asp?Gly?Cys?Gln?His?His?Arg

210 215 220

Lys?Leu?Glu?Gly?Arg?Ala?Leu

225 230

<210>195

<211>627

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(604)

<223>RXA00906

<400>195

accgtggaca?cccttgaagg?cgctgttcac?tccggccaga?acggtggcgc?tgccccagat 60

gctgttgctg?ctctcgtgcg?cgttctggat?actttgcgcg?atg?aac?acg?gac?gca 115

Met?Asn?Thr?Asp?Ala

1 5

ccg?tta?tcg?acg?gct?gtc?aac?acc?acc?gca?aac?tgg?aag?ggc?gag?cct 163

Pro?Leu?Ser?Thr?Ala?Val?Asn?Thr?Thr?Ala?Asn?Trp?Lys?Gly?Glu?Pro

10 15 20

tat?gat?cca?gag?act?ttc?cgc?agc?gat?gcc?ggc?atc?ctc?gac?ggt?gta 211

Tyr?Asp?Pro?Glu?Thr?Phe?Arg?Ser?Asp?Ala?Gly?Ile?Leu?Asp?Gly?Val

25 30 35

gac?atc?atg?ggc?gac?ggc?gac?aac?cca?gca?agc?atg?etg?tgg?tcc?agg 259

Asp?Ile?Met?Gly?Asp?Gly?Asp?Asn?Pro?Ala?Ser?Met?Leu?Trp?Ser?Arg

40 45 50

cct?gca?atc?tcc?atc?acc?gga?ttc?act?tcc?acc?cca?gtg?gca?gaa?gca 307

Pro?Ala?Ile?Ser?Ile?Thr?Gly?Phe?Thr?Ser?Thr?Pro?Val?Ala?Glu?Ala

55 60 65

ctc?aac?gca?gtg?ccc?gca?acg?gcg?tcc?gcc?aag?cta?aac?ctt?cgc?gtg 355

Leu?Asn?Ala?Val?Pro?Ala?Thr?Ala?Ser?Ala?Lys?Leu?Asn?Leu?Arg?Val

70 75 80 85

cca?gca?ggc?ctg?gaa?gca?aac?gat?gtg?gcc?gag?aag?ctg?aag?cag?cac 403

Pro?Ala?Gly?Leu?Glu?Ala?Asn?Asp?Val?Ala?Glu?Lys?Leu?Lys?Gln?His

90 95 100

ctg?atc?aat?cac?aca?cct?tgg?ggc?gca?aag?atc?acg?gtg?gag?atc?gat 451

Leu?Ile?Asn?His?Thr?Pro?Trp?Gly?Ala?Lys?Ile?Thr?Val?Glu?Ile?Asp

105 110 115

gac?att?aac?caa?ccg?ttc?tcc?acc?gat?att?acc?ggc?cct?gca?atg?tcc 499

Asp?Ile?Asn?Gln?Pro?Phe?Ser?Thr?Asp?Ile?Thr?Gly?Pro?Ala?Met?Ser

120 125 130

acc?ctg?gcg?tcc?tgc?ctg?agc?gct?gcg?tac?gag?ggc?aag?gat?ctt?gtc 547

Thr?Leu?Ala?Ser?Cys?Leu?Ser?Ala?Ala?Tyr?Glu?Gly?Lys?Asp?Leu?Val

135 140 145

acc?gaa?ggc?agc?ggc?gga?tcc?att?cca?ctg?tgt?acc?gaa?ctg?att?gag 595

Thr?Glu?Gly?Ser?Gly?Gly?Ser?Ile?Pro?Leu?Cys?Thr?Glu?Leu?Ile?Glu

150 155 160 165

gtc?aac?cca?taagcagaat?tggcactcta?cgg 627

Val?Asn?Pro

<210>196

<211>168

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>196

Met?Asn?Thr?Asp?Ala?Pro?Leu?Ser?Thr?Ala?Val?Asn?Thr?Thr?Ala?Asn

1 5 10 15

Trp?Lys?Gly?Glu?Pro?Tyr?Asp?Pro?Glu?Thr?Phe?Arg?Ser?Asp?Ala?Gly

20 25 30

Ile?Leu?Asp?Gly?Val?Asp?Ile?Met?Gly?Asp?Gly?Asp?Asn?Pro?Ala?Ser

35 40 45

Met?Leu?Trp?Ser?Arg?Pro?Ala?Ile?Ser?Ile?Thr?Gly?Phe?Thr?Ser?Thr

50 55 60

Pro?Val?Ala?Glu?Ala?Leu?Asn?Ala?Val?Pro?Ala?Thr?Ala?Ser?Ala?Lys

65 70 75 80

Leu?Asn?Leu?Arg?Val?Pro?Ala?Gly?Leu?Glu?Ala?Asn?Asp?Val?Ala?Glu

85 90 95

Lys?Leu?Lys?Gln?His?Leu?Ile?Asn?His?Thr?Pro?Trp?Gly?Ala?Lys?Ile

100 105 110

Thr?Val?Glu?Ile?Asp?Asp?Ile?Asn?Gln?Pro?Phe?Ser?Thr?Asp?Ile?Thr

115 120 125

Gly?Pro?Ala?Met?Ser?Thr?Leu?Ala?Ser?Cys?Leu?Ser?Ala?Ala?Tyr?Glu

130 135 140

Gly?Lys?Asp?Leu?Val?Thr?Glu?Gly?Ser?Gly?Gly?Ser?Ile?Pro?Leu?Cys

145 150 155 160

Thr?Glu?Leu?Ile?Glu?Val?Asn?Pro

165

<210>197

<211>246

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(223)

<223>RXA00907

<400>197

cctgagcgct?gcgtacgagg?gcaaggatct?tgtcaccgaa?ggcagcggcg?gatccattcc 60

actgtgtacc?gaactgattg?aggtcaaccc?ataagcagaa?ttg?gca?ctc?tac?ggt 115

Leu?Ala?Leu?Tyr?Gly

1 5

gtg?gaa?gaa?ccc?ctc?acc?gtt?atc?cac?tcc?gct?aat?gaa?tct?gtt?gac 163

Val?Glu?Glu?Pro?Leu?Thr?Val?Ile?His?Ser?Ala?Asn?Glu?Ser?Val?Asp

10 15 20

ccc?aat?gag?att?cgc?gat?atc?gcc?acc?gca?gaa?gca?ttg?ttc?ctg?ctc 211

Pro?Asn?Glu?Ile?Arg?Asp?Ile?Ala?Thr?Ala?Glu?Ala?Leu?Phe?Leu?Leu

25 30 35

aac?tac?acc?aag?tagacccaaa?agcaggcgtt?aac 246

Asn?Tyr?Thr?Lys

40

<210>198

<211>41

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>198

Leu?Ala?Leu?Tyr?Gly?Val?Glu?Glu?Pro?Leu?Thr?Val?Ile?His?Ser?Ala

1 5 10 15

Asn?Glu?Ser?Val?Asp?Pro?Asn?Glu?Ile?Arg?Asp?Ile?Ala?Thr?Ala?Glu

20 25 30

Ala?Leu?Phe?Leu?Leu?Asn?Tyr?Thr?Lys

35 40

<210>199

<211>1386

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1363)

<223>RXA02101

<400>199

gccatggaat?gctccgttga?acgcaacagc?cttaaataca?atcccctcct?ataagccaag 60

agttttagtg?tcgctgcgca?ggtactctac?tatctaatcc?atg?agc?cgc?att?tca 115

Met?Ser?Arg?Ile?Ser

1 5

gaa?ctt?cta?aac?aat?cat?ggt?gtt?gat?ctg?tcg?tgg?caa?gag?gcc?gca 163

Glu?Leu?Leu?Asn?Asn?His?Gly?Val?Asp?Leu?Ser?Trp?Gln?Glu?Ala?Ala

10 15 20

tat?cag?gat?ttc?cac?gaa?cat?cct?gag?ctc?tcc?ggc?ttc?gaa?tca?gag 211

Tyr?Gln?Asp?Phe?His?Glu?His?Pro?Glu?Leu?Ser?Gly?Phe?Glu?Ser?Glu

25 30 35

acc?gca?gat?cgc?att?cag?aaa?tac?ctc?gag?cgt?ttt?gat?tgt?gag?gtg 259

Thr?Ala?Asp?Arg?Ile?Gln?Lys?Tyr?Leu?Glu?Arg?Phe?Asp?Cys?Glu?Val

40 45 50

att?cca?aat?gtt?ggc?ggt?tac?ggc?att?ctg?gcc?gtg?ttc?cga?aat?ggg 307

Ile?Pro?Asn?Val?Gly?Gly?Tyr?Gly?Ile?Leu?Ala?Val?Phe?Arg?Asn?Gly

55 60 65

tcg?aca?gat?cct?ggt?gcc?cct?gtt?gcg?tta?atg?cgc?gca?gat?ttc?gat 355

Ser?Thr?Asp?Pro?Gly?Ala?Pro?Val?Ala?Leu?Met?Arg?Ala?Asp?Phe?Asp

70 75 80 85

ggc?ctt?ccc?gtc?aag?gaa?atc?acc?gga?gtt?ccg?ttt?gct?tcc?act?cgt 403

Gly?Leu?Pro?Val?Lys?Glu?Ile?Thr?Gly?Val?Pro?Phe?Ala?Ser?Thr?Arg

90 95 100

atg?cgt?ccg?cat?gat?ggg?gca?aat?gtc?cat?gtc?atg?cac?gca?tgc?ggc 451

Met?Arg?Pro?His?Asp?Gly?Ala?Asn?Val?His?Val?Met?His?Ala?Cys?Gly

105 110 115

cac?gat?gtc?cac?gtc?acc?gcg?ctg?ctt?ggt?gcg?tgt?gcc?att?tta?gat 499

His?Asp?Val?His?Val?Thr?Ala?Leu?Leu?Gly?Ala?Cys?Ala?Ile?Leu?Asp

120 125 130

gag?cgt?cgc?gat?gca?tgg?gaa?ggc?acg?ttc?atc?gcg?ttg?ttc?cag?cca 547

Glu?Arg?Arg?Asp?Ala?Trp?Glu?Gly?Thr?Phe?Ile?Ala?Leu?Phe?Gln?Pro

135 140 145

tcg?gag?gaa?aac?tcc?caa?ggc?gct?aac?aag?atg?gtc?gcc?ggc?ggt?tta 595

Ser?Glu?Glu?Asn?Ser?Gln?Gly?Ala?Asn?Lys?Met?Val?Ala?Gly?Gly?Leu

150 155 160 165

gtt?gat?ctg?atc?cca?cgc?cct?gat?gtg?tgc?ttt?ggc?cag?cat?gta?gtc 643

Val?Asp?Leu?Ile?Pro?Arg?Pro?Asp?Val?Cys?Phe?Gly?Gln?His?Val?Val

170 175 180

ccc?ggt?gct?gca?gga?acc?gtg?atg?agc?atg?cct?ggc?ggt?gct?ctc?gct 691

Pro?Gly?Ala?Ala?Gly?Thr?Val?Met?Ser?Met?Pro?Gly?Gly?Ala?Leu?Ala

185 190 195

gcc?tgc?gat?tcc?att?gaa?atc?cgc?att?cag?ggt?cgc?agc?gcc?cat?ggt 739

Ala?Cys?Asp?Ser?Ile?Glu?Ile?Arg?Ile?Gln?Gly?Arg?Ser?Ala?His?Gly

200 205 210

tcc?atg?cct?cat?aat?tcc?atc?gat?ccc?act?tat?gtt?gca?gcg?atg?att 787

Ser?Met?Pro?His?Asn?Ser?Ile?Asp?Pro?Thr?Tyr?Val?Ala?Ala?Met?Ile

215 220 225

gtc?gtg?cga?ctc?caa?gga?atc?gtg?ggc?cgc?gag?gtt?tct?cca?gag?gat 835

Val?Val?Arg?Leu?Gln?Gly?Ile?Val?Gly?Arg?Glu?Val?Ser?Pro?Glu?Asp

230 235 240 245

ttc?gcc?gtt?att?tct?gtg?ggc?acc?ctc?cag?tcg?ggc?aac?acc?aac?aac 883

Phe?Ala?Val?Ile?Ser?Val?Gly?Thr?Leu?Gln?Ser?Gly?Asn?Thr?Asn?Asn

250 255 260

acc?att?cca?gca?agt?gct?cgt?ttg?gtg?ttg?aac?tgc?cgt?ttc?tac?aac 931

Thr?Ile?Pro?Ala?Ser?Ala?Arg?Leu?Val?Leu?Asn?Cys?Arg?Phe?Tyr?Asn

265 270 275

gac?aaa?gtc?aag?cac?aag?gtc?tac?cga?gcc?atc?gaa?cgt?gtt?gtc?cgt 979

Asp?Lys?Val?Lys?His?Lys?Val?Tyr?Arg?Ala?Ile?Glu?Arg?Val?Val?Arg

280 285 290

ggt?gaa?tgc?ctt?gct?tcc?ggt?att?gag?gaa?gaa?cct?gtc?att?gag?tac 1027

Gly?Glu?Cys?Leu?Ala?Ser?Gly?Ile?Glu?Glu?Glu?Pro?Val?Ile?Glu?Tyr

295 300 305

ttc?gcc?cac?ggt?gat?ctc?acc?aac?aac?acc?cct?gtt?gtc?ttc?gat?act 1075

Phe?Ala?His?Gly?Asp?Leu?Thr?Asn?Asn?Thr?Pro?Val?Val?Phe?Asp?Thr

310 315 320 325

gtg?cgc?cct?gtc?ttc?gac?gat?gtt?ttc?ggc?gag?gat?tct?att?gac?gct 1123

Val?Arg?Pro?Val?Phe?Asp?Asp?Val?Phe?Gly?Glu?Asp?Ser?Ile?Asp?Ala

330 335 340

tac?cgg?tgg?act?gcg?tcg?gag?gat?ttc?ccc?tcc?att?cct?aag?gca?ttc 1171

Tyr?Arg?Trp?Thr?Ala?Ser?Glu?Asp?Phe?Pro?Ser?Ile?Pro?Lys?Ala?Phe

345 350 355

aac?agc?cct?tac?ctg?tac?tgg?acg?att?ggt?gtc?acg?ccg?cgc?gat?cag 1219

Asn?Ser?Pro?Tyr?Leu?Tyr?Trp?Thr?Ile?Gly?Val?Thr?Pro?Arg?Asp?Gln

360 365 370

tgg?aca?gaa?gcc?gta?gaa?aga?gac?cgc?gtg?gca?tcg?gat?gtg?cca?gcc 1267

Trp?Thr?Glu?Ala?Val?Glu?Arg?Asp?Arg?Val?Ala?Ser?Asp?Val?Pro?Ala

375 380 385

aat?cac?atg?gga?gat?ttc?ctc?cct?gat?tat?gcg?ccg?acg?atg?tcc?gct 1315

Asn?His?Met?Gly?Asp?Phe?Leu?Pro?Asp?Tyr?Ala?Pro?Thr?Met?Ser?Ala

390 395 400 405

gcc?acc?cgc?gca?gcc?gca?gcc?gcg?ctg?ctg?acc?tac?ttg?gga?act?aac 1363

Ala?Thr?Arg?Ala?Ala?Ala?Ala?Ala?Leu?Leu?Thr?Tyr?Leu?Gly?Thr?Asn

410 415 420

taatcatcta?gttttctgcg?acg 1386

<210>200

<211>421

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>200

Met?Ser?Arg?Ile?Ser?Glu?Leu?Leu?Asn?Asn?His?Gly?Val?Asp?Leu?Ser

1 5 10 15

Trp?Gln?Glu?Ala?Ala?Tyr?Gln?Asp?Phe?His?Glu?His?Pro?Glu?Leu?Ser

20 25 30

Gly?Phe?Glu?Ser?Glu?Thr?Ala?Asp?Arg?Ile?Gln?Lys?Tyr?Leu?Glu?Arg

35 40 45

Phe?Asp?Cys?Glu?Val?Ile?Pro?Asn?Val?Gly?Gly?Tyr?Gly?Ile?Leu?Ala

50 55 60

Val?Phe?Arg?Asn?Gly?Ser?Thr?Asp?Pro?Gly?Ala?Pro?Val?Ala?Leu?Met

65 70 75 80

Arg?Ala?Asp?Phe?Asp?Gly?Leu?Pro?Val?Lys?Glu?Ile?Thr?Gly?Val?Pro

85 90 95

Phe?Ala?Ser?Thr?Arg?Met?Arg?Pro?His?Asp?Gly?Ala?Asn?Val?His?Val

100 105 110

Met?His?Ala?Cys?Gly?His?Asp?Val?His?Val?Thr?Ala?Leu?Leu?Gly?Ala

115 120 125

Cys?Ala?Ile?Leu?Asp?Glu?Arg?Arg?Asp?Ala?Trp?Glu?Gly?Thr?Phe?Ile

130 135 140

Ala?Leu?Phe?Gln?Pro?Ser?Glu?Glu?Asn?Ser?Gln?Gly?Ala?Asn?Lys?Met

145 150 155 160

Val?Ala?Gly?Gly?Leu?Val?Asp?Leu?Ile?Pro?Arg?Pro?Asp?Val?Cys?Phe

165 170 175

Gly?Gln?His?Val?Val?Pro?Gly?Ala?Ala?Gly?Thr?Val?Met?Ser?Met?Pro

180 185 190

Gly?Gly?Ala?Leu?Ala?Ala?Cys?Asp?Ser?Ile?Glu?Ile?Arg?Ile?Gln?Gly

195 200 205

Arg?Ser?Ala?His?Gly?Ser?Met?Pro?His?Asn?Ser?Ile?Asp?Pro?Thr?Tyr

210 215 220

Val?Ala?Ala?Met?Ile?Val?Val?Arg?Leu?Gln?Gly?Ile?Val?Gly?Arg?Glu

225 230 235 240

Val?Ser?Pro?Glu?Asp?Phe?Ala?Val?Ile?Ser?Val?Gly?Thr?Leu?Gln?Ser

245 250 255

Gly?Asn?Thr?Asn?Asn?Thr?Ile?Pro?Ala?Ser?Ala?Arg?Leu?Val?Leu?Asn

260 265 270

Cys?Arg?Phe?Tyr?Asn?Asp?Lys?Val?Lys?His?Lys?Val?Tyr?Arg?Ala?Ile

275 280 285

Glu?Arg?Val?Val?Arg?Gly?Glu?Cys?Leu?Ala?Ser?Gly?Ile?Glu?Glu?Glu

290 295 300

Pro?Val?Ile?Glu?Tyr?Phe?Ala?His?Gly?Asp?Leu?Thr?Asn?Asn?Thr?Pro

305 310 315 320

Val?Val?Phe?Asp?Thr?Val?Arg?Pro?Val?Phe?Asp?Asp?Val?Phe?Gly?Glu

325 330 335

Asp?Ser?Ile?Asp?Ala?Tyr?Arg?Trp?Thr?Ala?Ser?Glu?Asp?Phe?Pro?Ser

340 345 350

Ile?Pro?Lys?Ala?Phe?Asn?Ser?Pro?Tyr?Leu?Tyr?Trp?Thr?Ile?Gly?Val

355 360 365

Thr?Pro?Arg?Asp?Gln?Trp?Thr?Glu?Ala?Val?Glu?Arg?Asp?Arg?Val?Ala

370 375 380

Ser?Asp?Val?Pro?Ala?Asn?His?Met?Gly?Asp?Phe?Leu?Pro?Asp?Tyr?Ala

385 390 395 400

Pro?Thr?Met?Ser?Ala?Ala?Thr?Arg?Ala?Ala?Ala?Ala?Ala?Leu?Leu?Thr

405 410 415

Tyr?Leu?Gly?Thr?Asn

420

<210>201

<211>1389

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1366)

<223>RXN02565

<400>201

ggaaattcga?tacagtgcga?tgacgcgata?ttagaaagaa?aaagatgcgc?tttacgacga 60

aaccctcacc?ctccttcagg?aacttatccg?caacgcctgc?gtg?aat?gat?cta?acc 115

Val?Asn?Asp?Leu?Thr

1 5

cca?gat?tca?ggt?cag?gaa?att?aga?aac?gcg?gaa?agc?cta?gaa?cgt?ttc 163

Pro?Asp?Ser?Gly?Gln?Glu?Ile?Arg?Asn?Ala?Glu?Ser?Leu?Glu?Arg?Phe

10 15 20

ttt?gaa?gga?acc?ccc?aac?gtt?aaa?atc?acc?aag?ctg?gaa?ccg?cat?ccg 211

Phe?Glu?Gly?Thr?Pro?Asn?Val?Lys?Ile?Thr?Lys?Leu?Glu?Pro?His?Pro

25 30 35

ggc?cgg?acc?tca?att?atc?gtg?act?gtt?cca?ggc?agc?gat?cca?gat?gct 259

Gly?Arg?Thr?Ser?Ile?Ile?Val?Thr?Val?Pro?Gly?Ser?Asp?Pro?Asp?Ala

40 45 50

gag?cct?tta?aca?ctg?ctt?gga?cat?act?gat?gtt?gtg?cct?gtt?gat?ctg 307

Glu?Pro?Leu?Thr?Leu?Leu?Gly?His?Thr?Asp?Val?Val?Pro?Val?Asp?Leu

55 60 65

cct?aaa?tgg?act?aaa?gat?cca?ttc?ggt?gcg?gag?att?tcg?gat?gga?cag 355

Pro?Lys?Trp?Thr?Lys?Asp?Pro?Phe?Gly?Ala?Glu?Ile?Ser?Asp?Gly?Gln

70 75 80 85

att?tgg?ggt?aga?ggg?tcc?gtc?gat?atg?ctc?ttt?att?acc?gca?acc?caa 403

Ile?Trp?Gly?Arg?Gly?Ser?Val?Asp?Met?Leu?Phe?Ile?Thr?Ala?Thr?Gln

90 95 100

gcg?gcc?gtc?acc?cgt?caa?gta?gcc?cgt?gaa?ggc?ggc?ctg?cgt?ggc?acg 451

Ala?Ala?Val?Thr?Arg?Gln?Val?Ala?Arg?Glu?Gly?Gly?Leu?Arg?Gly?Thr

105 110 115

ctg?aca?ttc?gtt?ggc?gtt?gct?gat?gag?gaa?gcc?cgc?ggc?gga?ctc?gga 499

Leu?Thr?Phe?Val?Gly?Val?Ala?Asp?Glu?Glu?Ala?Arg?Gly?Gly?Leu?Gly

120 125 130

gcg?aag?tgg?ctt?tcc?gaa?gaa?cac?caa?aac?ctc?ttc?agc?tgg?aaa?aac 547

Ala?Lys?Trp?Leu?Ser?Glu?Glu?His?Gln?Asn?Leu?Phe?Ser?Trp?Lys?Asn

135 140 145

tgc?ctc?tcc?gaa?tcc?ggt?gga?tcg?cac?ctt?cca?gtc?cac?gac?ggc?agc 595

Cys?Leu?Ser?Glu?Ser?Gly?Gly?Ser?His?Leu?Pro?Val?His?Asp?Gly?Ser

150 155 160 165

gac?gca?gta?gta?att?aac?gtt?gga?gaa?aaa?ggt?gca?gct?caa?cgt?cgt 643

Asp?Ala?Val?Val?Ile?Asn?Val?Gly?Glu?Lys?Gly?Ala?Ala?Gln?Arg?Arg

170 175 180

att?cac?gtc?aat?ggc?gat?gct?ggt?cat?ggt?tcc?att?cct?ttc?gac?cgt 691

Ile?His?Val?Asn?Gly?Asp?Ala?Gly?His?Gly?Ser?Ile?Pro?Phe?Asp?Arg

185 190 195

gac?agc?gct?att?gtc?aag?atc?ggt?gaa?gtc?gcc?cgc?cga?atc?gct?gcc 739

Asp?Ser?Ala?Ile?Val?Lys?Ile?Gly?Glu?Val?Ala?Arg?Arg?Ile?Ala?Ala

200 205 210

gcc?gat?ctg?aag?gta?gcc?aag?gac?gat?atc?tgg?caa?ggc?ttc?gtc?caa 787

Ala?Asp?Leu?Lys?Val?Ala?Lys?Asp?Asp?Ile?Trp?Gln?Gly?Phe?Val?Gln

215 220 225

gcg?cac?cgt?ttc?gac?cca?gaa?acg?gag?cag?gcg?ctt?ctt?agc?ggg?acc 835

Ala?His?Arg?Phe?Asp?Pro?Glu?Thr?Glu?Gln?Ala?Leu?Leu?Ser?Gly?Thr

230 235 240 245

tcc?cct?gag?gcc?tac?gca?gag?ttc?ggc?gga?ctc?tcc?cgc?ttc?gcc?cac 883

Ser?Pro?Glu?Ala?Tyr?Ala?Glu?Phe?Gly?Gly?Leu?Ser?Arg?Phe?Ala?His

250 255 260

gcg?gtg?tct?cat?ctc?acg?atc?gcc?caa?act?gtg?gtt?cgt?gca?ggt?caa 931

Ala?Val?Ser?His?Leu?Thr?Ile?Ala?Gln?Thr?Val?Val?Arg?Ala?Gly?Gln

265 270 275

gcc?atc?aat?gta?ttg?cca?tcg?cat?gcg?tac?ttg?gaa?ctg?gat?atc?cgt 979

Ala?Ile?Asn?Val?Leu?Pro?Ser?His?Ala?Tyr?Leu?Glu?Leu?Asp?Ile?Arg

280 285 290

acc?ctt?cca?ggc?caa?acc?aat?gac?tat?gtt?gat?gac?acc?ctg?cgt?gct 1027

Thr?Leu?Pro?Gly?Gln?Thr?Asn?Asp?Tyr?Val?Asp?Asp?Thr?Leu?Arg?Ala

295 300 305

gct?ctg?ggc?gat?ctt?gcc?gat?gaa?gta?gaa?atc?gaa?cac?ctc?atc?tct 1075

Ala?Leu?Gly?Asp?Leu?Ala?Asp?Glu?Val?Glu?Ile?Glu?His?Leu?Ile?Ser

310 315 320 325

gaa?gaa?gca?acg?gtg?agc?cca?act?gat?tcc?agg?ttg?tat?aac?acc?ttg 1123

Glu?Glu?Ala?Thr?Val?Ser?Pro?Thr?Asp?Ser?Arg?Leu?Tyr?Asn?Thr?Leu

330 335 340

gaa?aaa?gtt?ctt?ggt?gat?ttc?ttc?ccc?gat?gcg?cct?gtg?gtc?cca?att 1171

Glu?Lys?Val?Leu?Gly?Asp?Phe?Phe?Pro?Asp?Ala?Pro?Val?Val?Pro?Ile

345 350 355

att?tcc?tct?ggt?ggc?tct?gac?ctg?cgc?ttt?ggt?cgt?cga?cta?ggc?ggt 1219

Ile?Ser?Ser?Gly?Gly?Ser?Asp?Leu?Arg?Phe?Gly?Arg?Arg?Leu?Gly?Gly

360 365 370

gtt?ggt?tat?ggt?ttt?gca?gtt?cat?gca?cgt?gaa?cga?act?ttg?gcg?gaa 1267

Val?Gly?Tyr?Gly?Phe?Ala?Val?His?Ala?Arg?Glu?Arg?Thr?Leu?Ala?Glu

375 380 385

gca?atg?ggg?caa?ctt?cac?tcc?cat?gac?gag?gcg?ctg?tac?ctg?gaa?gat 1315

Ala?Met?Gly?Gln?Leu?His?Ser?His?Asp?Glu?Ala?Leu?Tyr?Leu?Glu?Asp

390 395 400 405

ctt?gaa?ctg?act?gtt?cgg?ggt?tat?gac?tcc?gtc?gtg?cgt?gaa?ttc?cta 1363

Leu?Glu?Leu?Thr?Val?Arg?Gly?Tyr?Asp?Ser?Val?Val?Arg?Glu?Phe?Leu

410 415 420

ggc?taaaaacatg?aagcaggagt?ctt 1389

Gly

<210>202

<211>422

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>202

Val?Asn?Asp?Leu?Thr?Pro?Asp?Ser?Gly?Gln?Glu?Ile?Arg?Asn?Ala?Glu

1 5 10 15

Ser?Leu?Glu?Arg?Phe?Phe?Glu?Gly?Thr?Pro?Asn?Val?Lys?Ile?Thr?Lys

20 25 30

Leu?Glu?Pro?His?Pro?Gly?Arg?Thr?Ser?Ile?Ile?Val?Thr?Val?Pro?Gly

35 40 45

Ser?Asp?Pro?Asp?Ala?Glu?Pro?Leu?Thr?Leu?Leu?Gly?His?Thr?Asp?Val

50 55 60

Val?Pro?Val?Asp?Leu?Pro?Lys?Trp?Thr?Lys?Asp?Pro?Phe?Gly?Ala?Glu

65 70 75 80

Ile?Ser?Asp?Gly?Gln?Ile?Trp?Gly?Arg?Gly?Ser?Val?Asp?Met?Leu?Phe

85 90 95

Ile?Thr?Ala?Thr?Gln?Ala?Ala?Val?Thr?Arg?Gln?Val?Ala?Arg?Glu?Gly

100 105 110

Gly?Leu?Arg?Gly?Thr?Leu?Thr?Phe?Val?Gly?Val?Ala?Asp?Glu?Glu?Ala

115 120 125

Arg?Gly?Gly?Leu?Gly?Ala?Lys?Trp?Leu?Ser?Glu?Glu?His?Gln?Asn?Leu

130 135 140

Phe?Ser?Trp?Lys?Asn?Cys?Leu?Ser?Glu?Ser?Gly?Gly?Ser?His?Leu?Pro

145 150 155 160

Val?His?Asp?Gly?Ser?Asp?Ala?Val?Val?Ile?Asn?Val?Gly?Glu?Lys?Gly

165 170 175

Ala?Ala?Gln?Arg?Arg?Ile?His?Val?Asn?Gly?Asp?Ala?Gly?His?Gly?Ser

180 185 190

Ile?Pro?Phe?Asp?Arg?Asp?Ser?Ala?Ile?Val?Lys?Ile?Gly?Glu?Val?Ala

195 200 205

Arg?Arg?Ile?Ala?Ala?Ala?Asp?Leu?Lys?Val?Ala?Lys?Asp?Asp?Ile?Trp

210 215 220

Gln?Gly?Phe?Val?Gln?Ala?His?Arg?Phe?Asp?Pro?Glu?Thr?Glu?Gln?Ala

225 230 235 240

Leu?Leu?Ser?Gly?Thr?Ser?Pro?Glu?Ala?Tyr?Ala?Glu?Phe?Gly?Gly?Leu

245 250 255

Ser?Arg?Phe?Ala?His?Ala?Val?Ser?His?Leu?Thr?Ile?Ala?Gln?Thr?Val

260 265 270

Val?Arg?Ala?Gly?Gln?Ala?Ile?Asn?Val?Leu?Pro?Ser?His?Ala?Tyr?Leu

275 280 285

Glu?Leu?Asp?Ile?Arg?Thr?Leu?Pro?Gly?Gln?Thr?Asn?Asp?Tyr?Val?Asp

290 295 300

Asp?Thr?Leu?Arg?Ala?Ala?Leu?Gly?Asp?Leu?Ala?Asp?Glu?Val?Glu?Ile

305 310 315 320

Glu?His?Leu?Ile?Ser?Glu?Glu?Ala?Thr?Val?Ser?Pro?Thr?Asp?Ser?Arg

325 330 335

Leu?Tyr?Asn?Thr?Leu?Glu?Lys?Val?Leu?Gly?Asp?Phe?Phe?Pro?Asp?Ala

340 345 350

Pro?Val?Val?Pro?Ile?Ile?Ser?Ser?Gly?Gly?Ser?Asp?Leu?Arg?Phe?Gly

355 360 365

Arg?Arg?Leu?Gly?Gly?Val?Gly?Tyr?Gly?Phe?Ala?Val?His?Ala?Arg?Glu

370 375 380

Arg?Thr?Leu?Ala?Glu?Ala?Met?Gly?Gln?Leu?His?Ser?His?Asp?Glu?Ala

385 390 395 400

Leu?Tyr?Leu?Glu?Asp?Leu?Glu?Leu?Thr?Val?Arg?Gly?Tyr?Asp?Ser?Val

405 410 415

Val?Arg?Glu?Phe?Leu?Gly

420

<210>203

<211>365

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<22l>CDS

<222>(1)..(342)

<223>FRXA02565

<400>203

gct?gct?ctg?ggc?gat?ctt?gcc?gat?gaa?gta?gaa?atc?gaa?cac?ctc?atc 48

Ala?Ala?Leu?Gly?Asp?Leu?Ala?Asp?Glu?Val?Glu?Ile?Glu?His?Leu?Ile

1 5 10 15

tct?gaa?gaa?gca?acg?gtg?agc?cca?act?gat?tcc?agg?ttg?tat?aac?acc 96

Ser?Glu?Glu?Ala?Thr?Val?Ser?Pro?Thr?Asp?Ser?Arg?Leu?Tyr?Asn?Thr

20 25 30

ttg?gaa?aaa?gtt?ctt?ggt?gat?ttc?ttc?ccc?gat?gcg?cct?gtg?gtc?cca 144

Leu?Glu?Lys?Val?Leu?Gly?Asp?Phe?Phe?Pro?Asp?Ala?Pro?Val?Val?Pro

35 40 45

att?att?tcc?tct?ggt?ggc?tct?gac?ctg?cgc?ttt?ggt?cgt?cga?cta?ggc 192

Ile?Ile?Ser?Ser?Gly?Gly?Ser?Asp?Leu?Arg?Phe?Gly?Arg?Arg?Leu?Gly

50 55 60

ggt?gtt?ggt?tat?ggt?ttt?gca?gtt?cat?gca?cgt?gaa?cga?act?ttg?gcg 240

Gly?Val?Gly?Tyr?Gly?Phe?Ala?Val?His?Ala?Arg?Glu?Arg?Thr?Leu?Ala

65 70 75 80

gaa?gca?atg?ggg?caa?ctt?cac?tcc?cat?gac?gag?gcg?ctg?tac?ctg?gaa 288

Glu?Ala?Met?Gly?Gln?Leu?His?Ser?His?Asp?Glu?Ala?Leu?Tyr?Leu?Glu

85 90 95

gat?ctt?gaa?ctg?act?gtt?cgg?ggt?tat?gac?tcc?gtc?gtg?cgt?gaa?ttc 336

Asp?Leu?Glu?Leu?Thr?Val?Arg?Gly?Tyr?Asp?Ser?Val?Val?Arg?Glu?Phe

100 105 110

cta?ggc?taaaaacatg?aagcaggagt?ctt 365

Leu?Gly

<210>204

<211>114

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>?204

Ala?Ala?Leu?Gly?Asp?Leu?Ala?Asp?Glu?Val?Glu?Ile?Glu?His?Leu?Ile

1 5 10 15

Ser?Glu?Glu?Ala?Thr?Val?Ser?Pro?Thr?Asp?Ser?Arg?Leu?Tyr?Asn?Thr

20 25 30

Leu?Glu?Lys?Val?Leu?Gly?Asp?Phe?Phe?Pro?Asp?Ala?Pro?Val?Val?Pro

35 40 45

Ile?Ile?Ser?Ser?Gly?Gly?Ser?Asp?Leu?Arg?Phe?Gly?Arg?Arg?Leu?Gly

50 55 60

Gly?Val?Gly?Tyr?Gly?Phe?Ala?Val?His?Ala?Arg?Glu?Arg?Thr?Leu?Ala

65 70 75 80

Glu?Ala?Met?Gly?Gln?Leu?His?Ser?His?Asp?Glu?Ala?Leu?Tyr?Leu?Glu

85 90 95

Asp?Leu?Glu?Leu?Thr?Val?Arg?Gly?Tyr?Asp?Ser?Val?Val?Arg?Glu?Phe

100 105 110

Leu?Gly

<210>205

<211>738

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(738)

<223>FRXA02567

<400>205

ctt?atc?cgc?aac?gcc?tgc?gtg?aat?gat?cta?acc?cca?gat?tca?ggt?cag 48

Leu?Ile?Arg?Asn?Ala?Cys?Val?Asn?Asp?Leu?Thr?Pro?Asp?Ser?Gly?Gln

1 5 10 15

gaa?att?aga?aac?gcg?gaa?agc?cta?gaa?cgt?ttc?ttt?gaa?gga?acc?ccc 96

Glu?Ile?Arg?Asn?Ala?Glu?Ser?Leu?Glu?Arg?Phe?Phe?Glu?Gly?Thr?Pro

20 25 30

aac?gtt?aaa?atc?acc?aag?ctg?gaa?ccg?cat?ccg?ggc?cgg?acc?tca?att 144

Asn?Val?Lys?Ile?Thr?Lys?Leu?Glu?Pro?His?Pro?Gly?Arg?Thr?Ser?Ile

35 40 45

atc?gtg?act?gtt?cca?ggc?agc?gat?cca?gat?gct?gag?cct?tta?aca?ctg 192

Ile?Val?Thr?Val?Pro?Gly?Ser?Asp?Pro?Asp?Ala?Glu?Pro?Leu?Thr?Leu

50 55 60

ctt?gga?cat?act?gat?gtt?gtg?cct?gtt?gat?ctg?cct?aaa?tgg?act?aaa 240

Leu?Gly?His?Thr?Asp?Val?Val?Pro?Val?Asp?Leu?Pro?Lys?Trp?Thr?Lys

65 70 75 80

gat?cca?ttc?ggt?gcg?gag?att?tcg?gat?gga?cag?att?tgg?ggt?aga?ggg 288

Asp?Pro?Phe?Gly?Ala?Glu?Ile?Ser?Asp?Gly?Gln?Ile?Trp?Gly?Arg?Gly

85 90 95

tcc?gtc?gat?atg?ctc?ttt?att?acc?gca?acc?caa?gcg?gcc?gtc?acc?cgt 336

Ser?Val?Asp?Met?Leu?Phe?Ile?Thr?Ala?Thr?Gln?Ala?Ala?Val?Thr?Arg

100 105 110

caa?gta?gcc?cgt?gaa?ggc?ggc?ctg?cgt?ggc?acg?ctg?aca?ttc?gtt?ggc 384

Gln?Val?Ala?Arg?Glu?Gly?Gly?Leu?Arg?Gly?Thr?Leu?Thr?Phe?Val?Gly

115 120 125

gtt?gct?gat?gag?gaa?gcc?cgc?ggc?gga?ctc?gga?gcg?aag?tgg?ctt?tcc 432

Val?Ala?Asp?Glu?Glu?Ala?Arg?Gly?Gly?Leu?Gly?Ala?Lys?Trp?Leu?Ser

130 135 140

gaa?gaa?cac?caa?aac?ctc?ttc?agc?tgg?aaa?aac?tgc?ctc?tcc?gaa?tcc 480

Glu?Glu?His?Gln?Asn?Leu?Phe?Ser?Trp?Lys?Asn?Cys?Leu?Ser?Glu?Ser

145 150 155 160

ggt?gga?tcg?cac?ctt?cca?gtc?cac?gac?ggc?agc?gac?gca?gta?gta?att 528

Gly?Gly?Ser?His?Leu?Pro?Val?His?Asp?Gly?Ser?Asp?Ala?Val?Val?Ile

165 170 175

aac?gtt?gga?gaa?aaa?ggt?gca?gct?caa?cgt?cgt?att?cac?gtc?aat?ggc 576

Asn?Val?Gly?Glu?Lys?Gly?Ala?Ala?Gln?Arg?Arg?Ile?His?Val?Asn?Gly

180 185 190

gat?gct?ggt?cat?ggt?tcc?att?cct?ttc?gac?cgt?gac?agc?gct?att?gtc 624

Asp?Ala?Gly?His?Gly?Ser?Ile?Pro?Phe?Asp?Arg?Asp?Ser?Ala?Ile?Val

195 200 205

aag?atc?ggt?gaa?gtc?gcc?cgc?cga?atc?gct?gcc?gcc?gat?ctg?aag?gta 672

Lys?Ile?Gly?Glu?Val?Ala?Arg?Arg?Ile?Ala?Ala?Ala?Asp?Leu?Lys?Val

210 215 220

gcc?aag?gac?gat?atc?tgg?caa?ggc?ttc?gtc?caa?gcg?cac?cgt?ttc?gac 720

Ala?Lys?Asp?Asp?Ile?Trp?Gln?Gly?Phe?Val?Gln?Ala?His?Arg?Phe?Asp

225 230 235 240

cca?gaa?acg?gag?cag?gcg 738

Pro?Glu?Thr?Glu?Gln?Ala

245

<210>206

<211>246

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>206

Leu?Ile?Arg?Asn?Ala?Cys?Val?Asn?Asp?Leu?Thr?Pro?Asp?Ser?Gly?Gln

1 5 10 15

Glu?Ile?Arg?Asn?Ala?Glu?Ser?Leu?Glu?Arg?Phe?Phe?Glu?Gly?Thr?Pro

20 25 30

Asn?Val?Lys?Ile?Thr?Lys?Leu?Glu?Pro?His?Pro?Gly?Arg?Thr?Ser?Ile

35 40 45

Ile?Val?Thr?Val?Pro?Gly?Ser?Asp?Pro?Asp?Ala?Glu?Pro?Leu?Thr?Leu

50 55 60

Leu?Gly?His?Thr?Asp?Val?Val?Pro?Val?Asp?Leu?Pro?Lys?Trp?Thr?Lys

65 70 75 80

Asp?Pro?Phe?Gly?Ala?Glu?Ile?Ser?Asp?Gly?Gln?Ile?Trp?Gly?Arg?Gly

85 90 95

Ser?Val?Asp?Met?Leu?Phe?Ile?Thr?Ala?Thr?Gln?Ala?Ala?Val?Thr?Arg

100 105 110

Gln?Val?Ala?Arg?Glu?Gly?Gly?Leu?Arg?Gly?Thr?Leu?Thr?Phe?Val?Gly

115 120 125

Val?Ala?Asp?Glu?Glu?Ala?Arg?Gly?Gly?Leu?Gly?Ala?Lys?Trp?Leu?Ser

130 135 140

Glu?Glu?His?Gln?Asn?Leu?Phe?Ser?Trp?Lys?Asn?Cys?Leu?Ser?Glu?Ser

145 150 155 160

Gly?Gly?Ser?His?Leu?Pro?Val?His?Asp?Gly?Ser?Asp?Ala?Val?Val?Ile

165 170 175

Asn?Val?Gly?Glu?Lys?Gly?Ala?Ala?Gln?Arg?Arg?Ile?His?Val?Asn?Gly

180 185 190

Asp?Ala?Gly?His?Gly?Ser?Ile?Pro?Phe?Asp?Arg?Asp?Ser?Ala?Ile?Val

195 200 205

Lys?Ile?Gly?Glu?Val?Ala?Arg?Arg?Ile?Ala?Ala?Ala?Asp?Leu?Lys?Val

210 215 220

Ala?Lys?Asp?Asp?Ile?Trp?Gln?Gly?Phe?Val?Gln?Ala?His?Arg?Phe?Asp

225 230 235 240

Pro?Glu?Thr?Glu?Gln?Ala

245

<210>207

<211>1308

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1285)

<223>RXN03077

<400>207

accccgatcc?tttgttttcg?tgggatcact?attagactcg?actctaccgc?gctgcaggtt 60

ttcctgatac?gcctgcggac?aaaacagaaa?ggtatttcac?gtg?atg?gaa?att?ggt 115

Val?Met?Glu?Ile?Gly

1 5

gtg?cag?gtt?gcc?tca?tgg?atg?gac?cgc?cac?cat?gac?gag?gtc?ata?aag 163

Val?Gln?Val?Ala?Ser?Trp?Met?Asp?Arg?His?His?Asp?Glu?Val?Ile?Lys

10 15 20

tgg?cgc?agg?cat?ttg?cac?agc?cat?cct?gag?ctc?tcc?cac?atg?gaa?tac 211

Trp?Arg?Arg?His?Leu?His?Ser?His?Pro?Glu?Leu?Ser?His?Met?Glu?Tyr

25 30 35

cgc?acg?act?gag?tat?ttg?gcc?tcg?gtt?ctg?aaa?gat?cae?ggc?atg?gaa 259

Arg?Thr?Thr?Glu?Tyr?Leu?Ala?Ser?Val?Leu?Lys?Asp?His?Gly?Met?Glu

40 45 50

cca?cac?ctg?ttc?cca?gga?acc?ggt?ttg?atg?gtg?gat?atc?gga?cca?gaa 307

Pro?His?Leu?Phe?Pro?Gly?Thr?Gly?Leu?Met?Val?Asp?Ile?Gly?Pro?Glu

55 60 65

ggg?gac?tcc?cgc?ctg?gcg?ttt?cgc?gct?gat?atc?gat?gcc?ctt?ccg?ctg 355

Gly?Asp?Ser?Arg?Leu?Ala?Phe?Arg?Ala?Asp?Ile?Asp?Ala?Leu?Pro?Leu

70 75 80 85

ctt?gaa?tca?acc?ggc?tta?gag?ttc?tct?tcc?aca?gcc?act?ggc?gtt?gcg 403

Leu?Glu?Ser?Thr?Gly?Leu?Glu?Phe?Ser?Ser?Thr?Ala?Thr?Gly?Val?Ala

90 95 100

cat?gcc?tgc?gga?cat?gac?gtg?cac?acg?gtg?atc?gct?ttg?gca?ctt?gcc 451

His?Ala?Cys?Gly?His?Asp?Val?His?Thr?Val?Ile?Ala?Leu?Ala?Leu?Ala

105 110 115

tgt?gca?ctg?aac?acc?atc?gaa?ctg?ccc?arc?ggc?att?cgg?gtg?att?ttc 499

Cys?Ala?Leu?Asn?Thr?Ile?Glu?Leu?Pro?Ile?Gly?Ile?Arg?Val?Ile?Phe

120 125 130

cag?ccg?gca?gaa?gaa?gtc?atg?act?ggt?ggc?gca?acg?gac?gtc?att?gcc 547

Gln?Pro?Ala?Glu?Glu?Val?Met?Thr?Gly?Gly?Ala?Thr?Asp?Val?Ile?Ala

135 140 145

cac?ggt?ggc?ctt?gat?ggt?gtg?gat?gcg?att?tac?gcc?atc?cac?gtt?gaa 595

His?Gly?Gly?Leu?Asp?Gly?Val?Asp?Ala?Ile?Tyr?Ala?Ile?His?Val?Glu

150 155 160 165

ccc?aaa?ttg?aag?gtc?ggt?cgc?gtc?ggt?gta?cgc?gct?ggc?gcg?att?act 643

Pro?Lys?Leu?Lys?Val?Gly?Arg?Val?Gly?Val?Arg?Ala?Gly?Ala?Ile?Thr

170 175 180

tct?gcc?tca?gat?gtg?atc?gaa?atc?aga?gtc?aag?ggt?gaa?gga?gga?cat 691

Ser?Ala?Ser?Asp?Val?Ile?Glu?Ile?Arg?Val?Lys?Gly?Glu?Gly?Gly?His

185 190 195

agc?gca?cgt?cca?cac?ctc?tcc?gct?gat?gtt?gtt?tac?gcc?ttg?agc?aaa 739

Ser?Ala?Arg?Pro?His?Leu?Ser?Ala?Asp?Val?Val?Tyr?Ala?Leu?Ser?Lys

200 205 210

ttg?gtc?gtt?gat?ctt?ccc?ggt?ttg?ctg?tcc?agg?cgc?gtc?gat?cca?cgc 787

Leu?Val?Val?Asp?Leu?Pro?Gly?Leu?Leu?Ser?Arg?Arg?Val?Asp?Pro?Arg

215 220 225

acc?ggc?acc?gtg?ctt?gtt?ttc?ggc?acc?atc?aac?gcc?ggc?tat?gcg?ccc 835

Thr?Gly?Thr?Val?Leu?Val?Phe?Gly?Thr?Ile?Asn?Ala?Gly?Tyr?Ala?Pro

230 235 240 245

aac?gcg?atc?cca?gat?tcc?ggc?atc?gtg?tca?ggc?acc?ttg?cgt?aca?gcc 883

Asn?Ala?Ile?Pro?Asp?Ser?Gly?Ile?Val?Ser?Gly?Thr?Leu?Arg?Thr?Ala

250 255 260

gac?atc?tct?acc?tgg?cgt?gac?atg?cgt?ccg?ctt?atc?tct?gag?ctg?gtg 931

Asp?Ile?Ser?Thr?Trp?Arg?Asp?Met?Arg?Pro?Leu?Ile?Ser?Glu?Leu?Val

265 270 275

gaa?cag?gtg?ctc?gca?ccc?acc?gga?gtc?acc?cat?gaa?ctg?atc?tac?aat 979

Glu?Gln?Val?Leu?Ala?Pro?Thr?Gly?Val?Thr?His?Glu?Leu?Ile?Tyr?Asn

280 285 290

ccg?ggt?gtt?cca?cca?gtg?ctt?aac?gac?gat?gtc?gcc?acc?gct?ttg?ttg 1027

Pro?Gly?Val?Pro?Pro?Val?Leu?Asn?Asp?Asp?Val?Ala?Thr?Ala?Leu?Leu

295 300 305

gca?agc?gca?gca?cgc?gac?atg?gac?aca?caa?tct?gtt?gtc?caa?gcg?ccg 1075

Ala?Ser?Ala?Ala?Arg?Asp?Met?Asp?Thr?Gln?Ser?Val?Val?Gln?Ala?Pro

310 315 320 325

cag?tca?tcc?ggt?gga?gaa?gac?ttc?tcg?tgg?tac?ctt?gaa?cac?gtc?cca 1123

Gln?Ser?Ser?Gly?Gly?Glu?Asp?Phe?Ser?Trp?Tyr?Leu?Glu?His?Val?Pro

330 335 340

gga?tca?atg?gcc?cgg?ttg?ggt?tgc?tgg?ccg?ggg?cac?gga?ccc?aag?caa 1171

Gly?Ser?Met?Ala?Arg?Leu?Gly?Cys?Trp?Pro?Gly?His?Gly?Pro?Lys?Gln

345 350 355

gac?ctc?cat?caa?agt?gac?ctg?gtt?gtg?gat?gag?cga?gcc?atc?gga?gtt 1219

Asp?Leu?His?Gln?Ser?Asp?Leu?Val?Val?Asp?Glu?Arg?Ala?Ile?Gly?Val

360 365 370

ggc?gtc?agg?ctc?ttt?ggc?tcc?ctt?gtg?cag?cag?tac?agt?agc?cga?tct 1267

Gly?Val?Arg?Leu?Phe?Gly?Ser?Leu?Val?Gln?Gln?Tyr?Ser?Ser?Arg?Ser

375 380 385

gaa?gct?ttc?tta?aat?tcc?taatgggggt?agtgtgtagg?gct 1308

Glu?Ala?Phe?Leu?Asn?Ser

390 395

<210>208

<211>395

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>208

Val?Met?Glu?Ile?Gly?Val?Gln?Val?Ala?Ser?Trp?Met?Asp?Arg?His?His

1 5 10 15

Asp?Glu?Val?Ile?Lys?Trp?Arg?Arg?His?Leu?His?Ser?His?Pro?Glu?Leu

20 25 30

Ser?His?Met?Glu?Tyr?Arg?Thr?Thr?Glu?Tyr?Leu?Ala?Ser?Val?Leu?Lys

35 40 45

Asp?His?Gly?Met?Glu?Pro?His?Leu?Phe?Pro?Gly?Thr?Gly?Leu?Met?Val

50 55 60

Asp?Ile?Gly?Pro?Glu?Gly?Asp?Ser?Arg?Leu?Ala?Phe?Arg?Ala?Asp?Ile

65 70 75 80

Asp?Ala?Leu?Pro?Leu?Leu?Glu?Ser?Thr?Gly?Leu?Glu?Phe?Ser?Ser?Thr

85 90 95

Ala?Thr?Gly?Val?Ala?His?Ala?Cys?Gly?His?Asp?Val?His?Thr?Val?Ile

100 105 110

Ala?Leu?Ala?Leu?Ala?Cys?Ala?Leu?Asn?Thr?Ile?Glu?Leu?Pro?Ile?Gly

115 120 125

Ile?Arg?Val?Ile?Phe?Gln?Pro?Ala?Glu?Glu?Val?Met?Thr?Gly?Gly?Ala

130 135 140

Thr?Asp?Val?Ile?Ala?His?Gly?Gly?Leu?Asp?Gly?Val?Asp?Ala?Ile?Tyr

145 150 155 160

Ala?Ile?His?Val?Glu?Pro?Lys?Leu?Lys?Val?Gly?Arg?Val?Gly?Val?Arg

165 170 175

Ala?Gly?Ala?Ile?Thr?Ser?Ala?Ser?Asp?Val?Ile?Glu?Ile?Arg?Val?Lys

180 185 190

Gly?Glu?Gly?Gly?His?Ser?Ala?Arg?Pro?His?Leu?Ser?Ala?Asp?Val?Val

195 200 205

Tyr?Ala?Leu?Ser?Lys?Leu?Val?Val?Asp?Leu?Pro?Gly?Leu?Leu?Ser?Arg

210 215 220

Arg?Val?Asp?Pro?Arg?Thr?Gly?Thr?Val?Leu?Val?Phe?Gly?Thr?Ile?Asn

225 230 235 240

Ala?Gly?Tyr?Ala?Pro?Asn?Ala?Ile?Pro?Asp?Ser?Gly?Ile?Val?Ser?Gly

245 250 255

Thr?Leu?Arg?Thr?Ala?Asp?Ile?Ser?Thr?Trp?Arg?Asp?Met?Arg?Pro?Leu

260 265 270

Ile?Ser?Glu?Leu?Val?Glu?Gln?Val?Leu?Ala?Pro?Thr?Gly?Val?Thr?His

275 280 285

Glu?Leu?Ile?Tyr?Asn?Pro?Gly?Val?Pro?Pro?Val?Leu?Asn?Asp?Asp?Val

290 295 300

Ala?Thr?Ala?Leu?Leu?Ala?Ser?Ala?Ala?Arg?Asp?Met?Asp?Thr?Gln?Ser

305 310 315 320

Val?Val?Gln?Ala?Pro?Gln?Ser?Ser?Gly?Gly?Glu?Asp?Phe?Ser?Trp?Tyr

325 330 335

Leu?Glu?His?Val?Pro?Gly?Ser?Met?Ala?Arg?Leu?Gly?Cys?Trp?Pro?Gly

340 345 350

His?Gly?Pro?Lys?Gln?Asp?Leu?His?Gln?Ser?Asp?Leu?Val?Val?Asp?Glu

355 360 365

Arg?Ala?Ile?Gly?Val?Gly?Val?Arg?Leu?Phe?Gly?Ser?Leu?Val?Gln?Gln

370 375 380

Tyr?Ser?Ser?Arg?Ser?Glu?Ala?Phe?Leu?Asn?Ser

385 390 395

<210>209

<211>1308

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1285)

<223>FRXA02855

<400>209

accccgatcc?tttgttttcg?tgggatcact?attagactcg?actctaccgc?gctgcaggtt 60

ttcctgatac?gcctgcggac?aaaacagaaa?ggtatttcac?gtg?atg?gaa?att?ggt 115

Val?Met?Glu?Ile?Gly

1 5

gtg?cag?gtt?gcc?tca?tgg?atg?gac?cgc?cac?cat?gac?gag?gtc?ata?aag 163

Val?Gln?Val?Ala?Ser?Trp?Met?Asp?Arg?His?His?Asp?Glu?Val?Ile?Lys

10 15 20

tgg?cgc?agg?cat?ttg?cac?agc?cat?cct?gag?ctc?tcc?cac?atg?gaa?tac 211

Trp?Arg?Arg?His?Leu?His?Ser?His?Pro?Glu?Leu?Ser?His?Met?Glu?Tyr

25 30 35

cgc?acg?act?gag?tat?ttg?gcc?tcg?gtt?ctg?aaa?gat?cac?ggc?atg?gaa 259

Arg?Thr?Thr?Glu?Tyr?Leu?Ala?Ser?Val?Leu?Lys?Asp?His?Gly?Met?Glu

40 45 50

cca?cac?ctg?ttc?cca?gga?acc?ggt?ttg?atg?gtg?gat?atc?gga?cca?gaa 307

Pro?His?Leu?Phe?Pro?Gly?Thr?Gly?Leu?Met?Val?Asp?Ile?Gly?Pro?Glu

55 60 65

ggg?gac?tcc?cgc?ctg?gcg?ttt?cgc?gct?gat?atc?gat?gcc?ctt?ccg?ctg 355

Gly?Asp?Ser?Arg?Leu?Ala?Phe?Arg?Ala?Asp?Ile?Asp?Ala?Leu?Pro?Leu

70 75 80 85

ctt?gaa?tca?acc?ggc?tta?gag?ttc?tct?tcc?aca?gcc?act?ggc?gtt?gcg 403

Leu?Glu?Ser?Thr?Gly?Leu?Glu?Phe?Ser?Ser?Thr?Ala?Thr?Gly?Val?Ala

90 95 100

cat?gcc?tgc?gga?cat?gac?gtg?cac?acg?gtg?atc?gct?ttg?gca?ctt?gcc 451

His?Ala?Cys?Gly?His?Asp?Val?His?Thr?Val?Ile?Ala?Leu?Ala?Leu?Ala

105 110 115

tgt?gca?ctg?aac?acc?atc?gaa?ctg?ccc?atc?ggc?att?cgg?gtg?att?ttc 499

Cys?Ala?Leu?Asn?Thr?Ile?Glu?Leu?Pro?Ile?Gly?Ile?Arg?Val?Ile?Phe

120 125 130

cag?ccg?gca?gaa?gaa?gtc?atg?act?ggt?ggc?gca?acg?gac?gtc?att?gcc 547

Gln?Pro?Ala?Glu?Glu?Val?Met?Thr?Gly?Gly?Ala?Thr?Asp?Val?Ile?Ala

135 140 145

cac?ggt?ggc?ctt?gat?ggt?gtg?gat?gcg?att?tac?gcc?atc?cac?gtt?gaa 595

His?Gly?Gly?Leu?Asp?Gly?Val?Asp?Ala?Ile?Tyr?Ala?Ile?His?Val?Glu

150 155 160 165

ccc?aaa?ttg?aag?gtc?ggt?cgc?gtc?ggt?gta?cgc?gct?ggc?gcg?att?act 643

Pro?Lys?Leu?Lys?Val?Gly?Arg?Val?Gly?Val?Arg?Ala?Gly?Ala?Ile?Thr

170 175 180

tct?gcc?tca?gat?gtg?atc?gaa?atc?aga?gtc?aag?ggt?gaa?gga?gga?cat 691

Ser?Ala?Ser?Asp?Val?Ile?Glu?Ile?Arg?Val?Lys?Gly?Glu?Gly?Gly?His

185 190 195

agc?gca?cgt?cca?cac?ctc?tcc?gct?gat?gtt?gtt?tac?gcc?ttg?agc?aaa 739

Ser?Ala?Arg?Pro?His?Leu?Ser?Ala?Asp?Val?Val?Tyr?Ala?Leu?Ser?Lys

200 205 210

ttg?gtc?gtt?gat?ctt?ccc?ggt?ttg?ctg?tcc?agg?cgc?gtc?gat?cca?cgc 787

Leu?Val?Val?Asp?Leu?Pro?Gly?Leu?Leu?Ser?Arg?Arg?Val?Asp?Pro?Arg

215 220 225

acc?ggc?acc?gtg?ctt?gtt?ttc?ggc?acc?atc?aac?gcc?ggc?tat?gcg?ccc 835

Thr?Gly?Thr?Val?Leu?Val?Phe?Gly?Thr?Ile?Asn?Ala?Gly?Tyr?Ala?Pro

230 235 240 245

aac?gcg?atc?cca?gat?tcc?ggc?atc?gtg?tca?ggc?acc?ttg?cgt?aca?gcc 883

Asn?Ala?Ile?Pro?Asp?Ser?Gly?Ile?Val?Ser?Gly?Thr?Leu?Arg?Thr?Ala

250 255 260

gac?atc?tct?acc?tgg?cgt?gac?atg?cgt?ccg?ctt?atc?tct?gag?ctg?gtg 931

Asp?Ile?Ser?Thr?Trp?Arg?Asp?Met?Arg?Pro?Leu?Ile?Ser?Glu?Leu?Val

265 270 275

gaa?cag?gtg?ctc?gca?ccc?acc?gga?gtc?acc?cat?gaa?ctg?atc?tac?aat 979

Glu?Gln?Val?Leu?Ala?Pro?Thr?Gly?Val?Thr?His?Glu?Leu?Ile?Tyr?Asn

280 285 290

ccg?ggt?gtt?cca?cca?gtg?ctt?aac?gac?gat?gtc?gcc?acc?gct?ttg?ttg 1027

Pro?Gly?Val?Pro?Pro?Val?Leu?Asn?Asp?Asp?Val?Ala?Thr?Ala?Leu?Leu

295 300 305

gca?agc?gca?gca?cgc?gac?atg?gac?aca?caa?tct?gtt?gtc?caa?gcg?ccg 1075

Ala?Ser?Ala?Ala?Arg?Asp?Met?Asp?Thr?Gln?Ser?Val?Val?Gln?Ala?Pro

310 315 320 325

cag?tca?tcc?ggt?gga?gaa?gac?ttc?tcg?tgg?tac?ctt?gaa?cac?gtc?cca 1123

Gln?Ser?Ser?Gly?Gly?Glu?Asp?Phe?Ser?Trp?Tyr?Leu?Glu?His?Val?Pro

330 335 340

gga?tca?atg?gcc?cgg?ttg?ggt?tgc?tgg?ccg?ggg?cac?gga?ccc?aag?caa 1171

Gly?Ser?Met?Ala?Arg?Leu?Gly?Cys?Trp?Pro?Gly?His?Gly?Pro?Lys?Gln

345 350 355

gac?ctc?cat?caa?agt?gac?ctg?gtt?gtg?gat?gag?cga?gcc?atc?gga?gtt 1219

Asp?Leu?His?Gln?Ser?Asp?Leu?Val?Val?Asp?Glu?Arg?Ala?Ile?Gly?Val

360 365 370

ggc?gtc?agg?ctc?ttt?ggc?tcc?ctt?gtg?cag?cag?tac?agt?agc?cga?tct 1267

Gly?Val?Arg?Leu?Phe?Gly?Ser?Leu?Val?Gln?Gln?Tyr?Ser?Ser?Arg?Ser

375 380 385

gaa?gct?ttc?tta?aat?tcc?taatgggggt?agtgtgtagg?gct 1308

Glu?Ala?Phe?Leu?Asn?Ser

390 395

<210>210

<211>395

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>210

Val?Met?Glu?Ile?Gly?Val?Gln?Val?Ala?Ser?Trp?Met?Asp?Arg?His?His

1 5 10 15

Asp?Glu?Val?Ile?Lys?Trp?Arg?Arg?His?Leu?His?Ser?His?Pro?Glu?Leu

20 25 30

Ser?His?Met?Glu?Tyr?Arg?Thr?Thr?Glu?Tyr?Leu?Ala?Ser?Val?Leu?Lys

35 40 45

Asp?His?Gly?Met?Glu?Pro?His?Leu?Phe?Pro?Gly?Thr?Gly?Leu?Met?Val

50 55 60

Asp?Ile?Gly?Pro?Glu?Gly?Asp?Ser?Arg?Leu?Ala?Phe?Arg?Ala?Asp?Ile

65 70 75 80

Asp?Ala?Leu?Pro?Leu?Leu?Glu?Ser?Thr?Gly?Leu?Glu?Phe?Ser?Ser?Thr

85 90 95

Ala?Thr?Gly?Val?Ala?His?Ala?Cys?Gly?His?Asp?Val?His?Thr?Val?Ile

100 105 110

Ala?Leu?Ala?Leu?Ala?Cys?Ala?Leu?Asn?Thr?Ile?Glu?Leu?Pro?Ile?Gly

115 120 125

Ile?Arg?Val?Ile?Phe?Gln?Pro?Ala?Glu?Glu?Val?Met?Thr?Gly?Gly?Ala

130 135 140

Thr?Asp?Val?Ile?Ala?His?Gly?Gly?Leu?Asp?Gly?Val?Asp?Ala?Ile?Tyr

145 150 155 160

Ala?Ile?His?Val?Glu?Pro?Lys?Leu?Lys?Val?Gly?Arg?Val?Gly?Val?Arg

165 170 175

Ala?Gly?Ala?Ile?Thr?Ser?Ala?Ser?Asp?Val?Ile?Glu?Ile?Arg?Val?Lys

180 185 190

Gly?Glu?Gly?Gly?His?Ser?Ala?Arg?Pro?His?Leu?Ser?Ala?Asp?Val?Val

195 200 205

Tyr?Ala?Leu?Ser?Lys?Leu?Val?Val?Asp?Leu?Pro?Gly?Leu?Leu?Ser?Arg

210 215 220

Arg?Val?Asp?Pro?Arg?Thr?Gly?Thr?Val?Leu?Val?Phe?Gly?Thr?Ile?Asn

225 230 235 240

Ala?Gly?Tyr?Ala?Pro?Asn?Ala?Ile?Pro?Asp?Ser?Gly?Ile?Val?Ser?Gly

245 250 255

Thr?Leu?Arg?Thr?Ala?Asp?Ile?Ser?Thr?Trp?Arg?Asp?Met?Arg?Pro?Leu

260 265 270

Ile?Ser?Glu?Leu?Val?Glu?Gln?Val?Leu?Ala?Pro?Thr?Gly?Val?Thr?His

275 280 285

Glu?Leu?Ile?Tyr?Asn?Pro?Gly?Val?Pro?Pro?Val?Leu?Asn?Asp?Asp?Val

290 295 300

Ala?Thr?Ala?Leu?Leu?Ala?Ser?Ala?Ala?Arg?Asp?Met?Asp?Thr?Gln?Ser

305 310 315 320

Val?Val?Gln?Ala?Pro?Gln?Ser?Ser?Gly?Gly?Glu?Asp?Phe?Ser?Trp?Tyr

325 330 335

Leu?Glu?His?Val?Pro?Gly?Ser?Met?Ala?Arg?Leu?Gly?Cys?Trp?Pro?Gly

340 345 350

His?Gly?Pro?Lys?Gln?Asp?Leu?His?Gln?Ser?Asp?Leu?Val?Val?Asp?Glu

355 360 365

Arg?Ala?Ile?Gly?Val?Gly?Val?Arg?Leu?Phe?Gly?Ser?Leu?Val?Gln?Gln

370 375 380

Tyr?Ser?Ser?Arg?Ser?Glu?Ala?Phe?Leu?Asn?Ser

385 390 395

<210>211

<211>1509

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1486)

<223>RXA00026

<400>211

ccctttctgg?ctagcctggg?ctacattgtt?ggcaatttgg?ttctacgccg?atttgccgct 60

tggacctggc?tctgcgatct?tcctcgaagg?ataagttttc?atg?agt?act?gac?aat 115

Met?Ser?Thr?Asp?Asn

1 5

ttt?tct?cca?caa?gtt?ccg?tcg?act?gtg?tat?ttg?gat?tac?atg?gag?caa 163

Phe?Ser?Pro?Gln?Val?Pro?Ser?Thr?Val?Tyr?Leu?Asp?Tyr?Met?Glu?Gln

10 15 20

ggg?att?gcc?gcg?cgc?aaa?gcg?gag?gca?gaa?tct?aac?gcc?agc?acg?aag 211

Gly?Ile?Ala?Ala?Arg?Lys?Ala?Glu?Ala?Glu?Ser?Asn?Ala?Ser?Thr?Lys

25 30 35

ggg?gag?agc?ccg?gat?tat?cca?ggc?cag?cag?gtt?att?tgg?cgc?ctg?atc 259

Gly?Glu?Ser?Pro?Asp?Tyr?Pro?Gly?Gln?Gln?Val?Ile?Trp?Arg?Leu?Ile

40 45 50

cag?gaa?gca?ggg?gag?tcg?ttg?cgt?gat?gaa?ctg?cgc?aca?ctg?gct?ttc 307

Gln?Glu?Ala?Gly?Glu?Ser?Leu?Arg?Asp?Glu?Leu?Arg?Thr?Leu?Ala?Phe

55 60 65

acg?ctg?cac?gac?cat?ccg?gaa?gaa?gcg?ttc?gag?gag?gtg?ttc?gcc?acc 355

Thr?Leu?His?Asp?His?Pro?Glu?Glu?Ala?Phe?Glu?Glu?Val?Phe?Ala?Thr

70 75 80 85

gag?gaa?atc?aca?aaa?ctt?ctg?caa?aat?cat?ggt?ttt?gag?gtt?cag?agt 403

Glu?Glu?Ile?Thr?Lys?Leu?Leu?Gln?Asn?His?Gly?Phe?Glu?Val?Gln?Ser

90 95 100

gga?gtt?tat?ggt?gtt?aaa?acc?gct?cta?gaa?act?agt?ttt?gaa?acc?cct 451

Gly?Val?Tyr?Gly?Val?Lys?Thr?Ala?Leu?Glu?Thr?Ser?Phe?Glu?Thr?Pro

105 110 115

ggt?tat?gat?cca?gcg?cag?cac?cca?agc?att?gcg?atc?ttg?gcg?gaa?tac 499

Gly?Tyr?Asp?Pro?Ala?Gln?His?Pro?Ser?Ile?Ala?Ile?Leu?Ala?Glu?Tyr

120 125 130

gat?gcc?ctt?cca?gag?atc?ggc?cat?gca?tgc?ggg?cac?aat?atc?atc?gca 547

Asp?Ala?Leu?Pro?Glu?Ile?Gly?His?Ala?Cys?Gly?His?Asn?Ile?Ile?Ala

135 140 145

gca?gct?ggt?gtt?ggc?gca?ttt?tta?gct?gtc?acc?aac?atg?atc?aaa?act 595

Ala?Ala?Gly?Val?Gly?Ala?Phe?Leu?Ala?Val?Thr?Asn?Met?Ile?Lys?Thr

150 155 160 165

gcc?gaa?gtg?aaa?ggc?gtg?gat?cac?ctc?gac?ttt?gaa?ggc?cgg?atc?gtg 643

Ala?Glu?Val?Lys?Gly?Val?Asp?His?Leu?Asp?Phe?Glu?Gly?Arg?Ile?Val

170 175 180

ctg?ttg?gga?aca?cct?gct?gag?gag?ggg?cat?tcc?ggc?aag?gaa?tac?atg 691

Leu?Leu?Gly?Thr?Pro?Ala?Glu?Glu?Gly?His?Ser?Gly?Lys?Glu?Tyr?Met

185 190 195

atc?cga?aat?ggc?gca?ttc?gat?ggc?att?gat?gcg?tcg?att?atg?atg?cac 739

Ile?Arg?Asn?Gly?Ala?Phe?Asp?Gly?Ile?Asp?Ala?Ser?Ile?Met?Met?His

200 205 210

ccc?ttt?ggc?ttc?gat?ctg?gcg?gag?cat?gtt?tgg?gtg?ggc?aga?cgt?acc 787

Pro?Phe?Gly?Phe?Asp?Leu?Ala?Glu?His?Val?Trp?Val?Gly?Arg?Arg?Thr

215 220 225

atg?acg?gcg?acg?ttc?cac?ggt?gtc?tct?gca?cac?gcg?tct?tcg?cag?cct 835

Met?Thr?Ala?Thr?Phe?His?Gly?Val?Ser?Ala?His?Ala?Ser?Ser?Gln?Pro

230 235 240 245

ttc?atg?ggt?aaa?aat?gcc?ctc?gac?gct?gca?agt?ttg?gcg?tac?cag?ggc 883

Phe?Met?Gly?Lys?Asn?Ala?Leu?Asp?Ala?Ala?Ser?Leu?Ala?Tyr?Gln?Gly

250 255 260

ttc?gga?gtt?ttg?cgt?cag?caa?atg?cca?ccg?agc?gac?cgc?ctt?cac?gcc 931

Phe?Gly?Val?Leu?Arg?Gln?Gln?Met?Pro?Pro?Ser?Asp?Arg?Leu?His?Ala

265 270 275

att?att?acg?gaa?ggc?gga?aac?cgg?cca?agc?atc?att?cca?gac?act?gca 979

Ile?Ile?Thr?Glu?Gly?Gly?Asn?Arg?Pro?Ser?Ile?Ile?Pro?Asp?Thr?Ala

280 285 290

acg?atg?tcg?ctg?tac?gtg?cgt?tct?ttg?ttg?ccg?gaa?gca?ctc?aaa?gac 1027

Thr?Met?Ser?Leu?Tyr?Val?Arg?Ser?Leu?Leu?Pro?Glu?Ala?Leu?Lys?Asp

295 300 305

ata?tcg?aaa?cgc?gtg?gat?gat?gtg?ctc?gat?ggg?gcg?gcc?ttg?atg?gcg 1075

Ile?Ser?Lys?Arg?Val?Asp?Asp?Val?Leu?Asp?Gly?Ala?Ala?Leu?Met?Ala

310 315 320 325

ggg?gtt?ggc?gtc?gaa?aag?caa?tgg?gat?gtg?cac?cca?gct?agc?ttg?ccc 1123

Gly?Val?Gly?Val?Glu?Lys?Gln?Trp?Asp?Val?His?Pro?Ala?Ser?Leu?Pro

330 335 340

gtg?cgc?aac?aat?cat?gtg?ttg?gcg?cgg?cgt?tgg?gca?aaa?acg?cag?aat 1171

Val?Arg?Asn?Asn?His?Val?Leu?Ala?Arg?Arg?Trp?Ala?Lys?Thr?Gln?Asn

345 350 355

ctg?cgt?ggt?cga?acg?gcg?ctt?tcg?gag?ggt?att?ttg?ccc?gac?act?ctg 1219

Leu?Arg?Gly?Arg?Thr?Ala?Leu?Ser?Glu?Gly?Ile?Leu?Pro?Asp?Thr?Leu

360 365 370

gca?gca?tcg?act?gat?ttt?ggc?aat?gtc?tcg?cac?ctg?gtt?ccg?ggc?att 1267

Ala?Ala?Ser?Thr?Asp?Phe?Gly?Asn?Val?Ser?His?Leu?Val?Pro?Gly?Ile

375 380 385

cat?ccg?atg?gtg?aaa?att?tct?ccg?gaa?aac?gtt?gcg?ctc?cac?acc?aag 1315

His?Pro?Met?Val?Lys?Ile?Ser?Pro?Glu?Asn?Val?Ala?Leu?His?Thr?Lys

390 395 400 405

gaa?ttc?gcc?gct?tat?gcg?cgc?acg?gaa?gag?gcc?atc?gac?gca?gcc?gtc 1363

Glu?Phe?Ala?Ala?Tyr?Ala?Arg?Thr?Glu?Glu?Ala?Ile?Asp?Ala?Ala?Val

410 415 420

gac?gcc?gca?atc?ggg?ctg?gcg?caa?gtc?gcc?gtt?gac?gcg?ctt?gca?gat 1411

Asp?Ala?Ala?Ile?Gly?Leu?Ala?Gln?Val?Ala?Val?Asp?Ala?Leu?Ala?Asp

425 430 435

ccg?caa?atg?ctt?atc?gac?gcg?acc?ctc?gag?ttc?acc?aac?tcc?ggc?gac 1459

Pro?Gln?Met?Leu?Ile?Asp?Ala?Thr?Leu?Glu?Phe?Thr?Asn?Ser?Gly?Asp

440 445 450

gta?ctt?aaa?gta?ggg?gac?tat?ttg?gct?taggcaacga?ctccgaaacc 1506

Val?Leu?Lys?ValGly?Asp?Tyr?Leu?Ala

455 460

ttc

1509

<210>212

<211>462

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>212

Met?Ser?Thr?Asp?Asn?Phe?Ser?Pro?Gln?Val?Pro?Ser?Thr?Val?Tyr?Leu

1 5 10 15

Asp?Tyr?Met?Glu?Gln?Gly?Ile?Ala?Ala?Arg?Lys?Ala?Glu?Ala?Glu?Ser

20 25 30

Asn?Ala?Ser?Thr?Lys?Gly?Glu?Ser?Pro?Asp?Tyr?Pro?Gly?Gln?Gln?Val

35 40 45

Ile?Trp?Arg?Leu?Ile?Gln?Glu?Ala?Gly?Glu?Ser?Leu?Arg?Asp?Glu?Leu

50 55 60

Arg?Thr?Leu?Ala?Phe?Thr?Leu?His?Asp?His?Pro?Glu?Glu?Ala?Phe?Glu

65 70 75 80

Glu?Val?Phe?Ala?Thr?Glu?Glu?Ile?Thr?Lys?Leu?Leu?Gln?Asn?His?Gly

85 90 95

Phe?Glu?Val?Gln?Ser?Gly?Val?Tyr?Gly?Val?Lys?Thr?Ala?Leu?Glu?Thr

100 105 110

Ser?Phe?Glu?Thr?Pro?Gly?Tyr?Asp?Pro?Ala?Gln?His?Pro?Ser?Ile?Ala

115 120 125

Ile?Leu?Ala?Glu?Tyr?Asp?Ala?Leu?Pro?Glu?Ile?Gly?His?Ala?Cys?Gly

130 135 140

His?Asn?Ile?Ile?Ala?Ala?Ala?Gly?Val?Gly?Ala?Phe?Leu?Ala?Val?Thr

145 150 155 160

Asn?Met?Ile?Lys?Thr?Ala?Glu?Val?Lys?Gly?Val?Asp?His?Leu?Asp?Phe

165 170 175

Glu?Gly?Arg?Ile?Val?Leu?Leu?Gly?Thr?Pro?Ala?Glu?Glu?Gly?His?Ser

180 185 190

Gly?Lys?Glu?Tyr?Met?Ile?Arg?Asn?Gly?Ala?Phe?Asp?Gly?Ile?Asp?Ala

195 200 205

Ser?Ile?Met?Met?His?Pro?Phe?Gly?Phe?Asp?Leu?Ala?Glu?His?Val?Trp

210 215 220

Val?Gly?Arg?Arg?Thr?Met?Thr?Ala?Thr?Phe?His?Gly?Val?Ser?Ala?His

225 230 235 240

Ala?Ser?Ser?Gln?Pro?Phe?Met?Gly?Lys?Asn?Ala?Leu?Asp?Ala?Ala?Ser

245 250 255

Leu?Ala?Tyr?Gln?Gly?Phe?Gly?Val?Leu?Arg?Gln?Gln?Met?Pro?Pro?Ser

260 265 270

Asp?Arg?Leu?His?Ala?Ile?Ile?Thr?Glu?Gly?Gly?Asn?Arg?Pro?Ser?Ile

275 280 285

Ile?Pro?Asp?Thr?Ala?Thr?Met?Ser?Leu?Tyr?Val?Arg?Ser?Leu?Leu?Pro

290 295 300

Glu?Ala?Leu?Lys?Asp?Ile?Ser?Lys?Arg?Val?Asp?Asp?Val?Leu?Asp?Gly

305 310 315 320

Ala?Ala?Leu?Met?Ala?Gly?Val?Gly?Val?Glu?Lys?Gln?Trp?Asp?Val?His

325 330 335

Pro?Ala?Ser?Leu?Pro?Val?Arg?Asn?Asn?His?Val?Leu?Ala?Arg?Arg?Trp

340 345 350

Ala?Lys?Thr?Gln?Asn?Leu?Arg?Gly?Arg?Thr?Ala?Leu?Ser?Glu?Gly?Ile

355 360 365

Leu?Pro?Asp?Thr?Leu?Ala?Ala?Ser?Thr?Asp?Phe?Gly?Asn?Val?Ser?His

370 375 380

Leu?Val?Pro?Gly?Ile?His?Pro?Met?Val?Lys?Ile?Ser?Pro?Glu?Asn?Val

385 390 395 400

Ala?Leu?His?Thr?Lys?Glu?Phe?Ala?Ala?Tyr?Ala?Arg?Thr?Glu?Glu?Ala

405 410 415

Ile?Asp?Ala?Ala?Val?Asp?Ala?Ala?Ile?Gly?Leu?Ala?Gln?Val?Ala?Val

420 425 430

Asp?Ala?Leu?Ala?Asp?Pro?Gln?Met?Leu?Ile?Asp?Ala?Thr?Leu?Glu?Phe

435 440 445

Thr?Asn?Ser?Gly?Asp?Val?Leu?Lys?Val?Gly?Asp?Tyr?Leu?Ala

450 455 460

<210>213

<211>954

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(931)

<223>RXA01971

<400>213

aggtcttgtt?tatttcggct?actgattcag?tagctgcgct?ccgataggat?tcttagtttt 60

cagttcagta?tctttgagcc?acggctagaa?tgtgaatcct?atg?tct?aag?aag?aag 115

Met?Ser?Lys?Lys?Lys

1 5

cct?cgc?ccc?att?ccg?gtt?cct?gcc?caa?ttt?atc?cct?ggt?ctc?att?gat 163

Pro?Arg?Pro?Ile?Pro?Val?Pro?Ala?Gln?Phe?Ile?Pro?Gly?Leu?Ile?Asp

10 15 20

gcg?cat?aca?cat?ttg?gca?tcg?tgt?gga?gga?gat?ctt?gca?ggg?ttg?gtg 211

Ala?His?Thr?His?Leu?Ala?Ser?Cys?Gly?Gly?Asp?Leu?Ala?Gly?Leu?Val

25 30 35

gaa?agg?gcc?aag?gag?gcg?ggc?gtc?gaa?aag?ctt?tgt?acc?gtc?ggt?gat 259

Glu?Arg?Ala?Lys?Glu?Ala?Gly?Val?Glu?Lys?Leu?Cys?Thr?Val?Gly?Asp

40 45 50

ggt?ttg?gct?gag?gcc?gag?ctt?gcg?ctg?gag?gcc?gcg?caa?cag?ttt?ggc 307

Gly?Leu?Ala?Glu?Ala?Glu?Leu?Ala?Leu?Glu?Ala?Ala?Gln?Gln?Phe?Gly

55 60 65

aat?gtg?ttt?gct?gcg?tgt?gcg?att?cat?ccg?acg?aag?gct?gat?cag?ttg 355

Asn?Val?Phe?Ala?Ala?Cys?Ala?Ile?His?Pro?Thr?Lys?Ala?Asp?Gln?Leu

70 75 80 85

gat?ggg?gct?gcg?cgt?gcg?cgg?ctg?acg?cag?atg?gcg?gcg?gat?ccg?aat 403

Asp?Gly?Ala?Ala?Arg?Ala?Arg?Leu?Thr?Gln?Met?Ala?Ala?Asp?Pro?Asn

90 95 100

tgt?gtg?gcc?att?ggt?gag?act?ggt?ttg?gat?tcg?tat?tgg?atc?aag?cac 451

Cys?Val?Ala?Ile?Gly?Glu?Thr?Gly?Leu?Asp?Ser?Tyr?Trp?Ile?Lys?His

105 110 115

gat?cca?gag?gac?acg?gcg?gcg?ttg?gat?gtg?caa?gag?gag?gcg?ctg?cgc 499

Asp?Pro?Glu?Asp?Thr?Ala?Ala?Leu?Asp?Val?Gln?Glu?Glu?Ala?Leu?Arg

120 125 130

tgg?cat?att?gat?ttg?gca?att?agt?gcg?gat?aag?ccg?ttg?atg?att?cac 547

Trp?His?Ile?Asp?Leu?Ala?Ile?Ser?Ala?Asp?Lys?Pro?Leu?Met?Ile?His

135 140 145

aat?cgt?gag?gcg?gat?gct?gat?ttg?atg?cga?gtg?ttg?gcg?gat?gct?cca 595

Asn?Arg?Glu?Ala?Asp?Ala?Asp?Leu?Met?Arg?Val?Leu?Ala?Asp?Ala?Pro

150 155 160 165

cct?cca?aaa?gat?acg?att?ctg?cat?tgt?ttt?tct?tcg?ccg?ttg?gac?gtg 643

Pro?Pro?Lys?Asp?Thr?Ile?Leu?His?Cys?Phe?Ser?Ser?Pro?Leu?Asp?Val

170 175 180

gcg?aag?gaa?gcg?ttg?gat?cgt?gga?tat?gtg?ttg?agt?ttt?gcg?ggc?aat 691

Ala?Lys?Glu?Ala?Leu?Asp?Arg?Gly?Tyr?Val?Leu?Ser?Phe?Ala?Gly?Asn

185 190 195

gtg?acg?ttt?aag?cgt?aat?gag?gag?ttg?cgg?gag?gct?gct?cgt?att?gcg 739

Val?Thr?Phe?Lys?Arg?Asn?Glu?Glu?Leu?Arg?Glu?Ala?Ala?Arg?Ile?Ala

200 205 210

ccg?att?tcc?cag?att?ttg?att?gaa?acc?gat?gcg?ccg?tat?atg?acg?ccg 787

Pro?Ile?Ser?Gln?Ile?Leu?Ile?Glu?Thr?Asp?Ala?Pro?Tyr?Met?Thr?Pro

215 220 225

gag?ccg?ttt?cgg?ggg?agt?agg?aat?gag?ccg?tcg?ttg?att?ggt?cat?acg 835

Glu?Pro?Phe?Arg?Gly?Ser?Arg?Asn?Glu?Pro?Ser?Leu?Ile?Gly?His?Thr

230 235 240 245

gcg?cta?tgc?att?gcg?gag?gtt?cgg?ggg?atg?gct?gtg?gag?gat?gtt?gcg 883

Ala?Leu?Cys?Ile?Ala?Glu?Val?Arg?Gly?Met?Ala?Val?Glu?Asp?Val?Ala

250 255 260

gcg?gct?ttg?aat?gag?aat?ttt?gat?cgc?gtt?tat?ggg?gtc?aca?aat?cta 931

Ala?Ala?Leu?Asn?Glu?Asn?Phe?Asp?Arg?Val?Tyr?Gly?Val?Thr?Asn?Leu

265 270 275

taacgtgagg?tagctcacag?tca 954

<210>214

<211>277

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>214

Met?Ser?Lys?Lys?Lys?Pro?Arg?Pro?Ile?Pro?Val?Pro?Ala?Gln?Phe?Ile

1 5 10 15

Pro?Gly?Leu?Ile?Asp?Ala?His?Thr?His?Leu?Ala?Ser?Cys?Gly?Gly?Asp

20 25 30

Leu?Ala?Gly?Leu?Val?Glu?Arg?Ala?Lys?Glu?Ala?Gly?Val?Glu?Lys?Leu

35 40 45

Cys?Thr?Val?Gly?Asp?Gly?Leu?Ala?Glu?Ala?Glu?Leu?Ala?Leu?Glu?Ala

50 55 60

Ala?Gln?Gln?Phe?Gly?Asn?Val?Phe?Ala?Ala?Cys?Ala?Ile?His?Pro?Thr

65 70 75 80

Lys?Ala?Asp?Gln?Leu?Asp?Gly?Ala?Ala?Arg?Ala?Arg?Leu?Thr?Gln?Met

85 90 95

Ala?Ala?Asp?Pro?Asn?Cys?Val?Ala?Ile?Gly?Glu?Thr?Gly?Leu?Asp?Ser

100 105 110

Tyr?Trp?Ile?Lys?His?Asp?Pro?Glu?Asp?Thr?Ala?Ala?Leu?Asp?Val?Gln

115 120 125

Glu?Glu?Ala?Leu?Arg?Trp?His?Ile?Asp?Leu?Ala?Ile?Ser?Ala?Asp?Lys

130 135 140

Pro?Leu?Met?Ile?His?Asn?Arg?Glu?Ala?Asp?Ala?Asp?Leu?Met?Arg?Val

145 150 155 160

Leu?Ala?Asp?Ala?Pro?Pro?Pro?Lys?Asp?Thr?Ile?Leu?His?Cys?Phe?Ser

165 170 175

Ser?Pro?Leu?Asp?Val?Ala?Lys?Glu?Ala?Leu?Asp?Arg?Gly?Tyr?Val?Leu

180 185 190

Ser?Phe?Ala?Gly?Asn?Val?Thr?Phe?Lys?Arg?Asn?Glu?Glu?Leu?Arg?Glu

195 200 205

Ala?Ala?Arg?Ile?Ala?Pro?Ile?Ser?Gln?Ile?Leu?Ile?Glu?Thr?Asp?Ala

210 215 220

Pro?Tyr?Met?Thr?Pro?Glu?Pro?Phe?Arg?Gly?Ser?Arg?Asn?Glu?Pro?Ser

225 230 235 240

Leu?Ile?Gly?His?Thr?Ala?Leu?Cys?Ile?Ala?Glu?Val?Arg?Gly?Met?Ala

245 250 255

Val?Glu?Asp?Val?Ala?Ala?Ala?Leu?Asn?Glu?Asn?Phe?Asp?Arg?Val?Tyr

260 265 270

Gly?Val?Thr?Asn?Leu

275

<210>215

<211>954

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(931)

<223>RXA01802

<400>215

ggaattctgg?acaaaagtgt?tcactacgtt?agacatgaga?accagtgtgg?cacatcacag 60

gaaatcttcg?cgggtgttta?gacaacccgg?atgtgacaga?atg?ggc?gat?caa?gac 115

Met?Gly?Asp?Gln?Asp

1 5

ata?atc?gga?aag?gaa?tcc?aaa?caa?atg?gac?ttt?cgc?ctc?gtc?gcg?aca 163

Ile?Ile?Gly?Lys?Glu?Ser?Lys?Gln?Met?Asp?Phe?Arg?Leu?Val?Ala?Thr

10 15 20

gac?atg?gac?ggc?aca?ctt?tta?aac?acc?cac?cac?gaa?gtc?cca?gag?aaa 211

Asp?Met?Asp?Gly?Thr?Leu?Leu?Asn?Thr?His?His?Glu?Val?Pro?Glu?Lys

25 30 35

ttt?tgg?gac?atc?ctg?gaa?caa?atg?cgt?gcc?aaa?gga?atc?gcc?ttc?gca 259

Phe?Trp?Asp?Ile?Leu?Glu?Gln?Met?Arg?Ala?Lys?Gly?Ile?Ala?Phe?Ala

40 45 50

cca?gcc?agc?ggc?cgt?caa?tta?gcc?acc?ttg?caa?aaa?caa?ttc?ggg?cac 307

Pro?Ala?Ser?Gly?Arg?Gln?Leu?Ala?Thr?Leu?Gln?Lys?Gln?Phe?Gly?His

55 60 65

gcg?ggt?gaa?ccc?att?tct?tac?atc?gca?gaa?aac?ggc?acc?gtg?gta?gtc 355

Ala?Gly?Glu?Pro?Ile?Ser?Tyr?Ile?Ala?Glu?Asn?Gly?Thr?Val?Val?Val

70 75 80 85

cac?gac?ggc?gaa?att?atc?tcc?ctg?acc?acc?atc?gac?tcc?gac?acc?gta 403

His?Asp?Gly?Glu?Ile?Ile?Ser?Leu?Thr?Thr?Ile?Asp?Ser?Asp?Thr?Val

90 95 100

cac?tcc?atc?atc?gat?gcc?gtg?cgc?gca?tcc?gac?atc?gat?atg?gga?gta 451

His?Ser?Ile?Ile?Asp?Ala?Val?Arg?Ala?Ser?Asp?Ile?Asp?Met?Gly?Val

105 110 115

gtg?gtc?tgc?cga?cca?gaa?cgc?gcc?tac?gtc?gaa?cgc?aac?gac?gaa?gct 499

Val?Val?Cys?Arg?Pro?Glu?Arg?Ala?Tyr?Val?Glu?Arg?Asn?Asp?Glu?Ala

120 125 130

ttc?cgc?gcc?gaa?ggc?ctg?aaa?tac?tac?gtc?tcc?atc?gag?gaa?gtc?caa 547

Phe?Arg?Ala?Glu?Gly?Leu?Lys?Tyr?Tyr?Val?Ser?Ile?Glu?Glu?Val?Gln

135 140 145

gac?ctc?cac?gaa?gca?gtc?aac?aat?gaa?gta?atc?aag?gta?gcg?atc?ttt 595

Asp?Leu?His?Glu?Ala?Val?Asn?Asn?Glu?Val?Ile?Lys?Val?Ala?Ile?Phe

150 155 160 165

aca?ttc?caa?gat?gcc?gaa?aag?gac?tgt?gcc?ccc?atc?atc?cgc?gca?gcc 643

Thr?Phe?Gln?Asp?Ala?Glu?Lys?Asp?Cys?Ala?Pro?Ile?Ile?Arg?Ala?Ala

170 175 180

tcc?ccc?aac?gcc?aac?gtt?gtt?gtc?tcc?ggc?cag?cac?tgg?gtc?gat?gtc 691

Ser?Pro?Asn?Ala?Asn?Val?Val?Val?Ser?Gly?Gln?His?Trp?Val?Asp?Val

185 190 195

atg?gat?cct?tca?gcc?aac?aag?ggc?caa?gct?ttg?gct?gct?ctc?cgc?gat 739

Met?Asp?Pro?Ser?Ala?Asn?Lys?Gly?Gln?Ala?Leu?Ala?Ala?Leu?Arg?Asp

200 205 210

gcc?ctc?gga?ttg?gaa?gaa?tcc?caa?act?ctc?gtg?ttt?ggc?gac?tac?ctc 787

Ala?Leu?Gly?Leu?Glu?Glu?Ser?Gln?Thr?Leu?Val?Phe?Gly?Asp?Tyr?Leu

215 220 225

aac?gac?act?gaa?ttg?atc?aag?gcc?gcc?ggc?aag?tct?tac?gcc?atg?tcc 835

Asn?Asp?Thr?Glu?Leu?Ile?Lys?Ala?Ala?Gly?Lys?Ser?Tyr?Ala?Met?Ser

230 235 240 245

aat?gcc?cac?ccg?gac?att?ttg?gaa?ttg?gcc?gac?gaa?att?gca?cca?tcc 883

Asn?Ala?His?Pro?Asp?Ile?Leu?Glu?Leu?Ala?Asp?Glu?Ile?Ala?Pro?Ser

250 255 260

aac?att?gaa?gag?ggc?gtt?att?gtg?gtg?ctg?gag?aag?ttg?ctt?aac?ggt 931

Asn?Ile?Glu?Glu?Gly?Val?Ile?Val?Val?Leu?Glu?Lys?Leu?Leu?Asn?Gly

265 270 275

taacgattgc?aggcagcagg?ttc 954

<210>216

<211>277

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>216

Met?Gly?Asp?Gln?Asp?Ile?Ile?Gly?Lys?Glu?Ser?Lys?Gln?Met?Asp?Phe

1 5 10 15

Arg?Leu?Val?Ala?Thr?Asp?Met?Asp?Gly?Thr?Leu?Leu?Asn?Thr?His?His

20 25 30

Glu?Val?Pro?Glu?Lys?Phe?Trp?Asp?Ile?Leu?Glu?Gln?Met?Arg?Ala?Lys

35 40 45

Gly?Ile?Ala?Phe?Ala?Pro?Ala?Ser?Gly?Arg?Gln?Leu?Ala?Thr?Leu?Gln

50 55 60

Lys?Gln?Phe?Gly?His?Ala?Gly?Glu?Pro?Ile?Ser?Tyr?Ile?Ala?Glu?Asn

65 70 75 80

Gly?Thr?Val?Val?Val?His?Asp?Gly?Glu?Ile?Ile?Ser?Leu?Thr?Thr?Ile

85 90 95

Asp?Ser?Asp?Thr?Val?His?Ser?Ile?Ile?Asp?Ala?Val?Arg?Ala?Ser?Asp

100 105 110

Ile?Asp?Met?Gly?Val?Val?Val?Cys?Arg?Pro?Glu?Arg?Ala?Tyr?Val?Glu

115 120 125

Arg?Asn?Asp?Glu?Ala?Phe?Arg?Ala?Glu?Gly?Leu?Lys?Tyr?Tyr?Val?Ser

130 135 140

Ile?Glu?Glu?Val?Gln?Asp?Leu?His?Glu?Ala?Val?Asn?Asn?Glu?Val?Ile

145 150 155 160

Lys?Val?Ala?Ile?Phe?Thr?Phe?Gln?Asp?Ala?Glu?Lys?Asp?Cys?Ala?Pro

165 170 175

Ile?Ile?Arg?Ala?Ala?Ser?Pro?Asn?Ala?Asn?Val?Val?Val?Ser?Gly?Gln

180 185 190

His?Trp?Val?Asp?Val?Met?Asp?Pro?Ser?Ala?Asn?Lys?Gly?Gln?Ala?Leu

195 200 205

Ala?Ala?Leu?Arg?Asp?Ala?Leu?Gly?Leu?Glu?Glu?Ser?Gln?Thr?Leu?Val

210 215 220

Phe?Gly?Asp?Tyr?Leu?Asn?Asp?Thr?Glu?Leu?Ile?Lys?Ala?Ala?Gly?Lys

225 230 235 240

Ser?Tyr?Ala?Met?Ser?Asn?Ala?His?Pro?Asp?Ile?Leu?Glu?Leu?Ala?Asp

245 250 255

Glu?Ile?Ala?Pro?Ser?Asn?Ile?Glu?Glu?Gly?Val?Ile?Val?Val?Leu?Glu

260 265 270

Lys?Leu?Leu?Asn?Gly

275

<210>217

<211>1066

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1066)

<223>RXN00866

<400>217

gcatcaacgt?aggagatcct?cgacttccaa?ttatggctcc?aaatgagcag?gaacttgagg 60

ctctccgaga?agacatgaaa?aaagctggag?ttctataaat?atg?aat?gat?tcc?cga 115

Met?Asn?Asp?Ser?Arg

1 5

aat?cgc?ggc?cgg?aag?gtt?acc?cgc?aag?gcg?ggc?cca?cca?gaa?gct?ggt 163

Asn?Arg?Gly?Arg?Lys?Val?Thr?Arg?Lys?Ala?Gly?Pro?Pro?Glu?Ala?Gly

10 l5 20

cag?gaa?aac?cat?ctg?gat?acc?cct?gtc?ttt?cag?gca?cca?gat?gct?tcc 211

Gln?Glu?Asn?His?Leu?Asp?Thr?Pro?Val?Phe?Gln?Ala?Pro?Asp?Ala?Ser

25 30 35

tct?aac?cag?agc?gct?gta?aaa?gct?gag?acc?gcc?gga?aac?gac?aat?cgg 259

Ser?Asn?Gln?Ser?Ala?Val?Lys?Ala?Glu?Thr?Ala?Gly?Asn?Asp?Asn?Arg

40 45 50

gat?gct?gcg?caa?ggt?gct?caa?gga?tcc?caa?gat?tct?cag?ggt?tcc?cag 307

Asp?Ala?Ala?Gln?Gly?Ala?Gln?Gly?Ser?Gln?Asp?Ser?Gln?Gly?Ser?Gln

55 60 65

aac?gct?caa?ggt?tcc?cag?aac?cgc?gag?tcc?gga?aac?aac?aac?cgc?aac 355

Asn?Ala?Gln?Gly?Ser?Gln?Asn?Arg?Glu?Ser?Gly?Asn?Asn?Asn?Arg?Asn

70 75 80 85

cgt?tcc?aac?aac?aac?cgt?cgc?ggt?ggt?cgt?gga?cgt?cgt?gga?tcc?gga 403

Arg?Ser?Asn?Asn?Asn?Arg?Arg?Gly?Gly?Arg?Gly?Arg?Arg?Gly?Ser?Gly

90 95 100

aac?gcc?aat?gag?ggc?gcg?aac?aac?aac?agc?ggt?aac?cag?aac?cgt?cag 451

Asn?Ala?Asn?Glu?Gly?Ala?Asn?Asn?Asn?Ser?Gly?Asn?Gln?Asn?Arg?Gln

105 110 115

ggc?gga?aac?cgt?ggc?aac?cgc?ggt?ggc?gga?cgc?cga?aac?gtt?gtt?aag 499

Gly?Gly?Asn?Arg?Gly?Asn?Arg?Gly?Gly?Gly?Arg?Arg?Asn?Val?Val?Lys

120 125 130

tcg?atg?cag?ggt?gcg?gat?ctg?acc?cag?cgc?ctg?cca?gag?cca?cca?aag 547

Ser?Met?Gln?Gly?Ala?Asp?Leu?Thr?Gln?Arg?Leu?Pro?Glu?Pro?Pro?Lys

135 140 145

gca?ccg?gca?aac?ggt?ctg?cgt?att?tac?gca?ctt?ggt?ggc?att?tcc?gaa 595

Ala?Pro?Ala?Asn?Gly?Leu?Arg?Ile?Tyr?Ala?Leu?Gly?Gly?Ile?Ser?Glu

150 155 160 165

atc?ggt?cgc?aac?atg?acc?gtg?ttt?gag?tac?aac?aac?cgt?ctg?ctc?atc 643

Ile?Gly?Arg?Asn?Met?Thr?Val?Phe?Glu?Tyr?Asn?Asn?Arg?Leu?Leu?Ile

170 175 180

gtg?gac?tgt?ggt?gtg?ctc?ttc?cca?tct?tca?ggt?gag?cca?ggc?gtt?gac 691

Val?Asp?Cys?Gly?Val?Leu?Phe?Pro?Ser?Ser?Gly?Glu?Pro?Gly?Val?Asp

185 190 195

ctg?att?ctt?cct?gac?ttc?ggc?cca?att?gag?gat?cac?ctg?cac?cgc?gtc 739

Leu?Ile?Leu?Pro?Asp?Phe?Gly?Pro?Ile?Glu?Asp?His?Leu?His?Arg?Val

200 205 210

gat?gca?ttg?gtg?gtt?act?cac?gga?cac?gaa?gac?cac?att?ggt?gct?att 787

Asp?Ala?Leu?Val?Val?Thr?His?Gly?His?Glu?Asp?His?Ile?Gly?Ala?Ile

215 220 225

ccc?tgg?ctg?ctg?aag?ctg?cgc?aac?gat?atc?cca?atc?ttg?gca?tcc?cgt 835

Pro?Trp?Leu?Leu?Lys?Leu?Arg?Asn?Asp?Ile?Pro?Ile?Leu?Ala?Ser?Arg

230 235 240 245

ttc?acc?ttg?gct?ctg?att?gca?gct?aag?tgt?aag?gaa?cac?cgt?cag?cgt 883

Phe?Thr?Leu?Ala?Leu?Ile?Ala?Ala?Lys?Cys?Lys?Glu?His?Arg?Gln?Arg

250 255 260

ccg?aag?ctg?atc?gag?gtc?aac?gag?cag?tcc?aat?gag?gac?cgc?gga?ccg 931

Pro?Lys?Leu?Ile?Glu?Val?Asn?Glu?Gln?Ser?Asn?Glu?Asp?Arg?Gly?Pro

265 270 275

ttc?aac?att?cgc?ttc?tgg?gct?gtt?aac?cac?tcc?atc?cca?gac?tgc?ctt 979

Phe?Asn?Ile?Arg?Phe?Trp?Ala?Val?Asn?His?Ser?Ile?Pro?Asp?Cys?Leu

280 285 290

ggt?ctt?gct?atc?aag?act?cct?gct?ggt?ttg?gtc?atc?cac?acc?ggt?gac 1027

Gly?Leu?Ala?Ile?Lys?Thr?Pro?Ala?Gly?Leu?Val?Ile?His?Thr?Gly?Asp

295 300 305

atc?aag?ctg?gat?cag?act?cct?cct?gat?gga?cgc?cca?act 1066

Ile?Lys?Leu?Asp?Gln?Thr?Pro?Pro?Asp?Gly?Arg?Pro?Thr

310 315 320

<210>218

<211>322

<212>PRT

＜213〉Corynebacterium glutamicum (C0rynebacterium glutamicum)

<400>218

Met?Asn?Asp?Ser?Arg?Asn?Arg?Gly?Arg?Lys?Val?Thr?Arg?Lys?Ala?Gly

1 5 10 15

Pro?Pro?Glu?Ala?Gly?Gln?Glu?Asn?His?Leu?Asp?Thr?Pro?Val?Phe?Gln

20 25 30

Ala?Pro?Asp?Ala?Ser?Ser?Asn?Gln?Ser?Ala?Val?Lys?Ala?Glu?Thr?Ala

35 40 45

Gly?Asn?Asp?Asn?Arg?Asp?Ala?Ala?Gln?Gly?Ala?Gln?Gly?Ser?Gln?Asp

50 55 60

Ser?Gln?Gly?Ser?Gln?Asn?Ala?Gln?Gly?Ser?Gln?Asn?Arg?Glu?Ser?Gly

65 70 75 80

Asn?Asn?Asn?Arg?Asn?Arg?Ser?Asn?Asn?Asn?Arg?Arg?Gly?Gly?Arg?Gly

85 90 95

Arg?Arg?Gly?Ser?Gly?Asn?Ala?Asn?Glu?Gly?Ala?Asn?Asn?Asn?Ser?Gly

100 105 110

Asn?Gln?Asn?Arg?Gln?Gly?Gly?Asn?Arg?Gly?Asn?Arg?Gly?Gly?Gly?Arg

115 120 125

Arg?Asn?Val?Val?Lys?Ser?Met?Gln?Gly?Ala?Asp?Leu?Thr?Gln?Arg?Leu

l30 135 140

Pro?Glu?Pro?Pro?Lys?Ala?Pro?Ala?Asn?Gly?Leu?Arg?Ile?Tyr?Ala?Leu

145 150 155 160

Gly?Gly?Ile?Ser?Glu?Ile?Gly?Arg?Asn?Met?Thr?Val?Phe?Glu?Tyr?Asn

165 170 175

Asn?Arg?Leu?Leu?Ile?Val?Asp?Cys?Gly?Val?Leu?Phe?Pro?Ser?Ser?Gly

180 185 190

Glu?Pro?Gly?Val?Asp?Leu?Ile?Leu?Pro?Asp?Phe?Gly?Pro?Ile?Glu?Asp

195 200 205

His?Leu?His?Arg?Val?Asp?Ala?Leu?Val?Val?Thr?His?Gly?His?Glu?Asp

210 215 220

His?Ile?Gly?Ala?Ile?Pro?Trp?Leu?Leu?Lys?Leu?Arg?Asn?Asp?Ile?Pro

225 230 235 240

Ile?Leu?Ala?Ser?Arg?Phe?Thr?Leu?Ala?Leu?Ile?Ala?Ala?Lys?Cys?Lys

245 250 255

Glu?His?Arg?Gln?Arg?Pro?Lys?Leu?Ile?Glu?Val?Asn?Glu?Gln?Ser?Asn

260 265 270

Glu?Asp?Arg?Gly?Pro?Phe?Asn?Ile?Arg?Phe?Trp?Ala?Val?Asn?His?Ser

275 280 285

Ile?Pro?Asp?Cys?Leu?Gly?Leu?Ala?Ile?Lys?Thr?Pro?Ala?Gly?Leu?Val

290 295 300

Ile?His?Thr?Gly?Asp?Ile?Lys?Leu?Asp?Gln?Thr?Pro?Pro?Asp?Gly?Arg

305 310 315 320

Pro?Thr

<210>219

<211>1045

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1045)

<223>FRXA00866

<400>219

gcatcaacgt?aggagatcct?cgacttccaa?ttatggctcc?aaatgagcag?gaacttgagg 60

ctctccgaga?agacatgaaa?aaagctggag?ttctataaat?atg?aat?gat?tcc?cga 115

Met?Asn?Asp?Ser?Arg

1 5

aat?cgc?ggc?cgg?aag?gtt?acc?cgc?aag?gcg?ggc?cca?cca?gaa?gct?ggt 163

Asn?Arg?Gly?Arg?Lys?Val?Thr?Arg?Lys?Ala?Gly?Pro?Pro?Glu?Ala?Gly

10 15 20

cag?gaa?aac?cat?ctg?gat?acc?cct?gtc?ttt?cag?gca?cca?gat?gct?tcc 211

Gln?Glu?Asn?His?Leu?Asp?Thr?Pro?Val?Phe?Gln?Ala?Pro?Asp?Ala?Ser

25 30 35

tct?aac?cag?agc?gct?gta?aaa?gct?gag?acc?gcc?gga?aac?gac?aat?cgg 259

Ser?Asn?Gln?Ser?Ala?Val?Lys?Ala?Glu?Thr?Ala?Gly?Asn?Asp?Asn?Arg

40 45 50

gat?gct?gcg?caa?ggt?get?caa?gga?tcc?caa?gat?tet?cag?ggt?tcc?cag 307

Asp?Ala?Ala?Gln?Gly?Ala?Gln?Gly?Ser?Gln?Asp?Ser?Gln?Gly?Ser?Gln

55 60 65

aac?gct?caa?ggt?tcc?cag?aac?cgc?gag?tcc?gga?aac?aac?aac?cgc?aac 355

Asn?Ala?Gln?Gly?Ser?Gln?Asn?Arg?Glu?Ser?Gly?Asn?Asn?Asn?Arg?Asn

70 75 80 85

cgt?tcc?aac?aac?aac?cgt?cgc?ggt?ggt?cgt?gga?cgt?cgt?gga?tcc?gga 403

Arg?Ser?Asn?Asn?Asn?Arg?Arg?Gly?Gly?Arg?Gly?Arg?Arg?Gly?Ser?Gly

90 95 100

aac?gcc?aat?gag?ggc?gcg?aac?aac?aac?agc?ggt?aac?cag?aac?cgt?cag 451

Asn?Ala?Asn?Glu?Gly?Ala?Asn?Asn?Asn?Ser?Gly?Asn?Gln?Asn?Arg?Gln

105 110 115

ggc?gga?aac?cgt?ggc?aac?cgc?ggt?ggc?gga?cgc?cga?aac?gtt?gtt?aag 499

Gly?Gly?Asn?Arg?Gly?Asn?Arg?Gly?Gly?Gly?Arg?Arg?Asn?Val?Val?Lys

120 125 130

tcg?atg?cag?ggt?gcg?gat?ctg?acc?cag?cgc?ctg?cca?gag?cca?cca?aag 547

Ser?Met?Gln?Gly?Ala?Asp?Leu?Thr?Gln?Arg?Leu?Pro?Glu?Pro?Pro?Lys

135 140 145

gca?ccg?gca?aac?ggt?ctg?cgt?att?tac?gca?ctt?ggt?ggc?att?tcc?gaa 595

Ala?Pro?Ala?Asn?Gly?Leu?Arg?Ile?Tyr?Ala?Leu?Gly?Gly?Ile?Ser?Glu

150 155 160 165

atc?ggt?cgc?aac?atg?acc?gtg?ttt?gag?tac?aac?aac?cgt?ctg?ctc?atc 643

Ile?Gly?Arg?Asn?Met?Thr?Val?Phe?Glu?Tyr?Asn?Asn?Arg?Leu?Leu?Ile

170 175 180

gtg?gac?tgt?ggt?gtg?ctc?ttc?cca?tct?tca?ggt?gag?cca?ggc?gtt?gac 691

Val?Asp?Cys?Gly?Val?Leu?Phe?Pro?Ser?Ser?Gly?Glu?Pro?Gly?Val?Asp

185 190 195

ctg?att?ctt?cct?gac?ttc?ggc?cca?att?gag?gat?cac?ctg?cac?cgc?gtc 739

Leu?Ile?Leu?Pro?Asp?Phe?Gly?Pro?Ile?Glu?Asp?His?Leu?His?Arg?Val

200 205 210

gat?gca?ttg?gtg?gtt?act?cac?gga?cac?gaa?gac?cac?att?ggt?gct?att 787

Asp?Ala?Leu?Val?Val?Thr?His?Gly?His?Glu?Asp?His?Ile?Gly?Ala?Ile

215 220 225

ccc?tgg?ctg?ctg?aag?ctg?cgc?aac?gat?atc?cca?atc?ttg?gca?tcc?cgt 835

Pro?Trp?Leu?Leu?Lys?Leu?Arg?Asn?Asp?Ile?Pro?Ile?Leu?Ala?Ser?Arg

230 235 240 245

ttc?acc?ttg?gct?ctg?att?gca?gct?aag?tgt?aag?gaa?cac?cgt?cag?cgt 883

Phe?Thr?Leu?Ala?Leu?Ile?Ala?Ala?Lys?Cys?Lys?Glu?His?Arg?Gln?Arg

250 255 260

ccg?aag?ctg?atc?gag?gtc?aac?gag?cag?tcc?aat?gag?gac?cgc?gga?ecg 931

Pro?Lys?Leu?Ile?Glu?Val?Asn?Glu?Gln?Ser?Asn?Glu?Asp?Arg?Gly?Pro

265 270 275

ttc?aac?att?cgc?ttc?tgg?gct?gtt?aac?cac?tcc?atc?cca?gac?tgc?ctt 979

Phe?Asn?Ile?Arg?Phe?Trp?Ala?Val?Asn?His?Ser?Ile?Pro?Asp?Cys?Leu

280 285 290

ggt?ctt?gct?atc?aag?act?cct?gct?ggt?ttg?gtc?atc?cac?acc?ggt?gac 1027

Gly?Leu?Ala?Ile?Lys?Thr?Pro?Ala?Gly?Leu?Val?Ile?His?Thr?Gly?Asp

295 300 305

atc?aag?ctg?gat?cag?act 1045

Ile?Lys?Leu?Asp?Gln?Thr

310 315

<210>220

<211>315

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>220

Met?Asn?Asp?Ser?Arg?Asn?Arg?Gly?Arg?Lys?Val?Thr?Arg?Lys?Ala?Gly

1 5 10 15

Pro?Pro?Glu?Ala?Gly?Gln?Glu?Asn?His?Leu?Asp?Thr?Pro?Val?Phe?Gln

20 25 30

Ala?Pro?Asp?Ala?Ser?Ser?Asn?Gln?Ser?Ala?Val?Lys?Ala?Glu?Thr?Ala

35 40 45

Gly?Asn?Asp?Asn?Arg?Asp?Ala?Ala?Gln?Gly?Ala?Gln?Gly?Ser?Gln?Asp

50 55 60

Ser?Gln?Gly?Ser?Gln?Asn?Ala?Gln?Gly?Ser?Gln?Asn?Arg?Glu?Ser?Gly

65 70 75 80

Asn?Asn?Asn?Arg?Asn?Arg?Ser?Asn?Asn?Asn?Arg?Arg?Gly?Gly?Arg?Gly

85 90 95

Arg?Arg?Gly?Ser?Gly?Asn?Ala?Asn?Glu?Gly?Ala?Asn?Asn?Asn?Ser?Gly

100 105 110

Asn?Gln?Asn?Arg?Gln?Gly?Gly?Asn?Arg?Gly?Asn?Arg?Gly?Gly?Gly?Arg

115 120 125

Arg?Asn?Val?Val?Lys?Ser?Met?Gln?Gly?Ala?Asp?Leu?Thr?Gln?Arg?Leu

130 135 140

Pro?Glu?Pro?Pro?Lys?Ala?Pro?Ala?Asn?Gly?Leu?Arg?Ile?Tyr?Ala?Leu

145 150 155 160

Gly?Gly?Ile?Ser?Glu?Ile?Gly?Arg?Asn?Met?Thr?Val?Phe?Glu?Tyr?Asn

165 170 175

Asn?Arg?Leu?Leu?Ile?Val?Asp?Cys?Gly?Val?Leu?Phe?Pro?Ser?Ser?Gly

180 185 190

Glu?Pro?Gly?Val?Asp?Leu?Ile?Leu?Pro?Asp?Phe?Gly?Pro?Ile?Glu?Asp

195 200 205

His?Leu?His?Arg?Val?Asp?Ala?Leu?Val?Val?Thr?His?Gly?His?Glu?Asp

210 215 220

His?Ile?Gly?Ala?Ile?Pro?Trp?Leu?Leu?Lys?Leu?Arg?Asn?Asp?Ile?Pro

225 230 235 240

Ile?Leu?Ala?Ser?Arg?Phe?Thr?Leu?Ala?Leu?Ile?Ala?Ala?Lys?Cys?Lys

245 250 255

Glu?His?Arg?Gln?Arg?Pro?Lys?Leu?Ile?Glu?Val?Asn?Glu?Gln?Ser?Asn

260 265 270

Glu?Asp?Arg?Gly?Pro?Phe?Asn?Ile?Arg?Phe?Trp?Ala?Val?Asn?His?Ser

275 280 285

Ile?Pro?Asp?Cys?Leu?Gly?Leu?Ala?Ile?Lys?Thr?Pro?Ala?Gly?Leu?Val

290 295 300

Ile?His?Thr?Gly?Asp?Ile?Lys?Leu?Asp?Gln?Thr

305 310 315

<210>221

<211>789

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(766)

<223>RXA02410

<400>221

tatgagactg?accatccttg?gaagctctgg?tagcgtgccc?gctccaggta?accccgcatc 60

cggatatctg?ttaacttctc?cggacgcccc?tgccgtgatt?atg?gac?atg?ggc?cca 115

Met?Asp?Met?Gly?Pro

1 5

ggt?gtc?ctt?gca?gca?gtt?caa?gaa?att?caa?gat?cct?gct?gat?gcg?cat 163

Gly?Val?Leu?Ala?Ala?Val?Gln?Glu?Ile?Gln?Asp?Pro?Ala?Asp?Ala?His

10 15 20

gtt?att?ttc?tcc?cat?ttg?cac?acc?gat?cac?tgc?gct?gat?ttt?gcg?tcc 211

Val?Ile?Phe?Ser?His?Leu?His?Thr?Asp?His?Cys?Ala?Asp?Phe?Ala?Ser

25 30 35

ttg?atg?gtg?tgg?cgc?agg?ttc?cac?cca?acg?ctg?gcc?gcc?aag?agc?cgc 259

Leu?Met?Val?Trp?Arg?Arg?Phe?His?Pro?Thr?Leu?Ala?Ala?Lys?Ser?Arg

40 45 50

aat?ctt?ttg?ttt?gga?cct?gaa?gat?acc?ccc?aac?agg?ctt?ggt?cgt?ttg 307

Asn?Leu?Leu?Phe?Gly?Pro?Glu?Asp?Thr?Pro?Asn?Arg?Leu?Gly?Arg?Leu

55 60 65

agc?tcc?gat?gag?cct?gat?ggc?gtt?gac?gat?atg?tca?gat?act?ttt?gct 355

Ser?Ser?Asp?Glu?Pro?Asp?Gly?Val?Asp?Asp?Met?Ser?Asp?Thr?Phe?Ala

70 75 80 85

ttc?gac?gcc?tgg?gaa?gag?cgc?aag?cca?gag?ctc?att?gat?aat?ttc?acg 403

Phe?Asp?Ala?Trp?Glu?Glu?Arg?Lys?Pro?Glu?Leu?Ile?Asp?Asn?Phe?Thr

90 95 100

gtc?acg?ccg?ttc?cgc?gtt?gtg?cac?ccc?att?gag?acc?tac?gcg?ctt?cgc 451

Val?Thr?Pro?Phe?Arg?Val?Val?His?Pro?Ile?Glu?Thr?Tyr?Ala?Leu?Arg

105 110 115

gta?gag?gag?cac?cgc?acc?ggc?gcc?tca?att?acg?tat?tcc?ggt?gac?agc 499

Val?Glu?Glu?His?Arg?Thr?Gly?Ala?Ser?Ile?Thr?Tyr?Ser?Gly?Asp?Ser

120 125 130

gcg?tac?acc?gaa?gcg?ctt?atc?gac?gcc?gcc?cgc?aac?gtt?gac?att?ttc 547

Ala?Tyr?Thr?Glu?Ala?Leu?Ile?Asp?Ala?Ala?Arg?Asn?Val?Asp?Ile?Phe

135 140 145

ttg?tgc?gag?gca?act?tgg?ggc?acc?tct?tgc?gat?gac?aaa?gca?cca?gga 595

Leu?Cys?Glu?Ala?Thr?Trp?Gly?Thr?Ser?Cys?Asp?Asp?Lys?Ala?Pro?Gly

150 155 160 165

atg?cat?atg?tgt?ggc?caa?gac?gcc?gga?aga?att?gcg?gca?gca?gct?ggc 643

Met?His?Met?Cys?Gly?Gln?Asp?Ala?Gly?Arg?Ile?Ala?Ala?Ala?Ala?Gly

170 175 180

gta?aag?aaa?ctg?att?atc?act?cat?gtt?cca?cca?tgg?att?gat?gca?gag 691

Val?Lys?Lys?Leu?Ile?Ile?Thr?His?Val?Pro?Pro?Trp?Ile?Asp?Ala?Glu

185 190 195

gcc?aca?gtg?gca?gca?gct?gcg?gaa?cac?ttt?gat?ggt?cct?atc?gaa?ttg 739

Ala?Thr?Val?Ala?Ala?Ala?Ala?Glu?His?Phe?Asp?Gly?Pro?Ile?Glu?Leu

200 205 210

gca?cga?tca?gga?atg?gtt?atc?gag?ttt?tagtccgttt?gtactaataa 786

Ala?Arg?Ser?Gly?Met?Val?Ile?Glu?Phe

215 220

ggt 789

<210>222

<211>222

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>222

Met?Asp?Met?Gly?Pro?Gly?Val?Leu?Ala?Ala?Val?Gln?Glu?Ile?Gln?Asp

1 5 10 15

Pro?Ala?Asp?Ala?His?Val?Ile?Phe?Ser?His?Leu?His?Thr?Asp?His?Cys

20 25 30

Ala?Asp?Phe?Ala?Ser?Leu?Met?Val?Trp?Arg?Arg?Phe?His?Pro?Thr?Leu

35 40 45

Ala?Ala?Lys?Ser?Arg?Asn?Leu?Leu?Phe?Gly?Pro?Glu?Asp?Thr?Pro?Asn

50 55 60

Arg?Leu?Gly?Arg?Leu?Ser?Ser?Asp?Glu?Pro?Asp?Gly?Val?Asp?Asp?Met

65 70 75 80

Ser?Asp?Thr?Phe?Ala?Phe?Asp?Ala?Trp?Glu?Glu?Arg?Lys?Pro?Glu?Leu

85 90 95

Ile?Asp?Asn?Phe?Thr?Val?Thr?Pro?Phe?Arg?Val?Val?His?Pro?Ile?Glu

100 105 110

Thr?Tyr?Ala?Leu?Arg?Val?Glu?Glu?His?Arg?Thr?Gly?Ala?Ser?Ile?Thr

115 120 125

Tyr?Ser?Gly?Asp?Ser?Ala?Tyr?Thr?Glu?Ala?Leu?Ile?Asp?Ala?Ala?Arg

130 135 140

Asn?Val?Asp?Ile?Phe?Leu?Cys?Glu?Ala?Thr?Trp?Gly?Thr?Ser?Cys?Asp

145 150 155 160

Asp?Lys?Ala?Pro?Gly?Met?His?Met?Cys?Gly?Gln?Asp?Ala?Gly?Arg?Ile

165 170 175

Ala?Ala?Ala?Ala?Gly?Val?Lys?Lys?Leu?Ile?Ile?Thr?His?Val?Pro?Pro

180 185 190

Trp?Ile?Asp?Ala?Glu?Ala?Thr?Val?Ala?Ala?Ala?Ala?Glu?His?Phe?Asp

195 200 205

Gly?Pro?Ile?Glu?Leu?Ala?Arg?Ser?Gly?Met?Val?Ile?Glu?Phe

210 215 220

<210>223

<211>455

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(432)

<223>RXA00961

<400>223

cta?gag?aac?tgg?cgt?atc?ggc?cgc?atg?ttg?ctg?ctt?ggc?gac?gcc?gcc 48

Leu?Glu?Asn?Trp?Arg?Ile?Gly?Arg?Met?Leu?Leu?Leu?Gly?Asp?Ala?Ala

1 5 10 15

cac?gca?ccc?ctc?cag?tac?ctc?gcc?tca?ggc?gcg?gtc?atg?gcc?atg?gaa 96

His?Ala?Pro?Leu?Gln?Tyr?Leu?Ala?Ser?Gly?Ala?Val?Met?Ala?Met?Glu

20 25 30

gac?gcc?gag?gct?gtc?gcc?ctc?ttc?gct?gcc?gac?gct?gcg?cgt?gct?ggc 144

Asp?Ala?Glu?Ala?Val?Ala?Leu?Phe?Ala?Ala?Asp?Ala?Ala?Arg?Ala?Gly

35 40 45

aac?ctc?gat?tgg?gaa?gag?gta?ctc?gca?gag?gtg?gaa?gct?gaa?cgc?cga 192

Asn?Leu?Asp?Trp?Glu?Glu?Val?Leu?Ala?Glu?Val?Glu?Ala?Glu?Arg?Arg

50 55 60

cca?cgc?tgc?agc?cgc?atc?caa?acc?gta?ggc?cgt?ttc?tgg?gga?gag?ctc 240

Pro?Arg?Cys?Ser?Arg?Ile?Gln?Thr?Val?Gly?Arg?Phe?Trp?Gly?Glu?Leu

65 70 75 80

tgg?cat?gtg?gaa?ggc?acc?gca?cgt?ctc?atc?cgc?aac?gaa?gtt?ttc?cgc 288

Trp?His?Val?Glu?Gly?Thr?Ala?Arg?Leu?Ile?Arg?Asn?Glu?Val?Phe?Arg

85 90 95

caa?gca?gac?cgc?aat?ggc?tgg?ttc?atc?tat?gca?gac?tgg?ctg?tgg?ggt 336

Gln?Ala?Asp?Arg?Asn?Gly?Trp?Phe?Ile?Tyr?Ala?Asp?Trp?Leu?Trp?Gly

100 105 110

tac?gat?gca?tcc?aag?cgt?gcc?cac?atc?gcc?aac?cct?gag?ctc?gga?gaa 384

Tyr?Asp?Ala?Ser?Lys?Arg?Ala?His?Ile?Ala?Asn?Pro?Glu?Leu?Gly?Glu

115 120 125

atg?cca?caa?gca?ctg?aag?gaa?tgg?cgc?tac?gcc?ctc?ctc?gaa?cag?aaa 432

Met?Pro?Gln?Ala?Leu?Lys?Glu?Trp?Arg?Tyr?Ala?Leu?Leu?Glu?Gln?Lys

130 135 140

tagcagcctc?acctgttaag?gga 455

<210>224

<211>144

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>224

Leu?Glu?Asn?Trp?Arg?Ile?Gly?Arg?Met?Leu?Leu?Leu?Gly?Asp?Ala?Ala

1 5 10 15

His?Ala?Pro?Leu?Gln?Tyr?Leu?Ala?Ser?Gly?Ala?Val?Met?Ala?Met?Glu

20 25 30

Asp?Ala?Glu?Ala?Val?Ala?Leu?Phe?Ala?Ala?Asp?Ala?Ala?Arg?Ala?Gly

35 40 45

Asn?Leu?Asp?Trp?Glu?Glu?Val?Leu?Ala?Glu?Val?Glu?Ala?Glu?Arg?Arg

50 55 60

Pro?Arg?Cys?Ser?Arg?Ile?Gln?Thr?Val?Gly?Arg?Phe?Trp?Gly?Glu?Leu

65 70 75 80

Trp?His?Val?Glu?Gly?Thr?Ala?Arg?Leu?Ile?Arg?Asn?Glu?Val?Phe?Arg

85 90 95

Gln?Ala?Asp?Arg?Asn?Gly?Trp?Phe?Ile?Tyr?Ala?Asp?Trp?Leu?Trp?Gly

100 105 110

Tyr?Asp?Ala?Ser?Lys?Arg?Ala?His?Ile?Ala?Asn?Pro?Glu?Leu?Gly?Glu

115 120 125

Met?Pro?Gln?Ala?Leu?Lys?Glu?Trp?Arg?Tyr?Ala?Leu?Leu?Glu?Gln?Lys

130 135 140

<210>225

<211>1116

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1093)

<223>RXA00111

<400>225

ccgagaagct?ggagaaggcc?aacaagcgtg?gcctctacac?ctccgcgtcc?ttccacagcc 60

ccggcgccat?cactggcgac?cactaaaaaa?ggagacttcg?atg?gcc?ttt?ttt?agc 115

Met?Ala?Phe?Phe?Ser

1 5

ttt?tcg?acg?tct?ccc?ctc?acc?cgc?ctc?atc?ccc?ggc?agc?cgc?tcc?aaa 163

Phe?Ser?Thr?Ser?Pro?Leu?Thr?Arg?Leu?Ile?Pro?Gly?Ser?Arg?Ser?Lys

10 15 20

gcc?aca?ggc?gcc?aaa?cgg?cgc?ctg?agc?agc?aca?atc?gcg?tcg?att?gaa 211

Ala?Thr?Gly?Ala?Lys?Arg?Arg?Leu?Ser?Ser?Thr?Ile?Ala?Ser?Ile?Glu

25 30 35

cgc?tcc?ccc?ggc?atc?att?gcc?cta?gac?gga?ccg?ttc?acc?cac?gat?cac 259

Arg?Ser?Pro?Gly?Ile?Ile?Ala?Leu?Asp?Gly?Pro?Phe?Thr?His?Asp?His

40 45 50

gtc?tcc?gta?cgt?ggc?att?cgc?ctc?cat?tta?gca?gag?gca?ggc?tcc?ccc 307

Val?Ser?Val?Arg?Gly?Ile?Arg?Leu?His?Leu?Ala?Glu?Ala?Gly?Ser?Pro

55 60 65

acc?aaa?ccc?ctg?gtt?ctt?ctg?atc?cac?ggg?gct?ttc?ggc?ggt?tgg?tac 355

Thr?Lys?Pro?Leu?Val?Leu?Leu?Ile?His?Gly?Ala?Phe?Gly?Gly?Trp?Tyr

70 75 80 85

gac?tac?cgc?gaa?gtc?atc?ggc?cca?ctc?gca?gat?gcc?ggc?ttc?cac?gtc 403

Asp?Tyr?Arg?Glu?Val?Ile?Gly?Pro?Leu?Ala?Asp?Ala?Gly?Phe?His?Val

90 95 100

gcc?gcc?atc?gat?cta?cgc?ggc?tac?ggc?atg?tcc?gac?aaa?ccc?cca?aca 451

Ala?Ala?Ile?Asp?Leu?Arg?Gly?Tyr?Gly?Met?Ser?Asp?Lys?Pro?Pro?Thr

105 110 115

ggc?tac?gac?ctc?cgc?cac?gca?gcc?gga?gaa?ctc?agc?agc?gtt?atc?gca 499

Gly?Tyr?Asp?Leu?Arg?His?Ala?Ala?Gly?Glu?Leu?Ser?Ser?Val?Ile?Ala

120 125 130

gct?ctc?ggc?cac?gat?gac?gca?ctt?ctt?gtc?ggc?tcc?gac?acc?ggc?gcc 547

Ala?Leu?Gly?His?Asp?Asp?Ala?Leu?Leu?Val?Gly?Ser?Asp?Thr?Gly?Ala

135 140 145

agc?atc?gcc?tgg?gct?atc?gct?tcc?atg?tac?ccc?gaa?cgg?gtc?cgc?ggc 595

Ser?Ile?Ala?Trp?Ala?Ile?Ala?Ser?Met?Tyr?Pro?Glu?Arg?Val?Arg?Gly

150 155 160 165

cta?att?tcc?ctc?ggc?gcg?atc?cac?ccc?ctt?gac?atg?cga?cgc?gcc?atc 643

Leu?Ile?Ser?Leu?Gly?Ala?Ile?His?Pro?Leu?Asp?Met?Arg?Arg?Ala?Ile

170 175 180

cga?cga?aaa?ccc?cac?cta?cac?gtc?tct?gac?ctc?agc?cga?ctt?gct?cct 691

Arg?Arg?Lys?Pro?His?Leu?His?Val?Ser?Asp?Leu?Ser?Arg?Leu?Ala?Pro

185 190 195

ttt?cgg?ttg?ccc?tca?ttc?ctg?cat?aac?ctc?ttc?cac?ttc?gga?atc?acc 739

Phe?Arg?Leu?Pro?Ser?Phe?Leu?His?Asn?Leu?Phe?His?Phe?Gly?Ile?Thr

200 205 210

agc?gaa?gct?cga?cgt?gag?atc?gtc?aac?aac?acg?tcc?tcg?tcc?tac?cag 787

Ser?Glu?Ala?Arg?Arg?Glu?Ile?Val?Asn?Asn?Thr?Ser?Ser?Ser?Tyr?Gln

215 220 225

cgc?agc?aac?gca?ttc?aca?gag?aca?gtg?ctc?ctc?cgc?aaa?aaa?gca?cta 835

Arg?Ser?Asn?Ala?Phe?Thr?Glu?Thr?Val?Leu?Leu?Arg?Lys?Lys?Ala?Leu

230 235 240 245

tcg?atc?gac?cac?acc?atc?acc?ccg?atc?atc?cgc?acc?aac?cgc?tac?ctc 883

Ser?Ile?Asp?His?Thr?Ile?Thr?Pro?Ile?Ile?Arg?Thr?Asn?Arg?Tyr?Leu

250 255 260

gtt?ggg?tcg?atc?ccc?agc?aaa?aca?gtc?tcc?gca?ccg?gtg?tgg?ctg?ctc 931

Val?Gly?Ser?Ile?Pro?Ser?Lys?Thr?Val?Ser?Ala?Pro?Val?Trp?Leu?Leu

265 270 275

aga?acc?aac?act?cga?cgc?tgg?gaa?cat?cta?gcc?aat?act?gcg?cgc?act 979

Arg?Thr?Asn?Thr?Arg?Arg?Trp?Glu?His?Leu?Ala?Asn?Thr?Ala?Arg?Thr

280 285 290

cga?acg?aca?ggg?cca?ttc?acc?acc?atc?gcg?atc?ccc?ggc?ggc?tac?gaa 1027

Arg?Thr?Thr?Gly?Pro?Phe?Thr?Thr?Ile?Ala?Ile?Pro?Gly?Gly?Tyr?Glu

295 300 305

ctc?ccc?tac?ctc?gag?aac?cct?tcc?gaa?ttt?gca?gca?acc?atc?gca?gag 1075

Leu?Pro?Tyr?Leu?Glu?Asn?Pro?Ser?Glu?Phe?Ala?Ala?Thr?Ile?Ala?Glu

310 315 320 325

ttc?gcg?cgc?acc?acg?ttt?taagcactgt?ggctgaggcg?ctg 1116

Phe?Ala?Arg?Thr?Thr?Phe

330

<210>226

<211>331

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>226

Met?Ala?Phe?Phe?Ser?Phe?Ser?Thr?Ser?Pro?Leu?Thr?Arg?Leu?Ile?Pro

1 5 10 15

Gly?Ser?Arg?Ser?Lys?Ala?Thr?Gly?Ala?Lys?Arg?Arg?Leu?Ser?Ser?Thr

20 25 30

Ile?Ala?Ser?Ile?Glu?Arg?Ser?Pro?Gly?Ile?Ile?Ala?Leu?Asp?Gly?Pro

35 40 45

Phe?Thr?His?Asp?His?Val?Ser?Val?Arg?Gly?Ile?Arg?Leu?His?Leu?Ala

50 55 60

Glu?Ala?Gly?Ser?Pro?Thr?Lys?Pro?Leu?Val?Leu?Leu?Ile?His?Gly?Ala

65 70 75 80

Phe?Gly?Gly?Trp?Tyr?Asp?Tyr?Arg?Glu?Val?Ile?Gly?Pro?Leu?Ala?Asp

85 90 95

Ala?Gly?Phe?His?Val?Ala?Ala?Ile?Asp?Leu?Arg?Gly?Tyr?Gly?Met?Ser

100 105 110

Asp?Lys?Pro?Pro?Thr?Gly?Tyr?Asp?Leu?Arg?His?Ala?Ala?Gly?Glu?Leu

115 120 125

Ser?Ser?Val?Ile?Ala?Ala?Leu?Gly?His?Asp?Asp?Ala?Leu?Leu?Val?Gly

130 135 140

Ser?Asp?Thr?Gly?Ala?Ser?Ile?Ala?Trp?Ala?Ile?Ala?Ser?Met?Tyr?Pro

145 150 155 160

Glu?Arg?Val?Arg?Gly?Leu?Ile?Ser?Leu?Gly?Ala?Ile?His?Pro?Leu?Asp

165 170 175

Met?Arg?Arg?Ala?Ile?Arg?Arg?Lys?Pro?His?Leu?His?Val?Ser?Asp?Leu

180 185 190

Ser?Arg?Leu?Ala?Pro?Phe?Arg?Leu?Pro?Ser?Phe?Leu?His?Asn?Leu?Phe

195 200 205

His?Phe?Gly?Ile?Thr?Ser?Glu?Ala?Arg?Arg?Glu?Ile?Val?Asn?Asn?Thr

210 215 220

Ser?Ser?Ser?Tyr?Gln?Arg?Ser?Asn?Ala?Phe?Thr?Glu?Thr?Val?Leu?Leu

225 230 235 240

Arg?Lys?Lys?Ala?Leu?Ser?Ile?Asp?His?Thr?Ile?Thr?Pro?Ile?Ile?Arg

245 250 255

Thr?Asn?Arg?Tyr?Leu?Val?Gly?Ser?Ile?Pro?Ser?Lys?Thr?Val?Ser?Ala

260 265 270

Pro?Val?Trp?Leu?Leu?Arg?Thr?Asn?Thr?Arg?Arg?Trp?Glu?His?Leu?Ala

275 280 285

Asn?Thr?Ala?Arg?Thr?Arg?Thr?Thr?Gly?Pro?Phe?Thr?Thr?Ile?Ala?Ile

290 295 300

Pro?Gly?Gly?Tyr?Glu?Leu?Pro?Tyr?Leu?Glu?Asn?Pro?Ser?Glu?Phe?Ala

305 310 315 320

Ala?Thr?Ile?Ala?Glu?Phe?Ala?Arg?Thr?Thr?Phe

325 330

<210>227

<211>1020

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(997)

<223>RXA01932

<400>227

tttctaacct?gcatccaagc?ctaggtggaa?ttgagatgac?gcgtcgtaga?gatcgaaaac 60

tcaaccaaat?ttcttgccta?aggcttctag?gattgtcgtt?atg?ctc?ctt?cac?cea 115

Met?Leu?Leu?His?Pro

1 5

gat?gcg?cag?ttt?tat?atc?gat?acc?ttg?ccc?act?ctc?agc?gcg?gag?gag 163

Asp?Ala?Gln?Phe?Tyr?Ile?Asp?Thr?Leu?Pro?Thr?Leu?Ser?Ala?Glu?Glu

10 15 20

cag?gtg?agt?ttt?ggt?aaa?gac?gct?cct?gtt?tca?gag?gct?gat?gca?acc 211

Gln?Val?Ser?Phe?Gly?Lys?Asp?Ala?Pro?Val?Ser?Glu?Ala?Asp?Ala?Thr

25 30 35

cat?gtg?gcg?aca?gat?caa?gat?att?gct?ggg?gtg?ccg?gtg?agg?gtt?tat 259

His?Val?Ala?Thr?Asp?Gln?Asp?Ile?Ala?Gly?Val?Pro?Val?Arg?Val?Tyr

40 45 50

acg?cct?tta?tct?ggg?gct?ggg?gat?ttg?ccg?tgt?ttg?gtg?tacttc?cac 307

Thr?Pro?Leu?Ser?Gly?Ala?Gly?Asp?Leu?Pro?Cys?Leu?Val?Tyr?Phe?His

55 60 65

ggc?ggt?ggc?tgg?tcc?ggc?ggc?acc?ctc?aac?atg?atc?gat?gcc?acg?gtt 355

Gly?Gly?Gly?Trp?Ser?Gly?Gly?Thr?Leu?Asn?Met?Ile?Asp?Ala?Thr?Val

70 75 80 85

cac?tct?cta?gtg?gtt?ggc?ctg?ccg?atc?atc?gcc?atc?agc?gtg?gac?tac 403

His?Ser?Leu?Val?Val?Gly?Leu?Pro?Ile?Ile?Ala?Ile?Ser?Val?Asp?Tyr

90 95 100

cga?ctt?gca?ccc?gca?cac?cca?ttt?cca?gcg?gct?atc?gac?gac?gcg?ttt 451

Arg?Leu?Ala?Pro?Ala?His?Pro?Phe?Pro?Ala?Ala?Ile?Asp?Asp?Ala?Phe

105 110 115

gca?gtg?gtc?agt?gcc?gta?ttg?gat?ggg?gtg?tct?ggg?ctg?agt?att?gat 499

Ala?Val?Val?Ser?Ala?Val?Leu?Asp?Gly?Val?Ser?Gly?Leu?Ser?Ile?Asp

120 125 130

act?tcc?cga?gtg?gca?att?ggc?ggt?gac?agt?gcc?ggt?gga?aat?att?gcc 547

Thr?Ser?Arg?Val?Ala?Ile?Gly?Gly?Asp?Ser?Ala?Gly?Gly?Asn?Ile?Ala

135 140 145

gcg?gtt?act?gca?caa?cag?ctg?cgt?gaa?cgg?gct?gtg?ggt?tct?act?cct 595

Ala?Val?Thr?Ala?Gln?Gln?Leu?Arg?Glu?Arg?Ala?Val?Gly?Ser?Thr?Pro

150 155 160 165

gta?ttg?gct?cac?cag?gtg?ctt?att?ttt?ccg?gta?act?gat?gtt?tcc?act 643

Val?Leu?Ala?His?Gln?Val?Leu?Ile?Phe?Pro?Val?Thr?Asp?Val?Ser?Thr

170 175 180

aca?tct?acg?ccg?agc?tat?ctc?aca?ttt?ggc?aaa?gat?tgc?tac?ctg?aca 691

Thr?Ser?Thr?Pro?Ser?Tyr?Leu?Thr?Phe?Gly?Lys?Asp?Cys?Tyr?Leu?Thr

185 190 195

aag?gac?gcg?atg?gaa?cgc?tac?atc?gaa?caa?tat?gcc?gat?ggg?cac?gac 739

Lys?Asp?Ala?Met?Glu?Arg?Tyr?Ile?Glu?Gln?Tyr?Ala?Asp?Gly?His?Asp

200 205 210

cgc?acc?gac?cct?cga?ctc?tca?ccg?cta?ctg?gca?tct?gat?ttg?agc?gac 787

Arg?Thr?Asp?Pro?Arg?Leu?Ser?Pro?Leu?Leu?Ala?Ser?Asp?Leu?Ser?Asp

215 220 225

ctc?cca?ccc?acc?acc?att?gtg?tac?ggc?gaa?tgc?gac?gtg?tta?gcc?cat 835

Leu?Pro?Pro?Thr?Thr?Ile?Val?Tyr?Gly?Glu?Cys?Asp?Val?Leu?Ala?His

230 235 240 245

gaa?gtg?cga?gcc?tat?gga?caa?gct?cta?cta?gag?gct?gga?aat?tcc?gtg 883

Glu?Val?Arg?Ala?Tyr?Gly?Gln?Ala?Leu?Leu?Glu?Ala?Gly?Asn?Ser?Val

250 255 260

acg?atg?act?gaa?ttc?aaa?gga?cag?atc?cac?gcc?ttt?att?aac?cta?ggg 931

Thr?Met?Thr?Glu?Phe?Lys?Gly?Gln?Ile?His?Ala?Phe?Ile?Asn?Leu?Gly

265 270 275

gga?atc?agt?tcc?gat?gcg?cgg?gct?gct?cga?cga?ctc?atc?cgc?gcc?gaa 979

Gly?Ile?Ser?Ser?Asp?Ala?Arg?Ala?Ala?Arg?Arg?Leu?Ile?Arg?Ala?Glu

280 285 290

ttg?gaa?gca?gca?ctt?tgt?taaaggttga?gatttaacat?tcg 1020

Leu?Glu?Ala?Ala?Leu?Cys

295

<210>228

<211>299

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>228

Met?Leu?Leu?His?Pro?Asp?Ala?Gln?Phe?Tyr?Ile?Asp?Thr?Leu?Pro?Thr

1 5 10 15

Leu?Ser?Ala?Glu?Glu?Gln?Val?Ser?Phe?Gly?Lys?Asp?Ala?Pro?Val?Ser

20 25 30

Glu?Ala?Asp?Ala?Thr?His?Val?Ala?Thr?Asp?Gln?Asp?Ile?Ala?Gly?Val

35 40 45

Pro?Val?Arg?Val?Tyr?Thr?Pro?Leu?Ser?Gly?Ala?Gly?Asp?Leu?Pro?Cys

50 55 60

Leu?Val?Tyr?Phe?His?Gly?Gly?Gly?Trp?Ser?Gly?Gly?Thr?Leu?Asn?Met

65 70 75 80

Ile?Asp?Ala?Thr?Val?His?Ser?Leu?Val?Val?Gly?Leu?Pro?Ile?Ile?Ala

85 90 95

Ile?Ser?Val?Asp?Tyr?Arg?Leu?Ala?Pro?Ala?His?Pro?Phe?Pro?Ala?Ala

100 105 110

Ile?Asp?Asp?Ala?Phe?Ala?Val?Val?Ser?Ala?Val?Leu?Asp?Gly?Val?Ser

115 120 125

Gly?Leu?Ser?Ile?Asp?Thr?Ser?Arg?Val?Ala?Ile?Gly?Gly?Asp?Ser?Ala

130 135 140

Gly?Gly?Asn?Ile?Ala?Ala?Val?Thr?Ala?Gln?Gln?Leu?Arg?Glu?Arg?Ala

145 150 155 160

ValGly?Ser?Thy?Pro?Val?Leu?Ala?His?Gln?Val?Leu?Ile?Phe?Pro?Val

165 170 175

Thr?Asp?Val?Ser?Thr?Thr?Ser?Thr?Pro?Ser?Tyr?Leu?Thr?Phe?Gly?Lys

180 185 190

Asp?Cys?Tyr?Leu?Thr?Lys?Asp?Ala?Met?Glu?Arg?Tyr?Ile?Glu?Gln?Tyr

195 200 205

Ala?Asp?Gly?His?Asp?Arg?Thr?Asp?Pro?Arg?Leu?Ser?Pro?Leu?Leu?Ala

210 215 220

Ser?Asp?Leu?Ser?Asp?Leu?Pro?Pro?Thr?Thr?Ile?Val?Tyr?Gly?Glu?Cys

225 230 235 240

Asp?Val?Leu?Ala?His?Glu?Val?Arg?Ala?Tyr?Gly?Gln?Ala?Leu?Leu?Glu

245 250 255

Ala?Gly?Asn?Ser?Val?Thr?Met?Thr?Glu?Phe?Lys?Gly?Gln?Ile?His?Ala

260 265 270

Phe?Ile?Asn?Leu?Gly?Gly?Ile?Ser?Ser?Asp?Ala?Arg?Ala?Ala?Arg?Arg

275 280 285

Leu?Ile?Arg?Ala?Glu?Leu?Glu?Ala?Ala?Leu?Cys

290 295

<210>229

<211>1131

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1108)

<223>RXA02574

<400>229

tgtgctcctt?gcgggctgcg?cagaagagcc?ggaacagcaa?aaagcaataa?gccgcttatc 60

gacgtccccc?tccacccctc?ccgcaccgac?cgcggaggat?ttg?gcg?cgc?gcg?caa 115

Leu?Ala?Arg?Ala?Gln

1 5

atc?cct?gaa?cag?caa?cgc?gac?caa?gtc?gcg?tcg?ctg?atg?atg?gtt?gga 163

Ile?Pro?Glu?Gln?Gln?Arg?Asp?Gln?Val?Ala?Ser?Leu?Met?Met?Val?Gly

10 15 20

gtt?gcg?aat?tat?gat?cag?gca?ttg?gat?gcg?ctc?aat?cag?ggg?gtg?ggt 211

Val?Ala?Asn?Tyr?Asp?Gln?Ala?Leu?Asp?Ala?Leu?Asn?Gln?Gly?Val?Gly

25 30 35

ggc?atc?ttt?att?ggt?tcc?tgg?aca?gat?gaa?aat?ctg?ctc?acg?gaa?cct 259

Gly?Ile?Phe?Ile?Gly?Ser?Trp?Thr?Asp?Glu?Asn?Leu?Leu?Thr?Glu?Pro

40 45 50

ggc?cgt?aat?att?gag?gcg?ctc?cgc?gaa?gcc?gtc?ggc?agg?gat?ttc?tcc 307

Gly?Arg?Asn?Ile?Glu?Ala?Leu?Arg?Glu?Ala?Val?Gly?Arg?Asp?Phe?Ser

55 60 65

gtc?agc?atc?gac?ttc?gaa?ggc?ggc?cgc?gtc?cag?cgt?gcc?acc?aat?att 355

Val?Ser?Ile?Asp?Phe?Glu?Gly?Gly?Arg?Val?Gln?Arg?Ala?Thr?Asn?Ile

70 75 80 85

ctt?ggt?gat?ttc?ccc?tca?ccg?cgc?gtg?atg?gcg?caa?acc?atg?acg?ccg 403

Leu?Gly?Asp?Phe?Pro?Ser?Pro?Arg?Val?Met?Ala?Gln?Thr?Met?Thr?Pro

90 95 100

gaa?caa?gta?gaa?gat?ctc?gca?gaa?atc?cta?ggc?act?ggt?tta?gct?gca 451

Glu?Gln?Val?Glu?Asp?Leu?Ala?Glu?Ile?Leu?Gly?Thr?Gly?Leu?Ala?Ala

105 110 115

cat?ggt?gtg?aca?gtt?aac?ttt?gca?cct?gtt?gta?gat?gta?gat?gct?tgg 499

His?Gly?Val?Thr?Val?Asn?Phe?Ala?Pro?Val?Val?Asp?Val?Asp?Ala?Trp

120 125 130

ggt?ctc?ccc?gtc?gtt?ggc?gat?cgt?tcc?ttt?tcc?aac?gac?cca?gcc?gta 547

Gly?Leu?Pro?Val?Val?Gly?Asp?Arg?Ser?Phe?Ser?Asn?Asp?Pro?Ala?Val

135 140 145

gca?gct?act?tat?gcc?aca?gct?ttt?gca?aag?ggc?tta?agc?aaa?gta?gga 595

Ala?Ala?Thr?Tyr?Ala?Thr?Ala?Phe?Ala?Lys?Gly?Leu?Ser?Lys?Val?Gly

150 155 160 165

att?acc?cca?gta?ttc?aaa?cat?ttc?cca?ggt?cac?ggt?cgt?gca?agt?ggc 643

Ile?Thr?Pro?Val?Phe?Lys?His?Phe?Pro?Gly?His?Gly?Arg?Ala?Ser?Gly

170 175 180

gat?tcg?cac?acc?caa?gat?gtg?gtg?acc?ccc?gca?ctt?gat?gag?ctt?aaa 691

Asp?Ser?His?Thr?Gln?Asp?Val?Val?Thr?Pro?Ala?Leu?Asp?Glu?Leu?Lys

185 190 195

act?tac?gac?ctc?atc?cct?tat?ggt?caa?gca?ctt?tct?gaa?act?gac?gga 739

Thr?Tyr?Asp?Leu?Ile?Pro?Tyr?Gly?Gln?Ala?Leu?Ser?Glu?Thr?Asp?Gly

200 205 210

gcc?gtc?atg?gtg?ggc?cac?atg?att?gtt?cca?ggt?ctt?ggc?acc?gac?gga 787

Ala?Val?Met?Val?Gly?His?Met?Ile?Val?Pro?Gly?Leu?Gly?Thr?Asp?Gly

215 220 225

gtt?cca?tcc?tct?atc?gac?ccc?gcc?acc?tat?caa?ctg?ctc?cgc?agt?ggc 835

Val?Pro?Ser?Ser?Ile?Asp?Pro?Ala?Thr?Tyr?Gln?Leu?Leu?Arg?Ser?Gly

230 235 240 245

gat?tac?cca?ggt?ggc?gtg?cct?ttc?gat?ggc?gtg?atc?tac?acc?gac?gat 883

Asp?Tyr?Pro?Gly?Gly?Val?Pro?Phe?Asp?Gly?Val?Ile?Tyr?Thr?Asp?Asp

250 255 260

ctc?tct?gga?atg?agt?gcc?att?tcc?gcc?acc?cat?tca?ccc?gca?gaa?gca 931

Leu?Ser?Gly?Met?Ser?Ala?Ile?Ser?Ala?Thr?His?Ser?Pro?Ala?Glu?Ala

265 270 275

gtg?ctt?gcc?tcc?ctc?aaa?gca?ggc?gca?gac?caa?gca?cta?tgg?atc?gac 979

Val?Leu?Ala?Ser?Leu?Lys?Ala?Gly?Ala?Asp?Gln?Ala?Leu?Trp?Ile?Asp

280 285 290

tat?ggg?tcg?ttg?ggc?tcc?gcg?att?gat?cgc?gtt?gat?gct?gcc?gtt?agc 1027

Tyr?Gly?Ser?Leu?Gly?Ser?Ala?Ile?Asp?Arg?Val?Asp?Ala?Ala?Val?Ser

295 300 305

agc?ggt?gaa?tac?cct?caa?gaa?caa?atg?ctg?gca?tct?gcg?tta?aga?gtc 1075

Ser?Gly?Glu?Tyr?Pro?Gln?Glu?Gln?Met?Leu?Ala?Ser?Ala?Leu?Arg?Val

310 315 320 325

caa?ttg?ctc?tac?atc?aca?cgt?ctc?gaa?caa?aag?tgaagttacc?agtccgtaac 1128

Gln?Leu?Leu?Tyr?Ile?Thr?Arg?Leu?Glu?Gln?Lys

330 335

ccc

1131

<210>230

<211>336

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>230

Leu?Ala?Arg?Ala?Gln?Ile?Pro?Glu?Gln?Gln?Arg?Asp?Gln?Val?Ala?Ser

1 5 10 15

Leu?Met?Met?Val?Gly?Val?Ala?Asn?Tyr?Asp?Gln?Ala?Leu?Asp?Ala?Leu

20 25 30

Asn?Gln?Gly?Val?Gly?Gly?Ile?Phe?Ile?Gly?Ser?Trp?Thr?Asp?Glu?Asn

35 40 45

Leu?Leu?Thr?Glu?Pro?Gly?Arg?Asn?Ile?Glu?Ala?Leu?Arg?Glu?Ala?Val

50 55 60

Gly?Arg?Asp?Phe?Ser?Val?Ser?Ile?Asp?Phe?Glu?Gly?Gly?Arg?Val?Gln

65 70 75 80

Arg?Ala?Thr?Asn?Ile?Leu?Gly?Asp?Phe?Pro?Ser?Pro?Arg?Val?Met?Ala

85 90 95

Gln?Thr?Met?Thr?Pro?Glu?Gln?Val?Glu?Asp?Leu?Ala?Glu?Ile?Leu?Gly

100 105 110

Thr?Gly?Leu?Ala?Ala?His?Gly?Val?Thr?Val?Asn?Phe?Ala?Pro?Val?Val

115 120 125

Asp?Val?Asp?Ala?Trp?Gly?Leu?Pro?Val?Val?Gly?Asp?Arg?Ser?Phe?Ser

130 135 140

Asn?Asp?Pro?Ala?Val?Ala?Ala?Thr?Tyr?Ala?Thr?Ala?Phe?Ala?Lys?Gly

145 150 155 160

Leu?Ser?Lys?Val?Gly?Ile?Thr?Pro?Val?Phe?Lys?His?Phe?Pro?Gly?His

165 170 175

Gly?Arg?Ala?Ser?Gly?Asp?Ser?His?Thr?Gln?Asp?Val?Val?Thr?Pro?Ala

180 185 190

Leu?Asp?Glu?Leu?Lys?Thr?Tyr?Asp?Leu?Ile?Pro?Tyr?Gly?Gln?Ala?Leu

195 200 205

Ser?Glu?Thr?Asp?Gly?Ala?Val?Met?Val?Gly?His?Met?Ile?Val?Pro?Gly

210 215 220

Leu?Gly?Thr?Asp?Gly?Val?Pro?Ser?Ser?Ile?Asp?Pro?Ala?Thr?Tyr?Gln

225 230 235 240

Leu?Leu?Arg?Ser?Gly?Asp?Tyr?Pro?Gly?Gly?Val?Pro?Phe?Asp?Gly?Val

245 250 255

Ile?Tyr?Thr?Asp?Asp?Leu?Ser?Gly?Met?Ser?Ala?Ile?Ser?Ala?Thr?His

260 265 270

Ser?Pro?Ala?Glu?Ala?Val?Leu?Ala?Ser?Leu?Lys?Ala?Gly?Ala?Asp?Gln

275 280 285

Ala?Leu?Trp?Ile?Asp?Tyr?Gly?Ser?Leu?Gly?Ser?Ala?Ile?Asp?Arg?Val

290 295 300

Asp?Ala?Ala?Val?Ser?Ser?Gly?Glu?Tyr?Pro?Gln?Glu?Gln?Met?Leu?Ala

305 310 315 320

Ser?Ala?Leu?Arg?Val?Gln?Leu?Leu?Tyr?Ile?Thr?Arg?Leu?Glu?Gln?Lys

325 330 335

<210>231

<211>1599

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1576)

<223>RXN00983

<400>231

gtgagaaaac?agtggctcaa?atatcgacat?cttctactca?cagttcaacc?tgtcgtggct 60

ggaggccggc?tgcattggtg?tcgacgccga?tgaaacgtcc?gtg?act?gca?ggt?gaa 115

Val?Thr?Ala?Gly?Glu

1 5

acc?acc?act?atg?aat?gtc?acg?ttg?acc?aat?cct?ttc?gac?aac?gca?att 163

Thr?Thr?Thr?Met?Asn?Val?Thr?Leu?Thr?Asn?Pro?Phe?Asp?Asn?Ala?Ile

10 15 20

ttt?gac?cga?gca?gtc?tcc?ctt?gaa?cgt?ccc?gaa?gga?tgg?caa?gct?gag 211

Phe?Asp?Arg?Ala?Val?Ser?Leu?Glu?Arg?Pro?Glu?Gly?Trp?Gln?Ala?Glu

25 30 35

gat?gtt?cgt?gtg?tcg?atc?cca?tct?gga?gaa?tct?gtc?aca?atc?cca?gtc 259

Asp?Val?Arg?Val?Ser?Ile?Pro?Ser?Gly?Glu?Ser?Val?Thr?Ile?Pro?Val

40 45 50

cag?gtc?aca?gca?ccg?ctg?gta?gcc?gac?aac?ggt?gaa?ctt?cca?gtg?gag 307

Gln?Val?Thr?Ala?Pro?Leu?Val?Ala?Asp?Asn?Gly?Glu?Leu?Pro?Val?Glu

55 60 65

gtg?tcc?att?ctt?gat?gga?gca?gac?cgc?tac?acg?ggt?cgt?ctc?aat?ctc 355

Val?Ser?Ile?Leu?Asp?Gly?Ala?Asp?Arg?Tyr?Thr?Gly?Arg?Leu?Asn?Leu

70 75 80 85

act?gtt?cag?ggt?ggg?caa?gaa?cct?gca?cca?act?tca?gtg?aag?gtg?agc 403

Thr?Val?Gln?Gly?Gly?Gln?Glu?Pro?Ala?Pro?Thr?Ser?Val?Lys?Val?Ser

90 95 100

att?cca?aat?ctc?aag?gac?act?tat?gta?gca?ggg?gag?aag?atc?agc?att 451

Ile?Pro?Asn?Leu?Lys?Asp?Thr?Tyr?Val?Ala?Gly?Glu?Lys?Ile?Ser?Ile

105 110 115

aac?ttt?gcg?gtc?aac?aac?ccg?ttt?gac?gtt?acg?gtt?aat?tcg?gtg?cca 499

Asn?Phe?Ala?Val?Asn?Asn?Pro?Phe?Asp?Val?Thr?Val?Asn?Ser?Val?Pro

120 125 130

agc?ctg?ggg?gaa?ggc?gag?aac?tgg?atg?cct?gca?aac?cta?cgc?gga?ttt 547

Ser?Leu?Gly?Glu?Gly?Glu?Asn?Trp?Met?Pro?Ala?Asn?Leu?Arg?Gly?Phe

135 140 145

gat?cca?gag?cag?ggt?act?ccc?aac?tgt?cgt?tac?aag?aat?tta?ggc?gcg 595

Asp?Pro?Glu?Gln?Gly?Thr?Pro?Asn?Cys?Arg?Tyr?Lys?Asn?Leu?Gly?Ala

150 155 160 165

aat?aag?agc?tat?gac?tgc?acc?aca?act?acc?tat?gaa?gtc?agc?gat?ttg 643

Asn?Lys?Ser?Tyr?Asp?Cys?Thr?Thr?Thr?Thr?Tyr?Glu?Val?Ser?Asp?Leu

170 175 180

gat?gta?gaa?cgc?gga?tac?gtg?gat?att?cca?acg?gta?tgg?acg?ttt?act 691

Asp?Val?Glu?Arg?Gly?Tyr?Val?Asp?Ile?Pro?Thr?Val?Trp?Thr?Phe?Thr

185 190 195

aac?tcc?gca?ggc?gaa?acg?gta?tgg?tcc?aaa?aac?gtt?gat?gtg?cct?cga 739

Asn?Ser?Ala?Gly?Glu?Thr?Val?Trp?Ser?Lys?Asn?Val?Asp?Val?Pro?Arg

200 205 210

gtt?gaa?ctc?aat?gga?aca?cag?gat?gct?gtc?act?gat?gca?atc?gta?acg 787

Val?Glu?Leu?Asn?Gly?Thr?Gln?Asp?Ala?Val?Thr?Asp?Ala?Ile?Val?Thr

215 220 225

gtt?gat?ccc?atc?aac?cca?gtt?cat?tcc?aac?ggc?cag?agc?caa?act?gtt 835

Val?Asp?Pro?Ile?Asn?Pro?Val?His?Ser?Asn?Gly?Gln?Ser?Gln?Thr?Val

230 235 240 245

gag?gtc?cag?gct?aat?gtc?acc?tca?gag?gga?gat?ctg?cca?gct?gga?tct 883

Glu?Val?Gln?Ala?Asn?Val?Thr?Ser?Glu?Gly?Asp?Leu?Pro?Ala?Gly?Ser

250 255 260

aag?gtg?gcc?ttt?tat?cta?gat?tca?tcg?ccc?att?gat?acc?gca?gct?gtt 931

Lys?Val?Ala?Phe?Tyr?Leu?Asp?Ser?Ser?Pro?Ile?Asp?Thr?Ala?Ala?Val

265 270 275

gat?gcg?gaa?ggg?cat?gcc?agc?atc?tcg?att?gat?gtg?gac?aac?atc?gca 979

Asp?Ala?Glu?Gly?His?Ala?Ser?Ile?Ser?Ile?Asp?Val?Asp?Asn?Ile?Ala

280 285 290

agc?gag?cag?cct?gaa?cgc?aca?ttt?gag?gtt?cgc?gcc?cga?ctc?gtc?gtt 1027

Ser?Glu?Gln?Pro?Glu?Arg?Thr?Phe?Glu?Val?Arg?Ala?Arg?Leu?Val?Val

295 300 305

cca?gaa?gat?gca?cca?cga?tca?atc?gcg?cgt?gat?gcc?ttg?gca?cgt?ttt 1075

Pro?Glu?Asp?Ala?Pro?Arg?Ser?Ile?Ala?Arg?Asp?Ala?Leu?Ala?Arg?Phe

310 315 320 325

aca?gtc?ctg?tct?gaa?caa?gtg?cag?cag?aac?tcc?ttg?gtg?atc?atg?aat 1123

Thr?Val?Leu?Ser?Glu?Gln?Val?Gln?Gln?Asn?Ser?Leu?Val?Ile?Met?Asn

330 335 340

cat?cca?gat?gtg?ttt?tct?gat?gga?caa?aca?aag?act?att?gtc?atc?gca 1171

His?Pro?Asp?Val?Phe?Ser?Asp?Gly?Gln?Thr?Lys?Thr?Ile?Val?Ile?Ala

345 350 355

gcg?aag?gcg?aca?gca?cac?gat?gga?tcg?ccg?gtg?gct?atc?ggt?act?ctc 1219

Ala?Lys?Ala?Thr?Ala?His?Asp?Gly?Ser?Pro?Val?Ala?Ile?Gly?Thr?Leu

360 365 370

att?gca?ttt?cgc?gtc?aac?ggt?att?gag?cgg?gac?gtg?gtt?cca?act?aac 1267

Ile?Ala?Phe?Arg?Val?Asn?Gly?Ile?Glu?Arg?Asp?Val?Val?Pro?Thr?Asn

375 380 385

gcg?caa?gga?aca?gca?aag?ctt?cag?cta?gac?ctc?aag?cca?gta?aat?act 1315

Ala?Gln?Gly?Thr?Ala?Lys?Leu?Gln?Leu?Asp?Leu?Lys?Pro?Val?Asn?Thr

390 395 400 405

gaa?gac?gag?gaa?tat?gaa?gta?aca?gtt?gaa?gcc?gag?ctg?gat?gaa?ttg 1363

Glu?Asp?Glu?Glu?Tyr?Glu?Val?Thr?Val?Glu?Ala?Glu?Leu?Asp?Glu?Leu

410 415 420

act?gct?cag?acc?acg?ttc?aaa?gta?ctt?gct?ggt?gag?gaa?gag?gaa?ccc 1411

Thr?Ala?Gln?Thr?Thr?Phe?Lys?Val?Leu?Ala?Gly?Glu?Glu?Glu?Glu?Pro

425 430 435

acc?agc?acc?gaa?gaa?caa?ccg?tca?gaa?act?gag?cag?cct?tct?gaa?cct 1459

Thr?Ser?Thr?Glu?Glu?Gln?Pro?Ser?Glu?Thr?Glu?Gln?Pro?Ser?Glu?Pro

440 445 450

gaa?gag?gaa?tcg?act?ggt?gtt?gct?gga?agc?tct?aac?ggt?ggc?agt?ttt 1507

Glu?Glu?Glu?Ser?Thr?Gly?Val?Ala?Gly?Ser?Ser?Asn?Gly?Gly?Ser?Phe

455 460 465

gtc?gcg?ctt?tta?gcg?ctg?ctg?gca?gcg?ctt?ggt?ggc?atc?gtc?ggt?gca 1555

Val?Ala?Leu?Leu?Ala?Leu?Leu?Ala?Ala?Leu?Gly?Gly?Ile?Val?Gly?Ala

470 475 480 485

gtc?ctc?gga?ttg?ctt?aag?ttg?taggtggctg?ggggcgtcga?aaa 1599

Val?Leu?Gly?Leu?Leu?Lys?Leu

490

<210>232

<211>492

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>232

Val?Thr?Ala?Gly?Glu?Thr?Thr?Thr?Met?Asn?Val?Thr?Leu?Thr?Asn?Pro

1 5 10 15

Phe?Asp?Asn?Ala?Ile?Phe?Asp?Arg?Ala?Val?Ser?Leu?Glu?Arg?Pro?Glu

20 25 30

Gly?Trp?Gln?Ala?Glu?Asp?Val?Arg?Val?Ser?Ile?Pro?Ser?Gly?Glu?Ser

35 40 45

Val?Thr?Ile?Pro?Val?Gln?Val?Thr?Ala?Pro?Leu?Val?Ala?Asp?Asn?Gly

50 55 60

Glu?Leu?Pro?Val?Glu?Val?Ser?Ile?Leu?Asp?Gly?Ala?Asp?Arg?Tyr?Thr

65 70 75 80

Gly?Arg?Leu?Asn?Leu?Thr?Val?Gln?Gly?Gly?Gln?Glu?Pro?Ala?Pro?Thr

85 90 95

Ser?Val?Lys?Val?Ser?Ile?Pro?Asn?Leu?Lys?Asp?Thr?Tyr?Val?Ala?Gly

100 105 110

Glu?Lys?Ile?Ser?Ile?Asn?Phe?Ala?Val?Asn?Asn?Pro?Phe?Asp?Val?Thr

115 120 125

Val?Asn?Ser?Val?Pro?Ser?Leu?Gly?Glu?Gly?Glu?Asn?Trp?Met?Pro?Ala

130 135 140

Asn?Leu?Arg?Gly?Phe?Asp?Pro?Glu?Gln?Gly?Thr?Pro?Asn?Cys?Arg?Tyr

145 150 155 160

Lys?Asn?Leu?Gly?Ala?Asn?Lys?Ser?Tyr?Asp?Cys?Thr?Thr?Thr?Thr?Tyr

165 170 175

Glu?Val?Ser?Asp?Leu?Asp?Val?Glu?Arg?Gly?Tyr?Val?Asp?Ile?Pro?Thr

180 185 190

Val?Trp?Thr?Phe?Thr?Asn?Ser?Ala?Gly?Glu?Thr?Val?Trp?Ser?Lys?Asn

195 200 205

Val?Asp?Val?Pro?Arg?Val?Glu?Leu?Asn?Gly?Thr?Gln?Asp?Ala?Val?Thr

210 215 220

Asp?Ala?Ile?Val?Thr?Val?Asp?Pro?Ile?Asn?Pro?Val?His?Ser?Asn?Gly

225 230 235 240

Gln?Ser?Gln?Thr?Val?Glu?Val?Gln?Ala?Asn?Val?Thr?Ser?Glu?Gly?Asp

245 250 255

Leu?Pro?Ala?Gly?Ser?Lys?Val?Ala?Phe?Tyr?Leu?Asp?Ser?Ser?Pro?Ile

260 265 270

Asp?Thr?Ala?Ala?Val?Asp?Ala?Glu?Gly?His?Ala?Ser?Ile?Ser?Ile?Asp

275 280 285

Val?Asp?Asn?Ile?Ala?Ser?Glu?Gln?Pro?Glu?Arg?Thr?Phe?Glu?Val?Arg

290 295 300

Ala?Arg?Leu?Val?Val?Pro?Glu?Asp?Ala?Pro?Arg?Ser?Ile?Ala?Arg?Asp

305 310 315 320

Ala?Leu?Ala?Arg?Phe?Thr?Val?Leu?Ser?Glu?Gln?Val?Gln?Gln?Asn?Ser

325 330 335

Leu?Val?Ile?Met?Asn?His?Pro?Asp?Val?Phe?Ser?Asp?Gly?Gln?Thr?Lys

340 345 350

Thr?Ile?Val?Ile?Ala?Ala?Lys?Ala?Thr?Ala?His?Asp?Gly?Ser?Pro?Val

355 360 365

Ala?Ile?Gly?Thr?Leu?Ile?Ala?Phe?Arg?Val?Asn?Gly?Ile?Glu?Arg?Asp

370 375 380

Val?Val?Pro?Thr?Asn?Ala?Gln?Gly?Thr?Ala?Lys?Leu?Gln?Leu?Asp?Leu

385 390 395 400

Lys?Pro?Val?Asn?Thr?Glu?Asp?Glu?Glu?Tyr?Glu?Val?Thr?Val?Glu?Ala

405 410 415

Glu?Leu?Asp?Glu?Leu?Thr?Ala?Gln?Thr?Thr?Phe?Lys?Val?Leu?Ala?Gly

420 425 430

Glu?Glu?Glu?Glu?Pro?Thr?Ser?Thr?Glu?Glu?Gln?Pro?Ser?Glu?Thr?Glu

435 440 445

Gln?Pro?Ser?Glu?Pro?Glu?Glu?Glu?Ser?Thr?Gly?Val?Ala?Gly?Ser?Ser

450 455 460

Asn?Gly?Gly?Ser?Phe?Val?Ala?Leu?Leu?Ala?Leu?Leu?Ala?Ala?Leu?Gly

465 470 475 480

Gly?Ile?Val?Gly?Ala?Val?Leu?Gly?Leu?Leu?Lys?Leu

485 490

<210>233

<211>1297

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1297)

<223>FRXA00983

<400>233

gtgagaaaac?agtggctcaa?atatcgacat?cttctactca?cagttcaacc?tgtcgtggct 60

ggaggccggc?tgcattggtg?tcgacgccga?tgaaacgtcc?gtg?act?gca?ggt?gaa 115

Val?Thr?Ala?Gly?Glu

1 5

acc?acc?act?atg?aat?gtc?acg?ttg?acc?aat?cct?ttc?gac?aac?gca?att 163

Thr?Thr?Thr?Met?Asn?Val?Thr?Leu?Thr?Asn?Pro?Phe?Asp?Asn?Ala?Ile

10 15 20

ttt?gac?cga?gca?gtc?tcc?ctt?gaa?cgt?ccc?gaa?gga?tgg?caa?gct?gag 211

Phe?Asp?Arg?Ala?Val?Ser?Leu?Glu?Arg?Pro?Glu?Gly?Trp?Gln?Ala?Glu

25 30 35

gat?gtt?cgt?gtg?tcg?atc?cca?tct?gga?gaa?tct?gtc?aca?atc?cca?gtc 259

Asp?Val?Arg?Val?Ser?Ile?Pro?Ser?Gly?Glu?Ser?Val?Thr?Ile?Pro?Val

40 45 50

cag?gtc?aca?gca?ccg?ctg?gta?gcc?gac?aac?ggt?gaa?ctt?cca?gtg?gag 307

Gln?Val?Thr?Ala?Pro?Leu?Val?Ala?Asp?Asn?Gly?Glu?Leu?Pro?Val?Glu

55 60 65

gtg?tcc?att?ctt?gat?gga?gca?gac?cgc?tac?acg?ggt?cgt?ctc?aat?ctc 355

Val?Ser?Ile?Leu?Asp?Gly?Ala?Asp?Arg?Tyr?Thr?Gly?Arg?Leu?Asn?Leu

70 75 80 85

act?gtt?cag?ggt?ggg?caa?gaa?cct?gca?cca?act?tca?gtg?aag?gtg?agc 403

Thr?Val?Gln?Gly?Gly?Gln?Glu?Pro?Ala?Pro?Thr?Ser?Val?Lys?Val?Ser

90 95 100

att?cca?aat?ctc?aag?gac?act?tat?gta?gca?ggg?gag?aag?atc?agc?att 451

Ile?Pro?Asn?Leu?Lys?Asp?Thr?Tyr?Val?Ala?Gly?Glu?Lys?Ile?Ser?Ile

105 110 115

aac?ttt?gcg?gtc?aac?aac?ccg?ttt?gac?gtt?acg?gtt?aat?tcg?gtg?cca 499

Asn?Phe?Ala?Val?Asn?Asn?Pro?Phe?Asp?Val?Thr?Val?Asn?Ser?Val?Pro

120 125 130

agc?ctg?ggg?gaa?ggc?gag?aac?tgg?atg?cct?gca?aac?cta?cgc?gga?ttt 547

Ser?Leu?Gly?Glu?Gly?Glu?Asn?Trp?Met?Pro?Ala?Asn?Leu?Arg?Gly?Phe

135 140 145

gat?cca?gag?cag?ggt?act?ccc?aac?tgt?cgt?tac?aag?aat?tta?ggc?gcg 595

Asp?Pro?Glu?Gln?Gly?Thr?Pro?Asn?Cys?Arg?Tyr?Lys?Asn?Leu?Gly?Ala

150 155 160 165

aat?aag?agc?tat?gac?tgc?acc?aca?act?acc?tat?gaa?gtc?agc?gat?ttg 643

Asn?Lys?Ser?Tyr?Asp?Cys?Thr?Thr?Thr?Thr?Tyr?Glu?Val?Ser?Asp?Leu

170 175 180

gat?gta?gaa?cgc?gga?tac?gtg?gat?att?cca?acg?gta?tgg?acg?ttt?act 691

Asp?Val?Glu?Arg?Gly?Tyr?Val?Asp?Ile?Pro?Thr?Val?Trp?Thr?Phe?Thr

185 190 195

aac?tcc?gca?ggc?gaa?acg?gta?tgg?tcc?aaa?aac?gtt?gat?gtg?cct?cga 739

Asn?Ser?Ala?Gly?Glu?Thr?Val?Trp?Ser?Lys?Asn?Val?Asp?Val?Pro?Arg

200 205 210

gtt?gaa?ctc?aat?gga?aca?cag?gat?gct?gtc?act?gat?gca?atc?gta?acg 787

Val?Glu?Leu?Asn?Gly?Thr?Gln?Asp?Ala?Val?Thr?Asp?Ala?Ile?Val?Thr

215 220 225

gtt?gat?ccc?atc?aac?cca?gtt?cat?tcc?aac?ggc?cag?agc?caa?act?gtt 835

Val?Asp?Pro?Ile?Asn?Pro?Val?His?Ser?Asn?Gly?Gln?Ser?Gln?Thr?Val

230 235 240 245

gag?gtc?cag?gct?aat?gtc?acc?tca?gag?gga?gat?ctg?cca?gct?gga?tct 883

Glu?Val?Gln?Ala?Asn?Val?Thr?Ser?Glu?Gly?Asp?Leu?Pro?Ala?Gly?Ser

250 255 260

aag?gtg?gcc?ttt?tat?cta?gat?tca?tcg?ccc?att?gat?acc?gca?gct?gtt 931

Lys?Val?Ala?Phe?Tyr?Leu?Asp?Ser?Ser?Pro?Ile?Asp?Thr?Ala?Ala?Val

265 270 275

gat?gcg?gaa?ggg?cat?gcc?agc?atc?tcg?att?gat?gtg?gac?aac?atc?gca 979

Asp?Ala?Glu?Gly?His?Ala?Ser?Ile?Ser?Ile?Asp?Val?Asp?Asn?Ile?Ala

280 285 290

agc?gag?cag?cct?gaa?cgc?aca?ttt?gag?gtt?cgc?gcc?cga?ctc?gtc?gtt 1027

Ser?Glu?Gln?Pro?Glu?Arg?Thr?Phe?Glu?Val?Arg?Ala?Arg?Leu?Val?Val

295 300 305

cca?gaa?gat?gca?cca?cga?tca?atc?gcg?cgt?gat?gcc?ttg?gca?cgt?ttt 1075

Pro?Glu?Asp?Ala?Pro?Arg?Ser?Ile?Ala?Arg?Asp?Ala?Leu?Ala?Arg?Phe

310 315 320 325

aca?gtc?ctg?tct?gaa?caa?gtg?cag?cag?aac?tcc?ttg?gtg?atc?atg?aat 1123

Thr?Val?Leu?Ser?Glu?Gln?Val?Gln?Gln?Asn?Ser?Leu?Val?Ile?Met?Asn

330 335 340

cat?cca?gat?gtg?ttt?tct?gat?gga?caa?aca?aag?act?att?gtc?atc?gca 1171

His?Pro?Asp?Val?Phe?Ser?Asp?Gly?Gln?Thr?Lys?Thr?Ile?Val?Ile?Ala

345 350 355

gcg?aag?gcg?aca?gca?cac?gat?gga?tcg?ccg?gcg?gct?atc?ggt?act?ctc 1219

Ala?Lys?Ala?Thr?Ala?His?Asp?Gly?Ser?Pro?Ala?Ala?Ile?Gly?Thr?Leu

360 365 370

att?gca?ttt?cgc?gtc?aac?ggt?att?gag?cgg?gac?gtg?gtt?cca?act?aac 1267

Ile?Ala?Phe?Arg?Val?Asn?Gly?Ile?Glu?Arg?Asp?Val?Val?Pro?Thr?Asn

375 380 385

gcg?caa?gga?aca?gca?aag?ctt?cag?cta?gac 1297

Ala?Gln?Gly?Thr?Ala?Lys?Leu?Gln?Leu?Asp

390 395

<210>234

<211>399

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>234

Val?Thr?Ala?Gly?Glu?Thr?Thr?Thr?Met?Asn?Val?Thr?Leu?Thr?Asn?Pro

1 5 10 15

Phe?Asp?Asn?Ala?Ile?Phe?Asp?Arg?Ala?Val?Ser?Leu?Glu?Arg?Pro?Glu

20 25 30

Gly?Trp?Gln?Ala?Glu?Asp?Val?Arg?Val?Ser?Ile?Pro?Ser?Gly?Glu?Ser

35 40 45

Val?Thr?Ile?Pro?Val?Gln?Val?Thr?Ala?Pro?Leu?Val?Ala?Asp?Asn?Gly

50 55 60

Glu?Leu?Pro?Val?Glu?Val?Ser?Ile?Leu?Asp?Gly?Ala?Asp?Arg?Tyr?Thr

65 70 75 80

Gly?Arg?Leu?Asn?Leu?Thr?Val?Gln?Gly?Gly?Gln?Glu?Pro?Ala?Pro?Thr

85 90 95

Ser?Val?Lys?Val?Ser?Ile?Pro?Asn?Leu?Lys?Asp?Thr?Tyr?Val?Ala?Gly

100 105 110

Glu?Lys?Ile?Ser?Ile?Asn?Phe?Ala?Val?Asn?Asn?Pro?Phe?Asp?Val?Thr

115 120 125

Val?Asn?Ser?Val?Pro?Ser?Leu?Gly?Glu?Gly?Glu?Asn?Trp?Met?Pro?Ala

130 135 140

Asn?Leu?Arg?Gly?Phe?Asp?Pro?Glu?Gln?Gly?Thr?Pro?Asn?Cys?Arg?Tyr

145 150 155 160

Lys?Asn?Leu?Gly?Ala?Asn?Lys?Ser?Tyr?Asp?Cys?Thr?Thr?Thr?Thr?Tyr

165 170 175

Glu?Val?Ser?Asp?Leu?Asp?Val?Glu?Arg?Gly?Tyr?Val?Asp?Ile?Pro?Thr

180 185 190

Val?Trp?Thr?Phe?Thr?Asn?Ser?Ala?Gly?Glu?Thr?Val?Trp?Ser?Lys?Asn

195 200 205

Val?Asp?Val?Pro?Arg?Val?Glu?Leu?Asn?Gly?Thr?Gln?Asp?Ala?Val?Thr

210 215 220

Asp?Ala?Ile?Val?Thr?Val?Asp?Pro?Ile?Asn?Pro?Val?His?Ser?Asn?Gly

225 230 235 240

Gln?Ser?Gln?Thr?Val?Glu?Val?Gln?Ala?Asn?Val?Thr?Ser?Glu?Gly?Asp

245 250 255

Leu?Pro?Ala?Gly?Ser?Lys?Val?Ala?Phe?Tyr?Leu?Asp?Ser?Ser?Pro?Ile

260 265 270

Asp?Thr?Ala?Ala?Val?Asp?Ala?Glu?Gly?His?Ala?Ser?Ile?Ser?Ile?Asp

275 280 285

Val?Asp?Asn?Ile?Ala?Ser?Glu?Gln?Pro?Glu?Arg?Thr?Phe?Glu?Val?Arg

290 295 300

Ala?Arg?Leu?Val?Val?Pro?Glu?Asp?Ala?Pro?Arg?Ser?Ile?Ala?Arg?Asp

305 310 315 320

Ala?Leu?Ala?Arg?Phe?Thr?Val?Leu?Ser?Glu?Gln?Val?Gln?Gln?Asn?Ser

325 330 335

Leu?Val?Ile?Met?Asn?His?Pro?Asp?Val?Phe?Ser?Asp?Gly?Gln?Thr?Lys

340 345 350

Thr?Ile?Val?Ile?Ala?Ala?Lys?Ala?Thr?Ala?His?Asp?Gly?Ser?Pro?Ala

355 360 365

Ala?Ile?Gly?Thr?Leu?Ile?Ala?Phe?Arg?Val?Asn?Gly?Ile?Glu?Arg?Asp

370 375 380

Val?Val?Pro?Thr?Asn?Ala?Gln?Gly?Thr?Ala?Lys?Leu?Gln?Leu?Asp

385 390 395

<210>235

<211>440

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(417)

<223>RXA00984

<400>235

caa?cgt?ggt?acc?cca?gtg?ctc?ctt?ggg?gaa?act?cca?tgg?atg?aaa?aca 48

Gln?Arg?Gly?Thr?Pro?Val?Leu?Leu?Gly?Glu?Thr?Pro?Trp?Met?Lys?Thr

1 5 10 15

aaa?atc?gtg?gaa?ctc?agc?gat?gga?acc?ctg?atg?aac?aac?agt?cgt?tca 96

Lys?Ile?Val?Glu?Leu?Ser?Asp?Gly?Thr?Leu?Met?Asn?Asn?Ser?Arg?Ser

20 25 30

tca?gga?gcc?gat?act?tac?cgc?aag?gtg?tct?tat?tcc?acc?gac?ggc?ggc 144

Ser?Gly?Ala?Asp?Thr?Tyr?Arg?Lys?Val?Ser?Tyr?Ser?Thr?Asp?Gly?Gly

35 40 45

gtc?act?tgg?acc?gag?cca?act?ctt?gat?acc?cag?ctg?ccg?gat?cct?cgc 192

Val?Thr?Trp?Thr?Glu?Pro?Thr?Leu?Asp?Thr?Gln?Leu?Pro?Asp?Pro?Arg

50 55 60

aac?aat?gct?tcc?ctg?att?cga?gta?ttc?ccg?aca?gca?cct?gag?gga?agt 240

Asn?Asn?Ala?Ser?Leu?Ile?Arg?Val?Phe?Pro?Thr?Ala?Pro?Glu?Gly?Ser

65 70 75 80

gcg?cag?gca?aag?gtt?ctg?ctg?ttc?tcc?aac?act?gcc?acc?acg?agt?ggc 288

Ala?Gln?Ala?Lys?Val?Leu?Leu?Phe?Ser?Asn?Thr?Ala?Thr?Thr?Ser?Gly

85 90 95

cgc?acc?aat?ggc?acc?gtc?cgc?atg?tcg?tgt?gat?gat?ggt?cag?acc?tgg 336

Arg?Thr?Asn?Gly?Thr?Val?Arg?Met?Ser?Cys?Asp?Asp?Gly?Gln?Thr?Trp

100 105 110

ccg?gtg?tct?aag?gtg?ttt?gaa?cca?gga?gca?atc?caa?tat?acc?tcg?atg 384

Pro?Val?Ser?Lys?Val?Phe?Glu?Pro?Gly?Ala?Ile?Gln?Tyr?Thr?Ser?Met

115 120 125

gca?acg?ctt?ccc?aac?ggt?gac?atc?ggc?atg?ctg?tgagaaaaca?gtggctcaaa 437

Ala?Thr?Leu?Pro?Asn?Gly?Asp?Ile?Gly?Met?Leu

130 135

tat 440

<210>236

<211>139

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>236

Gln?Arg?Gly?Thr?Pro?Val?Leu?Leu?Gly?Glu?Thr?Pro?Trp?Met?Lys?Thr

1 5 10 15

Lys?Ile?Val?Glu?Leu?Ser?Asp?Gly?Thr?Leu?Met?Asn?Asn?Ser?Arg?Ser

20 25 30

Ser?Gly?Ala?Asp?Thr?Tyr?Arg?Lys?Val?Ser?Tyr?Ser?Thr?Asp?Gly?Gly

35 40 45

Val?Thr?Trp?Thr?Glu?Pro?Thr?Leu?Asp?Thr?Gln?Leu?Pro?Asp?Pro?Arg

50 55 60

Asn?Asn?Ala?Ser?Leu?Ile?Arg?Val?Phe?Pro?Thr?Ala?Pro?Glu?Gly?Ser

65 70 75 80

Ala?Gln?Ala?Lys?Val?Leu?Leu?Phe?Ser?Asn?Thr?Ala?Thr?Thr?Ser?Gly

85 90 95

Arg?Thr?Asn?Gly?Thr?Val?Arg?Met?Ser?Cys?Asp?Asp?Gly?Gln?Thr?Trp

100 105 110

Pro?Val?Ser?Lys?Val?Phe?Glu?Pro?Gly?Ala?Ile?Gln?Tyr?Thr?Ser?Met

115 120 125

Ala?Thr?Leu?Pro?Asn?Gly?Asp?Ile?Gly?Met?Leu

130 135

<210>237

<211>832

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(832)

<223>RXN02513

<400>237

acagcaccgt?tttgtaggat?aagaaaatcc?cgcacacaac?ccgtcctggt?gggtgaagtg 60

ggggaggcat?gtctatgccc?ccaattagac?atctgacatc?atg?ctt?cca?atc?tgg 115

Met?Leu?Pro?Ile?Trp

1 5

atg?ggt?ctt?cca?ttc?aag?aaa?gca?ggt?gct?ttg?tct?cgg?cgt?aaa?gca 163

Met?Gly?Leu?Pro?Phe?Lys?Lys?Ala?Gly?Ala?Leu?Ser?Arg?Arg?Lys?Ala

10 15 20

gta?ttc?tca?gcg?ctt?ggt?gca?gcc?gca?ctc?atg?ggc?gca?gca?cta?ccc 211

Val?Phe?Ser?Ala?Leu?Gly?Ala?Ala?Ala?Leu?Met?Gly?Ala?Ala?Leu?Pro

25 30 35

acc?atc?cca?acg?gcc?caa?gct?caa?aca?ccc?acg?ggc?tac?gga?ttc?gat 259

Thr?Ile?Pro?Thr?Ala?Gln?Ala?Gln?Thr?Pro?Thr?Gly?Tyr?Gly?Phe?Asp

40 45 50

gca?aca?gca?agc?atc?agc?gaa?gaa?cca?gag?ttt?tca?aca?caa?caa?ctc 307

Ala?Thr?Ala?Ser?Ile?Ser?Glu?Glu?Pro?Glu?Phe?Ser?Thr?Gln?Gln?Leu

55 60 65

gct?gac?ggc?gga?act?ctc?gga?ttt?gat?tgc?tac?cgc?atc?cca?tcg?ctt 355

Ala?Asp?Gly?Gly?Thr?Leu?Gly?Phe?Asp?Cys?Tyr?Arg?Ile?Pro?Ser?Leu

70 75 80 85

ggc?gtc?gca?ccc?aac?ggc?aac?gtc?ctc?gca?tcg?tgg?gat?ggt?cgc?cca 403

Gly?Val?Ala?Pro?Asn?Gly?Asn?Val?Leu?Ala?Ser?Trp?Asp?Gly?Arg?Pro

90 95 100

aac?aac?tgt?tca?gat?gct?cca?caa?ccc?aac?tcc?arc?gtg?ggc?aag?gta 451

Asn?Asn?Cys?Ser?Asp?Ala?Pro?Gln?Pro?Asn?Ser?Ile?Val?Gly?Lys?Val

105 110 115

tcg?acc?gac?aac?gga?gca?acc?tgg?ggc?gaa?cag?cac?gac?att?tcc?gca 499

Ser?Thr?Asp?Asn?Gly?Ala?Thr?Trp?Gly?Glu?Gln?His?Asp?Ile?Ser?Ala

120 125 130

ggt?atc?acc?gcc?gaa?ccc?aaa?act?ggc?tat?tcc?gat?ccc?agc?atc?gtt 547

Gly?Ile?Thr?Ala?Glu?Pro?Lys?Thr?Gly?Tyr?Ser?Asp?Pro?Ser?Ile?Val

135 140 145

gtg?gac?tgg?gag?agg?ggc?gat?gtc?ttt?aac?ttc?cac?gtg?aag?tca?ttc 595

Val?Asp?Trp?Glu?Arg?Gly?Asp?Val?Phe?Asn?Phe?His?Val?Lys?Ser?Phe

150 155 160 165

gat?gca?gga?tac?ttc?acc?tcc?caa?cca?ggc?acg?gac?ccg?gat?gat?cgc 643

Asp?Ala?Gly?Tyr?Phe?Thr?Ser?Gln?Pro?Gly?Thr?Asp?Pro?Asp?Asp?Arg

170 175 180

aac?gtt?gcc?cat?gtt?gcc?tac?gcc?aaa?tca?tca?gat?aac?ggc?tca?acc 691

Asn?Val?Ala?His?Val?Ala?Tyr?Ala?Lys?Ser?Ser?Asp?Asn?Gly?Ser?Thr

185 190 195

tgg?gtt?gca?gac?acc?gtc?att?act?gat?caa?gtg?gtt?gct?cat?gac?acc 739

Trp?Val?Ala?Asp?Thr?Val?Ile?Thr?Asp?Gln?Val?Val?Ala?His?Asp?Thr

200 205 210

tgg?gac?agc?cga?ttt?gcc?aca?tcc?gga?aac?ggc?atc?caa?ctg?caa?tac 787

Trp?Asp?Ser?Arg?Phe?Ala?Thr?Ser?Gly?Asn?Gly?Ile?Gln?Leu?Gln?Tyr

215 220 225

ggc?gcg?tac?aag?gga?cga?ttg?gtc?cag?cca?tcg?gta?act?cgc?atg 832

Gly?Ala?Tyr?Lys?Gly?Arg?Leu?Val?Gln?Pro?Ser?Val?Thr?Arg?Met

230 235 240

<210>238

<211>244

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>238

Met?Leu?Pro?Ile?Trp?Met?Gly?Leu?Pro?Phe?Lys?Lys?Ala?Gly?Ala?Leu

1 5 10 15

Ser?Arg?Arg?Lys?Ala?Val?Phe?Ser?Ala?Leu?Gly?Ala?Ala?Ala?Leu?Met

20 25 30

Gly?Ala?Ala?Leu?Pro?Thr?Ile?Pro?Thr?Ala?Gln?Ala?Gln?Thr?Pro?Thr

35 40 45

Gly?Tyr?Gly?Phe?Asp?Ala?Thr?Ala?Ser?Ile?Ser?Glu?Glu?Pro?Glu?Phe

50 55 60

Ser?Thr?Gln?Gln?Leu?Ala?Asp?Gly?Gly?Thr?Leu?Gly?Phe?Asp?Cys?Tyr

65 70 75 80

Arg?Ile?Pro?Ser?Leu?Gly?Val?Ala?Pro?Asn?Gly?Asn?Val?Leu?Ala?Ser

85 90 95

Trp?Asp?Gly?Arg?Pro?Asn?Asn?Cys?Ser?Asp?Ala?Pro?Gln?Pro?Asn?Ser

100 105 110

Ile?Val?Gly?Lys?Val?Ser?Thr?Asp?Asn?Gly?Ala?Thr?Trp?Gly?Glu?Gln

115 120 125

His?Asp?Ile?Ser?Ala?Gly?Ile?Thr?Ala?Glu?Pro?Lys?Thr?Gly?Tyr?Ser

130 135 140

Asp?Pro?Ser?Ile?Val?Val?Asp?Trp?Glu?Arg?Gly?Asp?Val?Phe?Asn?Phe

145 150 155 160

His?Val?Lys?Ser?Phe?Asp?Ala?Gly?Tyr?Phe?Thr?Ser?Gln?Pro?Gly?Thr

165 170 175

Asp?Pro?Asp?Asp?Arg?Asn?Val?Ala?His?Val?Ala?Tyr?Ala?Lys?Ser?Ser

180 185 190

Asp?Asn?Gly?Ser?Thr?Trp?Val?Ala?Asp?Thr?Val?Ile?Thr?Asp?Gln?Val

195 200 205

Val?Ala?His?Asp?Thr?Trp?Asp?Ser?Arg?Phe?Ala?Thr?Ser?Gly?Asn?Gly

210 215 220

Ile?Gln?Leu?Gln?Tyr?Gly?Ala?Tyr?Lys?Gly?Arg?Leu?Val?Gln?Pro?Ser

225 230 235 240

Val?Thr?Arg?Met

<210>239

<211>824

<212>DNA

＜2l3〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(93)..(824)

<223>FRXA02513

<400>239

gtcatgtagg?ataagaaaat?cccgcacaca?acccgtcctg?gtggggtaag?tgagggaggc 60

atgtctatgc?ccccaattag?acatctgaca?tc?atg?ctt?cca?atc?tgg?atg?ggt 113

Met?Leu?Pro?Ile?Trp?Met?Gly

1 5

ctt?cca?ttc?aag?aaa?gca?ggg?gct?ttg?tct?cgg?cgt?aaa?gca?gta?ttc 161

Leu?Pro?Phe?Lys?Lys?Ala?Gly?Ala?Leu?Ser?Arg?Arg?Lys?Ala?Val?Phe

10 15 20

tca?gcg?ctt?ggt?gca?gac?gca?ctc?atg?ggc?gca?gca?cta?ccc?acc?atc 209

Ser?Ala?Leu?Gly?Ala?Asp?Ala?Leu?Met?Gly?Ala?Ala?Leu?Pro?Thr?Ile

25 30 35

cca?acg?gcc?caa?gct?caa?aca?ccc?acg?ggc?tac?gga?ttc?gat?gca?aca 257

Pro?Thr?Ala?Gln?Ala?Gln?Thr?Pro?Thr?Gly?Tyr?Gly?Phe?Asp?Ala?Thr

40 45 50 55

gca?agc?atc?agc?gaa?gaa?cca?gag?ttt?tca?aca?caa?caa?ctc?gct?gac 305

Ala?Ser?Ile?Ser?Glu?Glu?Pro?Glu?Phe?Ser?Thr?Gln?Gln?Leu?Ala?Asp

60 65 70

ggc?gga?act?ctc?gga?ttt?gat?tgc?tac?cgc?atc?cca?tcg?ctt?ggc?gtc 353

Gly?Gly?Thr?Leu?Gly?Phe?Asp?Cys?Tyr?Arg?Ile?Pro?Ser?Leu?Gly?Val

75 80 85

gca?ccc?aac?ggc?aac?gtc?ctc?gca?tcg?tgg?gat?ggt?cgc?cca?aac?aac 401

Ala?Pro?Asn?Gly?Asn?Val?Leu?Ala?Ser?Trp?Asp?Gly?Arg?Pro?Asn?Asn

90 95 100

tgt?tea?gat?get?cea?caa?ccc?aac?tcc?ate?gtg?ggc?aag?gta?tcg?acc 449

Cys?Ser?Asp?Ala?Pro?Gln?Pro?Asn?Ser?Ile?Val?Gly?Lys?Val?Ser?Thr

105 110 115

gac?aac?gga?gca?acc?tgg?ggc?gaa?cag?cac?gac?att?tcc?gca?ggt?atc 497

Asp?Asn?Gly?Ala?Thr?Trp?Gly?Glu?Gln?His?Asp?Ile?Ser?Ala?Gly?Ile

120 125 130 135

acc?gcc?gaa?ccc?aaa?act?ggc?tat?tcc?gat?ccc?agc?atc?gtt?gtg?gac 545

Thr?Ala?Glu?Pro?Lys?Thr?Gly?Tyr?Ser?Asp?Pro?Ser?Ile?Val?Val?Asp

140 145 150

tgg?gag?agg?ggc?gat?gtc?ttt?aac?ttc?cac?gtg?aag?tca?ttc?gat?gca 593

Trp?Glu?Arg?Gly?Asp?Val?Phe?Asn?Phe?His?Val?Lys?Ser?Phe?Asp?Ala

155 160 165

gga?tac?ttc?acc?tcc?caa?cca?ggc?acg?gac?ccg?gat?gat?cgc?aac?gtt 641

Gly?Tyr?Phe?Thr?Ser?Gln?Pro?Gly?Thr?Asp?Pro?Asp?Asp?Arg?Asn?Val

170 175 180

gcc?cat?gtt?gcc?tac?gcc?aaa?tca?tca?gat?aac?ggc?tca?acc?tgg?gtt 689

Ala?His?Val?Ala?Tyr?Ala?Lys?Ser?Ser?Asp?Asn?Gly?Ser?Thr?Trp?Val

185 190 195

gca?gac?acc?gtc?att?act?gat?caa?gtg?gtt?gct?cat?gac?acc?tgg?gac 737

Ala?Asp?Thr?Val?Ile?Thr?Asp?Gln?Val?Val?Ala?His?Asp?Thr?Trp?Asp

200 205 210 215

agc?cga?ttt?gcc?aca?tcc?gga?aac?ggc?atc?caa?ctg?caa?tac?ggc?gcg 785

Ser?Arg?Phe?Ala?Thr?Ser?Gly?Asn?Gly?Ile?Gln?Leu?Gln?Tyr?Gly?Ala

220 225 230

tac?aag?gga?cga?ttg?gtc?cag?cca?tcg?gta?act?cgc?atg 824

Tyr?Lys?Gly?Arg?Leu?Val?Gln?Pro?Ser?Val?Thr?Arg?Met

235 240

<210>240

<211>244

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>240

Met?Leu?Pro?Ile?Trp?Met?Gly?Leu?Pro?Phe?Lys?Lys?Ala?Gly?Ala?Leu

1 5 10 15

Ser?Arg?Arg?Lys?Ala?Val?Phe?Ser?Ala?Leu?Gly?Ala?Asp?Ala?Leu?Met

20 25 30

Gly?Ala?Ala?Leu?Pro?Thr?Ile?Pro?Thr?Ala?Gln?Ala?Gln?Thr?Pro?Thr

35 40 45

Gly?Tyr?Gly?Phe?Asp?Ala?Thr?Ala?Ser?Ile?Ser?Glu?Glu?Pro?Glu?Phe

50 55 60

Ser?Thr?Gln?Gln?Leu?Ala?Asp?Gly?Gly?Thr?Leu?Gly?Phe?Asp?Cys?Tyr

65 70 75 80

Arg?Ile?Pro?Ser?Leu?Gly?Val?Ala?Pro?Asn?Gly?Asn?Val?Leu?Ala?Ser

85 90 95

Trp?Asp?Gly?Arg?Pro?Asn?Asn?Cys?Ser?Asp?Ala?Pro?Gln?Pro?Asn?Ser

100 105 110

Ile?Val?Gly?Lys?Val?Ser?Thr?Asp?Asn?Gly?Ala?Thr?Trp?Gly?Glu?Gln

115 120 125

His?Asp?Ile?Ser?Ala?Gly?Ile?Thr?Ala?Glu?Pro?Lys?Thr?Gly?Tyr?Ser

130 135 140

Asp?Pro?Ser?Ile?Val?Val?Asp?Trp?Glu?Arg?Gly?Asp?Val?Phe?Asn?Phe

145 150 155 160

His?Val?Lys?Ser?Phe?Asp?Ala?Gly?Tyr?Phe?Thr?Ser?Gln?Pro?Gly?Thr

165 170 175

Asp?Pro?Asp?Asp?Arg?Asn?Val?Ala?His?Val?Ala?Tyr?Ala?Lys?Ser?Ser

180 185 190

Asp?Asn?Gly?Ser?Thr?Trp?Val?Ala?Asp?Thr?Val?Ile?Thr?Asp?Gln?Val

195 200 205

Val?Ala?His?Asp?Thr?Trp?Asp?Ser?Arg?Phe?Ala?Thr?Ser?Gly?Asn?Gly

210 215 220

Ile?Gln?Leu?Gln?Tyr?Gly?Ala?Tyr?Lys?Gly?Arg?Leu?Val?Gln?Pro?Ser

225 230 235 240

Val?Thr?Arg?Met

<210>241

<211>733

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(733)

<223>RXA00903

<400>241

gcactcggaa?tcgtcgtcct?agaaaagaaa?gacgcctaaa?atgccctcta?aaatatcgcg 60

gccctattac?caagtagatg?tattcagctc?cgagccgttc?atg?gga?aac?ccg?ctt 115

Met?Gly?Asn?Pro?Leu

1 5

gct?gtc?atc?gcc?gat?gct?gat?gac?tta?agt?gcc?gaa?caa?atg?gcc?cga 163

Ala?Val?Ile?Ala?Asp?Ala?Asp?Asp?Leu?Ser?Ala?Glu?Gln?Met?Ala?Arg

10 15 20

atc?gct?agg?tgg?aca?aac?ctc?tca?gaa?acc?aca?ttt?ctt?tta?aag?cca 211

Ile?Ala?Arg?Trp?Thr?Asn?Leu?Ser?Glu?Thr?Thr?Phe?Leu?Leu?Lys?Pro

25 30 35

acc?caa?gaa?ggt?gct?gac?tac?cgg?gta?cgc?att?ttc?acc?cca?acc?ggt 259

Thr?Gln?Glu?Gly?Ala?Asp?Tyr?Arg?Val?Arg?Ile?Phe?Thr?Pro?Thr?Gly

40 45 50

gag?ctc?ccc?ttc?gct?gga?cac?cca?aca?ctc?gga?acc?gcc?cac?gtg?ttt 307

Glu?Leu?Pro?Phe?Ala?Gly?His?Pro?Thr?Leu?Gly?Thr?Ala?His?Val?Phe

55 60 65

agg?gaa?ctg?cac?ggt?gaa?cag?gga?acc?cag?ttg?gtt?cag?gaa?tgt?gtc 355

Arg?Glu?Leu?His?Gly?Glu?Gln?Gly?Thr?Gln?Leu?Val?Gln?Glu?Cys?Val

70 75 80 85

gcc?ggt?tta?gtt?gct?gtg?cgc?gct?att?gac?ggg?cca?gca?agt?gga?ttg 403

Ala?Gly?Leu?Val?Ala?Val?Arg?Ala?Ile?Asp?Gly?Pro?Ala?Ser?Gly?Leu

90 95 100

gct?ttt?cag?gct?cca?ccc?aca?ctc?aaa?gac?ggg?cca?ttg?gat?gct?tcc 451

Ala?Phe?Gln?Ala?Pro?Pro?Thr?Leu?Lys?Asp?Gly?Pro?Leu?Asp?Ala?Ser

105 110 115

gac?cta?gac?gca?gct?tgt?gag?gct?tta?gga?atc?agc?ccc?gac?ttc?att 499

Asp?Leu?Asp?Ala?Ala?Cys?Glu?Ala?Leu?Gly?Ile?Ser?Pro?Asp?Phe?Ile

120 125 130

cga?gcc?cac?caa?tgg?gta?gac?aac?ggc?ccc?ggc?tgg?gca?gta?gtg?gag 547

Arg?Ala?His?Gln?Trp?Val?Asp?Asn?Gly?Pro?Gly?Trp?Ala?Val?Val?Glu

135 140 145

cta?ccg?agc?gcc?caa?cac?gta?ttg?gat?ctg?gaa?ccc?gat?ttc?agt?gca 595

Leu?Pro?Ser?Ala?Gln?His?Val?Leu?Asp?Leu?Glu?Pro?Asp?Phe?Ser?Ala

150 155 160 165

cat?cca?aca?ttg?aaa?ctc?gga?gtg?att?ggg?gcc?tat?ccc?gaa?ggg?gct 643

His?Pro?Thr?Leu?Lys?Leu?Gly?Val?Ile?Gly?Ala?Tyr?Pro?Glu?Gly?Ala

170 175 180

ccc?cac?gcc?ttt?gaa?gta?cgg?gca?ttc?gct?caa?gga?atc?ggt?gaa?gac 691

Pro?His?Ala?Phe?Glu?Val?Arg?Ala?Phe?Ala?Gln?Gly?Ile?Gly?Glu?Asp

185 190 195

cca?gtt?aca?gga?agc?ctc?aat?gca?ttc?att?gcg?cag?tgg?cta 733

Pro?Val?Thr?Gly?Ser?Leu?Asn?Ala?Phe?Ile?Ala?Gln?Trp?Leu

200 205 210

<210>242

<211>211

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>242

Met?Gly?Asn?Pro?Leu?Ala?Val?Ile?Ala?Asp?Ala?Asp?Asp?Leu?Ser?Ala

1 5 10 15

Glu?Gln?Met?Ala?Arg?Ile?Ala?Arg?Trp?Thr?Asn?Leu?Ser?Glu?Thr?Thr

20 25 30

Phe?Leu?Leu?Lys?Pro?Thr?Gln?Glu?Gly?Ala?Asp?Tyr?Arg?Val?Arg?Ile

35 40 45

Phe?Thr?Pro?Thr?Gly?Glu?Leu?Pro?Phe?Ala?Gly?His?Pro?Thr?Leu?Gly

50 55 60

Thr?Ala?His?Val?Phe?Arg?Glu?Leu?His?Gly?Glu?Gln?Gly?Thr?Gln?Leu

65 70 75 80

Val?Gln?Glu?Cys?Val?Ala?Gly?Leu?Val?Ala?Val?Arg?Ala?Ile?Asp?Gly

85 90 95

Pro?Ala?Ser?Gly?Leu?Ala?Phe?Gln?Ala?Pro?Pro?Thr?Leu?Lys?Asp?Gly

100 105 110

Pro?Leu?Asp?Ala?Ser?Asp?Leu?Asp?Ala?Ala?Cys?Glu?Ala?Leu?Gly?Ile

115 120 125

Ser?Pro?Asp?Phe?Ile?Arg?Ala?His?Gln?Trp?Val?Asp?Asn?Gly?Pro?Gly

130 135 140

Trp?Ala?Val?Val?Glu?Leu?Pro?Ser?Ala?Gln?His?Val?Leu?Asp?Leu?Glu

145 150 155 160

Pro?Asp?Phe?Ser?Ala?His?Pro?Thr?Leu?Lys?Leu?Gly?Val?Ile?Gly?Ala

165 170 175

Tyr?Pro?Glu?Gly?Ala?Pro?His?Ala?Phe?Glu?Val?Arg?Ala?Phe?Ala?Gln

180 185 190

Gly?Ile?Gly?Glu?Asp?Pro?Val?Thr?Gly?Ser?Leu?Asn?Ala?Phe?Ile?Ala

195 200 205

Gln?Trp?Leu

210

<210>243

<211>1146

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1123)

<223>RXA01224

<400>243

ttggcggcgg?gaagttcagg?cttgggggca?aacagtgctt?ggattttaga?caaaaaactc 60

acggaagtca?tcctatggca?ggcgcgccta?ggatggtgcc?atg?agc?atc?ctt?gac 115

Met?Ser?Ile?Leu?Asp

1 5

acg?ttg?aaa?act?ccc?gtg?att?gtc?gcc?ccg?atg?gct?ggc?ggc?ccg?tcc 163

Thr?Leu?Lys?Thr?Pro?Val?Ile?Val?Ala?Pro?Met?Ala?Gly?Gly?Pro?Ser

10 15 20

act?ccc?gcg?ttg?gtc?aat?gca?gca?gca?gag?gca?ggt?tcc?ctc?ggg?ttc 211

Thr?Pro?Ala?Leu?Val?Asn?Ala?Ala?Ala?Glu?Ala?Gly?Ser?Leu?Gly?Phe

25 30 35

ttg?gct?ggt?ggc?gtc?atg?cct?ctt?gag?cag?ctg?aaa?cag?gaa?ttg?tca 259

Leu?Ala?Gly?Gly?Val?Met?Pro?Leu?Glu?Gln?Leu?Lys?Gln?Glu?Leu?Ser

40 45 50

gag?gta?aaa?ggc?gtc?ttt?ggc?gtc?aac?ctg?ttt?cgc?ccg?cag?acg?gat 307

Glu?Val?Lys?Gly?Val?Phe?Gly?Val?Asn?Leu?Phe?Arg?Pro?Gln?Thr?Asp

55 60 65

gcg?cct?aag?cct?tca?gac?att?gat?gag?ctg?gcg?gga?ttg?ttg?tcc?tcg 355

Ala?Pro?Lys?Pro?Ser?Asp?Ile?Asp?Glu?Leu?Ala?Gly?Leu?Leu?Ser?Ser

70 75 80 85

gcg?ttt?cgg?caa?ttt?ggc?ctc?gat?gag?ccg?acg?gtg?cct?acg?ccg?gat 403

Ala?Phe?Arg?Gln?Phe?Gly?Leu?Asp?Glu?Pro?Thr?Val?Pro?Thr?Pro?Asp

90 95 100

ttg?agc?aat?ggg?tgg?gag?gct?aaa?ttt?gag?gcc?gtt?ctt?gcc?gct?aag 451

Leu?Ser?Asn?Gly?Trp?Glu?Ala?Lys?Phe?Glu?Ala?Val?Leu?Ala?Ala?Lys

105 110 115

ccc?gcc?gtt?ttt?tcc?tgc?acc?ttt?ggt?att?ttt?agc?gct?gaa?gaa?ttc 499

Pro?Ala?Val?Phe?Ser?Cys?Thr?Phe?Gly?Ile?Phe?Ser?Ala?Glu?Glu?Phe

120 125 130

gcc?cgg?atc?aaa?gcc?acc?gga?att?gag?gcg?tgg?gtg?acg?gtg?acc?aat 547

Ala?Arg?Ile?Lys?Ala?Thr?Gly?Ile?Glu?Ala?Trp?Val?Thr?Val?Thr?Asn

135 140 145

ccg?gag?gac?gcg?ctg?gct?gcg?cag?aaa?gct?ggc?gcc?aac?gcg?ctt?gtc 595

Pro?Glu?Asp?Ala?Leu?Ala?Ala?Gln?Lys?Ala?Gly?Ala?Asn?Ala?Leu?Val

150 155 160 165

gtg?caa?ggc?ccc?gag?gcg?ggt?ggg?cac?cgc?tct?acc?tgg?tcc?att?gaa 643

Val?Gln?Gly?Pro?Glu?Ala?Gly?Gly?His?Arg?Ser?Thr?Trp?Ser?Ile?Glu

170 175 180

gtg?gag?ccg?gac?gag?cgc?gac?ctg?aaa?acc?ctc?ctc?gca?gct?gtc?aaa 691

Val?Glu?Pro?Asp?Glu?Arg?Asp?Leu?Lys?Thr?Leu?Leu?Ala?Ala?Val?Lys

185 190 195

caa?gcg?ggc?gtt?tac?ctc?ccg?ctc?atc?gca?gcc?ggc?ggc?ctt?tca?acc 739

Gln?Ala?Gly?Val?Tyr?Leu?Pro?Leu?Ile?Ala?Ala?Gly?Gly?Leu?Ser?Thr

200 205 210

tcc?gca?gac?gtg?gca?gca?att?tta?gaa?gcc?ggc?gcc?agc?gct?gcc?tcc 787

Ser?Ala?Asp?Val?Ala?Ala?Ile?Leu?Glu?Ala?Gly?Ala?Ser?Ala?Ala?Ser

215 220 225

tgt?ggt?tcc?gcc?ttt?ttg?ctt?agc?gac?gaa?gcc?ggc?acc?agc?tca?ctt 835

Cys?Gly?Ser?Ala?Phe?Leu?Leu?Ser?Asp?Glu?Ala?Gly?Thr?Ser?Ser?Leu

230 235 240 245

aac?cgc?gag?atc?ttg?gac?gcc?gcc?cca?gca?ctt?ggt?ttg?gaa?tcg?gtg 883

Asn?Arg?Glu?Ile?Leu?Asp?Ala?Ala?Pro?Ala?Leu?Gly?Leu?Glu?Ser?Val

250 255 260

tca?tct?cgc?gca?ttt?tcg?ggc?cgt?tat?gcc?agg?gga?gtg?gaa?acc?agg 931

Ser?Ser?Arg?Ala?Phe?Ser?Gly?Arg?Tyr?Ala?Arg?Gly?Val?Glu?Thr?Arg

265 270 275

ttc?acc?cgt?tcg?aac?gag?ggg?tta?ccc?ccg?ttg?tac?cca?tac?ctc?aac 979

Phe?Thr?Arg?Ser?Asn?Glu?Gly?Leu?Pro?Pro?Leu?Tyr?Pro?Tyr?Leu?Asn

280 285 290

cca?atg?atc?aca?tct?tta?cgt?aag?gtg?gcg?gga?agt?gca?ggg?aac?tgg 1027

Pro?Met?Ile?Thr?Ser?Leu?Arg?Lys?Val?Ala?Gly?Ser?Ala?Gly?Asn?Trp

295 300 305

gat?tac?gcc?tac?tgc?ctg?gta?gga?gtc?ggc?ctg?gaa?tcg?att?gcg?aag 1075

Asp?Tyr?Ala?Tyr?Cys?Leu?Val?Gly?Val?Gly?Leu?Glu?Ser?Ile?Ala?Lys

310 315 320 325

ggt?agt?gca?aag?cag?ata?ctg?gaa?tca?tta?aca?cct?tcc?gct?ttg?ggc 1123

Gly?Ser?Ala?Lys?Gln?Ile?Leu?Glu?Ser?Leu?Thr?Pro?Ser?Ala?Leu?Gly

330 335 340

taatgttggg?gggagtgctt?tca 1146

<210>244

<211>341

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>244

Met?Ser?Ile?Leu?Asp?Thr?Leu?Lys?Thr?Pro?Val?Ile?Val?Ala?Pro?Met

1 5 10 15

Ala?Gly?Gly?Pro?Ser?Thr?Pro?Ala?Leu?Val?Asn?Ala?Ala?Ala?Glu?Ala

20 25 30

Gly?Ser?Leu?Gly?Phe?Leu?Ala?Gly?Gly?Val?Met?Pro?Leu?Glu?Gln?Leu

35 40 45

Lys?Gln?Glu?Leu?Ser?Glu?Val?Lys?Gly?Val?Phe?Gly?Val?Asn?Leu?Phe

50 55 60

Arg?Pro?Gln?Thr?Asp?Ala?Pro?Lys?Pro?Ser?Asp?Ile?Asp?Glu?Leu?Ala

65 70 75 80

Gly?Leu?Leu?Ser?Ser?Ala?Phe?Arg?Gln?Phe?Gly?Leu?Asp?Glu?Pro?Thr

85 90 95

Val?Pro?Thr?Pro?Asp?Leu?Ser?Asn?Gly?Trp?Glu?Ala?Lys?Phe?Glu?Ala

100 105 110

Val?Leu?Ala?Ala?Lys?Pro?Ala?Val?Phe?Ser?Cys?Thr?Phe?Gly?Ile?Phe

115 120 125

Ser?Ala?Glu?Glu?Phe?Ala?Arg?Ile?Lys?Ala?Thr?Gly?Ile?Glu?Ala?Trp

130 135 140

Val?Thr?Val?Thr?Asn?Pro?Glu?Asp?Ala?Leu?Ala?Ala?Gln?Lys?Ala?Gly

145 150 155 160

Ala?Asn?Ala?Leu?Val?Val?Gln?Gly?Pro?Glu?Ala?Gly?Gly?His?Arg?Ser

165 170 175

Thr?Trp?Ser?Ile?Glu?Val?Glu?Pro?Asp?Glu?Arg?Asp?Leu?Lys?Thr?Leu

180 185 190

Leu?Ala?Ala?Val?Lys?Gln?Ala?Gly?Val?Tyr?Leu?Pro?Leu?Ile?Ala?Ala

195 200 205

Gly?Gly?Leu?Ser?Thr?Ser?ala?Asp?Val?Ala?Ala?Ile?Leu?Glu?Ala?Gly

210 215 220

Ala?Ser?Ala?Ala?Ser?Cys?Gly?Ser?Ala?Phe?Leu?Leu?Ser?Asp?Glu?Ala

225 230 235 240

Gly?Thr?Ser?Ser?Leu?Asn?Arg?Glu?Ile?Leu?Asp?Ala?Ala?Pro?Ala?Leu

245 250 255

Gly?Leu?Glu?Ser?Val?Ser?Ser?Arg?Ala?Phe?Ser?Gly?Arg?Tyr?Ala?Arg

260 265 270

Gly?Val?Glu?Thr?Arg?Phe?Thr?Arg?Ser?Asn?Glu?Gly?Leu?Pro?Pro?Leu

275 280 285

Tyr?Pro?Tyr?Leu?Asn?Pro?Met?Ile?Thr?Ser?Leu?Arg?Lys?Val?Ala?Gly

290 295 300

Ser?Ala?Gly?Asn?Trp?Asp?Tyr?Ala?Tyr?Cys?Leu?Val?Gly?Val?Gly?Leu

305 310 315 320

Glu?Ser?Ile?Ala?Lys?Gly?Ser?Ala?Lys?Gln?Ile?Leu?Glu?Ser?Leu?Thr

325 330 335

Pro?Ser?Ala?Leu?Gly

340

<210>245

<211>723

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(700)

<223>RXA01571

<400>245

aaactacctg?ctgagagctt?tgtaatttac?ggtgtggttg?tggaggggtg?cgtcgagaag 60

cgctcgtagg?cgcttttgat?ttttcggtag?gctaactggg?gtg?agt?atc?tca?gta 115

Val?Ser?Ile?Ser?Val

1 5

aaa?gca?cta?caa?aag?tcc?ggc?cca?gaa?gca?cct?ttc?gag?gtc?aag?atc 163

Lys?Ala?Leu?Gln?Lys?Ser?Gly?Pro?Glu?Ala?Pro?Phe?Glu?Val?Lys?Ile

10 15 20

att?gaa?cgc?cgt?gac?cca?cgc?gca?gat?gat?gtg?gtt?att?gat?atc?aaa 211

Ile?Glu?Arg?Arg?Asp?Pro?Arg?Ala?Asp?Asp?Val?Val?Ile?Asp?Ile?Lys

25 30 35

gct?gcg?ggc?atc?tgc?cac?agc?gat?atc?cac?acc?atc?cgc?aac?gaa?tgg 259

Ala?Ala?Gly?Ile?Cys?His?Ser?Asp?Ile?His?Thr?Ile?Arg?Asn?Glu?Trp

40 45 50

ggc?gag?gcg?cac?ttc?ccg?ctc?acc?gtc?ggc?cac?gaa?atc?gca?ggc?gtt 307

Gly?Glu?Ala?His?Phe?Pro?Leu?Thr?Val?Gly?His?Glu?Ile?Ala?Gly?Val

55 60 65

gtc?tct?gcg?gtt?gga?tcc?gat?gta?acc?aaa?tgg?aaa?gtc?ggc?gac?cgc 355

Val?Ser?Ala?Val?Gly?Ser?Asp?Val?Thr?Lys?Trp?Lys?Val?Gly?Asp?Arg

70 75 80 85

gtg?ggc?gtc?ggc?tgc?ctc?gtt?aac?tcc?tgc?ggc?gaa?tgc?gaa?cag?tgc 403

Val?Gly?Val?Gly?Cys?Leu?Val?Asn?Ser?Cys?Gly?Glu?Cys?Glu?Gln?Cys

90 95 100

gtc?gca?gga?ttt?gaa?aac?aac?tgc?ctt?cgc?gga?aac?gtc?gga?acc?tac 451

Val?Ala?Gly?Phe?Glu?Asn?Asn?Cys?Leu?Arg?Gly?Asn?Val?Gly?Thr?Tyr

105 110 115

aac?tct?aac?gac?gtc?gac?ggc?acc?atc?acc?caa?ggc?ggc?tac?gct?gaa 499

Asn?Ser?Asn?Asp?Val?Asp?Gly?Thr?Ile?Thr?Gln?Gly?Gly?Tyr?Ala?Glu

120 125 130

aag?gta?gtg?gtc?aac?gaa?cgt?ttc?ctg?tgc?agc?atc?cca?gag?gaa?ctt 547

Lys?Val?Val?Val?Asn?Glu?Arg?Phe?Leu?Cys?Ser?Ile?Pro?Glu?Glu?Leu

135 140 145

aac?ttc?gat?gtc?gca?gca?cca?ctg?ctg?tgc?gca?ggc?atc?acc?acc?tac 595

Asn?Phe?Asp?Val?Ala?Ala?Pro?Leu?Leu?Cys?Ala?Gly?Ile?Thr?Thr?Tyr

150 155 160 165

tcc?cca?atc?gct?cgc?tgg?aac?gtt?aaa?gaa?ggc?gac?aaa?gta?gca?gtc 643

Ser?Pro?Ile?Ala?Arg?Trp?Asn?Val?Lys?Glu?Gly?Asp?Lys?Val?Ala?Val

170 175 180

atg?ggc?ctc?ggc?ggg?act?cgg?aca?cat?ggg?tgt?cca?gat?cgc?tgc?agc 691

Met?Gly?Leu?Gly?Gly?Thr?Arg?Thr?His?Gly?Cys?Pro?Asp?Arg?Cys?Ser

185 190 195

caa?ggg?tgc?tgaggttacc?gttctgtccc?gtt 723

Gln?Gly?Cys

200

<210>246

<211>200

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>246

Val?Ser?Ile?Ser?Val?Lys?Ala?Leu?Gln?Lys?Ser?Gly?Pro?Glu?Ala?Pro

1 5 10 15

Phe?Glu?Val?Lys?Ile?Ile?Glu?Arg?Arg?Asp?Pro?Arg?Ala?Asp?Asp?Val

20 25 30

Val?Ile?Asp?Ile?Lys?Ala?Ala?Gly?Ile?Cys?His?Ser?Asp?Ile?His?Thr

35 40 45

Ile?Arg?Asn?Glu?Trp?Gly?Glu?Ala?His?Phe?Pro?Leu?Thr?Val?Gly?His

50 55 60

Glu?Ile?Ala?Gly?Val?Val?Ser?Ala?Val?Gly?Ser?Asp?Val?Thr?Lys?Trp

65 70 75 80

Lys?Val?Gly?Asp?Arg?Val?Gly?Val?Gly?Cys?Leu?Val?Asn?Ser?Cys?Gly

85 90 95

Glu?Cys?Glu?Gln?Cys?Val?Ala?Gly?Phe?Glu?Asn?Asn?Cys?Leu?Arg?Gly

100 105 110

Asn?Val?Gly?Thr?Tyr?Asn?Ser?Asn?Asp?Val?Asp?Gly?Thr?Ile?Thr?Gln

115 120 125

Gly?Gly?Tyr?Ala?Glu?Lys?Val?Val?Val?Asn?Glu?Arg?Phe?Leu?Cys?Ser

130 135 140

Ile?Pro?Glu?Glu?Leu?Asn?Phe?Asp?Val?Ala?Ala?Pro?Leu?Leu?Cys?Ala

145 150 155 160

Gly?Ile?Thr?Thr?Tyr?Ser?Pro?Ile?Ala?Arg?Trp?Asn?Val?Lys?Glu?Gly

165 170 175

Asp?Lys?Val?Ala?Val?Met?Gly?Leu?Gly?Gly?Thr?Arg?Thr?His?Gly?Cys

180 185 190

Pro?Asp?Arg?Cys?Ser?Gln?Gly?Cys

195 200

<210>247

<211>1338

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1315)

<223>RXN02478

<400>247

gacatcgtcg?aagcgctctc?cagcggcaac?atcgacgatt?atcgcagcgc?cgtgctcgct 60

cactacgcgc?cgtttcgccg?catgatttcc?aacatgctcg?atg?cgc?act?agc?ctc 115

Met?Arg?Thr?Ser?Leu

1 5

att?gcg?cgc?ggg?ttg?tac?cgc?att?ccc?gcg?ctg?gtc?tgg?gat?cag?ggt 163

Ile?Ala?Arg?Gly?Leu?Tyr?Arg?Ile?Pro?Ala?Leu?Val?Trp?Asp?Gln?Gly

10 15 20

ctt?tta?acg?ctt?ttc?gac?gcc?cgc?ctc?agt?gtt?gac?gac?ctc?ccc?gca 211

Leu?Leu?Thr?Leu?Phe?Asp?Ala?Arg?Leu?Ser?Val?Asp?Asp?Leu?Pro?Ala

25 30 35

ccc?atc?gac?gtg?gtg?tca?gcg?cga?tcc?tca?gac?ggc?atc?acc?tgg?acc 259

Pro?Ile?Asp?Val?Val?Ser?Ala?Arg?Ser?Ser?Asp?Gly?Ile?Thr?Trp?Thr

40 45 50

acc?cca?gaa?cca?gca?atc?gtc?gaa?act?gaa?cac?cgc?ggt?gtg?ggc?gat 307

Thr?Pro?Glu?Pro?Ala?Ile?Val?Glu?Thr?Glu?His?Arg?Gly?Val?Gly?Asp

55 60 65

gtc?tgc?ctt?gtc?acg?ggc?gat?ctg?tgc?ttc?cac?gga?ttg?tcc?aac?ctc 355

Val?Cys?Leu?Val?Thr?Gly?Asp?Leu?Cys?Phe?His?Gly?Leu?Ser?Asn?Leu

70 75 80 85

gca?gga?ttt?ttt?gag?gat?ccc?acc?gac?ctt?gaa?ccc?cgg?ctg?gcg?cgc 403

Ala?Gly?Phe?Phe?Glu?Asp?Pro?Thr?Asp?Leu?Glu?Pro?Arg?Leu?Ala?Arg

90 95 100

cgg?gat?gtg?agt?ggg?tgg?acg?tcg?ata?agc?atg?gcc?cac?tat?ttt?gcg 451

Arg?Asp?Val?Ser?Gly?Trp?Thr?Ser?Ile?Ser?Met?Ala?His?Tyr?Phe?Ala

105 110 115

gat?gtt?gat?gcc?gcg?ttc?gcc?tcg?tcg?ggg?acg?gga?ctt?gtc?ctg?gcg 499

Asp?Val?Asp?Ala?Ala?Phe?Ala?Ser?Ser?Gly?Thr?Gly?Leu?Val?Leu?Ala

120 125 130

gat?ggg?cgg?tgg?att?cag?agt?ttt?gtg?gtg?cgg?cgc?ggg?cgc?gag?att 547

Asp?Gly?Arg?Trp?Ile?Gln?Ser?Phe?Val?Val?Arg?Arg?Gly?Arg?Glu?Ile

135 140 145

tcg?ctt?cgg?att?ctg?cgc?agc?gat?ggc?cac?atc?acc?gat?att?gcc?ggc 595

Ser?Leu?Arg?Ile?Leu?Arg?Ser?Asp?Gly?His?Ile?Thr?Asp?Ile?Ala?Gly

150 155 160 165

ggt?aac?gaa?tcc?gcg?atg?acg?cag?ctg?ccg?agc?ggt?cgg?att?gtg?ctg 643

Gly?Asn?Glu?Ser?Ala?Met?Thr?Gln?Leu?Pro?Ser?Gly?Arg?Ile?Val?Leu

170 175 180

cat?tcc?agg?ggg?gtg?gga?cac?cgt?ctg?agc?agt?gtg?tcc?gat?gat?ttc 691

His?Ser?Arg?Gly?Val?Gly?His?Arg?Leu?Ser?Ser?Val?Ser?Asp?Asp?Phe

185 190 195

ggg?gag?aca?ttc?act?ccg?ctg?gag?cct?gtg?cct?gaa?cta?atc?gac?ccc 739

Gly?Glu?Thr?Phe?Thr?Pro?Leu?Glu?Pro?Val?Pro?Glu?Leu?Ile?Asp?Pro

200 205 210

ggc?tgc?aac?ggc?cac?gtg?ttc?tac?tgg?aaa?gcg?gct?gga?atg?ctc?gcc 787

Gly?Cys?Asn?Gly?His?Val?Phe?Tyr?Trp?Lys?Ala?Ala?Gly?Met?Leu?Ala

215 220 225

gca?acg?cac?ctg?gcg?gac?cct?gat?ctg?cga?cgc?cac?ttg?gtg?gtt?gat 835

Ala?Thr?His?Leu?Ala?Asp?Pro?Asp?Leu?Arg?Arg?His?Leu?Val?Val?Asp

230 235 240 245

tta?tcc?agc?gac?gaa?gga?gcg?acc?tgg?gcg?cat?cgc?atc?acc?atc?gag 883

Leu?Ser?Ser?Asp?Glu?Gly?Ala?Thr?Trp?Ala?His?Arg?Ile?Thr?Ile?Glu

250 255 260

cgc?gaa?gaa?gcc?gcc?tat?tca?acc?gct?gcg?gaa?atg?ccc?aac?gga?gat 931

Arg?Glu?Glu?Ala?Ala?Tyr?Ser?Thr?Ala?Ala?Glu?Met?Pro?Asn?Gly?Asp

265 270 275

gtt?gcc?gtg?gtg?tgg?gaa?gca?gag?gga?acg?cgc?gcg?ata?aaa?tgc?acg 979

Val?Ala?Val?Val?Trp?Glu?Ala?Glu?Gly?Thr?Arg?Ala?Ile?Lys?Cys?Thr

280 285 290

gtg?atc?agc?gta?aat?gat?att?tcg?ctg?cgg?atc?gat?gag?ccc?att?tcc 1027

Val?Ile?Ser?Val?Asn?Asp?Ile?Ser?Leu?Arg?Ile?Asp?Glu?Pro?Ile?Ser

295 300 305

gat?gcc?ata?tcc?ctc?cgc?cat?gtg?gtg?atc?aac?gat?gac?cat?gac?ggc 1075

Asp?Ala?Ile?Ser?Leu?Arg?His?Val?Val?Ile?Asn?Asp?Asp?His?Asp?Gly

310 315 320 325

atc?gaa?gtc?gca?ctg?cct?gac?gca?tcg?caa?tgg?ggt?gaa?ggt?gta?ttc 1123

Ile?Glu?Val?Ala?Leu?Pro?Asp?Ala?Ser?Gln?Trp?Gly?Glu?Gly?Val?Phe

330 335 340

aaa?att?gtg?tcc?aat?cca?gac?gcg?agc?acc?caa?aaa?atc?cgc?act?cga 1171

Lys?Ile?Val?Ser?Asn?Pro?Asp?Ala?Ser?Thr?Gln?Lys?Ile?Arg?Thr?Arg

345 350 355

ggc?aag?ccc?gcg?cga?cag?acc?ctg?gaa?att?ggg?gat?gaa?ttg?gtt?ttt 1219

Gly?Lys?Pro?Ala?Arg?Gln?Thr?Leu?Glu?Ile?Gly?Asp?Glu?Leu?Val?Phe

360 365 370

gat?atc?cgc?aag?ggt?gga?gaa?gtg?gct?tac?ggc?gtc?acg?gtt?cct?tat 1267

Asp?Ile?Arg?Lys?Gly?Gly?Glu?Val?Ala?Tyr?Gly?Val?Thr?Val?Pro?Tyr

375 380 385

gat?ggt?cgc?tcg?ttg?ggg?gaa?gtt?aaa?cag?gat?ttt?gga?gtg?ggg?ctg 1315

Asp?Gly?Arg?Ser?Leu?Gly?Glu?Val?Lys?Gln?Asp?Phe?Gly?Val?Gly?Leu

390 395 400 405

tagaggccga?tttgcggtcc?ttt 1338

<210>248

<211>405

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>248

Met?Arg?Thr?Ser?Leu?Ile?Ala?Arg?Gly?Leu?Tyr?Arg?Ile?Pro?Ala?Leu

1 5 10 15

Val?Trp?Asp?Gln?Gly?Leu?Leu?Thr?Leu?Phe?Asp?Ala?Arg?Leu?Ser?Val

20 25 30

Asp?Asp?Leu?Pro?Ala?Pro?Ile?Asp?Val?Val?Ser?Ala?Arg?Ser?Ser?Asp

35 40 45

Gly?Ile?Thr?Trp?Thr?Thr?Pro?Glu?Pro?Ala?Ile?Val?Glu?Thr?Glu?His

50 55 60

Arg?Gly?Val?Gly?Asp?Val?Cys?Leu?Val?Thr?Gly?Asp?Leu?Cys?Phe?His

65 70 75 80

Gly?Leu?Ser?Asn?Leu?Ala?Gly?Phe?Phe?Glu?Asp?Pro?Thr?Asp?Leu?Glu

85 90 95

Pro?Arg?Leu?Ala?Arg?Arg?Asp?Val?Ser?Gly?Trp?Thr?Ser?Ile?Ser?Met

100 105 110

Ala?His?Tyr?Phe?Ala?Asp?Val?Asp?Ala?Ala?Phe?Ala?Ser?Ser?Gly?Thr

115 120 125

Gly?Leu?Val?Leu?Ala?Asp?Gly?Arg?Trp?Ile?Gln?Ser?Phe?Val?Val?Arg

130 135 140

Arg?Gly?Arg?Glu?Ile?Ser?Leu?Arg?Ile?Leu?Arg?Ser?Asp?Gly?His?Ile

145 150 155 160

Thr?Asp?Ile?Ala?Gly?Gly?Asn?Glu?Ser?Ala?Met?Thr?Gln?Leu?Pro?Ser

165 170 175

Gly?Arg?Ile?Val?Leu?His?Ser?Arg?Gly?Val?Gly?His?Arg?Leu?Ser?Ser

180 185 190

Val?Ser?Asp?Asp?Phe?Gly?Glu?Thr?Phe?Thr?Pro?Leu?Glu?Pro?Val?Pro

195 200 205

Glu?Leu?Ile?Asp?Pro?Gly?Cys?Asn?Gly?His?Val?Phe?Tyr?Trp?Lys?Ala

210 215 220

Ala?Gly?Met?Leu?Ala?Ala?Thr?His?Leu?Ala?Asp?Pro?Asp?Leu?Arg?Arg

225 230 235 240

His?Leu?Val?Val?Asp?Leu?Ser?Ser?Asp?Glu?Gly?Ala?Thr?Trp?Ala?His

245 250 255

Arg?Ile?Thr?Ile?Glu?Arg?Glu?Glu?Ala?Ala?Tyr?Ser?Thr?Ala?Ala?Glu

260 265 270

Met?Pro?Asn?Gly?Asp?Val?Ala?Val?Val?Trp?Glu?Ala?Glu?Gly?Thr?Arg

275 280 285

Ala?Ile?Lys?Cys?Thr?Val?Ile?Ser?Val?Asn?Asp?Ile?Ser?Leu?Arg?Ile

290 295 300

Asp?Glu?Pro?Ile?Ser?Asp?Ala?Ile?Ser?Leu?Arg?His?Val?Val?Ile?Asn

305 310 315 320

Asp?Asp?His?Asp?Gly?Ile?Glu?Val?Ala?Leu?Pro?Asp?Ala?Ser?Gln?Trp

325 330 335

Gly?Glu?Gly?Val?Phe?Lys?Ile?Val?Ser?Asn?Pro?Asp?Ala?Ser?Thr?Gln

340 345 350

Lys?Ile?Arg?Thr?Arg?Gly?Lys?Pro?Ala?Arg?Gln?Thr?Leu?Glu?Ile?Gly

355 360 365

Asp?Glu?Leu?Val?Phe?Asp?Ile?Arg?Lys?Gly?Gly?Glu?Val?Ala?Tyr?Gly

370 375 380

Val?Thr?Val?Pro?Tyr?Asp?Gly?Arg?Ser?Leu?Gly?Glu?Val?Lys?Gln?Asp

385 390 395 400

Phe?Gly?Val?Gly?Leu

405

<210>249

<211>1213

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1213)

<223>RXN00343

<400>249

ttcggtagaa?tgggtaggtt?gtcgtgcttg?aggtgtggtg?gataaccacc?tctacaacac 60

cacccaagct?ctgttagaaa?aaattgagga?agcagtctaa?atg?aaa?cac?caa?tat 115

Met?Lys?His?Gln?Tyr

1 5

gat?gtc?atc?gtt?gtc?ggt?tcc?ggc?gct?ggc?gga?tta?tca?gct?gca?gtc 163

Asp?Val?Ile?Val?Val?Gly?Ser?Gly?Ala?Gly?Gly?Leu?Ser?Ala?Ala?Val

10 15 20

agt?gca?gct?tac?ggc?ggt?aag?aaa?gtc?gct?gta?att?gaa?aag?gcc?tca 211

Ser?Ala?Ala?Tyr?Gly?Gly?Lys?Lys?Val?Ala?Val?Ile?Glu?Lys?Ala?Ser

25 30 35

gta?ctc?ggt?gga?gcc?acc?acc?tgg?tcc?ggc?ggt?tgg?gct?tgg?act?cct 259

Val?Leu?Gly?Gly?Ala?Thr?Thr?Trp?Ser?Gly?Gly?Trp?Ala?Trp?Thr?Pro

40 45 50

gga?acc?agc?ctt?gcg?cgc?aaa?gac?gga?gta?gtg?gaa?tcc?aaa?gaa?gaa 307

Gly?Thr?Ser?Leu?Ala?Arg?Lys?Asp?Gly?Val?Val?Glu?Ser?Lys?Glu?Glu

55 60 65

ttc?caa?acc?tac?ctg?caa?gcg?gta?gtg?ggg?gag?tac?tac?caa?gaa?gac 355

Phe?Gln?Thr?Tyr?Leu?Gln?Ala?Val?Val?Gly?Glu?Tyr?Tyr?Gln?Glu?Asp

70 75 80 85

aac?atc?tcc?gcc?ttc?ttg?gac?gca?gcc?cct?gaa?atg?gtc?gat?ttc?ttt 403

Asn?Ile?Ser?Ala?Phe?Leu?Asp?Ala?Ala?Pro?Glu?Met?Val?Asp?Phe?Phe

90 95 100

gaa?aaa?aac?acc?gac?ctg?cag?tgg?acc?ccc?ggc?gcg?aaa?atc?aac?gac 451

Glu?Lys?Asn?Thr?Asp?Leu?Gln?Trp?Thr?Pro?Gly?Ala?Lys?Ile?Asn?Asp

105 110 115

atc?tac?ggc?aac?ctc?ccc?ggt?gct?ggc?act?gga?cac?cgc?tcc?gtt?ggg 499

Ile?Tyr?Gly?Asn?Leu?Pro?Gly?Ala?Gly?Thr?Gly?His?Arg?Ser?Val?Gly

120 125 130

cca?aaa?cca?ttc?aac?gga?cgc?aaa?gta?ccc?aag?agt?gtt?ctt?cca?aaa 547

Pro?Lys?Pro?Phe?Asn?Gly?Arg?Lys?Val?Pro?Lys?Ser?Val?Leu?Pro?Lys

135 140 145

ctg?cgc?cac?cag?ctg?tat?gaa?acc?tcc?ttc?ctg?gga?atg?ggc?atc?atg 595

Leu?Arg?His?Gln?Leu?Tyr?Glu?Thr?Ser?Phe?Leu?Gly?Met?Gly?Ile?Met

15 155 160 165

gct?ggg?cct?gac?ctg?acg?aaa?ttc?ctc?tct?gct?tca?cag?ttc?gat?cca 643

Ala?Gly?Pro?Asp?Leu?Thr?Lys?Phe?Leu?Ser?Ala?Ser?Gln?Phe?Asp?Pro

170 175 180

cgt?ggt?tgg?gta?cat?gcc?gcc?agg?cgc?gtc?atc?gtg?cac?atg?tgg?gac 691

Arg?Gly?Trp?Val?His?Ala?Ala?Arg?Arg?Val?Ile?Val?His?Met?Trp?Asp

185 190 195

atg?gtc?gtg?cac?aaa?cgc?aat?atg?cag?atg?gtc?aac?ggt?gca?gca?ctc 739

Met?Val?Val?His?Lys?Arg?Asn?Met?Gln?Met?Val?Asn?Gly?Ala?Ala?Leu

200 205 210

acc?gct?cga?ctg?gct?acc?tct?gca?gac?aag?ctg?ggc?gtt?gat?ctc?ctg 787

Thr?Ala?Arg?Leu?Ala?Thr?Ser?Ala?Asp?Lys?Leu?Gly?Val?Asp?Leu?Leu

215 220 225

gtc?aat?cac?tcc?gca?gtg?tcg?ttg?aat?tac?aaa?aac?gac?cgc?gtt?acc 835

Val?Asn?His?Ser?Ala?Val?Ser?Leu?Asn?Tyr?Lys?Asn?Asp?Arg?Val?Thr

230 235 240 245

ggc?gtg?aaa?gta?caa?acc?cca?cag?ggc?ttg?gta?gat?ttc?gaa?gcc?act 883

Gly?Val?Lys?Val?Gln?Thr?Pro?Gln?Gly?Leu?Val?Asp?Phe?Glu?Ala?Thr

250 255 260

gcc?ggc?gtc?gtg?ctc?gcc?act?ggt?gga?ttc?ccc?aac?aac?gtt?gac?ctg 931

Ala?Gly?Val?Val?Leu?Ala?Thr?Gly?Gly?Phe?Pro?Asn?Asn?Val?Asp?Leu

265 270 275

cgc?aag?gaa?ctc?ttc?cca?cgc?acc?cca?tca?ggt?caa?gaa?cac?tgg?acc 979

Arg?Lys?Glu?Leu?Phe?Pro?Arg?Thr?Pro?Ser?Gly?Gln?Glu?His?Trp?Thr

280 285 290

ctc?gcg?cca?gca?gaa?acc?acc?ggc?gac?gga?cta?tcc?atg?gct?cgg?gaa 1027

Leu?Ala?Pro?Ala?Glu?Thr?Thr?Gly?Asp?Gly?Leu?Ser?Met?Ala?Arg?Glu

295 300 305

atc?ggt?gca?ggt?ttt?gtc?aac?gac?ctg?aaa?tcc?cca?gca?gca?tgg?tgc 1075

Ile?Gly?Ala?Gly?Phe?Val?Asn?Asp?Leu?Lys?Ser?Pro?Ala?Ala?Trp?Cys

310 315 320 325

cct?gtt?tca?ttg?gtc?cca?tac?ttc?aac?gga?aaa?gtc?ggc?acc?ttc?ccc 1123

Pro?Val?Ser?Leu?Val?Pro?Tyr?Phe?Asn?Gly?Lys?Val?Gly?Thr?Phe?Pro

330 335 340

cac?atc?atg?gac?cgc?gca?aaa?cca?ggc?tcc?atc?ggt?gtt?gtc?tcc?aca 1171

His?Ile?Met?Asp?Arg?Ala?Lys?Pro?Gly?Ser?Ile?Gly?Val?Val?Ser?Thr

345 350 355

ggt?aag?cga?ttc?gtc?aat?gaa?gcc?aac?ggc?tac?tac?gac?tac 1213

Gly?Lys?Arg?Phe?Val?Asn?Glu?Ala?Asn?Gly?Tyr?Tyr?Asp?Tyr

360 365 370

<210>250

<211>371

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>250

Met?Lys?His?Gln?Tyr?Asp?Val?Ile?Val?Val?Gly?Ser?Gly?Ala?Gly?Gly

1 5 10 15

Leu?Ser?Ala?Ala?Val?Ser?Ala?Ala?Tyr?Gly?Gly?Lys?Lys?Val?Ala?Val

20 25 30

Ile?Glu?Lys?Ala?Ser?Val?Leu?Gly?Gly?Ala?Thr?Thr?Trp?Ser?Gly?Gly

35 40 45

Trp?Ala?Trp?Thr?Pro?Gly?Thr?Ser?Leu?Ala?Arg?Lys?Asp?Gly?Val?Val

50 55 60

Glu?Ser?Lys?Glu?Glu?Phe?Gln?Thr?Tyr?Leu?Gln?Ala?Val?Val?Gly?Glu

65 70 75 80

Tyr?Tyr?Gln?Glu?Asp?Asn?Ile?Ser?Ala?Phe?Leu?Asp?Ala?Ala?Pro?Glu

85 90 95

Met?Val?Asp?Phe?Phe?Glu?Lys?ASn?Thr?Asp?Leu?Gln?Trp?Thr?Pro?Gly

100 105 110

Ala?Lys?Ile?Asn?Asp?Ile?Tyr?Gly?Asn?Leu?Pro?Gly?Ala?Gly?Thr?Gly

115 120 125

His?Arg?Ser?Val?Gly?Pro?Lys?Pro?Phe?Asn?Gly?Arg?Lys?Val?Pro?Lys

130 135 140

Ser?Val?Leu?Pro?Lys?Leu?Arg?His?Gln?Leu?Tyr?Glu?Thr?Ser?Phe?Leu

145 150 155 160

Gly?Met?Gly?Ile?Met?Ala?Gly?Pro?Asp?Leu?Thr?Lys?Phe?Leu?Ser?Ala

165 170 175

Ser?Gln?Phe?Asp?Pro?Arg?Gly?Trp?Val?His?Ala?Ala?Arg?Arg?Val?Ile

180 185 190

Val?His?Met?Trp?Asp?Met?Val?Val?His?Lys?Arg?Asn?Met?Gln?Met?Val

195 200 205

Asn?Gly?Ala?Ala?Leu?Thr?Ala?Arg?Leu?Ala?Thr?Ser?Ala?Asp?Lys?Leu

210 215 220

Gly?Val?Asp?Leu?Leu?Val?Asn?His?Ser?Ala?Val?Ser?Leu?Asn?Tyr?Lys

225 230 235 240

Asn?Asp?Arg?Val?Thr?Gly?Val?Lys?Val?Gln?Thr?Pro?Gln?Gly?Leu?Val

245 250 255

Asp?Phe?Glu?Ala?Thr?Ala?Gly?Val?Val?Leu?Ala?Thr?Gly?Gly?Phe?Pro

260 265 270

Asn?Asn?Val?Asp?Leu?Arg?Lys?Glu?Leu?Phe?Pro?Arg?Thr?Pro?Ser?Gly

275 280 285

Gln?Glu?His?Trp?Thr?Leu?Ala?Pro?Ala?Glu?Thr?Thr?Gly?Asp?Gly?Leu

290 295 300

Ser?Met?Ala?Arg?Glu?Ile?Gly?Ala?Gly?Phe?Val?Asn?Asp?Leu?Lys?Ser

305 310 315 320

Pro?Ala?Ala?Trp?Cys?Pro?Val?Ser?Leu?Val?Pro?Tyr?Phe?Asn?Gly?Lys

325 330 335

Val?Gly?Thr?Phe?Pro?His?Ile?Met?Asp?Arg?Ala?Lys?Pro?Gly?Ser?Ile

340 345 350

Gly?Val?Val?Ser?Thr?Gly?Lys?Arg?Phe?Val?Asn?Glu?Ala?Asn?Gly?Tyr

355 360 365

Tyr?Asp?Tyr

370

<210>251

<211>1083

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1060)

<223>RXN01555

<400>251

ctggttttgt?gccgaggatc?agccagcaag?ttaatgatcc?ttacatggcg?ctgttgttgg 60

cgcggtagtc?aatcatgggg?gagtatccca?ccgtatccgc?gtg?aac?aag?ggc?gtg 115

Val?Asn?Lys?Gly?Val

1 5

gtg?ctg?gta?gca?ggt?gga?ttc?tcc?cag?aat?cca?gaa?ctg?cgc?atg?aag 163

Val?Leu?Val?Ala?Gly?Gly?Phe?Ser?Gln?Asn?Pro?Glu?Leu?Arg?Met?Lys

10 15 20

tac?atg?cca?gaa?ccc?acc?cca?cag?ttc?tcc?cgc?acc?aac?gaa?agc?gcc 211

Tyr?Met?Pro?Glu?Pro?Thr?Pro?Gln?Phe?Ser?Arg?Thr?Asn?Glu?Ser?Ala

25 30 35

acc?ggc?gac?acc?atg?gcc?ctt?gct?gcg?aaa?gtg?gga?gca?cgc?cta?ggc 259

Thr?Gly?Asp?Thr?Met?Ala?Leu?Ala?Ala?Lys?Val?Gly?Ala?Arg?Leu?Gly

40 45 50

gac?gac?aac?ggt?gaa?aac?gca?ctg?tgg?ttc?cca?tcg?tcc?atc?ggc?acc 307

Asp?Asp?Asn?Gly?Glu?Asn?Ala?Leu?Trp?Phe?Pro?Ser?Ser?Ile?Gly?Thr

55 60 65

cgc?gcc?gac?gga?tcc?acc?gcg?gtg?tac?cca?cac?att?tgg?gac?cgt?ggc 355

Arg?Ala?Asp?Gly?Ser?Thr?Ala?Val?Tyr?Pro?His?Ile?Trp?Asp?Arg?Gly

70 75 80 85

cgc?ctc?gga?gtc?atc?gca?gtc?aac?gca?gca?ggc?gag?cgt?ttc?gtc?gat 403

Arg?Leu?Gly?Val?Ile?Ala?Val?Asn?Ala?Ala?Gly?Glu?Arg?Phe?Val?Asp

90 95 100

gaa?tcc?gtc?tcc?tac?cac?cgc?ttc?gtg?cgc?gcc?atg?tac?gaa?tcc?aac 451

Glu?Ser?Val?Ser?Tyr?His?Arg?Phe?Val?Arg?Ala?Met?Tyr?Glu?Ser?Asn

105 110 115

aaa?acc?acc?ccg?act?gtt?tca?gcc?tgg?ctc?att?gtt?gat?tcc?cac?acc 499

Lys?Thr?Thr?Pro?Thr?Val?Ser?Ala?Trp?Leu?Ile?Val?Asp?Ser?His?Thr

120 125 130

ctg?gca?aaa?tac?ggc?ctc?ggc?atg?atc?acc?atg?cca?cac?ctg?cct?aaa 547

Leu?Ala?Lys?Tyr?Gly?Leu?Gly?Met?Ile?Thr?Met?Pro?His?Leu?Pro?Lys

135 140 145

ctc?gct?ctg?caa?aaa?tac?atc?gac?tcc?gga?tac?ctg?cac?gca?gga?tca 595

Leu?Ala?Leu?Gln?Lys?Tyr?Ile?Asp?Ser?Gly?Tyr?Leu?His?Ala?Gly?Ser

150 155 160 165

tcc?ttg?gat?gaa?ttg?gca?cgc?agc?att?ggt?gtg?gac?gct?cgc?ggc?ctg 643

Ser?Leu?Asp?Glu?Leu?Ala?Arg?Ser?Ile?Gly?Val?Asp?Ala?Arg?Gly?Leu

170 175 180

gaa?caa?acc?gtc?aaa?cgc?tac?aat?acc?ttc?gct?aaa?acg?ggt?atc?gac 691

Glu?Gln?Thr?Val?Lys?Arg?Tyr?Asn?Thr?Phe?Ala?Lys?Thr?Gly?Ile?Asp

185 190 195

gaa?gac?ttc?cac?aag?ggc?gaa?ctc?ctc?ttc?ggt?caa?gcc?gcc?ggc?gat 739

Glu?Asp?Phe?His?Lys?Gly?Glu?Leu?Leu?Phe?Gly?Gln?Ala?Ala?Gly?Asp

200 205 210

cca?gac?aac?aag?cca?aac?ccc?aac?gtc?gga?cca?atc?aag?aag?gga?ccg 787

Pro?Asp?Asn?Lys?Pro?Asn?Pro?Asn?Val?Gly?Pro?Ile?Lys?Lys?Gly?Pro

215 220 225

ttc?tac?gca?atc?gct?gta?gtc?cca?acc?cct?ctg?gcc?act?gcc?ttt?ggc 835

Phe?Tyr?Ala?Ile?Ala?Val?Val?Pro?Thr?Pro?Leu?Ala?Thr?Ala?Phe?Gly

230 235 240 245

atc?agc?atc?aac?ccc?aac?gga?cag?gtt?gtt?agt?gaa?gat?ggg?gag?ccc 883

Ile?Ser?Ile?Asn?Pro?Asn?Gly?Gln?Val?Val?Ser?Glu?Asp?Gly?Glu?Pro

250 255 260

atc?att?gga?ctg?tac?tcc?gca?gga?aat?gat?gcc?caa?tct?gtc?atg?gct 931

Ile?Ile?Gly?Leu?Tyr?Ser?Ala?Gly?Asn?Asp?Ala?Gln?Ser?Val?Met?Ala

265 270 275

tct?gaa?tat?cct?ggt?gct?ggt?tca?cag?gtt?ggt?tcc?gga?atg?acc?ttt 979

Ser?Glu?Tyr?Pro?Gly?Ala?Gly?Ser?Gln?Val?Gly?Ser?Gly?Met?Thr?Phe

280 285 290

ggt?tgg?atc?gca?gca?cag?cac?gcg?gtg?ggg?aaa?gcg?gga?aaa?tcc?gga 1027

Gly?Trp?Ile?Ala?Ala?Gln?His?Ala?Val?Gly?Lys?Ala?Gly?Lys?Ser?Gly

295 300 305

gga?gct?aag?gca?gga?tat?gcc?gcg?tct?tct?aag?taattgcttg?gtgggttgct 1080

Gly?Ala?Lys?Ala?Gly?Tyr?Ala?Ala?Ser?Ser?Lys

310 315 320

tac

1083

<210>252

<211>320

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>252

Val?Asn?Lys?Gly?Val?Val?Leu?Val?Ala?Gly?Gly?Phe?Ser?Gln?Asn?Pro

1 5 10 15

Glu?Leu?Arg?Met?Lys?Tyr?Met?Pro?Glu?Pro?Thr?Pro?Gln?Phe?Ser?Arg

20 25 30

Thr?Asn?Glu?Ser?Ala?Thr?Gly?Asp?Thr?Met?Ala?Leu?Ala?Ala?Lys?Val

35 40 45

Gly?Ala?Arg?Leu?Gly?Asp?Asp?Asn?Gly?Glu?Asn?Ala?Leu?Trp?Phe?Pro

50 55 60

Ser?Ser?Ile?Gly?Thr?Arg?Ala?Asp?Gly?Ser?Thr?Ala?Val?Tyr?Pro?His

65 70 75 80

Ile?Trp?Asp?Arg?Gly?Arg?Leu?Gly?Val?Ile?Ala?Val?Asn?Ala?Ala?Gly

85 90 95

Glu?Arg?Phe?Val?Asp?Glu?Ser?Val?Ser?Tyr?His?Arg?Phe?Val?Arg?Ala

100 105 110

Met?Tyr?Glu?Ser?Asn?Lys?Thr?Thr?Pro?Thr?Val?Ser?Ala?Trp?Leu?Ile

115 120 125

Val?Asp?Ser?His?Thr?Leu?Ala?Lys?Tyr?Gly?Leu?Gly?Met?Ile?Thr?Met

130 135 140

Pro?His?Leu?Pro?Lys?Leu?Ala?Leu?Gln?Lys?Tyr?Ile?Asp?Ser?Gly?Tyr

145 150 155 160

Leu?His?Ala?Gly?Ser?Ser?Leu?Asp?Glu?Leu?Ala?Arg?Ser?Ile?Gly?Val

165 170 175

Asp?Ala?Arg?Gly?Leu?Glu?Gln?Thr?Val?Lys?Arg?Tyr?Asn?Thr?Phe?Ala

180 185 190

Lys?Thr?Gly?Ile?Asp?Glu?Asp?Phe?His?Lys?Gly?Glu?Leu?Leu?Phe?Gly

195 200 205

Gln?Ala?Ala?Gly?Asp?Pro?Asp?Ash?Lys?Pro?Asn?Pro?Asn?Val?Gly?Pro

210 215 220

Ile?Lys?Lys?Gly?Pro?Phe?Tyr?Ala?Ile?Ala?Val?Val?Pro?Thr?Pro?Leu

225 230 235 240

Ala?Thr?Ala?Phe?Gly?Ile?Ser?Ile?Asn?Pro?Asn?Gly?Gln?Val?Val?Ser

245 250 255

Glu?Asp?Gly?Glu?Pro?Ile?Ile?Gly?Leu?Tyr?Ser?Ala?Gly?Asn?Asp?Ala

260 265 270

Gln?Ser?Val?Met?Ala?Ser?Glu?Tyr?Pro?Gly?Ala?Gly?Ser?Gln?Val?Gly

275 280 285

Ser?Gly?Met?Thr?Phe?Gly?Trp?Ile?Ala?Ala?Gln?His?Ala?Val?Gly?Lys

290 295 300

Ala?Gly?Lys?Ser?Gly?Gly?Ala?Lys?Ala?Gly?Tyr?Ala?Ala?Ser?Ser?Lys

305 310 315 320

<210>253

<211>1428

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1405)

<223>RXN01166

<400>253

accgtaccca?cagacacacc?agaattaaca?gaaacagact?gaaaaacaac?atcgctcgac 60

atgcgcgtaa?tcctaacccg?cgcacactaa?tgtggccgat?atg?ggc?tac?acc?aac 115

Met?Gly?Tyr?Thr?Asn

1 5

ctc?aac?gac?aca?cgg?gtc?ttg?cgc?gcc?ggg?tca?tgt?gat?gcc?tgg?tgg 163

Leu?Asn?Asp?Thr?Arg?Val?Leu?Arg?Ala?Gly?Ser?Cys?Asp?Ala?Trp?Trp

10 15 20

cgc?acg?atg?tct?ccg?cta?gtg?cag?cag?gga?agt?gag?gca?gtc?ttt?cgg 211

Arg?Thr?Met?Ser?Pro?Leu?Val?Gln?Gln?Gly?Ser?Glu?Ala?Val?Phe?Arg

25 30 35

cgc?atc?atg?ggt?ctc?tcg?cgg?cgt?cct?gat?cgg?aaa?cct?ggc?ttt?gac 259

Arg?Ile?Met?Gly?Leu?Ser?Arg?Arg?Pro?Asp?Arg?Lys?Pro?Gly?Phe?Asp

40 45 50

gat?gtc?cca?cat?ttc?ggc?gca?gct?gtt?cga?gtt?ccc?ggt?cta?aaa?cac 307

Asp?Val?Pro?His?Phe?Gly?Ala?Ala?Val?Arg?Val?Pro?Gly?Leu?Lys?His

55 60 65

ggc?acg?ttg?gtc?aat?gct?gca?ccc?ttg?aaa?gtt?ttg?ggc?gca?cgg?ggc 355

Gly?Thr?Leu?Val?Asn?Ala?Ala?Pro?Leu?Lys?Val?Leu?Gly?Ala?Arg?Gly

70 75 80 85

gag?ccc?aac?ccc?gcg?agt?tcg?tac?cgt?ttt?gaa?tac?atc?acc?ggt?gat 403

Glu?Pro?Asn?Pro?Ala?Ser?Ser?Tyr?Arg?Phe?Glu?Tyr?Ile?Thr?Gly?Asp

90 95 100

tcc?gca?ggt?cga?gcc?atc?act?gcg?acc?ggc?gct?gtc?ctc?ttt?tcc?aca 451

Ser?Ala?Gly?Arg?Ala?Ile?Thr?Ala?Thr?Gly?Ala?Val?Leu?Phe?Ser?Thr

105 110 115

cgc?ccc?tgg?aca?acc?ggc?ccg?cgt?ccc?gcg?atc?gcc?atg?gct?cca?tcc 499

Arg?Pro?Trp?Thr?Thr?Gly?Pro?Arg?Pro?Ala?Ile?Ala?Met?Ala?Pro?Ser

120 125 130

acc?caa?ggc?gtc?gca?cag?cac?tgc?gat?ccc?tcc?cac?acc?tgc?gcc?atc 547

Thr?Gln?Gly?Val?Ala?Gln?His?Cys?Asp?Pro?Ser?His?Thr?Cys?Ala?Ile

135 140 145

gga?ctc?aac?gca?ttc?tat?gac?aaa?ccc?ttc?gac?gca?atc?att?gct?tac 595

Gly?Leu?Asn?Ala?Phe?Tyr?Asp?Lys?Pro?Phe?Asp?Ala?Ile?Ile?Ala?Tyr

150 155 160 165

gaa?ctc?ccc?gtc?atc?ctc?tgg?ttt?cta?gct?cac?gga?ctt?gac?gtt?gtg 643

Glu?Leu?Pro?Val?Ile?Leu?Trp?Phe?Leu?Ala?His?Gly?Leu?Asp?Val?Val

170 175 180

ttc?atc?gat?tac?ccc?cgc?gac?ccc?gca?acc?ggc?gtc?caa?tac?tat?tgc 691

Phe?Ile?Asp?Tyr?Pro?Arg?Asp?Pro?Ala?Thr?Gly?Val?Gln?Tyr?Tyr?Cys

185 190 195

gat?tcc?atc?gct?gca?gct?aaa?tcg?ctt?ctc?gac?gcc?gtc?ctc?gcc?tcc 739

Asp?Ser?Ile?Ala?Ala?Ala?Lys?Ser?Leu?Leu?Asp?Ala?Val?Leu?Ala?Ser

200 205 210

aga?caa?ctc?ggc?ctt?tca?ccg?gaa?gca?ccg?ctt?ggc?ctg?tgg?gga?ttc 787

Arg?Gln?Leu?Gly?Leu?Ser?Pro?Glu?Ala?Pro?Leu?Gly?Leu?Trp?Gly?Phe

215 220 225

tcc?caa?gga?ggc?ggc?gcc?act?ggc?tgg?gct?gca?caa?ttg?cag?gat?tac 835

Ser?Gln?Gly?Gly?Gly?Ala?Thr?Gly?Trp?Ala?Ala?Gln?Leu?Gln?Asp?Tyr

230 235 240 245

gca?cct?gat?gtc?cgc?cca?aag?gca?gcg?gtc?gtg?ggc?gct?cca?cca?gtg 883

Ala?Pro?Asp?Val?Arg?Pro?Lys?Ala?Ala?Val?Val?Gly?Ala?Pro?Pro?Val

250 255 260

gat?ctc?ttc?cgc?gtc?ttg?gac?act?gtc?gac?ggc?gga?ttg?ctc?acc?gga 931

Asp?Leu?Phe?Arg?Val?Leu?Asp?Thr?Val?Asp?Gly?Gly?Leu?Leu?Thr?Gly

265 270 275

gtg?att?gcc?tac?gcc?atc?gcg?gga?ctt?gca?gtg?aac?tct?tca?gag?atg 979

Val?Ile?Ala?Tyr?Ala?Ile?Ala?Gly?Leu?Ala?Val?Asn?Ser?Ser?Glu?Met

280 285 290

ttt?gag?gaa?atc?atg?tcg?gtg?tta?aat?gaa?cgc?gga?gtc?agt?gat?gtg 1027

Phe?Glu?Glu?Ile?Met?Ser?Val?Leu?Asn?Glu?Arg?Gly?Val?Ser?Asp?Val

295 300 305

ctg?aaa?aat?atc?acc?agc?tgc?gcg?gga?ggt?tcc?ttg?ttg?gcc?agt?ggc 1075

Leu?Lys?Asn?Ile?Thr?Ser?Cys?Ala?Gly?Gly?Ser?Leu?Leu?Ala?Ser?Gly

310 315 320 325

tac?tcg?tct?tcc?cgc?ggg?tgg?aca?cat?cag?ggc?acg?ccg?ctg?gca?gac 1123

Tyr?Ser?Ser?Ser?Arg?Gly?Trp?Thr?His?Gln?Gly?Thr?Pro?Leu?Ala?Asp

330 335 340

att?ctg?gac?gat?ctg?cca?ctt?gtt?gtc?gct?gag?ttt?ggg?aag?caa?aag 1171

Ile?Leu?Asp?Asp?Leu?Pro?Leu?Val?Val?Ala?Glu?Phe?Gly?Lys?Gln?Lys

345 350 355

ctg?ggt?cgt?gtg?gcg?cca?gaa?atc?cca?gtg?ctg?ttg?tgg?ggc?tct?aaa 1219

Leu?Gly?Arg?Val?Ala?Pro?Glu?Ile?Pro?Val?Leu?Leu?Trp?Gly?Ser?Lys

360 365 370

aat?gat?gat?gtc?att?ccc?att?gat?ccc?att?agg?gaa?ttg?cgt?gat?agc 1267

Asn?Asp?Asp?Val?Ile?Pro?Ile?Asp?Pro?Ile?Arg?Glu?Leu?Arg?Asp?Ser

375 380 385

tgg?gcg?gac?aag?ggt?acg?cca?ttg?acc?tgg?cat?gaa?tcc?caa?gcg?ccg 1315

Trp?Ala?Asp?Lys?Gly?Thr?Pro?Leu?Thr?Trp?His?Glu?Ser?Gln?Ala?Pro

390 395 400 405

cgt?gtg?cca?gga?cgc?aca?ggt?ctc?aac?cat?ttc?ggg?ccc?tat?ttt?aga 1363

Arg?Val?Pro?Gly?Arg?Thr?Gly?Leu?Asn?His?Phe?Gly?Pro?Tyr?Phe?Arg

410 415 420

aac?ctg?gaa?aag?tac?tcg?gga?tgg?ctc?ata?gat?cat?ctt?gtc 1405

Asn?Leu?Glu?Lys?Tyr?Ser?Gly?Trp?Leu?Ile?Asp?His?Leu?Val

425 430 435

tgagtgccgt?tttaaaggct?cgg 1428

<210>254

<211>435

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>254

Met?Gly?Tyr?Thr?Asn?Leu?Asn?Asp?Thr?Arg?Val?Leu?Arg?Ala?Gly?Ser

1 5 10 15

Cys?Asp?Ala?Trp?Trp?Arg?Thr?Met?Ser?Pro?Leu?Val?Gln?Gln?Gly?Ser

20 25 30

Glu?Ala?Val?Phe?Arg?Arg?Ile?Met?Gly?Leu?Ser?Arg?Arg?Pro?Asp?Arg

35 40 45

Lys?Pro?Gly?Phe?Asp?Asp?Val?Pro?His?Phe?Gly?Ala?Ala?Val?Arg?Val

50 55 60

Pro?Gly?Leu?Lys?His?Gly?Thr?Leu?Val?Asn?Ala?Ala?Pro?Leu?Lys?Val

65 70 75 80

Leu?Gly?Ala?Arg?Gly?Glu?Pro?Asn?Pro?Ala?Ser?Ser?Tyr?Arg?Phe?Glu

85 90 95

Tyr?Ile?Thr?Gly?Asp?Ser?Ala?Gly?Arg?Ala?Ile?Thr?Ala?Thr?Gly?Ala

100 105 110

Val?Leu?Phe?Ser?Thr?Arg?Pro?Trp?Thr?Thr?Gly?Pro?Arg?Pro?Ala?Ile

115 120 125

Ala?Met?Ala?Pro?Ser?Thr?Gln?Gly?Val?Ala?Gln?His?Cys?Asp?Pro?Ser

130 135 140

His?Thr?Cys?Ala?Ile?Gly?Leu?Asn?Ala?Phe?Tyr?Asp?Lys?Pro?Phe?Asp

145 150 155 160

Ala?Ile?Ile?Ala?Tyr?Glu?Leu?Pro?Val?Ile?Leu?Trp?Phe?Leu?Ala?His

165 170 175

Gly?Leu?Asp?Val?Val?Phe?Ile?Asp?Tyr?Pro?Arg?Asp?Pro?Ala?Thr?Gly

180 185 190

Val?Gln?Tyr?Tyr?Cys?Asp?Ser?Ile?Ala?Ala?Ala?Lys?Ser?Leu?Leu?Asp

195 200 205

Ala?Val?Leu?Ala?Ser?Arg?Gln?Leu?Gly?Leu?Ser?Pro?Glu?Ala?Pro?Leu

210 215 220

Gly?Leu?Trp?Gly?Phe?Ser?Gln?Gly?Gly?Gly?Ala?Thr?Gly?Trp?Ala?Ala

225 230 235 240

Gln?Leu?Gln?Asp?Tyr?Ala?Pro?Asp?Val?Arg?Pro?Lys?Ala?Ala?Val?Val

245 250 255

Gly?Ala?Pro?Pro?Val?Asp?Leu?Phe?Arg?Val?Leu?Asp?Thr?Val?Asp?Gly

260 265 270

Gly?Leu?Leu?Thr?Gly?Val?Ile?Ala?Tyr?Ala?Ile?Ala?Gly?Leu?Ala?Val

275 280 285

Asn?Ser?Ser?Glu?Met?Phe?Glu?Glu?Ile?Met?Ser?Val?Leu?Asn?Glu?Arg

290 295 300

Gly?Val?Ser?Asp?Val?Leu?Lys?Asn?Ile?Thr?Ser?Cys?Ala?Gly?Gly?Ser

305 310 315 320

Leu?Leu?Ala?Ser?Gly?Tyr?Ser?Ser?Ser?Arg?Gly?Trp?Thr?His?Gln?Gly

325 330 335

Thr?Pro?Leu?Ala?Asp?Ile?Leu?Asp?Asp?Leu?Pro?Leu?Val?Val?Ala?Glu

340 345 350

Phe?Gly?Lys?Gln?Lys?Leu?Gly?Arg?Val?Ala?Pro?Glu?Ile?Pro?Val?Leu

355 360 365

Leu?Trp?Gly?Ser?Lys?Asn?Asp?Asp?Val?Ile?Pro?Ile?Asp?Pro?Ile?Arg

370 375 380

Glu?Leu?Arg?Asp?Ser?Trp?Ala?Asp?Lys?Gly?Thr?Pro?Leu?Thr?Trp?His

385 390 395 400

Glu?Ser?Gln?Ala?Pro?Arg?Val?Pro?Gly?Arg?Thr?Gly?Leu?Asn?His?Phe

405 410 415

Gly?Pro?Tyr?Phe?Arg?Asn?Leu?Glu?Lys?Tyr?Ser?Gly?Trp?Leu?Ile?Asp

420 425 430

His?Leu?Val

435

<210>255

<211>1281

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1258)

<223>RXN02001

<400>255

gcggtttcgt?catggataag?gactgtgttc?gggaccattg?cgatactcgt?gtcaaaaggc 60

gatagtccag?catagaccgt?gctttatcga?aggtgaaccc?atg?ccc?gtt?atc?aat 115

Met?Pro?Val?Ile?Asn

1 5

agt?atc?gcc?agt?ttt?tcc?gac?gag?atg?acc?cgc?tgg?cgg?cgt?cac?ctg 163

Ser?Ile?Ala?Ser?Phe?Ser?Asp?Glu?Met?Thr?Arg?Trp?Arg?Arg?His?Leu

10 15 20

cat?caa?aac?ccc?gaa?atc?agc?ttt?gat?tgt?gtg?gaa?act?gcg?gcc?ttc 211

His?Gln?Asn?Pro?Glu?Ile?Ser?Phe?Asp?Cys?Val?Glu?Thr?Ala?Ala?Phe

25 30 35

gtg?gcc?gag?cag?ctg?cgc?agc?ttc?ggg?gtg?gat?gaa?att?cac?acc?ggc 259

Val?Ala?Glu?Gln?Leu?Arg?Ser?Phe?Gly?Val?Asp?Glu?Ile?His?Thr?Gly

40 45 50

atc?gcg?aaa?acc?ggt?atc?atc?gcc?ctg?att?cac?ggg?cgc?gag?gct?ggc 307

Ile?Ala?Lys?Thr?Gly?Ile?Ile?Ala?Leu?Ile?His?Gly?Arg?Glu?Ala?Gly

55 60 65

ccc?gtc?gtc?ggc?ctg?cgc?gcc?gat?atg?gac?gcg?ctg?ccg?ctg?acc?gag 355

Pro?Val?Val?Gly?Leu?Arg?Ala?Asp?Met?Asp?Ala?Leu?Pro?Leu?Thr?Glu

70 75 80 85

att?acc?ggc?gtc?gac?tat?gcc?tcg?acc?acc?ccc?gga?aaa?atg?cac?gcc 403

Ile?Thr?Gly?Val?Asp?Tyr?Ala?Ser?Thr?Thr?Pro?Gly?Lys?Met?His?Ala

90 95 100

tgc?ggc?cac?gac?ggc?cac?acg?acc?atg?ctg?ctg?ggc?gcc?gcc?aaa?tat 451

Cys?Gly?His?Asp?Gly?His?Thr?Thr?Met?Leu?Leu?Gly?Ala?Ala?Lys?Tyr

105 110 115

ctg?gcc?gag?acg?cgc?aat?ttc?gca?ggt?acc?gtc?gcg?ctg?atc?ttc?cag 499

Leu?Ala?Glu?Thr?Arg?Asn?Phe?Ala?Gly?Thr?Val?Ala?Leu?Ile?Phe?Gln

120 125 130

cct?gcg?gaa?gaa?aac?ggc?ggc?ggc?gcg?ggc?gtt?atg?gtc?gat?gaa?ggc 547

Pro?Ala?Glu?Glu?Asn?Gly?Gly?Gly?Ala?Gly?Val?Met?Val?Asp?Glu?Gly

135 140 145

gtc?ctc?gac?cgc?ttt?gcc?atc?gcc?gaa?gtc?tac?gcc?ctg?cac?aac?cag 595

Val?Leu?Asp?Arg?Phe?Ala?Ile?Ala?Glu?Val?Tyr?Ala?Leu?His?Asn?Gln

150 155 160 165

ccc?ggc?ctg?ccg?ctt?ggc?cat?ttt?atg?acg?aca?gcc?ggc?ccg?atc?atg 643

Pro?Gly?Leu?Pro?Leu?Gly?His?Phe?Met?Thr?Thr?Ala?Gly?Pro?Ile?Met

170 175 180

gcc?gct?gtc?gac?acg?ttc?gac?atc?aac?att?acc?gga?cgc?ggc?ggc?cac 691

Ala?Ala?Val?Asp?Thr?Phe?Asp?Ile?Asn?Ile?Thr?Gly?Arg?Gly?Gly?His

185 190 195

ggt?gcc?aaa?ccg?cac?caa?acc?cgc?gac?ccc?atc?gtc?gca?gcc?gtc?gga 739

Gly?Ala?Lys?Pro?His?Gln?Thr?Arg?Asp?Pro?Ile?Val?Ala?Ala?Val?Gly

200 205 210

att?gtc?caa?gcg?ttt?caa?acg?ata?gtc?agc?cgg?aat?cac?aat?ccg?gtc 787

Ile?Val?Gln?Ala?Phe?Gln?Thr?Ile?Val?Ser?Arg?Asn?His?Asn?Pro?Val

215 220 225

gag?gac?ctt?gtc?gtg?tcg?gtc?acg?caa?atc?cac?acc?ggc?agc?gcc?gat 835

Glu?Asp?Leu?Val?Val?Ser?Val?Thr?Gln?Ile?His?Thr?Gly?Ser?Ala?Asp

230 235 240 245

aat?atc?atc?ccc?gaa?acc?gcc?tat?atc?aac?ggc?act?gtc?cgc?acc?ttc 883

Asn?Ile?Ile?Pro?Glu?Thr?Ala?Tyr?Ile?Asn?Gly?Thr?Val?Arg?Thr?Phe

250 255 260

aac?aaa?gac?gtg?cag?gcc?atg?gtc?atc?acg?cgg?atg?gaa?gaa?atc?gtc 931

Asn?Lys?Asp?Val?Gln?Ala?Met?Val?Ile?Thr?Arg?Met?Glu?Glu?Ile?Val

265 270 275

gcg?ggc?caa?gct?gca?gcc?tat?ggg?gtc?gag?gcg?acg?ctg?acc?tac?aac 979

Ala?Gly?Gln?Ala?Ala?Ala?Tyr?Gly?Val?Glu?Ala?Thr?Leu?Thr?Tyr?Asn

280 285 290

cgc?aac?tat?ccc?gcc?acc?att?aac?gac?gcc?gcc?aaa?gcc?gcc?atc?gct 1027

Arg?Asn?Tyr?Pro?Ala?Thr?Ile?Asn?Asp?Ala?Ala?Lys?Ala?Ala?Ile?Ala

295 300 305

gcc?gaa?gtc?gcg?ggc?gag?gtc?ggc?ctc?ggg?gtc?aac?ccg?aac?ggc?tcg 1075

Ala?Glu?Val?Ala?Gly?Glu?Val?Gly?Leu?Gly?Val?Asn?Pro?Asn?Gly?Ser

310 315 320 325

cgc?ggg?atg?ggg?gcc?gag?gat?ttc?tcg?tat?ttc?ctc?gaa?aag?cgc?ccg 1123

Arg?Gly?Met?Gly?Ala?Glu?Asp?Phe?Ser?Tyr?Phe?Leu?Glu?Lys?Arg?Pro

330 335 340

ggt?gcc?tac?ctg?ttc?gtc?ggt?aat?ggc?gac?agc?gcg?ggc?ctt?cac?aac 1171

Gly?Ala?Tyr?Leu?Phe?Val?Gly?Asn?Gly?Asp?Ser?Ala?Gly?Leu?His?Asn

345 350 355

ccc?gcc?tat?aat?ttc?aac?gac?gag?gcc?gcg?ccc?tac?ggc?gca?tcg?ttc 1219

Pro?Ala?Tyr?Asn?Phe?Asn?Asp?Glu?Ala?Ala?Pro?Tyr?Gly?Ala?Ser?Phe

360 365 370

ttg?gcc?cgc?atg?gca?gaa?cgc?ccc?ttg?ccg?tta?aag?ggc?tgatccatgg 1268

Leu?Ala?Arg?Met?Ala?Glu?Arg?Pro?Leu?Pro?Leu?Lys?Gly

375 380 385

cgctcgaaga?tgc 1281

<210>256

<211>386

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>256

Met?Pro?Val?Ile?Asn?Ser?Ile?Ala?Ser?Phe?Ser?Asp?Glu?Met?Thr?Arg

1 5 10 15

Trp?Arg?Arg?His?Leu?His?Gln?Asn?Pro?Glu?Ile?Ser?Phe?Asp?Cys?Val

20 25 30

Glu?Thr?Ala?Ala?Phe?Val?Ala?Glu?Gln?Leu?Arg?Ser?Phe?Gly?Val?Asp

35 40 45

Glu?Ile?His?Thr?Gly?Ile?Ala?Lys?Thr?Gly?Ile?Ile?Ala?Leu?Ile?His

50 55 60

Gly?Arg?Glu?Ala?Gly?Pro?Val?Val?Gly?Leu?Arg?Ala?Asp?Met?Asp?Ala

65 70 75 80

Leu?Pro?Leu?Thr?Glu?Ile?Thr?Gly?Val?Asp?Tyr?Ala?Ser?Thr?Thr?Pro

85 90 95

Gly?Lys?Met?His?Ala?Cys?Gly?His?Asp?Gly?His?Thr?Thr?Met?Leu?Leu

100 105 110

Gly?Ala?Ala?Lys?Tyr?Leu?Ala?Glu?Thr?Arg?Asn?Phe?Ala?Gly?Thr?Val

115 120 125

Ala?Leu?Ile?Phe?Gln?Pro?Ala?Glu?Glu?Asn?Gly?Gly?Gly?Ala?Gly?Val

130 135 140

Met?Val?Asp?Glu?Gly?Val?Leu?Asp?Arg?Phe?Ala?Ile?Ala?Glu?Val?Tyr

145 150 155 160

Ala?Leu?His?Asn?Gln?Pro?Gly?Leu?Pro?Leu?Gly?His?Phe?Met?Thr?Thr

165 170 175

Ala?Gly?Pro?Ile?Met?Ala?Ala?Val?Asp?Thr?Phe?Asp?Ile?Asn?Ile?Thr

180 185 190

Gly?Arg?Gly?Gly?His?Gly?Ala?Lys?Pro?His?Gln?Thr?Arg?Asp?Pro?Ile

195 200 205

Val?Ala?Ala?Val?Gly?Ile?Val?Gln?Ala?Phe?Gln?Thr?Ile?Val?Ser?Arg

210 215 220

Asn?His?Asn?Pro?Val?Glu?Asp?Leu?Val?Val?Ser?Val?Thr?Gln?Ile?His

225 230 235 240

Thr?Gly?Ser?Ala?Asp?Asn?Ile?Ile?Pro?Glu?Thr?Ala?Tyr?Ile?Asn?Gly

245 250 255

Thr?Val?Arg?Thr?Phe?Asn?Lys?Asp?Val?Gln?Ala?Met?Val?Ile?Thr?Arg

260 265 270

Met?Glu?Glu?Ile?Val?Ala?Gly?Gln?Ala?Ala?Ala?Tyr?Gly?Val?Glu?Ala

275 280 285

Thr?Leu?Thr?Tyr?Asn?Arg?Asn?Tyr?Pro?Ala?Thr?Ile?Asn?Asp?Ala?Ala

290 295 300

Lys?Ala?Ala?Ile?Ala?Ala?Glu?Val?Ala?Gly?Glu?Val?Gly?Leu?Gly?Val

305 310 315 320

Asn?Pro?Asn?Gly?Ser?Arg?Gly?Met?Gly?Ala?Glu?Asp?Phe?Ser?Tyr?Phe

325 330 335

Leu?Glu?Lys?Arg?Pro?Gly?Ala?Tyr?Leu?Phe?Val?Gly?Asn?Gly?Asp?Ser

340 345 350

Ala?Gly?Leu?His?Asn?Pro?Ala?Tyr?Asn?Phe?Asn?Asp?Glu?Ala?Ala?Pro

355 360 365

Tyr?Gly?Ala?Ser?Phe?Leu?Ala?Arg?Met?Ala?Glu?Arg?Pro?Leu?Pro?Leu

370 375 380

Lys?Gly

385

<210>257

<211>570

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(547)

<223>RXN03145

<400>257

agaggtgttt?aaattcccgc?ctctgcccca?gatttaaaac?tatgatgagg?gatagcttct 60

caattttcca?ggttttccaa?aatgaaagag?gttcacgcac?atg?cct?act?tat?act 115

Met?Pro?Thr?Tyr?Thr

1 5

tgt?tgg?tcg?caa?aga?att?cgc?att?tct?agg?gaa?gcc?aag?caa?cgc?atc 163

Cys?Trp?Ser?Gln?Arg?Ile?Arg?Ile?Ser?Arg?Glu?Ala?Lys?Gln?Arg?Ile

10 15 20

gct?gag?gca?atc?acc?gat?gcc?cac?cat?gaa?tta?gcg?cat?gct?ccc?aag 211

Ala?Glu?Ala?Ile?Thr?Asp?Ala?His?His?Glu?Leu?Ala?His?Ala?Pro?Lys

25 30 35

tat?ttg?gtg?cag?gtg?att?ttc?aat?gag?gtg?gag?cct?gat?tct?tat?ttc 259

Tyr?Leu?Val?Gln?Val?Ile?Phe?Asn?Glu?Val?Glu?Pro?Asp?Ser?Tyr?Phe

40 45 50

att?gcg?gcg?cag?tcg?gcg?tcg?gaa?aac?cac?att?tgg?gtc?caa?gca?acg 307

Ile?Ala?Ala?Gln?Ser?Ala?Ser?Glu?Asn?His?Ile?Trp?Val?Gln?Ala?Thr

55 60 65

att?cgt?tcg?ggg?cgt?aca?gag?aag?caa?aaa?gag?gaa?ctt?ctg?ctt?cgg 355

Ile?Arg?Ser?Gly?Arg?Thr?Glu?Lys?Gln?Lys?Glu?Glu?Leu?Leu?Leu?Arg

70 75 80 85

ctg?aca?caa?gag?atc?gcg?ctg?att?ctt?ggg?atc?ccc?aat?gaa?gaa?gta 403

Leu?Thr?Gln?Glu?Ile?Ala?Leu?Ile?Leu?Gly?Ile?Pro?Asn?Glu?Glu?Val

90 95 100

tgg?gta?tat?ata?ccg?gag?att?cct?ggt?tcc?aat?atg?acg?gaa?tat?ggc 451

Trp?Val?Tyr?Ile?Pro?Glu?Ile?Pro?Gly?Ser?Asn?Met?Thr?Glu?Tyr?Gly

105 110 115

cgt?ctc?ctc?atg?gaa?cct?ggc?gaa?gag?gag?aag?tgg?ttt?aat?tcg?ctt 499

Arg?Leu?Leu?Met?Glu?Pro?Gly?Glu?Glu?Glu?Lys?Trp?Phe?Asn?Ser?Leu

120 125 130

ccc?gaa?ggc?ctg?cgg?gaa?agg?ttg?acc?gag?cta?gaa?gga?tcg?tca?gaa 547

Pro?Glu?Gly?Leu?Arg?Glu?Arg?Leu?Thr?Glu?Leu?Glu?Gly?Ser?Ser?Glu

135 140 145

tagctctcga?ataggccatt?tct 570

<210>258

<211>149

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>258

Met?Pro?Thr?Tyr?Thr?Cys?Trp?Ser?Gln?Arg?Ile?Arg?Ile?Ser?Arg?Glu

1 5 10 15

Ala?Lys?Gln?Arg?Ile?Ala?Glu?Ala?Ile?Thr?Asp?Ala?His?His?Glu?Leu

20 25 30

Ala?His?Ala?Pro?Lys?Tyr?Leu?Val?Gln?Val?Ile?Phe?Asn?Glu?Val?Glu

35 40 45

Pro?Asp?Ser?Tyr?Phe?Ile?Ala?Ala?Gln?Ser?Ala?Ser?Glu?Asn?His?Ile

50 55 60

Trp?Val?Gln?Ala?Thr?Ile?Arg?Ser?Gly?Arg?Thr?Glu?Lys?Gln?Lys?Glu

65 70 75 80

Glu?Leu?Leu?Leu?Arg?Leu?Thr?Gln?Glu?Ile?Ala?Leu?Ile?Leu?Gly?Ile

85 90 95

Pro?Asn?Glu?Glu?Val?Trp?Val?Tyr?Ile?Pro?Glu?Ile?Pro?Gly?Ser?Asn

100 105 110

Met?Thr?Glu?Tyr?Gly?Arg?Leu?Leu?Met?Glu?Pro?Gly?Glu?Glu?Glu?Lys

115 120 125

Trp?Phe?Asn?Ser?Leu?Pro?Glu?Gly?Leu?Arg?Glu?Arg?Leu?Thr?Glu?Leu

130 135 140

Glu?Gly?Ser?Ser?Glu

145

<210>259

<211>1083

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1060)

<223>RXN01466

<400>259

aatccatgat?cccaaactac?ctcaaagcgc?ttgtaggcta?agacttatgg?atacacaacg 60

cggctcattg?cggggaaaag?ctcataaagc?aaggctaaag?atg?acg?cca?aat?ggt 115

Met?Thr?Pro?Asn?Gly

1 5

cgc?agg?caa?ctc?ctc?ctg?gag?cgt?ggc?gca?gca?ttt?agc?aaa?aac?cgt 163

Arg?Arg?Gln?Leu?Leu?Leu?Glu?Arg?Gly?Ala?Ala?Phe?Ser?Lys?Asn?Arg

10 15 20

acc?ccg?ggt?cta?aaa?cac?gtc?gac?cgc?cac?acc?atc?gtg?gac?tcc?gac 211

Thr?Pro?Gly?Leu?Lys?His?Val?Asp?Arg?His?Thr?Ile?Val?Asp?Ser?Asp

25 30 35

ggc?ctc?agc?atc?cac?acg?tac?atg?gtt?ggc?cat?gcc?gaa?aat?gcc?acg 259

Gly?Leu?Ser?Ile?His?Thr?Tyr?Met?Val?Gly?His?Ala?Glu?Asn?Ala?Thr

40 45 50

gca?acg?gtc?gtg?ttc?atc?cac?ggc?ttc?acc?ctc?gcc?gcc?gaa?gtg?tat 307

Ala?Thr?Val?Val?Phe?Ile?His?Gly?Phe?Thr?Leu?Ala?Ala?Glu?Val?Tyr

55 60 65

tac?atg?cag?gtc?gac?tac?cta?caa?acc?ttt?tac?cca?aat?att?aaa?agc 355

Tyr?Met?Gln?Val?Asp?Tyr?Leu?Gln?Thr?Phe?Tyr?Pro?Asn?Ile?Lys?Ser

70 75 80 85

gtg?ctt?atc?gac?gcc?cgc?ggc?cac?ggc?gcc?acc?ggc?cag?atc?cgc?cca 403

Val?Leu?Ile?Asp?Ala?Arg?Gly?His?Gly?Ala?Thr?Gly?Gln?Ile?Arg?Pro

90 95 100

gag?ctc?tgc?acc?atc?gaa?gga?aca?gcg?aac?gat?gtt?ctc?gca?gcc?atc 451

Glu?Leu?Cys?Thr?Ile?Glu?Gly?Thr?Ala?Asn?Asp?Val?Leu?Ala?Ala?Ile

105 110 115

cac?gaa?cac?gca?ccg?acc?ggc?ccg?ctc?att?ttg?gtt?ggg?cat?tcc?ctc 499

His?Glu?His?Ala?Pro?Thr?Gly?Pro?Leu?Ile?Leu?Val?Gly?His?Ser?Leu

120 125 130

ggc?gga?ctc?acg?gca?ctt?aac?ctg?gtt?aaa?cgg?gca?gat?cac?tca?ctt 547

Gly?Gly?Leu?Thr?Ala?Leu?Asn?Leu?Val?Lys?Arg?Ala?Asp?His?Ser?Leu

135 140 145

cgg?aag?agg?atc?gtc?ggc?atg?gtt?cta?gtc?gcc?aca?tcg?atc?gaa?tca 595

Arg?Lys?Arg?Ile?Val?Gly?Met?Val?Leu?Val?Ala?Thr?Ser?Ile?Glu?Ser

150 155 160 165

tta?tcc?acc?caa?ggt?cta?cca?caa?gtc?ctg?gca?tca?ccc?ctt?gcc?gac 643

Leu?Ser?Thr?Gln?Gly?Leu?Pro?Gln?Val?Leu?Ala?Ser?Pro?Leu?Ala?Asp

170 175 180

aac?atc?aaa?aac?gcc?gtc?gaa?gca?gcc?ccc?aac?gat?gcc?caa?aaa?ttc 691

Asn?Ile?Lys?Asn?Ala?Val?Glu?Ala?Ala?Pro?Asn?Asp?Ala?Gln?Lys?Phe

185 190 195

cgc?caa?tac?gcc?acc?aca?ttt?cta?gcc?ccc?acc?ctg?gcc?acc?gca?gtc 739

Arg?Gln?Tyr?Ala?Thr?Thr?Phe?Leu?Ala?Pro?Thr?Leu?Ala?Thr?Ala?Val

200 205 210

ttc?caa?cga?gac?aca?aac?gat?gaa?gtc?atc?gat?ttc?cac?gcc?gcc?atg 787

Phe?Gln?Arg?Asp?Thr?Asn?Asp?Glu?Val?Ile?Asp?Phe?His?Ala?Ala?Met

215 220 225

atc?cac?gaa?acc?ccc?ttg?gat?acc?ttc?gtc?ggt?ttc?ttc?gac?gac?ctc 835

Ile?His?Glu?Thr?Pro?Leu?Asp?Thr?Phe?Val?Gly?Phe?Phe?Asp?Asp?Leu

230 235 240 245

caa?gaa?cac?gac?gaa?ctc?gat?gcc?gca?cca?gca?ttg?gaa?ggc?ctc?aaa 883

Gln?Glu?His?Asp?Glu?Leu?Asp?Ala?Ala?Pro?Ala?Leu?Glu?Gly?Leu?Lys

250 255 260

ggc?tac?gtc?ctt?gcc?ggc?gaa?tta?gat?gat?gtc?acc?cca?att?agc?caa 931

Gly?Tyr?Val?Leu?Ala?Gly?Glu?Leu?Asp?Asp?Val?Thr?Pro?Ile?Ser?Gln

265 270 275

gcc?gac?cgc?atc?tgc?gaa?gtc?tgg?ccc?ggc?gca?cgc?ctt?caa?atc?gca 979

Ala?Asp?Arg?Ile?Cys?Glu?Val?Trp?Pro?Gly?Ala?Arg?Leu?Gln?Ile?Ala

280 285 290

gaa?gga?gca?ggt?cat?atg?ctt?ccg?ctt?gaa?gcg?cca?gga?atc?ctc?aat 1027

Glu?Gly?Ala?Gly?His?Met?Leu?Pro?Leu?Glu?Ala?Pro?Gly?Ile?Leu?Asn

295 300 305

aat?gcg?atc?ggc?aac?att?ttg?gac?ggg?ctg?ggc?tgaggaacct?ggttcgggcg 1080

Asn?Ala?Ile?Gly?Asn?Ile?Leu?Asp?Gly?Leu?Gly

310 315 320

tgg

1083

<210>260

<211>320

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>260

Met?Thr?Pro?Asn?Gly?Arg?Arg?Gln?Leu?Leu?Leu?Glu?Arg?Gly?Ala?Ala

1 5 10 15

Phe?Ser?Lys?Asn?Arg?Thr?Pro?Gly?Leu?Lys?His?Val?Asp?Arg?His?Thr

20 25 30

Ile?Val?Asp?Ser?Asp?Gly?Leu?Ser?Ile?His?Thr?Tyr?Met?Val?Gly?His

35 40 45

Ala?Glu?Asn?Ala?Thr?Ala?Thr?Val?Val?Phe?Ile?His?Gly?Phe?Thr?Leu

50 55 60

Ala?Ala?Glu?Val?Tyr?Tyr?Met?Gln?Val?Asp?Tyr?Leu?Gln?Thr?Phe?Tyr

65 70 75 80

Pro?Asn?Ile?Lys?Ser?Val?Leu?Ile?Asp?Ala?Arg?Gly?His?Gly?Ala?Thr

85 90 95

Gly?Gln?Ile?Arg?Pro?Glu?Leu?Cys?Thr?Ile?Glu?Gly?Thr?Ala?Asn?Asp

100 105 110

Val?Leu?Ala?Ala?Ile?His?Glu?His?Ala?Pro?Thr?Gly?Pro?Leu?Ile?Leu

115 120 125

Val?Gly?His?Ser?Leu?Gly?Gly?Leu?Thr?Ala?Leu?Asn?Leu?Val?Lys?Arg

130 135 140

Ala?Asp?His?Ser?Leu?Arg?Lys?Arg?Ile?Val?Gly?Met?Val?Leu?Val?Ala

145 150 155 160

Thr?Ser?Ile?Glu?Ser?Leu?Ser?Thr?Gln?Gly?Leu?Pro?Gln?Val?Leu?Ala

165 170 175

Ser?Pro?Leu?Ala?Asp?Asn?Ile?Lys?Asn?Ala?Val?Glu?Ala?Ala?Pro?Asn

180 185 190

Asp?Ala?Gln?Lys?Phe?Arg?Gln?Tyr?Ala?Thr?Thr?Phe?Leu?Ala?Pro?Thr

195 200 205

Leu?Ala?Thr?Ala?Val?Phe?Gln?Arg?Asp?Thr?Asn?Asp?Glu?Val?Ile?Asp

210 215 220

Phe?His?Ala?Ala?Met?Ile?His?Glu?Thr?Pro?Leu?Asp?Thr?Phe?Val?Gly

225 230 235 240

Phe?Phe?Asp?Asp?Leu?Gln?Glu?His?Asp?Glu?Leu?Asp?Ala?Ala?Pro?Ala

245 250 255

Leu?Glu?Gly?Leu?Lys?Gly?Tyr?Val?Leu?Ala?Gly?Glu?Leu?Asp?Asp?Val

260 265 270

Thr?Pro?Ile?Ser?Gln?Ala?Asp?Arg?Ile?Cys?Glu?Val?Trp?Pro?Gly?Ala

275 280 285

Arg?Leu?Gln?Ile?Ala?Glu?Gly?Ala?Gly?His?Met?Leu?Pro?Leu?Glu?Ala

290 295 300

Pro?Gly?Ile?Leu?Asn?Asn?Ala?Ile?Gly?Asn?Ile?Leu?Asp?Gly?Leu?Gly

305 310 315 320

<210>261

<211>1137

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1114)

<223>RXN01145

<400>261

taatgtagtt?gtctgcccaa?gcgagttaaa?ctcccacgat?ttacagtggg?gggcagacat 60

cttttcacca?aaatttttac?gaaaggcgag?attttctccc?atg?gct?att?gaa?ctg 115

Met?Ala?Ile?Glu?Leu

1 5

ctt?tat?gat?gct?gac?gct?gac?ctc?tcc?ttg?atc?cag?ggc?cgt?aag?gtt 163

Leu?Tyr?Asp?Ala?Asp?Ala?Asp?Leu?Ser?Leu?Ile?Gln?Gly?Arg?Lys?Val

10 15 20

gcc?atc?gtt?ggc?tac?ggc?tcc?cag?ggc?cac?gca?cac?tcc?cag?aac?ctc 211

Ala?Ile?Val?Gly?Tyr?Gly?Ser?Gln?Gly?His?Ala?His?Ser?Gln?Asn?Leu

25 30 35

cgc?gat?tct?ggc?gtt?gag?gtt?gtc?att?ggt?ctg?cgc?gag?ggc?tcc?aag 259

Arg?Asp?Ser?Gly?Val?Glu?Val?Val?Ile?Gly?Leu?Arg?Glu?Gly?Ser?Lys

40 45 50

tcc?gca?gag?aag?gca?aag?gaa?gca?ggc?ttc?gag?gtc?aag?acc?acc?gct 307

Ser?Ala?Glu?Lys?Ala?Lys?Glu?Ala?Gly?Phe?Glu?Val?Lys?Thr?Thr?Ala

55 60 65

gag?gct?gca?gct?tgg?gct?gac?gtc?atc?atg?ctc?ctg?gct?cca?gac?acc 355

Glu?Ala?Ala?Ala?Trp?Ala?Asp?Val?Ile?Met?Leu?Leu?Ala?Pro?Asp?Thr

70 75 80 85

tcc?cag?gca?gaa?atc?ttc?acc?aac?gac?atc?gag?cca?aac?ctg?aac?gca 403

Ser?Gln?Ala?Glu?lle?Phe?ThrAsn?Asp?Ile?Glu?Pro?Asn?Leu?Asn?Ala

90 95 100

ggc?gac?gca?ctg?ctg?ttc?ggc?cac?ggc?ctg?aac?att?cacttc?gac?ctg 451

Gly?Asp?Ala?Leu?Leu?Phe?Gly?His?Gly?Leu?Asn?Ile?His?Phe?Asp?Leu

105 110 115

atc?aag?cca?gct?gac?gac?atc?atc?gtt?ggc?atg?gtt?gcg?cca?aag?ggc 499

Ile?Lys?Pro?Ala?Asp?Asp?Ile?Ile?Val?Gly?Met?Val?Ala?Pro?Lys?Gly

120 125 130

cca?ggc?cac?ttg?gtt?cgc?cgt?cag?ttc?gtt?gat?ggc?aag?ggt?gtt?cct 547

Pro?Gly?His?Leu?Val?Arg?Arg?Gln?Phe?Val?Asp?Gly?Lys?Gly?Val?Pro

135 140 145

tgc?ctc?atc?gca?gtc?gac?cag?gac?cca?acc?gga?acc?gca?cag?gct?ctg 595

Cys?Leu?Ile?Ala?Val?Asp?Gln?Asp?Pro?Thr?Gly?Thr?Ala?Gln?Ala?Leu

150 155 160 165

acc?ctg?tcc?tac?gca?gca?gca?atc?ggt?ggc?gca?cgc?gca?ggc?gtt?atc 643

Thr?Leu?Ser?Tyr?Ala?Ala?Ala?Ile?Gly?Gly?Ala?Arg?Ala?Gly?Val?Ile

170 175 180

cca?acc?acc?ttc?gaa?gct?gag?acc?gtc?acc?gac?ctc?ttc?ggc?gag?cag 691

Pro?Thr?Thr?Phe?Glu?Ala?Glu?Thr?Val?Thr?Asp?Leu?Phe?Gly?Glu?Gln

185 190 195

gct?gtt?ctc?tgc?ggt?ggc?acc?gag?gaa?ctg?gtc?aag?gtt?ggc?ttc?gag 739

Ala?Val?Leu?Cys?Gly?Gly?Thr?Glu?Glu?Leu?Val?Lys?Val?Gly?Phe?Glu

200 205 210

gtt?ctc?acc?gaa?gct?ggc?tac?gag?cca?gag?atg?gca?tacttc?gag?gtt 787

Val?Leu?Thr?Glu?Ala?Gly?Tyr?Glu?Pro?Glu?Met?Ala?Tyr?Phe?Glu?Val

215 220 225

ctt?cac?gag?ctc?aag?ctc?atc?gtt?gac?ctc?atg?ttc?gaa?ggt?ggc?atc 835

Leu?His?Glu?Leu?Lys?Leu?Ile?Val?Asp?Leu?Met?Phe?Glu?Gly?Gly?Ile

230 235 240 245

agc?aac?atg?aac?tac?tct?gtt?tct?gac?acc?gct?gag?ttc?ggt?ggc?tac 883

Ser?Asn?Met?Asn?Tyr?Ser?Val?Ser?Asp?Thr?Ala?Glu?Phe?Gly?Gly?Tyr

250 255 260

ctc?tcc?ggc?cca?cgc?gtc?atc?gat?gca?gac?acc?aag?tcc?cgc?atg?aag 931

Leu?Ser?Gly?Pro?Arg?Val?Ile?Asp?Ala?Asp?Thr?Lys?Ser?Arg?Met?Lys

265 270 275

gac?atc?ctg?acc?gat?atc?cag?gac?ggc?acc?ttc?acc?aag?cgc?ctc?atc 979

Asp?Ile?Leu?Thr?Asp?Ile?Gln?Asp?Gly?Thr?Phe?Thr?Lys?Arg?Leu?Ile

280 285 290

gca?aac?gtt?gag?aac?ggc?aac?acc?gag?ctt?gag?ggc?ctt?cgt?gct?tcc 1027

Ala?Ash?Val?Glu?Asn?Gly?Asn?Thr?Glu?Leu?Glu?Gly?Leu?Arg?Ala?Ser

295 300 305

tac?aac?aac?cac?cca?atc?gag?gag?acc?ggc?gct?aag?ctc?cgc?gac?ctc 1075

Tyr?Asn?Asn?His?Pro?Ile?Glu?Glu?Thr?Gly?Ala?Lys?Leu?Arg?Asp?Leu

310 315 320 325

atg?agc?tgg?gtc?aag?gtt?gac?gct?cgc?gca?gaa?acc?gct?taagtttcac 1124

Met?Ser?Trp?Val?Lys?Val?Asp?Ala?Arg?Ala?Glu?Thr?Ala

330 335

ccctttgacg?gct 1137

<210>262

<211>338

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>262

Met?Ala?Ile?Glu?Leu?Leu?Tyr?Asp?Ala?Asp?Ala?Asp?Leu?Ser?Leu?Ile

1 5 10 15

Gln?Gly?Arg?Lys?Val?Ala?Ile?Val?Gly?Tyr?Gly?Ser?Gln?Gly?His?Ala

20 25 30

His?Ser?Gln?Asn?Leu?Arg?Asp?Ser?Gly?Val?Glu?Val?Val?Ile?Gly?Leu

35 40 45

Arg?Glu?Gly?Ser?Lys?Ser?Ala?Glu?Lys?Ala?Lys?Glu?Ala?Gly?Phe?Glu

50 55 60

Val?Lys?Thr?Thr?Ala?Glu?Ala?Ala?Ala?Trp?Ala?Asp?Val?Ile?Met?Leu

65 70 75 80

Leu?Ala?Pro?Asp?Thr?Ser?Gln?Ala?Glu?Ile?Phe?Thr?Asn?Asp?Ile?Glu

85 90 95

Pro?Asn?Leu?Asn?Ala?Gly?Asp?Ala?Leu?Leu?Phe?Gly?His?Gly?Leu?Asn

100 105 110

Ile?His?Phe?Asp?Leu?Ile?Lys?Pro?Ala?Asp?Asp?Ile?Ile?Val?Gly?Met

115 120 125

Val?Ala?Pro?Lys?Gly?Pro?Gly?His?Leu?Val?Arg?Arg?Gln?Phe?Val?Asp

130 135 140

Gly?Lys?Gly?Val?Pro?Cys?Leu?Ile?Ala?Val?Asp?Gln?Asp?Pro?Thr?Gly

145 150 155 160

Thr?Ala?Gln?Ala?Leu?Thr?Leu?Ser?Tyr?Ala?Ala?Ala?Ile?Gly?Gly?Ala

165 170 175

Arg?Ala?Gly?Val?Ile?Pro?Thr?Thr?Phe?Glu?Ala?Glu?Thr?Val?Thr?Asp

180 185 190

Leu?Phe?Gly?Glu?Gln?Ala?Val?Leu?Cys?Gly?Gly?Thr?Glu?Glu?Leu?Val

195 200 205

Lys?Val?Gly?Phe?Glu?Val?Leu?Thr?Glu?Ala?Gly?Tyr?Glu?Pro?Glu?Met

210 215 220

Ala?Tyr?Phe?Glu?Val?Leu?His?Glu?Leu?Lys?Leu?Ile?Val?Asp?Leu?Met

225 230 235 240

Phe?Glu?Gly?Gly?Ile?Ser?Asn?Met?Asn?Tyr?Ser?Val?Ser?Asp?Thr?Ala

245 250 255

Glu?Phe?Gly?Gly?Tyr?Leu?Ser?Gly?Pro?Arg?Val?Ile?Asp?Ala?Asp?Thr

260 265 270

Lys?Ser?Arg?Met?Lys?Asp?Ile?Leu?Thr?Asp?Ile?Gln?Asp?Gly?Thr?Phe

275 280 285

Thr?Lys?Arg?Leu?Ile?Ala?Asn?Val?Glu?Asn?Gly?Asn?Thr?Glu?Leu?Glu

290 295 300

Gly?Leu?Arg?Ala?Ser?Tyr?Asn?Asn?His?Pro?Ile?Glu?Glu?Thr?Gly?Ala

305 310 315 320

Lys?Leu?Arg?Asp?Leu?Met?Ser?Trp?Val?Lys?Val?Asp?Ala?Arg?Ala?Glu

325 330 335

Thr?Ala

<210>263

<211>487

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(487)

<223>RXN03088

<400>263

tcatggcacc?gggacctggc?atcgtagcta?aggtttcttt?tgatgatttc?tccgacgtca 60

ccggcggcga?tgaactcctc?gaattggagg?caaagaacta?atg?ggt?caa?acc?cgc 115

Met?Gly?Gln?Thr?Arg

1 5

atc?att?tcc?ggc?gac?gca?cgc?ggc?cgc?aag?atc?gaa?gta?cca?cca?gca 163

Ile?Ile?Ser?Gly?Asp?Ala?Arg?Gly?Arg?Lys?Ile?Glu?Val?Pro?Pro?Ala

10 15 20

ggt?acc?cgc?ccc?acc?tct?gac?cgc?gca?cgc?gaa?ggt?ctc?ttc?tcc?tca 211

Gly?Thr?Arg?Pro?Thr?Ser?Asp?Arg?Ala?Arg?Glu?Gly?Leu?Phe?Ser?Ser

25 30 35

ctg?cag?gtc?cgt?ttc?gga?ttt?gag?ggc?cag?cgc?gtc?ctc?gac?att?itt 259

Leu?Gln?Val?Arg?Phe?Gly?Phe?Glu?Gly?Gln?Arg?Val?Leu?Asp?Ile?Phe

40 45 50

gcc?ggc?tcc?ggc?gca?ctc?gga?ttg?gaa?gct?gcc?tcc?agg?ggt?gcc?gat 307

Ala?Gly?Ser?Gly?Ala?Leu?Gly?Leu?Glu?Ala?Ala?Ser?Arg?Gly?Ala?Asp

55 60 65

gag?gta?gtt?ctg?gtc?gag?tcg?aat?cct?aag?gcc?gta?gag?gta?att?cga 355

Glu?Val?Val?Leu?Val?Glu?Ser?Asn?Pro?Lys?Ala?Val?Glu?Val?Ile?Arg

70 75 80 85

cgg?aat?gtg?gac?gtc?gta?aag?cat?cct?cgc?gta?acc?gtc?gca?gag?atg 403

Arg?Asn?Val?Asp?Val?Val?Lys?His?Pro?Arg?Val?Thr?Val?Ala?Glu?Met

90 95 100

aaa?gca?tcc?acc?tac?ctt?gcg?tcc?gca?ccc?gat?aag?ttt?ttc?acg?atg 451

Lys?Ala?Ser?Thr?Tyr?Leu?Ala?Ser?Ala?Pro?Asp?Lys?Phe?Phe?Thr?Met

105 110 115

gtg?ctc?gcc?gac?ccg?ccc?tat?gag?ctt?gcg?acg?acg 487

Val?Leu?Ala?Asp?Pro?Pro?Tyr?Glu?Leu?Ala?Thr?Thr

120 125

<210>264

<211>129

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>264

Met?Gly?Gln?Thr?Arg?Ile?Ile?Ser?Gly?Asp?Ala?Arg?Gly?Arg?Lys?Ile

1 5 10 15

Glu?Val?Pro?Pro?Ala?Gly?Thr?Arg?Pro?Thr?Ser?Asp?Arg?Ala?Arg?Glu

20 25 30

Gly?Leu?Phe?Ser?Ser?Leu?Gln?Val?Arg?Phe?Gly?Phe?Glu?Gly?Gln?Arg

35 40 45

Val?Leu?Asp?Ile?Phe?Ala?Gly?Ser?Gly?Ala?Leu?Gly?Leu?Glu?Ala?Ala

50 55 60

Ser?Arg?Gly?Ala?Asp?Glu?Val?Val?Leu?Val?Glu?Ser?Asn?Pro?Lys?Ala

65 70 75 80

Val?Glu?Val?Ile?Arg?Arg?Asn?Val?Asp?Val?Val?Lys?His?Pro?Arg?Val

85 90 95

Thr?Val?Ala?Glu?Met?Lys?Ala?Ser?Thr?Tyr?Leu?Ala?Ser?Ala?Pro?Asp

100 105 110

Lys?Phe?Phe?Thr?Met?Val?Leu?Ala?Asp?Pro?Pro?Tyr?Glu?Leu?Ala?Thr

115 120 125

Thr

<210>265

<211>639

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(616)

<223>RXN02952

<400>265

tccaaaccgc?tgtttctgct?cgtggcgaat?cctggatatt?gaagtaattg?aaatccgaga 60

cctgatcttt?gatctcgcta?cctcattcac?aagcgccggc?atg?agc?tcc?cca?gca 115

Met?Ser?Ser?Pro?Ala

1 5

ctt?gac?gct?gca?aaa?cag?cgc?ctt?gct?gaa?tcc?gat?ggc?ctg?atc?gct 163

Leu?Asp?Ala?Ala?Lys?Gln?Arg?Leu?Ala?Glu?Ser?Asp?Gly?Leu?Ile?Ala

10 15 20

gtt?acc?cca?gta?ttt?acc?gcg?agc?tac?tcc?ggc?atc?ttc?aag?atg?ttc 211

Val?Thr?Pro?Val?Phe?Thr?Ala?Ser?Tyr?Ser?Gly?Ile?Phe?Lys?Met?Phe

25 30 35

ttt?gat?gtc?ctg?gac?ccc?aag?acc?att?gtg?ggt?ctg?ccc?acc?atc?att 259

Phe?Asp?Val?Leu?Asp?Pro?Lys?Thr?Ile?Val?Gly?Leu?Pro?Thr?Ile?Ile

40 45 50

gcg?gca?tct?gct?gga?acg?gca?cgc?cac?tca?ttg?gtt?ctc?gac?cac?gcc 307

Ala?Ala?Ser?Ala?Gly?Thr?Ala?Arg?His?Ser?Leu?Val?Leu?Asp?His?Ala

55 60 65

atc?cga?cca?ctg?ttt?acc?tac?ttg?cga?gca?gtt?gtc?gta?ccc?acc?ggc 355

Ile?Arg?Pro?Leu?Phe?Thr?Tyr?Leu?Arg?Ala?Val?Val?Val?Pro?Thr?Gly

70 75 80 85

gtg?ttc?gca?gcc?acg?gaa?gat?ttc?ggc?act?gaa?gct?ggc?gca?gac?att 403

Val?Phe?Ala?Ala?Thr?Glu?Asp?Phe?Gly?Thr?Glu?Ala?Gly?Ala?Asp?Ile

90 95 100

gaa?cgt?cgc?gtg?aac?cgc?gca?gct?ggc?gaa?tta?gcg?aca?ctc?atg?ttg 451

Glu?Arg?Arg?Val?Asn?Arg?Ala?Ala?Gly?Glu?Leu?Ala?Thr?Leu?Met?Leu

105 110 115

cag?gat?tac?tcc?agt?gtg?caa?ggc?ctt?ggg?ggc?gca?acc?gcg?aac?caa 499

Gln?Asp?Tyr?Ser?Ser?Val?Gln?Gly?Leu?Gly?Gly?Ala?Thr?Ala?Asn?Gln

120 125 130

gac?gct?gac?ctt?tcc?ttc?cgt?cgc?acc?act?ggc?gtg?acc?ccg?gga?gag 547

Asp?Ala?Asp?Leu?Ser?Phe?Arg?Arg?Thr?Thr?Gly?Val?Thr?Pro?Gly?Glu

135 140 145

aac?ttc?agc?agc?ttt?gcc?gat?ctt?tct?caa?agg?aca?cga?cgg?aaa?cgg 595

Asn?Phe?Ser?Ser?Phe?Ala?Asp?Leu?Ser?Gln?Arg?Thr?Arg?Arg?Lys?Arg

150 155 160 165

cta?aat?tcg?cgg?atc?tcc?gtt?taaggcattg?aagcatttgg?agg 639

Leu?Asn?Ser?Arg?Ile?Ser?Val

170

<210>266

<211>172

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>266

Met?Ser?Ser?Pro?Ala?Leu?Asp?Ala?Ala?Lys?Gln?Arg?Leu?Ala?Glu?Ser

1 5 10 15

Asp?Gly?Leu?Ile?Ala?Val?Thr?Pro?Val?Phe?Thr?Ala?Ser?Tyr?Ser?Gly

20 25 30

Ile?Phe?Lys?Met?Phe?Phe?Asp?Val?Leu?Asp?Pro?Lys?Thr?Ile?Val?Gly

35 40 45

Leu?Pro?Thr?Ile?Ile?Ala?Ala?Ser?Ala?Gly?Thr?Ala?Arg?His?Ser?Leu

50 55 60

Val?Leu?Asp?His?Ala?Ile?Arg?Pro?Leu?Phe?Thr?Tyr?Leu?Arg?Ala?Val

65 70 75 80

Val?Val?Pro?Thr?Gly?Val?Phe?Ala?Ala?Thr?Glu?Asp?Phe?Gly?Thr?Glu

85 90 95

Ala?Gly?Ala?Asp?Ile?Glu?Arg?Arg?Val?Asn?Arg?Ala?Ala?Gly?Glu?Leu

100 105 110

Ala?Thr?Leu?Met?Leu?Gln?Asp?Tyr?Ser?Ser?Val?Gln?Gly?Leu?Gly?Gly

115 120 125

Ala?Thr?Ala?Asn?Gln?Asp?Ala?Asp?Leu?Ser?Phe?Arg?Arg?Thr?Thr?Gly

130 135 140

Val?Thr?Pro?Gly?Glu?Asn?Phe?Ser?Ser?Phe?Ala?Asp?Leu?Ser?Gln?Arg

145 150 155 160

Thr?Arg?Arg?Lys?Arg?Leu?Asn?Ser?Arg?Ile?Ser?Val

165 170

<210>267

<211>1044

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1021)

<223>RXN00513

<400>267

cacagcgtac?gcacgagctt?gaggatcttt?cagaactcaa?cattgaattg?gatgccgata 60

ttttggccaa?ggctcctgtg?attccggaag?gactgttctg?atg?gcg?ggt?ttg?ttt 115

Met?Ala?Gly?Leu?Phe

1 5

tcc?tct?gct?gtt?gca?cca?acg?gag?cgt?cga?aaa?gca?tta?cgc?gcg?gca 163

Ser?Ser?Ala?Val?Ala?Pro?Thr?Glu?Arg?Arg?Lys?Ala?Leu?Arg?Ala?Ala

10 15 20

ctg?gct?gcg?cct?gaa?att?gcc?cgc?atg?cct?ggt?gca?ttc?tcc?ccg?ctg 211

Leu?Ala?Ala?Pro?Glu?Ile?Ala?Arg?Met?Pro?Gly?Ala?Phe?Ser?Pro?Leu

25 30 35

gcg?gcg?cgc?gca?atc?cag?gaa?gcc?gga?ttt?gaa?ggc?gtg?tac?gtc?tcg 259

Ala?Ala?Arg?Ala?Ile?Gln?Glu?Ala?Gly?Phe?Glu?Gly?Val?Tyr?Val?Ser

40 45 50

ggc?gcc?gtc?gtg?gcg?gct?gac?ctt?gca?ttg?ccg?gat?atc?ggc?ttg?acc 307

Gly?Ala?Val?Val?Ala?Ala?Asp?Leu?Ala?Leu?Pro?Asp?Ile?Gly?Leu?Thr

55 60 65

aca?ttg?acc?gaa?gtg?gcg?cac?cgc?tcc?cgg?cag?atc?gca?cgc?gtg?aca 355

Thr?Leu?Thr?Glu?Val?Ala?His?Arg?Ser?Arg?Gln?Ile?Ala?Arg?Val?Thr

70 75 80 85

gac?ttg?ccc?gtg?ctg?gtc?gac?gcc?gac?acc?ggc?ttc?ggc?gaa?ccc?atg 403

Asp?Leu?Pro?Val?Leu?Val?Asp?Ala?Asp?Thr?Gly?Phe?Gly?Glu?Pro?Met

90 95 100

tcc?gca?gcg?cgc?acc?gtc?tcc?gaa?ctc?gaa?gat?gca?ggt?gtc?gcg?ggc 451

Ser?Ala?Ala?Arg?Thr?Val?Ser?Glu?Leu?Glu?Asp?Ala?Gly?Val?Ala?Gly

105 110 115

tgc?cac?ctg?gaa?gat?caa?gtc?aac?ccc?aaa?cgc?tgt?ggg?cac?ctg?gac 499

Cys?His?Leu?Glu?Asp?Gln?Val?Asn?Pro?Lys?Arg?Cys?Gly?His?Leu?Asp

120 125 130

gga?aaa?gaa?gta?gtg?ggc?acg?gac?atc?atg?gtt?cgt?cgc?atc?gcc?gca 547

Gly?Lys?Glu?Val?Val?Gly?Thr?Asp?Ile?Met?Val?Arg?Arg?Ile?Ala?Ala

135 140 145

gct?gtc?aac?gag?cgt?cgc?gat?gag?caa?ttc?gtc?atc?tgc?gct?cgc?acc 595

Ala?Val?Asn?Glu?Arg?Arg?Asp?Glu?Gln?Phe?Val?Ile?Cys?Ala?Arg?Thr

150 155 160 165

gac?gcc?gcg?gga?gtg?gaa?ggc?atc?gac?tcc?gcg?atc?gag?cgc?gcc?aaa 643

Asp?Ala?Ala?Gly?Val?Glu?Gly?Ile?Asp?Ser?Ala?Ile?Glu?Arg?Ala?Lys

170 175 180

gct?tac?gcg?gat?gcc?ggc?gcc?gac?atg?atc?ttc?acc?gaa?gcg?ctg?tac 691

Ala?Tyr?Ala?Asp?Ala?Gly?Ala?Asp?Met?Ile?Phe?Thr?Glu?Ala?Leu?Tyr

185 190 195

agc?cct?gca?gat?ttt?gaa?aaa?ttc?cgc?gcg?gcc?gtc?gac?att?ccg?ctg 739

Ser?Pro?Ala?Asp?Phe?Glu?Lys?Phe?Arg?Ala?Ala?Val?Asp?Ile?Pro?Leu

200 205 210

ctg?gcc?aac?atg?acg?gaa?ttt?ggc?aaa?acc?gaa?ctt?ctg?ccc?gcg?cag 787

Leu?Ala?Asn?Met?Thr?Glu?Phe?Gly?Lys?Thr?Glu?Leu?Leu?Pro?Ala?Gln

215 220 225

ctt?ctg?gaa?gac?atc?gga?tac?aac?gca?gtg?atc?tac?cca?gtg?acc?ctg 835

Leu?Leu?Glu?Asp?Ile?Gly?Tyr?Asn?Ala?Val?Ile?Tyr?Pro?Val?Thr?Leu

230 235 240 245

ctg?cgc?att?gcg?atg?gga?cag?gtc?gaa?caa?gct?ctc?ggc?gac?att?gca 883

Leu?Arg?Ile?Ala?Met?Gly?Gln?Val?Glu?Gln?Ala?Leu?Gly?Asp?Ile?Ala

250 255 260

aac?acc?gga?arc?caa?acc?gac?tgg?gtc?gac?cgg?atg?caa?cac?cga?tcc 931

Asn?Thr?Gly?Ile?Gln?Thr?Asp?Trp?Val?Asp?Arg?Met?Gln?His?Arg?Ser

265 270 275

agg?ctg?tat?gag?ctg?ctg?cgc?tac?aac?gag?tac?aac?gct?ttc?gac?cag 979

Arg?Leu?Tyr?Glu?Leu?Leu?Arg?Tyr?Asn?Glu?Tyr?Asn?Ala?Phe?Asp?Gln

280 285 290

caa?gta?ttc?acc?tat?tcc?gct?gac?agc?tac?aag?ccc?atc?ttc 1021

Gln?Val?Phe?Thr?Tyr?Ser?Ala?Asp?Ser?Tyr?Lys?Pro?Ile?Phe

295 300 305

taacccgcct?atatataagg?agt 1044

<210>268

<211>307

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>268

Met?Ala?Gly?Leu?Phe?Ser?Ser?Ala?Val?Ala?Pro?Thr?Glu?Arg?Arg?Lys

1 5 10 15

Ala?Leu?Arg?Ala?Ala?Leu?Ala?Ala?Pro?Glu?Ile?Ala?Arg?Met?Pro?Gly

20 25 30

Ala?Phe?Ser?Pro?Leu?Ala?Ala?Arg?Ala?Ile?Gln?Glu?Ala?Gly?Phe?Glu

35 40 45

Gly?Val?Tyr?Val?Ser?Gly?Ala?Val?Val?Ala?Ala?Asp?Leu?Ala?Leu?Pro

50 55 60

Asp?Ile?Gly?Leu?Thr?Thr?Leu?Thr?Glu?Val?Ala?His?Arg?Ser?Arg?Gln

65 70 75 80

Ile?Ala?Arg?Val?Thr?Asp?Leu?Pro?Val?Leu?Val?Asp?Ala?Asp?Thr?Gly

85 90 95

Phe?Gly?Glu?Pro?Met?Ser?Ala?Ala?Arg?Thr?Val?Ser?Glu?Leu?Glu?Asp

100 105 110

Ala?Gly?Val?Ala?Gly?Cys?His?Leu?Glu?Asp?Gln?Val?Asn?Pro?Lys?Arg

115 120 125

Cys?Gly?His?Leu?Asp?Gly?Lys?Glu?Val?Val?Gly?Thr?Asp?Ile?Met?Val

130 135 140

Arg?Arg?Ile?Ala?Ala?Ala?Val?Asn?Glu?Arg?Arg?Asp?Glu?Gln?Phe?Val

145 150 155 160

Ile?Cys?Ala?Arg?Thr?Asp?Ala?Ala?Gly?Val?Glu?Gly?Ile?Asp?Ser?Ala

165 170 175

Ile?Glu?Arg?Ala?Lys?Ala?Tyr?Ala?Asp?Ala?Gly?Ala?Asp?Met?Ile?Phe

180 185 190

Thr?Glu?Ala?Leu?Tyr?Ser?Pro?Ala?Asp?Phe?Glu?Lys?Phe?Arg?Ala?Ala

195 200 205

Val?Asp?Ile?Pro?Leu?Leu?Ala?Asn?Met?Thr?Glu?Phe?Gly?Lys?Thr?Glu

210 215 220

Leu?Leu?Pro?Ala?Gln?Leu?Leu?Glu?Asp?Ile?Gly?Tyr?Asn?Ala?Val?Ile

225 230 235 240

Tyr?Pro?Val?Thr?Leu?Leu?Arg?Ile?Ala?Met?Gly?Gln?Val?Glu?Gln?Ala

245 250 255

Leu?Gly?Asp?Ile?Ala?Asn?Thr?Gly?Ile?Gln?Thr?Asp?Trp?Val?Asp?Arg

260 265 270

Met?Gln?His?Arg?Ser?Arg?Leu?Tyr?Glu?Leu?Leu?Arg?Tyr?Asn?Glu?Tyr

275 280 285

Asn?Ala?Phe?Asp?Gln?Gln?Val?Phe?Thr?Tyr?Ser?Ala?Asp?Ser?Tyr?Lys

290 295 300

Pro?Ile?Phe

305

<210>269

<211>957

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(934)

<223>RXN01152

<400>269

agtgaaggat?ctgatgtggt?ttgaacaagc?cctggaagcc?tatctggtaa?attaacgccg 60

agttcaatca?agacaagcac?acagaagaaa?gtgagggctc?atg?ccc?tac?tca?ggt 115

Met?Pro?Tyr?Ser?Gly

1 5

ccg?ttc?caa?gca?ggc?gac?cgc?gtt?cag?ctc?acc?gac?gct?aaa?cgc?cgc 163

Pro?Phe?Gln?Ala?Gly?Asp?Arg?Val?Gln?Leu?Thr?Asp?Ala?Lys?Arg?Arg

10 15 20

cat?ttc?acc?atc?att?ttg?gaa?cca?gga?acc?acc?tac?cac?acc?cac?cgt 211

His?Phe?Thr?Ile?Ile?Leu?Glu?Pro?Gly?Thr?Thr?Tyr?His?Thr?His?Arg

25 30 35

gga?caa?atc?gca?cac?gat?gac?arc?atc?ggc?gcc?gat?gag?ggc?act?gtt 259

Gly?Gln?Ile?Ala?His?Asp?Asp?Ile?Ile?Gly?Ala?Asp?Glu?Gly?Thr?Val

40 45 50

gtc?cac?tcc?acc?atg?ggc?tct?gat?tac?ttg?tgc?ttc?cgt?cac?ctc?atg 307

Val?His?Ser?Thr?Met?Gly?Ser?Asp?Tyr?Leu?Cys?Phe?Arg?His?Leu?Met

55 60 65

gtt?gat?cac?gtg?ctg?agc?atg?cct?cgt?ggc?gct?gca?gtt?att?tat?cca 355

Val?Asp?His?Val?Leu?Ser?Met?Pro?Arg?Gly?Ala?Ala?Val?Ile?Tyr?Pro

70 75 80 85

aag?gac?tct?gca?cag?att?ctg?gtc?gag?ggc?gat?att?ttc?cct?ggc?gcc 403

Lys?Asp?Ser?Ala?Gln?Ile?Leu?Val?Glu?Gly?Asp?Ile?Phe?Pro?Gly?Ala

90 95 100

cga?gtt?ctg?gaa?gct?ggc?gct?ggt?tcc?ggt?gca?ctg?tcc?atg?gcg?ctg 451

Arg?Val?Leu?Glu?Ala?Gly?Ala?Gly?Ser?Gly?Ala?Leu?Ser?Met?Ala?Leu

105 110 115

ctt?cgt?gca?gtg?ggt?gaa?aag?ggc?aat?gtc?atc?tcc?tac?gaa?atc?cgt 499

Leu?Arg?Ala?Val?Gly?Glu?Lys?Gly?Asn?Val?Ile?Ser?Tyr?Glu?Ile?Arg

120 125 130

gag?gat?cac?ctg?gag?tac?gca?gtc?tcc?aac?gtg?gag?gag?tacttc?ggt 547

Glu?Asp?His?Leu?Glu?Tyr?Ala?Val?Ser?Asn?Val?Glu?Glu?Tyr?Phe?Gly

135 140 145

gag?cgt?cca?gca?acc?tgg?gat?cca?cgt?ctt?ggt?gac?ctg?aaa?gaa?gtc 595

Glu?Arg?Pro?Ala?Thr?Trp?Asp?Pro?Arg?Leu?Gly?Asp?Leu?Lys?Glu?Val

150 155 160 165

acc?gtt?gag?gat?ctc?ggc?gga?cct?gtt?gac?cgc?atc?atc?ttg?gat?atg 643

Thr?Val?Glu?Asp?Leu?Gly?Gly?Pro?Val?Asp?Arg?Ile?Ile?Leu?Asp?Met

170 175 180

ctt?gag?ccg?tgg?gaa?atg?ctg?gag?acc?tgc?aag?gat?ctt?ctc?atc?cct 691

Leu?Glu?Pro?Trp?Glu?Met?Leu?Glu?Thr?Cys?Lys?Asp?Leu?Leu?Ile?Pro

185 190 195

ggt?ggt?gtg?ttt?atg?acg?tat?gtg?gcg?acc?gtg?cca?cag?ctg?atg?aag 739

Gly?Gly?Val?Phe?Met?Thr?Tyr?Val?Ala?Thr?Val?Pro?Gln?Leu?Met?Lys

200 205 210

gtc?atg?gaa?ggc?atc?cgc?gag?caa?aaa?tgc?ttc?acg?gag?cca?cgc?gcg 787

Val?Met?Glu?Gly?Ile?Arg?Glu?Gln?Lys?Cys?Phe?Thr?Glu?Pro?Arg?Ala

215 220 225

tgg?gaa?tct?ttg?gtt?cgt?gat?tgg?aag?gtg?gag?ggc?ttg?gca?aca?cgc 835

Trp?Glu?Ser?Leu?Val?Arg?Asp?Trp?Lys?Val?Glu?Gly?Leu?Ala?Thr?Arg

230 235 240 245

cct?gag?cac?cgc?atg?aat?gcc?cac?acc?gcg?ttc?ttg?gtg?ttg?acc?agg 883

Pro?Glu?His?Arg?Met?Asn?Ala?His?Thr?Ala?Phe?Leu?Val?Leu?Thr?Arg

250 255 260

cgt?ttg?gct?gat?ggc?gtg?gag?cct?cct?cgt?ccg?cag?cgt?aag?gca?cgt 931

Arg?Leu?Ala?Asp?Gly?Val?Glu?Pro?Pro?Arg?Pro?Gln?Arg?Lys?Ala?Arg

265 270 275

cga?taaaaagacc?tagttggagg?gcg 957

Arg

<210>270

<211>278

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>270

Met?Pro?Tyr?Ser?Gly?Pro?Phe?Gln?Ala?Gly?Asp?Arg?Val?Gln?Leu?Thr

1 5 10 15

Asp?Ala?Lys?Arg?Arg?His?Phe?Thr?Ile?Ile?Leu?Glu?Pro?Gly?Thr?Thr

20 25 30

Tyr?His?Thr?His?Arg?Gly?Gln?Ile?Ala?His?Asp?Asp?Ile?Ile?Gly?Ala

35 40 45

Asp?Glu?Gly?Thr?Val?Val?His?Ser?Thr?Met?Gly?Ser?Asp?Tyr?Leu?Cys

50 55 60

Phe?Arg?His?Leu?Met?Val?Asp?His?Val?Leu?Ser?Met?Pro?Arg?Gly?Ala

65 70 75 80

Ala?Val?Ile?Tyr?Pro?Lys?Asp?Ser?Ala?Gln?Ile?Leu?Val?Glu?Gly?Asp

85 90 95

Ile?Phe?Pro?Gly?Ala?Arg?Val?Leu?Glu?Ala?Gly?Ala?Gly?Ser?Gly?Ala

100 105 110

Leu?Ser?Met?Ala?Leu?Leu?Arg?Ala?Val?Gly?Glu?Lys?Gly?Asn?Val?Ile

115 120 125

Ser?Tyr?Glu?Ile?Arg?Glu?Asp?His?Leu?Glu?Tyr?Ala?Val?Ser?Asn?Val

130 135 140

Glu?Glu?Tyr?Phe?Gly?Glu?Arg?Pro?Ala?Thr?Trp?Asp?Pro?Arg?Leu?Gly

145 150 155 160

Asp?Leu?Lys?Glu?Val?Thr?Val?Glu?Asp?Leu?Gly?Gly?Pro?Val?Asp?Arg

165 170 175

Ile?Ile?Leu?Asp?Met?Leu?Glu?Pro?Trp?Glu?Met?Leu?Glu?Thr?Cys?Lys

180 185 190

Asp?Leu?Leu?Ile?Pro?Gly?Gly?Val?Phe?Met?Thr?Tyr?Val?Ala?Thr?Val

195 200 205

Pro?Gln?Leu?Met?Lys?Val?Met?Glu?Gly?Ile?Arg?Glu?Gln?Lys?Cys?Phe

210 215 220

Thr?Glu?Pro?Arg?Ala?Trp?Glu?Ser?Leu?Val?Arg?Asp?Trp?Lys?Val?Glu

225 230 235 240

Gly?Leu?Ala?Thr?Arg?Pro?Glu?His?Arg?Met?Asn?Ala?His?Thr?Ala?Phe

245 250 255

Leu?Val?Leu?Thr?Arg?Arg?Leu?Ala?Asp?Gly?Val?Glu?Pro?Pro?Arg?Pro

260 265 270

Gln?Arg?Lys?Ala?Arg?Arg

275

<210>271

<211>2025

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(2002)

<223>RXN00787

<400>271

ccagcccgcc?caataaataa?tttctctctt?ctaattgcgg?agcctcatat?attgagtacg 60

gtattttgaa?acaccttcag?cccccttttt?aggagccaca?gtg?tct?cag?cct?ctc 115

Val?Ser?Gln?Pro?Leu

1 5

agc?aag?cgt?ctc?agc?ata?cga?aaa?gca?ctc?gcc?agc?gcc?ttc?ata?gtt 163

Ser?Lys?Arg?Leu?Ser?Ile?Arg?Lys?Ala?Leu?Ala?Ser?Ala?Phe?Ile?Val

10 15 20

gcg?ctg?gcg?ttt?tcg?ctt?tcc?cca?gta?gcc?aaa?gcc?caa?gcc?aat?gaa 211

Ala?Leu?Ala?Phe?Ser?Leu?Ser?Pro?Val?Ala?Lys?Ala?Gln?Ala?Asn?Glu

25 30 35

act?ccg?acg?atg?atc?gtg?ttg?gac?aat?tca?ggc?tcc?atg?aca?gct?caa 259

Thr?Pro?Thr?Met?Ile?Val?Leu?Asp?Asn?Ser?Gly?Ser?Met?Thr?Ala?Gln

40 45 50

gat?gcc?ggc?gga?cag?acc?cgt?atc?gat?gca?gca?aaa?caa?gcc?tcc?act 307

Asp?Ala?Gly?Gly?Gln?Thr?Arg?Ile?Asp?Ala?Ala?Lys?Gln?Ala?Ser?Thr

55 60 65

cag?tta?att?aat?gac?atc?tcc?gac?cgc?acc?gac?gta?ggt?ctg?acc?tac 355

Gln?Leu?Ile?Asn?Asp?Ile?Ser?Asp?Arg?Thr?Asp?Val?Gly?Leu?Thr?Tyr

70 75 80 85

tac?ggc?gga?aac?acc?ggc?gaa?aca?gaa?gca?gac?gtt?gag?atg?gga?tgc 403

Tyr?Gly?Gly?Asn?Thr?Gly?Glu?Thr?Glu?Ala?Asp?Val?Glu?Met?Gly?Cys

90 95 100

caa?gac?gtc?acc?atc?ctt?ggc?ggc?ccc?tcc?cga?gga?aat?gca?gac?acc 451

Gln?Asp?Val?Thr?Ile?Leu?Gly?Gly?Pro?Ser?Arg?Gly?Asn?Ala?Asp?Thr

105 110 115

tta?att?gac?acg?atc?aac?agc?ctg?cag?cct?cga?ggc?ttc?acc?ccc?atc 499

Leu?Ile?Asp?Thr?Ile?Asn?Ser?Leu?Gln?Pro?Arg?Gly?Phe?Thr?Pro?Ile

120 125 130

ggc?aaa?gca?ctc?acc?gat?acc?gcc?gcc?gag?ctc?ccc?gaa?ggc?gga?aac 547

Gly?Lys?Ala?Leu?Thr?Asp?Thr?Ala?Ala?Glu?Leu?Pro?Glu?Gly?Gly?Asn

135 140 145

att?gtg?ttg?gtc?tcc?gat?ggc?atc?gcc?aac?tgc?acc?cca?ccg?gat?gtc 595

Ile?Val?Leu?Val?Ser?Asp?Gly?Ile?Ala?Asn?Cys?Thr?Pro?Pro?Asp?Val

150 155 160 165

tgc?gaa?gta?gcc?caa?gaa?ctg?gct?caa?agt?gga?atc?aac?ctg?gtt?atc 643

Cys?Glu?Val?Ala?Gln?Glu?Leu?Ala?Gln?Ser?Gly?Ile?Asn?Leu?Val?Ile

170 175 180

aac?acc?atc?gga?cta?aat?gtt?gat?cca?gca?gcg?cgc?gaa?gaa?ctg?gag 691

Asn?Thr?Ile?Gly?Leu?Asn?Val?Asp?Pro?Ala?Ala?Arg?Glu?Glu?Leu?Glu

185 190 195

tgc?atc?gct?gga?gtc?ggt?ggt?ggc?act?tac?gcg?gat?gct?tcc?gac?gcg 739

Cys?Ile?Ala?Gly?Val?Gly?Gly?Gly?Thr?Tyr?Ala?Asp?Ala?Ser?Asp?Ala

200 205 210

cag?agc?ctt?acc?gat?gcg?ctg?aca?cga?gcc?gcc?agt?agg?caa?tac?aac 787

Gln?Ser?Leu?Thr?Asp?Ala?Leu?Thr?Arg?Ala?Ala?Ser?Arg?Gln?Tyr?Asn

215 220 225

tct?tac?acc?tcc?gat?gtg?aca?aaa?att?gat?ggg?gca?tcg?gaa?caa?agc 835

Ser?Tyr?Thr?Ser?Asp?Val?Thr?Lys?Ile?Asp?Gly?Ala?Ser?Glu?Gln?Ser

230 235 240 245

gca?gcc?gta?gaa?att?gat?gag?gat?aca?gaa?cta?ttc?ctc?acc?gac?ctg 883

Ala?Ala?Val?Glu?Ile?Asp?Glu?Asp?Thr?Glu?Leu?Phe?Leu?Thr?Asp?Leu

250 255 260

cca?caa?gaa?tcc?cgc?ttt?tgg?aaa?atc?cct?gta?gag?cca?ggt?gaa?acc 931

Pro?Gln?Glu?Ser?Arg?Phe?Trp?Lys?Ile?Pro?Val?Glu?Pro?Gly?Glu?Thr

265 270 275

atc?tca?gtt?tct?gcc?aac?aca?gtt?acc?gac?cca?aca?gta?ctc?acc?atg 979

Ile?Ser?Val?Ser?Ala?Asn?Thr?Val?Thr?Asp?Pro?Thr?Val?Leu?Thr?Met

280 285 290

ggg?caa?ggc?gga?atc?aag?ctt?gaa?gcc?caa?ctc?cat?act?gaa?gag?gct 1027

Gly?Gln?Gly?Gly?Ile?Lys?Leu?Glu?Ala?Gln?Leu?His?Thr?Glu?Glu?Ala

295 300 305

cca?caa?tac?ggc?ctg?cgt?ggt?cgg?tgc?act?cgg?gtc?tca?ttt?gat?aat 1075

Pro?Gln?Tyr?Gly?Leu?Arg?Gly?Arg?Cys?Thr?Arg?Val?Ser?Phe?Asp?Asn

310 315 320 325

ttc?aag?ccc?ggc?ctt?ggt?gta?cgc?gga?atc?caa?aac?gcg?tcc?gtt?gca 1123

Phe?Lys?Pro?Gly?Leu?Gly?Val?Arg?Gly?Ile?Gln?Asn?Ala?Ser?Val?Ala

330 335 340

tca?aaa?gaa?gtg?ggc?acc?aac?aac?tgt?gac?acc?gat?gcc?atc?tac?ctc 1171

Ser?Lys?Glu?Val?Gly?Thr?Asn?Asn?Cys?Asp?Thr?Asp?Ala?Ile?Tyr?Leu

345 350 355

gaa?att?tct?aga?agc?gga?gat?tac?ctc?aac?ggg?cag?gac?att?cca?acg 1219

Glu?Ile?Ser?Arg?Ser?Gly?Asp?Tyr?Leu?Asn?Gly?Gln?Asp?Ile?Pro?Thr

360 365 370

gaa?atc?acc?atc?gag?cgc?ttc?gga?aaa?gta?gat?gaa?tca?aca?atc?gga 1267

Glu?Ile?Thr?Ile?Glu?Arg?Phe?Gly?Lys?Val?Asp?Glu?Ser?Thr?Ile?Gly

375 380 385

aat?gtc?aca?gag?gaa?cat?agc?tcc?gtc?gat?ctt?acc?gag?gct?gca?gca 1315

Asn?Val?Thr?Glu?Glu?His?Ser?Ser?Val?Asp?Leu?Thr?Glu?Ala?Ala?Ala

390 395 400 405

tca?gag?gca?cac?cct?gtc?aca?cct?ggc?cag?tgg?ttc?aca?tcg?gcc?gct 1363

Ser?Glu?Ala?His?Pro?Val?Thr?Pro?Gly?Gln?Trp?Phe?Thr?Ser?Ala?Ala

410 415 420

gat?cta?gat?ccc?gca?ggt?gag?aaa?gtc?tcc?tcc?atc?atc?gtt?cca?gga 1411

Asp?Leu?Asp?Pro?Ala?Gly?Glu?Lys?Val?Ser?Ser?Ile?Ile?Val?Pro?Gly

425 430 435

gaa?acc?cac?ttc?tat?gcg?ctg?cct?gtc?gac?tac?ggc?caa?gaa?ctg?cgc 1459

Glu?Thr?His?Phe?Tyr?Ala?Leu?Pro?Val?Asp?Tyr?Gly?Gln?Glu?Leu?Arg

440 445 450

gca?gct?gta?gaa?aca?act?ttt?gac?caa?atc?gac?agt?tcc?gcg?ctt?ggc 1507

Ala?Ala?Val?Glu?Thr?Thr?Phe?Asp?Gln?Ile?Asp?Ser?Ser?Ala?Leu?Gly

455 460 465

acg?cat?ctt?tat?atc?caa?gcg?ttc?agc?cca?aac?cgg?gca?gag?ata?gag 1555

Thr?His?Leu?Tyr?Ile?Gln?Ala?Phe?Ser?Pro?Asn?Arg?Ala?Glu?Ile?Glu

470 475 480 485

ctc?acc?aat?aga?gat?acg?tca?tat?gcg?gac?gac?aac?ggg?ctc?aaa?act 1603

Leu?Thr?Asn?Arg?Asp?Thr?Ser?Tyr?Ala?Asp?Asp?Asn?Gly?Leu?Lys?Thr

490 495 500

ttt?gga?ttc?ttc?acc?cca?gtg?agt?gca?gca?aat?ttg?ttc?gag?aaa?agt 1651

Phe?Gly?Phe?Phe?Thr?Pro?Val?Ser?Ala?Ala?Asn?Leu?Phe?Glu?Lys?Ser

505 510 515

tct?caa?ggc?ata?tcg?cta?agg?agc?cca?tgg?caa?ggt?ggc?acc?caa?tac 1699

Ser?Gln?Gly?Ile?Ser?Leu?Arg?Ser?Pro?Trp?Gln?Gly?Gly?Thr?Gln?Tyr

520 525 530

ctc?gca?gtg?aca?tac?cta?cca?agt?ggt?caa?gat?gaa?gat?gta?tcc?gca 1747

Leu?Ala?Val?Thr?Tyr?Leu?Pro?Ser?Gly?Gln?Asp?Glu?Asp?Val?Ser?Ala

535 540 545

act?gat?cag?ctg?ccc?aca?ttg?gaa?tat?gaa?ctc?gtg?gca?gaa?gcg?ttt 1795

Thr?Asp?Gln?Leu?Pro?Thr?Leu?Glu?Tyr?Glu?Leu?Val?Ala?Glu?Ala?Phe

550 555 560 565

gga?gac?cct?gtt?gac?cca?ccg?gtt?ttc?gct?tca?ttg?acg?gga?gca?acc 1843

Gly?Asp?Pro?Val?Asp?Pro?Pro?Val?Phe?Ala?Ser?Leu?Thr?Gly?Ala?Thr

570 575 580

cca?agc?acc?tcc?acc?ccc?cca?tca?gat?gtt?gcg?gaa?gat?gaa?caa?atc 1891

Pro?Ser?Thr?Ser?Thr?Pro?Pro?Ser?Asp?Val?Ala?Glu?Asp?Glu?Gln?Ile

585 590 595

tcc?gag?gca?aca?gaa?gaa?gac?tca?agc?agt?ttc?ccc?atc?gtg?tgg?att 1939

Ser?Glu?Ala?Thr?Glu?Glu?Asp?Ser?Ser?Ser?Phe?Pro?Ile?Val?Trp?Ile

600 605 610

ggg?ctg?ggt?gtc?att?ggc?tta?ggc?ata?atc?att?ggt?ttg?atc?ttt?gcg 1987

Gly?Leu?Gly?Val?Ile?Gly?Leu?Gly?Ile?Ile?Ile?Gly?Leu?Ile?Phe?Ala

615 620 625

ctg?aga?aga?aag?aat?taagccctaa?aagataaaga?gtc 2025

Leu?Arg?Arg?Lys?Asn

630

<210>272

<21l>634

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>272

Val?Ser?Gln?Pro?Leu?Ser?Lys?Arg?Leu?Ser?Ile?Arg?Lys?Ala?Leu?Ala

1 5 10 15

Ser?Ala?Phe?Ile?Val?Ala?Leu?Ala?Phe?Ser?Leu?Ser?Pro?Val?Ala?Lys

20 25 30

Ala?Gln?Ala?Asn?Glu?Thr?Pro?Thr?Met?Ile?Val?Leu?Asp?Asn?Ser?Gly

35 40 45

Ser?Met?Thr?Ala?Gln?Asp?Ala?Gly?Gly?Gln?Thr?Arg?Ile?Asp?Ala?Ala

50 55 60

Lys?Gln?Ala?Ser?Thr?Gln?Leu?Ile?Asn?Asp?Ile?Ser?Asp?Arg?Thr?Asp

65 70 75 80

Val?Gly?Leu?Thr?Tyr?Tyr?Gly?Gly?Asn?Thr?Gly?Glu?Thr?Glu?Ala?Asp

85 90 95

Val?Glu?Met?Gly?Cys?Gln?Asp?Val?Thr?Ile?Leu?Gly?Gly?Pro?Ser?Arg

100 105 110

Gly?Asn?Ala?Asp?Thr?Leu?Ile?Asp?Thr?Ile?Asn?Ser?Leu?Gln?Pro?Arg

115 120 125

Gly?Phe?Thr?Pro?Ile?Gly?Lys?Ala?Leu?Thr?Asp?Thr?Ala?Ala?Glu?Leu

130 135 140

Pro?Glu?Gly?Gly?Asn?Ile?Val?Leu?Val?Ser?Asp?Gly?Ile?Ala?Asn?Cys

145 150 155 160

Thr?Pro?Pro?Asp?Val?Cys?Glu?Val?Ala?Gln?Glu?Leu?Ala?Gln?Ser?Gly

165 170 175

Ile?Asn?Leu?Val?Ile?Asn?Thr?Ile?Gly?Leu?Asn?Val?Asp?Pro?Ala?Ala

180 185 190

Arg?Glu?Glu?Leu?Glu?Cys?Ile?Ala?Gly?Val?Gly?Gly?Gly?Thr?Tyr?Ala

195 200 205

Asp?Ala?Ser?Asp?Ala?Gln?Ser?Leu?Thr?Asp?Ala?Leu?Thr?Arg?Ala?Ala

210 215 220

Ser?Arg?Gln?Tyr?Asn?Ser?Tyr?Thr?Ser?Asp?Val?Thr?Lys?Ile?Asp?Gly

225 230 235 240

Ala?Ser?Glu?Gln?Ser?Ala?Ala?Val?Glu?Ile?Asp?Glu?Asp?Thr?Glu?Leu

245 250 255

Phe?Leu?Thr?Asp?Leu?Pro?Gln?Glu?Ser?Arg?Phe?Trp?Lys?Ile?Pro?Val

260 265 270

Glu?Pro?Gly?Glu?Thr?Ile?Ser?Val?Ser?Ala?Asn?Thr?Val?Thr?Asp?Pro

275 280 285

Thr?Val?Leu?Thr?Met?Gly?Gln?Gly?Gly?Ile?Lys?Leu?Glu?Ala?Gln?Leu

290 295 300

His?Thr?Glu?Glu?Ala?Pro?Gln?Tyr?Gly?Leu?Arg?Gly?Arg?Cys?Thr?Arg

305 310 315 320

Val?Ser?Phe?Asp?Asn?Phe?Lys?Pro?Gly?Leu?Gly?Val?Arg?Gly?Ile?Gln

325 330 335

Asn?Ala?Ser?Val?Ala?Ser?Lys?Glu?Val?Gly?Thr?Asn?Asn?Cys?Asp?Thr

340 345 350

Asp?Ala?Ile?Tyr?Leu?Glu?Ile?Ser?Arg?Ser?Gly?Asp?Tyr?Leu?Asn?Gly

355 360 365

Gln?Asp?Ile?Pro?Thr?Glu?Ile?Thr?Ile?Glu?Arg?Phe?Gly?Lys?Val?Asp

370 375 380

Glu?Ser?Thr?Ile?Gly?Asn?Val?Thr?Glu?Glu?His?Ser?Ser?Val?Asp?Leu

385 390 395 400

Thr?Glu?Ala?Ala?Ala?Ser?Glu?Ala?His?Pro?Val?Thr?Pro?Gly?Gln?Trp

405 410 415

Phe?Thr?Ser?Ala?Ala?Asp?Leu?Asp?Pro?Ala?Gly?Glu?Lys?Val?Ser?Ser

420 425 430

Ile?Ile?Val?Pro?Gly?Glu?Thr?His?Phe?Tyr?Ala?Leu?Pro?Val?Asp?Tyr

435 440 445

Gly?Gln?Glu?Leu?Arg?Ala?Ala?Val?Glu?Thr?Thr?Phe?Asp?Gln?Ile?Asp

450 455 460

Ser?Ser?Ala?Leu?Gly?Thr?His?Leu?Tyr?Ile?Gln?Ala?Phe?Ser?Pro?Asn

465 470 475 480

Arg?Ala?Glu?Ile?Glu?Leu?Thr?Asn?Arg?Asp?Thr?Ser?Tyr?Ala?Asp?Asp

485 490 495

Asn?Gly?Leu?Lys?Thr?Phe?Gly?Phe?Phe?Thr?Pro?Val?Ser?Ala?Ala?Asn

500 505 510

Leu?Phe?Glu?Lys?Ser?Ser?Gln?Gly?Ile?Ser?Leu?Arg?Ser?Pro?Trp?Gln

515 520 525

Gly?Gly?Thr?Gln?Tyr?Leu?Ala?Val?Thr?Tyr?Leu?Pro?Ser?Gly?Gln?Asp

530 535 540

Glu?Asp?Val?Ser?Ala?Thr?Asp?Gln?Leu?Pro?Thr?Leu?Glu?Tyr?Glu?Leu

545 550 555 560

Val?Ala?Glu?Ala?Phe?Gly?Asp?Pro?Val?Asp?Pro?Pro?Val?Phe?Ala?Ser

565 570 575

Leu?Thr?Gly?Ala?Thr?Pro?Ser?Thr?Ser?Thr?Pro?Pro?Ser?Asp?Val?Ala

580 585 590

Glu?Asp?Glu?Gln?Ile?Ser?Glu?Ala?Thr?Glu?Glu?Asp?Ser?Ser?Ser?Phe

595 600 605

Pro?Ile?Val?Trp?Ile?Gly?Leu?Gly?Val?Ile?Gly?Leu?Gly?Ile?Ile?Ile

610 615 620

Gly?Leu?Ile?Phe?Ala?Leu?Arg?Arg?Lys?Asn

625 630

<210>273

<211>576

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(553)

<223>RXN01302

<400>273

tggggctgcg?tggtgttctt?catcatcgcc?accgctttga?cctggatcta?ctacgcccgc 60

ccgaacgctc?cattcccggg?ataaaccgaa?aggccaatcc?atg?act?aca?act?act 115

Met?Thr?Thr?Thr?Thr

1 5

tct?tct?ggg?aag?tct?tct?gaa?aag?atc?aac?ccc?ctc?ttc?aag?ctc?ggc 163

Ser?Ser?Gly?Lys?Ser?Ser?Glu?Lys?Ile?Asn?Pro?Leu?Phe?Lys?Leu?Gly

10 15 20

agt?ttc?cta?aga?aaa?ggc?acc?gtc?ggt?tct?gaa?ggc?cag?cag?att?ttc 211

Ser?Phe?Leu?Arg?Lys?Gly?Thr?Val?Gly?Ser?Glu?Gly?Gln?Gln?Ile?Phe

25 30 35

ctt?cag?ggc?gga?cgc?caa?gcc?gat?gtg?ttt?tat?cgc?aac?cga?tgg?gct 259

Leu?Gln?Gly?Gly?Arg?Gln?Ala?Asp?Val?Phe?Tyr?Arg?Asn?Arg?Trp?Ala

40 45 50

ttc?gat?aaa?gtc?gtg?cgc?tcc?aca?cat?ggc?gtg?aac?tgc?acg?ggc?tcc 307

Phe?Asp?Lys?Val?Val?Arg?Ser?Thr?His?Gly?Val?Asn?Cys?Thr?Gly?Ser

55 60 65

tgc?tcg?tgg?aaa?gtg?tat?gta?aaa?gac?ggt?gtg?atc?acc?tgg?gaa?tcc 355

Cys?Ser?Trp?Lys?Val?Tyr?Val?Lys?Asp?Gly?Val?Ile?Thr?Trp?Glu?Ser

70 75 80 85

cag?gca?gtg?gat?tac?cca?act?acc?ggt?gcg?gat?atg?ccc?gac?aat?gaa 403

Gln?Ala?Val?Asp?Tyr?Pro?Thr?Thr?Gly?Ala?Asp?Met?Pro?Asp?Asn?Glu

90 95 100

cca?cgt?ggc?tgc?cct?cgt?ggt?gca?tca?ttt?tcc?tgg?tac?acc?tac?tcc 451

Pro?Arg?Gly?Cys?Pro?Arg?Gly?Ala?Ser?Phe?Ser?Trp?Tyr?Thr?Tyr?Ser

105 110 115

cca?acc?cgc?atc?cgc?tac?cca?tac?atc?ggt?ggc?gtg?cta?gtt?gat?atg 499

Pro?Thr?Arg?Ile?Arg?Tyr?Pro?Tyr?Ile?Gly?Gly?Val?Leu?Val?Asp?Met

120 125 130

tcc?gcg?aag?cca?agg?aac?gcc?tgg?gcg?atc?cgg?tgc?tgg?cgt?ggc?gcg 547

Ser?Ala?Lys?Pro?Arg?Asn?Ala?Trp?Ala?Ile?Arg?Cys?Trp?Arg?Gly?Ala

135 140 145

aca?ttg?tagaaacccc?agaaaagcgc?aaa 576

Thr?Leu

150

<210>274

<211>151

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>274

Met?Thr?Thr?Thr?Thr?Ser?Ser?Gly?Lys?Ser?Ser?Glu?Lys?Ile?Asn?Pro

1 5 10 15

Leu?Phe?Lys?Leu?Gly?Ser?Phe?Leu?Arg?Lys?Gly?Thr?Val?Gly?Ser?Glu

20 25 30

Gly?Gln?Gln?Ile?Phe?Leu?Gln?Gly?Gly?Arg?Gln?Ala?Asp?Val?Phe?Tyr

35 40 45

Arg?Asn?Arg?Trp?Ala?Phe?Asp?Lys?Val?Val?Arg?Ser?Thr?His?Gly?Val

50 55 60

Asn?Cys?Tnr?Gly?Ser?Cys?Ser?Trp?Lys?Val?Tyr?Val?Lys?Asp?Gly?Val

65 70 75 80

Ile?Thr?Trp?Glu?Ser?Gln?Ala?Val?Asp?Tyr?Pro?Thr?Thr?Gly?Ala?Asp

85 90 95

Met?Pro?Asp?Asn?Glu?Pro?Arg?Gly?Cys?Pro?Arg?Gly?Ala?Ser?Phe?Ser

100 105 110

Trp?Tyr?Thr?Tyr?Ser?Pro?Thr?Arg?Ile?Arg?Tyr?Pro?Tyr?Ile?Gly?Gly

115 120 125

Val?Leu?Val?Asp?Met?Ser?Ala?Lys?Pro?Arg?Asn?Ala?Trp?Ala?Ile?Arg

130 135 140

Cys?Trp?Arg?Gly?Ala?Thr?Leu

145 150

<210>275

<211>466

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(466)

<223>FRXA01302

<400>275

tggggctgcg?tggtgttctt?catcatcgcc?accgctttga?cctggatcta?ctacgcccgc 60

ccgaacgctc?cattcccggg?ataaaccgaa?aggccaatcc?atg?act?aca?act?act 115

Met?Thr?Thr?Thr?Thr

1 5

tct?tct?ggg?aag?tct?tct?gaa?aag?atc?aac?ccc?ctc?ttc?aag?ctc?ggc 163

Ser?Ser?Gly?Lys?Ser?Ser?Glu?Lys?Ile?Asn?Pro?Leu?Phe?Lys?Leu?Gly

10 15 20

agt?ttc?cta?aga?aaa?ggc?acc?gtc?ggt?tct?gaa?ggc?cag?cag?att?ttc 211

Ser?Phe?Leu?Arg?Lys?Gly?Thr?Val?Gly?Ser?Glu?Gly?Gln?Gln?Ile?Phe

25 30 35

ctt?cag?ggc?gga?cgc?caa?gcc?gat?gtg?ttt?tat?cgc?aac?cga?tgg?gct 259

Leu?Gln?Gly?Gly?Arg?Gln?Ala?Asp?Val?Phe?Tyr?Arg?Asn?Arg?Trp?Ala

40 45 50

ttc?gat?aaa?gtc?gtg?cgc?tcc?aca?cat?ggc?gtg?aac?tgc?acg?ggc?tcc 307

Phe?Asp?Lys?Val?Val?Arg?Ser?Thr?His?Gly?Val?Asn?Cys?Thr?Gly?Ser

55 60 65

tgc?tcg?tgg?aaa?gtg?tat?gta?aaa?gac?ggt?gtg?atc?acc?tgg?gaa?tcc 355

Cys?Ser?Trp?Lys?Val?Tyr?Val?Lys?Asp?Gly?Val?Ile?Thr?Trp?Glu?Ser

70 75 80 85

cag?gca?gtg?gat?tac?cca?act?acc?ggt?gcg?gat?atg?ccc?gac?aat?gaa 403

Gln?Ala?Val?Asp?Tyr?Pro?Thr?Thr?Gly?Ala?Asp?Met?Pro?Asp?Asn?Glu

90 95 100

cca?cgt?ggc?tgc?cct?cgt?ggt?gca?tca?ttt?tcc?tgg?tac?acc?tac?tcc 451

Pro?Arg?Gly?Cys?Pro?Arg?Gly?Ala?Ser?Phe?Ser?Trp?Tyr?Thr?Tyr?Ser

105 110 115

cca?acc?ggc?atc?cgc 466

Pro?Thr?Gly?Ile?Arg

120

<210>276

<211>122

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>276

Met?Thr?Thr?Thr?Thr?Ser?Ser?Gly?Lys?Ser?Ser?Glu?Lys?Ile?Asn?Pro

1 5 10 15

Leu?Phe?Lys?Leu?Gly?Ser?Phe?Leu?Arg?Lys?Gly?Thr?Val?Gly?Ser?Glu

20 25 30

Gly?Gln?Gln?Ile?Phe?Leu?Gln?Gly?Gly?Arg?Gln?Ala?Asp?Val?Phe?Tyr

35 40 45

Arg?Asn?Arg?Trp?Ala?Phe?Asp?Lys?Val?Val?Arg?Ser?Thr?His?Gly?Val

50 55 60

Asn?Cys?Thr?Gly?Ser?Cys?Ser?Trp?Lys?Val?Tyr?Val?Lys?Asp?Gly?Val

65 70 75 80

Ile?Thr?Trp?Glu?Ser?Gln?Ala?Val?Asp?Tyr?Pro?Thr?Thr?Gly?Ala?Asp

85 90 95

Met?Pro?Asp?Asn?Glu?Pro?Arg?Gly?Cys?Pro?Arg?Gly?Ala?Ser?Phe?Ser

100 105 110

Trp?Tyr?Thr?Tyr?Ser?Pro?Thr?Gly?Ile?Arg

115 120

<210>277

<211>2503

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(2503)

<223>RXN01308

<400>277

tttcctggta?cacctactcc?ccaacccgca?tccgctaccc?atacatcggt?ggcgtgctag 60

ttgatatgtc?cgcgaagcca?aggaacgcct?gggcgatccg?gtg?ctg?gcg?tgg?cgc 115

Val?Leu?Ala?Trp?Arg

1 5

gac?att?gta?gaa?acc?cca?gaa?aag?cgc?aaa?gca?tat?gta?tcc?cag?cgg 163

Asp?Ile?Val?Glu?Thr?Pro?Glu?Lys?Arg?Lys?Ala?Tyr?Val?Ser?Gln?Arg

10 15 20

ggc?aaa?ggt?ggc?ctc?atc?cgc?gtt?cag?tat?gag?gaa?gcc?atg?gag?att 211

Gly?Lys?Gly?Gly?Leu?Ile?Arg?Val?Gln?Tyr?Glu?Glu?Ala?Met?Glu?Ile

25 30 35

gct?gcg?gca?gcc?cat?gtg?tac?acc?atc?cgc?caa?tac?ggc?ccc?gac?cgc 259

Ala?Ala?Ala?Ala?His?Val?Tyr?Thr?Ile?Arg?Gln?Tyr?Gly?Pro?Asp?Arg

40 45 50

att?cat?gga?ttc?acc?gtt?att?ccc?gca?atg?tcg?cag?gtg?tct?tac?ggt 307

Ile?His?Gly?Phe?Thr?Val?Ile?Pro?Ala?Met?Ser?Gln?Val?Ser?Tyr?Gly

55 60 65

gct?ggt?act?cgc?ttc?ttg?cag?atg?atc?ggc?gga?gtg?gcg?ctg?tcc?ttc 355

Ala?Gly?Thr?Arg?Phe?Leu?Gln?Met?Ile?Gly?Gly?Val?Ala?Leu?Ser?Phe

70 75 80 85

tac?gat?tgg?tac?gcc?gac?ctc?cca?cca?gca?tca?cca?caa?act?ttc?ggc 403

Tyr?Asp?Trp?Tyr?Ala?Asp?Leu?Pro?Pro?Ala?Ser?Pro?Gln?Thr?Phe?Gly

90 95 100

gat?caa?act?gac?gtt?ccg?gaa?tct?ggc?gac?tgg?tac?aac?tcc?agc?tac 451

Asp?Gln?Thr?Asp?Val?Pro?Glu?Ser?Gly?Asp?Trp?Tyr?Asn?Ser?Ser?Tyr

105 110 115

ctc?atg?atg?tgg?ggt?tcc?aac?att?ccg?gtg?acc?cgc?acg?cct?gac?tcc 499

Leu?Met?Met?Trp?Gly?Ser?Asn?Ile?Pro?Val?Thr?Arg?Thr?Pro?Asp?Ser

120 125 130

cacttc?atg?gtg?gaa?gcc?cgc?tac?aag?ggc?acc?aag?gtt?gtt?gtg?gtt 547

His?Phe?Met?Val?Glu?Ala?Arg?Tyr?Lys?Gly?Thr?Lys?Val?Val?Val?Val

135 140 145

tcc?ccg?gat?ttc?gct?gac?tcc?acc?aaa?ttt?gct?gat?gaa?tgg?gca?cgc 595

Ser?Pro?Asp?Phe?Ala?Asp?Ser?Thr?Lys?Phe?Ala?Asp?Glu?Trp?Ala?Arg

150 155 160 165

atc?cac?cct?ggt?act?gac?ggc?gca?ctc?gcc?ttt?gcc?atg?ggc?cat?gtg 643

Ile?His?Pro?Gly?Thr?Asp?Gly?Ala?Leu?Ala?Phe?Ala?Met?Gly?His?Val

170 175 180

atc?ttg?aag?gaa?ttc?cat?gtt?gac?aag?aag?acg?ccg?tacttc?atg?gac 69l

Ile?Leu?Lys?Glu?Phe?His?Val?Asp?Lys?Lys?Thr?Pro?Tyr?Phe?Met?Asp

185 190 195

tac?atg?cgc?aaa?tac?acg?gac?tct?cct?ttc?ctc?gtg?gaa?tta?gat?gag 739

Tyr?Met?Arg?Lys?Tyr?Thr?Asp?Ser?Pro?Phe?Leu?Val?Glu?Leu?Asp?Glu

200 205 210

cac?ggc?gat?ggc?acc?tac?acc?cca?ggt?aaa?ttc?ctc?act?gca?gac?cgc 787

His?Gly?Asp?Gly?Thr?Tyr?Thr?Pro?Gly?Lys?Phe?Leu?Thr?Ala?Asp?Arg

215 220 225

gca?gct?gat?atc?tcc?cca?gcg?ctt?gcc?gcc?act?cca?aat?gcc?acc?cac 835

Ala?Ala?Asp?Ile?Ser?Pro?Ala?Leu?Ala?Ala?Thr?Pro?Asn?Ala?Thr?His

230 235 240 245

cgt?ctc?ctt?gtg?ctg?caa?aaa?gat?ggc?tca?gtt?gta?gat?ccc?ggt?ggc 883

Arg?Leu?Leu?Val?Leu?Gln?Lys?Asp?Gly?Ser?Val?Val?Asp?Pro?Gly?Gly

250 255 260

act?gtc?gcg?gac?cgt?tgg?ggt?gaa?gaa?ggc?atg?ggt?aag?tgg?aat?ctg 931

Thr?Val?Ala?Asp?Arg?Trp?Gly?Glu?Glu?Gly?Met?Gly?Lys?Trp?Asn?Leu

265 270 275

cgc?tta?gac?ggc?gta?gat?cca?gtg?atg?act?att?gca?gat?gta?cag?act 979

Arg?Leu?Asp?Gly?Val?Asp?Pro?Val?Met?Thr?Ile?Ala?Asp?Val?Gln?Thr

280 285 290

gac?acc?gaa?act?gcg?gaa?gtc?ctc?ttc?ccc?cgc?ttc?gat?ctc?cca?gca 1027

Asp?Thr?Glu?Thr?Ala?Glu?Val?Leu?Phe?Pro?Arg?Phe?Asp?Leu?Pro?Ala

295 300 305

act?gcc?acc?caa?gaa?ggc?ccc?att?ggt?gct?ggc?acc?atc?agc?cgg?ggc 1075

Thr?Ala?Thr?Gln?Glu?Gly?Pro?Ile?Gly?Ala?Gly?Thr?Ile?Ser?Arg?Gly

310 315 320 325

gtt?ccc?acc?atc?acg?ttg?aat?ggc?cga?aag?tac?acc?act?gtc?ttt?gat 1123

Val?Pro?Thr?Ile?Thr?Leu?Asn?Gly?Arg?Lys?Tyr?Thr?Thr?Val?Phe?Asp

330 335 340

gtg?ttg?ctc?gca?cac?tac?ggt?gtg?aac?cgc?gaa?gag?ctc?aac?ctt?cct 1171

Val?Leu?Leu?Ala?His?Tyr?Gly?Val?Asn?Arg?Glu?Glu?Leu?Asn?Leu?Pro

345 350 355

ggt?gag?tgg?cct?aag?gat?ttc?cag?gat?cca?gtc?atg?ggt?act?cct?gcg 1219

Gly?Glu?Trp?Pro?Lys?Asp?Phe?Gln?Asp?Pro?Val?Met?Gly?Thr?Pro?Ala

360 365 370

tgg?cag?gaa?gag?ctc?acg?ggt?gtt?cct?gct?aat?cag?gcg?att?cgt?ttg 1267

Trp?Gln?Glu?Glu?Leu?Thr?Gly?Val?Pro?Ala?Asn?Gln?Ala?Ile?Arg?Leu

375 380 385

ggt?cgg?gaa?ttt?gct?cag?aat?gct?gat?gat?tcc?aag?ggc?cgt?tcc?cag 1315

Gly?Arg?Glu?Phe?Ala?Gln?Asn?Ala?Asp?Asp?Ser?Lys?Gly?Arg?Ser?Gln

390 395 400 405

atc?atc?atg?ggt?gct?ggt?gtg?aac?cac?tacttc?cat?gcg?gat?tct?att 1363

Ile?Ile?Met?Gly?Ala?Gly?Val?Asn?His?Tyr?Phe?His?Ala?Asp?Ser?Ile

410 415 420

tat?cgc?aca?ttc?ttg?gcg?ctg?acc?tct?atg?tgt?ggc?acc?caa?ggt?gtt 1411

Tyr?Arg?Thr?Phe?Leu?Ala?Leu?Thr?Ser?Met?Cys?Gly?Thr?Gln?Gly?Val

425 430 435

aac?ggt?ggc?ggt?tgg?gct?cac?tac?gtt?ggt?cag?gag?aaa?ctc?cgt?cca 1459

Asn?Gly?Gly?Gly?Trp?Ala?His?Tyr?Val?Gly?Gln?Glu?Lys?Leu?Arg?Pro

440 445 450

atg?aat?ggt?tgg?gca?cag?tat?gcc?ttt?gct?aca?gac?tgg?cag?cgt?cca 1507

Met?Asn?Gly?Trp?Ala?Gln?Tyr?Ala?Phe?Ala?Thr?Asp?Trp?Gln?Arg?Pro

455 460 465

cca?cgt?cag?atg?atc?acc?act?ggt?ttc?tac?tac?ctc?acc?acg?gat?cag 1555

Pro?Arg?Gln?Met?Ile?Thr?Thr?Gly?Phe?Tyr?Tyr?Leu?Thr?Thr?Asp?Gln

470 475 480 485

tgg?agg?tat?gac?aac?act?cgt?gct?aat?cgt?ctg?gct?tcc?cca?ctg?gct 1603

Trp?Arg?Tyr?Asp?Asn?Thr?Arg?Ala?Asn?Arg?Leu?Ala?Ser?Pro?Leu?Ala

490 495 500

aat?cgt?ggc?acc?gtg?ggt?gac?aaa?atg?acg?gcg?gat?acc?ttg?gtg?gaa 1651

Asn?Arg?Gly?Thr?Val?Gly?Asp?Lys?Met?Thr?Ala?Asp?Thr?Leu?Val?Glu

505 510 515

tcc?atg?aaa?cgt?gga?tgg?atg?ccg?tca?ttc?ccg?caa?ttc?aac?cgc?aat 1699

Ser?Met?Lys?Arg?Gly?Trp?Met?Pro?Ser?Phe?Pro?Gln?Phe?Asn?Arg?Asn

520 525 530

ccc?ctc?atc?ttg?agc?cag?gag?gcg?gaa?gaa?aag?ggc?gtg?tct?gtt?tct 1747

Pro?Leu?Ile?Leu?Ser?Gln?Glu?Ala?Glu?Glu?Lys?Gly?Val?Ser?Val?Ser

535 540 545

gac?cat?att?gtt?cag?cag?ctc?acc?gat?ggt?gac?ttg?cag?ttc?gcc?tgc 1795

Asp?His?Ile?Val?Gln?Gln?Leu?Thr?Asp?Gly?Asp?Leu?Gln?Phe?Ala?Cys

550 555 560 565

gag?gat?ccg?gat?gca?ccg?gaa?aac?tgg?cca?cgc?att?ctg?ctt?aac?tgg 1843

Glu?Asp?Pro?Asp?Ala?Pro?Glu?Asn?Trp?Pro?Arg?Ile?Leu?Leu?Asn?Trp

570 575 580

cgc?aca?aac?cta?atg?ggc?tct?tca?gct?aag?ggc?acg?gag?ttt?ttc?ttg 1891

Arg?Thr?Asn?Leu?Met?Gly?Ser?Ser?Ala?Lys?Gly?Thr?Glu?Phe?Phe?Leu

585 590 595

cgc?cat?atg?ttg?ggt?gtg?gat?tct?gat?gca?tct?gct?gaa?gaa?aac?gcg 1939

Arg?His?Met?Leu?Gly?Val?Asp?Ser?Asp?Ala?Ser?Ala?Glu?Glu?Asn?Ala

600 605 610

ccg?gag?gat?cgt?cca?agt?tcc?att?gtg?tgg?agg?gat?gag?gct?ccg?gaa 1987

Pro?Glu?Asp?Arg?Pro?Ser?Ser?Ile?Val?Trp?Arg?Asp?Glu?Ala?Pro?Glu

615 620 625

gga?aag?ctc?gat?ttg?atg?ctg?acc?acg?gat?ttc?cgc?aac?act?tcc?acc 2035

Gly?Lys?Leu?Asp?Leu?Met?Leu?Thr?Thr?Asp?Phe?Arg?Asn?Thr?Ser?Thr

630 635 640 645

acc?ttg?gtc?tcg?gat?atc?gtg?ctg?ccg?gca?gcc?acc?tgg?tat?gag?aag 2083

Thr?Leu?Val?Ser?Asp?Ile?Val?Leu?Pro?Ala?Ala?Thr?Trp?Tyr?Glu?Lys

650 655 660

cat?gat?ttg?tcc?acc?acg?gat?atg?cac?ccc?ttc?atc?cac?tcg?ttc?aat 2131

His?Asp?Leu?Ser?Thr?Thr?Asp?Met?His?Pro?Phe?Ile?His?Ser?Phe?Asn

665 670 675

gct?gcg?atc?aac?cca?ccg?tgg?gag?acg?cgt?act?gac?tgg?gag?gtc?ttc 2179

Ala?Ala?Ile?Asn?Pro?Pro?Trp?Glu?Thr?Arg?Thr?Asp?Trp?Glu?Val?Phe

680 685 690

cac?gat?ctc?acc?aaa?gaa?ttc?tcc?tca?cag?gca?gca?acc?tgg?ttg?ggc 2227

His?Asp?Leu?Thr?Lys?Glu?Phe?Ser?Ser?Gln?Ala?Ala?Thr?Trp?Leu?Gly

695 700 705

acc?caa?acc?gat?gtg?atc?acc?gca?ccg?att?gcc?cat?gac?tcc?ccg?gat 2275

Thr?Gln?Thr?Asp?Val?Ile?Thr?Ala?Pro?Ile?Ala?His?Asp?Ser?Pro?Asp

710 715 720 725

gag?ctc?aat?atg?cct?ggc?ggt?atc?gtg?cca?gat?att?gat?gag?gtc?ggg 2323

Glu?Leu?Asn?Met?Pro?Gly?Gly?Ile?Val?Pro?Asp?Ile?Asp?Glu?Val?Gly

730 735 740

ctg?atc?cct?ggc?aag?acg?atg?gcc?aag?atc?atc?ccg?gtg?gaa?cgt?gat 2371

Leu?Ile?Pro?Gly?Lys?Thr?Met?Ala?Lys?Ile?Ile?Pro?Val?Glu?Arg?Asp

745 750 755

tac?tcc?aag?gtg?tat?gaa?aag?tgg?aca?cac?ttg?gga?cca?ctc?acc?gcc 2419

Tyr?Ser?Lys?Val?Tyr?Glu?Lys?Trp?Thr?His?Leu?Gly?Pro?Leu?Thr?Ala

760 765 770

aaa?gcg?ggt?acc?gga?acc?cac?ggc?act?gcg?ttt?aac?gtg?acc?aag?caa 2467

Lys?Ala?Gly?Thr?Gly?Thr?His?Gly?Thr?Ala?Phe?Asn?Val?Thr?Lys?Gln

775 780 785

acc?gag?gag?ctg?gcg?ctg?atc?aac?ggc?acc?tcc?atc 2503

Thr?Glu?Glu?Leu?Ala?Leu?Ile?Asn?Gly?Thr?Ser?Ile

790 795 800

<210>278

<211>801

<212>PRT

＜213〉Corynebacterium glutamicum (C0rynebacterium glutamicum)

<400>278

Val?Leu?Ala?Trp?Arg?Asp?Ile?Val?Glu?Thr?Pro?Glu?Lys?Arg?Lys?Ala

1 5 10 15

Tyr?Val?Ser?Gln?Arg?Gly?Lys?Gly?Gly?Leu?Ile?Arg?Val?Gln?Tyr?Glu

20 25 30

Glu?Ala?Met?Glu?Ile?Ala?Ala?Ala?Ala?His?Val?Tyr?Thr?Ile?Arg?Gln

35 40 45

Tyr?Gly?Pro?Asp?Arg?Ile?His?Gly?Phe?Thr?Val?Ile?Pro?Ala?Met?Ser

50 55 60

Gln?Val?Ser?Tyr?Gly?Ala?Gly?Thr?Arg?Phe?Leu?Gln?Met?Ile?Gly?Gly

65 70 75 80

Val?Ala?Leu?Ser?Phe?Tyr?Asp?Trp?Tyr?Ala?Asp?Leu?Pro?Pro?Ala?Ser

85 90 95

Pro?Gln?Thr?Phe?Gly?Asp?Gln?Thr?Asp?Val?Pro?Glu?Ser?Gly?Asp?Trp

100 105 110

Tyr?Asn?Ser?Ser?Tyr?Leu?Met?Met?Trp?Gly?Ser?Asn?Ile?Pro?Val?Thr

115 120 125

Arg?Thr?Pro?Asp?Ser?His?Phe?Met?Val?Glu?Ala?Arg?Tyr?Lys?Gly?Thr

130 135 140

Lys?Val?Val?Val?Val?Ser?Pro?Asp?Phe?Ala?Asp?Ser?Thr?Lys?Phe?Ala

145 150 155 160

Asp?Glu?Trp?Ala?Arg?Ile?His?Pro?Gly?Thr?Asp?Gly?Ala?Leu?Ala?Phe

165 170 175

Ala?Met?Gly?His?Val?Ile?Leu?Lys?Glu?Phe?His?Val?Asp?Lys?Lys?Thr

180 185 190

Pro?Tyr?Phe?Met?Asp?Tyr?Met?Arg?Lys?Tyr?Thr?Asp?Ser?Pro?Phe?Leu

195 200 205

Val?Glu?Leu?Asp?Glu?His?Gly?Asp?Gly?Thr?Tyr?Thr?Pro?Gly?Lys?Phe

210 215 220

Leu?Thr?Ala?Asp?Arg?Ala?Ala?Asp?Ile?Ser?Pro?Ala?Leu?Ala?Ala?Thr

225 230 235 240

Pro?Asn?Ala?Thr?His?Arg?Leu?Leu?Val?Leu?Gln?Lys?Asp?Gly?Ser?Val

245 250 255

Val?Asp?Pro?Gly?Gly?Thr?Val?Ala?Asp?Arg?Trp?Gly?Glu?Glu?Gly?Met

260 265 270

Gly?Lys?Trp?Asn?Leu?Arg?Leu?Asp?Gly?Val?Asp?Pro?Val?Met?Thr?Ile

275 280 285

Ala?Asp?Val?Gln?Thr?Asp?Thr?Glu?Thr?Ala?Glu?Val?Leu?Phe?Pro?Arg

290 295 300

Phe?Asp?Leu?Pro?Ala?Thr?Ala?Thr?Gln?Glu?Gly?Pro?Ile?Gly?Ala?Gly

305 310 315 320

Thr?Ile?Ser?Arg?Gly?Val?Pro?Thr?Ile?Thr?Leu?Asn?Gly?Arg?Lys?Tyr

325 330 335

Thr?Thr?Val?Phe?Asp?Val?Leu?Leu?Ala?His?Tyr?Gly?Val?Asn?Arg?Glu

340 345 350

Glu?Leu?Asn?Leu?Pro?Gly?Glu?Trp?Pro?Lys?Asp?Phe?Gln?Asp?Pro?Val

355 360 365

Met?Gly?Thr?Pro?Ala?Trp?Gln?Glu?Glu?Leu?Thr?Gly?Val?Pro?Ala?Asn

370 375 380

Gln?Ala?Ile?Arg?Leu?Gly?Arg?Glu?Phe?Ala?Gln?Asn?Ala?Asp?Asp?Ser

385 390 395 400

Lys?Gly?Arg?Ser?Gln?Ile?Ile?Met?Gly?Ala?Gly?Val?Asn?His?Tyr?Phe

405 410 415

His?Ala?Asp?Ser?Ile?Tyr?Arg?Thr?Phe?Leu?Ala?Leu?Thr?Ser?Met?Cys

420 425 430

Gly?Thr?Gln?Gly?Val?Asn?Gly?Gly?Gly?Trp?Ala?His?Tyr?Val?Gly?Gln

435 440 445

Glu?Lys?Leu?Arg?Pro?Met?Asn?Gly?Trp?Ala?Gln?Tyr?Ala?Phe?Ala?Thr

450 455 460

Asp?Trp?Gln?Arg?Pro?Pro?Arg?Gln?Met?Ile?Thr?Thr?Gly?Phe?Tyr?Tyr

465 470 475 480

Leu?Thr?Thr?Asp?Gln?Trp?Arg?Tyr?Asp?Asn?Thr?Arg?Ala?Asn?Arg?Leu

485 490 495

Ala?Ser?Pro?Leu?Ala?Asn?Arg?Gly?Thr?Val?Gly?Asp?Lys?Met?Thr?Ala

500 505 510

Asp?Thr?Leu?Val?Glu?Ser?Met?Lys?Arg?Gly?Trp?Met?Pro?Ser?Phe?Pro

515 520 525

Gln?Phe?Asn?Arg?Asn?Pro?Leu?Ile?Leu?Ser?Gln?Glu?Ala?Glu?Glu?Lys

530 535 540

Gly?Val?Ser?Val?Ser?Asp?His?Ile?Val?Gln?Gln?Leu?Thr?Asp?Gly?Asp

545 550 555 560

Leu?Gln?Phe?Ala?Cys?Glu?Asp?Pro?Asp?Ala?Pro?Glu?Asn?Trp?Pro?Arg

565 570 575

Ile?Leu?Leu?Asn?Trp?Arg?Thr?Asn?Leu?Met?Gly?Ser?Ser?Ala?Lys?Gly

580 585 590

Thr?Glu?Phe?Phe?Leu?Arg?His?Met?Leu?Gly?Val?Asp?Ser?Asp?Ala?Ser

595 600 605

Ala?Glu?Glu?Asn?Ala?Pro?Glu?Asp?Arg?Pro?Ser?Ser?Ile?Val?Trp?Arg

610 615 620

Asp?Glu?Ala?Pro?Glu?Gly?Lys?Leu?Asp?Leu?Met?Leu?Thr?Thr?Asp?Phe

625 630 635 640

Arg?Asn?Thr?Ser?Thr?Thr?Leu?Val?Ser?Asp?Ile?Val?Leu?Pro?Ala?Ala

645 650 655

Thr?Trp?Tyr?Glu?Lys?His?Asp?Leu?Ser?Thr?Thr?Asp?Met?His?Pro?Phe

660 665 670

Ile?His?Ser?Phe?Asn?Ala?Ala?Ile?Asn?Pro?Pro?Trp?Glu?Thr?Arg?Thr

675 680 685

Asp?Trp?Glu?Val?Phe?His?Asp?Leu?Thr?Lys?Glu?Phe?Ser?Ser?Gln?Ala

690 695 700

Ala?Thr?Trp?Leu?Gly?Thr?Gln?Thr?Asp?Val?Ile?Thr?Ala?Pro?Ile?Ala

705 710 715 720

His?Asp?Ser?Pro?Asp?Glu?Leu?Asn?Met?Pro?Gly?Gly?Ile?Val?Pro?Asp

725 730 735

Ile?Asp?Glu?Val?Gly?Leu?Ile?Pro?Gly?Lys?Thr?Met?Ala?Lys?Ile?Ile

740 745 750

Pro?Val?Glu?Arg?Asp?Tyr?Ser?Lys?Val?Tyr?Glu?Lys?Trp?Thr?His?Leu

755 760 765

Gly?Pro?Leu?Thr?Ala?Lys?Ala?Gly?Thr?Gly?Thr?His?Gly?Thr?Ala?Phe

770 775 780

Asn?Val?Thr?Lys?Gln?Thr?Glu?Glu?Leu?Ala?Leu?Ile?Asn?Gly?Thr?Ser

785 790 795 800

Ile

<210>279

<211>765

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(85)..(765)

<223>FRXA01307

<400>279

ttccccaacc?cgcatccgct?acccatacat?cggtggcgtg?ctagttgata?tgtccgcgaa 60

gccaaggaac?gcctgggcga?tccg?gtg?ctg?gcg?tgg?cgc?gac?att?gta?gaa?acc 114

Val?Leu?Ala?Trp?Arg?Asp?Ile?Val?Glu?Thr

1 5 10

cca?gaa?aag?cgc?aaa?gca?tat?gta?tcc?cag?cgg?ggc?aaa?ggt?ggc?ctc 162

Pro?Glu?Lys?Arg?Lys?Ala?Tyr?Val?Ser?Gln?Arg?Gly?Lys?Gly?Gly?Leu

15 20 25

atc?cgc?gtt?cag?tat?gag?gaa?gcc?atg?gag?att?gct?gcg?gca?gcc?cat 210

Ile?Arg?Val?Gln?Tyr?Glu?Glu?Ala?Met?Glu?Ile?Ala?Ala?Ala?Ala?His

30 35 40

gtg?tac?acc?atc?cgc?caa?tac?ggc?ccc?gac?cgc?att?cat?gga?ttc?acc 258

Val?Tyr?Thr?Ile?Arg?Gln?Tyr?Gly?Pro?Asp?Arg?Ile?His?Gly?Phe?Thr

45 50 55

gtt?att?ccc?gca?atg?tcg?cag?gtg?tct?tac?ggt?gct?ggt?act?cgc?ttc 306

Val?Ile?Pro?Ala?Met?Ser?Gln?Val?Ser?Tyr?Gly?Ala?Gly?Thr?Arg?Phe

60 65 70

ttg?cag?atg?atc?ggc?gga?gtg?gcg?ctg?tcc?ttc?tac?gat?tgg?tac?gcc 354

Leu?Gln?Met?Ile?Gly?Gly?Val?Ala?Leu?Ser?Phe?Tyr?Asp?Trp?Tyr?Ala

75 80 85 90

gac?ctc?cca?cca?gca?tca?cca?caa?act?ttc?ggc?gat?caa?act?gac?gtt 402

Asp?Leu?Pro?Pro?Ala?Ser?Pro?Gln?Thr?Phe?Gly?Asp?Gln?Thr?Asp?Val

95 100 105

ccg?gaa?tct?ggc?gac?tgg?tac?aac?tcc?agc?tac?ctc?atg?atg?tgg?ggt 450

Pro?Glu?Ser?Gly?Asp?Trp?Tyr?Asn?Ser?Ser?Tyr?Leu?Met?Met?Trp?Gly

110 115 120

tcc?aac?att?ccg?gtg?acc?cgc?acg?cct?gac?tcc?cac?ttc?atg?gtg?gaa 498

Ser?Asn?Ile?Pro?Val?Thr?Arg?Thr?Pro?Asp?Ser?His?Phe?Met?Val?Glu

125 130 135

gcc?cgc?tac?aag?ggc?acc?aag?gtt?gtt?gtg?gtt?tcc?ccg?gat?ttc?gct 546

Ala?Arg?Tyr?Lys?Gly?Thr?Lys?Val?Val?Val?Val?Ser?Pro?Asp?Phe?Ala

140 145 150

gac?tcc?acc?aaa?ttt?gct?gat?gaa?tgg?gca?cgc?atc?cac?cct?ggt?act 594

Asp?Ser?Thr?Lys?Phe?Ala?Asp?Glu?Trp?Ala?Arg?Ile?His?Pro?Gly?Thr

155 160 165 170

gac?ggc?gca?ctc?gcc?ttt?gcc?atg?ggc?cat?gtg?atc?ttg?aag?gaa?ttc 642

Asp?Gly?Ala?Leu?Ala?Phe?Ala?Met?Gly?His?Val?Ile?Leu?Lys?Glu?Phe

175 180 185

cat?gtt?gac?aag?aag?acg?ccg?tacttc?atg?gac?tac?atg?cgc?aaa?tac 690

His?Val?Asp?Lys?Lys?Thr?Pro?Tyr?Phe?Met?Asp?Tyr?Met?Arg?Lys?Tyr

190 195 200

acg?gac?tct?cct?ttc?ctc?gtg?gaa?tta?gat?gag?cac?ggc?gat?ggc?acc 738

Thr?Asp?Ser?Pro?Phe?Leu?Val?Glu?Leu?Asp?Glu?His?Gly?Asp?Gly?Thr

205 210 215

tac?acc?cca?ggt?aaa?ttc?ctc?act?gca 765

Tyr?Thr?Pro?Gly?Lys?Phe?Leu?Thr?Ala

220 225

<210>280

<211>227

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>280

Val?Leu?Ala?Trp?Arg?Asp?Ile?Val?Glu?Thr?Pro?Glu?Lys?Arg?Lys?Ala

1 5 10 15

Tyr?Val?Ser?Gln?Arg?Gly?Lys?Gly?Gly?Leu?Ile?Arg?Val?Gln?Tyr?Glu

20 25 30

Glu?Ala?Met?Glu?Ile?Ala?Ala?Ala?Ala?His?Val?Tyr?Thr?Ile?Arg?Gln

35 40 45

Tyr?Gly?Pro?Asp?Arg?Ile?His?Gly?Phe?Thr?Val?Ile?Pro?Ala?Met?Ser

50 55 60

Gln?Val?Ser?Tyr?Gly?Ala?Gly?Thr?Arg?Phe?Leu?Gln?Met?Ile?Gly?Gly

65 70 75 80

Val?Ala?Leu?Ser?Phe?Tyr?Asp?Trp?Tyr?Ala?Asp?Leu?Pro?Pro?Ala?Ser

85 90 95

Pro?Gln?Thr?Phe?Gly?Asp?Gln?Thr?Asp?Val?Pro?Glu?Ser?Gly?Asp?Trp

100 105 110

Tyr?Asn?Ser?Ser?Tyr?Leu?Met?Met?Trp?Gly?Ser?Asn?Ile?Pro?Val?Thr

115 120 125

Arg?Thr?Pro?Asp?Ser?His?Phe?Met?Val?Glu?Ala?Arg?Tyr?Lys?Gly?Thr

130 135 140

Lys?Val?ValVal?Val?Ser?Pro?Asp?Phe?Ala?Asp?Ser?Thr?Lys?Phe?Ala

145 150 155 160

Asp?Glu?Trp?Ala?Arg?Ile?His?Pro?Gly?Thr?Asp?Gly?Ala?Leu?Ala?Phe

165 170 175

Ala?Met?Gly?His?Val?Ile?Leu?Lys?Glu?Phe?His?Val?Asp?Lys?Lys?Thr

180 185 190

Pro?Tyr?Phe?Met?Asp?Tyr?Met?Arg?Lys?Tyr?Thr?Asp?Ser?Pro?Phe?Leu

195 200 205

Val?Glu?Leu?Asp?Glu?His?Gly?Asp?Gly?Thr?Tyr?Thr?Pro?Gly?Lys?Phe

210 215 220

Leu?Thr?Ala

225

<210>281

<211>1206

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(1206)

<223>FRXA01308

<400>281

gcc?gcc?act?cca?aat?gcc?acc?cac?cgt?ctc?ctt?gtg?ctg?caa?aaa?gat 48

Ala?Ala?Thr?Pro?Asn?Ala?Thr?His?Arg?Leu?Leu?Val?Leu?Gln?Lys?Asp

1 5 10 15

ggc?tca?gtt?gta?gat?ccc?ggt?ggc?act?gtc?gcg?gac?cgt?tgg?ggt?gaa 96

Gly?Ser?Val?Val?Asp?Pro?Gly?Gly?Thr?Val?Ala?Asp?Arg?Trp?Gly?Glu

20 25 30

gaa?ggc?atg?ggt?aag?tgg?aat?ctg?cgc?tta?gac?ggc?gta?gat?cca?gtg 144

Glu?Gly?Met?Gly?Lys?Trp?Asn?Leu?Arg?Leu?Asp?Gly?Val?Asp?Pro?Val

35 40 45

atg?act?att?gca?gat?gta?cag?act?gac?acc?gaa?act?gcg?gaa?gtc?ctc 192

Met?Thr?Ile?Ala?Asp?Val?Gln?Thr?Asp?Thr?Glu?Thr?Ala?Glu?Val?Leu

50 55 60

ttc?ccc?cgc?ttc?gat?ctc?cca?gca?act?gcc?acc?caa?gaa?ggc?ccc?att 240

Phe?Pro?Arg?Phe?Asp?Leu?Pro?Ala?Thr?Ala?Thr?Gln?Glu?Gly?Pro?Ile

65 70 75 80

ggt?gct?ggc?acc?atc?agc?cgg?ggc?gtt?ccc?acc?atc?acg?ttg?aat?ggc 288

Gly?Ala?Gly?Thr?Ile?Ser?Arg?Gly?Val?Pro?Thr?Ile?Thr?Leu?Asn?Gly

85 90 95

cga?aag?tac?acc?act?gtc?ttt?gat?gtg?ttg?ctc?gca?cac?tac?ggt?gtg 336

Arg?Lys?Tyr?Thr?Thr?Val?Phe?Asp?Val?Leu?Leu?Ala?His?Tyr?Gly?Val

100 105 110

aac?cgc?gaa?gag?ctc?aac?ctt?cct?ggt?gag?tgg?cct?aag?gat?ttc?cag 384

Asn?Arg?Glu?Glu?Leu?Asn?Leu?Pro?Gly?Glu?Trp?Pro?Lys?Asp?Phe?Gln

115 120 125

gat?cca?gtc?atg?ggt?act?cct?gcg?tgg?cag?gaa?gag?ctc?acg?ggt?gtt 432

Asp?Pro?Val?Met?Gly?Thr?Pro?Ala?Trp?Gln?Glu?Glu?Leu?Thr?Gly?Val

130 135 140

cct?gct?aat?cag?gcg?att?cgt?ttg?ggt?cgg?gaa?ttt?gct?cag?aat?gct 480

Pro?Ala?Asn?Gln?Ala?Ile?Arg?Leu?Gly?Arg?Glu?Phe?Ala?Gln?Asn?Ala

145 150 155 160

gat?gat?tcc?aag?ggc?cgt?tcc?cag?atc?atc?atg?ggt?gct?ggt?gtg?aac 528

Asp?Asp?Ser?Lys?Gly?Arg?Ser?Gln?lle?Ile?Met?Gly?Ala?Gly?Val?Asn

165 170 175

cac?tac?ttc?cat?gcg?gat?tct?att?tat?cgc?aca?ttc?ttg?gcg?ctg?acc 576

His?Tyr?Phe?His?Ala?Asp?Ser?Ile?Tyr?Arg?Thr?Phe?Leu?Ala?Leu?Thr

180 185 190

tct?atg?tgt?ggc?acc?caa?ggt?gtt?aac?ggt?ggc?ggt?tgg?gct?cac?tac 624

Ser?Met?Cys?Gly?Thr?Gln?Gly?Val?Asn?Gly?Gly?Gly?Trp?Ala?His?Tyr

195 200 205

gtt?ggt?cag?gag?aaa?ctc?cgt?cca?atg?aat?ggt?tgg?gca?cag?tat?gcc 672

Val?Gly?Gln?Glu?Lys?Leu?Arg?Pro?Met?Asn?Gly?Trp?Ala?Gln?Tyr?Ala

210 215 220

ttt?gct?aca?gac?tgg?cag?cgt?cca?cca?cgt?cag?atg?atc?acc?act?ggt 720

Phe?Ala?Thr?Asp?Trp?Gln?Arg?Pro?Pro?Arg?Gln?Met?Ile?Thr?Thr?Gly

225 230 235 240

ttc?tac?tac?ctc?acc?acg?gat?cag?tgg?agg?tat?gac?aac?act?cgt?gct 768

Phe?Tyr?Tyr?Leu?Thr?Thr?Asp?Gln?Trp?Arg?Tyr?Asp?Asn?Thr?Arg?Ala

245 250 255

aat?cgt?ctg?gct?tcc?cca?ctg?gct?aat?cgt?ggc?acc?gtg?ggt?gac?aaa 816

Asn?Arg?Leu?Ala?Ser?Pro?Leu?Ala?Asn?Arg?Gly?Thr?Val?Gly?Asp?Lys

260 265 270

atg?acg?gcg?gat?acc?ttg?gtg?gaa?tcc?atg?aaa?cgt?gga?tgg?atg?ccg 864

Met?Thr?Ala?Asp?Thr?Leu?Val?Glu?Ser?Met?Lys?Arg?Gly?Trp?Met?Pro

275 280 285

tca?ttc?ccg?caa?ttc?aac?cgc?aat?ccc?ctc?atc?ttg?agc?cag?gag?gcg 912

Ser?Phe?Pro?Gln?Phe?Asn?Arg?Asn?Pro?Leu?Ile?Leu?Ser?Gln?Glu?Ala

290 295 300

gaa?gaa?aag?ggc?gtg?tct?gtt?tct?gac?cat?att?gtt?cag?cag?ctc?acc 960

Glu?Glu?Lys?Gly?Val?Ser?Val?Ser?Asp?His?Ile?Val?Gln?Gln?Leu?Thr

305 310 315 320

gat?ggt?gac?ttg?cag?ttc?gcc?tgc?gag?gat?ccg?gat?gca?ccg?gaa?aac 1008

Asp?Gly?Asp?Leu?Gln?Phe?Ala?Cys?Glu?Asp?Pro?Asp?Ala?Pro?Glu?Asn

325 330 335

tgg?cca?cgc?att?ctg?ctt?aac?tgg?cgc?aca?aac?cta?atg?ggc?tct?tca 1056

Trp?Pro?Arg?Ile?Leu?Leu?Asn?Trp?Arg?Thr?Asn?Leu?Met?Gly?Ser?Ser

340 345 350

gct?aag?ggc?acg?gag?ttt?ttc?ttg?cgc?cat?atg?ttg?ggt?gtg?gat?tct 1104

Ala?Lys?Gly?Thr?Glu?Phe?Phe?Leu?Arg?His?Met?Leu?Gly?Val?Asp?Ser

355 360 365

gat?gca?tct?gct?gaa?aaa?aac?gcg?ccg?gag?gat?cgt?cca?agt?tcc?att 1152

Asp?Ala?Ser?Ala?Glu?Lys?Asn?Ala?Pro?Glu?Asp?Arg?Pro?Ser?Ser?Ile

370 375 380

gtg?tgg?agg?gat?gaa?gct?tcc?gaa?ggg?aag?ctc?gat?ttg?atg?ctg?acc 1200

Val?Trp?Arg?Asp?Glu?Ala?Ser?Glu?Gly?Lys?Leu?Asp?Leu?Met?Leu?Thr

385 390 395 400

acg?gat 1206

Thr?Asp

<210>282

<211>402

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>282

Ala?Ala?Thr?Pro?Asn?Ala?Thr?His?Arg?Leu?Leu?Val?Leu?Gln?Lys?Asp

1 5 10 15

Gly?Ser?Val?Val?Asp?Pro?Gly?Gly?Thr?Val?Ala?Asp?Arg?Trp?Gly?Glu

20 25 30

Glu?Gly?Met?Gly?Lys?Trp?Asn?Leu?Arg?Leu?Asp?Gly?Val?Asp?Pro?Val

35 40 45

Met?Thr?Ile?Ala?Asp?Val?Gln?Thr?Asp?Thr?Glu?Thr?Ala?Glu?Val?Leu

50 55 60

Phe?Pro?Arg?Phe?Asp?Leu?Pro?Ala?Thr?Ala?Thr?Gln?Glu?Gly?Pro?Ile

65 70 75 80

Gly?Ala?Gly?Thr?Ile?Ser?Arg?Gly?Val?Pro?Thr?Ile?Thr?Leu?Asn?Gly

85 90 95

hrg?Lys?Tyr?Thr?Thr?Val?Phe?Asp?Val?Leu?Leu?Ala?His?Tyr?Gly?Val

100 105 110

Asn?Arg?Glu?Glu?Leu?Asn?Leu?Pro?Gly?Glu?Trp?Pro?Lys?Asp?Phe?Gln

115 120 125

Asp?Pro?Val?Met?Gly?Thr?Pro?Ala?Trp?Gln?Glu?Glu?Leu?Thr?Gly?Val

130 135 140

Pro?Ala?Asn?Gln?Ala?Ile?Arg?Leu?Gly?Arg?Glu?Phe?Ala?Gln?Asn?Ala

145 150 155 160

Asp?Asp?Ser?Lys?Gly?Arg?Ser?Gln?Ile?Ile?Met?Gly?Ala?Gly?Val?Asn

165 170 175

His?Tyr?Phe?His?Ala?Asp?Ser?Ile?Tyr?Arg?Thr?Phe?Leu?Ala?Leu?Thr

180 185 190

Ser?Met?Cys?Gly?Thr?Gln?Gly?Val?Asn?Gly?Gly?Gly?Trp?Ala?His?Tyr

195 200 205

Val?Gly?Gln?Glu?Lys?Leu?Arg?Pro?Met?Asn?Gly?Trp?Ala?Gln?Tyr?Ala

210 215 220

Phe?Ala?Thr?Asp?Trp?Gln?Arg?Pro?Pro?Arg?Gln?Met?Ile?Thr?Thr?Gly

225 230 235 240

Phe?Tyr?Tyr?Leu?Thr?Thr?Asp?Gln?Trp?Arg?Tyr?Asp?Asn?Thr?Arg?Ala

245 250 255

Asn?Arg?Leu?Ala?Ser?Pro?Leu?Ala?Asn?Arg?Gly?Thr?Val?Gly?Asp?Lys

260 265 270

Met?Thr?Ala?Asp?Thr?Leu?Val?Glu?Ser?Met?Lys?Arg?Gly?Trp?Met?Pro

275 280 285

Ser?Phe?Pro?Gln?Phe?Asn?Arg?Asn?Pro?Leu?Ile?Leu?Ser?Gln?Glu?Ala

290 295 300

Glu?Glu?Lys?Gly?Val?Ser?Val?Ser?Asp?His?Ile?Val?Gln?Gln?Leu?Thr

305 310 315 320

Asp?Gly?Asp?Leu?Gln?Phe?Ala?Cys?Glu?Asp?Pro?Asp?Ala?Pro?Glu?Asn

325 330 335

Trp?Pro?Arg?Ile?Leu?Leu?Asn?Trp?Arg?Thr?Asn?Leu?Met?Gly?Ser?Ser

340 345 350

Ala?Lys?Gly?Thr?Glu?Phe?Phe?Leu?Arg?His?Met?Leu?Gly?Val?Asp?Ser

355 360 365

Asp?Ala?Ser?Ala?Glu?Lys?Asn?Ala?Pro?Glu?Asp?Arg?Pro?Ser?Ser?Ile

370 375 380

Val?Trp?Arg?Asp?Glu?Ala?Ser?Glu?Gly?Lys?Leu?Asp?Leu?Met?Leu?Thr

385 390 395 400

Thr?Asp

<210>283

<211>824

<2l2>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(801)

<223>RXN01309

<400>283

att?gca?gac?cac?gaa?ggt?acc?cac?atc?aat?tgg?gac?atg?gtc?aaa?gaa 48

Ile?Ala?Asp?His?Glu?Gly?Thr?His?Ile?Asn?Trp?Asp?Met?Val?Lys?Glu

1 5 10 15

cgt?tcc?gcc?gag?gtg?atc?acc?tca?ccg?gag?tgg?act?ggt?tcc?aag?aag 96

Arg?Ser?Ala?Glu?Val?Ile?Thr?Ser?Pro?Glu?Trp?Thr?Gly?Ser?Lys?Lys

20 25 30

gac?gga?cgt?cgc?tac?acc?gcg?ttt?tcc?atc?aac?att?gaa?tac?gac?aag 144

Asp?Gly?Arg?Arg?Tyr?Thr?Ala?Phe?Ser?Ile?Asn?Ile?Glu?Tyr?Asp?Lys

35 40 45

ccg?tgg?cac?acc?ctg?tct?ggt?cgc?atg?cac?tac?tac?ctc?gac?cac?gat 192

Pro?Trp?His?Thr?Leu?Ser?Gly?Arg?Met?His?Tyr?Tyr?Leu?Asp?His?Asp

50 55 60

tgg?ttt?att?gat?tac?ggc?gag?cag?ttg?cca?atc?ttt?agg?cca?ccg?ttg 240

Trp?Phe?Ile?Asp?Tyr?Gly?Glu?Gln?Leu?Pro?Ile?Phe?Arg?Pro?Pro?Leu

65 70 75 80

gac?aag?atc?cac?atc?aat?ggt?gag?gtc?ggc?cct?ggc?cag?tcg?gtc?aca 288

Asp?Lys?Ile?His?Ile?Asn?Gly?Glu?Val?Gly?Pro?Gly?Gln?Ser?Val?Thr

85 90 95

ggc?acc?gac?ggc?gaa?cca?gaa?gta?acc?gtg?cgt?tat?ctg?acc?acc?cac 336

Gly?Thr?Asp?Gly?Glu?Pro?Glu?Val?Thr?Val?Arg?Tyr?Leu?Thr?Thr?His

100 105 110

aac?aag?tgg?tcg?att?cac?tcg?cag?tac?tac?gac?aat?ctg?cat?gtg?ctt 384

Asn?Lys?Trp?Ser?Ile?His?Ser?Gln?Tyr?Tyr?Asp?Asn?Leu?His?Val?Leu

115 120 125

tct?att?tct?cgt?ggc?ggc?cag?gtg?atc?tgg?atg?tcc?aac?aag?gat?gca 432

Ser?Ile?Ser?Arg?Gly?Gly?Gln?Val?Ile?Trp?Met?Ser?Asn?Lys?Asp?Ala

130 135 140

gag?aaa?ctc?ggt?atc?gct?gac?aac?gat?tgg?atc?gag?gct?tat?aac?cgc 480

Glu?Lys?Leu?Gly?Ile?Ala?Asp?Asn?Asp?Trp?Ile?Glu?Ala?Tyr?Asn?Arg

145 150 155 160

aac?ggc?gtt?gtt?tct?gct?cgt?gcg?att?gtc?tcc?cac?cgc?att?cct?gaa 528

Asn?Gly?Val?Val?Ser?Ala?Arg?Ala?Ile?Val?Ser?His?Arg?Ile?Pro?Glu

165 170 175

ggc?acc?gtg?ttt?atg?aac?cac?gcg?cag?gaa?cgc?acc?gct?ggc?acc?ccg 576

Gly?Thr?Val?Phe?Met?Asn?His?Ala?Gln?Glu?Arg?Thr?Ala?Gly?Thr?Pro

180 185 190

ctg?aac?gag?aag?tct?ggc?agg?cgc?ggc?gga?act?cac?aac?tct?ctt?act 624

Leu?Asn?Glu?Lys?Ser?Gly?Arg?Arg?Gly?Gly?Thr?His?Asn?Ser?Leu?Thr

195 200 205

cga?atc?atg?att?aag?ccg?gtc?cat?gtt?gcc?ggt?ggc?tac?ggc?cac?tta 672

Arg?Ile?Met?Ile?Lys?Pro?Val?His?Val?Ala?Gly?Gly?Tyr?Gly?His?Leu

210 215 220

acc?tat?ggc?ttc?aac?tac?atc?ggc?caa?ccg?gaa?ata?acc?gcg?atg?agg 720

Thr?Tyr?Gly?Phe?Asn?Tyr?Ile?Gly?Gln?Pro?Glu?Ile?Thr?Ala?Met?Arg

225 230 235 240

tca?cca?gaa?ttc?gtc?gcc?gct?ccc?agg?agg?tgc?agt?act?aat?gaa?ggt 768

Ser?Pro?Glu?Phe?Val?Ala?Ala?Pro?Arg?Arg?Cys?Ser?Thr?Asn?Glu?Gly

245 250 255

cat?ggc?tca?gat?cgc?aat?gat?cat?gaa?ctt?gga?taagtgcatt?ggctgccaca 821

His?Gly?Ser?Asp?Arg?Asn?Asp?His?Glu?Leu?Gly

260 265

cgt 824

<210>284

<211>267

<2l2>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>284

Ile?Ala?Asp?His?Glu?Gly?Thr?His?Ile?Asn?Trp?Asp?Met?Val?Lys?Glu

1 5 10 15

Arg?Ser?Ala?Glu?Val?Ile?Thr?Ser?Pro?Glu?Trp?Thr?Gly?Ser?Lys?Lys

20 25 30

Asp?Gly?Arg?Arg?Tyr?Thr?Ala?Phe?Ser?Ile?Asn?Ile?Glu?Tyr?Asp?Lys

35 40 45

Pro?Trp?His?Thr?Leu?Ser?Gly?Arg?Met?His?Tyr?Tyr?Leu?Asp?His?Asp

50 55 60

Trp?Phe?Ile?Asp?Tyr?Gly?Glu?Gln?Leu?Pro?Ile?Phe?Arg?Pro?Pro?Leu

65 70 75 80

Asp?Lys?Ile?His?Ile?Asn?Gly?Glu?Val?Gly?Pro?Gly?Gln?Ser?Val?Thr

85 90 95

Gly?Thr?Asp?Gly?Glu?Pro?Glu?Val?Thr?Val?Arg?Tyr?Leu?Thr?Thr?His

100 105 110

Asn?Lys?Trp?Ser?Ile?His?Ser?Gln?Tyr?Tyr?Asp?Asn?Leu?His?Val?Leu

115 120 125

Ser?Ile?Ser?Arg?Gly?Gly?Gln?Val?Ile?Trp?Met?Ser?Asn?Lys?Asp?Ala

130 135 140

Glu?Lys?Leu?Gly?Ile?Ala?Asp?Asn?Asp?Trp?Ile?Glu?Ala?Tyr?Asn?Arg

145 150 155 160

Asn?Gly?Val?Val?Ser?Ala?Arg?Ala?Ile?Val?Ser?His?Arg?Ile?Pro?Glu

165 170 175

Gly?Thr?Val?Phe?Met?Asn?His?Ala?Gln?Glu?Arg?Thr?Ala?Gly?Thr?Pro

180 185 190

Leu?Asn?Glu?Lys?Ser?Gly?Arg?Arg?Gly?Gly?Thr?His?Asn?Ser?Leu?Thr

195 200 205

Arg?Ile?Met?Ile?Lys?Pro?Val?His?Val?Ala?Gly?Gly?Tyr?Gly?His?Leu

210 215 220

Thr?Tyr?Gly?Phe?Asn?Tyr?Ile?Gly?Gln?Pro?Glu?Ile?Thr?Ala?Met?Arg

225 230 235 240

Ser?Pro?Glu?Phe?Val?Ala?Ala?Pro?Arg?Arg?Cys?Ser?Thr?Asn?Glu?Gly

245 250 255

His?Gly?Ser?Asp?Arg?Asn?Asp?His?Glu?Leu?Gly

260 265

<210>285

<211>692

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(669)

<223>FRXA01309

<400>285

att?gca?gac?cac?gaa?ggt?acc?cac?atc?aat?tgg?gac?atg?gtc?aaa?gaa 48

Ile?Ala?Asp?His?Glu?Gly?Thr?His?Ile?Asn?Trp?Asp?Met?Val?Lys?Glu

1 5 10 15

cgt?tcc?gcc?gag?gtg?atc?acc?tca?ccg?gag?tgg?act?ggt?tcc?aag?aag 96

Arg?Ser?Ala?Glu?Val?Ile?Thr?Ser?Pro?Glu?Trp?Thr?Gly?Ser?Lys?Lys

20 25 30

gac?gga?cgt?cgc?tac?acc?gcg?ttt?tcc?atc?aac?att?gaa?tac?gac?aag 144

Asp?Gly?Arg?Arg?Tyr?Thr?Ala?Phe?Ser?Ile?Asn?Ile?Glu?Tyr?Asp?Lys

35 40 45

ccg?tgg?cac?acc?ctg?tct?ggt?cgc?atg?cac?tac?tac?ctc?gac?cac?gat 192

Pro?Trp?His?Thr?Leu?Ser?Gly?Arg?Met?His?Tyr?Tyr?Leu?Asp?His?Asp

50 55 60

tgg?ttt?att?gat?tac?ggc?gag?cag?ttg?cca?atc?ttt?agg?cca?ccg?ttg 240

Trp?Phe?Ile?Asp?Tyr?Gly?Glu?Gln?Leu?Pro?Ile?Phe?Arg?Pro?Pro?Leu

65 70 75 80

gac?aag?atc?cac?atc?aat?ggt?gag?gtc?ggc?cct?ggc?cag?tcg?gtc?aca 288

Asp?Lys?Ile?His?Ile?Asn?Gly?Glu?Val?Gly?Pro?Gly?Gln?Ser?Val?Thr

85 90 95

ggc?acc?gac?ggc?gaa?cca?gaa?gta?acc?gtg?cgt?tat?ctg?acc?acc?cac 336

Gly?Thr?Asp?Gly?Glu?Pro?Glu?Val?Thr?Val?Arg?Tyr?Leu?Thr?Thr?His

100 105 110

aac?aag?tgg?tcg?att?cac?tcg?cag?tac?tac?gac?aat?ctg?cat?gtg?ctt 384

Asn?Lys?Trp?Ser?Ile?His?Ser?Gln?Tyr?Tyr?Asp?Asn?Leu?His?Val?Leu

115 120 125

tct?att?tct?cgt?ggc?ggc?cag?gtg?atc?tgg?atg?tcc?aac?aag?gat?gca 432

Ser?Ile?Ser?Arg?Gly?Gly?Gln?Val?Ile?Trp?Met?Ser?Asn?Lys?Asp?Ala

130 135 140

gag?aaa?ctc?ggt?atc?gct?gac?aac?gat?tgg?atc?gag?gct?tat?aac?cgc 480

Glu?Lys?Leu?Gly?Ile?Ala?Asp?Asn?Asp?Trp?Ile?Glu?Ala?Tyr?Asn?Arg

145 150 155 160

aac?ggc?gtt?gtt?tct?gct?cgt?gcg?att?gtc?tcc?cac?cgc?att?cct?gaa 528

Asn?Gly?Val?Val?Ser?Ala?Arg?Ala?Ile?Val?Ser?His?Arg?Ile?Pro?Glu

165 170 175

ggc?acc?gtg?ttt?atg?aac?cac?gcg?cag?gaa?ccc?acc?gct?ggc?acc?ccg 576

Gly?Thr?Val?Phe?Met?Asn?His?Ala?Gln?Glu?Pro?Thr?Ala?Gly?Thr?Pro

180 185 190

ctg?aac?gag?aag?tct?ggc?agg?cgc?ggc?gga?act?cac?aac?tct?ctt?act 624

Leu?Asn?Glu?Lys?Set?Gly?Arg?Arg?Gly?Gly?Thr?His?Asn?Set?Leu?Thr

195 200 205

cga?atc?atg?att?aaa?acg?gtc?cat?gtt?gcc?ggt?ggc?tac?ggc?act 669

Arg?Ile?Met?Ile?Lys?Thr?Val?His?Val?Ala?Gly?Gly?Tyr?Gly?Thr

210 215 220

taacctatgg?cttaactaca?tcg 692

<210>286

<211>223

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>286

Ile?Ala?Asp?His?Glu?Gly?Thr?His?Ile?Asn?Trp?Asp?Met?Val?Lys?Glu

1 5 10 15

Arg?Ser?Ala?Glu?Val?Ile?Thr?Ser?Pro?Glu?Trp?Thr?Gly?Ser?Lys?Lys

20 25 30

Asp?Gly?Arg?Arg?Tyr?Thr?Ala?Phe?Ser?Ile?Asn?Ile?Glu?Tyr?Asp?Lys

35 40 45

Pro?Trp?His?Thr?Leu?Ser?Gly?Arg?Met?His?Tyr?Tyr?Leu?Asp?His?Asp

50 55 60

Trp?Phe?Ile?Asp?Tyr?Gly?Glu?Gln?Leu?Pro?Ile?Phe?Arg?Pro?Pro?Leu

65 70 75 80

Asp?Lys?Ile?His?Ile?Asn?Gly?Glu?Val?Gly?Pro?Gly?Gln?Ser?Val?Thr

85 90 95

Gly?Thr?Asp?Gly?Glu?Pro?Glu?Val?Thr?Val?Arg?Tyr?Leu?Thr?Thr?His

100 105 110

Asn?Lys?Trp?Ser?Ile?His?Ser?Gln?Tyr?Tyr?Asp?Asn?Leu?His?Val?Leu

115 120 125

Ser?Ile?Ser?Arg?Gly?Gly?Gln?Val?Ile?Trp?Met?Ser?Asn?Lys?Asp?Ala

130 135 140

Glu?Lys?Leu?Gly?Ile?Ala?Asp?Asn?Asp?Trp?Ile?Glu?Ala?Tyr?Asn?Arg

145 150 155 160

Asn?Gly?Val?Val?Ser?Ala?Arg?Ala?Ile?Val?Ser?His?Arg?Ile?Pro?Glu

165 170 175

Gly?Thr?Val?Phe?Met?Asn?His?Ala?Gln?Glu?Pro?Thr?Ala?Gly?Thr?Pro

180 185 190

Leu?Asn?Glu?Lys?Ser?Gly?Arg?Arg?Gly?Gly?Thr?His?Asn?Ser?Leu?Thr

195 200 205

Arg?Ile?Met?Ile?Lys?Thr?Val?His?Val?Ala?Gly?Gly?Tyr?Gly?Thr

210 215 220

<210>287

<211>807

<2l2>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(784)

<223>RXA02017

<400>287

gcctgtggca?cgggagctcc?cagcggcaag?gtgagtctga?cctcgtggaa?cgttggcgaa 60

cgccccgctg?cgatgttccc?accaaggaag?gactaggcgg?atg?cgc?acc?cat?act 115

Met?Arg?Thr?His?Thr

1 5

ggc?aaa?att?ccg?gat?cac?ttt?gtg?cct?cgc?atc?tcc?atg?acg?gag?gag 163

Gly?Lys?Ile?Pro?Asp?His?Phe?Val?Pro?Arg?Ile?Ser?Met?Thr?Glu?Glu

10 15 20

cag?cgg?cgc?gtg?gtg?ttc?atg?ctg?aat?agt?ttg?ctg?ttg?gat?tat?cca 211

Gln?Arg?Arg?Val?Val?Phe?Met?Leu?Asn?Ser?Leu?Leu?Leu?Asp?Tyr?Pro

25 30 35

gag?gag?gga?ttc?gtc?gac?aag?cta?aat?gcc?gtc?gag?gcg?cag?ctt?gat 259

Glu?Glu?Gly?Phe?Val?Asp?Lys?Leu?Asn?Ala?Val?Glu?Ala?Gln?Leu?Asp

40 45 50

gtc?ctt?ccg?ctc?ccc?gtc?gcg?gcg?cac?gtg?gtc?gag?ttc?ctt?gac?gcg 307

Val?Leu?Pro?Leu?Pro?Val?Ala?Ala?His?Val?Val?Glu?Phe?Leu?Asp?Ala

55 60 65

gca?cgc?gtc?gct?ggg?cta?cgc?gcc?atg?cag?gaa?gcc?tac?gtt?gag?acc 355

Ala?Arg?Val?Ala?Gly?Leu?Arg?Ala?Met?Gln?Glu?Ala?Tyr?Val?Glu?Thr

70 75 80 85

ttt?gac?cag?cgc?cga?cgc?tgc?tca?ctg?ttt?ctc?acc?tac?tac?gct?gtg 403

Phe?Asp?Gln?Arg?Arg?Arg?Cys?Ser?Leu?Phe?Leu?Thr?Tyr?Tyr?Ala?Val

90 95 100

ggc?gac?acc?cgg?cag?cgc?ggc?acg?gcg?atc?ctc?acc?ttc?cgt?caa?acg 451

Gly?Asp?Thr?Arg?Gln?Arg?Gly?Thr?Ala?Ile?Leu?Thr?Phe?Arg?Gln?Thr

105 110 115

ctg?caa?cag?ctc?gga?ttt?gaa?tcc?gag?cgc?gac?gaa?ttg?ccc?gac?cac 499

Leu?Gln?Gln?Leu?Gly?Phe?Glu?Ser?Glu?Arg?Asp?Glu?Leu?Pro?Asp?His

120 125 130

ctc?tgc?gtc?gtg?ctt?gag?gcc?gca?gcg?ctt?gct?gat?tct?tcg?ctt?ttc 547

Leu?Cys?Val?Val?Leu?Glu?Ala?Ala?Ala?Leu?Ala?Asp?Ser?Ser?Leu?Phe

135 140 145

gac?gcc?gcc?acc?cag?gtg?tta?tca?gct?cac?cgc?gac?ggc?atc?gaa?gtg 595

Asp?Ala?Ala?Thr?Gln?Val?Leu?Ser?Ala?His?Arg?Asp?Gly?Ile?Glu?Val

150 155 160 165

ttg?cgc?gca?gcc?ctc?gac?aac?ctc?gac?tcg?ccc?tac?aga?tac?ctg?atc 643

Leu?Arg?Ala?Ala?Leu?Asp?Asn?Leu?Asp?Ser?Pro?Tyr?Arg?Tyr?Leu?Ile

170 175 180

atg?tct?ttg?tgc?cag?gca?ttg?cca?gaa?atc?gat?gaa?gaa?acc?gcc?aac 691

Met?Ser?Leu?Cys?Gln?Ala?Leu?Pro?Glu?Ile?Asp?Glu?Glu?Thr?Ala?Asn

185 190 195

agc?tac?atg?gag?ctc?atc?cgc?agc?ggt?cca?cca?gca?gaa?atg?gtg?ggc 739

Ser?Tyr?Met?Glu?Leu?Ile?Arg?Ser?Gly?Pro?Pro?Ala?Glu?Met?Val?Gly

200 205 210

atc?ggc?acg?cct?cta?ccg?ttc?ccc?acc?tca?caa?ccg?gac?att?cac 784

Ile?Gly?Thr?Pro?Leu?Pro?Phe?Pro?Thr?Ser?Gln?Pro?Asp?Ile?His

215 220 225

taggacacac?tatgtcaaac?ttt 807

<210>288

<211>228

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>288

Met?Arg?Thr?His?Thr?Gly?Lys?Ile?Pro?Asp?His?Phe?Val?Pro?Arg?Ile

1 5 10 15

Ser?Met?Thr?Glu?Glu?Gln?Arg?Arg?Val?Val?Phe?Met?Leu?Asn?Ser?Leu

20 25 30

Leu?Leu?Asp?Tyr?Pro?Glu?Glu?Gly?Phe?Val?Asp?Lys?Leu?Asn?Ala?Val

35 40 45

Glu?Ala?Gln?Leu?Asp?Val?Leu?Pro?Leu?Pro?Val?Ala?Ala?His?Val?Val

50 55 60

Glu?Phe?Leu?Asp?Ala?Ala?Arg?Val?Ala?Gly?Leu?Arg?Ala?Met?Gln?Glu

65 70 75 80

Ala?Tyr?Val?Glu?Thr?Phe?Asp?Gln?Arg?Arg?Arg?Cys?Ser?Leu?Phe?Leu

85 90 95

Thr?Tyr?Tyr?Ala?Val?Gly?Asp?Thr?Arg?Gln?Arg?Gly?Thr?Ala?Ile?Leu

100 105 110

Thr?Phe?Arg?Gln?Thr?Leu?Gln?Gln?Leu?Gly?Phe?Glu?Ser?Glu?Arg?Asp

115 120 125

Glu?Leu?Pro?Asp?His?Leu?Cys?Val?Val?Leu?Glu?Ala?Ala?Ala?Leu?Ala

130 135 140

Asp?Ser?Ser?Leu?Phe?Asp?Ala?Ala?Thr?Gln?Val?Leu?Ser?Ala?His?Arg

145 150 155 160

Asp?Gly?Ile?Glu?Val?Leu?Arg?Ala?Ala?Leu?Asp?Asn?Leu?Asp?Ser?Pro

165 170 175

Tyr?Arg?Tyr?Leu?Ile?Met?Ser?Leu?Cys?Gln?Ala?Leu?Pro?Glu?Ile?Asp

180 185 190

Glu?Glu?Thr?Ala?Asn?Ser?Tyr?Met?Glu?Leu?Ile?Arg?Ser?Gly?Pro?Pro

195 200 205

Ala?Glu?Met?Val?Gly?Ile?Gly?Thr?Pro?Leu?Pro?Phe?Pro?Thr?Ser?Gln

210 215 220

Pro?Asp?Ile?His

225

<210>289

<211>1073

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(1050)

<223>RXA02018

<400>289

cgc?atc?tgc?gag?cac?tgc?ctc?aac?ccc?acc?tgt?gtg?tcc?tcc?tgc?cca 48

Arg?Ile?Cys?Glu?His?Cys?Leu?Asn?Pro?Thr?Cys?Val?Ser?Ser?Cys?Pro

1 5 10 15

tcc?ggt?gct?atg?tac?aaa?cgc?gcc?gaa?gac?ggc?atc?gtg?ctg?gtt?gac 96

Ser?Gly?Ala?Met?Tyr?Lys?Arg?Ala?Glu?Asp?Gly?Ile?Val?Leu?Val?Asp

20 25 30

cag?gat?caa?tgc?cgt?ggc?tgg?cgc?atg?tgt?gtt?tcc?ggc?tgc?ccc?tac 144

Gln?Asp?Gln?Cys?Arg?Gly?Trp?Arg?Met?Cys?Val?Ser?Gly?Cys?Pro?Tyr

35 40 45

aaa?aag?gtc?tac?ttc?aat?cac?aaa?tcg?ggc?aag?gcc?gaa?aag?tgt?acg 192

Lys?Lys?Val?Tyr?Phe?Asn?His?Lys?Ser?Gly?Lys?Ala?Glu?Lys?Cys?Thr

50 55 60

ctg?tgc?tat?ccg?cgc?ctc?gag?gtc?ggc?cag?ccg?acc?gtg?tgc?tcc?gag 240

Leu?Cys?Tyr?Pro?Arg?Leu?Glu?Val?Gly?Gln?Pro?Thr?Val?Cys?Ser?Glu

65 70 75 80

acg?tgc?gtg?ggt?cgc?ttg?cgc?tac?ttg?ggc?gtt?ttg?ctt?tac?gac?gcc 288

Thr?Cys?Val?Gly?Arg?Leu?Arg?Tyr?Leu?Gly?Val?Leu?Leu?Tyr?Asp?Ala

85 90 95

gac?cgt?gtc?gct?gaa?gtc?gcc?gcc?acg?cca?gac?gaa?aag?gat?ctt?ttc 336

Asp?Arg?Val?Ala?Glu?Val?Ala?Ala?Thr?Pro?Asp?Glu?Lys?Asp?Leu?Phe

100 105 110

gaa?gcc?caa?aag?acc?ctc?ttc?cta?gat?ccc?cac?gac?cca?cag?gtg?atc 384

Glu?Ala?Gln?Lys?Thr?Leu?Phe?Leu?Asp?Pro?His?Asp?Pro?Gln?Val?Ile

115 120 125

gcc?gac?gcc?caa?cgc?aac?ggc?atc?ccg?cac?tcc?tgg?ctc?gaa?gct?gcg 432

Ala?Asp?Ala?Gln?Arg?Asn?Gly?Ile?Pro?His?Ser?Trp?Leu?Glu?Ala?Ala

130 135 140

cag?aac?tct?cca?att?tac?gat?ctc?atc?ttc?aaa?tac?gag?gtt?gcc?ctc 480

Gln?Asn?Ser?Pro?Ile?Tyr?Asp?Leu?Ile?Phe?Lys?Tyr?Glu?Val?Ala?Leu

145 150 155 160

ccg?ctt?cac?cct?gaa?tac?cgc?acc?ttg?ccg?atg?gtt?tgg?tac?att?ccg 528

Pro?Leu?His?Pro?Glu?Tyr?Arg?Thr?Leu?Pro?Met?Val?Trp?Tyr?Ile?Pro

165 170 175

cca?cta?agc?ccc?atc?gtt?gat?gag?gtg?acc?gcg?tcc?ggc?aac?gac?ggc 576

Pro?Leu?Ser?Pro?Ile?Val?Asp?Glu?Val?Thr?Ala?Ser?Gly?Asn?Asp?Gly

180 185 190

gaa?gac?cac?aag?atc?ctg?ctc?acc?gcg?ctg?tcc?acc?atg?cgc?atc?ccg 624

Glu?Asp?His?Lys?Ile?Leu?Leu?Thr?Ala?Leu?Ser?Thr?Met?Arg?Ile?Pro

195 200 205

ctg?gaa?tac?ctg?gct?gga?ttg?ttc?act?gcc?ggt?gat?acc?agg?ccg?gtg 672

Leu?Glu?Tyr?Leu?Ala?Gly?Leu?Phe?Thr?Ala?Gly?Asp?Thr?Arg?Pro?Val

210 215 220

gaa?aaa?tcc?ctc?cga?cgc?cta?gcc?gcc?atg?cga?tca?tat?atg?cgc?gat 720

Glu?Lys?Ser?Leu?Arg?Arg?Leu?Ala?Ala?Met?Arg?Ser?Tyr?Met?Arg?Asp

225 230 235 240

atc?agt?ttg?ggc?cgc?gaa?cct?cag?gaa?gaa?atc?gca?gag?gct?gtc?gga 768

Ile?Ser?Leu?Gly?Arg?Glu?Pro?Gln?Glu?Glu?Ile?Ala?Glu?Ala?Val?Gly

245 250 255

atg?acc?ggc?aag?gtg?gtg?cag?gaa?atg?tat?cgc?atc?ctg?gcc?att?gcc 816

Met?Thr?Gly?Lys?Val?Val?Gln?Glu?Met?Tyr?Arg?Ile?Leu?Ala?Ile?Ala

260 265 270

aag?tat?gac?gat?cgc?tat?gtc?atc?ccc?acc?gcc?tcc?cct?gag?acc?ccg 864

Lys?Tyr?Asp?Asp?Arg?Tyr?Val?Ile?Pro?Thr?Ala?Ser?Pro?Glu?Thr?Pro

275 280 285

cgc?gga?att?tct?tcc?ctg?gat?cct?ttc?ggc?gat?gtc?gat?cca?gcc?cga 912

Arg?Gly?Ile?Ser?Ser?Leu?Asp?Pro?Phe?Gly?Asp?Val?Asp?Pro?Ala?Arg

290 295 300

gcc?acc?gag?cag?ctc?aac?atc?ggt?ttg?ggc?gaa?ggc?gct?cca?gag?gcc 960

Ala?Thr?Glu?Gln?Leu?Asn?Ile?Gly?Leu?Gly?Glu?Gly?Ala?Pro?Glu?Ala

305 310 315 320

tgt?ggc?acg?gga?gct?ccc?agc?ggc?aag?gtg?agt?ctg?acc?tcg?tgg?aac 1008

Cys?Gly?Thr?Gly?Ala?Pro?Ser?Gly?Lys?Val?Ser?Leu?Thr?Ser?Trp?Asn

325 330 335

gtt?ggc?gaa?cgc?ccc?gct?gcg?atg?ttc?cca?cca?agg?aag?gac 1050

Val?Gly?Glu?Arg?Pro?Ala?Ala?Met?Phe?Pro?Pro?Arg?Lys?Asp

340 345 350

taggcggatg?cgcacccata?ctg 1073

<210>290

<211>350

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>290

Arg?Ile?Cys?Glu?His?Cys?Leu?Asn?Pro?Thr?Cys?Val?Ser?Ser?Cys?Pro

1 5 10 15

Ser?Gly?Ala?Met?Tyr?Lys?Arg?Ala?Glu?Asp?Gly?Ile?Val?Leu?Val?Asp

20 25 30

Gln?Asp?Gln?Cys?Arg?Gly?Trp?Arg?Met?Cys?Val?Ser?Gly?Cys?Pro?Tyr

35 40 45

Lys?Lys?Val?Tyr?Phe?Asn?His?Lys?Ser?Gly?Lys?Ala?Glu?Lys?Cys?Thr

50 55 60

Leu?Cys?Tyr?Pro?Arg?Leu?Glu?Val?Gly?Gln?Pro?Thr?Val?Cys?Ser?Glu

65 70 75 80

Thr?Cys?Val?Gly?Arg?Leu?Arg?Tyr?Leu?Gly?Val?Leu?Leu?Tyr?Asp?Ala

85 90 95

Asp?Arg?Val?Ala?Glu?Val?Ala?Ala?Thr?Pro?Asp?Glu?Lys?Asp?Leu?Phe

100 105 110

Glu?Ala?Gln?Lys?Thr?Leu?Phe?Leu?Asp?Pro?His?Asp?Pro?Gln?Val?Ile

115 120 125

Ala?Asp?Ala?Gln?Arg?Asn?Gly?Ile?Pro?His?Ser?Trp?Leu?Glu?Ala?Ala

130 135 140

Gln?Asn?Ser?Pro?Ile?Tyr?Asp?Leu?Ile?Phe?Lys?Tyr?Glu?Val?Ala?Leu

145 150 155 160

Pro?Leu?His?Pro?Glu?Tyr?Arg?Thr?Leu?Pro?Met?Val?Trp?Tyr?Ile?Pro

165 170 175

Pro?Leu?Ser?Pro?Ile?Val?Asp?Glu?Val?Thr?Ala?Ser?Gly?Asn?Asp?Gly

180 185 190

Glu?Asp?His?Lys?Ile?Leu?Leu?Thr?Ala?Leu?Ser?Thr?Met?Arg?Ile?Pro

195 200 205

Leu?Glu?Tyr?Leu?Ala?Gly?Leu?Phe?Thr?Ala?Gly?Asp?Thr?Arg?Pro?Val

210 215 220

Glu?Lys?Ser?Leu?Arg?Arg?Leu?Ala?Ala?Met?Arg?Ser?Tyr?Met?Arg?Asp

225 230 235 240

Ile?Ser?Leu?Gly?Arg?Glu?Pro?Gln?Glu?Glu?Ile?Ala?Glu?Ala?Val?Gly

245 250 255

Met?Thr?Gly?Lys?Val?Val?Gln?Glu?Met?Tyr?Arg?Ile?Leu?Ala?Ile?Ala

260 265 270

Lys?Tyr?Asp?Asp?Arg?Tyr?Val?Ile?Pro?Thr?Ala?Ser?Pro?Glu?Thr?Pro

275 280 285

Arg?Gly?Ile?Ser?Ser?Leu?Asp?Pro?Phe?Gly?Asp?Val?Asp?Pro?Ala?Arg

290 295 300

Ala?Thr?Glu?Gln?Leu?Asn?Ile?Gly?Leu?Gly?Glu?Gly?Ala?Pro?Glu?Ala

305 310 315 320

Cys?Gly?Thr?Gly?Ala?Pro?Ser?Gly?Lys?Val?Ser?Leu?Thr?Ser?Trp?Asn

325 330 335

Val?Gly?Glu?Arg?Pro?Ala?Ala?Met?Phe?Pro?Pro?Arg?Lys?Asp

340 345 350

<210>291

<211>900

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(877)

<223>RXA02016

<400>291

acatggagct?catccgcagc?ggtccaccag?cagaaatggt?gggcatcggc?acgcctctac 60

cgttccccac?ctcacaaccg?gacattcact?aggacacact?atg?tca?aac?ttt?gaa 115

Met?Ser?Asn?Phe?Glu

1 5

acg?ttc?ctc?tgg?gtt?gcc?tac?ccc?tgg?ctg?tgt?atc?gcc?gcc?tac?atc 163

Thr?Phe?Leu?Trp?Val?Ala?Tyr?Pro?Trp?Leu?Cys?Ile?Ala?Ala?Tyr?Ile

10 15 20

atc?ggc?att?tct?tgg?cgc?tgg?cgc?gcc?gac?caa?ttc?ggt?tgg?acc?acc 211

Ile?Gly?Ile?Ser?Trp?Arg?Trp?Arg?Ala?Asp?Gln?Phe?Gly?Trp?Thr?Thr

25 30 35

cac?tcc?tcc?caa?atc?tac?gaa?tcc?aaa?ctc?ctc?cgc?atc?gcc?tcc?cca 259

His?Ser?Ser?Gln?Ile?Tyr?Glu?Ser?Lys?Leu?Leu?Arg?Ile?Ala?Ser?Pro

40 45 50

ctc?ttc?cac?tgg?ggc?atg?gtg?ttc?gtg?gtg?atc?ggc?cac?ctc?atg?gga 307

Leu?Phe?His?Trp?Gly?Met?Val?Phe?Val?Val?Ile?Gly?His?Leu?Met?Gly

55 60 65

ctt?gcc?atc?ccc?aag?agc?tgg?acc?caa?gct?gta?gga?att?tct?gac?gcc 355

Leu?Ala?Ile?Pro?Lys?Ser?Trp?Thr?Gln?Ala?Val?Gly?Ile?Ser?Asp?Ala

70 75 80 85

gct?tac?cac?ctc?atc?gcc?acc?atc?cca?ggc?acc?att?gcc?ggc?atc?gct 403

Ala?Tyr?His?Leu?Ile?Ala?Thr?Ile?Pro?Gly?Thr?Ile?Ala?Gly?Ile?Ala

90 95 100

gca?gtc?ctt?gga?ctc?atc?ggc?ttg?att?atc?cgt?cgc?gtg?atc?aac?aaa 451

Ala?Val?Leu?Gly?Leu?Ile?Gly?Leu?Ile?Ile?Arg?Arg?Val?Ile?Asn?Lys

105 110 115

acc?gtc?ttc?ctg?tcc?acc?tca?cgc?tcc?gac?aaa?gtg?atg?tat?gtg?cta 499

Thr?Val?Phe?Leu?Ser?Thr?Ser?Arg?Ser?Asp?Lys?Val?Met?Tyr?Val?Leu

120 125 130

ctc?ggc?gct?gca?att?ttg?tcc?ggt?ttc?atc?gcc?acc?gtc?tcc?acc?cag 547

Leu?Gly?Ala?Ala?Ile?Leu?Ser?Gly?Phe?Ile?Ala?Thr?Val?Ser?Thr?Gln

135 140 145

gtc?ttc?ggc?ggc?gca?cac?ggc?tac?gac?tac?cgc?gaa?acc?atc?tcc?cca 595

Val?Phe?Gly?Gly?Ala?His?Gly?Tyr?Asp?Tyr?Arg?Glu?Thr?Ile?Ser?Pro

150 155 160 165

tgg?gtg?cgc?caa?ctg?ctc?atc?ttc?aac?gct?caa?cca?gag?ctc?atg?gct 643

Trp?Val?Arg?Gln?Leu?Leu?Ile?Phe?Asn?Ala?Gln?Pro?Glu?Leu?Met?Ala

170 175 180

gat?gtc?cct?tgg?gaa?ttc?aag?gtc?cac?atc?gtc?gct?gga?ttc?acc?ctc 691

Asp?Val?Pro?Trp?Glu?Phe?Lys?Val?His?Ile?Val?Ala?Gly?Phe?Thr?Leu

185 190 195

atc?gca?ctg?tgg?cca?ttc?acc?cgc?cta?gtc?cac?gcg?ttc?tcc?gca?cca 739

Ile?Ala?Leu?Trp?Pro?Phe?Thr?Arg?Leu?Val?His?Ala?Phe?Ser?Ala?Pro

200 205 210

gtt?gga?tac?gtc?acc?cgc?ccc?tac?gtg?gtc?tat?cgc?acc?cgc?gac?acc 787

Val?Gly?Tyr?Val?Thr?Arg?Pro?Tyr?Val?Val?Tyr?Arg?Thr?Arg?Asp?Thr

215 220 225

acc?tct?gaa?ccg?gca?cgc?caa?aac?gtc?gcc?tgg?gaa?ccg?atc?cgc?tcg 835

Thr?Ser?Glu?Pro?Ala?Arg?Gln?Asn?Val?Ala?Trp?Glu?Pro?Ile?Arg?Ser

230 235 240 245

gtc?aaa?aat?cag?ctc?gac?aat?gac?tcg?aaa?tgg?cac?ggc?gcc 877

Val?Lys?Asn?Gln?Leu?Asp?Asn?Asp?Ser?Lys?Trp?His?Gly?Ala

250 255

taaattcctc?acaagccccc?tag 900

<2l0>292

<211>259

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>292

Met?Ser?Asn?Phe?Glu?Thr?Phe?Leu?Trp?Val?Ala?Tyr?Pro?Trp?Leu?Cys

1 5 10 15

Ile?Ala?Ala?Tyr?Ile?Ile?Gly?Ile?Ser?Trp?Arg?Trp?Arg?Ala?Asp?Gln

20 25 30

Phe?Gly?Trp?Thr?Thr?His?Ser?Ser?Gln?lle?Tyr?Glu?Ser?Lys?Leu?Leu

35 40 45

Arg?Ile?Ala?Ser?Pro?Leu?Phe?His?Trp?Gly?Met?Val?Phe?Val?Val?Ile

50 55 60

Gly?His?Leu?Met?Gly?Leu?Ala?Ile?Pro?Lys?Ser?Trp?Thr?Gln?Ala?Val

65 70 75 80

Gly?Ile?Ser?Asp?Ala?Ala?Tyr?His?Leu?Ile?Ala?Thr?Ile?Pro?Gly?Thr

85 90 95

Ile?Ala?Gly?Ile?Ala?Ala?Val?Leu?Gly?Leu?Ile?Gly?Leu?lle?Ile?Arg

100 105 110

Arg?Val?Ile?Asn?Lys?Thr?Val?Phe?Leu?Ser?Thr?Ser?Arg?Ser?Asp?Lys

115 120 125

Val?Met?Tyr?Val?Leu?Leu?Gly?Ala?Ala?Ile?Leu?Ser?Gly?Phe?Ile?Ala

130 135 140

Thr?Val?Ser?Thr?Gln?Val?Phe?Gly?Gly?Ala?His?Gly?Tyr?Asp?Tyr?Arg

145 150 155 160

Glu?Thr?Ile?Ser?Pro?Trp?Val?Arg?Gln?Leu?Leu?Ile?Phe?Asn?Ala?Gln

165 170 175

Pro?Glu?Leu?Met?Ala?Asp?Val?Pro?Trp?Glu?Phe?Lys?Val?His?Ile?Val

180 185 190

Ala?Gly?Phe?Thr?Leu?Ile?Ala?Leu?Trp?Pro?Phe?Thr?Arg?Leu?Val?His

195 200 205

Ala?Phe?Ser?Ala?Pro?Val?Gly?Tyr?Val?Thr?Arg?Pro?Tyr?Val?Val?Tyr

210 215 220

Arg?Thr?Arg?Asp?Thr?Thr?Ser?Glu?Pro?Ala?Arg?Gln?Asn?Val?Ala?Trp

225 230 235 240

Glu?Pro?Ile?Arg?Ser?Val?Lys?Asn?Gln?Leu?Asp?Asn?Asp?Ser?Lys?Trp

245 250 255

His?Gly?Ala

<210>293

<211>813

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(790)

<223>RXA00471

<400>293

acgcatcaaa?tctgaaatcg?gcgaaggcac?cgaagtggca?atcaccatgg?atgtgtagtt 60

ggtcgtacgc?gcgtgtcttc?ggggctgtaa?cctgaaaggc?atg?gtt?gat?gtg?ttt 115

Met?Val?Asp?Val?Phe

1 5

ttg?gtc?gat?gac?cac?tcc?gtg?ttt?cgc?tcc?ggc?gtc?aaa?gca?gaa?cta 163

Leu?Val?Asp?Asp?His?Ser?Val?Phe?Arg?Ser?Gly?Val?Lys?Ala?Glu?Leu

10 15 20

ggc?aac?gcc?gtc?aca?gta?gtc?ggc?gaa?gca?ggg?acg?gtg?gcc?gac?gcc 211

Gly?Asn?Ala?Val?Thr?Val?Val?Gly?Glu?Ala?Gly?Thr?Val?Ala?Asp?Ala

25 30 35

gta?gcc?ggc?atc?aag?gca?agc?aaa?cca?gag?gta?gtg?ctt?ctc?gac?gtc 259

Val?Ala?Gly?Ile?Lys?Ala?Ser?Lys?Pro?Glu?Val?Val?Leu?Leu?Asp?Val

40 45 50

cac?atg?ccc?gac?ggc?ggc?ggc?ctc?gca?gtg?ctc?cag?cag?atc?aac?gac 307

His?Met?Pro?Asp?Gly?Gly?Gly?Leu?Ala?Val?Leu?Gln?Gln?Ile?Asn?Asp

55 60 65

tcc?gat?gtg?gac?acc?att?ttc?ttg?gca?ctc?agt?gtc?tct?gat?gct?gcg 355

Ser?Asp?Val?Asp?Thr?Ile?Phe?Leu?Ala?Leu?Ser?Val?Ser?Asp?Ala?Ala

70 75 80 85

gaa?gat?gtc?atc?gcc?atc?atc?cgt?ggc?ggt?gcc?agg?gga?tac?gtg?acc 403

Glu?Asp?Val?Ile?Ala?Ile?Ile?Arg?Gly?Gly?Ala?Arg?Gly?Tyr?Val?Thr

90 95 100

aaa?tca?atc?tcc?ggt?gaa?gaa?ctc?atc?gaa?gcc?atc?aac?cgc?gtg?aaa 451

Lys?Ser?Ile?Ser?Gly?Glu?Glu?Leu?Ile?Glu?Ala?Ile?Asn?Arg?Val?Lys

105 110 115

tcc?ggc?gac?gca?ttc?ttc?tca?cca?cgc?ctg?gca?ggc?ttt?gtc?ctc?gac 499

Ser?Gly?Asp?Ala?Phe?Phe?Ser?Pro?Arg?Leu?Ala?Gly?Phe?Val?Leu?Asp

120 125 130

gcc?ttc?gcc?gcc?ccc?gat?tcc?gca?gct?ggc?gca?ggc?att?gtc?gac?gca 547

Ala?Phe?Ala?Ala?Pro?Asp?Ser?Ala?Ala?Gly?Ala?Gly?Ile?Val?Asp?Ala

135 140 145

ccc?gaa?aaa?gac?gcc?gcc?gta?gaa?tcc?gga?aaa?atc?ctc?gac?gac?cca 595

Pro?Glu?Lys?Asp?Ala?Ala?Val?Glu?Ser?Gly?Lys?Ile?Leu?Asp?Asp?Pro

150 155 160 165

gtt?gtc?gac?gcc?ctc?acc?cgc?cgc?gaa?ctc?gaa?gtc?ctc?cgc?cta?cta 643

Val?Val?Asp?Ala?Leu?Thr?Arg?Arg?Glu?Leu?Glu?Val?Leu?Arg?Leu?Leu

170 175 180

gcc?cgc?ggc?tac?acc?tac?aaa?gaa?atc?ggc?aaa?gaa?ctg?ttc?att?tcc 691

Ala?Arg?Gly?Tyr?Thr?Tyr?Lys?Glu?Ile?Gly?Lys?Glu?Leu?Phe?Ile?Ser

185 190 195

gtc?aaa?acc?gtg?gaa?acc?cac?gcc?tca?aac?att?ctg?cgg?aaa?acc?caa 739

Val?Lys?Thr?Val?Glu?Thr?His?Ala?Ser?Asn?Ile?Leu?Arg?Lys?Thr?Gln

200 205 210

caa?tcc?aac?cgc?cac?gcg?ttg?acc?cgg?tgg?gct?cac?tcg?agg?gat?ctt 787

Gln?Ser?Asn?Arg?His?Ala?Leu?Thr?Arg?Trp?Ala?His?Ser?Arg?Asp?Leu

215 220 225

gac?taatggcggc?taaaaagagt?ggc 813

Asp

230

<210>294

<211>230

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>294

Met?Val?Asp?Val?Phe?Leu?Val?Asp?Asp?His?Ser?Val?Phe?Arg?Ser?Gly

1 5 10 15

Val?Lys?Ala?Glu?Leu?Gly?Asn?Ala?Val?Thr?Val?Val?Gly?Glu?Ala?Gly

20 25 30

Thr?Val?Ala?Asp?Ala?Val?Ala?Gly?Ile?Lys?Ala?Ser?Lys?Pro?Glu?Val

35 40 45

Val?Leu?Leu?Asp?Val?His?Met?Pro?Asp?Gly?Gly?Gly?Leu?Ala?Val?Leu

50 55 60

Gln?Gln?Ile?Asn?Asp?Ser?Asp?Val?Asp?Thr?Ile?Phe?Leu?Ala?Leu?Ser

65 70 75 80

Val?Ser?Asp?Ala?Ala?Glu?Asp?Val?Ile?Ala?Ile?Ile?Arg?Gly?Gly?Ala

85 90 95

Arg?Gly?Tyr?Val?Thr?Lys?Ser?Ile?Ser?Gly?Glu?Glu?Leu?Ile?Glu?Ala

100 105 110

Ile?Asn?Arg?Val?Lys?Ser?Gly?Asp?Ala?Phe?Phe?Ser?Pro?Arg?Leu?Ala

115 120 125

Gly?Phe?Val?Leu?Asp?Ala?Phe?Ala?Ala?Pro?Asp?Ser?Ala?Ala?Gly?Ala

130 135 140

Gly?Ile?Val?Asp?Ala?Pro?Glu?Lys?Asp?Ala?Ala?Val?Glu?Ser?Gly?Lys

145 150 155 160

Ile?Leu?Asp?Asp?Pro?Val?Val?Asp?Ala?Leu?Thr?Arg?Arg?Glu?Leu?Glu

165 170 175

Val?Leu?Arg?Leu?Leu?Ala?Arg?Gly?Tyr?Thr?Tyr?Lys?Glu?Ile?Gly?Lys

180 185 190

Glu?Leu?Phe?Ile?Ser?Val?Lys?Thr?Val?Glu?Thr?His?Ala?Ser?Asn?Ile

195 200 205

Leu?Arg?Lys?Thr?Gln?Gln?Ser?Asn?Arg?His?Ala?Leu?Thr?Arg?Trp?Ala

210 215 220

His?Ser?Arg?Asp?Leu?Asp

225 230

<210>295

<211>936

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(913)

<223>RXA00133

<400>295

gttacatcag?atgaggatgc?cctatgggtg?tacacatgcg?acgggtgtat?tgcaggagga 60

aatttgaagg?tggataccca?gcggattaaa?gatgatgaag?atg?cta?ttc?gtt?cgg 115

Met?Leu?Phe?Val?Arg

1 5

cgg?ctg?aca?tcg?ctg?aaa?acc?gca?aca?ggc?atc?cca?gtc?acc?atg?ttc 163

Arg?Leu?Thr?Ser?Leu?Lys?Thr?Ala?Thr?Gly?Ile?Pro?Val?Thr?Met?Phe

10 15 20

gcc?act?gtg?ttg?cag?gac?aat?cgc?ctg?caa?att?act?cag?tgg?gtt?ggg 211

Ala?Thr?Val?Leu?Gln?Asp?Asn?Arg?Leu?Gln?Ile?Thr?Gln?Trp?Val?Gly

25 30 35

ttg?cgt?acc?ccg?gct?ctg?cag?aat?ctg?gtc?att?gaa?cca?ggt?gtg?ggc 259

Leu?Arg?Thr?Pro?Ala?Leu?Gln?Asn?Leu?Val?Ile?Glu?Pro?Gly?Val?Gly

40 45 50

gtt?ggt?gga?cgc?gtc?gtc?gca?acc?cgt?cgt?ccg?gtt?ggt?gtg?agt?gat 307

Val?Gly?Gly?Arg?Val?Val?Ala?Thr?Arg?Arg?Pro?Val?Gly?Val?Ser?Asp

55 60 65

tac?acc?agg?gca?aat?gtc?att?tca?cat?gag?aag?gat?tcc?gcg?att?cag 355

Tyr?Thr?Arg?Ala?Asn?Val?Ile?Ser?His?Glu?Lys?Asp?Ser?Ala?Ile?Gln

70 75 80 85

gat?gag?ggc?ctt?cat?tcc?att?gtc?gca?gtt?ccc?gtg?atc?gtg?cac?cgc 403

Asp?Glu?Gly?Leu?His?Ser?Ile?Val?Ala?Val?Pro?Val?Ile?Val?His?Arg

90 95 100

gaa?att?cgt?ggc?gtt?ttg?tat?gtt?ggc?gtt?cac?tct?gcg?gtg?cgt?ctc 451

Glu?Ile?Arg?Gly?Val?Leu?Tyr?Val?Gly?Val?His?Ser?Ala?Val?Arg?Leu

105 110 115

ggc?gac?act?gtt?att?gaa?gaa?gtc?acc?atg?act?gcg?cgc?acg?ttg?gaa 499

Gly?Asp?Thr?Val?Ile?Glu?Glu?Val?Thr?Met?Thr?Ala?Arg?Thr?Leu?Glu

120 125 130

caa?aac?ctg?gcg?atc?aac?tcc?gcg?ctt?cgc?cgc?aat?ggc?gtt?cct?gat 547

Gln?Asn?Leu?Ala?Ile?Asn?Ser?Ala?Leu?Arg?Arg?Asn?Gly?Val?Pro?Asp

135 140 145

ggt?cgc?ggt?tcc?ctc?aaa?gct?aac?cgc?gtg?atg?aat?ggg?gcg?gag?tgg 595

Gly?Arg?Gly?Ser?Leu?Lys?Ala?Asn?Arg?Val?Met?Asn?Gly?Ala?Glu?Trp

150 155 160 165

gag?cag?gtt?cgt?tcc?act?cat?tcc?aag?ctg?cgc?atg?ctg?gca?aat?cgt 643

Glu?Gln?Val?Arg?Ser?Thr?His?Ser?Lys?Leu?Arg?Met?Leu?Ala?Asn?Arg

170 175 180

gtg?acc?gat?gag?gat?ctg?cgc?cgc?gat?ttg?gaa?gag?ctt?tgc?gat?cag 691

Val?Thr?Asp?Glu?Asp?Leu?Arg?Arg?Asp?Leu?Glu?Glu?Leu?Cys?Asp?Gln

185 190 195

atg?gtc?acc?cca?gtc?cgc?atc?aag?cag?acc?acc?aag?ctg?tcc?gcg?cgt 739

Met?Val?Thr?Pro?Val?Arg?Ile?Lys?Gln?Thr?Thr?Lys?Leu?Ser?Ala?Arg

200 205 210

gag?ttg?gac?gtg?ctg?gct?tgt?gtc?gcg?ctc?ggt?cac?acc?aac?gtc?gaa 787

Glu?Leu?Asp?Val?Leu?Ala?Cys?Val?Ala?Leu?Gly?His?Thr?Asn?Val?Glu

215 220 225

gct?gct?gaa?gag?atg?ggc?atc?ggc?gcg?gaa?acc?gtc?aag?agc?tac?ctg 835

Ala?Ala?Glu?Glu?Met?Gly?Ile?Gly?Ala?Glu?Thr?Val?Lys?Ser?Tyr?Leu

230 235 240 245

cgc?tcg?gtc?atg?cgc?aag?ctc?ggc?gcc?cac?acg?cgc?tac?gag?gca?gtc 883

Arg?Ser?Val?Met?Arg?Lys?Leu?Gly?Ala?His?Thr?Arg?Tyr?Glu?Ala?Val

250 255 260

aac?gca?gca?cgc?cgg?atc?ggc?gca?ctg?cct?taaaaagatt?ttgctttacg 933

Asn?Ala?Ala?Arg?Arg?Ile?Gly?Ala?Leu?Pro

265 270

acg 936

<210>296

<211>271

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>296

Met?Leu?Phe?Val?Arg?Arg?Leu?Thr?Ser?Leu?Lys?Thr?Ala?Thr?Gly?Ile

1 5 10 15

Pro?Val?Thr?Met?Phe?Ala?Thr?Val?Leu?Gln?Asp?Asn?Arg?Leu?Gln?Ile

20 25 30

Thr?Gln?Trp?Val?Gly?Leu?Arg?Thr?Pro?Ala?Leu?Gln?Asn?Leu?Val?Ile

35 40 45

Glu?Pro?Gly?Val?Gly?Val?Gly?Gly?Arg?Val?Val?Ala?Thr?Arg?Arg?Pro

50 55 60

Val?Gly?Val?Ser?Asp?Tyr?Thr?Arg?Ala?Asn?Val?Ile?Ser?His?Glu?Lys

65 70 75 80

Asp?Ser?Ala?Ile?Gln?Asp?Glu?Gly?Leu?His?Ser?Ile?Val?Ala?Val?Pro

85 90 95

Val?Ile?Val?His?Arg?Glu?Ile?Arg?Gly?Val?Leu?Tyr?Val?Gly?Val?His

100 105 110

Ser?Ala?Val?Arg?Leu?Gly?Asp?Thr?Val?Ile?Glu?Glu?Val?Thr?Met?Thr

115 120 125

Ala?Arg?Thr?Leu?Glu?Gln?Asn?Leu?Ala?Ile?Asn?Ser?Ala?Leu?Arg?Arg

130 135 140

Asn?Gly?Val?Pro?Asp?Gly?Arg?Gly?Ser?Leu?Lys?Ala?Asn?Arg?Val?Met

145 150 155 160

Asn?Gly?Ala?Glu?Trp?Glu?Gln?Val?Arg?Ser?Thr?His?Ser?Lys?Leu?Arg

165 170 175

Met?Leu?Ala?Asn?Arg?Val?Thr?Asp?Glu?Asp?Leu?Arg?Arg?Asp?Leu?Glu

180 185 190

Glu?Leu?Cys?Asp?Gln?Met?Val?Thr?Pro?Val?Arg?Ile?Lys?Gln?Thr?Thr

195 200 205

Lys?Leu?Ser?Ala?Arg?Glu?Leu?Asp?Val?Leu?Ala?Cys?Val?Ala?Leu?Gly

210 215 220

His?Thr?Asn?Val?Glu?Ala?Ala?Glu?Glu?Met?Gly?Ile?Gly?Ala?Glu?Thr

225 230 235 240

Val?Lys?Ser?Tyr?Leu?Arg?Ser?Val?Met?Arg?Lys?Leu?Gly?Ala?His?Thr

245 250 255

Arg?Tyr?Glu?Ala?Val?Asn?Ala?Ala?Arg?Arg?Ile?Gly?Ala?Leu?Pro

260 265 270

<210>297

<211>759

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(736)

<223>RXA00650

<400>297

aaggctagac?taaagtacga?ttcatctgct?catcgatact?cttgaaggcg?cattttcatt 60

cgaaacgaag?tgcgccattg?ggaaggacct?agttcaaaca?atg?att?cgc?gtg?ctg 115

Met?Ile?Arg?Val?Leu

1 5

ctt?gct?gat?gac?cac?gaa?atc?gtg?agg?ctc?gga?ctc?cga?gct?gtg?ctg 163

Leu?Ala?Asp?Asp?His?Glu?Ile?Val?Arg?Leu?Gly?Leu?Arg?Ala?Val?Leu

10 15 20

gaa?agc?gcc?gag?gac?att?gaa?gtg?gtg?ggc?gaa?gtc?tcc?acc?gcc?gaa 211

Glu?Ser?Ala?Glu?Asp?Ile?Glu?Val?Val?Gly?Glu?Val?Ser?Thr?Ala?Glu

25 30 35

ggt?gcg?gtg?cag?gca?gcc?caa?gaa?ggc?gga?atc?gac?gtc?atc?ttg?atg 259

Gly?Ala?Val?Gln?Ala?Ala?Gln?Glu?Gly?Gly?Ile?Asp?Val?Ile?Leu?Met

40 45 50

gac?ctc?cga?ttc?ggc?ccc?ggc?gtc?caa?gga?acc?cag?gtt?tcc?aca?ggc 307

Asp?Leu?Arg?Phe?Gly?Pro?Gly?Val?Gln?Gly?Thr?Gln?Val?Ser?Thr?Gly

55 60 65

gca?gac?gcc?acc?gca?gcc?atc?aag?cga?aac?atc?gat?aac?ccg?cca?aaa 355

Ala?Asp?Ala?Thr?Ala?Ala?Ile?Lys?Arg?Asn?Ile?Asp?Asn?Pro?Pro?Lys

70 75 80 85

gtc?ctg?gtc?gtg?acc?aac?tac?gac?acc?gac?aca?gac?atc?ctc?ggc?gca 403

Val?Leu?Val?Val?Thr?Asn?Tyr?Asp?Thr?Asp?Thr?Asp?Ile?Leu?Gly?Ala

90 95 100

atc?gaa?gcc?ggc?gca?ctg?ggc?tac?ctg?ctc?aaa?gac?gcc?cca?ccg?agc 451

Ile?Glu?Ala?Gly?Ala?Leu?Gly?Tyr?Leu?Leu?Lys?Asp?Ala?Pro?Pro?Ser

105 110 115

gaa?ctc?ctg?gca?gca?gta?cga?tcc?gca?gca?gaa?ggt?gac?tcc?aca?ctg 499

Glu?Leu?Leu?Ala?Ala?Val?Arg?Ser?Ala?Ala?Glu?Gly?Asp?Ser?Thr?Leu

120 125 130

tca?ccc?atg?gtt?gcg?aac?cgc?ctg?atg?act?cgc?gtg?cgc?acc?ccc?aaa 547

Ser?Pro?Met?Val?Ala?Asn?Arg?Leu?Met?Thr?Arg?Val?Arg?Thr?Pro?Lys

135 140 145

acc?tca?ctc?acc?cca?cgt?gaa?ctg?gaa?gtt?ctc?aag?ctg?gtt?gcc?ggt 595

Thr?Ser?Leu?Thr?Pro?Arg?Glu?Leu?Glu?Val?Leu?Lys?Leu?Val?Ala?Gly

150 155 160 165

gga?tcc?tcc?aac?cgc?gac?att?ggc?cgt?atc?ctc?ttc?ctc?tca?gaa?gcc 643

Gly?Ser?Ser?Asn?Arg?Asp?Ile?Gly?Arg?Ile?Leu?Phe?Leu?Ser?Glu?Ala

170 175 180

acg?gtg?aaa?tcc?cac?ctc?gtg?cac?atc?tac?gac?aag?ctc?ggc?gtg?cgg 691

Thr?Val?Lys?Ser?His?Leu?Val?His?Ile?Tyr?Asp?Lys?Leu?Gly?Val?Arg

185 190 195

tca?cgt?acc?tcc?gct?gtc?gca?gcc?gca?cgt?gag?cag?ggg?ctg?ctg 736

Ser?Arg?Thr?Ser?Ala?Val?Ala?Ala?Ala?Arg?Glu?Gln?Gly?Leu?Leu

200 205 210

tagcgggggt?tgctgcaagg?ctt 759

<210>298

<211>212

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>298

Met?Ile?Arg?Val?Leu?Leu?Ala?Asp?Asp?His?Glu?Ile?Val?Arg?Leu?Gly

1 5 10 15

Leu?Arg?Ala?Val?Leu?Glu?Ser?Ala?Glu?Asp?Ile?Glu?Val?Val?Gly?Glu

20 25 30

Val?Ser?Thr?Ala?Glu?Gly?Ala?Val?Gln?Ala?Ala?Gln?Glu?Gly?Gly?Ile

35 40 45

Asp?Val?Ile?Leu?Met?Asp?Leu?Arg?Phe?Gly?Pro?Gly?Val?Gln?Gly?Thr

50 55 60

Gln?Val?Ser?Thr?Gly?Ala?Asp?Ala?Thr?Ala?Ala?Ile?Lys?Arg?Asn?Ile

65 70 75 80

Asp?Asn?Pro?Pro?Lys?Val?Leu?Val?Val?Thr?Asn?Tyr?Asp?Thr?Asp?Thr

85 90 95

Asp?Ile?Leu?Gly?Ala?Ile?Glu?Ala?Gly?Ala?Leu?Gly?Tyr?Leu?Leu?Lys

100 105 110

Asp?Ala?Pro?Pro?Ser?Glu?Leu?Leu?Ala?Ala?Val?Arg?Ser?Ala?Ala?Glu

115 120 125

Gly?Asp?Ser?Thr?Leu?Ser?Pro?Met?Val?Ala?Asn?Arg?Leu?Met?Thr?Arg

130 135 140

Val?Arg?Thr?Pro?Lys?Thr?Ser?Leu?Thr?Pro?Arg?Glu?Leu?Glu?Val?Leu

145 150 155 160

Lys?Leu?Val?Ala?Gly?Gly?Ser?Ser?Asn?Arg?Asp?Ile?Gly?Arg?Ile?Leu

165 170 175

Phe?Leu?Ser?Glu?Ala?Thr?Val?Lys?Ser?His?Leu?Val?His?Ile?Tyr?Asp

180 185 190

Lys?Leu?Gly?Val?Arg?Ser?Arg?Thr?Ser?Ala?Val?Ala?Ala?Ala?Arg?Glu

195 200 205

Gln?Gly?Leu?Leu

210

<2l0>299

<211>655

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(24)..(632)

<223>RXA01189

<400>299

cacctgcaga?aaaggaagct?taa?atg?att?tcc?att?tcc?atc?gcc?gac?gac?gaa 53

Met?Ile?Ser?Ile?Ser?Ile?Ala?Asp?Asp?Glu

1 5 10

gcc?ctg?atc?gca?agc?tcc?ctg?gca?acc?ttg?ctc?agc?ttg?gaa?ccc?gat 101

Ala?Leu?Ile?Ala?Ser?Ser?Leu?Ala?Thr?Leu?Leu?Ser?Leu?Glu?Pro?Asp

15 20 25

tta?gac?gtc?cga?cct?acc?gca?gga?tcc?ggt?gaa?gaa?ctc?att?gaa?acg 149

Leu?Asp?Val?Arg?Pro?Thr?Ala?Gly?Ser?Gly?Glu?Glu?Leu?Ile?Glu?Thr

30 35 40

tgg?gcg?gat?cca?agc?aac?cga?acc?gat?gta?tgc?gtc?ctt?gac?ctt?caa 197

Trp?Ala?Asp?Pro?Ser?Asn?Arg?Thr?Asp?Val?Cys?Val?Leu?Asp?Leu?Gln

45 50 55

ctc?gga?ggc?atc?gac?ggc?atc?gac?acc?gcc?acc?cgg?ctc?atg?gaa?acc 245

Leu?Gly?Gly?Ile?Asp?Gly?Ile?Asp?Thr?Ala?Thr?Arg?Leu?Met?Glu?Thr

60 65 70

acc?cca?gat?ttg?gcc?gtg?ctc?atc?gtg?acc?agc?cac?gcc?agg?ccc?cga 293

Thr?Pro?Asp?Leu?Ala?Val?Leu?Ile?Val?Thr?Ser?His?Ala?Arg?Pro?Arg

75 80 85 90

caa?ctc?aaa?cgc?gcg?ctt?gca?gca?ggt?gtt?tta?gga?ttc?ttg?ccc?aaa 341

Gln?Leu?Lys?Arg?Ala?Leu?Ala?Ala?Gly?Val?Leu?Gly?Phe?Leu?Pro?Lys

95 100 105

aca?tcc?acc?gca?gat?gaa?ttc?gcc?acc?gca?atc?cgc?acc?gtt?cac?gct 389

Thr?Ser?Thr?Ala?Asp?Glu?Phe?Ala?Thr?Ala?Ile?Arg?Thr?Val?His?Ala

110 115 120

gga?cga?cgc?tac?atc?gac?ccc?gaa?cta?gcc?gcc?atg?acg?atc?agc?gcc 437

Gly?Arg?Arg?Tyr?Ile?Asp?Pro?Glu?Leu?Ala?Ala?Met?Thr?Ile?Ser?Ala

125 130 135

ggt?gaa?tcc?cca?tta?acc?aac?cgt?gaa?gaa?gaa?gtc?ctc?gaa?cta?gca 485

Gly?Glu?Ser?Pro?Leu?Thr?Asn?Arg?Glu?Glu?Glu?Val?Leu?Glu?Leu?Ala

140 145 150

ggc?caa?gga?cta?agc?gcc?gaa?gaa?att?gcg?gtg?gca?gcg?cac?ctc?gcg 533

Gly?Gln?Gly?Leu?Ser?Ala?Glu?Glu?Ile?Ala?Val?Ala?Ala?His?Leu?Ala

155 160 165 170

ccg?gga?acc?acc?cgc?aac?tat?tta?tcc?caa?gct?atg?aca?aaa?gta?ggc 581

Pro?Gly?Thr?Thr?Arg?Asn?Tyr?Leu?Ser?Gln?Ala?Met?Thr?Lys?Val?Gly

175 180 185

gcg?cag?aat?cgc?ttt?gaa?gcg?ttc?acg?cgc?gcc?agg?gaa?ttg?ggc?tgg 629

Ala?Gln?Asn?Arg?Phe?Glu?Ala?Phe?Thr?Arg?Ala?Arg?Glu?Leu?Gly?Trp

190 195 200

ttg?tagcttgtgg?cttatctcct?att 655

Leu

<210>300

<211>203

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>300

Met?Ile?Ser?Ile?Ser?Ile?Ala?Asp?Asp?Glu?Ala?Leu?Ile?Ala?Ser?Ser

1 5 10 15

Leu?Ala?Thr?Leu?Leu?Ser?Leu?Glu?Pro?Asp?Leu?Asp?Val?Arg?Pro?Thr

20 25 30

Ala?Gly?Ser?Gly?Glu?Glu?Leu?Ile?Glu?Thr?Trp?Ala?Asp?Pro?Ser?Asn

35 40 45

Arg?Thr?Asp?Val?Cys?Val?Leu?Asp?Leu?Gln?Leu?Gly?Gly?Ile?Asp?Gly

50 55 60

Ile?Asp?Thr?Ala?Thr?Arg?Leu?Met?Glu?Thr?Thr?Pro?Asp?Leu?Ala?Val

65 70 75 80

Leu?Ile?Val?Thr?Ser?His?Ala?Arg?Pro?Arg?Gln?Leu?Lys?Arg?Ala?Leu

85 90 95

Ala?Ala?Gly?Val?Leu?Gly?Phe?Leu?Pro?Lys?Thr?Ser?Thr?Ala?Asp?Glu

100 105 110

Phe?Ala?Thr?Ala?Ile?Arg?Thr?Val?His?Ala?Gly?Arg?Arg?Tyr?Ile?Asp

115 120 125

Pro?Glu?Leu?Ala?Ala?Met?Thr?Ile?Ser?Ala?Gly?Glu?Ser?Pro?Leu?Thr

130 135 140

Asn?Arg?Glu?Glu?Glu?Val?Leu?Glu?Leu?Ala?Gly?Gln?Gly?Leu?Ser?Ala

145 150 155 160

Glu?Glu?Ile?Ala?Val?Ala?Ala?His?Leu?Ala?Pro?Gly?Thr?Thr?Arg?Asn

165 170 175

Tyr?Leu?Ser?Gln?Ala?Met?Thr?Lys?Val?Gly?Ala?Gln?Asn?Arg?Phe?Glu

180 185 190

Ala?Phe?Thr?Arg?Ala?Arg?Glu?Leu?Gly?Trp?Leu

195 200

<210>301

<211>753

<2l2>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(730)

<223>RXA01607

<400>301

gggctgaagg?gctgggcgga?acaataatta?ttgaatctac?aatcggatcg?ggaactggaa 60

tttccgcccg?ttttccctat?ccacaaaagg?accaagataa?gtg?atc?cgt?att?ctg 115

Val?Ile?Arg?Ile?Leu

1 5

ttg?gct?gat?gat?cat?ccc?gtt?gtt?cgc?gca?ggc?ctt?gcc?tcc?ttg?ctg 163

Leu?Ala?Asp?Asp?His?Pro?Val?Val?Arg?Ala?Gly?Leu?Ala?Ser?Leu?Leu

10 15 20

gtg?agt?gaa?gat?gat?ttt?gag?ata?gtg?gac?atg?gtg?ggc?acc?cca?gat 211

Val?Ser?Glu?Asp?Asp?Phe?Glu?Ile?Val?Asp?Met?Val?Gly?Thr?Pro?Asp

25 30 35

gat?gcc?gtt?gcg?cgc?gcc?gcg?gaa?ggc?ggg?gtg?gat?gtg?gtg?ttg?atg 259

Asp?Ala?Val?Ala?Arg?Ala?Ala?Glu?Gly?Gly?Val?Asp?Val?Val?Leu?Met

40 45 50

gat?ctg?cgt?ttt?ggt?gat?caa?cca?ggc?atc?gag?gtc?gcc?ggc?ggg?gta 307

Asp?Leu?Arg?Phe?Gly?Asp?Gln?Pro?Gly?Ile?Glu?Val?Ala?Gly?Gly?Val

55 60 65

gag?gca?acg?cgt?cgc?atc?cgt?gcg?ctg?gac?aac?ccg?cca?cag?gta?ctg 355

Glu?Ala?Thr?Arg?Arg?Ile?Arg?Ala?Leu?Asp?Asn?Pro?Pro?Gln?Val?Leu

70 75 80 85

gtg?gtg?acc?aac?tac?tcc?aca?gac?ggc?gat?gtg?gtg?ggc?gca?gta?tct 403

Val?Val?Thr?Asn?Tyr?Ser?Thr?Asp?Gly?Asp?Val?Val?Gly?Ala?Val?Ser

90 95 100

gct?ggt?gcc?gtg?ggg?tat?ttg?ctc?aaa?gat?agc?tcc?cca?gaa?gat?ctc 451

Ala?Gly?Ala?Val?Gly?Tyr?Leu?Leu?Lys?Asp?Ser?Ser?Pro?Glu?Asp?Leu

105 110 115

att?gcc?ggt?gtt?cgc?gat?gcc?gcg?cgg?gga?gaa?tca?gtg?ctt?tca?aag 499

lle?Ala?Gly?Val?Arg?Asp?Ala?Ala?Arg?Gly?Glu?Ser?Val?Leu?Ser?Lys

120 125 130

cag?gtc?gcc?agc?aag?atc?atg?ggg?cgg?atg?aac?aac?ccc?atg?act?gct 547

Gln?Val?Ala?Ser?Lys?Ile?Met?Gly?Arg?Met?Asn?Asn?Pro?Met?Thr?Ala

135 140 145

ctc?agt?gcc?aga?gaa?att?gaa?gtg?ctg?tcc?ttg?gtg?gcg?caa?ggg?caa 595

Leu?Ser?Ala?Arg?Glu?Ile?Glu?Val?Leu?Ser?Leu?Val?Ala?Gln?Gly?Gln

150 155 160 165

agc?aat?aga?gaa?atc?ggc?aag?aaa?ctt?ttc?ctc?act?gag?gcc?acg?gtg 643

Ser?Asn?Arg?Glu?Ile?Gly?Lys?Lys?Leu?Phe?Leu?Thr?Glu?Ala?Thr?Val

170 175 180

aaa?agt?cac?atg?ggg?cat?gtg?ttc?aac?aag?ctg?gat?gtc?acc?tct?aga 691

Lys?Ser?His?Met?Gly?His?Val?Phe?Asn?Lys?Leu?Asp?Val?Thr?Ser?Arg

185 190 195

aca?gct?gcg?gta?gct?gaa?gcc?aga?cag?cgc?gga?att?atc?tagacgcaca 740

Thr?Ala?Ala?Val?Ala?Glu?Ala?Arg?Gln?Arg?Gly?Ile?Ile

200 205 210

cgtgttggta?acc 753

<210>302

<211>210

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>302

Val?Ile?Arg?Ile?Leu?Leu?Ala?Asp?Asp?His?Pro?Val?Val?Arg?Ala?Gly

1 5 10 15

Leu?Ala?Ser?Leu?Leu?Val?Ser?Glu?Asp?Asp?Phe?Glu?Ile?Val?Asp?Met

20 25 30

Val?Gly?Thr?Pro?Asp?Asp?Ala?Val?Ala?Arg?Ala?Ala?Glu?Gly?Gly?Val

35 40 45

Asp?Val?Val?Leu?Met?Asp?Leu?Arg?Phe?Gly?Asp?Gln?Pro?Gly?Ile?Glu

50 55 60

Val?Ala?Gly?Gly?Val?Glu?Ala?Thr?Arg?Arg?Ile?Arg?Ala?Leu?Asp?Asn

65 70 75 80

Pro?Pro?Gln?Val?Leu?Val?Val?Thr?Asn?Tyr?Ser?Thr?Asp?Gly?Asp?Val

85 90 95

Val?Gly?Ala?Val?Ser?Ala?Gly?Ala?Val?Gly?Tyr?Leu?Leu?Lys?Asp?Ser

100 105 110

Ser?Pro?Glu?Asp?Leu?Ile?Ala?Gly?Val?Arg?Asp?Ala?Ala?Arg?Gly?Glu

115 120 125

Ser?Val?Leu?Ser?Lys?Gln?Val?Ala?Ser?Lys?Ile?Met?Gly?Arg?Met?Asn

130 135 140

Asn?Pro?Met?Thr?Ala?Leu?Ser?Ala?Arg?Glu?Ile?Glu?Val?Leu?Ser?Leu

145 150 155 160

Val?Ala?Gln?Gly?Gln?Ser?Asn?Arg?Glu?Ile?Gly?Lys?Lys?Leu?Phe?Leu

165 170 175

Thr?Glu?Ala?Thr?Val?Lys?Ser?His?Met?Gly?His?Val?Phe?Asn?Lys?Leu

180 185 190

Asp?Val?Thr?Ser?Arg?Thr?Ala?Ala?Val?Ala?Glu?Ala?Arg?Gln?Arg?Gly

195 200 205

Ile?Ile

210

<210>303

<211>1392

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1369)

<223>RXN00470

<400>303

tcataaccag?gttgggcaaa?agggatgaat?ccctggttgt?ggtggggctc?ctgaaaagta 60

ctcatagact?ctattgtgga?gtgttgaggc?tgataagtga?atg?ggg?gaa?agc?cct 115

Met?Gly?Glu?Ser?Pro

1 5

gaa?aag?gtg?gcg?ttc?agg?gtc?ttc?cct?gat?ggt?ttg?gtg?tcg?cag?ggg 163

Glu?Lys?Val?Ala?Phe?Arg?Val?Phe?Pro?Asp?Gly?Leu?Val?Ser?Gln?Gly

10 15 20

cat?gac?atg?atc?gaa?gat?atg?agt?aac?aca?cct?gcg?cct?tat?acc?ccg 211

His?Asp?Met?Ile?Glu?Asp?Met?Ser?Asn?Thr?Pro?Ala?Pro?Tyr?Thr?Pro

25 30 35

cag?cct?gcg?ggg?caa?gcg?gtg?cct?tta?tat?ccc?acg?ttt?acc?cgg?tca 259

Gln?Pro?Ala?Gly?Gln?Ala?Val?Pro?Leu?Tyr?Pro?Thr?Phe?Thr?Arg?Ser

40 45 50

aga?gat?ggt?cgg?gtt?gtt?gcg?ggt?gtc?gca?tcg?ggg?ctg?gca?aag?cat 307

Arg?Asp?Gly?Arg?Val?Val?Ala?Gly?Val?Ala?Ser?Gly?Leu?Ala?Lys?His

55 60 65

ctt?aat?gtg?tcg?gtg?ttt?tgg?gtt?cgt?gcg?ctg?ctg?att?ttt?gcg?gcg 355

Leu?Asn?Val?Ser?Val?Phe?Trp?Val?Arg?Ala?Leu?Leu?Ile?Phe?Ala?Ala

70 75 80 85

ttg?ctg?agc?ggt?gcg?ggt?ctt?ttt?gcg?tat?gcc?ttg?att?tgg?att?ttt 403

Leu?Leu?Ser?Gly?Ala?Gly?Leu?Phe?Ala?Tyr?Ala?Leu?Ile?Trp?Ile?Phe

90 95 100

acg?cgc?att?gag?aaa?aag?ggg?agt?ggg?gag?gcg?tcg?aca?agc?aag?cgc 451

Thr?Arg?Ile?Glu?Lys?Lys?Gly?Ser?Gly?Glu?Ala?Ser?Thr?Ser?Lys?Arg

105 110 115

tgg?gtg?tcg?tgg?tgc?ctg?gtg?ctg?ctc?gct?atc?ggt?ggt?gct?gcg?gcg 499

Trp?Val?Ser?Trp?Cys?Leu?Val?Leu?Leu?Ala?Ile?Gly?Gly?Ala?Ala?Ala

120 125 130

tcg?gtg?atg?ctg?agc?acc?ggc?ttc?gcg?gtg?ggc?acg?ttg?gtg?ccc?atc 547

Ser?Val?Met?Leu?Ser?Thr?Gly?Phe?Ala?Val?Gly?Thr?Leu?Val?Pro?Ile

135 140 145

ggc?gtg?gtc?ggt?gtg?ggc?ctg?ttg?atg?gtg?tgg?ctg?gcg?tat?gac?cgc 595

Gly?Val?Val?Gly?Val?Gly?Leu?Leu?Met?Val?Trp?Leu?Ala?Tyr?Asp?Arg

150 155 160 165

ggg?gtg?gaa?tcc?ggc?ccg?aat?ctg?ctg?att?att?gcc?acc?ggc?ggt?gtg 643

Gly?Val?Glu?Ser?Gly?Pro?Asn?Leu?Leu?Ile?Ile?Ala?Thr?Gly?Gly?Val

170 175 180

ttg?atg?ctg?gtg?gcg?atc?gtg?ctg?atc?gtg?atg?aat?tgg?aac?acc?cag 691

Leu?Met?Leu?Val?Ala?Ile?Val?Leu?Ile?Val?Met?Asn?Trp?Asn?Thr?Gln

185 190 195

gac?ggc?ttc?gtc?atg?gcg?ctg?gtg?gcc?gtg?gtg?ctc?acg?ctg?gtg?ggt 739

Asp?Gly?Phe?Val?Met?Ala?Leu?Val?Ala?Val?Val?Leu?Thr?Leu?Val?Gly

200 205 210

gtg?gct?gcg?ctg?ggc?gtt?ccg?ctg?tgg?gtg?cgg?atg?tgg?gat?cag?ctg 787

Val?Ala?Ala?Leu?Gly?Val?Pro?Leu?Trp?Val?Arg?Met?Trp?Asp?Gln?Leu

215 220 225

ggc?gag?gag?cgc?gcg?gaa?aaa?gcc?gca?gct?gct?gag?cgc?gca?gat?att 835

Gly?Glu?Glu?Arg?Ala?Glu?Lys?Ala?Ala?Ala?Ala?Glu?Arg?Ala?Asp?Ile

230 235 240 245

gct?tcc?cgc?ctg?cat?gat?tcg?gta?ctg?cag?acc?ttg?gcg?ctg?att?caa 883

Ala?Ser?Arg?Leu?His?Asp?Ser?Val?Leu?Gln?Thr?Leu?Ala?Leu?Ile?Gln

250 255 260

aag?cgt?gcc?gac?gac?ccc?gcc?gaa?gtc?gcc?cgc?ctg?gcc?cgc?ggg?cag 931

Lys?Arg?Ala?Asp?Asp?Pro?Ala?Glu?Val?Ala?Arg?Leu?Ala?Arg?Gly?Gln

265 270 275

gaa?cgc?gag?ctg?cgt?caa?tgg?ctg?ttt?gat?tcc?caa?gat?aaa?aca?cct 979

Glu?Arg?Glu?Leu?Arg?Gln?Trp?Leu?Phe?Asp?Ser?Gln?Asp?Lys?Thr?Pro

280 285 290

caa?aca?acc?ggc?act?gtc?ttt?act?gcg?ttg?gag?cgc?gcc?tgc?ggt?gaa 1027

Gln?Thr?Thr?Gly?Thr?Val?Phe?Thr?Ala?Leu?Glu?Arg?Ala?Cys?Gly?Glu

295 300 305

gtc?gag?gat?att?tac?gct?ctg?cgt?atc?gtg?cct?gtg?acc?gtg?gga?acc 1075

Val?Glu?Asp?Ile?Tyr?Ala?Leu?Arg?Ile?Val?Pro?Val?Thr?Val?Gly?Thr

310 315 320 325

gat?gaa?gcg?ctg?act?gag?aaa?acg?cag?gca?gcg?gtg?atg?gca?gtc?cgc 1123

Asp?Glu?Ala?Leu?Thr?Glu?Lys?Thr?Gln?Ala?Ala?Val?Met?Ala?Val?Arg

330 335 340

gaa?gca?ctc?gtg?aac?gtg?gcc?aag?cat?gcc?ggc?gtg?gaa?acc?gcc?gat 1171

Glu?Ala?Leu?Val?Asn?Val?Ala?Lys?His?Ala?Gly?Val?Glu?Thr?Ala?Asp

345 350 355

gtg?tac?gcc?gaa?att?atg?ctc?ggc?gaa?ctg?aac?att?ttc?gtc?cgc?gac 1219

Val?Tyr?Ala?Glu?Ile?Met?Leu?Gly?Glu?Leu?Asn?Ile?Phe?Val?Arg?Asp

360 365 370

cgc?ggt?gca?gga?ttc?gac?ccc?gac?aac?atc?ccc?gac?ggg?cac?cac?ggg 1267

Arg?Gly?Ala?Gly?Phe?Asp?Pro?Asp?Asn?Ile?Pro?Asp?Gly?His?His?Gly

375 380 385

ctc?gcc?gaa?tcc?gtc?caa?ggc?cgc?gtc?gaa?cga?gcc?ggc?gga?aaa?gta 1315

Leu?Ala?Glu?Ser?Val?Gln?Gly?Arg?Val?Glu?Arg?Ala?Gly?Gly?Lys?Val

390 395 400 405

cgc?atc?aaa?tct?gaa?atc?ggc?gaa?ggc?acc?gaa?gtg?gca?atc?acc?atg 1363

Arg?Ile?Lys?Ser?Glu?Ile?Gly?Glu?Gly?Thr?Glu?Val?Ala?Ile?Thr?Met

410 415 420

gat?gtg?tagttggtcg?tacgcgcgtg?tct 1392

Asp?Val

<210>304

<211>423

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>304

Met?Gly?Glu?Ser?Pro?Glu?Lys?Val?Ala?Phe?Arg?Val?Phe?Pro?Asp?Gly

1 5 10 15

Leu?Val?Ser?Gln?Gly?His?Asp?Met?Ile?Glu?Asp?Met?Ser?Asn?Thr?Pro

20 25 30

Ala?Pro?Tyr?Thr?Pro?Gln?Pro?Ala?Gly?Gln?Ala?Val?Pro?Leu?Tyr?Pro

35 40 45

Thr?Phe?Thr?Arg?Ser?Arg?Asp?Gly?Arg?Val?Val?Ala?Gly?Val?Ala?Ser

50 55 60

Gly?Leu?Ala?Lys?His?Leu?Asn?Val?Ser?Val?Phe?Trp?Val?Arg?Ala?Leu

65 70 75 80

Leu?Ile?Phe?Ala?Ala?Leu?Leu?Ser?Gly?Ala?Gly?Leu?Phe?Ala?Tyr?Ala

85 90 95

Leu?Ile?Trp?Ile?Phe?Thr?Arg?Ile?Glu?Lys?Lys?Gly?Ser?Gly?Glu?Ala

100 105 110

Ser?Thr?Ser?Lys?Arg?Trp?Val?Ser?Trp?Cys?Leu?Val?Leu?Leu?Ala?Ile

115 120 125

Gly?Gly?Ala?Ala?Ala?Ser?Val?Met?Leu?Ser?Thr?Gly?Phe?Ala?Val?Gly

130 135 140

Thr?Leu?Val?Pro?Ile?Gly?Val?Val?Gly?Val?Gly?Leu?Leu?Met?Val?Trp

145 150 155 160

Leu?Ala?Tyr?Asp?Arg?Gly?Val?Glu?Ser?Gly?Pro?Asn?Leu?Leu?Ile?Ile

165 170 175

Ala?Thr?Gly?Gly?Val?Leu?Met?Leu?Val?Ala?Ile?Val?Leu?Ile?Val?Met

180 185 190

Asn?Trp?Asn?Thr?Gln?Asp?Gly?Phe?Val?Met?Ala?Leu?Val?Ala?Val?Val

195 200 205

Leu?Thr?Leu?Val?Gly?Val?Ala?Ala?Leu?Gly?Val?Pro?Leu?Trp?Val?Arg

210 215 220

Met?Trp?Asp?Gln?Leu?Gly?Glu?Glu?Arg?Ala?Glu?Lys?Ala?Ala?Ala?Ala

225 230 235 240

Glu?Arg?Ala?Asp?Ile?Ala?Ser?Arg?Leu?His?Asp?Ser?Val?Leu?Gln?Thr

245 250 255

Leu?Ala?Leu?Ile?Gln?Lys?Arg?Ala?Asp?Asp?Pro?Ala?Glu?Val?Ala?Arg

260 265 270

Leu?Ala?Arg?Gly?Gln?Glu?Arg?Glu?Leu?Arg?Gln?Trp?Leu?Phe?Asp?Ser

275 280 285

Gln?Asp?Lys?Thr?Pro?Gln?Thr?Thr?Gly?Thr?Val?Phe?Thr?Ala?Leu?Glu

290 295 300

Arg?Ala?Cys?Gly?Glu?Val?Glu?Asp?Ile?Tyr?Ala?Leu?Arg?Ile?Val?Pro

305 310 315 320

Val?Thr?Val?Gly?Thr?Asp?Glu?Ala?Leu?Thr?Glu?Lys?Thr?Gln?Ala?Ala

325 330 335

Val?Met?Ala?Val?Arg?Glu?Ala?Leu?Val?Asn?Val?Ala?Lys?His?Ala?Gly

340 345 350

Val?Glu?Thr?Ala?Asp?Val?Tyr?Ala?Glu?Ile?Met?Leu?Gly?Glu?Leu?Asn

355 360 365

Ile?Phe?Val?Arg?Asp?Arg?Gly?Ala?Gly?Phe?Asp?Pro?Asp?Asn?Ile?Pro

370 375 380

Asp?Gly?His?His?Gly?Leu?Ala?Glu?Ser?Val?Gln?Gly?Arg?Val?Glu?Arg

385 390 395 400

Ala?Gly?Gly?Lys?Val?Arg?Ile?Lys?Ser?Glu?Ile?Gly?Glu?Gly?Thr?Glu

405 410 415

Val?Ala?Ile?Thr?Met?Asp?Val

420

<210>305

<211>1323

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1300)

<223>FRXA00470

<400>305

tctattgtgg?agtgttgagg?ctgataagtg?aatgggggaa?agccctgaaa?aggtggcgtt 60

cagggtcttc?cctgatggtt?tggtgtcgca?ggggcatgac?atg?atc?gaa?gat?atg 115

Met?Ile?Glu?Asp?Met

1 5

agt?aac?aca?cct?gcg?cct?tat?acc?ccg?cag?cct?gcg?ggg?caa?gcg?gtg 163

Ser?Asn?Thr?Pro?Ala?Pro?Tyr?Thr?Pro?Gln?Pro?Ala?Gly?Gln?Ala?Val

10 15 20

cct?tta?tat?ccc?acg?ttt?acc?cgg?tca?aga?gat?ggt?cgg?gtt?gtt?gcg 211

Pro?Leu?Tyr?Pro?Thr?Phe?Thr?Arg?Ser?Arg?Asp?Gly?Arg?Val?Val?Ala

25 30 35

ggt?gtc?gca?tcg?ggg?ctg?gca?aag?cat?ctt?aat?gtg?tcg?gtg?ttt?tgg 259

Gly?Val?Ala?Ser?Gly?Leu?Ala?Lys?His?Leu?Asn?Val?Ser?Val?Phe?Trp

40 45 50

gtt?cgt?gcg?ctg?ctg?att?ttt?gcg?gcg?ttg?ctg?agc?ggt?gcg?ggt?ctt 307

Val?Arg?Ala?Leu?Leu?Ile?Phe?Ala?Ala?Leu?Leu?Ser?Gly?Ala?Gly?Leu

55 60 65

ttt?gcg?tat?gcc?ttg?att?tgg?att?ttt?acg?cgc?att?gag?aaa?aag?ggg 355

Phe?Ala?Tyr?Ala?Leu?Ile?Trp?Ile?Phe?Thr?Arg?Ile?Glu?Lys?Lys?Gly

70 75 80 85

agt?ggg?gag?gcg?tcg?aca?agc?aag?cgc?tgg?gtg?tcg?tgg?tgc?ctg?gtg 403

Ser?Gly?Glu?Ala?Ser?Thr?Ser?Lys?Arg?Trp?Val?Ser?Trp?Cys?Leu?Val

90 95 100

ctg?ctc?gct?atc?ggt?ggt?gct?gcg?gcg?tcg?gtg?atg?ctg?agc?acc?ggc 451

Leu?Leu?Ala?Ile?Gly?Gly?Ala?Ala?Ala?Ser?Val?Met?Leu?Ser?Thr?Gly

105 110 115

ttc?gcg?gtg?ggc?acg?ttg?gtg?ccc?atc?ggc?gtg?gtc?ggt?gtg?ggc?ctg 499

Phe?Ala?Val?Gly?Thr?Leu?Val?Pro?Ile?Gly?Val?Val?Gly?Val?Gly?Leu

120 125 130

ttg?atg?gtg?tgg?ctg?gcg?tat?gac?cgc?ggg?gtg?gaa?tcc?ggc?ccg?aat 547

Leu?Met?Val?Trp?Leu?Ala?Tyr?Asp?Arg?Gly?Val?Glu?Ser?Gly?Pro?Asn

135 140 145

ctg?ctg?att?att?gcc?acc?ggc?ggt?gtg?ttg?atg?ctg?gtg?gcg?atc?gtg 595

Leu?Leu?Ile?Ile?Ala?Thr?Gly?Gly?Val?Leu?Met?Leu?Val?Ala?Ile?Val

150 155 160 165

ctg?atc?gtg?atg?aat?tgg?aac?acc?cag?gac?ggc?ttc?gtc?atg?gcg?ctg 643

Leu?Ile?Val?Met?Asn?Trp?Asn?Thr?Gln?Asp?Gly?Phe?Val?Met?Ala?Leu

170 175 180

gtg?gcc?gtg?gtg?ctc?acg?ctg?gtg?ggt?gtg?gct?gcg?ctg?ggc?gtt?ccg 691

Val?Ala?Val?Val?Leu?Thr?Leu?Val?Gly?Val?Ala?Ala?Leu?Gly?Val?Pro

185 190 195

ctg?tgg?gtg?cgg?atg?tgg?gat?cag?ctg?ggc?gag?gag?cgc?gcg?gaa?aaa 739

Leu?Trp?Val?Arg?Met?Trp?Asp?Gln?Leu?Gly?Glu?Glu?Arg?Ala?Glu?Lys

200 205 210

gcc?gca?gct?gct?gag?cgc?gca?gat?att?gct?tcc?cgc?ctg?cat?gat?tcg 787

Ala?Ala?Ala?Ala?Glu?Arg?Ala?Asp?Ile?Ala?Ser?Arg?Leu?His?Asp?Ser

215 220 225

gta?ctg?cag?acc?ttg?gcg?ctg?att?caa?aag?cgt?gcc?gac?gac?ccc?gcc 835

Val?Leu?Gln?Thr?Leu?Ala?Leu?Ile?Gln?Lys?Arg?Ala?Asp?Asp?Pro?Ala

230 235 240 245

gaa?gtc?gcc?cgc?ctg?gcc?cgc?ggg?cag?gaa?cgc?gag?ctg?cgt?caa?tgg 883

Glu?Val?Ala?Arg?Leu?Ala?Arg?Gly?Gln?Glu?Arg?Glu?Leu?Arg?Gln?Trp

250 255 260

ctg?ttt?gat?tcc?caa?gat?aaa?aca?cct?caa?aca?acc?ggc?act?gtc?ttt 931

Leu?Phe?Asp?Ser?Gln?Asp?Lys?Thr?Pro?Gln?Thr?Thr?Gly?Thr?Val?Phe

265 270 275

act?gcg?ttg?gag?cgc?gcc?tgc?ggt?gaa?gtc?gag?gat?att?tac?gct?ctg 979

Thr?Ala?Leu?Glu?Arg?Ala?Cys?Gly?Glu?Val?Glu?Asp?Ile?Tyr?Ala?Leu

280 285 290

cgt?atc?gtg?cct?gtg?acc?gtg?gga?acc?gat?gaa?gcg?ctg?act?gag?aaa 1027

Arg?Ile?Val?Pro?Val?Thr?Val?Gly?Thr?Asp?Glu?Ala?Leu?Thr?Glu?Lys

295 300 305

acg?cag?gca?gcg?gtg?atg?gca?gtc?cgc?gaa?gca?ctc?gtg?aac?gtg?gcc 1075

Thr?Gln?Ala?Ala?Val?Met?Ala?Val?Arg?Glu?Ala?Leu?Val?Asn?Val?Ala

310 315 320 325

aag?cat?gcc?ggc?gtg?gaa?acc?gcc?gat?gtg?tac?gcc?gaa?att?atg?ctc 1123

Lys?His?Ala?Gly?Val?Glu?Thr?Ala?Asp?Val?Tyr?Ala?Glu?Ile?Met?Leu

330 335 340

ggc?gaa?ctg?aac?att?ttc?gtc?cgc?gac?cgc?ggt?gca?gga?ttc?gac?ccc 1171

Gly?Glu?Leu?Asn?Ile?Phe?Val?Arg?Asp?Arg?Gly?Ala?Gly?Phe?Asp?Pro

345 350 355

gac?aac?atc?ccc?gac?ggg?cac?cac?ggg?ctc?gcc?gaa?tcc?gtc?caa?ggc 1219

Asp?Asn?Ile?Pro?Asp?Gly?His?His?Gly?Leu?Ala?Glu?Ser?Val?Gln?Gly

360 365 370

cgc?gtc?gaa?cga?gcc?ggc?gga?aaa?gta?cgc?atc?aaa?tct?gaa?atc?ggc 1267

Arg?Val?Glu?Arg?Ala?Gly?Gly?Lys?Val?Arg?Ile?Lys?Ser?Glu?Ile?Gly

375 380 385

gaa?ggc?acc?gaa?gtg?gca?atc?acc?atg?gat?gtg?tagttggtcg?tacgcgcgtg 1320

Glu?Gly?Thr?Glu?Val?Ala?Ile?Thr?Met?Asp?Val

390 395 400

tct

1323

<210>306

<211>400

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>306

Met?Ile?Glu?Asp?Met?Ser?Asn?Thr?Pro?Ala?Pro?Tyr?Thr?Pro?Gln?Pro

1 5 10 15

Ala?Gly?Gln?Ala?Val?Pro?Leu?Tyr?Pro?Thr?Phe?Thr?Arg?Ser?Arg?Asp

20 25 30

Gly?Arg?Val?Val?Ala?Gly?Val?Ala?Ser?Gly?Leu?Ala?Lys?His?Leu?Asn

35 40 45

Val?Ser?Val?Phe?Trp?Val?Arg?Ala?Leu?Leu?Ile?Phe?Ala?Ala?Leu?Leu

50 55 60

Ser?Gly?Ala?Gly?Leu?Phe?Ala?Tyr?Ala?Leu?Ile?Trp?Ile?Phe?Thr?Arg

65 70 75 80

Ile?Glu?Lys?Lys?Gly?Ser?Gly?Glu?Ala?Ser?Thr?Ser?Lys?Arg?Trp?Val

85 90 95

Ser?Trp?Cys?Leu?Val?Leu?Leu?Ala?Ile?Gly?Gly?Ala?Ala?Ala?Ser?Val

100 105 110

Met?Leu?Ser?Thr?Gly?Phe?Ala?Val?Gly?Thr?Leu?Val?Pro?Ile?Gly?Val

115 120 125

Val?Gly?Val?Gly?Leu?Leu?Met?Val?Trp?Leu?Ala?Tyr?Asp?Arg?Gly?Val

130 135 140

Glu?Ser?Gly?Pro?Asn?Leu?Leu?Ile?Ile?Ala?Thr?Gly?Gly?Val?Leu?Met

145 150 155 160

Leu?Val?Ala?Ile?Val?Leu?Ile?Val?Met?Asn?Trp?Asn?Thr?Gln?Asp?Gly

165 170 175

Phe?Val?Met?Ala?Leu?Val?Ala?Val?Val?Leu?Thr?Leu?Val?Gly?Val?Ala

180 185 190

Ala?Leu?Gly?Val?Pro?Leu?Trp?Val?Arg?Met?Trp?Asp?Gln?Leu?Gly?Glu

195 200 205

Glu?Arg?Ala?Glu?Lys?Ala?Ala?Ala?Ala?Glu?Arg?Ala?Asp?Ile?Ala?Ser

210 215 220

Arg?Leu?His?Asp?Ser?Val?Leu?Gln?Thr?Leu?Ala?Leu?Ile?Gln?Lys?Arg

225 230 235 240

Ala?Asp?Asp?Pro?Ala?Glu?Val?Ala?Arg?Leu?Ala?Arg?Gly?Gln?Glu?Arg

245 250 255

Glu?Leu?Arg?Gln?Trp?Leu?Phe?Asp?Ser?Gln?Asp?Lys?Thr?Pro?Gln?Thr

260 265 270

Thr?Gly?Thr?Val?Phe?Thr?Ala?Leu?Glu?Arg?Ala?Cys?Gly?Glu?Val?Glu

275 280 285

Asp?Ile?Tyr?Ala?Leu?Arg?Ile?Val?Pro?Val?Thr?Val?Gly?Thr?Asp?Glu

290 295 300

Ala?Leu?Thr?Glu?Lys?Thr?Gln?Ala?Ala?Val?Met?Ala?Val?Arg?Glu?Ala

305 310 315 320

Leu?Val?Asn?Val?Ala?Lys?His?Ala?Gly?Val?Glu?Thr?Ala?Asp?Val?Tyr

325 330 335

Ala?Glu?Ile?Met?Leu?Gly?Glu?Leu?Asn?Ile?Phe?Val?Arg?Asp?Arg?Gly

340 345 350

Ala?Gly?Phe?Asp?Pro?Asp?Asn?Ile?Pro?Asp?Gly?His?His?Gly?Leu?Ala

355 360 365

Glu?Ser?Val?Gln?Gly?Arg?Val?Glu?Arg?Ala?Gly?Gly?Lys?Val?Arg?Ile

370 375 380

Lys?Ser?Glu?Ile?Gly?Glu?Gly?Thr?Glu?Val?Ala?Ile?Thr?Met?Asp?Val

385 390 395 400

<210>307

<211>1119

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1096)

<223>RXA00756

<400>307

attcgctaaa?cctgcgcagg?atgagactgc?cctcgcagaa?agcacattcg?acgaagccac 60

cgcgtaaaca?gtacgtggtg?gaagcttgag?aggaagacaa?gtg?aat?att?gat?gtc 115

Val?Asn?Ile?Asp?Val

1 5

cag?gct?tta?aaa?gcc?atc?gag?tct?gaa?aaa?gga?atc?cca?gtt?cca?gac 163

Gln?Ala?Leu?Lys?Ala?Ile?Glu?Ser?Glu?Lys?Gly?Ile?Pro?Val?Pro?Asp

10 15 20

ttg?ctg?cgc?acc?atc?gcc?tct?gca?ctt?ttg?cat?tcg?tac?atg?gat?aat 211

Leu?Leu?Arg?Thr?Ile?Ala?Ser?Ala?Leu?Leu?His?Ser?Tyr?Met?Asp?Asn

25 30 35

cgc?gaa?act?gtt?gcg?tct?gcg?aac?ctg?aaa?cca?cgc?gtg?gac?atc?gat 259

Arg?Glu?Thr?Val?Ala?Ser?Ala?Asn?Leu?Lys?Pro?Arg?Val?Asp?Ile?Asp

40 45 50

tcc?aca?act?ggc?acg?gtc?aac?gtc?atc?gtc?tca?gaa?ttc?gac?gaa?aac 307

Ser?Thr?Thr?Gly?Thr?Val?Asn?Val?Ile?Val?Ser?Glu?Phe?Asp?Glu?Asn

55 60 65

gga?gag?ctc?gct?tcc?gaa?tac?gac?gac?acc?cca?tcc?aac?ttc?gga?cga 355

Gly?Glu?Leu?Ala?Ser?Glu?Tyr?Asp?Asp?Thr?Pro?Ser?Asn?Phe?Gly?Arg

70 75 80 85

gtc?agc?gcc?cgc?gct?gtt?cgc?gac?gcg?atc?gtt?aag?tcc?ctg?cgc?gaa 403

Val?Ser?Ala?Arg?Ala?Val?Arg?Asp?Ala?Ile?Val?Lys?Ser?Leu?Arg?Glu

90 95 100

gca?gaa?gca?agc?cga?gca?ttc?gat?gcg?tac?gca?gat?tat?gaa?ggc?acc 451

Ala?Glu?Ala?Ser?Arg?Ala?Phe?Asp?Ala?Tyr?Ala?Asp?Tyr?Glu?Gly?Thr

105 110 115

gtt?gtg?tcc?ggc?atc?gtt?caa?gca?gat?gcc?cgc?gca?gct?gaa?cgc?gga 499

Val?Val?Ser?Gly?Ile?Val?Gln?Ala?Asp?Ala?Arg?Ala?Ala?Glu?Arg?Gly

120 125 130

atc?atc?atc?gtg?cag?ctg?ggt?acc?gaa?gcg?gac?aac?caa?gac?ggc?gtt 547

Ile?Ile?Ile?Val?Gln?Leu?Gly?Thr?Glu?Ala?Asp?Asn?Gln?Asp?Gly?Val

135 140 145

ttg?ctc?cca?gcc?gag?cag?atc?cct?ggc?gaa?aag?ctc?aag?cac?ggc?gac 595

Leu?Leu?Pro?Ala?Glu?Gln?Ile?Pro?Gly?Glu?Lys?Leu?Lys?His?Gly?Asp

150 155 160 165

cgc?gtc?aag?tgc?ttc?gtc?gtt?ggc?gtg?ggc?aag?ggc?aac?act?gac?atc 643

Arg?Val?Lys?Cys?Phe?Val?Val?Gly?Val?Gly?Lys?Gly?Asn?Thr?Asp?Ile

170 175 180

cag?atc?aac?ctg?tct?cgt?act?cac?cct?gag?ctg?gtg?cgc?cga?ctg?ttt 691

Gln?Ile?Asn?Leu?Ser?Arg?Thr?His?Pro?Glu?Leu?Val?Arg?Arg?Leu?Phe

185 190 195

gaa?ctg?gaa?atc?cca?gaa?gtt?gct?gac?gga?tcc?gtg?gaa?att?gtt?gct 739

Glu?Leu?Glu?Ile?Pro?Glu?Val?Ala?Asp?Gly?Ser?Val?Glu?Ile?Val?Ala

200 205 210

atc?tcc?cgc?gaa?gcc?gga?cac?cgc?tcc?aag?gtt?gct?gtt?caa?gcc?aag 787

Ile?Ser?Arg?Glu?Ala?Gly?His?Arg?Ser?Lys?Val?Ala?Val?Gln?Ala?Lys

215 220 225

gtg?aag?aac?ctc?aac?gcc?aag?ggc?gct?tgc?att?ggc?cca?cgt?gga?cag 835

Val?Lys?Asn?Leu?Asn?Ala?Lys?Gly?Ala?Cys?Ile?Gly?Pro?Arg?Gly?Gln

230 235 240 245

cgt?gtg?tcc?aac?atc?atg?cgt?gaa?ctc?ggt?gga?gaa?aaa?atc?gac?atc 883

Arg?Val?Ser?Asn?Ile?Met?Arg?Glu?Leu?Gly?Gly?Glu?Lys?Ile?Asp?Ile

250 255 260

atc?gat?tac?tcc?gaa?gat?cca?gca?acc?ttc?gtt?gga?aat?gca?ctg?gca 931

Ile?Asp?Tyr?Ser?Glu?Asp?Pro?Ala?Thr?Phe?Val?Gly?Asn?Ala?Leu?Ala

265 270 275

cca?tcc?aag?gtt?gtc?aac?gta?gag?gtc?acc?gat?ctt?gaa?gct?caa?acc 979

Pro?Ser?Lys?Val?Val?Asn?Val?Glu?Val?Thr?Asp?Leu?Glu?Ala?Gln?Thr

280 285 290

gcg?cgc?gta?act?gtc?cct?gac?tac?cag?ctt?tca?cta?gca?atc?ggt?aaa 1027

Ala?Arg?Val?Thr?Val?Pro?Asp?Tyr?Gln?Leu?Ser?Leu?Ala?lle?Gly?Lys

295 300 305

gaa?ggt?caa?aac?gcc?cgc?ttg?gct?gcc?cgc?ctg?acc?ggc?tgg?aag?atc 1075

Glu?Gly?Gln?Asn?Ala?Arg?Leu?Ala?Ala?Arg?Leu?Thr?Gly?Trp?Lys?Ile

310 315 320 325

gac?atc?cac?tct?gac?atc?gat?taaaagtcgc?ttgaaccggc?atg 1119

Asp?Ile?His?Ser?Asp?Ile?Asp

330

<210>308

<211>332

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>308

Val?Asn?Ile?Asp?Val?Gln?Ala?Leu?Lys?Ala?Ile?Glu?Ser?Glu?Lys?Gly

1 5 10 15

Ile?Pro?Val?Pro?Asp?Leu?Leu?Arg?Thr?Ile?Ala?Ser?Ala?Leu?Leu?His

20 25 30

Ser?Tyr?Met?Asp?Asn?Arg?Glu?Thr?Val?Ala?Ser?Ala?Asn?Leu?Lys?Pro

35 40 45

Arg?Val?Asp?Ile?Asp?Ser?Thr?Thr?Gly?Thr?Val?Asn?Val?Ile?Val?Ser

50 55 60

Glu?Phe?Asp?Glu?Asn?Gly?Glu?Leu?Ala?Ser?Glu?Tyr?Asp?Asp?Thr?Pro

65 70 75 80

Ser?Asn?Phe?Gly?Arg?Val?Ser?Ala?Arg?Ala?Val?Arg?Asp?Ala?Ile?Val

85 90 95

Lys?Ser?Leu?Arg?Glu?Ala?Glu?Ala?Ser?Arg?Ala?Phe?Asp?Ala?Tyr?Ala

100 105 110

Asp?Tyr?Glu?Gly?Thr?Val?Val?Ser?Gly?Ile?Val?Gln?Ala?Asp?Ala?Arg

115 120 125

Ala?Ala?Glu?Arg?Gly?Ile?Ile?Ile?Val?Gln?Leu?Gly?Thr?Glu?Ala?Asp

130 135 140

Asn?Gln?Asp?Gly?Val?Leu?Leu?Pro?Ala?Glu?Gln?Ile?Pro?Gly?Glu?Lys

145 150 155 160

Leu?Lys?His?Gly?Asp?Arg?Val?Lys?Cys?Phe?Val?Val?Gly?Val?Gly?Lys

165 170 175

Gly?Asn?Thr?Asp?Ile?Gln?Ile?Asn?Leu?Ser?Arg?Thr?His?Pro?Glu?Leu

180 185 190

Val?Arg?Arg?Leu?Phe?Glu?Leu?Glu?Ile?Pro?Glu?Val?Ala?Asp?Gly?Ser

195 200 205

Val?Glu?Ile?Val?Ala?Ile?Ser?Arg?Glu?Ala?Gly?His?Arg?Ser?Lys?Val

210 215 220

Ala?Val?Gln?Ala?Lys?Val?Lys?Asn?Leu?Asn?Ala?Lys?Gly?Ala?Cys?Ile

225 230 235 240

Gly?Pro?Arg?Gly?Gln?Arg?Val?Ser?Asn?Ile?Met?Arg?Glu?Leu?Gly?Gly

245 250 255

Glu?Lys?Ile?Asp?Ile?Ile?Asp?Tyr?Ser?Glu?Asp?Pro?Ala?Thr?Phe?Val

260 265 270

Gly?Asn?Ala?Leu?Ala?Pro?Ser?Lys?Val?Val?Asn?Val?Glu?Val?Thr?Asp

275 280 285

Leu?Glu?Ala?Gln?Thr?Ala?Arg?Val?Thr?Val?Pro?Asp?Tyr?Gln?Leu?Ser

290 295 300

Leu?Ala?Ile?Gly?Lys?Glu?Gly?Gln?Asn?Ala?Arg?Leu?Ala?Ala?Arg?Leu

305 310 315 320

Thr?Gly?Trp?Lys?Ile?Asp?Ile?His?Ser?Asp?Ile?Asp

325 330

<210>309

<211>834

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(811)

<223>RXA00139

<400>309

gaccggaaac?gtactcaagg?tagacacccg?cgacggttcc?tacctctccc?gcgttaacaa 60

ctaagattct?taaaaccttt?aagaatcagc?cagaaacatt?ttg?att?gaa?cag?gaa 115

Leu?Ile?Gln?Gln?Glu

1 5

caa?aga?gaa?caa?aac?gtg?agc?gag?cgt?cga?caa?gat?tac?aag?cga?cac 163

Gln?Arg?Glu?Gln?Asn?Val?Ser?Glu?Arg?Arg?Gln?Asp?Tyr?Lys?Arg?His

10 15 20

gga?tcc?cgc?tac?aag?gcg?cgc?atg?cgt?gcc?gta?gac?atc?cta?ttt?gaa 211

Gly?Ser?Arg?Tyr?Lys?Ala?Arg?Met?Arg?Ala?Val?Asp?Ile?Leu?Phe?Glu

25 30 35

gcg?gaa?tcc?cgc?gat?gtt?gat?ccc?gtg?gcc?atc?atc?gat?gac?cgc?cac 259

Ala?Glu?Ser?Arg?Asp?Val?Asp?Pro?Val?Ala?Ile?Ile?Asp?Asp?Arg?His

40 45 50

aag?ttg?gcg?cgc?gat?acc?aac?ccc?atc?gtt?gca?ccg?gta?gcg?gaa?tac 307

Lys?Leu?Ala?Arg?Asp?Thr?Asn?Pro?Ile?Val?Ala?Pro?Val?Ala?Glu?Tyr

55 60 65

acc?gaa?acc?atc?atc?aat?ggc?gtt?gcc?gtt?gaa?ctc?gat?acc?ctc?gat 355

Thr?Glu?Thr?Ile?Ile?Asn?Gly?Val?Ala?Val?Glu?Leu?Asp?Thr?Leu?Asp

70 75 80 85

gtc?ttc?ctc?gcg?gaa?cac?atc?gca?gaa?acc?tgg?act?ctc?gga?cga?ctc 403

Val?Phe?Leu?Ala?Glu?His?Ile?Ala?Glu?Thr?Trp?Thr?Leu?Gly?Arg?Leu

90 95 100

cca?tcc?gtc?gac?cgc?gca?atc?ctg?cgc?gtc?gct?tcc?tgg?gaa?atg?atc 451

Pro?Ser?Val?Asp?Arg?Ala?Ile?Leu?Arg?Val?Ala?Ser?Trp?Glu?Met?Ile

105 110 115

tac?aac?gcc?gac?gtt?cct?gtc?acc?acc?gca?atc?gtt?gaa?gcc?gtg?gaa 499

Tyr?Asn?Ala?Asp?Val?Pro?Val?Thr?Thr?Ala?Ile?Val?Glu?Ala?Val?Glu

120 125 130

att?gcc?tcc?gaa?tac?tcc?gga?gac?aaa?tcc?agt?gcc?tac?atc?aac?gcg 547

Ile?Ala?Ser?Glu?Tyr?Ser?Gly?Asp?Lys?Ser?Ser?Ala?Tyr?Ile?Asn?Ala

135 140 145

aca?ctt?gac?gcc?atg?gca?tca?aag?gtg?gag?acc?ctc?cgc?gag?cgc?gcc 595

Thr?Leu?Asp?Ala?Met?Ala?Ser?Lys?Val?Glu?Thr?Leu?Arg?Glu?Arg?Ala

150 155 160 165

gcc?aac?cca?gaa?gca?gtt?ctg?gcg?gaa?gct?tcc?gaa?tct?ctc?gat?gat 643

Ala?Asn?Pro?Glu?Ala?Val?Leu?Ala?Glu?Ala?Ser?Glu?Ser?Leu?Asp?Asp

170 175 180

gct?ccg?gtc?gcg?ccg?tgg?gat?gac?tcg?gat?gct?ttg?gat?gac?tcg?gat 691

Ala?Pro?Val?Ala?Pro?Trp?Asp?Asp?Ser?Asp?Ala?Leu?Asp?Asp?Ser?Asp

185 190 195

gaa?gat?ttt?gag?gct?gta?gat?gct?gct?gag?gtt?ttt?gag?gct?gaa?gag 739

Glu?Asp?Phe?Glu?Ala?Val?Asp?Ala?Ala?Glu?Val?Phe?Glu?Ala?Glu?Glu

200 205 210

act?gta?gag?gtt?tcc?gaa?gtc?gca?gaa?gac?tct?gaa?gtt?tca?aag?gtt 787

Thr?Val?Glu?Val?Ser?Glu?Val?Ala?Glu?Asp?Ser?Glu?Val?Ser?Lys?Val

215 220 225

tca?gaa?gaa?aag?gct?gac?gag?agc?taaatctttt?ctggctaaca?cca 834

Ser?Glu?Glu?Lys?Ala?Asp?Glu?Ser

230 235

<210>310

<211>237

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>310

Leu?Ile?Glu?Gln?Glu?Gln?Arg?Glu?Gln?Asn?Val?Ser?Glu?Arg?Arg?Gln

1 5 10 15

Asp?Tyr?Lys?Arg?His?Gly?Ser?Arg?Tyr?Lys?Ala?Arg?Met?Arg?Ala?Val

20 25 30

Asp?Ile?Leu?Phe?Glu?Ala?Glu?Ser?Arg?Asp?Val?Asp?Pro?Val?Ala?Ile

35 40 45

Ile?Asp?Asp?Arg?His?Lys?Leu?Ala?Arg?Asp?Thr?Asn?Pro?Ile?Val?Ala

50 55 60

Pro?Val?Ala?Glu?Tyr?Thr?Glu?Thr?Ile?Ile?Asn?Gly?Val?Ala?Val?Glu

65 70 75 80

Leu?Asp?Thr?Leu?Asp?Val?Phe?Leu?Ala?Glu?His?Ile?Ala?Glu?Thr?Trp

85 90 95

Thr?Leu?Gly?Arg?Leu?Pro?Ser?Val?Asp?Arg?Ala?Ile?Leu?Arg?Val?Ala

100 105 110

Ser?Trp?Glu?Met?Ile?Tyr?Asn?Ala?Asp?Val?Pro?Val?Thr?Thr?Ala?Ile

115 120 125

Val?Glu?Ala?Val?Glu?Ile?Ala?Ser?Glu?Tyr?Ser?Gly?Asp?Lys?Ser?Ser

130 135 140

Ala?Tyr?Ile?Asn?Ala?Thr?Leu?Asp?Ala?Met?Ala?Ser?Lys?Val?Glu?Thr

145 150 155 160

Leu?Arg?Glu?Arg?Ala?Ala?Asn?Pro?Glu?Ala?Val?Leu?Ala?Glu?Ala?Ser

165 170 175

Glu?Ser?Leu?Asp?Asp?Ala?Pro?Val?Ala?Pro?Trp?Asp?Asp?Ser?Asp?Ala

180 185 190

Leu?Asp?Asp?Ser?Asp?Glu?Asp?Phe?Glu?Ala?Val?Asp?Ala?Ala?Glu?Val

195 200 205

Phe?Glu?Ala?Glu?Glu?Thr?Val?Glu?Val?Ser?Glu?Val?Ala?Glu?Asp?Ser

210 215 220

Glu?Val?Ser?Lys?Val?Ser?Glu?Glu?Lys?Ala?Asp?Glu?Ser

225 230 235

<210>311

<211>1458

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1435)

<223>RXA01303

<400>311

aaeatgcggg?cgcaggtcag?agctgttatct?tagtactta?tcacagccat?agggcgggct?60

tgacggaaag?cctttccgcg?taaccatgaa?gaggcatcac?gtg?aca?caa?ctc?aac 115

Val?Thr?Gln?Leu?Asn

1 5

acc?aaa?ggc?gtt?gtt?ctg?caa?ggg?tgg?gat?cca?gaa?gat?cct?gaa?cat 163

Thr?Lys?Gly?Val?Val?Leu?Gln?Gly?Trp?Asp?Pro?Glu?Asp?Pro?Glu?His

10 15 20

tgg?gac?tcg?aaa?att?gca?tgg?cga?acc?ctg?tgg?att?acc?acc?ttc?tcc 211

Trp?Asp?Ser?Lys?Ile?Ala?Trp?Arg?Thr?Leu?Trp?Ile?Thr?Thr?Phe?Ser

25 30 35

atg?att?att?ggg?ttc?tgc?gtg?tgg?tat?ttg?gtt?tct?gcc?atc?gct?ccc 259

Met?Ile?Ile?Gly?Phe?Cys?Val?Trp?Tyr?Leu?Val?Ser?Ala?Ile?Ala?Pro

40 45 50

cta?ctc?aat?cga?att?gga?ttt?gat?ctc?tca?gca?ggt?cag?ctt?tat?tgg 307

Leu?Leu?Asn?Arg?Ile?Gly?Phe?Asp?Leu?Ser?Ala?Gly?Gln?Leu?Tyr?Trp

55 60 65

ctc?gca?tct?atc?ccc?ggt?ttg?gcc?ggc?gga?tta?atc?cga?ttg?att?tac 355

Leu?Ala?Ser?Ile?Pro?Gly?Leu?Ala?Gly?Gly?Leu?Ile?Arg?Leu?Ile?Tyr

70 75 80 85

atg?ttc?ctt?cca?ccg?att?ctt?gga?acc?cgc?aaa?ttg?gtc?gga?att?tcc 403

Met?Phe?Leu?Pro?Pro?Ile?Leu?Gly?Thr?Arg?Lys?Leu?Val?Gly?Ile?Ser

90 95 100

tcc?ggt?cta?ttt?ttg?atc?ccc?atg?ttt?ggg?tgg?ttc?ctg?gct?gtc?caa 451

Ser?Gly?Leu?Phe?Leu?Ile?Pro?Met?Phe?Gly?Trp?Phe?Leu?Ala?Val?Gln

105 110 115

gat?tca?agc?act?ccc?tac?tgg?tgg?ctt?ctc?aca?ctc?gct?gca?ctc?act 499

Asp?Ser?Ser?Thr?Pro?Tyr?Trp?Trp?Leu?Leu?Thr?Leu?Ala?Ala?Leu?Thr

120 125 130

ggc?att?ggt?ggt?ggc?gtg?ttc?tct?gga?tat?atg?ccg?tcc?acg?gga?tac 547

Gly?Ile?Gly?Gly?Gly?Val?Phe?Ser?Gly?Tyr?Met?Pro?Ser?Thr?Gly?Tyr

135 140 145

ttc?ttc?ccc?aag?gca?aaa?tcg?ggc?act?gcg?ctg?ggc?att?cag?gca?ggt 595

Phe?Phe?Pro?Lys?Ala?Lys?Ser?Gly?Thr?Ala?Leu?Gly?Ile?Gln?Ala?Gly

150 155 160 165

atc?ggc?aac?ctc?ggc?gtc?tcg?ata?att?cag?ttc?atg?ggc?cca?tgg?gtc 643

Ile?Gly?Asn?Leu?Gly?Val?Ser?Ile?Ile?Gln?Phe?Met?Gly?Pro?Trp?Val

170 175 180

atg?ggt?ttc?ggt?ctg?ctg?ggc?att?ggt?ttc?ctc?acc?ccg?cag?cgc?acc 691

Met?Gly?Phe?Gly?Leu?Leu?Gly?Ile?Gly?Phe?Leu?Thr?Pro?Gln?Arg?Thr

185 190 195

att?gaa?ggc?acc?acg?gtg?ttt?gtg?cac?aat?gct?gcg?att?gtg?ttg?gtc 739

Ile?Glu?Gly?Thr?Thr?Val?Phe?Val?His?Asn?Ala?Ala?Ile?Val?Leu?Val

200 205 210

ccg?tgg?act?att?ctc?gcg?gcc?gtt?tta?tcc?ttc?ctg?ttt?ctt?aaa?gat 787

Pro?Trp?Thr?Ile?Leu?Ala?Ala?Val?Leu?Ser?Phe?Leu?Phe?Leu?Lys?Asp

215 220 225

gtc?cca?gtc?acc?gca?aat?ttc?cgg?caa?cag?atc?gat?atc?ttt?ggc?aac 835

Val?Pro?Val?Thr?Ala?Asn?Phe?Arg?Gln?Gln?Ile?Asp?Ile?Phe?Gly?Asn

230 235 240 245

aag?aac?aca?tgg?att?ttg?tcc?att?atc?tac?ttg?atg?aca?ttc?ggt?gcc 883

Lys?Asn?Thr?Trp?Ile?Leu?Ser?Ile?Ile?Tyr?Leu?Met?Thr?Phe?Gly?Ala

250 255 260

ttc?gcc?ggt?ttc?gcc?gcg?cag?ttc?ggt?ctg?atc?atc?aac?aac?aac?ttc 931

Phe?Ala?Gly?Phe?Ala?Ala?Gln?Phe?Gly?Leu?Ile?Ile?Asn?Asn?Asn?Phe

265 270 275

ggc?atc?gct?tcc?ccg?atg?gca?gag?act?tat?cca?gct?gag?atg?ctt?cac 979

Gly?Ile?Ala?Ser?Pro?Met?Ala?Glu?Thr?Tyr?Pro?Ala?Glu?Met?Leu?His

280 285 290

gcc?ggt?gct?acg?ttc?gcg?ttt?ctt?gga?cct?ttg?att?ggt?gct?ttg?gtg 1027

Ala?Gly?Ala?Thr?Phe?Ala?Phe?Leu?Gly?Pro?Leu?Ile?Gly?Ala?Leu?Val

295 300 305

cgt?gct?gca?tgg?ggt?cca?ctg?tgt?gac?aga?ttc?ggt?gga?gct?atc?tgg 1075

Arg?Ala?Ala?Trp?Gly?Pro?Leu?Cys?Asp?Arg?Phe?Gly?Gly?Ala?Ile?Trp

310 315 320 325

acc?ttt?gtc?ggt?ggc?atc?gga?atg?act?atc?gcc?act?gca?gct?gcc?gca 1123

Thr?Phe?Val?Gly?Gly?Ile?Gly?Met?Thr?Ile?Ala?Thr?Ala?Ala?Ala?Ala

330 335 340

atc?ttc?cta?agc?aga?gcg?gag?aca?cct?gat?gat?ttc?tgg?cca?ttc?ctg 1171

Ile?Phe?Leu?Ser?Arg?Ala?Glu?Thr?Pro?Asp?Asp?Phe?Trp?Pro?Phe?Leu

345 350 355

tgg?tcc?atg?ctt?gcc?ctg?ttc?ttc?ttc?acc?ggt?ctg?ggc?aat?gct?ggc 1219

Trp?Ser?Met?Leu?Ala?Leu?Phe?Phe?Phe?Thr?Gly?Leu?Gly?Asn?Ala?Gly

360 365 370

acc?ttc?aaa?caa?atg?ccc?atg?att?ttg?cct?aaa?cgc?caa?gca?ggt?ggc 1267

Thr?Phe?Lys?Gln?Met?Pro?Met?Ile?Leu?Pro?Lys?Arg?Gln?Ala?Gly?Gly

375 380 385

gtg?atc?ggc?tgg?acc?ggt?gcc?att?ggt?gcc?ttc?ggc?ccc?ttc?att?gtc 1315

Val?Ile?Gly?Trp?Thr?Gly?Ala?Ile?Gly?Ala?Phe?Gly?Pro?Phe?Ile?Val

390 395 400 405

ggt?gtc?ttg?ctc?tcc?ttc?act?cca?act?gtc?gcg?ttc?ttc?tgg?ggc?tgc 1363

Gly?Val?Leu?Leu?Ser?Phe?Thr?Pro?Thr?Val?Ala?Phe?Phe?Trp?Gly?Cys

410 415 420

gtg?gtg?ttc?ttc?atc?atc?gcc?acc?gct?ttg?acc?tgg?atc?tac?tac?gcc 1411

Val?Val?Phe?Phe?Ile?Ile?Ala?Thr?Ala?Leu?Thr?Trp?Ile?Tyr?Tyr?Ala

425 430 435

cgc?ccg?aac?gct?cca?ttc?ccg?gga?taaaccgaaa?ggccaatcca?tga 1458

Arg?Pro?Asn?Ala?Pro?Phe?Pro?Gly

440 445

<210>312

<211>445

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>312

Val?Thr?Gln?Leu?Asn?Thr?Lys?Gly?Val?Val?Leu?Gln?Gly?Trp?Asp?Pro

1 5 10 15

Glu?Asp?Pro?Glu?His?Trp?Asp?Ser?Lys?Ile?Ala?Trp?Arg?Thr?Leu?Trp

20 25 30

Ile?Thr?Thr?Phe?Ser?Met?Ile?Ile?Gly?Phe?Cys?Val?Trp?Tyr?Leu?Val

35 40 45

Ser?Ala?Ile?Ala?Pro?Leu?Leu?Asn?Arg?Ile?Gly?Phe?Asp?Leu?Ser?Ala

50 55 60

Gly?Gln?Leu?Tyr?Trp?Leu?Ala?Ser?Ile?Pro?Gly?Leu?Ala?Gly?Gly?Leu

65 70 75 80

Ile?Arg?Leu?Ile?Tyr?Met?Phe?Leu?Pro?Pro?Ile?Leu?Gly?Thr?Arg?Lys

85 90 95

Leu?Val?Gly?Ile?Ser?Ser?Gly?Leu?Phe?Leu?Ile?Pro?Met?Phe?Gly?Trp

100 105 110

Phe?Leu?Ala?Val?Gln?Asp?Ser?Ser?Thr?Pro?Tyr?Trp?Trp?Leu?Leu?Thr

115 120 125

Leu?Ala?Ala?Leu?Thr?Gly?Ile?Gly?Gly?Gly?Val?Phe?Ser?Gly?Tyr?Met

130 135 140

Pro?Ser?Thr?Gly?Tyr?Phe?Phe?Pro?Lys?Ala?Lys?Ser?Gly?Thr?Ala?Leu

145 150 155 160

Gly?Ile?Gln?Ala?Gly?Ile?Gly?Asn?Leu?Gly?Val?Ser?Ile?Ile?Gln?Phe

165 170 175

Met?Gly?Pro?Trp?Val?Met?Gly?Phe?Gly?Leu?Leu?Gly?Ile?Gly?Phe?Leu

180 185 190

Thr?Pro?Gln?Arg?Thr?Ile?Glu?Gly?Thr?Thr?Val?Phe?Val?His?Asn?Ala

195 200 205

Ala?Ile?Val?Leu?Val?Pro?Trp?Thr?Ile?Leu?Ala?Ala?Val?Leu?Ser?Phe

210 215 220

Leu?Phe?Leu?Lys?Asp?Val?Pro?Val?Thr?Ala?Asn?Phe?Arg?Gln?Gln?Ile

225 230 235 240

Asp?Ile?Phe?Gly?Asn?Lys?Asn?Thr?Trp?Ile?Leu?Ser?Ile?Ile?Tyr?Leu

245 250 255

Met?Thr?Phe?Gly?Ala?Phe?Ala?Gly?Phe?Ala?Ala?Gln?Phe?Gly?Leu?Ile

260 265 270

Ile?Asn?Asn?Asn?Phe?Gly?Ile?Ala?Ser?Pro?Met?Ala?Glu?Thr?Tyr?Pro

275 280 285

Ala?Glu?Met?Leu?His?Ala?Gly?Ala?Thr?Phe?Ala?Phe?Leu?Gly?Pro?Leu

290 295 300

Ile?Gly?Ala?Leu?Val?Arg?Ala?Ala?Trp?Gly?Pro?Leu?Cys?Asp?Arg?Phe

305 310 315 320

Gly?Gly?Ala?Ile?Trp?Thr?Phe?Val?Gly?Gly?Ile?Gly?Met?Thr?Ile?Ala

325 330 335

Thr?Ala?Ala?Ala?Ala?Ile?Phe?Leu?Ser?Arg?Ala?Glu?Thr?Pro?Asp?Asp

340 345 350

Phe?Trp?Pro?Phe?Leu?Trp?Ser?Met?Leu?Ala?Leu?Phe?Phe?Phe?Thr?Gly

355 360 365

Leu?Gly?Asn?Ala?Gly?Thr?Phe?Lys?Gln?Met?Pro?Met?Ile?Leu?Pro?Lys

370 375 380

Arg?Gln?Ala?Gly?Gly?Val?Ile?Gly?Trp?Thr?Gly?Ala?Ile?Gly?Ala?Phe

385 390 395 400

Gly?Pro?Phe?Ile?Val?Gly?Val?Leu?Leu?Ser?Phe?Thr?Pro?Thr?Val?Ala

405 410 415

Phe?Phe?Trp?Gly?Cys?Val?Val?Phe?Phe?Ile?Ile?Ala?Thr?Ala?Leu?Thr

420 425 430

Trp?Ile?Tyr?Tyr?Ala?Arg?Pro?Asn?Ala?Pro?Phe?Pro?Gly

435 440 445

<210>313

<211>327

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(304)

<223>RXA01412

<400>313

cgccttcttt?gcagctgaga?attaactcac?ccttgccctt?ataccccata?ggggtatagc?60

cttgagggag?agagtacttc?acctgaaagg?ggccagtgac?atg?gca?tta?aag?aac 115

Met?Ala?Leu?Lys?Asn

1 5

tac?acc?gtt?gag?ggc?atg?acc?tgc?gca?cac?tgc?gtg?gca?tcg?gta?act 163

Tyr?Thr?Val?Glu?Gly?Met?Thr?Cys?Ala?His?Cys?Val?Ala?Ser?Val?Thr

10 15 20

gaa?gag?gta?agc?gaa?gtt?aat?ggc?gtt?agc?gct?gtt?gac?gtc?act?cta 211

Glu?Glu?Val?Ser?Glu?Val?Asn?Gly?Val?Ser?Ala?Val?Asp?Val?Thr?Leu

25 30 35

gaa?tca?gga?aac?gtc?gct?gtc?agt?ggc?gaa?ggt?ttc?agc?gat?gca?gag 259

Glu?Ser?Gly?Asn?Val?Ala?Val?Ser?Gly?Glu?Gly?Phe?Ser?Asp?Ala?Glu

40 45 50

atc?cag?gct?gct?gta?gag?gaa?gcc?ggc?tac?aag?atc?gtt?gcc?tcc 304

Ile?Gln?Ala?Ala?Val?Glu?Glu?Ala?Gly?Tyr?Lys?Ile?Val?Ala?Ser

55 60 65

taaagcaccc?aagaacattt?aaa 327

<210>314

<211>68

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>314

Met?Ala?Leu?Lys?Asn?Tyr?Thr?Val?Glu?Gly?Met?Thr?Cys?Ala?His?Cys

1 5 10 15

Val?Ala?Ser?Val?Thr?Glu?Glu?Val?Ser?Glu?Val?Asn?Gly?Val?Ser?Ala

20 25 30

Val?Asp?Val?Thr?Leu?Glu?Ser?Gly?Asn?Val?Ala?Val?Ser?Gly?Glu?Gly

35 40 45

Phe?Ser?Asp?Ala?Glu?Ile?Gln?Ala?Ala?Val?Glu?Glu?Ala?Gly?Tyr?Lys

50 55 60

Ile?Val?Ala?Ser

65

<210>315

<211>1266

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1243)

<223>RXA00773

<400>315

gcccccaaaa?agtgaaagca?caccactttc?ctagttgcgc?cctgctcaca?atttgcttca?60

aatattttgc?ccaacctgat?tcacggggga?caatagttag?gtg?act?tta?aaa?atc 115

Val?Thr?Leu?Lys?Ile

1 5

ggc?ccc?ttt?gac?ctt?gcc?tcc?cct?gtg?gtt?cta?gcc?ccc?atg?gct?ggt 163

Gly?Pro?Phe?Asp?Leu?Ala?Ser?Pro?Val?Val?Leu?Ala?Pro?Met?Ala?Gly

10 15 20

gta?acc?aac?gtt?gct?ttc?cgc?acg?ctg?tgc?cgt?gaa?cag?gaa?atg?caa 211

Val?Thr?Asn?Val?Ala?Phe?Arg?Thr?Leu?Cys?Arg?Glu?Gln?Glu?Met?Gln

25 30 35

cgc?acg?gga?aca?atc?tcg?ggg?ctg?tac?gtc?tgt?gaa?atg?gtg?act?gcg 259

Arg?Thr?Gly?Thr?Ile?Ser?Gly?Leu?Tyr?Val?Cys?Glu?Met?Val?Thr?Ala

40 45 50

cgt?gct?ctt?gtt?gag?cgc?aat?gag?aaa?acc?atg?cac?atg?acc?acc?ttc 307

Arg?Ala?Leu?Val?Glu?Arg?Asn?Glu?Lys?Thr?Met?His?Met?Thr?Thr?Phe

55 60 65

gcg?ccg?gat?gaa?aat?ccc?cga?agc?ttg?cag?ctg?tac?acg?gtt?gac?ccg 355

Ala?Pro?Asp?Glu?Asn?Pro?Arg?Ser?Leu?Gln?Leu?Tyr?Thr?Val?Asp?Pro

70 75 80 85

aag?tac?acc?tac?gaa?gcg?gcg?aag?atg?atc?gtt?gat?gaa?aac?ttg?gcg 403

Lys?Tyr?Thr?Tyr?Glu?Ala?Ala?Lys?Met?Ile?Val?Asp?Glu?Asn?Leu?Ala

90 95 100

gat?cat?att?gat?atg?aac?ttt?ggc?tgc?ccg?gtt?cca?aag?gtc?acg?cgc 451

Asp?His?Ile?Asp?Met?Asn?Phe?Gly?Cys?Pro?Val?Pro?Lys?Val?Thr?Arg

105 110 115

cgg?ggt?ggc?ggt?tct?gcg?att?cct?tac?aag?cgc?cgt?ttg?ttt?gaa?aac 499

Arg?Gly?Gly?Gly?Ser?Ala?Ile?Pro?Tyr?Lys?Arg?Arg?Leu?Phe?Glu?Asn

120 125 130

atc?gtt?tcc?gcg?gct?gtg?aag?gct?acg?gaa?ggc?acg?gac?att?ccg?gtg 547

Ile?Val?Ser?Ala?Ala?Val?Lys?Ala?Thr?Glu?Gly?Thr?Asp?Ile?Pro?Val

135 140 145

acg?gtg?aag?ttc?cgc?gtt?ggt?att?gat?gat?gag?cac?cat?act?cac?ttg 595

Thr?Val?Lys?Phe?Arg?Val?Gly?Ile?Asp?Asp?Glu?His?His?Thr?His?Leu

150 155 160 165

gat?gct?gga?cgc?att?gct?gtc?gac?gcc?ggc?gcg?aag?tcc?gta?gcg?ctt 643

Asp?Ala?Gly?Arg?Ile?Ala?Val?Asp?Ala?Gly?Ala?Lys?Ser?Val?Ala?Leu

170 175 180

cac?gcc?cgc?act?gcg?gcg?cag?cgc?tat?tcc?ggt?gag?gct?gat?tgg?aac 691

His?Ala?Arg?Thr?Ala?Ala?Gln?Arg?Tyr?Ser?Gly?Glu?Ala?Asp?Trp?Asn

185 190 195

gag?atc?gcg?cgc?ctg?aag?gag?cat?ttg?gca?gat?acc?ggc?atc?cca?gtt 739

Glu?Ile?Ala?Arg?Leu?Lys?Glu?His?Leu?Ala?Asp?Thr?Gly?Ile?Pro?Val

200 205 210

ttg?ggc?aat?ggc?gat?att?ttc?gcg?gca?tcc?gat?gca?acg?cgc?atg?atg 787

Leu?Gly?Asn?Gly?Asp?Ile?Phe?Ala?Ala?Ser?Asp?Ala?Thr?Arg?Met?Met

215 220 225

gag?caa?act?ggc?tgc?gat?ggc?gtc?gtg?gtt?ggg?cgt?ggt?tgc?ctg?ggc 835

Glu?Gln?Thr?Gly?Cys?Asp?Gly?Val?Val?Val?Gly?Arg?Gly?Cys?Leu?Gly

230 235 240 245

agg?cct?tgg?ctc?ttt?gct?gag?ctg?tct?gct?gct?gtt?cgt?gga?gaa?gaa 883

Arg?Pro?Trp?Leu?Phe?Ala?Glu?Leu?Ser?Ala?Ala?Val?Arg?Gly?Glu?Glu

250 255 260

atc?cca?gag?gag?cct?acc?ttc?ggc?gaa?gtt?acc?caa?atc?atc?ctg?cgc 931

Ile?Pro?Glu?Glu?Pro?Thr?Phe?Gly?Glu?Val?Thr?Gln?Ile?Ile?Leu?Arg

265 270 275

cac?gca?gaa?ctc?ctc?atg?cag?cat?gat?ggc?gaa?acc?aag?ggg?ctg?cgc 979

His?Ala?Glu?Leu?Leu?Met?Gln?His?Asp?Gly?Glu?Thr?Lys?Gly?Leu?Arg

280 285 290

gat?ctg?cgt?aag?cac?atg?ggt?tgg?tac?ctg?cgc?ggt?ttc?cct?gtt?ggc 1027

Asp?Leu?Arg?Lys?His?Met?Gly?Trp?Tyr?Leu?Arg?Gly?Phe?Pro?Val?Gly

295 300 305

ggc?gaa?ttc?cgc?tcc?aat?ctg?gcc?aag?gtt?tcc?acc?tat?gtg?gag?ctt 1075

Gly?Glu?Phe?Arg?Ser?Asn?Leu?Ala?Lys?Val?Ser?Thr?Tyr?Val?Glu?Leu

310 315 320 325

gag?gat?ctc?cta?gca?cca?tgg?gct?gac?tcc?acc?gcc?aag?gca?gag?gac 1123

Glu?Asp?Leu?Leu?Ala?Pro?Trp?Ala?Asp?Ser?Thr?Ala?Lys?Ala?Glu?Asp

330 335 340

gcg?gaa?ggt?gca?cga?ggt?cga?cag?ggc?gct?cct?gca?aag?gtg?gca?ctt 1171

Ala?Glu?Gly?Ala?Arg?Gly?Arg?Gln?Gly?Ala?Pro?Ala?Lys?Val?Ala?Leu

345 350 355

cea?gat?ggc?tgg?ttg?gac?gat?cct?gag?gat?gcc?act?gtt?cct?aaa?ggc 1219

Pro?Asp?Gly?Trp?Leu?Asp?Asp?Pro?Glu?Asp?Ala?Thr?Val?Pro?Lys?Gly

360 365 370

gca?gaa?atg?gaa?aac?tcc?gga?ggg?tagttaattt?aatacttacc?ccc 1266

Ala?Glu?Met?Glu?Asn?Ser?Gly?Gly

375 380

<210>316

<211>381

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>316

Val?Thr?Leu?Lys?Ile?Gly?Pro?Phe?Asp?Leu?Ala?Ser?Pro?Val?Val?Leu

1 5 10 15

Ala?Pro?Met?Ala?Gly?Val?Thr?Asn?Val?Ala?Phe?Arg?Thr?Leu?Cys?Arg

20 25 30

Glu?Gln?Glu?Met?Gln?Arg?Thr?Gly?Thr?Ile?Ser?Gly?Leu?Tyr?Val?Cys

35 40 45

Glu?Met?Val?Thr?Ala?Arg?Ala?Leu?Val?Glu?Arg?Asn?Glu?Lys?Thr?Met

50 55 60

His?Met?Thr?Thr?Phe?Ala?Pro?Asp?Glu?Asn?Pro?Arg?Ser?Leu?Gln?Leu

65 70 75 80

Tyr?Thr?Val?Asp?Pro?Lys?Tyr?Thr?Tyr?Glu?Ala?Ala?Lys?Met?Ile?Val

85 90 95

Asp?Glu?Asn?Leu?Ala?Asp?His?Ile?Asp?Met?Asn?Phe?Gly?Cys?Pro?Val

100 105 110

Pro?Lys?Val?Thr?Arg?Arg?Gly?Gly?Gly?Ser?Ala?Ile?Pro?Tyr?Lys?Arg

115 120 125

Arg?Leu?Phe?Glu?Asn?Ile?Val?Ser?Ala?Ala?Val?Lys?Ala?Thr?Glu?Gly

130 135 140

Thr?Asp?Ile?Pro?Val?Thr?Val?Lys?Phe?Arg?Val?Gly?Ile?Asp?Asp?Glu

145 150 155 160

His?His?Thr?His?Leu?Asp?Ala?Gly?Arg?Ile?Ala?Val?Asp?Ala?Gly?Ala

165 170 175

Lys?Ser?Val?Ala?Leu?His?Ala?Arg?Thr?Ala?Ala?Gln?Arg?Tyr?Ser?Gly

180 185 190

Glu?Ala?Asp?Trp?Asn?Glu?Ile?Ala?Arg?Leu?Lys?Glu?His?Leu?Ala?Asp

195 200 205

Thr?Gly?Ile?Pro?Val?Leu?Gly?Asn?Gly?Asp?Ile?Phe?Ala?Ala?Ser?Asp

210 215 220

Ala?Thr?Arg?Met?Met?Glu?Gln?Thr?Gly?Cys?Asp?Gly?Val?Val?Val?Gly

225 230 235 240

Arg?Gly?Cys?Leu?Gly?Arg?Pro?Trp?Leu?Phe?Ala?Glu?Leu?Ser?Ala?Ala

245 250 255

Val?Arg?Gly?Glu?Glu?Ile?Pro?Glu?Glu?Pro?Thr?Phe?Gly?Glu?Val?Thr

260 265 270

Gln?Ile?Ile?Leu?Arg?His?Ala?Glu?Leu?Leu?Met?Gln?His?Asp?Gly?Glu

275 280 285

Thr?Lys?Gly?Leu?Arg?Asp?Leu?Arg?Lys?His?Met?Gly?Trp?Tyr?Leu?Arg

290 295 300

Gly?Phe?Pro?Val?Gly?Gly?Glu?Phe?Arg?Ser?Asn?Leu?Ala?Lys?Val?Ser

305 310 315 320

Thr?Tyr?Val?Glu?Leu?Glu?Asp?Leu?Leu?Ala?Pro?Trp?Ala?Asp?Ser?Thr

325 330 335

Ala?Lys?Ala?Glu?Asp?Ala?Glu?Gly?Ala?Arg?Gly?Arg?Gln?Gly?Ala?Pro

340 345 350

Ala?Lys?Val?Ala?Leu?Pro?Asp?Gly?Trp?Leu?Asp?Asp?Pro?Glu?Asp?Ala

355 360 365

Thr?Val?Pro?Lys?Gly?Ala?Glu?Met?Glu?Asn?Ser?Gly?Gly

370 375 380

<210>317

<211>290

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(267)

<223>RXA02746

<400>317

ggt?gtg?cag?ggc?atg?act?gtc?acc?gaa?acc?caa?ggc?ttt?ggc?cag?cag 48

Gly?Val?Gln?Gly?Met?Thr?Val?Thr?Glu?Thr?Gln?Gly?Phe?Gly?Gln?Gln

1 5 10 15

aaa?ggc?cac?acc?gag?gtg?tac?cgt?ggt?gct?gaa?tac?gct?gtc?gat?ttt 96

Lys?Gly?His?Thr?Glu?Val?Tyr?Arg?Gly?Ala?Glu?Tyr?Ala?Val?Asp?Phe

20 25 30

gtg?cct?aag?gtc?aag?att?gaa?gtt?att?atc?tcc?gat?gct?cag?gct?gag 144

Val?Pro?Lys?Val?Lys?Ile?Glu?Val?Ile?Ile?Ser?Asp?Ala?Gln?Ala?Glu

35 40 45

gaa?gtc?atc?aac?att?atc?gtc?gag?acc?gca?cgc?acc?ggc?aaa?gtc?ggc 192

Glu?Val?Ile?Asn?Ile?Ile?Val?Glu?Thr?Ala?Arg?Thr?Gly?Lys?Val?Gly

50 55 60

gac?ggc?aaa?gtg?tgg?atg?act?aac?atc?gaa?gag?ctg?gtt?cgt?gtt?cgt 240

Asp?Gly?Lys?Val?Trp?Met?Thr?Asn?Ile?Glu?Glu?Leu?Val?Arg?Val?Arg

65 70 75 80

acc?ggt?gag?cgc?ggc?gaa?gca?gcc?ctt?taaaaactta?tgaataatcc 287

Thr?Gly?Glu?Arg?Gly?Glu?Ala?Ala?Leu

85

agc 290

<210>318

<211>89

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>318

Gly?Val?Gln?Gly?Met?Thr?Val?Thr?Glu?Thr?Gln?Gly?Phe?Gly?Gln?Gln

1 5 10 15

Lys?Gly?His?Thr?Glu?Val?Tyr?Arg?Gly?Ala?Glu?Tyr?Ala?Val?Asp?Phe

20 25 30

Val?Pro?Lys?Val?Lys?Ile?Glu?Val?Ile?Ile?Ser?Asp?Ala?Gln?Ala?Glu

35 40 45

Glu?Val?Ile?Asn?Ile?Ile?Val?Glu?Thr?Ala?Arg?Thr?Gly?Lys?Val?Gly

50 55 60

Asp?Gly?Lys?Val?Trp?Met?Thr?Asn?Ile?Glu?Glu?Leu?Val?Arg?Val?Arg

65 70 75 80

Thr?Gly?Glu?Arg?Gly?Glu?Ala?Ala?Leu

85

<210>319

<211>902

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(879)

<223>RXA02745

<400>319

gcc?gga?atc?tcc?ttc?gaa?gtc?ccc?cgc?ggt?caa?gtt?ttg?gcc?ctc?ctg 48

Ala?Gly?Ile?Ser?Phe?Glu?Val?Pro?Arg?Gly?Gln?Val?Leu?Ala?Leu?Leu

1 5 10 15

gga?cct?aat?ggc?gca?ggc?aaa?acc?acc?acc?att?gaa?atg?tgc?gaa?ggt 96

Gly?Pro?Asn?Gly?Ala?Gly?Lys?Thr?Thr?Thr?Ile?Glu?Met?Cys?Glu?Gly

20 25 30

ttt?acc?gcc?ccc?acc?tct?ggc?agc?atc?cga?gtc?ttg?ggc?atc?gat?cca 144

Phe?Thr?Ala?Pro?Thr?Ser?Gly?Ser?Ile?Arg?Val?Leu?Gly?Ile?Asp?Pro

35 40 45

gcc?aca?gaa?cca?gac?cag?gtg?cgc?cga?cgc?atc?ggc?atc?atg?ctt?caa 192

Ala?Thr?Glu?Pro?Asp?Gln?Val?Arg?Arg?Arg?Ile?Gly?Ile?Met?Leu?Gln

50 55 60

ggt?ggc?ggt?tcc?tac?agc?gga?atc?cgc?gtg?ttt?gaa?atg?ctc?aag?ctt 240

Gly?Gly?Gly?Ser?Tyr?Ser?Gly?Ile?Arg?Val?Phe?Glu?Met?Leu?Lys?Leu

65 70 75 80

gcg?gcg?tcc?tac?aac?gac?aac?cca?cac?gat?cct?gaa?tgg?ctg?ctt?gat 288

Ala?Ala?Ser?Tyr?Asn?Asp?Asn?Pro?His?Asp?Pro?Glu?Trp?Leu?Leu?Asp

85 90 95

ctt?gta?gga?ctg?cgt?gaa?caa?cgc?aaa?acc?acc?tac?cga?cgt?ctg?tca 336

Leu?Val?Gly?Leu?Arg?Glu?Gln?Arg?Lys?Thr?Thr?Tyr?Arg?Arg?Leu?Ser

100 105 110

ggt?ggc?caa?cag?caa?cgc?ctt?tct?ttg?gcc?tta?gca?tta?att?ggt?cgc 384

Gly?Gly?Gln?Gln?Gln?Arg?Leu?Ser?Leu?Ala?Leu?Ala?Leu?Ile?Gly?Arg

115 120 125

cct?gag?att?atc?ttc?ctc?gac?gaa?ccc?acc?gct?ggc?atg?gat?gcg?caa 432

Pro?Glu?Ile?Ile?Phe?Leu?Asp?Glu?Pro?Thr?Ala?Gly?Met?Asp?Ala?Gln

130 135 140

tca?cgc?aac?atg?gtg?tgg?gag?ctt?gtc?aac?gat?ctc?cgc?cgc?gac?ggc 480

Ser?Arg?Asn?Met?Val?Trp?Glu?Leu?Val?Asn?Asp?Leu?Arg?Arg?Asp?Gly

145 150 155 160

gtc?acc?atc?gtg?ctc?acc?acc?cac?ctg?atg?gat?gag?gcc?gaa?gca?cta 528

Val?Thr?Ile?Val?Leu?Thr?Thr?His?Leu?Met?Asp?Glu?Ala?Glu?Ala?Leu

165 170 175

gct?gac?cac?gtg?atc?atc?gtt?gcc?aac?ggt?caa?atc?ctt?gcc?agt?ggc 576

Ala?Asp?His?Val?Ile?Ile?Val?Ala?Asn?Gly?Gln?Ile?Leu?Ala?Ser?Gly

180 185 190

aca?cct?gat?gaa?ctc?act?gcg?caa?cgc?gat?cat?ctt?gaa?att?aat?gtc 624

Thr?Pro?Asp?Glu?Leu?Thr?Ala?Gln?Arg?Asp?His?Leu?Glu?Ile?Asn?Val

195 200 205

tcc?gta?gag?acc?acg?agc?ccg?ctt?gat?ctt?gat?cgc?ttg?gtg?gat?gat 672

Ser?Val?Glu?Thr?Thr?Ser?Pro?Leu?Asp?Leu?Asp?Arg?Leu?Val?Asp?Asp

210 215 220

ctc?agc?agc?tta?aac?atc?ggt?gat?gtg?aaa?gca?cga?gcc?aac?cgg?cca 720

Leu?Ser?Ser?Leu?Asn?Ile?Gly?Asp?Val?Lys?Ala?Arg?Ala?Asn?Arg?Pro

225 230 235 240

ctg?cat?tat?tca?ctt?cgg?acg?caa?caa?gcc?acc?ccg?gat?tcc?ttg?gcg 768

Leu?His?Tyr?Ser?Leu?Arg?Thr?Gln?Gln?Ala?Thr?Pro?Asp?Ser?Leu?Ala

245 250 255

cac?atc?gtc?cag?gct?gtc?gcc?cgc?caa?aac?gtc?atg?att?cgc?tct?ttg 816

His?Ile?Val?Gln?Ala?Val?Ala?Arg?Gln?Asn?Val?Met?Ile?Arg?Ser?Leu

260 265 270

gat?acg?gga?cac?cgc?tca?ttg?gaa?gat?gtc?ttc?ctg?gac?atc?acc?gga 864

Asp?Thr?Gly?His?Arg?Ser?Leu?Glu?Asp?Val?Phe?Leu?Asp?Ile?Thr?Gly

275 280 285

aaa?gaa?ctg?agg?agt?taacgcacac?catgtctaaa?cct 902

Lys?Glu?Leu?Arg?Ser

290

<210>320

<211>293

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>320

Ala?Gly?Ile?Ser?Phe?Glu?Val?Pro?Arg?Gly?Gln?Val?Leu?Ala?Leu?Leu

1 5 10 15

Gly?Pro?Asn?Gly?Ala?Gly?Lys?Thr?Thr?Thr?Ile?Glu?Met?Cys?Glu?Gly

20 25 30

Phe?Thr?Ala?Pro?Thr?Ser?Gly?Ser?Ile?Arg?Val?Leu?Gly?Ile?Asp?Pro

35 40 45

Ala?Thr?Glu?Pro?Asp?Gln?Val?Arg?Arg?Arg?Ile?Gly?Ile?Met?Leu?Gln

50 55 60

Gly?Gly?Gly?Ser?Tyr?Ser?Gly?Ile?Arg?Val?Phe?Glu?Met?Leu?Lys?Leu

65 70 75 80

Ala?Ala?Ser?Tyr?Asn?Asp?Asn?Pro?His?Asp?Pro?Glu?Trp?Leu?Leu?Asp

85 90 95

Leu?Val?Gly?Leu?Arg?Glu?Gln?Arg?Lys?Thr?Thr?Tyr?Arg?Arg?Leu?Ser

100 105 110

Gly?Gly?Gln?Gln?Gln?Arg?Leu?Ser?Leu?Ala?Leu?Ala?Leu?Ile?Gly?Arg

115 120 125

Pro?Glu?Ile?Ile?Phe?Leu?Asp?Glu?Pro?Thr?Ala?Gly?Met?Asp?Ala?Gln

130 135 140

Ser?Arg?Asn?Met?Val?Trp?Glu?Leu?Val?Asn?Asp?Leu?Arg?Arg?Asp?Gly

145 150 155 160

Val?Thr?Ile?Val?Leu?Thr?Thr?His?Leu?Met?Asp?Glu?Ala?Glu?Ala?Leu

165 170 175

Ala?Asp?His?Val?Ile?Ile?Val?Ala?Asn?Gly?Gln?Ile?Leu?Ala?Ser?Gly

180 185 190

Thr?Pro?Asp?Glu?Leu?Thr?Ala?Gln?Arg?Asp?His?Leu?Glu?Ile?Asn?Val

195 200 205

Ser?Val?Glu?Thr?Thr?Ser?Pro?Leu?Asp?Leu?Asp?Arg?Leu?Val?Asp?Asp

210 215 220

Leu?Ser?Ser?Leu?Asn?Ile?Gly?Asp?Val?Lys?Ala?Arg?Ala?Asn?Arg?Pro

225 230 235 240

Leu?His?Tyr?Ser?Leu?Arg?Thr?Gln?Gln?Ala?Thr?Pro?Asp?Ser?Leu?Ala

245 250 255

His?Ile?Val?Gln?Ala?Val?Ala?Arg?Gln?Asn?Val?Met?Ile?Arg?Ser?Leu

260 265 270

Asp?Thr?Gly?His?Arg?Ser?Leu?Glu?Asp?Val?Phe?Leu?Asp?Ile?Thr?Gly

275 280 285

Lys?Glu?Leu?Arg?Ser

290

<210>321

<211>486

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(463)

<223>RXN00820

<400>321

acttccacca?ccccaaacca?tcgtttcttt?cgaagacgca?ccaaccctca?ccggccagga?60

cctgggcttt?tcgcagtggc?gcactgtcac?ccaggagatg?gtg?aac?acc?ttg?gcg 115

Val?Asn?Thr?Leu?Ala

1 5

gac?gca?act?gat?gat?cag?cag?tgg?att?cac?act?gat?cct?gag?cgc?gcc 163

Asp?Ala?Thr?Asp?Asp?Gln?Gln?Trp?Ile?His?Thr?Asp?Pro?Glu?Arg?Ala

10 15 20

aag?gac?ggt?cct?ttt?ggt?ggc?gca?att?gcc?cac?ggt?ttc?ctc?acc?ttg 211

Lys?Asp?Gly?Pro?Phe?Gly?Gly?Ala?Ile?Ala?His?Gly?Phe?Leu?Thr?Leu

25 30 35

tcc?atg?atc?att?ccg?ttc?tgg?ggc?gag?ctt?ctc?gat?gtc?acc?ggc?gtg 259

Ser?Met?Ile?Ile?Pro?Phe?Trp?Gly?Glu?Leu?Leu?Asp?Val?Thr?Gly?Val

40 45 50

acc?acc?aag?gtg?aac?tat?ggc?ctg?gat?aag?gtg?cgt?ttc?acc?tct?ccc 307

Thr?Thr?Lys?Val?Asn?Tyr?Gly?Leu?Asp?Lys?Val?Arg?Phe?Thr?Ser?Pro

55 60 65

gtc?aag?gtc?ggt?tcc?cgc?arc?cgc?atg?ggc?gct?gtg?gtc?cgt?gag?atc 355

Val?Lys?Val?Gly?Ser?Arg?Ile?Arg?Met?Gly?Ala?Val?Val?Arg?Glu?Ile

70 75 80 85

tct?gag?gtg?aag?ggc?aat?ggc?ctg?cac?ctg?gtc?gcc?gat?ggc?act?att 403

Ser?Glu?Val?Lys?Gly?Asn?Gly?Leu?His?Leu?Val?Ala?Asp?Gly?Thr?Ile

90 95 100

gag?atc?gaa?ggg?cag?gag?cgc?ccg?gcc?gtc?gta?gct?acc?ttc?ctc?acc 451

Glu?Ile?Glu?Gly?Gln?Glu?Arg?Pro?Ala?Val?Val?Ala?Thr?Phe?Leu?Thr

105 110 115

cgc?ttc?tac?gct?taaaagcttg?cttctcgacg?caa 486

Arg?Phe?Tyr?Ala

120

<210>322

<211>121

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>322

Val?Asn?Thr?Leu?Ala?Asp?Ala?Thr?Asp?Asp?Gln?Gln?Trp?Ile?His?Thr

1 5 10 15

Asp?Pro?Glu?Arg?Ala?Lys?Asp?Gly?Pro?Phe?Gly?Gly?Ala?Ile?Ala?His

20 25 30

Gly?Phe?Leu?Thr?Leu?Ser?Met?Ile?Ile?Pro?Phe?Trp?Gly?Glu?Leu?Leu

35 40 45

Asp?Val?Thr?Gly?Val?Thr?Thr?Lys?Val?Asn?Tyr?Gly?Leu?Asp?Lys?Val

50 55 60

Arg?Phe?Thr?Ser?Pro?Val?Lys?Val?Gly?Ser?Arg?Ile?Arg?Met?Gly?Ala

65 70 75 80

Val?Val?Arg?Glu?Ile?Ser?Glu?Val?Lys?Gly?Asn?Gly?Leu?His?Leu?Val

85 90 95

Ala?Asp?Gly?Thr?Ile?Glu?Ile?Glu?Gly?Gln?Glu?Arg?Pro?Ala?Val?Val

100 105 110

Ala?Thr?Phe?Leu?Thr?Arg?Phe?Tyr?Ala

115 120

<210>323

<211>486

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(463)

<223>FRXA00820

<400>323

acttccacca?ccccaaacca?tcgtttcttt?cgaagacgca?ccaaccctca?ccggccagga?60

cctgggcttt?tcgcagtggc?gcactgtcac?ccaggagatg?gtg?aac?acc?ttc?gcg 115

Val?Asn?Thr?Phe?Ala

1 5

gac?gca?act?gat?gat?cag?cag?tgg?att?cac?act?gat?cct?gag?cgc?gcc 163

Asp?Ala?Thr?Asp?Asp?Gln?Gln?Trp?Ile?His?Thr?Asp?Pro?Glu?Arg?Ala

10 15 20

aag?gac?ggt?cct?ttt?ggt?ggc?gca?att?gcc?cac?ggt?ttc?ctc?acc?ttg 211

Lys?Asp?Gly?Pro?Phe?Gly?Gly?Ala?Ile?Ala?His?Gly?Phe?Leu?Thr?Leu

25 30 35

tcc?atg?atc?att?ccg?ttc?tgg?ggc?gag?ctt?ctc?gat?gtc?acc?ggc?gtg 259

Ser?Met?Ile?Ile?Pro?Phe?Trp?Gly?Glu?Leu?Leu?Asp?Val?Thr?Gly?Val

40 45 50

acc?acc?aag?gtg?aac?tat?ggc?ctg?gat?aag?gtg?cgt?ttc?acc?tct?ccc 307

Thr?Thr?Lys?Val?Asn?Tyr?Gly?Leu?Asp?Lys?Val?Arg?Phe?Thr?Ser?Pro

55 60 65

gtc?aag?gtc?ggt?tcc?cgc?atc?cgc?atg?ggc?gct?gtg?gtc?cgt?gag?atc 355

Val?Lys?Val?Gly?Ser?Arg?Ile?Arg?Met?Gly?Ala?Val?Val?Arg?Glu?Ile

70 75 80 85

tct?gag?gtg?aag?ggc?aat?ggc?ctg?cac?ctg?gtc?gcc?gat?ggc?act?att 403

Ser?Glu?Val?Lys?Gly?Asn?Gly?Leu?His?Leu?Val?Ala?Asp?Gly?Thr?Ile

90 95 100

gag?atc?gaa?ggg?cag?gag?cgc?ccg?gcc?gtc?gta?gct?acc?ttc?ctc?acc 451

Glu?Ile?Glu?Gly?Gln?Glu?Arg?Pro?Ala?Val?Val?Ala?Thr?Phe?Leu?Thr

105 110 115

cgc?ttc?tac?gct?taaaagcttg?cttctcgacg?caa 486

Arg?Phe?Tyr?Ala

120

<210>324

<211>121

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>324

Val?Asn?Thr?Phe?Ala?Asp?Ala?Thr?Asp?Asp?Gln?Gln?Trp?Ile?His?Thr

1 5 10 15

Asp?Pro?Glu?Arg?Ala?Lys?Asp?Gly?Pro?Phe?Gly?Gly?Ala?Ile?Ala?His

20 25 30

Gly?Phe?Leu?Thr?Leu?Ser?Met?Ile?Ile?Pro?Phe?Trp?Gly?Glu?Leu?Leu

35 40 45

Asp?Val?Thr?Gly?Val?Thr?Thr?Lys?Val?Asn?Tyr?Gly?Leu?Asp?Lys?Val

50 55 60

Arg?Phe?Thr?Ser?Pro?Val?Lys?Val?Gly?Ser?Arg?Ile?Arg?Met?Gly?Ala

65 70 75 80

Val?Val?Arg?Glu?Ile?Ser?Glu?Val?Lys?Gly?Asn?Gly?Leu?His?Leu?Val

85 90 95

Ala?Asp?Gly?Thr?Ile?Glu?Ile?Glu?Gly?Gln?Glu?Arg?Pro?Ala?Val?Val

100 105 110

Ala?Thr?Phe?Leu?Thr?Arg?Phe?Tyr?Ala

115 120

<210>325

<211>732

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(709)

<223>RXA01059

<400>325

aattattagc?tttccaatac?aaaatttaaa?tcccagagcg?atctgcccca?cacttacttg?60

atgcgggaac?aaatttgaag?gtttttcagt?tgctataggt?atg?act?aca?gtt?act 115

Met?Thr?Thr?Val?Thr

1 5

caa?gac?ctt?cta?gca?ctt?gac?gaa?gac?gca?cag?aac?ctc?ctt?ttc?cgt 163

Gln?Asp?Leu?Leu?Ala?Leu?Asp?Glu?Asp?Ala?Gln?Asn?Leu?Leu?Phe?Arg

10 15 20

gag?gct?cgc?acc?gca?aat?gct?ttc?act?gat?gaa?cca?atc?tct?gac?gag 211

Glu?Ala?Arg?Thr?Ala?Asn?Ala?Phe?Thr?Asp?Glu?Pro?Ile?Ser?Asp?Glu

25 30 35

cag?atc?gaa?gca?atc?ttc?gac?cta?gtt?aag?tgg?gca?cca?acc?gca?atg 259

Gln?Ile?Glu?Ala?Ile?Phe?Asp?Leu?Val?Lys?Trp?Ala?Pro?Thr?Ala?Met

40 45 50

aac?tcc?cag?cct?ctg?cgc?gtg?gta?att?gtt?cgt?tcc?gaa?gaa?gcc?aaa 307

Asn?Ser?Gln?Pro?Leu?Arg?Val?Val?Ile?Val?Arg?Ser?Glu?Glu?Ala?Lys

55 60 65

gct?cgc?ctc?gtg?cca?ttg?atg?gca?gaa?ggc?aac?cag?gcc?aag?gtt?gct 355

Ala?Arg?Leu?Val?Pro?Leu?Met?Ala?Glu?Gly?Asn?Gln?Ala?Lys?Val?Ala

70 75 80 85

gca?gct?cct?gcg?gtc?gca?ctt?ctt?gca?gcc?gac?atc?gac?ttc?cac?gaa 403

Ala?Ala?Pro?Ala?Val?Ala?Leu?Leu?Ala?Ala?Asp?Ile?Asp?Phe?His?Glu

90 95 100

gaa?atg?ccc?aag?ctc?ttc?cca?cct?ttc?cca?ggc?gca?cgc?gac?atg?ttc 451

Glu?Met?Pro?Lys?Leu?Phe?Pro?Pro?Phe?Pro?Gly?Ala?Arg?Asp?Met?Phe

105 110 115

gaa?gcc?gat?gaa?gct?tca?cgt?gct?tcc?tcc?gca?gaa?ctc?aat?gct?ggc 499

Glu?Ala?Asp?Glu?Ala?Ser?Arg?Ala?Ser?Ser?Ala?Glu?Leu?Asn?Ala?Gly

120 125 130

ctt?cag?atc?gga?tac?gcc?atc?atc?ggt?atc?cgc?gca?gca?ggt?ctc?gcc 547

Leu?Gln?Ile?Gly?Tyr?Ala?Ile?Ile?Gly?Ile?Arg?Ala?Ala?Gly?Leu?Ala

135 140 145

gct?ggc?cca?atg?acc?ggc?atg?gat?gca?gac?gct?atc?tcc?aag?gag?ttc 595

Ala?Gly?Pro?Met?Thr?Gly?Met?Asp?Ala?Asp?Ala?Ile?Ser?Lys?Glu?Phe

150 155 160 165

ttc?cca?gac?ggc?cgc?cac?cgc?gtt?ctg?gtt?gcc?atc?aac?atg?ggt?aag 643

Phe?Pro?Asp?Gly?Arg?His?Arg?Val?Leu?Val?Ala?Ile?Asn?Met?Gly?Lys

170 175 180

cca?gct?gac?aat?gct?tgg?tac?gac?cgc?ctg?cca?cgc?ctt?gag?cag?gac 691

Pro?Ala?Asp?Asn?Ala?Trp?Tyr?Asp?Arg?Leu?Pro?Arg?Leu?Glu?Gln?Asp

185 190 195

gaa?gtt?gtc?gaa?acc?ctc?tagaaaccac?tctagaaata?gct 732

Glu?Val?Val?Glu?Thr?Leu

200

<210>326

<211>203

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>326

Met?Thr?Thr?Val?Thr?Gln?Asp?Leu?Leu?Ala?Leu?Asp?Glu?Asp?Ala?Gln

1 5 10 15

Asn?Leu?Leu?Phe?Arg?Glu?Ala?Arg?Thr?Ala?Asn?Ala?Phe?Thr?Asp?Glu

20 25 30

Pro?Ile?Ser?Asp?Glu?Gln?Ile?Glu?Ala?Ile?Phe?Asp?Leu?Val?Lys?Trp

35 40 45

Ala?Pro?Thr?Ala?Met?Asn?Ser?Gln?Pro?Leu?Arg?Val?Val?Ile?Val?Arg

50 55 60

Ser?Glu?Glu?Ala?Lys?Ala?Arg?Leu?Val?Pro?Leu?Met?Ala?Glu?Gly?Asn

65 70 75 80

Gln?Ala?Lys?Val?Ala?Ala?Ala?Pro?Ala?Val?Ala?Leu?Leu?Ala?Ala?Asp

85 90 95

Ile?Asp?Phe?His?Glu?Glu?Met?Pro?Lys?Leu?Phe?Pro?Pro?Phe?Pro?Gly

100 105 110

Ala?Arg?Asp?Met?Phe?Glu?Ala?Asp?Glu?Ala?Ser?Arg?Ala?Ser?Ser?Ala

115 120 125

Glu?Leu?Asn?Ala?Gly?Leu?Gln?Ile?Gly?Tyr?Ala?Ile?Ile?Gly?Ile?Arg

130 135 140

Ala?Ala?Gly?Leu?Ala?Ala?Gly?Pro?Met?Thr?Gly?Met?Asp?Ala?Asp?Ala

145 150 155 160

Ile?Ser?Lys?Glu?Phe?Phe?Pro?Asp?Gly?Arg?His?Arg?Val?Leu?Val?Ala

165 170 175

Ile?Asn?Met?Gly?Lys?Pro?Ala?Asp?Asn?Ala?Trp?Tyr?Asp?Arg?Leu?Pro

180 185 190

Arg?Leu?Glu?Gln?Asp?Glu?Val?Val?Glu?Thr?Leu

195 200

<210>327

<211>1053

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1030)

<223>RXN01386

<400>327

ctctattgtg?gtacgcacca?tgactgctca?accagcccac?gagccgccaa?ggcatctccg?60

gttcagtacg?agcgggatcc?tcccggacaa?tcgcgtccaa?atg?tgg?gag?ggc?cac 115

Met?Trp?Glu?Gly?His

1 5

aat?gct?cgc?gca?ttg?ctt?ccg?ctc?gac?att?aga?acc?att?gac?gat?cgc 163

Asn?Ala?Arg?Ala?Leu?Leu?Pro?Leu?Asp?Ile?Arg?Thr?Ile?Asp?Asp?Arg

10 15 20

ccc?atg?cag?gcc?tcc?gaa?acc?aac?ctg?cac?ctc?cca?tca?atg?cgg?atg 211

Pro?Met?Gln?Ala?Ser?Glu?Thr?Asn?Leu?His?Leu?Pro?Ser?Met?Arg?Met

25 30 35

gcg?agc?gta?ttc?ggg?act?tcg?caa?ttt?gtc?gag?cgt?tca?gag?agt?ttc 259

Ala?Ser?Val?Phe?Gly?Thr?Ser?Gln?Phe?Val?Glu?Arg?Ser?Glu?Ser?Phe

40 45 50

atc?tca?gaa?aac?ccc?acg?ggt?gtg?gtt?gcg?atc?ttc?ttt?gcg?act?gaa 307

Ile?Ser?Glu?Asn?Pro?Thr?Gly?Val?Val?Ala?Ile?Phe?Phe?Ala?Thr?Glu

55 60 65

ggt?gaa?gca?gtc?ttc?ttc?cac?cgt?ggt?gga?cat?gta?gcg?ctt?cgg?cca 355

Gly?Glu?Ala?Val?Phe?Phe?His?Arg?Gly?Gly?His?Val?Ala?Leu?Arg?Pro

70 75 80 85

ggt?cag?gcc?att?gtt?tac?gac?gcc?gat?agg?cca?ttc?ctc?cgc?gga?ttc 403

Gly?Gln?Ala?Ile?Val?Tyr?Asp?Ala?Asp?Arg?Pro?Phe?Leu?Arg?Gly?Phe

90 95 100

aac?aat?cgc?ttc?cgc?gag?cta?gtt?ctc?acc?atc?ccg?aag?cag?cgc?tac 451

Asn?Asn?Arg?Phe?Arg?Glu?Leu?Val?Leu?Thr?Ile?Pro?Lys?Gln?Arg?Tyr

105 110 115

ctt?gaa?att?gtt?ggc?tca?aaa?ggc?cct?gag?ctt?ccc?gct?att?ttt?gag 499

Leu?Glu?Ile?Val?Gly?Ser?Lys?Gly?Pro?Glu?Leu?Pro?Ala?Ile?Phe?Glu

120 125 130

ttc?gga?gca?aca?gga?acc?gcc?aat?gaa?caa?gct?tta?gcg?cga?cta?gtt 547

Phe?Gly?Ala?Thr?Gly?Thr?Ala?Asn?Glu?Gln?Ala?Leu?Ala?Arg?Leu?Val

135 140 145

cag?gaa?tct?cta?cac?agg?att?gaa?agt?ggc?gag?ccg?aag?cat?atc?gat 595

Gln?Glu?Ser?Leu?His?Arg?Ile?Glu?Ser?Gly?Glu?Pro?Lys?His?Ile?Asp

150 155 160 165

tcc?agt?gga?cct?tta?gga?aaa?ccg?tgg?agc?gat?atc?gag?cac?gag?gcc 643

Ser?Ser?Gly?Pro?Leu?Gly?Lys?Pro?Trp?Ser?Asp?Ile?Glu?His?Glu?Ala

170 175 180

cac?gga?ctt?atc?cgc?aat?gta?ctt?ggc?gac?gcc?aca?agt?agc?gaa?gaa 691

His?Gly?Leu?Ile?Arg?Asn?Val?Leu?Gly?Asp?Ala?Thr?Ser?Ser?Glu?Glu

185 190 195

ggc?tta?att?tct?gca?gcc?cag?aga?ttt?att?gac?atc?aat?att?tcc?gaa 739

Gly?Leu?Ile?Ser?Ala?Ala?Gln?Arg?Phe?Ile?Asp?Ile?Asn?Ile?Ser?Glu

200 205 210

agt?gac?tta?caa?gcg?tcg?cgg?att?gct?gca?gcc?gtg?gga?atc?agc?gaa 787

Ser?Asp?Leu?Gln?Ala?Ser?Arg?Ile?Ala?Ala?Ala?Val?Gly?Ile?Ser?Glu

215 220 225

cgc?caa?cta?agt?cga?atc?ttc?tca?gac?tca?gga?caa?act?atc?gga?cgc 835

Arg?Gln?Leu?Ser?Arg?Ile?Phe?Ser?Asp?Ser?Gly?Gln?Thr?Ile?Gly?Arg

230 235 240 245

tac?gtc?cta?aac?acc?cga?ctg?gat?ttt?gca?aag?gaa?gcg?ctg?tcg?aca 883

Tyr?Val?Leu?Asn?Thr?Arg?Leu?Asp?Phe?Ala?Lys?Glu?Ala?Leu?Ser?Thr

250 255 260

ccg?gag?cga?gac?aag?gtt?tcg?gtc?agt?gag?atc?ggt?aag?cgc?ttt?ggg 931

Pro?Glu?Arg?Asp?Lys?Val?Ser?Val?Ser?Glu?Ile?Gly?Lys?Arg?Phe?Gly

265 270 275

ttc?gct?tcc?cca?agt?cat?ttc?agt?cgc?acc?ttc?cgc?gag?cgg?ttt?gaa 979

Phe?Ala?Ser?Pro?Ser?His?Phe?Ser?Arg?Thr?Phe?Arg?Glu?Arg?Phe?Glu

280 285 290

atg?acg?ccg?ctt?caa?tgg?agg?aag?gaa?tcg?cag?cgt?caa?tcc?ttt?caa 1027

Met?Thr?Pro?Leu?Gln?Trp?Arg?Lys?Glu?Ser?Gln?Arg?Gln?Ser?Phe?Gln

295 300 305

gag?tgaggttttt?gttctcaggc?gga 1053

Glu

310

<210>328

<211>310

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>328

Met?Trp?Glu?Gly?His?Asn?Ala?Arg?Ala?Leu?Leu?Pro?Leu?Asp?Ile?Arg

1 5 10 15

Thr?Ile?Asp?Asp?Arg?Pro?Met?Gln?Ala?Ser?Glu?Thr?Asn?Leu?His?Leu

20 25 30

Pro?Ser?Met?Arg?Met?Ala?Ser?Val?Phe?Gly?Thr?Ser?Gln?Phe?Val?Glu

35 40 45

Arg?Ser?Glu?Ser?Phe?Ile?Ser?Glu?Asn?Pro?Thr?Gly?Val?Val?Ala?Ile

50 55 60

Phe?Phe?Ala?Thr?Glu?Gly?Glu?Ala?Val?Phe?Phe?His?Arg?Gly?Gly?His

65 70 75 80

Val?Ala?Leu?Arg?Pro?Gly?Gln?Ala?Ile?Val?Tyr?Asp?Ala?Asp?Arg?Pro

85 90 95

Phe?Leu?Arg?Gly?Phe?Asn?Asn?Arg?Phe?Arg?Glu?Leu?Val?Leu?Thr?Ile

100 105 110

Pro?Lys?Gln?Arg?Tyr?Leu?Glu?Ile?Val?Gly?Ser?Lys?Gly?Pro?Glu?Leu

115 120 125

Pro?Ala?Ile?Phe?Glu?Phe?Gly?Ala?Thr?Gly?Thr?Ala?Asn?Glu?Gln?Ala

130 135 140

Leu?Ala?Arg?Leu?Val?Gln?Glu?Ser?Leu?His?Arg?Ile?Glu?Ser?Gly?Glu

145 150 155 160

Pro?Lys?His?Ile?Asp?Ser?Ser?Gly?Pro?Leu?Gly?Lys?Pro?Trp?Ser?Asp

165 170 175

Ile?Glu?His?Glu?Ala?His?Gly?Leu?Ile?Arg?Asn?Val?Leu?Gly?Asp?Ala

180 185 190

Thr?Ser?Ser?Glu?Glu?Gly?Leu?Ile?Ser?Ala?Ala?Gln?Arg?Phe?Ile?Asp

195 200 205

Ile?Asn?Ile?Ser?Glu?Ser?Asp?Leu?Gln?Ala?Ser?Arg?Ile?Ala?Ala?Ala

210 215 220

Val?Gly?Ile?Ser?Glu?Arg?Gln?Leu?Ser?Arg?Ile?Phe?Ser?Asp?Ser?Gly

225 230 235 240

Gln?Thr?Ile?Gly?Arg?Tyr?Val?Leu?Asn?Thr?Arg?Leu?Asp?Phe?Ala?Lys

245 250 255

Glu?Ala?Leu?Ser?Thr?Pro?Glu?Arg?Asp?Lys?Val?Ser?Val?Ser?Glu?Ile

260 265 270

Gly?Lys?Arg?Phe?Gly?Phe?Ala?Ser?Pro?Ser?His?Phe?Ser?Arg?Thr?Phe

275 280 285

Arg?Glu?Arg?Phe?Glu?Met?Thr?Pro?Leu?Gln?Trp?Arg?Lys?Glu?Ser?Gln

290 295 300

Arg?Gln?Ser?Phe?Gln?Glu

305 310

<210>329

<211>1806

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1783)

<223>RXN00073

<400>329

gaatctaatg?gttggtctag?acagagcggt?acgtctaagt?ttgcggatag?atcaaaccga?60

gtgacatgta?cttcactagc?tctttaagga?ttaactcccc?atg?aca?aca?acc?acc 115

Met?Thr?Thr?Thr?Thr

1 5

gga?agt?gcc?cgg?cca?gca?cgt?gcc?gcc?agg?aag?cct?aag?ccc?gaa?ggc 163

Gly?Ser?Ala?Arg?Pro?Ala?Arg?Ala?Ala?Arg?Lys?Pro?Lys?Pro?Glu?Gly

10 15 20

caa?tgg?aaa?atc?gac?ggc?acc?gag?ccg?ctt?aac?cat?gcc?gag?gaa?att 211

Gln?Trp?Lys?Ile?Asp?Gly?Thr?Glu?Pro?Leu?Asn?His?Ala?Glu?Glu?Ile

25 30 35

aag?caa?gaa?gaa?ccc?gct?ttt?gct?gtc?aag?cag?cgg?gtc?att?gat?att 259

Lys?Gln?Glu?Glu?Pro?Ala?Phe?Ala?Val?Lys?Gln?Arg?Val?Ile?Asp?Ile

40 45 50

tac?tcc?aag?cag?ggt?ttt?tct?tcc?att?gca?ccg?gat?gac?att?gcc?cca 307

Tyr?Ser?Lys?Gln?Gly?Phe?Ser?Ser?Ile?Ala?Pro?Asp?Asp?Ile?Ala?Pro

55 60 65

cgc?ttt?aag?tgg?ttg?ggc?att?tac?acc?cag?cgt?aag?cag?gat?ctg?ggc 355

Arg?Phe?Lys?Trp?Leu?Gly?Ile?Tyr?Thr?Gln?Arg?Lys?Gln?Asp?Leu?Gly

70 75 80 85

ggt?gaa?ctg?acc?ggt?cag?ctt?cct?gat?gat?gag?ctg?cag?gat?gag?tac 403

Gly?Glu?Leu?Thr?Gly?Gln?Leu?Pro?Asp?Asp?Glu?Leu?Gln?Asp?Glu?Tyr

90 95 100

ttc?atg?atg?cgt?gtg?cgt?ttt?gat?ggc?gga?ctg?gct?tcc?cct?gag?cgc 451

Phe?Met?Met?Arg?Val?Arg?Phe?Asp?Gly?Gly?Leu?Ala?Ser?Pro?Glu?Arg

105 110 115

ctg?cgt?gcc?gtg?ggt?gaa?att?tct?agg?gat?tat?gct?cgt?tcc?acc?gcg 499

Leu?Arg?Ala?Val?Gly?Glu?Ile?Ser?Arg?Asp?Tyr?Ala?Arg?Ser?Thr?Ala

120 125 130

gac?ttc?acc?gac?cgc?cag?aac?att?cag?ctg?cac?tgg?att?cgt?att?gaa 547

Asp?Phe?Thr?Asp?Arg?Gln?Asn?Ile?Gln?Leu?His?Trp?Ile?Arg?Ile?Glu

135 140 145

gat?gtg?cct?gcg?atc?tgg?gag?aag?cta?gaa?acc?gtc?gga?ctg?tcc?acc 595

Asp?Val?Pro?Ala?Ile?Trp?Glu?Lys?Leu?Glu?Thr?Val?Gly?Leu?Ser?Thr

150 155 160 165

atg?ctt?ggt?tgc?ggt?gac?gtt?cca?cgt?gtt?atc?ttg?ggc?tcc?cca?gtt 643

Met?Leu?Gly?Cys?Gly?Asp?Val?Pro?Arg?Val?Ile?Leu?Gly?Ser?Pro?Val

170 175 180

tct?ggc?gta?gct?gct?gaa?gag?ctg?atc?gat?gcc?acc?ccg?gct?atc?gat 691

Ser?Gly?Val?Ala?Ala?Glu?Glu?Leu?Ile?Asp?Ala?Thr?Pro?Ala?Ile?Asp

185 190 195

gcg?att?cgt?gag?cgc?tac?cta?gac?aag?gaa?gag?ttc?cac?aac?ctt?cct 739

Ala?Ile?Arg?Glu?Arg?Tyr?Leu?Asp?Lys?Glu?Glu?Phe?His?Asn?Leu?Pro

200 205 210

cgt?aag?ttt?aag?act?gct?atc?act?ggc?aac?cag?cgc?cag?gat?gtt?acc 787

Arg?Lys?Phe?Lys?Thr?Ala?Ile?Thr?Gly?Asn?Gln?Arg?Gln?Asp?Val?Thr

215 220 225

cac?gaa?atc?cag?gac?gtt?tcc?ttc?gtt?cct?tcg?att?cac?cca?gaa?ttc 835

His?Glu?Ile?Gln?Asp?Val?Ser?Phe?Val?Pro?Ser?Ile?His?Pro?Glu?Phe

230 235 240 245

ggc?cca?gga?ttt?gag?tgc?ttt?gtg?ggc?ggt?ggc?ctg?tcc?acc?aac?cca 883

Gly?Pro?Gly?Phe?Glu?Cys?Phe?Val?Gly?Gly?Gly?Leu?Ser?Thr?Asn?Pro

250 255 260

atg?ctt?gct?cag?cca?ctt?ggt?tct?tgg?att?cca?ctt?gat?gag?gtt?cca 931

Met?Leu?Ala?Gln?Pro?Leu?Gly?Ser?Trp?Ile?Pro?Leu?Asp?Glu?Val?Pro

265 270 275

gaa?gtg?tgg?gct?ggc?gtc?gcc?gga?att?ttc?cgc?gac?tac?ggc?ttc?cga 979

Glu?Val?Trp?Ala?Gly?Val?Ala?Gly?Ile?Phe?Arg?Asp?Tyr?Gly?Phe?Arg

280 285 290

cgc?ctg?cgt?aac?cgt?gct?cgc?ctc?aag?ttc?ttg?gtg?gca?cag?tgg?ggt 1027

Arg?Leu?Arg?Asn?Arg?Ala?Arg?Leu?Lys?Phe?Leu?Val?Ala?Gln?Trp?Gly

295 300 305

att?gag?aag?ttc?cgt?gaa?gtt?ctt?gag?acc?gaa?tac?ctc?gag?cgc?aag 1075

Ile?Glu?Lys?Phe?Arg?Glu?Val?Leu?Glu?Thr?Glu?Tyr?Leu?Glu?Arg?Lys

310 315 320 325

ctg?atc?gat?ggc?cca?gtt?gtt?acc?acc?aac?cct?ggc?tac?cgt?gac?cac 1123

Leu?Ile?Asp?Gly?Pro?Val?Val?Thr?Thr?Asn?Pro?Gly?Tyr?Arg?Asp?His

330 335 340

att?ggc?att?cac?cca?caa?aag?gac?ggc?aag?ttc?tac?ctc?ggt?gtg?aag 1171

Ile?Gly?Ile?His?Pro?Gln?Lys?Asp?Gly?Lys?Phe?Tyr?Leu?Gly?Val?Lys

345 350 355

cca?acc?gtt?gga?cac?acc?acc?ggt?gag?cag?ctc?att?gcc?att?gct?gat 1219

Pro?Thr?Val?Gly?His?Thr?Thr?Gly?Glu?Gln?Leu?Ile?Ala?Ile?Ala?Asp

360 365 370

gtt?gca?gaa?aag?cac?ggc?atc?acc?agg?att?cgt?acc?acg?gcg?gaa?aag 1267

Val?Ala?Glu?Lys?His?Gly?Ile?Thr?Arg?Ile?Arg?Thr?Thr?Ala?Glu?Lys

375 380 385

gaa?ctg?ctc?ttc?ctc?gat?att?gag?aga?aag?aac?ctt?act?acc?gtt?gca 1315

Glu?Leu?Leu?Phe?Leu?Asp?Ile?Glu?Arg?Lys?Asn?Leu?Thr?Thr?Val?Ala

390 395 400 405

cgc?gac?ctg?gat?gaa?atc?gga?ctg?tac?tct?tca?cct?tcc?gag?ttc?cgc 1363

Arg?Asp?Leu?Asp?Glu?Ile?Gly?Leu?Tyr?Ser?Ser?Pro?Ser?Glu?Phe?Arg

410 415 420

cgc?ggc?atc?att?tcc?tgc?acc?ggc?ttg?gag?ttc?tgc?aag?ctt?gcg?cac 1411

Arg?Gly?Ile?Ile?Ser?Cys?Thr?Gly?Leu?Glu?Phe?Cys?Lys?Leu?Ala?His

425 430 435

gca?acc?acc?aag?tca?cga?gca?att?gag?ctt?gtc?gac?gaa?ctg?gaa?gag 1459

Ala?Thr?Thr?Lys?Ser?Arg?Ala?Ile?Glu?Leu?Val?Asp?Glu?Leu?Glu?Glu

440 445 450

cgc?ctc?ggc?gat?ttg?gat?gtt?ccc?atc?aag?att?gca?ctg?aac?ggt?tgc 1507

Arg?Leu?Gly?Asp?Leu?Asp?Val?Pro?Ile?Lys?Ile?Ala?Leu?Asn?Gly?Cys

455 460 465

cct?aac?tct?tgt?gca?cgc?acc?cag?gtt?tcc?gac?atc?gga?ttc?aag?gga 1555

Pro?Asn?Ser?Cys?Ala?Arg?Thr?Gln?Val?Ser?Asp?Ile?Gly?Phe?Lys?Gly

470 475 480 485

cag?acc?gtc?act?gat?gct?gac?ggc?aac?cgc?gtt?gaa?ggt?ttc?cag?gtt 1603

Gln?Thr?Val?Thr?Asp?Ala?Asp?Gly?Asn?Arg?Val?Glu?Gly?Phe?Gln?Val

490 495 500

cac?ctg?ggc?ggt?tcc?atg?aac?ttg?gat?cca?aac?ttc?gga?cgc?aag?ctc 1651

His?Leu?Gly?Gly?Ser?Met?Asn?Leu?Asp?Pro?Asn?Phe?Gly?Arg?Lys?Leu

505 510 515

aag?ggc?cac?aag?gtt?att?gcc?gat?gaa?gtg?gga?gag?tac?gtc?act?cgc 1699

Lys?Gly?His?Lys?Val?Ile?Ala?Asp?Glu?Val?Gly?Glu?Tyr?Val?Thr?Arg

520 525 530

gtt?gtt?acc?cac?ttc?aag?gaa?cag?cgc?cac?gag?gac?gag?cacttc?cgc 1747

Val?Val?Thr?His?Phe?Lys?Glu?Gln?Arg?His?Glu?Asp?Glu?His?Phe?Arg

535 540 545

gat?tgg?gtc?cag?cgg?gcc?gct?gag?gaa?gat?ttg?gtg?tgagtcttcg 1793

Asp?Trp?Val?Gln?Arg?Ala?Ala?Glu?Glu?Asp?Leu?Val

550 555 560

gaggaaaccc?aat 1806

<210>330

<211>56l

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>330

Met?Thr?Thr?Thr?Thr?Gly?Ser?Ala?Arg?Pro?Ala?Arg?Ala?Ala?Arg?Lys

1 5 10 15

Pro?Lys?Pro?Glu?Gly?Gln?Trp?Lys?Ile?Asp?Gly?Thr?Glu?Pro?Leu?Asn

20 25 30

His?Ala?Glu?Glu?Ile?Lys?Gln?Glu?Glu?Pro?Ala?Phe?Ala?Val?Lys?Gln

35 40 45

Arg?Val?Ile?Asp?Ile?Tyr?Ser?Lys?Gln?Gly?Phe?Ser?Ser?Ile?Ala?Pro

50 55 60

Asp?Asp?Ile?Ala?Pro?Arg?Phe?Lys?Trp?Leu?Gly?Ile?Tyr?Thr?Gln?Arg

65 70 75 80

Lys?Gln?Asp?Leu?Gly?Gly?Glu?Leu?Thr?Gly?Gln?Leu?Pro?Asp?Asp?Glu

85 90 95

Leu?Gln?Asp?Glu?Tyr?Phe?Met?Met?Arg?Val?Arg?Phe?Asp?Gly?Gly?Leu

100 105 110

Ala?Ser?Pro?Glu?Arg?Leu?Arg?Ala?Val?Gly?Glu?Ile?Ser?Arg?Asp?Tyr

115 120 125

Ala?Arg?Ser?Thr?Ala?Asp?Phe?Thr?Asp?Arg?Gln?Asn?Ile?Gln?Leu?His

130 135 140

Trp?Ile?Arg?Ile?Glu?Asp?Val?Pro?Ala?Ile?Trp?Glu?Lys?Leu?Glu?Thr

145 150 155 160

Val?Gly?Leu?Ser?Thr?Met?Leu?Gly?Cys?Gly?Asp?Val?Pro?Arg?Val?Ile

165 170 175

Leu?Gly?Ser?Pro?Val?Ser?Gly?Val?Ala?Ala?Glu?Glu?Leu?Ile?Asp?Ala

180 185 190

Thr?Pro?Ala?Ile?Asp?Ala?Ile?Arg?Glu?Arg?Tyr?Leu?Asp?Lys?Glu?Glu

195 200 205

Phe?His?Asn?Leu?Pro?Arg?Lys?Phe?Lys?Thr?Ala?Ile?Thr?Gly?Asn?Gln

210 215 220

Arg?Gln?Asp?Val?Thr?His?Glu?Ile?Gln?Asp?Val?Ser?Phe?Val?Pro?Ser

225 230 235 240

Ile?His?Pro?Glu?Phe?Gly?Pro?Gly?Phe?Glu?Cys?Phe?Val?Gly?Gly?Gly

245 250 255

Leu?Ser?Thr?Asn?Pro?Met?Leu?Ala?Gln?Pro?Leu?Gly?Ser?Trp?Ile?Pro

260 265 270

Leu?Asp?Glu?Val?Pro?Glu?Val?Trp?Ala?Gly?Val?Ala?Gly?Ile?Phe?Arg

275 280 285

Asp?Tyr?Gly?Phe?Arg?Arg?Leu?Arg?Asn?Arg?Ala?Arg?Leu?Lys?Phe?Leu

290 295 300

Val?Ala?Gln?Trp?Gly?Ile?Glu?Lys?Phe?Arg?Glu?Val?Leu?Glu?Thr?Glu

305 310 315 320

Tyr?Leu?Glu?Arg?Lys?Leu?Ile?Asp?Gly?Pro?Val?Val?Thr?Thr?Asn?Pro

325 330 335

Gly?Tyr?Arg?Asp?His?Ile?Gly?Ile?His?Pro?Gln?Lys?Asp?Gly?Lys?Phe

340 345 350

Tyr?Leu?Gly?Val?Lys?Pro?Thr?Val?Gly?His?Thr?Thr?Gly?Glu?Gln?Leu

355 360 365

Ile?Ala?Ile?Ala?Asp?Val?Ala?Glu?Lys?His?Gly?Ile?Thr?Arg?Ile?Arg

370 375 380

Thr?Thr?Ala?Glu?Lys?Glu?Leu?Leu?Phe?Leu?Asp?Ile?Glu?Arg?Lys?Asn

385 390 395 400

Leu?Thr?Thr?Val?Ala?Arg?Asp?Leu?Asp?Glu?Ile?Gly?Leu?Tyr?Ser?Ser

405 410 415

Pro?Ser?Glu?Phe?Arg?Arg?Gly?Ile?Ile?Ser?Cys?Thr?Gly?Leu?Glu?Phe

420 425 430

Cys?Lys?Leu?Ala?His?Ala?Thr?Thr?Lys?Ser?Arg?Ala?Ile?Glu?Leu?Val

435 440 445

Asp?Glu?Leu?Glu?Glu?Arg?Leu?Gly?Asp?Leu?Asp?Val?Pro?Ile?Lys?Ile

450 455 460

Ala?Leu?Asn?Gly?Cys?Pro?Asn?Ser?Cys?Ala?Arg?Thr?Gln?Val?Ser?Asp

465 470 475 480

Ile?Gly?Phe?Lys?Gly?Gln?Thr?Val?Thr?Asp?Ala?Asp?Gly?Asn?Arg?Val

485 490 495

Glu?Gly?Phe?Gln?Val?His?Leu?Gly?Gly?Ser?Met?Asn?Leu?Asp?Pro?Asn

500 505 510

Phe?Gly?Arg?Lys?Leu?Lys?Gly?His?Lys?Val?Ile?Ala?Asp?Glu?Val?Gly

515 520 525

Glu?Tyr?Val?Thr?Arg?Val?Val?Thr?His?Phe?Lys?Glu?Gln?Arg?His?Glu

530 535 540

Asp?Glu?His?Phe?Arg?Asp?Trp?Val?Gln?Arg?Ala?Ala?Glu?Glu?Asp?Leu

545 550 555 560

Val

<210>331

<211>373

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(373)

<223>RXN03131

<400>331

aacgcggctc?gtgaagatta?cctgaaaaac?caagccctcc?agcgtccgct?gctcggctaa?60

accagttggc?taaaccaaaa?cgtatttaag?gagaaacacc?atg?acc?act?tct?gta 115

Met?Thr?Thr?Ser?Val

1 5

cct?gca?tcc?acc?aaa?gct?tta?tct?gtg?gct?ggc?gaa?aac?cca?ggc?ctg 163

Pro?Ala?Ser?Thr?Lys?Ala?Leu?Ser?Val?Ala?Gly?Glu?Asn?Pro?Gly?Leu

10 15 20

cgc?atc?ggc?acc?gca?cct?gac?tcg?tgg?ggc?gtg?tgg?ttc?cca?gag?gat 211

Arg?Ile?Gly?Thr?Ala?Pro?Asp?Ser?Trp?Gly?Val?Trp?Phe?Pro?Glu?Asp

25 30 35

cca?aag?cag?atc?cct?tgg?gag?cgt?ttt?ctc?tac?gag?gtc?gtg?aaa?gct 259

Pro?Lys?Gln?Ile?Pro?Trp?Glu?Arg?Phe?Leu?Tyr?Glu?Val?Val?Lys?Ala

40 45 50

ggc?tac?acc?tgg?atc?gag?ctt?ggc?cca?tac?ggc?tac?ctg?cca?acc?gat 307

Gly?Tyr?Thr?Trp?Ile?Glu?Leu?Gly?Pro?Tyr?Gly?Tyr?Leu?Pro?Thr?Asp

55 60 65

gcc?aac?cag?ctt?gaa?gat?gaa?ctg?ggc?aag?cgc?ggc?ctg?aag?ctg?tcc 355

Ala?Asn?Gln?Leu?Glu?Asp?Glu?Leu?Gly?Lys?Arg?Gly?Leu?Lys?Leu?Ser

70 75 80 85

gct?ggc?acc?gag?ttc?acc 373

Ala?Gly?Thr?Glu?Phe?Thr

90

<210>332

<211>91

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>332

Met?Thr?Thr?Ser?Val?Pro?Ala?Ser?Thr?Lys?Ala?Leu?Ser?Val?Ala?Gly

1 5 10 15

Glu?Asn?Pro?Gly?Leu?Arg?Ile?Gly?Thr?Ala?Pro?Asp?Ser?Trp?Gly?Val

20 25 30

Trp?Phe?Pro?Glu?Asp?Pro?Lys?Gln?Ile?Pro?Trp?Glu?Arg?Phe?Leu?Tyr

35 40 45

Glu?Val?Val?Lys?Ala?Gly?Tyr?Thr?Trp?Ile?Glu?Leu?Gly?Pro?Tyr?Gly

50 55 60

Tyr?Leu?Pro?Thr?Asp?Ala?Asn?Gln?Leu?Glu?Asp?Glu?Leu?Gly?Lys?Arg

65 70 75 80

Gly?Leu?Lys?Leu?Ser?Ala?Gly?Thr?Glu?Phe?Thr

85 90

<210>333

<211>549

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(526)

<223>RXS00153

<400>333

cctcgatttg?agtaaagagg?acgtcctcgc?ctgatttttc?gggtgtgttt?ttgcgtggcg?60

agccctgcct?ggcccttcca?aattatgtag?ggtggcctgc?gtg?gga?gca?ata?att 115

Val?Gly?Ala?Ile?Ile

1 5

tgg?ttt?atc?gga?gca?ttg?gtt?ctt?gct?ggc?ttg?gaa?ttg?gca?gta?ggt 163

Trp?Phe?Ile?Gly?Ala?Leu?Val?Leu?Ala?Gly?Leu?Glu?Leu?Ala?Val?Gly

10 15 20

gag?ttc?acc?tta?ttg?atg?ctc?ggc?ggt?gca?gct?ttg?gca?acc?gcc?ggc 211

Glu?Phe?Thr?Leu?Leu?Met?Leu?Gly?Gly?Ala?Ala?Leu?Ala?Thr?Ala?Gly

25 30 35

gtg?gca?ctc?atc?ggt?gtc?cca?gta?tgg?gct?gaa?ttt?gtc?acc?ttc?gcg 259

Val?Ala?Leu?Ile?Gly?Val?Pro?Val?Trp?Ala?Glu?Phe?Val?Thr?Phe?Ala

40 45 50

gtg?gcc?tca?gct?gct?cta?ctg?atg?ttc?att?agg?ccg?gcc?att?aga?aag 307

Val?Ala?Ser?Ala?Ala?Leu?Leu?Met?Phe?Ile?Arg?Pro?Ala?Ile?Arg?Lys

55 60 65

cgt?ctg?ctg?aaa?cca?aag?gtt?ctg?gac?tct?tca?cca?cga?gca?ctt?gtt 355

Arg?Leu?Leu?Lys?Pro?Lys?Val?Leu?Asp?Ser?Ser?Pro?Arg?Ala?Leu?Val

70 75 80 85

ggc?cac?cgt?gct?gaa?gtg?ctc?gaa?gat?gtc?gga?gcg?acc?agc?ggg?cag 403

Gly?His?Arg?Ala?Glu?Val?Leu?Glu?Asp?Val?Gly?Ala?Thr?Ser?Gly?Gln

90 95 100

gtc?cgc?ctg?gat?ggt?tca?att?tgg?tcc?gcc?cgc?agc?atg?gat?ccc?aca 451

Val?Arg?Leu?Asp?Gly?Ser?Ile?Trp?Ser?Ala?Arg?Ser?Met?Asp?Pro?Thr

105 110 115

cac?acc?ttc?gcg?gaa?ggt?gaa?att?gtc?agt?gtc?att?gat?atc?caa?ggc 499

His?Thr?Phe?Ala?Glu?Gly?Glu?Ile?Val?Ser?Val?Ile?Asp?Ile?Gln?Gly

120 125 130

acg?acc?gcg?att?gta?tgg?aaa?gaa?gcc?taaattttta?acaatcaaat 546

Thr?Thr?Ala?Ile?Val?Trp?Lys?Glu?Ala

135 140

agt 549

<210>334

<211>142

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>334

Val?Gly?Ala?Ile?Ile?Trp?Phe?Ile?Gly?Ala?Leu?Val?Leu?Ala?Gly?Leu

1 5 10 15

Glu?Leu?Ala?Val?Gly?Glu?Phe?Thr?Leu?Leu?Met?Leu?Gly?Gly?Ala?Ala

20 25 30

Leu?Ala?Thr?Ala?Gly?Val?Ala?Leu?Ile?Gly?Val?Pro?Val?Trp?Ala?Glu

35 40 45

Phe?Val?Thr?Phe?Ala?Val?Ala?Ser?Ala?Ala?Leu?Leu?Met?Phe?Ile?Arg

50 55 60

Pro?Ala?Ile?Arg?Lys?Arg?Leu?Leu?Lys?Pro?Lys?Val?Leu?Asp?Ser?Ser

65 70 75 80

Pro?Arg?Ala?Leu?Val?Gly?His?Arg?Ala?Glu?Val?Leu?Glu?Asp?Val?Gly

85 90 95

Ala?Thr?Ser?Gly?Gln?Val?Arg?Leu?Asp?Gly?Ser?Ile?Trp?Ser?Ala?Arg

100 105 110

Ser?Met?Asp?Pro?Thr?His?Thr?Phe?Ala?Glu?Gly?Glu?Ile?Val?Ser?Val

115 120 125

Ile?Asp?Ile?Gln?Gly?Thr?Thr?Ala?Ile?Val?Trp?Lys?Glu?Ala

130 135 140

<210>335

<211>509

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(486)

<223>RXN01716

<400>335

gaa?gtc?act?cct?gag?gga?ttc?aaa?gag?atc?acc?cgt?gaa?aac?acc?atc 48

Glu?Val?Thr?Pro?Glu?Gly?Phe?Lys?Glu?Ile?Thr?Arg?Glu?Asn?Thr?Ile

1 5 10 15

gtt?cgc?ctg?ggc?aaa?ggc?gtc?gac?gcc?acc?ggt?cag?cta?gac?ccc?gag 96

Val?Arg?Leu?Gly?Lys?Gly?Val?Asp?Ala?Thr?Gly?Gln?Leu?Asp?Pro?Glu

20 25 30

gca?atc?gag?cgc?act?cgt?gtc?gct?ttg?gaa?aac?tac?gtt?gaa?ctc?atg 144

Ala?Ile?Glu?Arg?Thr?Arg?Val?Ala?Leu?Glu?Asn?Tyr?Val?Glu?Leu?Met

35 40 45

gaa?acc?cat?ggg?gta?gag?gcc?gta?cga?atg?gtt?gcc?acc?tcc?gca?acc 192

Glu?Thr?His?Gly?Val?Glu?Ala?Val?Arg?Met?Val?Ala?Thr?Ser?Ala?Thr

50 55 60

cgc?gat?gcg?tcc?aac?cgc?gat?gaa?ttc?ttt?tcg?atg?acc?cgc?cag?ctt 240

Arg?Asp?Ala?Ser?Asn?Arg?Asp?Glu?Phe?Phe?Ser?Met?Thr?Arg?Gln?Leu

65 70 75 80

ctg?tcc?aag?atc?cgt?cct?gga?tac?caa?gct?gaa?gta?att?tcc?ggc?gaa 288

Leu?Ser?Lys?Ile?Arg?Pro?Gly?Tyr?Gln?Ala?Glu?Val?Ile?Ser?Gly?Glu

85 90 95

gag?gaa?gct?ctg?ctg?tcc?ttc?cga?ggt?gca?atc?gtt?gac?ctg?cct?gaa 336

Glu?Glu?Ala?Leu?Leu?Ser?Phe?Arg?Gly?Ala?Ile?Val?Asp?Leu?Pro?Glu

100 105 110

gac?caa?ggt?cct?ttc?tgt?gtt?atc?gac?ctt?ggc?ggt?gga?tcc?act?gag 384

Asp?Gln?Gly?Pro?Phe?Cys?Val?Ile?Asp?Leu?Gly?Gly?Gly?Ser?Thr?Glu

115 120 125

ttc?atc?gtt?ggc?acc?tac?gac?ggt?gaa?atc?cta?ggc?tcc?cac?tca?acc 432

Phe?Ile?Val?Gly?Thr?Tyr?Asp?Gly?Glu?Ile?Leu?Gly?Ser?His?Ser?Thr

130 135 140

caa?atg?gga?tgc?gtg?cgc?ctg?acc?gaa?cga?atc?atg?cgc?agc?gac?cca 480

Gln?Met?Gly?Cys?Val?Arg?Leu?Thr?Glu?Arg?Ile?Met?Arg?Ser?Asp?Pro

145 150 155 160

ccc?gac?tgaaaccgaa?gtggaaatcg?ccc 509

Pro?Asp

<210>336

<211>162

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>336

Glu?Val?Thr?Pro?Glu?Gly?Phe?Lys?Glu?Ile?Thr?Arg?Glu?Asn?Thr?Ile

1 5 10 15

Val?Arg?Leu?Gly?Lys?Gly?Val?Asp?Ala?Thr?Gly?Gln?Leu?Asp?Pro?Glu

20 25 30

Ala?Ile?Glu?Arg?Thr?Arg?Val?Ala?Leu?Glu?Asn?Tyr?Val?Glu?Leu?Met

35 40 45

Glu?Thr?His?Gly?Val?Glu?Ala?Val?Arg?Met?Val?Ala?Thr?Ser?Ala?Thr

50 55 60

Arg?Asp?Ala?Ser?Asn?Arg?Asp?Glu?Phe?Phe?Ser?Met?Thr?Arg?Gln?Leu

65 70 75 80

Leu?Ser?Lys?Ile?Arg?Pro?Gly?Tyr?Gln?Ala?Glu?Val?Ile?Ser?Gly?Glu

85 90 95

Glu?Glu?Ala?Leu?Leu?Ser?Phe?Arg?Gly?Ala?Ile?Val?Asp?Leu?Pro?Glu

100 105 110

Asp?Gln?Gly?Pro?Phe?Cys?Val?Ile?Asp?Leu?Gly?Gly?Gly?Ser?Thr?Glu

115 120 125

Phe?Ile?Val?Gly?Thr?Tyr?Asp?Gly?Glu?Ile?Leu?Gly?Ser?His?Ser?Thr

130 135 140

Gln?Met?Gly?Cys?Val?Arg?Leu?Thr?Glu?Arg?Ile?Met?Arg?Ser?Asp?Pro

145 150 155 160

Pro?Asp

<210>337

<211>534

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(511)

<223>RXN02972

<400>337

acctacgacg?gtgaaatcct?aggctcccac?tcaacccaaa?tgggatgcgt?gcgcctgacc?60

gaacgaatca?tgcgcagcga?cccacccgac?tgaaaccgaa?gtg?gaa?atc?gcc?cgc 115

Val?Glu?Ile?Ala?Arg

1 5

gac?tac?gtt?gca?gaa?cgc?atc?cag?gaa?gta?aaa?gcc?atc?gtc?cca?att 163

Asp?Tyr?Val?Ala?Glu?Arg?Ile?Gln?Glu?Val?Lys?Ala?Ile?Val?Pro?Ile

10 15 20

tca?aag?gca?aaa?acc?ttt?gtg?gga?tgc?gca?ggc?acc?ttc?acc?aca?atc 211

Ser?Lys?Ala?Lys?Thr?Phe?Val?Gly?Cys?Ala?Gly?Thr?Phe?Thr?Thr?Ile

25 30 35

tcc?gcc?tgg?gtg?caa?ggc?cta?gaa?agc?tac?gac?cgc?gac?gcg?atc?cac 259

Ser?Ala?Trp?Val?Gln?Gly?Leu?Glu?Ser?Tyr?Asp?Arg?Asp?Ala?Ile?His

40 45 50

ctc?tct?gca?ctc?aac?ttc?gat?gca?ctg?cga?gtt?gtc?acc?gat?gag?atc 307

Leu?Ser?Ala?Leu?Asn?Phe?Asp?Ala?Leu?Arg?Val?Val?Thr?Asp?Glu?Ile

55 60 65

att?tca?gaa?tca?tca?tca?cag?cgc?gcc?agc?aac?cca?gtt?gtt?gat?cca 355

Ile?Ser?Glu?Ser?Ser?Ser?Gln?Arg?Ala?Ser?Asn?Pro?Val?Val?Asp?Pro

70 75 80 85

ggt?cgc?gcc?gac?gtc?atc?ggt?ggc?gga?tcc?gtt?gtt?gtc?caa?gca?gcg 403

Gly?Arg?Ala?Asp?Val?Ile?Gly?Gly?Gly?Ser?Val?Val?Val?Gln?Ala?Ala

90 95 100

atc?gac?tta?gcc?tcc?aaa?gaa?gcc?ggt?gta?gac?tac?atc?att?att?tcc 451

Ile?Asp?Leu?Ala?Ser?Lys?Glu?Ala?Gly?Val?Asp?Tyr?Ile?Ile?Ile?Ser

105 110 115

gaa?aaa?gac?atc?ctc?gac?ggc?ctc?atc?ctt?ggc?ctg?gta?gaa?gcc?gac 499

Glu?Lys?Asp?Ile?Leu?Asp?Gly?Leu?Ile?Leu?Gly?Leu?Val?Glu?Ala?Asp

120 125 130

tct?ttg?aag?aaa?taggacccta?gttttaaacc?act 534

Ser?Leu?Lys?Lys

135

<210>338

<211>137

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>338

Val?Glu?Ile?Ala?Arg?Asp?Tyr?Val?Ala?Glu?Arg?Ile?Gln?Glu?Val?Lys

1 5 10 15

Ala?Ile?Val?Pro?Ile?Ser?Lys?Ala?Lys?Thr?Phe?Val?Gly?Cys?Ala?Gly

20 25 30

Thr?Phe?Thr?Thr?Ile?Ser?Ala?Trp?Val?Gln?Gly?Leu?Glu?Ser?Tyr?Asp

35 40 45

Arg?Asp?Ala?Ile?His?Leu?Ser?Ala?Leu?Asn?Phe?Asp?Ala?Leu?Arg?Val

50 55 60

Val?Thr?Asp?Glu?Ile?Ile?Ser?Glu?Ser?Ser?Ser?Gln?Arg?Ala?Ser?Asn

65 70 75 80

Pro?Val?Val?Asp?Pro?Gly?Arg?Ala?Asp?Val?Ile?Gly?Gly?Gly?Ser?Val

85 90 95

Val?Val?Gln?Ala?Ala?Ile?Asp?Leu?Ala?Ser?Lys?Glu?Ala?Gly?Val?Asp

100 105 110

Tyr?Ile?Ile?Ile?Ser?Glu?Lys?Asp?Ile?Leu?Asp?Gly?Leu?Ile?Leu?Gly

115 120 125

Leu?Val?Glu?Ala?Asp?Ser?Leu?Lys?Lys

130 135

<210>339

<211>1497

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1474)

<223>RXN00663

<400>339

ctgaacgatt?ggtgaccggc?tcatgaaaac?ttgacgagtc?cccggtattc?gccagcggtg?60

actactaccg?tgggcgacaa?gcccacttag?aggaggactt?gtg?aca?acc?acc?tat 115

Val?Thr?Thr?Thr?Tyr

1 5

cca?gat?ttc?ctt?gga?aat?tct?tcg?ctc?caa?aca?gat?acg?gag?cac?tgg 163

Pro?Asp?Phe?Leu?Gly?Asn?Ser?Ser?Leu?Gln?Thr?Asp?Thr?Glu?His?Trp

10 15 20

gaa?atg?gaa?gga?ggt?gcg?cag?gaa?gtc?tct?gtt?act?tat?gtt?ttg?gac 211

Glu?Met?Glu?Gly?Gly?Ala?Gln?Glu?Val?Ser?Val?Thr?Tyr?Val?Leu?Asp

25 30 35

acg?tca?gtg?ttg?ctg?tct?gat?ccg?ttg?tcg?ttg?aca?cgg?ttc?gcg?gag 259

Thr?Ser?Val?Leu?Leu?Ser?Asp?Pro?Leu?Ser?Leu?Thr?Arg?Phe?Ala?Glu

40 45 50

cac?gat?gta?gtt?ctg?cca?att?gtt?gta?att?acg?gaa?tta?gaa?gcc?aag 307

His?Asp?Val?Val?Leu?Pro?Ile?Val?Val?Ile?Thr?Glu?Leu?Glu?Ala?Lys

55 60 65

cgt?cat?cac?ccg?gac?ctt?ggc?ttt?ttt?gct?cgc?caa?gcg?ctt?cgg?atg 355

Arg?His?His?Pro?Asp?Leu?Gly?Phe?Phe?Ala?Arg?Gln?Ala?Leu?Arg?Met

70 75 80 85

ctg?gat?gag?ctg?cgt?gag?atc?cat?ggg?gat?ttg?tcc?aag?cca?ctg?cca 403

Leu?Asp?Glu?Leu?Arg?Glu?Ile?His?Gly?Asp?Leu?Ser?Lys?Pro?Leu?Pro

90 95 100

att?ggc?gat?gaa?ggc?gga?cac?atc?cat?gtt?gag?ctg?aat?cac?caa?aac 451

Ile?Gly?Asp?Glu?Gly?Gly?His?Ile?His?Val?Glu?Leu?Asn?His?Gln?Asn

105 110 115

acg?ggg?tcc?ttg?ccc?gtg?gga?ttc?cgc?ctt?ggt?gac?aat?gac?acc?cgc 499

Thr?Gly?Ser?Leu?Pro?Val?Gly?Phe?Arg?Leu?Gly?Asp?Asn?Asp?Thr?Arg

120 125 130

atc?ctt?gca?gtg?gcc?aag?aat?ctg?cag?gaa?gag?ggc?cac?aat?gtg?gtt 547

Ile?Leu?Ala?Val?Ala?Lys?Asn?Leu?Gln?Glu?Glu?Gly?His?Asn?Val?Val

135 140 145

ctg?gtg?tcg?aag?gac?ctg?ccg?atg?cgg?att?aag?gcg?tcg?gca?agc?gga 595

Leu?Val?Ser?Lys?Asp?Leu?Pro?Met?Arg?Ile?Lys?Ala?Ser?Ala?Ser?Gly

150 155 160 165

atc?gcc?gca?cag?gaa?tac?cgc?gct?gcc?ctg?gcg?cgc?gac?cgt?ggt?tac 643

Ile?Ala?Ala?Gln?Glu?Tyr?Arg?Ala?Ala?Leu?Ala?Arg?Asp?Arg?Gly?Tyr

170 175 180

acc?ggc?atg?acc?cac?gcc?aat?atc?acc?gat?gac?cag?ctc?agc?gag?ctc 691

Thr?Gly?Met?Thr?His?Ala?Asn?Ile?Thr?Asp?Asp?Gln?Leu?Ser?Glu?Leu

185 190 195

tac?gac?acc?ggc?gag?gtg?cgc?att?gag?gag?ctc?gaa?aag?ctg?ccc?gtc 739

Tyr?Asp?Thr?Gly?Glu?Val?Arg?Ile?Glu?Glu?Leu?Glu?Lys?Leu?Pro?Val

200 205 210

aac?cac?ggc?ttc?acc?ctc?aaa?tcc?aac?agc?ggt?tcg?gcg?ctt?ggt?cgt 787

Asn?His?Gly?Phe?Thr?Leu?Lys?Ser?Asn?Ser?Gly?Ser?Ala?Leu?Gly?Arg

215 220 225

atg?aat?tcc?gac?aag?atc?atc?gag?ctt?gtc?ccc?ggc?gac?cag?cag?gta 835

Met?Asn?Ser?Asp?Lys?Ile?Ile?Glu?Leu?Val?Pro?Gly?Asp?Gln?Gln?Val

230 235 240 245

ttc?ggt?atc?agc?ggg?cgt?agc?gct?gag?cag?cgg?gtt?gcc?att?gat?ttg 883

Phe?Gly?Ile?Ser?Gly?Arg?Ser?Ala?Glu?Gln?Arg?Val?Ala?Ile?Asp?Leu

250 255 260

ctt?aac?gac?gac?gcc?gtc?ggc?atc?gta?tcc?atc?ggc?ggc?ccc?gcg?ggt 931

Leu?Asn?Asp?Asp?Ala?Val?Gly?Ile?Val?Ser?Ile?Gly?Gly?Pro?Ala?Gly

265 270 275

aca?ggt?aaa?agc?gca?ctc?gca?ctg?tgt?gcc?ggc?ctg?gaa?gct?gtg?atg 979

Thr?Gly?Lys?Ser?Ala?Leu?Ala?Leu?Cys?Ala?Gly?Leu?Glu?Ala?Val?Met

280 285 290

gag?cgt?cgc?att?cag?cgc?aag?att?atc?gtg?ttc?cgc?cca?ctc?ttt?gcc 1027

Glu?Arg?Arg?Ile?Gln?Arg?Lys?Ile?Ile?Val?Phe?Arg?Pro?Leu?Phe?Ala

295 300 305

gtt?ggc?gga?cag?gaa?ctt?ggc?tac?ctg?cct?ggc?gac?caa?gaa?gaa?aaa 1075

Val?Gly?Gly?Gln?Glu?Leu?Gly?Tyr?Leu?Pro?Gly?Asp?Gln?Glu?Glu?Lys

310 315 320 325

atg?ggg?cct?tgg?gcg?caa?gcg?gtt?ttt?gac?acc?cta?agc?tcc?atg?gtc 1123

Met?Gly?Pro?Trp?Ala?Gln?Ala?Val?Phe?Asp?Thr?Leu?Ser?Ser?Met?Val

330 335 340

agc?caa?aac?atc?atc?gat?gaa?gcc?ctc?tcc?cgc?ggc?ctc?atc?gaa?gtt 1171

Ser?Gln?Asn?Ile?Ile?Asp?Glu?Ala?Leu?Ser?Arg?Gly?Leu?Ile?Glu?Val

345 350 355

ctc?cca?ctt?act?cac?atc?cgc?gga?cgc?tca?ctc?cac?gat?gct?ttc?gtc 1219

Leu?Pro?Leu?Thr?His?Ile?Arg?Gly?Arg?Ser?Leu?His?Asp?Ala?Phe?Val

360 365 370

atc?gtc?gac?gag?gcc?caa?tcc?cta?gaa?cgc?aac?gtg?ttg?ctc?acc?atg 1267

Ile?Val?Asp?Glu?Ala?Gln?Ser?Leu?Glu?Arg?Asn?Val?Leu?Leu?Thr?Met

375 380 385

ctg?tct?cgc?atc?ggc?cag?aat?tcc?cga?gta?gtt?ctc?acc?cat?gac?gta 1315

Leu?Ser?Arg?Ile?Gly?Gln?Asn?Ser?Arg?Val?Val?Leu?Thr?His?Asp?Val

390 395 400 405

gcg?cag?cgc?gac?aac?ctg?cgc?gtt?ggt?cgc?tac?gac?ggc?atc?gtc?tct 1363

Ala?Gln?Arg?Asp?Asn?Leu?Arg?Val?Gly?Arg?Tyr?Asp?Gly?Ile?Val?Ser

410 415 420

gtg?gtg?gaa?gca?ctc?aag?gat?cac?gaa?ctg?ttt?ggc?cac?atc?acg?ttg 1411

Val?Val?Glu?Ala?Leu?Lys?Asp?His?Glu?Leu?Phe?Gly?His?Ile?Thr?Leu

425 430 435

cag?cgt?tcc?gaa?cgc?tcc?cga?atc?gct?gag?ttg?gtc?acc?caa?gtt?ttg 1459

Gln?Arg?Ser?Glu?Arg?Ser?Arg?Ile?Ala?Glu?Leu?Val?Thr?Gln?Val?Leu

440 445 450

gat?gcg?ccg?tct?ctg?tagtcgcgca?gtctgtggcg?att 1497

Asp?Ala?Pro?Ser?Leu

455

<210>340

<211>458

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>340

Val?Thr?Thr?Thr?Tyr?Pro?Asp?Phe?Leu?Gly?Asn?Ser?Ser?Leu?Gln?Thr

1 5 10 15

Asp?Thr?Glu?His?Trp?Glu?Met?Glu?Gly?Gly?Ala?Gln?Glu?Val?Ser?Val

20 25 30

Thr?Tyr?Val?Leu?Asp?Thr?Ser?Val?Leu?Leu?Ser?Asp?Pro?Leu?Ser?Leu

35 40 45

Thr?Arg?Phe?Ala?Glu?His?Asp?Val?Val?Leu?Pro?Ile?Val?Val?Ile?Thr

50 55 60

Glu?Leu?Glu?Ala?Lys?Arg?His?His?Pro?Asp?Leu?Gly?Phe?Phe?Ala?Arg

65 70 75 80

Gln?Ala?Leu?Arg?Met?Leu?Asp?Glu?Leu?Arg?Glu?Ile?His?Gly?Asp?Leu

85 90 95

Ser?Lys?Pro?Leu?Pro?Ile?Gly?Asp?Glu?Gly?Gly?His?Ile?His?Val?Glu

100 105 110

Leu?Asn?His?Gln?Asn?Thr?Gly?Ser?Leu?Pro?Val?Gly?Phe?Arg?Leu?Gly

115 120 125

Asp?Asn?Asp?Thr?Arg?Ile?Leu?Ala?Val?Ala?Lys?Asn?Leu?Gln?Glu?Glu

130 135 140

Gly?His?Asn?Val?Val?Leu?Val?Ser?Lys?Asp?Leu?Pro?Met?Arg?Ile?Lys

145 150 155 160

Ala?Ser?Ala?Ser?Gly?Ile?Ala?Ala?Gln?Glu?Tyr?Arg?Ala?Ala?Leu?Ala

165 170 175

Arg?Asp?Arg?Gly?Tyr?Thr?Gly?Met?Thr?His?Ala?Asn?Ile?Thr?Asp?Asp

180 185 190

Gln?Leu?Ser?Glu?Leu?Tyr?Asp?Thr?Gly?Glu?Val?Arg?Ile?Glu?Glu?Leu

195 200 205

Glu?Lys?Leu?Pro?Val?Asn?His?Gly?Phe?Thr?Leu?Lys?Ser?Asn?Ser?Gly

210 215 220

Ser?Ala?Leu?Gly?Arg?Met?Asn?Ser?Asp?Lys?Ile?Ile?Glu?Leu?Val?Pro

225 230 235 240

Gly?Asp?Gln?Gln?Val?Phe?Gly?Ile?Ser?Gly?Arg?Ser?Ala?Glu?Gln?Arg

245 250 255

Val?Ala?Ile?Asp?Leu?Leu?Asn?Asp?Asp?Ala?Val?Gly?Ile?Val?Ser?Ile

260 265 270

Gly?Gly?Pro?Ala?Gly?Thr?Gly?Lys?Ser?Ala?Leu?Ala?Leu?Cys?Ala?Gly

275 280 285

Leu?Glu?Ala?Val?Met?Glu?Arg?Arg?Ile?Gln?Arg?Lys?Ile?Ile?Val?Phe

290 295 300

Arg?Pro?Leu?Phe?Ala?Val?Gly?Gly?Gln?Glu?Leu?Gly?Tyr?Leu?Pro?Gly

305 310 315 320

Asp?Gln?Glu?Glu?Lys?Met?Gly?Pro?Trp?Ala?Gln?Ala?Val?Phe?Asp?Thr

325 330 335

Leu?Ser?Ser?Met?Val?Ser?Gln?Asn?Ile?Ile?Asp?Glu?Ala?Leu?Ser?Arg

340 345 350

Gly?Leu?Ile?Glu?Val?Leu?Pro?Leu?Thr?His?Ile?Arg?Gly?Arg?Ser?Leu

355 360 365

His?Asp?Ala?Phe?Val?Ile?Val?Asp?Glu?Ala?Gln?Ser?Leu?Glu?Arg?Asn

370 375 380

Val?Leu?Leu?Thr?Met?Leu?Ser?Arg?Ile?Gly?Gln?Asn?Ser?Arg?Val?Val

385 390 395 400

Leu?Thr?His?Asp?Val?Ala?Gln?Arg?Asp?Asn?Leu?Arg?Val?Gly?Arg?Tyr

405 410 415

Asp?Gly?Ile?Val?Ser?Val?Val?Glu?Ala?Leu?Lys?Asp?His?Glu?Leu?Phe

420 425 430

Gly?His?Ile?Thr?Leu?Gln?Arg?Ser?Glu?Arg?Ser?Arg?Ile?Ala?Glu?Leu

435 440 445

Val?Thr?Gln?Val?Leu?Asp?Ala?Pro?Ser?Leu

450 455

<210>341

<211>1248

<212>DNA

＜2l3〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1225)

<223>RXN00778

<400>341

aggtcttagg?tttttaagtc?gtgagcaatc?cggagggaaa?ctagcccgcc?tacaggatct?60

gctcagacga?tgtcttcact?taaaccggaa?aggcttcccc?gtg?aac?ctc?act?ctt 115

Val?Asn?Leu?Thr?Leu

1 5

aag?cgc?tcc?atc?gcc?ctt?gtg?ggc?gca?gtt?act?gca?ggc?tcc?ttc?gct 163

Lys?Arg?Ser?Ile?Ala?Leu?Val?Gly?Ala?Val?Thr?Ala?Gly?Ser?Phe?Ala

10 15 20

ctt?gta?gct?tgc?tcc?gac?tcc?aat?gag?tct?gat?tcc?acc?tcc?tea?tct 211

Leu?Val?Ala?Cys?Ser?Asp?Ser?Asn?Glu?Ser?Asp?Ser?Thr?Ser?Ser?Ser

25 30 35

gca?gct?tcc?acc?ggt?tct?tcc?gat?gct?gca?tcc?att?gag?ggc?ctt?tcc 259

Ala?Ala?Ser?Thr?Gly?Ser?Ser?Asp?Ala?Ala?Ser?Ile?Glu?Gly?Leu?Ser

40 45 50

ggt?gtt?acc?ggt?cag?ctc?gtt?gct?gaa?ggt?gca?tct?tcc?cag?cag?tcc 307

Gly?Val?Thr?Gly?Gln?Leu?Val?Ala?Glu?Gly?Ala?Ser?Ser?Gln?Gln?Ser

55 60 65

gca?atg?gac?tac?ttt?ggt?atc?cgt?tac?tcc?gag?gct?gtc?agc?ggt?gca 355

Ala?Met?Asp?Tyr?Phe?Gly?Ile?Arg?Tyr?Ser?Glu?Ala?Val?Ser?Gly?Ala

70 75 80 85

tct?ctg?gct?tac?acc?cct?tca?ggt?tcc?ggt?tcc?ggc?cgc?acc?aac?ttc 403

Ser?Leu?Ala?Tyr?Thr?Pro?Ser?Gly?Ser?Gly?Ser?Gly?Arg?Thr?Asn?Phe

90 95 100

gct?gca?ggc?cag?gtt?gct?ttc?ggt?ggc?tcc?gac?tcc?gca?atg?aag?gac 451

Ala?Ala?Gly?Gln?Val?Ala?Phe?Gly?Gly?Ser?Asp?Ser?Ala?Met?Lys?Asp

105 110 115

gac?cag?gct?gca?gaa?gca?gaa?gca?cgt?tgc?aac?ggc?aac?gaa?gca?tgg 499

Asp?Gln?Ala?Ala?Glu?Ala?Glu?Ala?Arg?Cys?Asn?Gly?Asn?Glu?Ala?Trp

120 125 130

cac?ctg?cca?ttc?gtt?atc?ggc?cca?gtt?gca?gtt?gct?tac?aac?ctg?cct 547

His?Leu?Pro?Phe?Val?Ile?Gly?Pro?Val?Ala?Val?Ala?Tyr?Asn?Leu?Pro

135 140 145

ggc?gtt?gac?acc?ctg?aac?ctg?gac?acc?aac?atc?atc?gct?cag?atc?ttc 595

Gly?Val?Asp?Thr?Leu?Asn?Leu?Asp?Thr?Asn?Ile?Ile?Ala?Gln?Ile?Phe

150 155 160 165

aag?ggc?gag?atc?acc?aag?tgg?aac?gac?gaa?gca?atc?gct?tcc?cag?aac 643

Lys?Gly?Glu?Ile?Thr?Lys?Trp?Asn?Asp?Glu?Ala?Ile?Ala?Ser?Gln?Asn

170 175 180

gag?ggc?acc?gac?ctc?cca?gac?cag?gac?atc?tcc?gtt?ctg?tac?cgt?tcc 691

Glu?Gly?Thr?Asp?Leu?Pro?Asp?Gln?Asp?Ile?Ser?Val?Leu?Tyr?Arg?Ser

185 190 195

gaa?gag?tcc?ggt?acc?tcc?gac?aac?ttc?cag?aag?ttc?ctc?gga?gct?tcc 739

Glu?Glu?Ser?Gly?Thr?Ser?Asp?Asn?Phe?Gln?Lys?Phe?Leu?Gly?Ala?Ser

200 205 210

acc?gac?atc?tgg?gag?acc?gaa?ggc?cag?cag?ttc?cca?acc?gag?gtt?ggc 787

Thr?Asp?Ile?Trp?Glu?Thr?Glu?Gly?Gln?Gln?Phe?Pro?Thr?Glu?Val?Gly

215 220 225

tcc?ggt?gcg?cag?ggc?tcc?aac?ggt?gta?gct?tct?gag?gct?tcc?aac?atc 835

Ser?Gly?Ala?Gln?Gly?Ser?Asn?Gly?Val?Ala?Ser?Glu?Ala?Ser?Asn?Ile

230 235 240 245

gag?ggt?gca?atc?acc?tac?gtt?gaa?gct?ggt?ttc?gct?aac?cag?tcc?ggc 883

Glu?Gly?Ala?Ile?Thr?Tyr?Val?Glu?Ala?Gly?Phe?Ala?Asn?Gln?Ser?Gly

250 255 260

ctg?ggc?gtt?gca?aac?atc?gac?ttc?ggt?tcc?ggc?cca?gtt?gaa?ctc?aac 931

Leu?Gly?Val?Ala?Asn?Ile?Asp?Phe?Gly?Ser?Gly?Pro?Val?Glu?Leu?Asn

265 270 275

gct?gag?tcc?gtt?ggc?gtt?gca?ctt?ggt?gca?ctc?gac?ttc?ctg?act?gag 979

Ala?Glu?Ser?Val?Gly?Val?Ala?Leu?Gly?Ala?Leu?Asp?Phe?Leu?Thr?Glu

280 285 290

ggc?cac?aac?atg?gtt?gtt?gac?acc?gac?gct?atg?ttc?gca?atg?aac?gaa 1027

Gly?His?Asn?Met?Val?Val?Asp?Thr?Asp?Ala?Met?Phe?Ala?Met?Asn?Glu

295 300 305

gcc?ggt?gct?tac?cca?ctg?atc?ctc?acc?acc?tac?gaa?atc?gtc?tgc?tcc 1075

Ala?Gly?Ala?Tyr?Pro?Leu?Ile?Leu?Thr?Thr?Tyr?Glu?Ile?Val?Cys?Ser

310 315 320 325

gca?ggc?tac?gac?gag?acc?acc?cgc?gac?cag?gtc?aag?gac?ttc?ctg?acc 1123

Ala?Gly?Tyr?Asp?Glu?Thr?Thr?Arg?Asp?Gln?Val?Lys?Asp?Phe?Leu?Thr

330 335 340

gtt?gca?ctg?gac?tcc?cag?gat?gac?cag?ctc?gag?gct?ctc?ggc?tac?atc 1171

Val?Ala?Leu?Asp?Ser?Gln?Asp?Asp?Gln?Leu?Glu?Ala?Leu?Gly?Tyr?Ile

345 350 355

cca?gtt?acc?ggc?gag?cac?tac?gat?cgc?ctc?gtt?gca?gca?gtt?gaa?gca 1219

Pro?Val?Thr?Gly?Glu?His?Tyr?Asp?Arg?Leu?Val?Ala?Ala?Val?Glu?Ala

360 365 370

att?cag?taataaaccg?ctgccgtagc?ttc 1248

Ile?Gln

375

<210>342

<211>375

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>342

Val?Asn?Leu?Thr?Leu?Lys?Arg?Ser?Ile?Ala?Leu?Val?Gly?Ala?Val?Thr

1 5 10 15

Ala?Gly?Ser?Phe?Ala?Leu?Val?Ala?Cys?Ser?Asp?Ser?Asn?Glu?Ser?Asp

20 25 30

Ser?Thr?Ser?Ser?Ser?Ala?Ala?Ser?Thr?Gly?Ser?Ser?Asp?Ala?Ala?Ser

35 40 45

Ile?Glu?Gly?Leu?Ser?Gly?Val?Thr?Gly?Gln?Leu?Val?Ala?Glu?Gly?Ala

50 55 60

Ser?Ser?Gln?Gln?Ser?Ala?Met?Asp?Tyr?Phe?Gly?Ile?Arg?Tyr?Ser?Glu

65 70 75 80

Ala?Val?Ser?Gly?Ala?Ser?Leu?Ala?Tyr?Thr?Pro?Ser?Gly?Ser?Gly?Ser

85 90 95

Gly?Arg?Thr?Asn?Phe?Ala?Ala?Gly?Gln?Val?Ala?Phe?Gly?Gly?Ser?Asp

100 105 110

Ser?Ala?Met?Lys?Asp?Asp?Gln?Ala?Ala?Glu?Ala?Glu?Ala?Arg?Cys?Asn

115 120 125

Gly?Asn?Glu?Ala?Trp?His?Leu?Pro?Phe?Val?Ile?Gly?Pro?Val?Ala?Val

130 135 140

Ala?Tyr?Asn?Leu?Pro?Gly?Val?Asp?Thr?Leu?Asn?Leu?Asp?Thr?Asn?Ile

145 150 155 160

Ile?Ala?Gln?Ile?Phe?Lys?Gly?Glu?Ile?Thr?Lys?Trp?Asn?Asp?Glu?Ala

165 170 175

Ile?Ala?Ser?Gln?Asn?Glu?Gly?Thr?Asp?Leu?Pro?Asp?Gln?Asp?Ile?Ser

180 185 190

Val?Leu?Tyr?Arg?Ser?Glu?Glu?Ser?Gly?Thr?Ser?Asp?Asn?Phe?Gln?Lys

195 200 205

Phe?Leu?Gly?Ala?Ser?Thr?Asp?Ile?Trp?Glu?Thr?Glu?Gly?Gln?Gln?Phe

210 215 220

Pro?Thr?Glu?Val?Gly?Ser?Gly?Ala?Gln?Gly?Ser?Asn?Gly?Val?Ala?Ser

225 230 235 240

Glu?Ala?Ser?Asn?Ile?Glu?Gly?Ala?Ile?Thr?Tyr?Val?Glu?Ala?Gly?Phe

245 250 255

Ala?Asn?Gln?Ser?Gly?Leu?Gly?Val?Ala?Asn?Ile?Asp?Phe?Gly?Ser?Gly

260 265 270

Pro?Val?Glu?Leu?Asn?Ala?Glu?Ser?Val?Gly?Val?Ala?Leu?Gly?Ala?Leu

275 280 285

Asp?Phe?Leu?Thr?Glu?Gly?His?Asn?Met?Val?Val?Asp?Thr?Asp?Ala?Met

290 295 300

Phe?Ala?Met?Asn?Glu?Ala?Gly?Ala?Tyr?Pro?Leu?Ile?Leu?Thr?Thr?Tyr

305 310 315 320

Glu?Ile?Val?Cys?Ser?Ala?Gly?Tyr?Asp?Glu?Thr?Thr?Arg?Asp?Gln?Val

325 330 335

Lys?Asp?Phe?Leu?Thr?Val?Ala?Leu?Asp?Ser?Gln?Asp?Asp?Gln?Leu?Glu

340 345 350

Ala?Leu?Gly?Tyr?Ile?Pro?Val?Thr?Gly?Glu?His?Tyr?Asp?Arg?Leu?Val

355 360 365

Ala?Ala?Val?Glu?Ala?Ile?Gln

370 375

<210>343

<211>870

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(847)

<223>RXN00250

<400>343

acaacaccag?accaccccaa?ccctgaataa?acccctattt?ttctaaaaag?tcacactttg?60

ccgtatagaa?attcagtcaa?ccaagagtac?tctgtccacc?atg?gtt?ttt?act?ctt 115

Met?Val?Phe?Thr?Leu

1 5

gcg?gac?tcc?gtc?tcc?cag?gtt?gcg?cta?ggt?ccg?tcc?tgg?ctg?gac?cct 163

Ala?Asp?Ser?Val?Ser?Gln?Val?Ala?Leu?Gly?Pro?Ser?Trp?Leu?Asp?Pro

10 15 20

atg?gaa?ctt?ctt?tcc?ggc?tcc?ggc?ccg?ttc?ggt?agc?ttc?att?ctt?ccg 211

Met?Glu?Leu?Leu?Ser?Gly?Ser?Gly?Pro?Phe?Gly?Ser?Phe?Ile?Leu?Pro

25 30 35

gcg?atg?ctt?gcc?att?gtc?ttt?atc?gaa?tca?ggc?cta?ctt?ttc?cca?ctt 259

Ala?Met?Leu?Ala?Ile?Val?Phe?Ile?Glu?Ser?Gly?Leu?Leu?Phe?Pro?Leu

40 45 50

cta?cca?ggt?gat?tct?ctc?ctt?ttc?acc?ggt?ggt?ctc?cta?gct?aac?cag 307

Leu?Pro?Gly?Asp?Ser?Leu?Leu?Phe?Thr?Gly?Gly?Leu?Leu?Ala?Asn?Gln

55 60 65

gct?gac?cct?ttt?gca?ccg?ctg?tgg?ctg?gtg?ctg?atc?ctc?tgc?cct?atc 355

Ala?Asp?Pro?Phe?Ala?Pro?Leu?Trp?Leu?Val?Leu?Ile?Leu?Cys?Pro?Ile

70 75 80 85

gcc?gca?att?ctt?ggc?gat?cag?gtg?ggt?tac?tgg?att?ggc?cac?aag?ttc 403

Ala?Ala?Ile?Leu?Gly?Asp?Gln?Val?Gly?Tyr?Trp?Ile?Gly?His?Lys?Phe

90 95 100

cac?cct?cgc?ctg?gtc?aat?cgt?ccg?gat?ggc?agg?att?ttc?aag?cag?gaa 451

His?Pro?Arg?Leu?Val?Asn?Arg?Pro?Asp?Gly?Arg?Ile?Phe?Lys?Gln?Glu

105 110 115

tac?ctc?aag?cag?act?gag?gat?ttc?ttt?gag?aag?cat?ggc?ccc?gtg?acg 499

Tyr?Leu?Lys?Gln?Thr?Glu?Asp?Phe?Phe?Glu?Lys?His?Gly?Pro?Val?Thr

120 125 130

atc?att?ttg?tgc?cgt?ttc?gtg?ccc?atc?gtc?cgt?act?tac?gca?cct?ctg 547

Ile?Ile?Leu?Cys?Arg?Phe?Val?Pro?Ile?Val?Arg?Thr?Tyr?Ala?Pro?Leu

135 140 145

gtc?gca?ggt?atg?gct?ggc?atg?cgt?tac?cgc?acg?ttc?att?att?tac?aac 595

Val?Ala?Gly?Met?Ala?Gly?Met?Arg?Tyr?Arg?Thr?Phe?Ile?Ile?Tyr?Asn

150 155 160 165

atg?atc?ggt?ggc?att?ttg?tgg?ggt?tcc?ggc?gtg?gtg?gct?ttg?ggt?gct 643

Met?Ile?Gly?Gly?Ile?Leu?Trp?Gly?Ser?Gly?Val?Val?Ala?Leu?Gly?Ala

170 175 180

gcg?ttg?ggt?cag?ttc?gat?ttc?gtc?cgc?aac?aat?att?gat?ctg?att?ttc 691

Ala?Leu?Gly?Gln?Phe?Asp?Phe?Val?Arg?Asn?Asn?Ile?Asp?Leu?Ile?Phe

185 190 195

ttg?ctg?atc?gtg?ttc?att?tcg?gtg?gtt?cct?ggt?ttg?gtc?ggc?atg?gcc 739

Leu?Leu?Ile?Val?Phe?Ile?Ser?Val?Val?Pro?Gly?Leu?Val?Gly?Met?Ala

200 205 210

cgc?aag?ctg?gct?gac?ggc?cac?aag?caa?gcc?aac?acc?gag?cca?caa?gaa 787

Arg?Lys?Leu?Ala?Asp?Gly?His?Lys?Gln?Ala?Asn?Thr?Glu?Pro?Gln?Glu

215 220 225

aac?ccc?gca?gtc?cag?aca?gcc?cca?gta?aaa?acc?cag?gaa?gcc?cag?gaa 835

Asn?Pro?Ala?Val?Gln?Thr?Ala?Pro?Val?Lys?Thr?Gln?Glu?Ala?Gln?Glu

230 235 240 245

gcc?ccc?cag?aac?taatctttcc?ggtccgccag?ttc 870

Ala?Pro?Gln?Asn

<210>344

<211>249

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>344

Met?Val?Phe?Thr?Leu?Ala?Asp?Ser?Val?Ser?Gln?Val?Ala?Leu?Gly?Pro

1 5 10 15

Ser?Trp?Leu?Asp?Pro?Met?Glu?Leu?Leu?Ser?Gly?Ser?Gly?Pro?Phe?Gly

20 25 30

Ser?Phe?Ile?Leu?Pro?Ala?Met?Leu?Ala?Ile?Val?Phe?Ile?Glu?Ser?Gly

35 40 45

Leu?Leu?Phe?Pro?Leu?Leu?Pro?Gly?Asp?Ser?Leu?Leu?Phe?Thr?Gly?Gly

50 55 60

Leu?Leu?Ala?Asn?Gln?Ala?Asp?Pro?Phe?Ala?Pro?Leu?Trp?Leu?Val?Leu

65 70 75 80

Ile?Leu?Cys?Pro?Ile?Ala?Ala?Ile?Leu?Gly?Asp?Gln?Val?Gly?Tyr?Trp

85 90 95

Ile?Gly?His?Lys?Phe?His?Pro?Arg?Leu?Val?Asn?Arg?Pro?Asp?Gly?Arg

100 105 110

Ile?Phe?Lys?Gln?Glu?Tyr?Leu?Lys?Gln?Thr?Glu?Asp?Phe?Phe?Glu?Lys

115 120 125

His?Gly?Pro?Val?Thr?Ile?Ile?Leu?Cys?Arg?Phe?Val?Pro?Ile?Val?Arg

130 135 140

Thr?Tyr?Ala?Pro?Leu?Val?Ala?Gly?Met?Ala?Gly?Met?Arg?Tyr?Arg?Thr

145 150 155 160

Phe?Ile?Ile?Tyr?Asn?Met?Ile?Gly?Gly?Ile?Leu?Trp?Gly?Ser?Gly?Val

165 170 175

Val?Ala?Leu?Gly?Ala?Ala?Leu?Gly?Gln?Phe?Asp?Phe?Val?Arg?Asn?Asn

180 185 190

Ile?Asp?Leu?Ile?Phe?Leu?Leu?Ile?Val?Phe?Ile?Ser?Val?Val?Pro?Gly

195 200 205

Leu?Val?Gly?Met?Ala?Arg?Lys?Leu?Ala?Asp?Gly?His?Lys?Gln?Ala?Asn

210 215 220

Thr?Glu?Pro?Gln?Glu?Asn?Pro?Ala?Val?Gln?Thr?Ala?Pro?Val?Lys?Thr

225 230 235 240

Gln?Glu?Ala?Gln?Glu?Ala?Pro?Gln?Asn

245

<210>345

<211>541

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(541)

<223>RXA00072

<400>345

acggccagga?cgatceagtg?cacaggccag?caccagcaaa?gtccacatcg?caagcattaa?60

aagaatctct?cgaaagacac?aaaagaggtg?agtcgcaaca?atg?agc?ttt?caa?cta 115

Met?Ser?Phe?Gln?Leu

1 5

gtt?aac?gcc?ctg?aaa?aat?act?ggt?tcg?gta?aaa?gat?ccc?gag?atc?tca 163

Val?Asn?Ala?Leu?Lys?Asn?Thr?Gly?Ser?Val?Lys?Asp?Pro?Glu?Ile?Ser

10 15 20

ccc?gaa?gga?cct?cgc?acg?acc?aca?ccg?ttg?tca?cca?gag?gta?gca?aaa 211

Pro?Glu?Gly?Pro?Arg?Thr?Thr?Thr?Pro?Leu?Ser?Pro?Glu?Val?Ala?Lys

25 30 35

cat?aac?gag?gaa?ctc?gtc?gaa?aag?cat?gct?gct?gcg?ttg?tat?gac?gcc 259

His?Asn?Glu?Glu?Leu?Val?Glu?Lys?His?Ala?Ala?Ala?Leu?Tyr?Asp?Ala

40 45 50

agc?gcg?caa?gag?atc?ctg?gaa?tgg?aca?gcc?gag?cac?gcg?ccg?ggc?gct 307

Ser?Ala?Gln?Glu?Ile?Leu?Glu?Trp?Thr?Ala?Glu?His?Ala?Pro?Gly?Ala

55 60 65

att?gca?gtg?acc?ttg?agc?atg?gaa?aac?acc?gtg?ctg?gcg?gag?ctg?gct 355

Ile?Ala?Val?Thr?Leu?Ser?Met?Glu?Asn?Thr?Val?Leu?Ala?Glu?Leu?Ala

70 75 80 85

gcg?cgg?cac?ctg?ccg?gaa?gct?gat?ttc?ctc?ttt?ttg?gac?acc?ggt?tac 403

Ala?Arg?His?Leu?Pro?Glu?Ala?Asp?Phe?Leu?Phe?Leu?Asp?Thr?Gly?Tyr

90 95 100

cac?ttc?aag?gag?acc?ctt?gaa?gtt?gcc?cgt?cag?gta?gat?gag?cgc?tat 451

His?Phe?Lys?Glu?Thr?Leu?Glu?Val?Ala?Arg?Gln?Val?Asp?Glu?Arg?Tyr

105 110 115

tcc?cag?aag?ctt?gtc?acc?gcg?ctg?ccg?atc?ctc?aag?cgc?acg?gag?cag 499

Ser?Gln?Lys?Leu?Val?Thr?Ala?Leu?Pro?Ile?Leu?Lys?Arg?Thr?Glu?Gln

120 125 130

gat?tcc?att?tat?ggt?ctc?aac?ctg?tac?cgc?agc?aac?cca?gcg 541

Asp?Ser?Ile?Tyr?Gly?Leu?Asn?Leu?Tyr?Arg?Ser?Asn?Pro?Ala

135 140 145

<210>346

<211>147

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>346

Met?Ser?Phe?Gln?Leu?Val?Asn?Ala?Leu?Lys?Asn?Thr?Gly?Ser?Val?Lys

1 5 10 15

Asp?Pro?Glu?Ile?Ser?Pro?Glu?Gly?Pro?Arg?Thr?Thr?Thr?Pro?Leu?Ser

20 25 30

Pro?Glu?Val?Ala?Lys?His?Asn?Glu?Glu?Leu?Val?Glu?Lys?His?Ala?Ala

35 40 45

Ala?Leu?Tyr?Asp?Ala?Ser?Ala?Gln?Glu?Ile?Leu?Glu?Trp?Thr?Ala?Glu

50 55 60

His?Ala?Pro?Gly?Ala?Ile?Ala?Val?Thr?Leu?Ser?Met?Glu?Asn?Thr?Val

65 70 75 80

Leu?Ala?Glu?Leu?Ala?Ala?Arg?His?Leu?Pro?Glu?Ala?Asp?Phe?Leu?Phe

85 90 95

Leu?Asp?Thr?Gly?Tyr?His?Phe?Lys?Glu?Thr?Leu?Glu?Val?Ala?Arg?Gln

100 105 110

Val?Asp?Glu?Arg?Tyr?Ser?Gln?Lys?Leu?Val?Thr?Ala?Leu?Pro?Ile?Leu

115 120 125

Lys?Arg?Thr?Glu?Gln?Asp?Ser?Ile?Tyr?Gly?Leu?Asn?Leu?Tyr?Arg?Ser

130 135 140

Asn?Pro?Ala

145

<210>347

<211>1299

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1276)

<223>RXA00793

<400>347

tcgctggttt?ttagatggtt?ttcaagccag?cgagaccaca?ttagtttcac?gctggttgaa?60

acctttgaga?tcaatataga?ccgtgtggtc?tactcgagga?atg?agt?gaa?aac?aat 115

Met?Ser?Glu?Asn?Asn

1 5

ccc?act?acc?ttg?cac?tgg?ttc?cta?ccc?acc?tat?ggc?gat?tct?cgc?gga 163

Pro?Thr?Thr?Leu?His?Trp?Phe?Leu?Pro?Thr?Tyr?Gly?Asp?Ser?Arg?Gly

10 15 20

atc?aca?gcc?ggc?ggg?cat?ggc?ttc?ggc?ttc?cac?tcc?gga?agc?cgg?aca 211

Ile?Thr?Ala?Gly?Gly?His?Gly?Phe?Gly?Phe?His?Ser?Gly?Ser?Arg?Thr

25 30 35

gca?gac?ctc?gat?tac?ctc?tcc?caa?att?gcc?ctg?gcc?gct?gaa?cga?aac 259

Ala?Asp?Leu?Asp?Tyr?Leu?Ser?Gln?Ile?Ala?Leu?Ala?Ala?Glu?Arg?Asn

40 45 50

ggt?ttt?gaa?tcc?gtc?ctg?act?ccc?act?gga?ttg?tgg?tgc?gaa?gat?gcg 307

Gly?Phe?Glu?Ser?Val?Leu?Thr?Pro?Thr?Gly?Leu?Trp?Cys?Glu?Asp?Ala

55 60 65

tgg?atc?acc?acc?gca?gcg?ctg?ctg?tct?agg?aca?tca?aaa?ctg?aaa?ttc 355

Trp?Ile?Thr?Thr?Ala?Ala?Leu?Leu?Ser?Arg?Thr?Ser?Lys?Leu?Lys?Phe

70 75 80 85

ctc?gtt?gct?att?cga?cca?ggc?caa?gtt?agc?ccc?acc?atc?atc?gcg?cag 403

Leu?Val?Ala?Ile?Arg?Pro?Gly?Gln?Val?Ser?Pro?Thr?Ile?Ile?Ala?Gln

90 95 100

cag?ggt?gct?gcc?ttc?cag?aaa?ttc?tca?aat?aac?cgc?ctg?ctc?atc?aac 451

Gln?Gly?Ala?Ala?Phe?Gln?Lys?Phe?Ser?Asn?Asn?Arg?Leu?Leu?Ile?Asn

105 110 115

gtc?gtg?gtg?ggt?ggc?gaa?gac?cat?gaa?cag?cgc?gct?ttc?gct?gat?tat 499

Val?Val?Val?Gly?Gly?Glu?Asp?His?Glu?Gln?Arg?Ala?Phe?Ala?Asp?Tyr

120 125 130

tct?tcc?aaa?gag?gag?cgc?tac?cac?aag?gct?gat?gaa?acc?tta?gag?atc 547

Ser?Ser?Lys?Glu?Glu?Arg?Tyr?His?Lys?Ala?Asp?Glu?Thr?Leu?Glu?Ile

135 140 145

atc?gat?cac?cta?tgg?aac?agc?gca?gaa?cct?cta?aat?ttc?cag?ggt?gaa 595

Ile?Asp?His?Leu?Trp?Asn?Ser?Ala?Glu?Pro?Leu?Asn?Phe?Gln?Gly?Glu

150 155 160 165

ttc?ctc?agt?gtg?gaa?aac?gcg?gta?ttg?aag?gaa?cag?ccc?gag?gtt?tcc 643

Phe?Leu?Ser?Val?Glu?Asn?Ala?Val?Leu?Lys?Glu?Gln?Pro?Glu?Val?Ser

170 175 180

cca?ccg?att?tac?ttt?ggc?gga?tcc?tca?caa?ctc?ggc?atc?gaa?atc?gca 691

Pro?Pro?Ile?Tyr?Phe?Gly?Gly?Ser?Ser?Gln?Leu?Gly?Ile?Glu?Ile?Ala

185 190 195

gcc?caa?cat?tcc?gat?gtt?tat?ctc?acc?tgg?ggt?gaa?cct?gcg?gaa?aag 739

Ala?Gln?His?Ser?Asp?Val?Tyr?Leu?Thr?Trp?Gly?Glu?Pro?Ala?Glu?Lys

200 205 210

gta?gag?gag?aag?ctt?gcc?cgg?gtg?cgc?gcc?gaa?gca?gat?aag?cga?aac 787

Val?Glu?Glu?Lys?Leu?Ala?Arg?Val?Arg?Ala?Glu?Ala?Asp?Lys?Arg?Asn

215 220 225

cgc?gaa?cta?gac?tat?ggc?atc?cgc?ctg?cat?gtc?att?gct?cga?cca?act 835

Arg?Glu?Leu?Asp?Tyr?Gly?Ile?Arg?Leu?His?Val?Ile?Ala?Arg?Pro?Thr

230 235 240 245

gag?gat?gaa?gcc?tgg?tca?gtg?gct?caa?aat?ctt?ctt?gac?caa?ctt?gat 883

Glu?Asp?Glu?Ala?Trp?Ser?Val?Ala?Gln?Asn?Leu?Leu?Asp?Gln?Leu?Asp

250 255 260

cag?gaa?gag?gtt?gcc?cgc?att?cag?gaa?ggg?ctt?gcg?cgt?tct?caa?tcg 931

Gln?Glu?Glu?Val?Ala?Arg?Ile?Gln?Glu?Gly?Leu?Ala?Arg?Ser?Gln?Ser

265 270 275

gaa?ggt?cag?cgt?cgc?atg?acg?gaa?ctt?cat?gga?caa?ggg?gca?gca?ttc 979

Glu?Gly?Gln?Arg?Arg?Met?Thr?Glu?Leu?His?Gly?Gln?Gly?Ala?Ala?Phe

280 285 290

aca?gca?gga?gca?gat?gct?cgc?tcc?ctt?gaa?att?gca?ccg?aat?ctc?tgg 1027

Thr?Ala?Gly?Ala?Asp?Ala?Arg?Ser?Leu?Glu?Ile?Ala?Pro?Asn?Leu?Trp

295 300 305

gca?ggt?gtt?ggg?cta?gtc?cgc?ggt?ggc?gcc?ggc?aca?gcg?ttg?gtg?ggt 1075

Ala?Gly?Val?Gly?Leu?Val?Arg?Gly?Gly?Ala?Gly?Thr?Ala?Leu?Val?Gly

310 315 320 325

tcc?tat?gag?caa?gtc?gcg?caa?gca?att?ttg?cga?tac?cgc?gat?att?ggt 1123

Ser?Tyr?Glu?Gln?Val?Ala?Gln?Ala?Ile?Leu?Arg?Tyr?Arg?Asp?Ile?Gly

330 335 340

ctg?agc?cac?ttc?att?ttc?tcc?ggc?tat?cca?cat?ttg?gag?gaa?acc?tat 1171

Leu?Ser?His?Phe?Ile?Phe?Ser?Gly?Tyr?Pro?His?Leu?Glu?Glu?Thr?Tyr

345 350 355

cac?gtg?ggc?gaa?gga?gtg?gta?cct?gag?ctc?ctc?aaa?ttg?ggt?gtt?ccg 1219

His?Val?Gly?Glu?Gly?Val?Val?Pro?Glu?Leu?Leu?Lys?Leu?Gly?Val?Pro

360 365 370

gtg?aac?aac?cat?gaa?gaa?caa?cgc?aac?gac?gtg?gta?gcg?act?ccg?ttt 1267

Val?Asn?Asn?His?Glu?Glu?Gln?Arg?Asn?Asp?Val?Val?Ala?Thr?Pro?Phe

375 380 385

att?tcc?aga?tagatcacgg?atcggctgct?tta 1299

Ile?Ser?Arg

390

<210>348

<211>392

<2l2>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>348

Met?Ser?Glu?Asn?Asn?Pro?Thr?Thr?Leu?His?Trp?Phe?Leu?Pro?Thr?Tyr

1 5 10 15

Gly?Asp?Ser?Arg?Gly?Ile?Thr?Ala?Gly?Gly?His?Gly?Phe?Gly?Phe?His

20 25 30

Ser?Gly?Ser?Arg?Thr?Ala?Asp?Leu?Asp?Tyr?Leu?Ser?Gln?Ile?Ala?Leu

35 40 45

Ala?Ala?Glu?Arg?Asn?Gly?Phe?Glu?Ser?Val?Leu?Thr?Pro?Thr?Gly?Leu

50 55 60

Trp?Cys?Glu?Asp?Ala?Trp?Ile?Thr?Thr?Ala?Ala?Leu?Leu?Ser?Arg?Thr

65 70 75 80

Ser?Lys?Leu?Lys?Phe?Leu?Val?Ala?Ile?Arg?Pro?Gly?Gln?Val?Ser?Pro

85 90 95

Thr?Ile?Ile?Ala?Gln?Gln?Gly?Ala?Ala?Phe?Gln?Lys?Phe?Ser?Asn?Asn

100 105 110

Arg?Leu?Leu?Ile?Asn?Val?Val?Val?Gly?Gly?Glu?Asp?His?Glu?Gln?Arg

115 120 125

Ala?Phe?Ala?Asp?Tyr?Ser?Ser?Lys?Glu?Glu?Arg?Tyr?His?Lys?Ala?Asp

130 135 140

Glu?Thr?Leu?Glu?Ile?Ile?Asp?His?Leu?Trp?Asn?Ser?Ala?Glu?Pro?Leu

145 150 155 160

Asn?Phe?Gln?Gly?Glu?Phe?Leu?Ser?Val?Glu?Asn?Ala?Val?Leu?Lys?Glu

165 170 175

Gln?Pro?Glu?Val?Ser?Pro?Pro?Ile?Tyr?Phe?Gly?Gly?Ser?Ser?Gln?Leu

180 185 190

Gly?Ile?Glu?Ile?Ala?Ala?Gln?His?Ser?Asp?Val?Tyr?Leu?Thr?Trp?Gly

195 200 205

Glu?Pro?Ala?Glu?Lys?Val?Glu?Glu?Lys?Leu?Ala?Arg?Val?Arg?Ala?Glu

210 215 220

Ala?Asp?Lys?Arg?Asn?Arg?Glu?Leu?Asp?Tyr?Gly?Ile?Arg?Leu?His?Val

225 230 235 240

Ile?Ala?Arg?Pro?Thr?Glu?Asp?Glu?Ala?Trp?Ser?Val?Ala?Gln?Asn?Leu

245 25 255

Leu?Asp?Gln?Leu?Asp?Gln?Glu?Glu?Val?Ala?Arg?Ile?Gln?Glu?Gly?Leu

260 265 270

Ala?Arg?Ser?Gln?Ser?Glu?Gly?Gln?Arg?Arg?Met?Thr?Glu?Leu?His?Gly

275 280 285

Gln?Gly?Ala?Ala?Phe?Thr?Ala?Gly?Ala?Asp?Ala?Arg?Ser?Leu?Glu?Ile

290 295 300

Ala?Pro?Asn?Leu?Trp?Ala?Gly?Val?Gly?Leu?Val?Arg?Gly?Gly?Ala?Gly

305 310 315 320

Thr?Ala?Leu?Val?Gly?Ser?Tyr?Glu?Gln?Val?Ala?Gln?Ala?Ile?Leu?Arg

325 330 335

Tyr?Arg?Asp?Ile?Gly?Leu?Ser?His?Phe?Ile?Phe?Ser?Gly?Tyr?Pro?His

340 345 350

Leu?Glu?Glu?Thr?Tyr?His?Val?Gly?Glu?Gly?Val?Val?Pro?Glu?Leu?Leu

355 360 365

Lys?Leu?Gly?Val?Pro?Val?Asn?Asn?His?Glu?Glu?Gln?Arg?Asn?Asp?Val

370 375 380

Val?Ala?Thr?Pro?Phe?Ile?Ser?Arg

385 390

<210>349

<211>681

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(673)

<223>RXA01192

<400>349

ccacggtgaa?cacctgcagg?tggagcaagc?tagccttgcg?catccgccag?agattattcc?60

ggagattctt?tttggtggat?cgtcgccagc?tgcaggtgag?gtg?gct?gca?cgt?tat 115

Val?Ala?Ala?Arg?Tyr

1 5

gcg?gac?acc?tat?ctc?acg?tgg?ggt?gaa?act?ccc?gat?cag?gtg?gcg?cag 163

Ala?Asp?Thr?Tyr?Leu?Thr?Trp?Gly?Glu?Thr?Pro?Asp?Gln?Val?Ala?Gln

10 15 20

aaa?atc?aac?tgg?atc?aac?gag?cta?gca?gca?cag?cgc?ggc?cgg?gaa?ctg 211

Lys?Ile?Asn?Trp?Ile?Asn?Glu?Leu?Ala?Ala?Gln?Arg?Gly?Arg?Glu?Leu

25 30 35

cgc?cat?gga?atc?cgc?ttc?cat?gtg?atc?acc?cgc?gat?acg?tct?gaa?gaa 259

Arg?His?Gly?Ile?Arg?Phe?His?Val?Ile?Thr?Arg?Asp?Thr?Ser?Glu?Glu

40 45 50

gca?tgg?gtg?gtg?gca?gag?aag?ttg?att?agc?ggg?gtc?act?cca?gaa?cag 307

Ala?Trp?Val?Val?Ala?Glu?Lys?Leu?Ile?Ser?Gly?Val?Thr?Pro?Glu?Gln

55 60 65

gtc?gct?aag?gct?caa?gcc?ggg?ttt?gca?acg?tct?aag?tcg?gag?ggg?cag 355

Val?Ala?Lys?Ala?Gln?Ala?Gly?Phe?Ala?Thr?Ser?Lys?Ser?Glu?Gly?Gln

70 75 80 85

cgc?cgg?atg?gct?gag?ctg?cac?agc?aag?ggt?cgt?gcc?ttt?act?agt?ggc 403

Arg?Arg?Met?Ala?Glu?Leu?His?Ser?Lys?Gly?Arg?Ala?Phe?Thr?Ser?Gly

90 95 100

tca?act?gct?cgt?gat?ctg?gag?gtg?tat?ccc?aat?gtg?tgg?gca?ggc?gtc 451

Ser?Thr?Ala?Arg?Asp?Leu?Glu?Val?Tyr?Pro?Asn?Val?Trp?Ala?Gly?Val

105 110 115

ggt?ttg?ctt?cgc?gga?ggt?gca?gga?aca?gcc?ctt?gtg?ggc?tcg?cat?gaa 499

Gly?Leu?Leu?Arg?Gly?Gly?Ala?Gly?Thr?Ala?Leu?Val?Gly?Ser?His?Glu

120 125 130

gag?gtc?gcc?gat?cgc?atc?gaa?gaa?tac?gca?gca?ctc?ggc?ttg?gat?cag 547

Glu?Val?Ala?Asp?Arg?Ile?Glu?Glu?Tyr?Ala?Ala?Leu?Gly?Leu?Asp?Gln

135 140 145

ttt?gta?ctg?tcg?ggt?tat?cca?aac?ttg?gag?gag?gcc?ttc?cac?ttc?ggt 595

Phe?Val?Leu?Ser?Gly?Tyr?Pro?Asn?Leu?Glu?Glu?Ala?Phe?His?Phe?Gly

150 155 160 165

gag?ggt?gtg?att?ccg?aaa?ctg?ctg?cgc?cgc?ggt?gtg?gat?atc?aaa?aat 643

Glu?Gly?Val?Ile?Pro?Lys?Leu?Leu?Arg?Arg?Gly?Val?Asp?Ile?Lys?Asn

170 175 180

caa?gaa?tca?cga?gtt?ttg?gaa?cct?gtt?ggg?taaacggg 681

Gln?Glu?Ser?Arg?Val?Leu?Glu?Pro?Val?Gly

185 190

<210>350

<211>191

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>350

Val?Ala?Ala?Arg?Tyr?Ala?Asp?Thr?Tyr?Leu?Thr?Trp?Gly?Glu?Thr?Pro

1 5 10 15

Asp?Gln?Val?Ala?Gln?Lys?Ile?Asn?Trp?Ile?Asn?Glu?Leu?Ala?Ala?Gln

20 25 30

Arg?Gly?Arg?Glu?Leu?Arg?His?Gly?Ile?Arg?Phe?His?Val?Ile?Thr?Arg

35 40 45

Asp?Thr?Ser?Glu?Glu?Ala?Trp?Val?Val?Ala?Glu?Lys?Leu?Ile?Ser?Gly

50 55 60

Val?Thr?Pro?Glu?Gln?Val?Ala?Lys?Ala?Gln?Ala?Gly?Phe?Ala?Thr?Ser

65 70 75 80

Lys?Ser?Glu?Gly?Gln?Arg?Arg?Met?Ala?Glu?Leu?His?Ser?Lys?Gly?Arg

85 90 95

Ala?Phe?Thr?Ser?Gly?Ser?Thr?Ala?Arg?Asp?Leu?Glu?Val?Tyr?Pro?Asn

100 105 110

Val?Trp?Ala?Gly?Val?Gly?Leu?Leu?Arg?Gly?Gly?Ala?Gly?Thr?Ala?Leu

115 120 125

Val?Gly?Ser?His?Glu?Glu?Val?Ala?Asp?Arg?Ile?Glu?Glu?Tyr?Ala?Ala

130 135 140

Leu?Gly?Leu?Asp?Gln?Phe?Val?Leu?Ser?Gly?Tyr?Pro?Asn?Leu?Glu?Glu

145 150 155 160

Ala?Phe?His?Phe?Gly?Glu?Gly?Val?Ile?Pro?Lys?Leu?Leu?Arg?Arg?Gly

165 170 175

Val?Asp?Ile?Lys?Asn?Gln?Glu?Ser?Arg?Val?Leu?Glu?Pro?Val?Gly

180 185 190

<210>351

<211>918

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(895)

<223>RXA00715

<400>351

gtggtgttaa?gcactaagat?ggcaggttat?gacttctctt?aaagtaactt?cgtccgcaga?60

tgcaaccaat?aacaatgatg?cccattttcc?tgaaggtcca?gtg?gta?acc?gtt?gac 115

Val?Val?Thr?Val?Asp

1 5

tgg?ttg?tca?cac?aac?ctt?gac?cgg?gat?gat?gtc?atc?gtg?ttg?tgt?gcc 163

Trp?Leu?Ser?His?Asn?Leu?Asp?Arg?Asp?Asp?Val?Ile?Val?Leu?Cys?Ala

10 15 20

aca?atg?gag?gat?gat?gaa?att?gca?cgt?caa?gcg?gga?att?ccg?ggg?gca 211

Thr?Met?Glu?Asp?Asp?Glu?Ile?Ala?Arg?Gln?Ala?Gly?Ile?Pro?Gly?Ala

25 30 35

ttt?ctc?gct?gac?ttg?gaa?gga?gat?ttc?tca?gat?cca?cat?tcc?gag?ctt 259

Phe?Leu?Ala?Asp?Leu?Glu?Gly?Asp?Phe?Ser?Asp?Pro?His?Ser?Glu?Leu

40 45 50

cca?cac?acc?gcg?cca?cca?aat?ttg?gtg?ggt?ttg?cta?gaa?agc?tac?ggc 307

Pro?His?Thr?Ala?Pro?Pro?Asn?Leu?Val?Gly?Leu?Leu?Glu?Ser?Tyr?Gly

55 60 65

att?agc?acc?gat?tcc?acg?gtg?gtt?gtt?tat?gat?ctg?cac?ggc?ctc?atg 355

Ile?Ser?Thr?Asp?Ser?Thr?Val?Val?Val?Tyr?Asp?Leu?His?Gly?Leu?Met

70 75 80 85

gtt?gca?ccg?cgg?gtg?tgg?tgg?ctt?ctc?cgt?gtt?gct?gga?tta?agc?agc 403

Val?Ala?Pro?Arg?Val?Trp?Trp?Leu?Leu?Arg?Val?Ala?Gly?Leu?Ser?Ser

90 95 100

att?ggc?gtg?ctt?gat?ggc?gga?ttg?cca?gcc?tgg?gtt?gat?gct?ggc?ctt 451

Ile?Gly?Val?Leu?Asp?Gly?Gly?Leu?Pro?Ala?Trp?Val?Asp?Ala?Gly?Leu

105 110 115

cca?acg?gaa?ccg?ctg?tcg?cta?cct?aca?agt?ggt?gga?agg?atc?agc?gca 499

Pro?Thr?Glu?Pro?Leu?Ser?Leu?Pro?Thr?Ser?Gly?Gly?Arg?Ile?Ser?Ala

120 125 130

gaa?cca?cag?cca?gat?tta?ctc?gtt?ggt?gcc?tcc?ggc?gtt?gaa?cgg?gcg 547

Glu?Pro?Gln?Pro?Asp?Leu?Leu?Val?Gly?Ala?Ser?Gly?Val?Glu?Arg?Ala

135 140 145

atc?gcg?cgc?tca?agc?aag?gca?gtg?att?gat?gct?cgt?aat?gcg?agc?cga 595

Ile?Ala?Arg?Ser?Ser?Lys?Ala?Val?Ile?Asp?Ala?Arg?Asn?Ala?Ser?Arg

150 155 160 165

ttc?gct?ggc?gtt?gaa?gaa?gag?ccc?cgt?cca?ggc?ctt?cga?aaa?ggg?tcg 643

Phe?Ala?Gly?Val?Glu?Glu?Glu?Pro?Arg?Pro?Gly?Leu?Arg?Lys?Gly?Ser

170 175 180

atc?cct?gga?agc?gtc?aac?att?ccc?ttc?act?gac?att?tct?gat?gag?cat 691

Ile?Pro?Gly?Ser?Val?Asn?Ile?Pro?Phe?Thr?Asp?Ile?Ser?Asp?Glu?His

185 190 195

ggt?ttt?gtc?cgg?cca?gca?gaa?gaa?ctg?aag?gaa?ttg?atc?ttc?agc?cgc 739

Gly?Phe?Val?Arg?Pro?Ala?Glu?Glu?Leu?Lys?Glu?Leu?Ile?Phe?Ser?Arg

200 205 210

aca?aat?gga?gcg?cag?tcg?ttg?gtc?ttt?agc?tgt?ggc?tcc?gga?gtc?acg 787

Thr?Asn?Gly?Ala?Gln?Ser?Leu?Val?Phe?Ser?Cys?Gly?Ser?Gly?Val?Thr

215 220 225

gca?tgt?gtt?gat?gcc?tac?gct?gca?gtt?atc?gca?ggt?tat?gac?gac?gtt 835

Ala?Cys?Val?Asp?Ala?Tyr?Ala?Ala?Val?Ile?Ala?Gly?Tyr?Asp?Asp?Val

230 235 240 245

gta?gtg?tat?gaa?ggc?tct?tgg?gcg?gag?tgg?ggc?aac?ccg?gca?aac?caa 883

Val?Val?Tyr?Glu?Gly?Ser?Trp?Ala?Glu?Trp?Gly?Asn?Pro?Ala?Asn?Gln

250 255 260

aag?ccg?att?gct?taacgcccgc?tatgataacc?act 918

Lys?Pro?Ile?Ala

265

<210>352

<211>265

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>352

Val?Val?Thr?Val?Asp?Trp?Leu?Ser?His?Asn?Leu?Asp?Arg?Asp?Asp?Val

1 5 10 15

Ile?Val?Leu?Cys?Ala?Thr?Met?Glu?Asp?Asp?Glu?Ile?Ala?Arg?Gln?Ala

20 25 30

Gly?Ile?Pro?Gly?Ala?Phe?Leu?Ala?Asp?Leu?Glu?Gly?Asp?Phe?Ser?Asp

35 40 45

Pro?His?Ser?Glu?Leu?Pro?His?Thr?Ala?Pro?Pro?Asn?Leu?Val?Gly?Leu

50 55 60

Leu?Glu?Ser?Tyr?Gly?Ile?Ser?Thr?Asp?Ser?Thr?Val?Val?Val?Tyr?Asp

65 70 75 80

Leu?His?Gly?Leu?Met?Val?Ala?Pro?Arg?Val?Trp?Trp?Leu?Leu?Arg?Val

85 90 95

Ala?Gly?Leu?Ser?Ser?Ile?Gly?Val?Leu?Asp?Gly?Gly?Leu?Pro?Ala?Trp

100 105 110

Val?Asp?Ala?Gly?Leu?Pro?Thr?Glu?Pro?Leu?Ser?Leu?Pro?Thr?Ser?Gly

115 120 125

Gly?Arg?Ile?Ser?Ala?Glu?Pro?Gln?Pro?Asp?Leu?Leu?Val?Gly?Ala?Ser

130 135 140

Gly?Val?Glu?Arg?Ala?Ile?Ala?Arg?Ser?Ser?Lys?Ala?Val?Ile?Asp?Ala

145 150 155 160

Arg?Asn?Ala?Ser?Arg?Phe?Ala?Gly?Val?Glu?Glu?Glu?Pro?Arg?Pro?Gly

165 170 175

Leu?Arg?Lys?Gly?Ser?Ile?Pro?Gly?Ser?Val?Asn?Ile?Pro?Phe?Thr?Asp

180 185 190

Ile?Ser?Asp?Glu?His?Gly?Phe?Val?Arg?Pro?Ala?Glu?Glu?Leu?Lys?Glu

195 200 205

Leu?Ile?Phe?Ser?Arg?Thr?Asn?Gly?Ala?Gln?Ser?Leu?Val?Phe?Ser?Cys

210 215 220

Gly?Ser?Gly?Val?Thr?Ala?Cys?Val?Asp?Ala?Tyr?Ala?Ala?Val?Ile?Ala

225 230 235 240

Gly?Tyr?Asp?Asp?Val?Val?Val?Tyr?Glu?Gly?Ser?Trp?Ala?Glu?Trp?Gly

245 250 255

Asn?Pro?Ala?Asn?Gln?Lys?Pro?Ile?Ala

260 265

<210>353

<211>945

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(922)

<223>RXA01664

<400>353

cgggttacca?aagtgaatgg?taggggaagt?ttccgtgtct?tataccggtt?aggttttgcc?60

cgcgctgcgc?ttggtcacat?taacgcctag?gctcggggct?atg?acc?gtg?ttg?att 115

Met?Thr?Val?Leu?Ile

1 5

tct?ccg?tcc?acc?ctt?gct?gaa?tca?atc?cac?gct?ggt?aag?aaa?caa?act 163

Ser?Pro?Ser?Thr?Leu?Ala?Glu?Ser?Ile?His?Ala?Gly?Lys?Lys?Gln?Thr

10 15 20

gtt?ctc?gct?gct?ttc?tgg?gct?cca?att?gaa?gga?gca?ggc?cgc?aca?gtt 211

Val?Leu?Ala?Ala?Phe?Trp?Ala?Pro?Ile?Glu?Gly?Ala?Gly?Arg?Thr?Val

25 30 35

ttc?tgc?tct?gag?cac?atc?cca?act?tcc?att?ttc?tgc?gac?cct?gcc?ctt 259

Phe?Cys?Ser?Glu?His?Ile?Pro?Thr?Ser?Ile?Phe?Cys?Asp?Pro?Ala?Leu

40 45 50

gag?ctt?tcc?gga?gtt?cct?tcc?tct?gaa?gat?ggc?cgc?aac?cca?ctg?cca 307

Glu?Leu?Ser?Gly?Val?Pro?Ser?Ser?Glu?Asp?Gly?Arg?Asn?Pro?Leu?Pro

55 60 65

ccg?ctg?aat?gtg?ttg?gca?cgt?tct?ttc?agg?acc?tgg?ggt?ttg?aat?acc 355

Pro?Leu?Asn?Val?Leu?Ala?Arg?Ser?Phe?Arg?Thr?Trp?Gly?Leu?Asn?Thr

70 75 80 85

gat?cgt?gaa?atc?gtg?ttt?tac?gat?cag?gga?cgt?ggc?ctt?ttt?gct?gca 403

Asp?Arg?Glu?Ile?Val?Phe?Tyr?Asp?Gln?Gly?Arg?Gly?Leu?Phe?Ala?Ala

90 95 100

cgc?gcc?tgg?tgg?atc?ctc?cga?tgg?gcg?ggc?atg?ccc?aac?gtt?cgc?atc 451

Arg?Ala?Trp?Trp?Ile?Leu?Arg?Trp?Ala?Gly?Met?Pro?Asn?Val?Arg?Ile

105 110 115

ctt?gac?ggt?ggt?ttc?cag?aag?tgg?gaa?gac?cat?gag?ctg?gga?cac?gct 499

Leu?Asp?Gly?Gly?Phe?Gln?Lys?Trp?Glu?Asp?His?Glu?Leu?Gly?His?Ala

120 125 130

ggc?ggg?cct?gga?aac?ttc?ccg?cac?ttt?tgc?aat?gtg?cgt?ccc?aac?cca 547

Gly?Gly?Pro?Gly?Asn?Phe?Pro?His?Phe?Cys?Asn?Val?Arg?Pro?Asn?Pro

135 140 145

ggt?cag?ctg?tcg?gta?gcg?acc?atc?gaa?gat?gtc?aag?gca?cat?cag?ggc 595

Gly?Gln?Leu?Ser?Val?Ala?Thr?Ile?Glu?Asp?Val?Lys?Ala?His?Gln?Gly

150 155 160 165

att?ttg?att?gat?tct?cgc?gat?gaa?caa?cga?ttt?gcg?ggt?cgc?agt?gaa 643

Ile?Leu?Ile?Asp?Ser?Arg?Asp?Glu?Gln?Arg?Phe?Ala?Gly?Arg?Ser?Glu

170 175 180

aag?ctc?gat?ctg?aaa?gcc?gga?cac?att?cca?ggc?gct?atc?aac?atc?aac 691

Lys?Leu?Asp?Leu?Lys?Ala?Gly?His?Ile?Pro?Gly?Ala?Ile?Asn?Ile?Asn

185 190 195

gct?aaa?tct?ttg?ctg?gaa?gat?gat?ttc?acc?ttc?aaa?tca?cca?gaa?gaa 739

Ala?Lys?Ser?Leu?Leu?Glu?Asp?Asp?Phe?Thr?Phe?Lys?Ser?Pro?Glu?Glu

200 205 210

atc?cgc?cag?att?ttt?gcg?gac?aag?ggg?gta?acc?agc?gga?gag?aac?gtc 787

Ile?Arg?Gln?Ile?Phe?Ala?Asp?Lys?Gly?Val?Thr?Ser?Gly?Glu?Asn?Val

215 220 225

atc?gtt?tat?tcc?ggt?tcc?ggt?aac?cac?tcg?tcc?cag?ttg?ctg?gct?ggc 835

Ile?Val?Tyr?Ser?Gly?Ser?Gly?Asn?His?Ser?Ser?Gln?Leu?Leu?Ala?Gly

230 235 240 245

atg?gag?cac?gcg?ggg?cta?acc?ggt?gcg?agc?cat?tat?ttt?gct?ggt?tgg 883

Met?Glu?His?Ala?Gly?Leu?Thr?Gly?Ala?Ser?His?Tyr?Phe?Ala?Gly?Trp

250 255 260

tca?cag?tgg?agc?gct?aac?ccc?gag?aat?cct?atc?gag?gcc?taaaatcgtg 932

Ser?Gln?Trp?Ser?Ala?Asn?Pro?Glu?Asn?Pro?Ile?Glu?Ala

265 270

gcttgagtac?gca 945

<210>354

<211>274

<2l2>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>354

Met?Thr?Val?Leu?Ile?Ser?Pro?Ser?Thr?Leu?Ala?Glu?Ser?Ile?His?Ala

1 5 10 15

Gly?Lys?Lys?Gln?Thr?Val?Leu?Ala?Ala?Phe?Trp?Ala?Pro?Ile?Glu?Gly

20 25 30

Ala?Gly?Arg?Thr?Val?Phe?Cys?Ser?Glu?His?Ile?Pro?Thr?Ser?Ile?Phe

35 40 45

Cys?Asp?Pro?Ala?Leu?Glu?Leu?Ser?Gly?Val?Pro?Ser?Ser?Glu?Asp?Gly

50 55 60

Arg?Asn?Pro?Leu?Pro?Pro?Leu?Asn?Val?Leu?Ala?Arg?Ser?Phe?Arg?Thr

65 70 75 80

Trp?Gly?Leu?Asn?Thr?Asp?Arg?Glu?Ile?Val?Phe?Tyr?Asp?Gln?Gly?Arg

85 90 95

Gly?Leu?Phe?Ala?Ala?Arg?Ala?Trp?Trp?Ile?Leu?Arg?Trp?Ala?Gly?Met

100 105 110

Pro?Asn?Val?Arg?Ile?Leu?Asp?Gly?Gly?Phe?Gln?Lys?Trp?Glu?Asp?His

115 120 125

Glu?Leu?Gly?His?Ala?Gly?Gly?Pro?Gly?Asn?Phe?Pro?His?Phe?Cys?Asn

130 135 140

Val?Arg?Pro?Asn?Pro?Gly?Gln?Leu?Ser?Val?Ala?Thr?Ile?Glu?Asp?Val

145 150 155 160

Lys?Ala?His?Gln?Gly?Ile?Leu?Ile?Asp?Ser?Arg?Asp?Glu?Gln?Arg?Phe

165 170 175

Ala?Gly?Arg?Ser?Glu?Lys?Leu?Asp?Leu?Lys?Ala?Gly?His?Ile?Pro?Gly

180 185 190

Ala?Ile?Asn?Ile?Asn?Ala?Lys?Ser?Leu?Leu?Glu?Asp?Asp?Phe?Thr?Phe

195 200 205

Lys?Ser?Pro?Glu?Glu?Ile?Arg?Gln?Ile?Phe?Ala?Asp?Lys?Gly?Val?Thr

210 215 220

Ser?Gly?Glu?Asn?Val?Ile?Val?Tyr?Ser?Gly?Ser?Gly?Asn?His?Ser?Ser

225 230 235 240

Gln?Leu?Leu?Ala?Gly?Met?Glu?His?Ala?Gly?Leu?Thr?Gly?Ala?Ser?His

245 250 255

Tyr?Phe?Ala?Gly?Trp?Ser?Gln?Trp?Ser?Ala?Asn?Pro?Glu?Asn?Pro?Ile

260 265 270

Glu?Ala

<210>355

<211>746

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(723)

<223>RXN02334

<400>355

gtc?aaa?gac?ctc?aac?gat?ccc?ctc?acc?cgc?gat?ttc?att?gac?ggt?gaa 48

Val?Lys?Asp?Leu?Asn?Asp?Pro?Leu?Thr?Arg?Asp?Phe?Ile?Asp?Gly?Glu

1 5 10 15

gct?ttc?gct?gag?ctg?atg?aac?cgc?aag?ggc?atc?gct?cgc?gat?gac?acc 96

Ala?Phe?Ala?Glu?Leu?Met?Asn?Arg?Lys?Gly?Ile?Ala?Arg?Asp?Asp?Thr

20 25 30

gtt?gtt?gtc?tac?ggt?gac?aag?tcc?aac?tgg?tgg?gct?gcg?ttc?acc?ctg 144

Val?Val?Val?Tyr?Gly?Asp?Lys?Ser?Asn?Trp?Trp?Ala?Ala?Phe?Thr?Leu

35 40 45

tgg?gtc?ttc?gaa?ctg?ttc?ggc?cac?tcc?gat?gtc?cgc?ctg?ctc?aac?ggc 192

Trp?Val?Phe?Glu?Leu?Phe?Gly?His?Ser?Asp?Val?Arg?Leu?Leu?Asn?Gly

50 55 60

ggc?cgc?gac?gcg?tgg?atg?gct?gaa?gag?cgc?gac?acc?tcc?tac?gtg?gtt 240

Gly?Arg?Asp?Ala?Trp?Met?Ala?Glu?Glu?Arg?Asp?Thr?Ser?Tyr?Val?Val

65 70 75 80

ccg?gag?tac?ccc?tcc?gcc?aac?tac?ccc?gtc?gtg?gag?cgt?gtc?gac?gaa 288

Pro?Glu?Tyr?Pro?Ser?Ala?Asn?Tyr?Pro?Val?Val?Glu?Arg?Val?Asp?Glu

85 90 95

aac?cag?cgc?gcg?ttc?gtg?gct?gag?gtg?ctc?ggt?tcg?ctc?acg?caa?tcc 336

Asn?Gln?Arg?Ala?Phe?Val?Ala?Glu?Val?Leu?Gly?Ser?Leu?Thr?Gln?Ser

100 105 110

ggt?ggc?atg?acg?ctt?gtc?gac?gtc?agg?acc?cct?tcg?gag?ttc?tcc?gga 384

Gly?Gly?Met?Thr?Leu?Val?Asp?Val?Arg?Thr?Pro?Ser?Glu?Phe?Ser?Gly

115 120 125

ttg?gat?gag?cac?ggc?aac?cca?acc?tca?aac?acc?ggc?gtg?ctt?cgt?ggt 432

Leu?Asp?Glu?His?Gly?Asn?Pro?Thr?Ser?Asn?Thr?Gly?Val?Leu?Arg?Gly

130 135 140

gga?cac?atc?cca?ggc?gcg?atc?aac?ctg?gat?tgg?tcg?gac?gct?gtt?ctt 480

Gly?His?Ile?Pro?Gly?Ala?Ile?Asn?Leu?Asp?Trp?Ser?Asp?Ala?Val?Leu

145 150 155 160

ccc?aac?gga?aac?ttc?cgc?acc?cgt?gca?gag?ttg?gac?aag?ctc?tac?gcc 528

Pro?Asn?Gly?Asn?Phe?Arg?Thr?Arg?Ala?Glu?Leu?Asp?Lys?Leu?Tyr?Ala

165 170 175

gat?ctc?aac?cca?gct?gac?gat?acc?gtt?gtc?tac?tgc?cag?gtt?ggc?gac 576

Asp?Leu?Asn?Pro?Ala?Asp?Asp?Thr?Val?Val?Tyr?Cys?Gln?Val?Gly?Asp

180 185 190

cgc?gcg?gcc?cac?acc?tgg?ttc?gtg?ctg?aag?tat?ctg?ctc?ggt?ttc?aac 624

Arg?Ala?Ala?His?Thr?Trp?Phe?Val?Leu?Lys?Tyr?Leu?Leu?Gly?Phe?Asn

195 200 205

aac?gtc?cga?aac?tat?gac?gga?tcg?tgg?gca?gaa?tgg?ggc?aat?atg?gtt 672

Asn?Val?Arg?Asn?Tyr?Asp?Gly?Ser?Trp?Ala?Glu?Trp?Gly?Asn?Met?Val

210 215 220

cgc?atg?ccg?atc?gaa?act?ggc?gaa?aac?acc?aaa?aat?aac?gtt?tcg?gtg 720

Arg?Met?Pro?Ile?Glu?Thr?Gly?Glu?Asn?Thr?Lys?Asn?Asn?Val?Ser?Val

225 230 235 240

tca?tagaataggc?gtatcccctt?ttt 746

Ser

<210>356

<211>241

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>356

Val?Lys?Asp?Leu?Asn?Asp?Pro?Leu?Thr?Arg?Asp?Phe?Ile?Asp?Gly?Glu

1 5 10 15

Ala?Phe?Ala?Glu?Leu?Met?Asn?Arg?Lys?Gly?Ile?Ala?Arg?Asp?Asp?Thr

20 25 30

Val?Val?Val?Tyr?Gly?Asp?Lys?Ser?Asn?Trp?Trp?Ala?Ala?Phe?Thr?Leu

35 40 45

Trp?Val?Phe?Glu?Leu?Phe?Gly?His?Ser?Asp?Val?Arg?Leu?Leu?Asn?Gly

50 55 60

Gly?Arg?Asp?Ala?Trp?Met?Ala?Glu?Glu?Arg?Asp?Thr?Ser?Tyr?Val?Val

65 70 75 80

Pro?Glu?Tyr?Pro?Ser?Ala?Asn?Tyr?Pro?Val?Val?Glu?Arg?Val?Asp?Glu

85 90 95

Asn?Gln?Arg?Ala?Phe?Val?Ala?Glu?Val?Leu?Gly?Ser?Leu?Thr?Gln?Ser

100 105 110

Gly?Gly?Met?Thr?Leu?Val?Asp?Val?Arg?Thr?Pro?Ser?Glu?Phe?Ser?Gly

115 120 125

Leu?Asp?Glu?His?Gly?Asn?Pro?Thr?Ser?Asn?Thr?Gly?Val?Leu?Arg?Gly

130 135 140

Gly?His?Ile?Pro?Gly?Ala?Ile?Asn?Leu?Asp?Trp?Ser?Asp?Ala?Val?Leu

145 150 155 160

Pro?Asn?Gly?Asn?Phe?Arg?Thr?Arg?Ala?Glu?Leu?Asp?Lys?Leu?Tyr?Ala

165 170 175

Asp?Leu?Asn?Pro?Ala?Asp?Asp?Thr?Val?Val?Tyr?Cys?Gln?Val?Gly?Asp

180 185 190

Arg?Ala?Ala?His?Thr?Trp?Phe?Val?Leu?Lys?Tyr?Leu?Leu?Gly?Phe?Asn

195 200 205

Asn?Val?Arg?Asn?Tyr?Asp?Gly?Ser?Trp?Ala?Glu?Trp?Gly?Asn?Met?Val

210 215 220

Arg?Met?Pro?Ile?Glu?Thr?Gly?Glu?Asn?Thr?Lys?Asn?Asn?Val?Ser?Val

225 230 235 240

Ser

<210>357

<211>377

<2l2>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(354)

<223>FRXA02334

<400>357

gga?gtt?ctc?ccg?gat?tgg?atg?agc?acg?gca?acc?caa?ccc?tca?aac?acc 48

Gly?Val?Leu?Pro?Asp?Trp?Met?Ser?Thr?Ala?Thr?Gln?Pro?Ser?Asn?Thr

1 5 10 15

ggc?gtg?ctt?cgt?ggt?gaa?cac?atc?cca?ggc?gcg?atc?aac?ctg?gat?tgg 96

Gly?Val?Leu?Arg?Gly?Glu?His?Ile?Pro?Gly?Ala?Ile?Asn?Leu?Asp?Trp

20 25 30

tcg?gac?gct?gtt?ctt?ccc?aac?gga?aac?ttc?cgc?acc?cgt?gca?gag?ttg 144

Ser?Asp?Ala?Val?Leu?Pro?Asn?Gly?Asn?Phe?Arg?Thr?Arg?Ala?Glu?Leu

35 40 45

gac?aag?ctc?tac?gcc?gat?ctc?aac?cca?gct?gac?gat?acc?gtt?gtc?tac 192

Asp?Lys?Leu?Tyr?Ala?Asp?Leu?Asn?Pro?Ala?Asp?Asp?Thr?Val?Val?Tyr

50 55 60

tgc?cag?gtt?ggc?gac?cgc?gcg?gcc?cac?acc?tgg?ttc?gtg?ctg?aag?tat 240

Cys?Gln?Val?Gly?Asp?Arg?Ala?Ala?His?Thr?Trp?Phe?Val?Leu?Lys?Tyr

65 70 75 80

ctg?ctc?ggt?ttc?aac?aac?gtc?cga?aac?tat?gac?gga?tcg?tgg?gca?gaa 288

Leu?Leu?Gly?Phe?Asn?Asn?Val?Arg?Asn?Tyr?Asp?Gly?Ser?Trp?Ala?Glu

85 90 95

tgg?ggc?aat?atg?gtt?cgc?atg?ccg?atc?gaa?act?ggc?gaa?aac?acc?aaa 336

Trp?Gly?Asn?Met?Val?Arg?Met?Pro?Ile?Glu?Thr?Gly?Glu?Asn?Thr?Lys

100 105 110

aat?aac?gtt?tcg?gtg?tca?tagaataggc?gtatcccctt?ttt 377

Asn?Asn?Val?Ser?Val?Ser

115

<210>358

<211>118

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>358

Gly?Val?Leu?Pro?Asp?Trp?Met?Ser?Thr?Ala?Thr?Gln?Pro?Ser?Asn?Thr

1 5 10 15

Gly?Val?Leu?Arg?Gly?Glu?His?Ile?Pro?Gly?Ala?Ile?Asn?Leu?Asp?Trp

20 25 30

Ser?Asp?Ala?Val?Leu?Pro?Asn?Gly?Asn?Phe?Arg?Thr?Arg?Ala?Glu?Leu

35 40 45

Asp?Lys?Leu?Tyr?Ala?Asp?Leu?Asn?Pro?Ala?Asp?Asp?Thr?Val?Val?Tyr

50 55 60

Cys?Gln?Val?Gly?Asp?Arg?Ala?Ala?His?Thr?Trp?Phe?Val?Leu?Lys?Tyr

65 70 75 80

Leu?Leu?Gly?Phe?Asn?Asn?Val?Arg?Asn?Tyr?Asp?Gly?Ser?Trp?Ala?Glu

85 90 95

Trp?Gly?Asn?Met?Val?Arg?Met?Pro?Ile?Glu?Thr?Gly?Glu?Asn?Thr?Lys

100 105 110

Asn?Asn?Val?Ser?Val?Ser

115

<210>359

<21l>3945

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(3922)

<223>RXN01499

<400>359

gcagcaatta?tctccaccga?agaggactaa?atataacgtg?gcattgagca?gtgttccagc?60

acagttcctg?agatccgccc?aggcgccccc?gaagcgtact?ttg?tgg?gac?gtc?tta 115

Leu?Trp?Asp?Val?Leu

1 5

gaa?tcc?gtc?gcc?tct?act?tat?cct?gag?gca?gca?gct?att?gac?gat?ggc 163

Glu?Ser?Val?Ala?Ser?Thr?Tyr?Pro?Glu?Ala?Ala?Ala?Ile?Asp?Asp?Gly

10 15 20

cag?gtg?ttg?acc?tac?gca?gag?ttg?atg?gaa?gaa?gtc?acc?gcg?ttg?gct 211

Gln?Val?Leu?Thr?Tyr?Ala?Glu?Leu?Met?Glu?Glu?Val?Thr?Ala?Leu?Ala

25 30 35

gat?tcc?att?cat?gca?cag?ggc?att?cgc?cgt?ggt?gat?cgc?atc?ggt?att 259

Asp?Ser?Ile?His?Ala?Gln?Gly?Ile?Arg?Arg?Gly?Asp?Arg?Ile?Gly?Ile

40 45 50

cgc?atg?ccg?tct?ggt?acg?cgt?gac?ctt?tac?atc?gct?att?ttg?gcc?act 307

Arg?Met?Pro?Ser?Gly?Thr?Arg?Asp?Leu?Tyr?Ile?Ala?Ile?Leu?Ala?Thr

55 60 65

ctc?gct?gct?ggt?gct?gct?tac?gtg?cca?gtt?gat?gca?gat?gat?cct?gaa 355

Leu?Ala?Ala?Gly?Ala?Ala?Tyr?Val?Pro?Val?Asp?Ala?Asp?Asp?Pro?Glu

70 75 80 85

gag?cgc?gcc?gag?atg?gtg?ttt?ggt?gaa?gca?aat?att?aat?gcg?ctt?ttc 403

Glu?Arg?Ala?Glu?Met?Val?Phe?Gly?Glu?Ala?Asn?Ile?Asn?Ala?Leu?Phe

90 95 100

gac?gcc?acc?ggc?ttc?cat?atg?ctt?cgc?ccg?acc?gcg?ggc?ggc?gat?acc 451

Asp?Ala?Thr?Gly?Phe?His?Met?Leu?Arg?Pro?Thr?Ala?Gly?Gly?Asp?Thr

105 110 115

cgt?aga?cca?cgc?ttg?gat?gat?acg?gcg?tgg?att?atc?ttt?act?tcc?ggt 499

Arg?Arg?Pro?Arg?Leu?Asp?Asp?Thr?Ala?Trp?Ile?Ile?Phe?Thr?Ser?Gly

120 125 130

tcc?acc?ggc?aag?cct?aag?ggt?gtg?gct?gtg?tcc?cac?cgt?tca?gct?gcg 547

Ser?Thr?Gly?Lys?Pro?Lys?Gly?Val?Ala?Val?Ser?His?Arg?Ser?Ala?Ala

135 140 145

gct?ttc?gtg?gat?gcc?gaa?gca?caa?atg?ttc?ctt?gtc?gat?cac?cct?tcc 595

Ala?Phe?Val?Asp?Ala?Glu?Ala?Gln?Met?Phe?Leu?Val?Asp?His?Pro?Ser

150 155 160 165

ggc?ccc?ctt?ggc?cca?gaa?gac?cga?gtc?ctt?gcg?gga?ttg?tct?gta?gcc 643

Gly?Pro?Leu?Gly?Pro?Glu?Asp?Arg?Val?Leu?Ala?Gly?Leu?Ser?Val?Ala

170 175 180

ttt?gac?gca?tct?tgt?gag?gaa?atg?tgg?ttg?gcc?tgg?ggc?cac?ggc?gcc 691

Phe?Asp?Ala?Ser?Cys?Glu?Glu?Met?Trp?Leu?Ala?Trp?Gly?His?Gly?Ala

185 190 195

tgc?ttg?gtg?cca?gca?cca?cgc?tcc?cta?gtc?cgt?tcc?ggt?atg?gac?ttg 739

Cys?Leu?Val?Pro?Ala?Pro?Arg?Ser?Leu?Val?Arg?Ser?Gly?Met?Asp?Leu

200 205 210

ggc?cca?tgg?ctg?att?cgc?cgc?gac?atc?agt?gtc?gtc?tcc?acc?gtc?cca 787

Gly?Pro?Trp?Leu?Ile?Arg?Arg?Asp?Ile?Ser?Val?Val?Ser?Thr?Val?Pro

215 220 225

act?ctg?gct?ggt?ctg?tgg?cca?gca?gaa?gca?ttg?tca?cag?gtc?cgc?ttg 835

Thr?Leu?Ala?Gly?Leu?Trp?Pro?Ala?Glu?Ala?Leu?Ser?Gln?Val?Arg?Leu

230 235 240 245

ctc?atc?gtc?ggc?ggc?gag?gct?tgc?tcg?cag?gag?ctc?gtt?gaa?cgc?tta 883

Leu?Ile?Val?Gly?Gly?Glu?Ala?Cys?Ser?Gln?Glu?Leu?Val?Glu?Arg?Leu

250 255 260

tcg?acg?cct?gac?cgc?gag?gtg?tgg?aac?act?tac?ggc?ccc?acc?gaa?gca 931

Ser?Thr?Pro?Asp?Arg?Glu?Val?Trp?Asn?Thr?Tyr?Gly?Pro?Thr?Glu?Ala

265 270 275

acg?gtg?gtt?gcc?tgt?ggc?act?caa?ctc?tat?gct?ggt?cag?cca?gtg?ggc 979

Thr?Val?Val?Ala?Cys?Gly?Thr?Gln?Leu?Tyr?Ala?Gly?Gln?Pro?Val?Gly

280 285 290

att?ggt?ttg?cca?ctt?gct?ggt?tgg?gat?ctt?gtt?gtt?gtc?gac?gat?gcc 1027

Ile?Gly?Leu?Pro?Leu?Ala?Gly?Trp?Asp?Leu?Val?Val?Val?Asp?Asp?Ala

295 300 305

ggc?gaa?cct?gtc?gga?atc?ggc?gag?gtc?ggc?gaa?ttg?gtc?atc?ggt?ggt 1075

Gly?Glu?Pro?Val?Gly?Ile?Gly?Glu?Val?Gly?Glu?Leu?Val?Ile?Gly?Gly

310 315 320 325

gtg?ggt?ctt?gca?cgc?tac?ctt?gat?cca?gaa?aaa?gac?cgc?gag?aag?tat 1123

Val?Gly?Leu?Ala?Arg?Tyr?Leu?Asp?Pro?Glu?Lys?Asp?Arg?Glu?Lys?Tyr

330 335 340

gcg?cca?ctg?aag?tct?gtt?ggt?tgg?acc?cgc?gct?tat?cgt?tcc?ggt?gac 1171

Ala?Pro?Leu?Lys?Ser?Val?Gly?Trp?Thr?Arg?Ala?Tyr?Arg?Ser?Gly?Asp

345 350 355

cac?gtt?cgt?ctg?gaa?gaa?gat?ggc?ctc?tac?ttt?gtg?ggc?cgc?gtt?gat 1219

His?Val?Arg?Leu?Glu?Glu?Asp?Gly?Leu?Tyr?Phe?Val?Gly?Arg?Val?Asp

360 365 370

gat?cag?gtg?aaa?atc?ggc?ggt?cga?cgc?atc?gag?ctc?ggt?gaa?gtt?gat 1267

Asp?Gln?Val?Lys?Ile?Gly?Gly?Arg?Arg?Ile?Glu?Leu?Gly?Glu?Val?Asp

375 380 385

gcc?aat?gtg?gca?gcg?ctt?tcc?aac?gtt?cgt?tcc?tcc?gca?gtg?gtt?gtt 1315

Ala?Asn?Val?Ala?Ala?Leu?Ser?Asn?Val?Arg?Ser?Ser?Ala?Val?Val?Val

390 395 400 405

cag?acc?act?ggt?gcg?gat?caa?aaa?gtt?ctg?gtt?gca?tac?gtt?tct?ttg 1363

Gln?Thr?Thr?Gly?Ala?Asp?Gln?Lys?Val?Leu?Val?Ala?Tyr?Val?Ser?Leu

410 415 420

gaa?gat?gct?gca?gct?gga?ttt?gat?cac?aac?gtc?gcg?act?gcc?cga?ctc 1411

Glu?Asp?Ala?Ala?Ala?Gly?Phe?Asp?His?Asn?Val?Ala?Thr?Ala?Arg?Leu

425 430 435

acc?gaa?acc?atg?cct?gct?gct?ttg?gtt?ccg?cgc?att?cac?gtg?atg?gat 1459

Thr?Glu?Thr?Met?Pro?Ala?Ala?Leu?Val?Pro?Arg?Ile?His?Val?Met?Asp

440 445 450

gat?ctg?cct?gtc?acc?acc?tcc?ggc?aag?gtt?gat?aag?aag?tct?ttg?ccg 1507

Asp?Leu?Pro?Val?Thr?Thr?Ser?Gly?Lys?Val?Asp?Lys?Lys?Ser?Leu?Pro

455 460 465

tgg?cct?ctt?cct?ggc?acc?gtg?gtg?gaa?gct?aat?gac?ctc?agc?gca?acg 1555

Trp?Pro?Leu?Pro?Gly?Thr?Val?Val?Glu?Ala?Asn?Asp?Leu?Ser?Ala?Thr

470 475 480 485

gaa?gcg?tgg?att?gct?cag?gaa?tgg?gtc?gat?atc?ctc?ggc?act?tct?gtg 1603

Glu?Ala?Trp?lle?Ala?Gln?Glu?Trp?Val?Asp?Ile?Leu?Gly?Thr?Ser?Val

490 495 500

agc?agc?aaa?gac?gcc?gac?ttc?ttc?tcc?ctt?ggc?ggt?acc?tct?ctc?gcg 1651

Ser?Ser?Lys?Asp?Ala?Asp?Phe?Phe?Ser?Leu?Gly?Gly?Thr?Ser?Leu?Ala

505 510 515

gct?gcg?act?ttg?gtt?ggc?cgg?gta?cgc?gca?aag?gtt?ccc?acc?gct?gcg 1699

Ala?Ala?Thr?Leu?Val?Gly?Arg?Val?Arg?Ala?Lys?Val?Pro?Thr?Ala?Ala

520 525 530

gtg?cgt?gat?ctt?tac?gat?cac?cct?cgc?ttg?gag?aaa?ttc?gcc?gag?cgt 1747

Val?Arg?Asp?Leu?Tyr?Asp?His?Pro?Arg?Leu?Glu?Lys?Phe?Ala?Glu?Arg

535 540 545

gtc?gag?gct?atc?gcc?gcc?gac?act?ggc?att?tct?ttg?gag?gcg?cca?aac 1795

Val?Glu?Ala?Ile?Ala?Ala?Asp?Thr?Gly?Ile?Ser?Leu?Glu?Ala?Pro?Asn

550 555 560 565

cag?gtg?gag?gag?cgc?gtc?gtc?aag?cct?gtt?tct?ttt?ggc?act?cgt?gtg 1843

Gln?Val?Glu?Glu?Arg?Val?Val?Lys?Pro?Val?Ser?Phe?Gly?Thr?Arg?Val

570 575 580

atg?cag?acc?ctc?atc?cag?att?ccg?atc?atg?acg?ctg?caa?gca?gca?cag 1891

Met?Gln?Thr?Leu?Ile?Gln?Ile?Pro?Ile?Met?Thr?Leu?Gln?Ala?Ala?Gln

585 590 595

tgg?att?gca?tgg?ttg?ctg?ttg?ggc?aac?aac?atc?atg?gca?gcg?ctt?gat 1939

Trp?Ile?Ala?Trp?Leu?Leu?Leu?Gly?Asn?Asn?Ile?Met?Ala?Ala?Leu?Asp

600 605 610

ttc?gat?tgg?gct?gtt?cat?gtc?tcc?tgg?tgg?ctt?gtc?atc?ggc?atg?att 1987

Phe?Asp?Trp?Ala?Val?His?Val?Ser?Trp?Trp?Leu?Val?Ile?Gly?Met?Ile

615 620 625

ttg?gtg?ttc?gct?acc?ccg?att?ggt?cgc?ttg?ccg?atc?ggc?ggt?tgg?ggc 2035

Leu?Val?Phe?Ala?Thr?Pro?Ile?Gly?Arg?Leu?Pro?Ile?Gly?Gly?Trp?Gly

630 635 640 645

gcc?cgc?atc?atc?acc?cgt?ggc?ata?act?cct?ggc?tcc?tac?cct?cgt?ggc 2083

Ala?Arg?Ile?Ile?Thr?Arg?Gly?Ile?Thr?Pro?Gly?Ser?Tyr?Pro?Arg?Gly

650 655 660

ggt?tcc?act?cac?ctg?cgc?att?tgg?tcc?gcc?gag?cgc?ctt?gct?gat?gcc 2131

Gly?Ser?Thr?His?Leu?Arg?Ile?Trp?Ser?Ala?Glu?Arg?Leu?Ala?Asp?Ala

665 670 675

tct?ggc?tct?cgc?aat?att?tct?ggc?gca?acc?tgg?gtg?aac?tac?ttc?gcg 2179

Ser?Gly?Ser?Arg?Asn?Ile?Ser?Gly?Ala?Thr?Trp?Val?Asn?Tyr?Phe?Ala

680 685 690

cgt?tcc?ctg?ggt?gtg?aag?atg?ggc?aag?ggc?gtg?gat?ctt?cac?tcc?ctg 2227

Arg?Ser?Leu?Gly?Val?Lys?Met?Gly?Lys?Gly?Val?Asp?Leu?His?Ser?Leu

695 700 705

cca?cca?atc?act?ggc?ctt?ttg?acc?ttg?ggc?aac?aat?gtt?tcc?atc?gag 2275

Pro?Pro?Ile?Thr?Gly?Leu?Leu?Thr?Leu?Gly?Asn?Asn?Val?Ser?Ile?Glu

710 715 720 725

caa?gaa?gtt?gac?ctt?cgt?ggc?tac?tgg?ctc?gac?ggc?gat?atc?ctg?cgt 2323

Gln?Glu?Val?Asp?Leu?Arg?Gly?Tyr?Trp?Leu?Asp?Gly?Asp?Ile?Leu?Arg

730 735 740

gta?ggc?acc?att?gag?gtc?cat?gac?aac?gct?cgc?atc?ggc?gct?cgt?tcc 2371

Val?Gly?Thr?Ile?Glu?Val?His?Asp?Asn?Ala?Arg?Ile?Gly?Ala?Arg?Ser

745 750 755

acc?ctg?ctt?ccc?ggc?acc?gtg?gtg?ggc?acc?ggc?gct?cac?ctg?ctg?cct 2419

Thr?Leu?Leu?Pro?Gly?Thr?Val?Val?Gly?Thr?Gly?Ala?His?Leu?Leu?Pro

760 765 770

ggt?tca?aca?gtg?act?ggt?gat?aag?acc?atc?aag?cct?ggt?tct?cgt?tgg 2467

Gly?Ser?Thr?Val?Thr?Gly?Asp?Lys?Thr?Ile?Lys?Pro?Gly?Ser?Arg?Trp

775 780 785

gct?ggc?tcc?cct?gca?caa?aag?gtg?ggt?cgt?gca?aag?cac?cgg?ttc?cca 2515

Ala?Gly?Ser?Pro?Ala?Gln?Lys?Val?Gly?Arg?Ala?Lys?His?Arg?Phe?Pro

790 795 800 805

acc?tcc?cat?cct?cca?cgc?agg?tcc?cgg?tgg?gtt?ccg?gtg?ttc?ggc?gcg 2563

Thr?Ser?His?Pro?Pro?Arg?Arg?Ser?Arg?Trp?Val?Pro?Val?Phe?Gly?Ala

810 815 820

acc?tcc?atc?gtg?ttg?tcg?ctg?ctg?cca?ctt?cag?gct?ctc?gct?att?ggc 2611

Thr?Ser?Ile?Val?Leu?Ser?Leu?Leu?Pro?Leu?Gln?Ala?Leu?Ala?Ile?Gly

825 830 835

gct?gct?atc?acc?ttg?tgg?ctg?gcc?acg?att?agc?ccg?ctt?cca?ctg?atc 2659

Ala?Ala?Ile?Thr?Leu?Trp?Leu?Ala?Thr?Ile?Ser?Pro?Leu?Pro?Leu?Ile

840 845 850

tgg?ggt?gtg?ctg?gtt?ttt?gct?acc?gtc?ggc?gcg?ttg?gct?gcg?ttc?ttt 2707

Trp?Gly?Val?Leu?Val?Phe?Ala?Thr?Val?Gly?Ala?Leu?Ala?Ala?Phe?Phe

855 860 865

gct?tac?acc?gtg?acc?atc?tgg?gtg?ctt?gtc?cgt?ttg?atc?cag?atc?ggc 2755

Ala?Tyr?Thr?Val?Thr?Ile?Trp?Val?Leu?Val?Arg?Leu?Ile?Gln?Ile?Gly

870 875 880 885

atc?aag?ggc?ggc?acc?gca?cca?gtg?agg?tcc?cgt?ctt?ggt?tgg?cag?gtc 2803

Ile?Lys?Gly?Gly?Thr?Ala?Pro?Val?Arg?Ser?Arg?Leu?Gly?Trp?Gln?Val

890 895 900

tgg?gca?gtt?caa?cgc?ctc?atg?gac?gat?gcc?cgc?acc?tat?ctc?ttc?ccg 2851

Trp?Ala?Val?Gln?Arg?Leu?Met?Asp?Asp?Ala?Arg?Thr?Tyr?Leu?Phe?Pro

905 910 915

ctc?tac?gca?tcc?caa?ctg?acc?cca?ctg?tgg?ttc?cgc?agc?ttg?ggc?gcg 2899

Leu?Tyr?Ala?Ser?Gln?Leu?Thr?Pro?Leu?Trp?Phe?Arg?Ser?Leu?Gly?Ala

920 925 930

aag?atc?ggc?aag?gat?gtt?gag?atc?tcc?acc?gcg?gtg?atg?gtt?cct?aaa 2947

Lys?Ile?Gly?Lys?Asp?Val?Glu?Ile?Ser?Thr?Ala?Val?Met?Val?Pro?Lys

935 940 945

ctg?gct?gat?atc?cgc?gaa?ggc?gca?ttc?ctg?gcc?gat?gac?acc?ctc?atc 2995

Leu?Ala?Asp?Ile?Arg?Glu?Gly?Ala?Phe?Leu?Ala?Asp?Asp?Thr?Leu?Ile

950 955 960 965

ggt?ggc?tat?gag?ctg?ggt?aat?ggt?tgg?ctg?ctc?agt?ggt?gaa?acc?cgc 3043

Gly?Gly?Tyr?Glu?Leu?Gly?Asn?Gly?Trp?Leu?Leu?Ser?Gly?Glu?Thr?Arg

970 975 980

gtg?ggt?aag?cgt?tcc?ttc?att?ggt?aac?tct?ggc?atc?gca?gga?cct?gag 3091

Val?Gly?Lys?Arg?Ser?Phe?Ile?Gly?Asn?Ser?Gly?Ile?Ala?Gly?Pro?Glu

985 990 995

cgc?aag?ctc?gct?aag?aac?tcc?ctg?gtt?gca?gtg?ctc?tcc?tcc?acc?ccg 3139

Arg?Lys?Leu?Ala?Lys?Asn?Ser?Leu?Val?Ala?Val?Leu?Ser?Ser?Thr?Pro

1000 1005 1010

aag?aag?gct?aag?gcc?aac?tcc?aac?tgg?tgg?ggt?tcc?cct?cca?gag?cgc 3187

Lys?Lys?Ala?Lys?Ala?Asn?Ser?Asn?Trp?Trp?Gly?Ser?Pro?Pro?Glu?Arg

1015 1020 1025

atg cgt?cgt?gtc?act?gtc?gaa?gtt?gat?gag?ggc?gaa?gca?aag?acc?tac 3235

Met Arg?Arg?Val?Thr?Val?Glu?Val?Asp?Glu?Gly?Glu?Ala?Lys?Thr?Tyr

1030 1035 1040 1045

agc?cct?ggc?ttt?ggt?gtg?aag?ttt?gca?cgt?ggc?gcg?gtg?gaa?acc?gca 3283

Ser?Pro?Gly?Phe?Gly?Val?Lys?Phe?Ala?Arg?Gly?Ala?Val?Glu?Thr?Ala

1050 1055 1060

cgt?ctg?ctt?gct?cca?ata?acc?tct?ggt?gtg?ttg?gct?gcg?ctg?tca?ctg 3331

Arg?Leu?Leu?Ala?Pro?lle?Thr?Ser?Gly?Val?Leu?Ala?Ala?Leu?Ser?Leu

1065 1070 1075

ctg?ctc?atg?cag?tac?ctg?ctc?act?gag?ttc?aac?atg?tgg?atc?acc?tgg 3379

Leu?Leu?Met?Gln?Tyr?Leu?Leu?Thr?Glu?Phe?Asn?Met?Trp?Ile?Thr?Trp

1080 1085 1090

ttg?ctt?ggc?gga?ctg?atc?ctc?atg?acg?gtt?ggt?gtg?ctc?gcc?atg?ggc 3427

Leu?Leu?Gly?Gly?Leu?Ile?Leu?Met?Thr?Val?Gly?Val?Leu?Ala?Met?Gly

1095 1100 1105

att?acg?gtt?gtg?atg?aag?tgg?gtt?tgc?gtc?ggc?aag?cat?aag?ccg?tct 3475

Ile?Thr?Val?Val?Met?Lys?Trp?Val?Cys?Val?Gly?Lys?His?Lys?Pro?Ser

1110 1115 1120 1125

gag?cac?cct?ctc?ttc?agc?cgc?ttt?gtg?tgg?ctg?aat?gag?ctg?caa?gat 3523

Glu?His?Pro?Leu?Phe?Ser?Arg?Phe?Val?Trp?Leu?Asn?Glu?Leu?Gln?Asp

1130 1135 1140

gcg?ttc?gtg?gaa?tcc?gtg?gct?ggc?cca?tgg?ttc?ctc?gtg?ccc?aac?ctg 3571

Ala?Phe?Val?Glu?Ser?Val?Ala?Gly?Pro?Trp?Phe?Leu?Val?Pro?Asn?Leu

1145 1150 1155

ggc?acc?ggc?gcg?ctg?aac?gcc?ggc?atg?agc?gcg?ctt?ggc?gca?cac?atc 3619

Gly?Thr?Gly?Ala?Leu?Asn?Ala?Gly?Met?Ser?Ala?Leu?Gly?Ala?His?Ile

1160 1165 1170

ggc?cgt?ggc?gca?tgg?atc?gaa?tcc?tac?tgg?ctg?ccg?gaa?acc?gac?ctc 3667

Gly?Arg?Gly?Ala?Trp?Ile?Glu?Ser?Tyr?Trp?Leu?Pro?Glu?Thr?Asp?Leu

1175 1180 1185

tgc?tac?atc?ggc?aag?ggc?gca?acc?gtg?ggc?cct?ggc?gtg?gtc?gtg?cag 3715

Cys?Tyr?Ile?Gly?Lys?Gly?Ala?Thr?Val?Gly?Pro?Gly?Val?Val?Val?Gln

1190 1195 1200 1205

acc?cac?ctc?ttc?cag?gac?cgc?gtg?atg?agc?cta?gat?acg?gtg?acc?gtc 3763

Thr?His?Leu?Phe?Gln?Asp?Arg?Val?Met?Ser?Leu?Asp?Thr?Val?Thr?Val

1210 1215 1220

gct?gac?ggc?gcc?acc?cta?gcg?gac?cac?tcc?gtt?gcc?ctt?cct?gct?tcg 3811

Ala?Asp?Gly?Ala?Thr?Leu?Ala?Asp?His?Ser?Val?Ala?Leu?Pro?Ala?Ser

1225 1230 1235

ctt?atc?gac?gcc?tcc?gcc?acc?atc?ggc?cca?ggc?tcg?ctg?gtg?atg?cgc 3859

Leu?Ile?Asp?Ala?Ser?Ala?Thr?Ile?Gly?Pro?Gly?Ser?Leu?Val?Met?Arg

1240 1245 1250

ggc?gac?aag?gta?cca?gcg?cat?acc?cgc?tgg?caa?ggc?aac?cca?att?gag 3907

Gly?Asp?Lys?Val?Pro?Ala?His?Thr?Arg?Trp?Gln?Gly?Asn?Pro?Ile?Glu

1255 1260 1265

ccg?tgg?agc?aac?tct?taaataacaa?caatcagccg?gat 3945

Pro?Trp?Ser?Asn?Ser

1270

<210>360

<211>1274

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>360

Leu?Trp?Asp?Val?Leu?Glu?Ser?Val?Ala?Ser?Thr?Tyr?Pro?Glu?Ala?Ala

1 5 10 15

Ala?Ile?Asp?Asp?Gly?Gln?Val?Leu?Thr?Tyr?Ala?Glu?Leu?Met?Glu?Glu

20 25 30

Val?Thr?Ala?Leu?Ala?Asp?Ser?Ile?His?Ala?Gln?Gly?Ile?Arg?Arg?Gly

35 40 45

Asp?Arg?Ile?Gly?Ile?Arg?Met?Pro?Ser?Gly?Thr?Arg?Asp?Leu?Tyr?Ile

50 55 60

Ala?Ile?Leu?Ala?Thr?Leu?Ala?Ala?Gly?Ala?Ala?Tyr?Val?Pro?Val?Asp

65 70 75 80

Ala?Asp?Asp?Pro?Glu?Glu?Arg?Ala?Glu?Met?Val?Phe?Gly?Glu?Ala?Asn

85 90 95

Ile?Asn?Ala?Leu?Phe?Asp?Ala?Thr?Gly?Phe?His?Met?Leu?Arg?Pro?Thr

100 105 110

Ala?Gly?Gly?Asp?Thr?Arg?Arg?Pro?Arg?Leu?Asp?Asp?Thr?Ala?Trp?Ile

115 120 125

Ile?Phe?Thr?Ser?Gly?Ser?Thr?Gly?Lys?Pro?Lys?Gly?Val?Ala?Val?Ser

130 135 140

His?Arg?Ser?Ala?Ala?Ala?Phe?Val?Asp?Ala?Glu?Ala?Gln?Met?Phe?Leu

145 150 155 160

Val?Asp?His?Pro?Ser?Gly?Pro?Leu?Gly?Pro?Glu?Asp?Arg?Val?Leu?Ala

165 170 175

Gly?Leu?Ser?Val?Ala?Phe?Asp?Ala?Ser?Cys?Glu?Glu?Met?Trp?Leu?Ala

180 185 190

Trp?Gly?His?Gly?Ala?Cys?Leu?Val?Pro?Ala?Pro?Arg?Ser?Leu?Val?Arg

195 200 205

Ser?Gly?Met?Asp?Leu?Gly?Pro?Trp?Leu?Ile?Arg?Arg?Asp?Ile?Ser?Val

210 215 220

Val?Ser?Thr?Val?Pro?Thr?Leu?Ala?Gly?Leu?Trp?Pro?Ala?Glu?Ala?Leu

225 230 235 240

Ser?Gln?Val?Arg?Leu?Leu?Ile?Val?Gly?Gly?Glu?Ala?Cys?Ser?Gln?Glu

245 250 255

Leu?Val?Glu?Arg?Leu?Ser?Thr?Pro?Asp?Arg?Glu?Val?Trp?Asn?Thr?Tyr

260 265 270

Gly?Pro?Thr?Glu?Ala?Thr?Val?Val?Ala?Cys?Gly?Thr?Gln?Leu?Tyr?Ala

275 280 285

Gly?Gln?Pro?Val?Gly?Ile?Gly?Leu?Pro?Leu?Ala?Gly?Trp?Asp?Leu?Val

290 295 300

Val?Val?Asp?Asp?Ala?Gly?Glu?Pro?Val?Gly?Ile?Gly?Glu?Val?Gly?Glu

305 310 315 320

Leu?Val?Ile?Gly?Gly?Val?Gly?Leu?Ala?Arg?Tyr?Leu?Asp?Pro?Glu?Lys

325 330 335

Asp?Arg?Glu?Lys?Tyr?Ala?Pro?Leu?Lys?Ser?Val?Gly?Trp?Thr?Arg?Ala

340 345 350

Tyr?Arg?Ser?Gly?Asp?His?Val?Arg?Leu?Glu?Glu?Asp?Gly?Leu?Tyr?Phe

355 360 365

Val?Gly?Arg?Val?Asp?Asp?Gln?Val?Lys?Ile?Gly?Gly?Arg?Arg?Ile?Glu

370 375 380

Leu?Gly?Glu?Val?Asp?Ala?Asn?Val?Ala?Ala?Leu?Ser?Asn?Val?Arg?Ser

385 390 395 400

Ser?Ala?Val?Val?Val?Gln?Thr?Thr?Gly?Ala?Asp?Gln?Lys?Val?Leu?Val

405 410 415

Ala?Tyr?Val?Ser?Leu?Glu?Asp?Ala?Ala?Ala?Gly?Phe?Asp?His?Asn?Val

420 425 430

Ala?Thr?Ala?Arg?Leu?Thr?Glu?Thr?Met?Pro?Ala?Ala?Leu?Val?Pro?Arg

435 440 445

Ile?His?Val?Met?Asp?Asp?Leu?Pro?Val?Thr?Thr?Ser?Gly?Lys?Val?Asp

450 455 460

Lys?Lys?Ser?Leu?Pro?Trp?Pro?Leu?Pro?Gly?Thr?Val?Val?Glu?Ala?Asn

465 470 475 480

Asp?Leu?Ser?Ala?Thr?Glu?Ala?Trp?Ile?Ala?Gln?Glu?Trp?Val?Asp?Ile

485 490 495

Leu?Gly?Thr?Ser?Val?Ser?Ser?Lys?Asp?Ala?Asp?Phe?Phe?Ser?Leu?Gly

500 505 510

Gly?Thr?Ser?Leu?Ala?Ala?Ala?Thr?Leu?Val?Gly?Arg?Val?Arg?Ala?Lys

515 520 525

Val?Pro?Thr?Ala?Ala?Val?Arg?Asp?Leu?Tyr?Asp?His?Pro?Arg?Leu?Glu

530 535 540

Lys?Phe?Ala?Glu?Arg?Val?Glu?Ala?Ile?Ala?Ala?Asp?Thr?Gly?Ile?Ser

545 550 555 560

Leu?Glu?Ala?Pro?Asn?Gln?Val?Glu?Glu?Arg?Val?Val?Lys?Pro?Val?Ser

565 570 575

Phe?Gly?Thr?Arg?Val?Met?Gln?Thr?Leu?Ile?Gln?Ile?Pro?Ile?Met?Thr

580 585 590

Leu?Gln?Ala?Ala?Gln?Trp?Ile?Ala?Trp?Leu?Leu?Leu?Gly?Asn?Asn?Ile

595 600 605

Met?Ala?Ala?Leu?Asp?Phe?Asp?Trp?Ala?Val?His?Val?Ser?Trp?Trp?Leu

610 615 620

Val?Ile?Gly?Met?Ile?Leu?Val?Phe?Ala?Thr?Pro?Ile?Gly?Arg?Leu?Pro

625 630 635 640

Ile?Gly?Gly?Trp?Gly?Ala?Arg?Ile?Ile?Thr?Arg?Gly?Ile?Thr?Pro?Gly

645 650 655

Ser?Tyr?Pro?Arg?Gly?Gly?Ser?Thr?His?Leu?Arg?Ile?Trp?Ser?Ala?Glu

660 665 670

Arg?Leu?Ala?Asp?Ala?Ser?Gly?Ser?Arg?Asn?Ile?Ser?Gly?Ala?Thr?Trp

675 680 685

Val?Asn?Tyr?Phe?Ala?Arg?Ser?Leu?Gly?Val?Lys?Met?Gly?Lys?Gly?Val

690 695 700

Asp?Leu?His?Ser?Leu?Pro?Pro?Ile?Thr?Gly?Leu?Leu?Thr?Leu?Gly?Asn

705 710 715 720

Asn?Val?Ser?Ile?Glu?Gln?Glu?Val?Asp?Leu?Arg?Gly?Tyr?Trp?Leu?Asp

725 730 735

Gly?Asp?Ile?Leu?Arg?Val?Gly?Thr?Ile?Glu?Val?His?Asp?Asn?Ala?Arg

740 745 750

Ile?Gly?Ala?Arg?Ser?Thr?Leu?Leu?Pro?Gly?Thr?Val?Val?Gly?Thr?Gly

755 760 765

Ala?His?Leu?Leu?Pro?Gly?Ser?Thr?Val?Thr?Gly?Asp?Lys?Thr?Ile?Lys

770 775 780

Pro?Gly?Ser?Arg?Trp?Ala?Gly?Ser?Pro?Ala?Gln?Lys?Val?Gly?Arg?Ala

785 790 795 800

Lys?His?Arg?Phe?Pro?Thr?Ser?His?Pro?Pro?Arg?Arg?Ser?Arg?Trp?Val

805 810 815

Pro?Val?Phe?Gly?Ala?Thr?Ser?Ile?Val?Leu?Ser?Leu?Leu?Pro?Leu?Gln

820 825 830

Ala?Leu?Ala?Ile?Gly?Ala?Ala?Ile?Thr?Leu?Trp?Leu?Ala?Thr?Ile?Ser

835 840 845

Pro?Leu?Pro?Leu?Ile?Trp?Gly?Val?Leu?Val?Phe?Ala?Thr?Val?Gly?Ala

850 855 860

Leu?Ala?Ala?Phe?Phe?Ala?Tyr?Thr?Val?Thr?Ile?Trp?Val?Leu?Val?Arg

865 870 875 880

Leu?Ile?Gln?Ile?Gly?Ile?Lys?Gly?Gly?Thr?Ala?Pro?Val?Arg?Ser?Arg

885 890 895

Leu?Gly?Trp?Gln?Val?Trp?Ala?Val?Gln?Arg?Leu?Met?Asp?Asp?Ala?Arg

900 905 910

Thr?Tyr?Leu?Phe?Pro?Leu?Tyr?Ala?Ser?Gln?Leu?Thr?Pro?Leu?Trp?Phe

915 920 925

Arg?Ser?Leu?Gly?Ala?Lys?Ile?Gly?Lys?Asp?Val?Glu?Ile?Ser?Thr?Ala

930 935 940

Val?Met?Val?Pro?Lys?Leu?Ala?Asp?Ile?Arg?Glu?Gly?Ala?Phe?Leu?Ala

945 950 955 960

Asp?Asp?Thr?Leu?Ile?Gly?Gly?Tyr?Glu?Leu?Gly?Asn?Gly?Trp?Leu?Leu

965 970 975

Ser?Gly?Glu?Thr?Arg?Val?Gly?Lys?Arg?Ser?Phe?Ile?Gly?Asn?Ser?Gly

980 985 990

Ile?Ala?Gly?Pro?Glu?Arg?Lys?Leu?Ala?Lys?Asn?Ser?Leu?Val?Ala?Val

995 1000 1005

Leu?Ser?Ser?Thr?Pro?Lys?Lys?Ala?Lys?Ala?Asn?Ser?Asn?Trp?Trp?Gly

1010 1015 1020

Ser?Pro?Pro?Glu?Arg?Met?Arg?Arg?Val?Thr?Val?Glu?Val?Asp?Glu?Gly

1025 1030 1035 1040

Glu?Ala?Lys?Thr?Tyr?Ser?Pro?Gly?Phe?Gly?Val?Lys?Phe?Ala?Arg?Gly

1045 1050 1055

Ala?Val?Glu?Thr?Ala?Arg?Leu?Leu?Ala?Pro?Ile?Thr?Ser?Gly?Val?Leu

1060 1065 1070

Ala?Ala?Leu?Ser?Leu?Leu?Leu?Met?Gln?Tyr?Leu?Leu?Thr?Glu?Phe?Asn

1075 1080 1085

Met?Trp?Ile?Thr?Trp?Leu?Leu?Gly?Gly?Leu?Ile?Leu?Met?Thr?Val?Gly

1090 1095 1100

Val?Leu?Ala?Met?Gly?Ile?Thr?Val?Val?Met?Lys?Trp?Val?Cys?Val?Gly

1105 1110 1115 1120

Lys?His?Lys?Pro?Ser?Glu?His?Pro?Leu?Phe?Ser?Arg?Phe?Val?Trp?Leu

1125 1130 1135

Asn?Glu?Leu?Gln?Asp?Ala?Phe?Val?Glu?Ser?Val?Ala?Gly?Pro?Trp?Phe

1140 1145 1150

Leu?Val?Pro?Asn?Leu?Gly?Thr?Gly?Ala?Leu?Asn?Ala?Gly?Met?Ser?Ala

1155 1160 1165

Leu?Gly?Ala?His?Ile?Gly?Arg?Gly?Ala?Trp?Ile?Glu?Ser?Tyr?Trp?Leu

1170 1175 1180

Pro?Glu?Thr?Asp?Leu?Cys?Tyr?Ile?Gly?Lys?Gly?Ala?Thr?Val?Gly?Pro

1185 1190 1195 1200

Gly?Val?Val?Val?Gln?Thr?His?Leu?Phe?Gln?Asp?Arg?Val?Met?Ser?Leu

1205 1210 1215

Asp?Thr?Val?Thr?Val?Ala?Asp?Gly?Ala?Thr?Leu?Ala?Asp?His?Ser?Val

1220 1225 1230

Ala?Leu?Pro?Ala?Ser?Leu?Ile?Asp?Ala?Ser?Ala?Thr?Ile?Gly?Pro?Gly

1235 1240 1245

Ser?Leu?Val?Met?Arg?Gly?Asp?Lys?Val?Pro?Ala?His?Thr?Arg?Trp?Gln

1250 1255 1260

Gly?Asn?Pro?Ile?Glu?Pro?Trp?Ser?Asn?Ser

1265 1270

<210>36l

<211>609

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(586)

<223>RXN01997

<400>361

aaaaaggtgg?gaaacttagc?caatccaaag?cccaaaaatg?cgggttatgc?tgcgctaacc?60

tatgctgaca?gccttgcgga?agttgtgtac?gttaggggcc?atg?aca?atc?aac?gag 115

Met?Thr?Ile?Asn?Glu

1 5

aag?atc?gca?tca?gct?ttc?aac?aac?caa?gtg?act?gca?gag?ctt?gaa?gct 163

Lys?Ile?Ala?Ser?Ala?Phe?Asn?Asn?Gln?Val?Thr?Ala?Glu?Leu?Glu?Ala

10 15 20

tca?atg?gtg?tac?ctt?cag?ctc?tcc?tac?gtt?cta?gac?gat?ctg?ggc?ctc 211

Ser?Met?Val?Tyr?Leu?Gln?Leu?Ser?Tyr?Val?Leu?Asp?Asp?Leu?Gly?Leu

25 30 35

acc?ggc?atg?cgc?gac?tgg?atg?aag?gca?cag?agc?aaa?gaa?gag?ctc?gaa 259

Thr?Gly?Met?Arg?Asp?Trp?Met?Lys?Ala?Gln?Ser?Lys?Glu?Glu?Leu?Glu

40 45 50

cac?gca?cag?aag?ttc?gct?cag?cac?ctt?ctt?gac?cgt?gac?tac?acc?cca 307

His?Ala?Gln?Lys?Phe?Ala?Gln?His?Leu?Leu?Asp?Arg?Asp?Tyr?Thr?Pro

55 60 65

cag?atc?ggt?gac?att?gca?cca?cca?aag?ctt?gat?gtc?acc?tcc?gct?atc 355

Gln?Ile?Gly?Asp?Ile?Ala?Pro?Pro?Lys?Leu?Asp?Val?Thr?Ser?Ala?Ile

70 75 80 85

gag?gct?ttc?gag?gct?tcc?ctg?gca?cac?gag?cag?aag?atc?tcc?ggc?ctg 403

Glu?Ala?Phe?Glu?Ala?Ser?Leu?Ala?His?Glu?Gln?Lys?Ile?Ser?Gly?Leu

90 95 100

atc?cgc?gag?ctc?gct?gcc?atc?cag?gac?gct?gag?aag?gac?tac?gat?tcc 451

Ile?Arg?Glu?Leu?Ala?Ala?Ile?Gln?Asp?Ala?Glu?Lys?Asp?Tyr?Asp?Ser

105 110 115

cgc?gca?ctg?atc?gac?tgg?ttc?ctc?aac?gag?cag?atc?gaa?gaa?gaa?gca 499

Arg?Ala?Leu?Ile?Asp?Trp?Phe?Leu?Asn?Glu?Gln?Ile?Glu?Glu?Glu?Ala

120 125 130

acc?gtc?ggc?gag?atc?atc?gac?cgc?ctc?cgt?atc?gct?ggt?gat?tcc?ggt 547

Thr?Val?Gly?Glu?Ile?Ile?Asp?Arg?Leu?Arg?Ile?Ala?Gly?Asp?Ser?Gly

135 140 145

tcc?gga?atc?ctg?cgc?atc?gac?ggc?gaa?ctc?ggc?tcc?cgc?taaattcccc 596

Ser?Gly?Ile?Leu?Arg?Ile?Asp?Gly?Glu?Leu?Gly?Ser?Arg

150 155 160

gcagttttta?atg 609

<210>362

<211>162

<212>PRT

＜2l3〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>362

Met?Thr?Ile?Asn?Glu?Lys?Ile?Ala?Ser?Ala?Phe?Asn?Asn?Gln?Val?Thr

1 5 10 15

Ala?Glu?Leu?Glu?Ala?Ser?Met?Val?Tyr?Leu?Gln?Leu?Ser?Tyr?Val?Leu

20 25 30

Asp?Asp?Leu?Gly?Leu?Thr?Gly?Met?Arg?Asp?Trp?Met?Lys?Ala?Gln?Ser

35 40 45

Lys?Glu?Glu?Leu?Glu?His?Ala?Gln?Lys?Phe?Ala?Gln?His?Leu?Leu?Asp

50 55 60

Arg?Asp?Tyr?Thr?Pro?Gln?Ile?Gly?Asp?Ile?Ala?Pro?Pro?Lys?Leu?Asp

65 70 75 80

Val?Thr?Ser?Ala?Ile?Glu?Ala?Phe?Glu?Ala?Ser?Leu?Ala?His?Glu?Gln

85 90 95

Lys?Ile?Ser?Gly?Leu?Ile?Arg?Glu?Leu?Ala?Ala?Ile?Gln?Asp?Ala?Glu

100 105 110

Lys?Asp?Tyr?Asp?Ser?Arg?Ala?Leu?Ile?Asp?Trp?Phe?Leu?Asn?Glu?Gln

115 120 125

Ile?Glu?Glu?Glu?Ala?Thr?Val?Gly?Glu?Ile?Ile?Asp?Arg?Leu?Arg?Ile

130 135 140

Ala?Gly?Asp?Ser?Gly?Ser?Gly?Ile?Leu?Arg?Ile?Asp?Gly?Glu?Leu?Gly

145 150 155 160

Ser?Arg

<210>363

<211>867

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(844)

<223>RXA01848

<400>363

ctgcaaggaa?ctgcgcaggc?gaaggcgcag?actactggaa?aggtaggtac?tgccggatcc?60

ggcgacccct?ttcgctccta?ggcatttgcg?cctggcgtcc?atg?ggg?gag?gag?gac 115

Met?Gly?Glu?Glu?Asp

1 5

tcc?acc?cca?ggt?agg?cgt?tcc?aag?gcg?tat?tcg?cgc?cag?ggc?gct?gat 163

Ser?Thr?Pro?Gly?Arg?Arg?Ser?Lys?Ala?Tyr?Ser?Arg?Gln?Gly?Ala?Asp

10 15 20

gtc?cgc?ccc?atg?aag?ggt?gga?cac?ggc?atc?aac?tta?gtg?ggc?acg?ctc 211

Val?Arg?Pro?Met?Lys?Gly?Gly?His?Gly?Ile?Asn?Leu?Val?Gly?Thr?Leu

25 30 35

atg?gcg?gct?acg?gaa?cgc?ggc?gcc?aac?att?gtt?gaa?ggc?gtg?gtc?gat 259

Met?Ala?Ala?Thr?Glu?Arg?Gly?Ala?Asn?Ile?Val?Glu?Gly?Val?Val?Asp

40 45 50

ttc?cgg?ccc?acg?gac?ctg?cgg?ggt?tcg?ctg?cgc?cgt?ggg?cgc?gaa?gcc 307

Phe?Arg?Pro?Thr?Asp?Leu?Arg?Gly?Ser?Leu?Arg?Arg?Gly?Arg?Glu?Ala

55 60 65

aac?ctc?atc?gtg?ttc?gtc?gtc?gac?aca?tcg?ggg?tcg?atg?gct?gcg?cgt 355

Asn?Leu?Ile?Val?Phe?Val?Val?Asp?Thr?Ser?Gly?Ser?Met?Ala?Ala?Arg

70 75 80 85

tcc?agg?gtg?cgt?gcg?gtc?acc?ggg?act?att?acc?tct?atg?ctt?aac?gac 403

Ser?Arg?Val?Arg?Ala?Val?Thr?Gly?Thr?lle?Thr?Ser?Met?Leu?Asn?Asp

90 95 100

gcc?tac?cag?cgc?cgc?gac?aag?gtt?gcg?gtt?atc?gcg?gtc?aac?ggc?aac 451

Ala?Tyr?Gln?Arg?Arg?Asp?Lys?Val?Ala?Val?Ile?Ala?Val?Asn?Gly?Asn

105 110 115

aag?ccg?aca?ctg?gtg?ttg?aat?cca?aca?aat?tct?gtg?gag?caa?gct?cag 499

Lys?Pro?Thr?Leu?Val?Leu?Asn?Pro?Thr?Asn?Ser?Val?Glu?Gln?Ala?Gln

120 125 130

cag?aaa?tta?aag?gat?atg?ccg?atg?ggt?ggt?cgc?act?cca?ctg?gca?gag 547

Gln?Lys?Leu?Lys?Asp?Met?Pro?Met?Gly?Gly?Arg?Thr?Pro?Leu?Ala?Glu

135 140 145

ggg?ctg?ctc?atg?gcc?aag?gat?ctc?atg?gca?agg?gaa?ctc?cga?aag?gaa 595

Gly?Leu?Leu?Met?Ala?Lys?Asp?Leu?Met?Ala?Arg?Glu?Leu?Arg?Lys?Glu

150 155 160 165

ccc?ggc?cga?cgc?gcg?atc?ctc?atg?gtg?atg?acc?gat?ggc?caa?gac?acc 643

Pro?Gly?Arg?Arg?Ala?Ile?Leu?Met?Val?Met?Thr?Asp?Gly?Gln?Asp?Thr

170 175 180

tcc?gat?gcc?ggc?gaa?gca?ggc?att?gcc?acc?gcg?gcg?gaa?aca?gtg?gtg 691

Ser?Asp?Ala?Gly?Glu?Ala?Gly?Ile?Ala?Thr?Ala?Ala?Glu?Thr?Val?Val

185 190 195

aaa?tca?cga?ctg?tcc?ggc?aac?gtg?gtc?atc?gac?tgc?gaa?ggc?cga?ctc 739

Lys?Ser?Arg?Leu?Ser?Gly?Asn?Val?Val?Ile?Asp?Cys?Glu?Gly?Arg?Leu

200 205 210

aaa?gtg?cgc?aaa?gag?cgc?gcc?ggg?gtg?ttg?gct?gaa?atg?ctc?ggt?ggt 787

Lys?Val?Arg?Lys?Glu?Arg?Ala?Gly?Val?Leu?Ala?Glu?Met?Leu?Gly?Gly

215 220 225

gtg?tgc?gtg?aga?ttg?cgt?gat?ctt?aac?tcc?gag?cac?atc?aaa?atg?gtg 835

Val?Cys?Val?Arg?Leu?Arg?Asp?Leu?Asn?Ser?Glu?His?Ile?Lys?Met?Val

230 235 240 245

att?aac?gcc?tagacaacca?gagtgagggt?ttc 867

Ile?Asn?Ala

<210>364

<211>248

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>364

Met?Gly?Glu?Glu?Asp?Ser?Thr?Pro?Gly?Arg?Arg?Ser?Lys?Ala?Tyr?Ser

1 5 10 15

Arg?Gln?Gly?Ala?Asp?Val?Arg?Pro?Met?Lys?Gly?Gly?His?Gly?Ile?Asn

20 25 30

Leu?Val?Gly?Thr?Leu?Met?Ala?Ala?Thr?Glu?Arg?Gly?Ala?Asn?Ile?Val

35 40 45

Glu?Gly?Val?Val?Asp?Phe?Arg?Pro?Thr?Asp?Leu?Arg?Gly?Ser?Leu?Arg

50 55 60

Arg?Gly?Arg?Glu?Ala?Asn?Leu?Ile?Val?Phe?Val?Val?Asp?Thr?Ser?Gly

65 70 75 80

Ser?Met?Ala?Ala?Arg?Ser?Arg?Val?Arg?Ala?Val?Thr?Gly?Thr?Ile?Thr

85 90 95

Ser?Met?Leu?Asn?Asp?Ala?Tyr?Gln?Arg?Arg?Asp?Lys?Val?Ala?Val?Ile

100 105 110

Ala?Val?Asn?Gly?Asn?Lys?Pro?Thr?Leu?Val?Leu?Asn?Pro?Thr?Asn?Ser

115 120 125

Val?Glu?Gln?Ala?Gln?Gln?Lys?Leu?Lys?Asp?Met?Pro?Met?Gly?Gly?Arg

130 135 140

Thr?Pro?Leu?Ala?Glu?Gly?Leu?Leu?Met?Ala?Lys?Asp?Leu?Met?Ala?Arg

145 150 155 160

Glu?Leu?Arg?Lys?Glu?Pro?Gly?Arg?Arg?Ala?Ile?Leu?Met?Val?Met?Thr

165 170 175

Asp?Gly?Gln?Asp?Thr?Ser?Asp?Ala?Gly?Glu?Ala?Gly?Ile?Ala?Thr?Ala

180 185 190

Ala?Glu?Thr?Val?Val?Lys?Ser?Arg?Leu?Ser?Gly?Asn?Val?Val?Ile?Asp

195 200 205

Cys?Glu?Gly?Arg?Leu?Lys?Val?Arg?Lys?Glu?Arg?Ala?Gly?Val?Leu?Ala

210 215 220

Glu?Met?Leu?Gly?Gly?Val?Cys?Val?Arg?Leu?Arg?Asp?Leu?Asn?Ser?Glu

225 230 235 240

His?Ile?Lys?Met?Val?Ile?Asn?Ala

245

<210>365

<211>1224

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1201)

<223>RXN01849

<400>365

aaaaccttaa?gttgggtggt?taaacccact?aaggtctcac?tttatggatg?tgccaggtca?60

caccaaaaaa?tctcaagaaa?actcacatta?aaggacagta?atg?gcg?tca?caa?cag 115

Met?Ala?Ser?Gln?Gln

1 5

atc?cgc?tat?cca?ttc?tcc?gcg?gtt?gtg?gga?caa?gac?gag?ctt?cgg?ctt 163

Ile?Arg?Tyr?Pro?Phe?Ser?Ala?Val?Val?Gly?Gln?Asp?Glu?Leu?Arg?Leu

10 15 20

gcg?ttg?atc?ctc?act?gcg?att?tcc?cca?cgc?att?ggt?ggc?gtg?gtg?att 211

Ala?Leu?Ile?Leu?Thr?Ala?Ile?Ser?Pro?Arg?Ile?Gly?Gly?Val?Val?Ile

25 30 35

cga?ggt?gag?aag?ggt?aca?gcg?aaa?act?acc?act?gtg?cgt?gct?ttt?gct 259

Arg?Gly?Glu?Lys?Gly?Thr?Ala?Lys?Thr?Thr?Thr?Val?Arg?Ala?Phe?Ala

40 45 50

ggt?ctt?tta?ggt?gat?gcc?cct?ttg?gtg?aac?ttg?cct?ctc?gga?tcc?acg 307

Gly?Leu?Leu?Gly?Asp?Ala?Pro?Leu?Val?Asn?Leu?Pro?Leu?Gly?Ser?Thr

55 60 65

gag?gat?cgt?gtg?gtg?ggt?tcc?ctc?aac?atg?gaa?act?gtg?ttg?acc?acc 355

Glu?Asp?Arg?Val?Val?Gly?Ser?Leu?Asn?Met?Glu?Thr?Val?Leu?Thr?Thr

70 75 80 85

ggc?cgt?gcg?gaa?tat?cag?cca?ggt?ttg?ctc?gcg?cag?gct?gat?ggc?ggt 403

Gly?Arg?Ala?Glu?Tyr?Gln?Pro?Gly?Leu?Leu?Ala?Gln?Ala?Asp?Gly?Gly

90 95 100

gtg?ctg?tat?gtc?gat?gag?gtc?aac?ctc?ttg?gcg?gat?cac?ctg?gtg?gat 451

Val?Leu?Tyr?Val?Asp?Glu?Val?Asn?Leu?Leu?Ala?Asp?His?Leu?Val?Asp

105 110 115

gct?ctg?ctc?gat?gca?gct?gca?agc?ggt?cgc?gtc?agc?att?gag?cgt?gac 499

Ala?Leu?Leu?Asp?Ala?Ala?Ala?Ser?Gly?Arg?Val?Ser?Ile?Glu?Arg?Asp

120 125 130

ggt?att?tcg?cat?tct?tca?cca?gca?aac?ttt?gtg?ttg?gtg?ggc?acc?atg 547

Gly?Ile?Ser?His?Ser?Ser?Pro?Ala?Asn?Phe?Val?Leu?Val?Gly?Thr?Met

135 140 145

aat?ccg?gag?gaa?ggc?gag?ctg?cgc?ccg?cag?ctg?ctg?gac?cgt?ttc?ggt 595

Asn?Pro?Glu?Glu?Gly?Glu?Leu?Arg?Pro?Gln?Leu?Leu?Asp?Arg?Phe?Gly

150 155 160 165

ttg?gct?gtg?gac?gtt?gct?gcg?tct?acg?aac?cct?gag?gtg?cgc?gtg?gag 643

Leu?Ala?Val?Asp?Val?Ala?Ala?Ser?Thr?Asn?Pro?Glu?Val?Arg?Val?Glu

170 175 180

atc?att?cgc?cgc?cgg?ctt?gat?ttt?gaa?aac?gct?cct?gag?cag?ttc?atg 691

Ile?Ile?Arg?Arg?Arg?Leu?Asp?Phe?Glu?Asn?Ala?Pro?Glu?Gln?Phe?Met

185 190 195

gct?aag?tgg?gct?gag?caa?gat?gcg?gac?acc?tcc?aac?cgt?att?ttg?gcg 739

Ala?Lys?Trp?Ala?Glu?Gln?Asp?Ala?Asp?Thr?Ser?Asn?Arg?Ile?Leu?Ala

200 205 210

gct?aag?gat?ttg?ctg?cct?ggt?gtg?gag?ctg?ccg?gat?ctg?atc?ttg?tcg 787

Ala?Lys?Asp?Leu?Leu?Pro?Gly?Val?Glu?Leu?Pro?Asp?Leu?Ile?Leu?Ser

215 220 225

cag?att?gcg?tgg?ttg?tgt?gca?cgt?att?gaa?gtc?gac?ggt?atg?cgc?gct 835

Gln?Ile?Ala?Trp?Leu?Cys?Ala?Arg?Ile?Glu?Val?Asp?Gly?Met?Arg?Ala

230 235 240 245

gac?ctg?gtg?atc?acg?cgt?acc?gca?ctt?gct?cac?gcc?gcg?tgg?gct?gga 883

Asp?Leu?Val?Ile?Thr?Arg?Thr?Ala?Leu?Ala?His?Ala?Ala?Trp?Ala?Gly

250 255 260

cgc?act?gtg?gtt?acg?gaa?gaa?gac?gtg?gag?atc?gca?gct?cgc?cta?gcg 931

Arg?Thr?Val?Val?Thr?Glu?Glu?Asp?Val?Glu?Ile?Ala?Ala?Arg?Leu?Ala

265 270 275

ttg?ccg?cac?cgc?cgt?cgc?cgt?aat?cct?ttc?gat?gct?cca?gaa?atg?gag 979

Leu?Pro?His?Arg?Arg?Arg?Arg?Asn?Pro?Phe?Asp?Ala?Pro?Glu?Met?Glu

280 285 290

gag?cgc?aag?ctt?cag?gaa?acc?ctg?cag?gaa?gct?cgg?gac?ttc?ttc?aaa 1027

Glu?Arg?Lys?Leu?Gln?Glu?Thr?Leu?Gln?Glu?Ala?Arg?Asp?Phe?Phe?Lys

295 300 305

gac?aat?gaa?gat?aaa?gga?cct?gcc?gcc?aag?atc?acc?gat?gag?gaa?acc 1075

Asp?Asn?Glu?Asp?Lys?Gly?Pro?Ala?Ala?Lys?Ile?Thr?Asp?Glu?Glu?Thr

310 315 320 325

ggt?gca?gag?gcc?ttt?acc?gat?acc?gac?aat?ccc?acc?gag?gaa?gac?ggt 1123

Gly?Ala?Glu?Ala?Phe?Thr?Asp?Thr?Asp?Asn?Pro?Thr?Glu?Glu?Asp?Gly

330 335 340

ctg?caa?gga?act?gcg?cag?gcg?aag?gcg?cag?act?act?gga?aag?gta?ggt 1171

Leu?Gln?Gly?Thr?Ala?Gln?Ala?Lys?Ala?Gln?Thr?Thr?Gly?Lys?Val?Gly

345 350 355

act?gcc?gga?tcc?ggc?gac?ccc?ttt?cgc?tcc?taggcatttg?cgcctggcgt 1221

Thr?Ala?Gly?Ser?Gly?Asp?Pro?Phe?Arg?Ser

360 365

cca

1224

<210>366

<211>367

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>366

Met?Ala?Ser?Gln?Gln?Ile?Arg?Tyr?Pro?Phe?Ser?Ala?Val?Val?Gly?Gln

1 5 10 15

Asp?Glu?Leu?Arg?Leu?Ala?Leu?Ile?Leu?Thr?Ala?Ile?Ser?Pro?Arg?Ile

20 25 30

Gly?Gly?Val?Val?Ile?Arg?Gly?Glu?Lys?Gly?Thr?Ala?Lys?Thr?Thr?Thr

35 40 45

Val?Arg?Ala?Phe?Ala?Gly?Leu?Leu?Gly?Asp?Ala?Pro?Leu?Val?Asn?Leu

50 55 60

Pro?Leu?Gly?Ser?Thr?Glu?Asp?Arg?Val?Val?Gly?Ser?Leu?Asn?Met?Glu

65 70 75 80

Thr?Val?Leu?Thr?Thr?Gly?Arg?Ala?Glu?Tyr?Gln?Pro?Gly?Leu?Leu?Ala

85 90 95

Gln?Ala?Asp?Gly?Gly?Val?Leu?Tyr?Val?Asp?Glu?Val?Asn?Leu?Leu?Ala

100 105 110

Asp?His?Leu?Val?Asp?Ala?Leu?Leu?Asp?Ala?Ala?Ala?Ser?Gly?Arg?Val

115 120 125

Ser?Ile?Glu?Arg?Asp?Gly?Ile?Ser?His?Ser?Ser?Pro?Ala?Asn?Phe?Val

130 135 140

Leu?Val?Gly?Thr?Met?Asn?Pro?Glu?Glu?Gly?Glu?Leu?Arg?Pro?Gln?Leu

145 150 155 160

Leu?Asp?Arg?Phe?Gly?Leu?Ala?Val?Asp?Val?Ala?Ala?Ser?Thr?Asn?Pro

165 170 175

Glu?Val?Arg?Val?Glu?Ile?Ile?Arg?Arg?Arg?Leu?Asp?Phe?Glu?Asn?Ala

180 185 190

Pro?Glu?Gln?Phe?Met?Ala?Lys?Trp?Ala?Glu?Gln?Asp?Ala?Asp?Thr?Ser

195 200 205

Asn?Arg?Ile?Leu?Ala?Ala?Lys?Asp?Leu?Leu?Pro?Gly?Val?Glu?Leu?Pro

210 215 220

Asp?Leu?Ile?Leu?Ser?Gln?Ile?Ala?Trp?Leu?Cys?Ala?Arg?Ile?Glu?Val

225 230 235 240

Asp?Gly?Met?Arg?Ala?Asp?Leu?Val?Ile?Thr?Arg?Thr?Ala?Leu?Ala?His

245 250 255

Ala?Ala?Trp?Ala?Gly?Arg?Thr?Val?Val?Thr?Glu?Glu?Asp?Val?Glu?Ile

260 265 270

Ala?Ala?Arg?Leu?Ala?Leu?Pro?His?Arg?Arg?Arg?Arg?Asn?Pro?Phe?Asp

275 280 285

Ala?Pro?Glu?Met?Glu?Glu?Arg?Lys?Leu?Gln?Glu?Thr?Leu?Gln?Glu?Ala

290 295 300

Arg?Asp?Phe?Phe?Lys?Asp?Asn?Glu?Asp?Lys?Gly?Pro?Ala?Ala?Lys?Ile

305 310 315 320

Thr?Asp?Glu?Glu?Thr?Gly?Ala?Glu?Ala?Phe?Thr?Asp?Thr?Asp?Asn?Pro

325 330 335

Thr?Glu?Glu?Asp?Gly?Leu?Gln?Gly?Thr?Ala?Gln?Ala?Lys?Ala?Gln?Thr

340 345 350

Thr?Gly?Lys?Val?Gly?Thr?Ala?Gly?Ser?Gly?Asp?Pro?Phe?Arg?Ser

355 360 365

<210>367

<211>473

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(450)

<223>FRXA01849

<400>367

ctg?cct?ggt?gtg?gag?ctg?ccg?gat?ctg?atc?ttg?tcg?cag?att?gcg?tgg 48

Leu?Pro?Gly?Val?Glu?Leu?Pro?Asp?Leu?Ile?Leu?Ser?Gln?Ile?Ala?Trp

1 5 10 15

ttg?tgt?gca?cgt?att?gaa?gtc?gac?ggt?atg?cgc?gct?gac?ctg?gtg?atc 96

Leu?Cys?Ala?Arg?Ile?Glu?Val?Asp?Gly?Met?Arg?Ala?Asp?Leu?Val?Ile

20 25 30

acg?cgt?acc?gca?ctt?gct?cac?gcc?gcg?tgg?gct?gga?cgc?act?gtg?gtt 144

Thr?Arg?Thr?Ala?Leu?Ala?His?Ala?Ala?Trp?Ala?Gly?Arg?Thr?Val?Val

35 40 45

acg?gaa?gaa?gac?gtg?gag?atc?gca?gct?cgc?cta?gcg?ttg?ccg?cac?cgc 192

Thr?Glu?Glu?Asp?Val?Glu?Ile?Ala?Ala?Arg?Leu?Ala?Leu?Pro?His?Arg

50 55 60

cgt?cgc?cgt?aat?cct?ttc?gat?gct?cca?gaa?atg?gag?gag?cgc?aag?ctt 240

Arg?Arg?Arg?Asn?Pro?Phe?Asp?Ala?Pro?Glu?Met?Glu?Glu?Arg?Lys?Leu

65 70 75 80

cag?gaa?acc?ctg?cag?gaa?gct?cgg?gac?ttc?ttc?aaa?gac?aat?gaa?gat 288

Gln?Glu?Thr?Leu?Gln?Glu?Ala?Arg?Asp?Phe?Phe?Lys?Asp?Asn?Glu?Asp

85 90 95

aaa?gga?cct?gcc?gcc?aag?atc?acc?gat?gag?gaa?acc?ggt?gca?gag?gcc 336

Lys?Gly?Pro?Ala?Ala?Lys?Ile?Thr?Asp?Glu?Glu?Thr?Gly?Ala?Glu?Ala

100 105 110

ttt?acc?gat?acc?gac?aat?ccc?acc?gag?gaa?gac?ggt?ctg?caa?gga?act 384

Phe?Thr?Asp?Thr?Asp?Asn?Pro?Thr?Glu?Glu?Asp?Gly?Leu?Gln?Gly?Thr

115 120 125

gcg?cag?gcg?aag?gcg?cag?act?act?gga?aag?gta?ggt?act?gcc?gga?tcc 432

Ala?Gln?Ala?Lys?Ala?Gln?Thr?Thr?Gly?Lys?Val?Gly?Thr?Ala?Gly?Ser

130 135 140

ggc?gac?ccc?ttt?cgc?tcc?taggcatttg?cgcctggcgt?cca 473

Gly?Asp?Pro?Phe?Arg?Ser

145 150

<210>368

<211>150

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>368

Leu?Pro?Gly?Val?Glu?Leu?Pro?Asp?Leu?Ile?Leu?Ser?Gln?Ile?Ala?Trp

1 5 10 15

Leu?Cys?Ala?Arg?Ile?Glu?Val?Asp?Gly?Met?Arg?Ala?Asp?Leu?Val?Ile

20 25 30

Thr?Arg?Thr?Ala?Leu?Ala?His?Ala?Ala?Trp?Ala?Gly?Arg?Thr?Val?Val

35 40 45

Thr?Glu?Glu?Asp?Val?Glu?Ile?Ala?Ala?Arg?Leu?Ala?Leu?Pro?His?Arg

50 55 60

Arg?Arg?Arg?Asn?Pro?Phe?Asp?Ala?Pro?Glu?Met?Glu?Glu?Arg?Lys?Leu

65 70 75 80

Gln?Glu?Thr?Leu?Gln?Glu?Ala?Arg?Asp?Phe?Phe?Lys?Asp?Asn?Glu?Asp

85 90 95

Lys?Gly?Pro?Ala?Ala?Lys?Ile?Thr?Asp?Glu?Glu?Thr?Gly?Ala?Glu?Ala

100 105 110

Phe?Thr?Asp?Thr?Asp?Asn?Pro?Thr?Glu?Glu?Asp?Gly?Leu?Gln?Gly?Thr

115 120 125

Ala?Gln?Ala?Lys?Ala?Gln?Thr?Thr?Gly?Lys?Val?Gly?Thr?Ala?Gly?Ser

130 135 140

Gly?Asp?Pro?Phe?Arg?Ser

145 150

<210>369

<211>667

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(667)

<223>FRXA01691

<400>369

aaaaccttaa?gttgggtggt?taaacccact?aaggtctcac?tttatggatg?tgccaggtca?60

caccaaaaaa?tctcaagaaa?actcacatta?aaggacagta?atg?gcg?tca?caa?cag 115

Met?Ala?Ser?Gln?Gln

1 5

atc?cgc?tat?cca?ttc?tcc?gcg?gtt?gtg?gga?caa?gac?gag?ctt?cgg?ctt 163

Ile?Arg?Tyr?Pro?Phe?Ser?Ala?Val?Val?Gly?Gln?Asp?Glu?Leu?Arg?Leu

10 15 20

gcg?ttg?atc?ctc?act?gcg?att?tcc?cca?cgc?att?ggt?ggc?gtg?gtg?att 211

Ala?Leu?Ile?Leu?Thr?Ala?Ile?Ser?Pro?Arg?Ile?Gly?Gly?Val?Val?Ile

25 30 35

cga?ggt?gag?aag?ggt?aca?gcg?aaa?act?acc?act?gtg?cgt?gct?ttt?gct 259

Arg?Gly?Glu?Lys?Gly?Thr?Ala?Lys?Thr?Thr?Thr?Val?Arg?Ala?Phe?Ala

40 45 50

ggt?ctt?tta?ggt?gat?gcc?cct?ttg?gtg?aac?ttg?cct?ctc?gga?tcc?acg 307

Gly?Leu?Leu?Gly?Asp?Ala?Pro?Leu?Val?Asn?Leu?Pro?Leu?Gly?Ser?Thr

55 60 65

gag?gat?cgt?gtg?gtg?ggt?tcc?ctc?aac?atg?gaa?act?gtg?ttg?acc?acc 355

Glu?Asp?Arg?Val?Val?Gly?Ser?Leu?Asn?Met?Glu?Thr?Val?Leu?Thr?Thr

70 75 80 85

ggc?cgt?gcg?gaa?tat?cag?cca?ggt?ttg?ctc?gcg?cag?gct?gat?ggc?ggt 403

Gly?Arg?Ala?Glu?Tyr?Gln?Pro?Gly?Leu?Leu?Ala?Gln?Ala?Asp?Gly?Gly

90 95 100

gtg?ctg?tat?gtc?gat?gag?gtc?aac?ctc?ttg?gcg?gat?cac?ctg?gtg?gat 451

Val?Leu?Tyr?Val?Asp?Glu?Val?Asn?Leu?Leu?Ala?Asp?His?Leu?Val?Asp

105 110 115

gct?ctg?ctc?gat?gca?gct?gca?agc?ggt?cgc?gtc?agc?att?gag?cgt?gac 499

Ala?Leu?Leu?Asp?Ala?Ala?Ala?Ser?Gly?Arg?Val?Ser?Ile?Glu?Arg?Asp

120 125 130

ggt?att?tcg?cat?tct?tca?cca?gca?aac?ttt?gtg?ttg?gtg?ggc?acc?atg 547

Gly?Ile?Ser?His?Ser?Ser?Pro?Ala?Asn?Phe?Val?Leu?Val?Gly?Thr?Met

135 140 145

aat?ccg?gag?gaa?ggc?gag?ctg?cgc?ccg?cag?ctg?ctg?gac?cgt?ttc?ggt 595

Asn?Pro?Glu?Glu?Gly?Glu?Leu?Arg?Pro?Gln?Leu?Leu?Asp?Arg?Phe?Gly

150 155 160 165

ttg?gct?gtg?gac?gtt?gct?gcg?tct?acg?aac?cct?gag?gtg?cgc?gtg?gag 643

Leu?Ala?Val?Asp?Val?Ala?Ala?Ser?Thr?Asn?Pro?Glu?Val?Arg?Val?Glu

170 175 180

atc?att?cgc?cgc?cgg?ctt?gat?ttt 667

Ile?Ile?Arg?Arg?Arg?Leu?Asp?Phe

185

<210>370

<211>189

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>370

Met?Ala?Ser?Gln?Gln?Ile?Arg?Tyr?Pro?Phe?Ser?Ala?Val?Val?Gly?Gln

1 5 10 15

Asp?Glu?Leu?Arg?Leu?Ala?Leu?Ile?Leu?Thr?Ala?Ile?Ser?Pro?Arg?Ile

20 25 30

Gly?Gly?Val?Val?Ile?Arg?Gly?Glu?Lys?Gly?Thr?Ala?Lys?Thr?Thr?Thr

35 40 45

Val?Arg?Ala?Phe?Ala?Gly?Leu?Leu?Gly?Asp?Ala?Pro?Leu?Val?Asn?Leu

50 55 60

Pro?Leu?Gly?Ser?Thr?Glu?Asp?Arg?Val?Val?Gly?Ser?Leu?Asn?Met?Glu

65 70 75 80

Thr?Val?Leu?Thr?Thr?Gly?Arg?Ala?Glu?Tyr?Gln?Pro?Gly?Leu?Leu?Ala

85 90 95

Gln?Ala?Asp?Gly?Gly?Val?Leu?Tyr?Val?Asp?Glu?Val?Asn?Leu?Leu?Ala

100 105 110

Asp?His?Leu?Val?Asp?Ala?Leu?Leu?Asp?Ala?Ala?Ala?Ser?Gly?Arg?Val

115 120 125

Ser?Ile?Glu?Arg?Asp?Gly?Ile?Ser?His?Ser?Ser?Pro?Ala?Asn?Phe?Val

130 135 140

Leu?Val?Gly?Thr?Met?Asn?Pro?Glu?Glu?Gly?Glu?Leu?Arg?Pro?Gln?Leu

145 150 155 160

Leu?Asp?Arg?Phe?Gly?Leu?Ala?Val?Asp?Val?Ala?Ala?Ser?Thr?Asn?Pro

165 170 175

Glu?Val?Arg?Val?Glu?Ile?Ile?Arg?Arg?Arg?Leu?Asp?Phe

180 185

<210>371

<211>601

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(601)

<223>RXN00665

<400>371

accaaacact?tctgtgcgtg?acacgcgcca?cct?tatactc?ccacaagcaa?cacagaacac?60

tcgggatctc?aaagtttcga?gaaacacaga?aagggcagca?atg?agc?agc?tca?aca 115

Met?Ser?Ser?Ser?Thr

1 5

ctt?ctc?ctg?gct?tca?gga?caa?gtc?acg?gca?tta?gcc?gct?gac?tac?acg 163

Leu?Leu?Leu?Ala?Ser?Gly?Gln?Val?Thr?Ala?Leu?Ala?Ala?Asp?Tyr?Thr

10 15 20

ctc?agc?cac?acc?ccc?tca?gat?ggc?atc?ctg?gta?gtc?ctt?ggc?ttc?gcc 211

Leu?Ser?His?Thr?Pro?Ser?Asp?Gly?Ile?Leu?Val?Val?Leu?Gly?Phe?Ala

25 30 35

atg?atc?ctc?acc?ttc?atg?acc?ctg?atc?atg?ctg?ggt?cga?ctc?acc?cca 259

Met?Ile?Leu?Thr?Phe?Met?Thr?Leu?Ile?Met?Leu?Gly?Arg?Leu?Thr?Pro

40 45 50

atg?gtg?gcc?atg?ctg?ttg?gtc?ccc?acc?atc?ttc?ggt?ctc?atc?gcc?ggc 307

Met?Val?Ala?Met?Leu?Leu?Val?Pro?Thr?Ile?Phe?Gly?Leu?Ile?Ala?Gly

55 60 65

gca?gga?ctc?ggc?ctt?ggt?gac?atg?gcg?ctt?gac?gcc?atc?aag?gac?atg 355

Ala?Gly?Leu?Gly?Leu?Gly?Asp?Met?Ala?Leu?Asp?Ala?Ile?Lys?Asp?Met

70 75 80 85

gcg?cct?acc?gcg?gca?ctc?ctg?atg?ttc?gcg?att?atg?ttc?ttc?gga?atc 403

Ala?Pro?Thr?Ala?Ala?Leu?Leu?Met?Phe?Ala?Ile?Met?Phe?Phe?Gly?Ile

90 95 100

atg?atc?gac?gtc?gga?ctc?ttc?gac?ccc?ctg?atc?cgc?gtg?atc?acc?cgc 451

Met?Ile?Asp?Val?Gly?Leu?Phe?Asp?Pro?Leu?Ile?Arg?Val?Ile?Thr?Arg

105 110 115

gtt?ctt?cac?gat?gac?ccc?gca?aag?gtc?gtc?atc?ggc?acc?gca?gta?ctt 499

Val?Leu?His?Asp?Asp?Pro?Ala?Lys?Val?Val?Ile?Gly?Thr?Ala?Val?Leu

120 125 130

gca?ggt?gtt?gtc?tcc?ctc?gac?ggc?gac?ggc?tcc?acc?acc?ttc?atc?att 547

Ala?Gly?Val?Val?Ser?Leu?Asp?Gly?Asp?Gly?Ser?Thr?Thr?Phe?Ile?Ile

135 140 145

acc?acc?ttc?cgc?gat?gct?gcc?cat?cta?cct?gcg?cct?tgg?cat?gag?ccc 595

Thr?Thr?Phe?Arg?Asp?Ala?Ala?His?Leu?Pro?Ala?Pro?Trp?His?Glu?Pro

150 155 160 165

tgt ggt

Cys?Gly

<210>372

<211>167

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>372

Met?Ser?Ser?Ser?Thr?Leu?Leu?Leu?Ala?Ser?Gly?Gln?Val?Thr?Ala?Leu

1 5 10 15

Ala?Ala?Asp?Tyr?Thr?Leu?Ser?His?Thr?Pro?Ser?Asp?Gly?Ile?Leu?Val

20 25 30

Val?Leu?Gly?Phe?Ala?Met?Ile?Leu?Thr?Phe?Met?Thr?Leu?Ile?Met?Leu

35 40 45

Gly?Arg?Leu?Thr?Pro?Met?Val?Ala?Met?Leu?Leu?Val?Pro?Thr?Ile?Phe

50 55 60

Gly?Leu?Ile?Ala?Gly?Ala?Gly?Leu?Gly?Leu?Gly?Asp?Met?Ala?Leu?Asp

65 70 75 80

Ala?Ile?Lys?Asp?Met?Ala?Pro?Thr?Ala?Ala?Leu?Leu?Met?Phe?Ala?Ile

85 90 95

Met?Phe?Phe?Gly?Ile?Met?Ile?Asp?Val?Gly?Leu?Phe?Asp?Pro?Leu?Ile

100 105 110

Arg?Val?Ile?Thr?Arg?Val?Leu?His?Asp?Asp?Pro?Ala?Lys?Val?Val?Ile

115 120 125

Gly?Thr?Ala?Val?Leu?Ala?Gly?Val?Val?Ser?Leu?Asp?Gly?Asp?Gly?Ser

130 135 140

Thr?Thr?Phe?Ile?Ile?Thr?Thr?Phe?Arg?Asp?Ala?Ala?His?Leu?Pro?Ala

145 150 155 160

Pro?Trp?His?Glu?Pro?Cys?Gly

165

<210>373

<211>390

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(367)

<223>RXN03026

<400>373

gttggcggcg?cagtatcgtg?aggtgcggga?cctcgagcgg?ggaatcccaa?actagcatcc?60

cgaactagcc?ccccaacaac?aattagaaat?ggaacctaaa?atg?cct?gga?aaa?att 115

Met?Pro?Gly?Lys?Ile

1 5

ctc?ctt?ctc?aac?ggc?cca?aac?ctg?aac?atg?ctg?ggc?aaa?cgc?gag?cct 163

Leu?Leu?Leu?Asn?Gly?Pro?Asn?Leu?Asn?Met?Leu?Gly?Lys?Arg?Glu?Pro

10 15 20

gac?att?tac?gga?cac?gac?acc?ttg?gaa?gac?gtc?gtc?gcg?ctg?gca?acc 211

Asp?Ile?Tyr?Gly?His?Asp?Thr?Leu?Glu?Asp?Val?Val?Ala?Leu?Ala?Thr

25 30 35

gct?gag?gct?gcg?aaa?cac?ggc?ctt?gag?gtt?gag?gcg?ctg?cag?agc?aat 259

Ala?Glu?Ala?Ala?Lys?His?Gly?Leu?Glu?Val?Glu?Ala?Leu?Gln?Ser?Asn

40 45 50

cac?caa?ggt?gag?cta?atc?gat?gcg?ctg?cac?aac?gct?cgc?ggg?acc?cac 307

His?Gln?Gly?Glu?Leu?Ile?Asp?Ala?Leu?His?Asn?Ala?Arg?Gly?Thr?His

55 60 65

atc?ggt?tgc?gtg?att?aac?ccc?ggc?ggc?ctg?act?aca?ctt?cgg?tgg?cgc 355

Ile?Gly?Cys?Val?Ile?Asn?Pro?Gly?Gly?Leu?Thr?Thr?Leu?Arg?Trp?Arg

70 75 80 85

ttt?tgg?atg?ctg?tgaaggcgtc?tgagcttcct?acc 390

Phe?Trp?Met?Leu

<210>374

<2l1>89

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>374

Met?Pro?Gly?Lys?Ile?Leu?Leu?Leu?Asn?Gly?Pro?Asn?Leu?Asn?Met?Leu

1 5 10 15

Gly?Lys?Arg?Glu?Pro?Asp?Ile?Tyr?Gly?His?Asp?Thr?Leu?Glu?Asp?Val

20 25 30

Val?Ala?Leu?Ala?Thr?Ala?Glu?Ala?Ala?Lys?His?Gly?Leu?Glu?Val?Glu

35 40 45

Ala?Leu?Gln?Ser?Asn?His?Gln?Gly?Glu?Leu?Ile?Asp?Ala?Leu?His?Asn

50 55 60

Ala?Arg?Gly?Thr?His?Ile?Gly?Cys?Val?Ile?Asn?Pro?Gly?Gly?Leu?Thr

65 70 75 80

Thr?Leu?Arg?Trp?Arg?Phe?Trp?Met?Leu

85

<210>375

<211>384

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(361)

<223>RXN02908

<400>375

gccaacgagg?gttggtttac?cacctctgat?tcaggtgaac?tccacgacgg?gattctcacc?60

gtgactggtc?gcgtggatac?ccgtcattga?ttccggtgga?ttg?aag?ttg?cac?cca 115

Leu?Lys?Leu?His?Pro

1 5

gag?gta?ctg?gaa?cgt?gcc?atc?gca?gat?att?aaa?ggt?gtc?acc?gcg?gcg 163

Glu?Val?Leu?Glu?Arg?Ala?Ile?Ala?Asp?Ile?Lys?Gly?Val?Thr?Ala?Ala

10 15 20

tgt?gtt?gtg?ggt?att?ccc?gat?ccc?cga?tta?ggc?caa?gca?att?gtg?gcc 211

Cys?Val?Val?Gly?Ile?Pro?Asp?Pro?Arg?Leu?Gly?Gln?Ala?Ile?Val?Ala

25 30 35

gcg?tac?tcc?gga?tcg?atc?agt?ccg?tct?gaa?gtt?att?gaa?ggc?ctc?gac 259

Ala?Tyr?Ser?Gly?Ser?Ile?Ser?Pro?Ser?Glu?Val?Ile?Glu?Gly?Leu?Asp

40 45 50

gat?cta?cct?cgt?tgg?cag?ctt?ccc?aaa?cgg?ctg?aag?cat?ctg?gaa?tct 307

Asp?Leu?Pro?Arg?Trp?Gln?Leu?Pro?Lys?Arg?Leu?Lys?His?Leu?Glu?Ser

55 60 65

ttg?ccc?agc?att?ggt?cct?gga?aaa?gct?gat?cga?cgt?gct?atc?gcg?aag 355

Leu?Pro?Ser?Ile?Gly?Pro?Gly?Lys?Ala?Asp?Arg?Arg?Ala?Ile?Ala?Lys

70 75 80 85

ctg?ttt?tagtcttcat?tcttgctggc?tgc 384

Leu?Phe

<210>376

<211>87

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>376

Leu?Lys?Leu?His?Pro?Glu?Val?Leu?Glu?Arg?Ala?Ile?Ala?Asp?Ile?Lys

1 5 10 15

Gly?Val?Thr?Ala?Ala?Cys?Val?Val?Gly?Ile?Pro?Asp?Pro?Arg?Leu?Gly

20 25 30

Gln?Ala?Ile?Val?Ala?Ala?Tyr?Ser?Gly?Ser?Ile?Ser?Pro?Ser?Glu?Val

35 40 45

Ile?Glu?Gly?Leu?Asp?Asp?Leu?Pro?Arg?Trp?Gln?Leu?Pro?Lys?Arg?Leu

50 55 60

Lys?His?Leu?Glu?Ser?Leu?Pro?Ser?Ile?Gly?Pro?Gly?Lys?Ala?Asp?Arg

65 70 75 80

Arg?Ala?Ile?Ala?Lys?Leu?Phe

85

<210>377

<211>667

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(667)

<223>RXN03000

<400>377

cagcgtgttg?ctgcgcctgc?agaaaaccta?cagcgtcacc?cacaaagtcg?aaatccaagg?60

ctaaccccct?ttttcaactc?acagttagga?aacttcaccc?atg?tct?ctt?cca?cat 115

Met?Ser?Leu?Pro?His

1 5

tct?gat?gaa?ctc?cgc?ggc?caa?aag?atc?att?att?tcc?ggt?ggc?gga?att 163

Ser?Asp?Glu?Leu?Arg?Gly?Gln?Lys?Ile?Ile?Ile?Ser?Gly?Gly?Gly?Ile

10 15 20

ggt?ggc?gca?gca?ggt?gca?ctt?gcg?ctt?gct?ttg?cgc?ggt?gcc?gat?gtc 211

Gly?Gly?Ala?Ala?Gly?Ala?Leu?Ala?Leu?Ala?Leu?Arg?Gly?Ala?Asp?Val

25 30 35

act?ttg?tac?gaa?cgc?gca?gct?gag?ttc?aag?gag?gtc?ggc?gct?ggc?ctc 259

Thr?Leu?Tyr?Glu?Arg?Ala?Ala?Glu?Phe?Lys?Glu?Val?Gly?Ala?Gly?Leu

40 45 50

cag?atc?ggt?ccg?cac?ggc?tgg?cga?atg?ctg?gaa?tcc?tgg?ggt?ctg?ctc 307

Gln?Ile?Gly?Pro?His?Gly?Trp?Arg?Met?Leu?Glu?Ser?Trp?Gly?Leu?Leu

55 60 65

gac?caa?att?gtc?gtg?gcc?ggc?tac?ctc?cca?gaa?gac?atg?cag?ttc?cgc 355

Asp?Gln?Ile?Val?Val?Ala?Gly?Tyr?Leu?Pro?Glu?Asp?Met?Gln?Phe?Arg

70 75 80 85

gac?gct?gtc?aac?cgc?gaa?acc?atc?ctg?acc?atg?cgt?ttc?gat?gaa?gaa 403

Asp?Ala?Val?Asn?Arg?Glu?Thr?Ile?Leu?Thr?Met?Arg?Phe?Asp?Glu?Glu

90 95 100

ttc?cag?cag?cac?tac?ggc?ggt?cgc?tac?ctg?gtg?att?cac?cgc?tct?gac 451

Phe?Gln?Gln?His?Tyr?Gly?Gly?Arg?Tyr?Leu?Val?Ile?His?Arg?Ser?Asp

105 110 115

ctg?ctc?aac?atc?ctg?gtc?acc?aac?gcc?gaa?gca?gcg?ggc?gcg?aag?ctc 499

Leu?Leu?Asn?Ile?Leu?Val?Thr?Asn?Ala?Glu?Ala?Ala?Gly?Ala?Lys?Leu

120 125 130

cac?aat?ggc?gtc?ctg?gtc?acc?gat?tcc?cgc?acc?gtc?gac?ggc?ggt?atc 547

His?Asn?Gly?Val?Leu?Val?Thr?Asp?Ser?Arg?Thr?Val?Asp?Gly?Gly?Ile

135 140 145

gag?gtg?gac?atc?gaa?tcc?tcc?atc?aac?aag?ggc?gaa?gat?aac?aag?act 595

Glu?Val?Asp?Ile?Glu?Ser?Ser?Ile?Asn?Lys?Gly?Glu?Asp?Asn?Lys?Thr

150 155 160 165

ttg?ctt?gtc?gac?gcc?ttc?ctc?gcc?ttc?gac?ggc?atc?cac?tcg?gtc?atg 643

Leu?Leu?Val?Asp?Ala?Phe?Leu?Ala?Phe?Asp?Gly?Ile?His?Ser?Val?Met

170 175 180

cgc?aaa?aag?ctt?gtc?gac?gac?gcc 667

Arg?Lys?Lys?Leu?Val?Asp?Asp?Ala

185

<210>378

<211>189

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>378

Met?Ser?Leu?Pro?His?Ser?Asp?Glu?Leu?Arg?Gly?Gln?Lys?Ile?Ile?Ile

1 5 10 15

Ser?Gly?Gly?Gly?Ile?Gly?Gly?Ala?Ala?Gly?Ala?Leu?Ala?Leu?Ala?Leu

20 25 30

Arg?Gly?Ala?Asp?Val?Thr?Leu?Tyr?Glu?Arg?Ala?Ala?Glu?Phe?Lys?Glu

35 40 45

Val?Gly?Ala?Gly?Leu?Gln?Ile?Gly?Pro?His?Gly?Trp?Arg?Met?Leu?Glu

50 55 60

Ser?Trp?Gly?Leu?Leu?Asp?Gln?Ile?Val?Val?Ala?Gly?Tyr?Leu?Pro?Glu

65 70 75 80

Asp?Met?Gln?Phe?Arg?Asp?Ala?Val?Asn?Arg?Glu?Thr?Ile?Leu?Thr?Met

85 90 95

Arg?Phe?Asp?Glu?Glu?Phe?Gln?Gln?His?Tyr?Gly?Gly?Arg?Tyr?Leu?Val

100 105 110

Ile?His?Arg?Ser?Asp?Leu?Leu?Ash?Ile?Leu?Val?Thr?Asn?Ala?Glu?Ala

115 120 125

Ala?Gly?Ala?Lys?Leu?His?Asn?Gly?Val?Leu?Val?Thr?Asp?Ser?Arg?Thr

130 135 140

Val?Asp?Gly?Gly?Ile?Glu?Val?Asp?Ile?Glu?Ser?Ser?Ile?Asn?Lys?Gly

145 150 155 160

Glu?Asp?Asn?Lys?Thr?Leu?Leu?Val?Asp?Ala?Phe?Leu?Ala?Phe?Asp?Gly

165 170 175

Ile?His?Ser?Val?Met?Arg?Lys?Lys?Leu?Val?Asp?Asp?Ala

180 185

<210>379

<211>766

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(766)

<223>RXN03036

<400>379

tagaaaaatc?tacccagtaa?gcattcagga?accattcaga?atcttttctt?agcatgtctc?60

tatcagcgta?aacgtccgaa?catgaaaggc?tagaaaagcc?atg?gct?gag?cag?ttg 115

Met?Ala?Glu?Gln?Leu

1 5

cgt?caa?ttt?gaa?ggc?agg?gtc?ctc?cct?aat?caa?tcc?gag?gac?ttg?gaa 163

Arg?Gln?Phe?Glu?Gly?Arg?Val?Leu?Pro?Asn?Gln?Ser?Glu?Asp?Leu?Glu

10 15 20

gat?cag?ggt?ttg?gga?ttt?gac?ctg?gga?acc?gtt?ttc?tcc?cgc?agg?aag 211

Asp?Gln?Gly?Leu?Gly?Phe?Asp?Leu?Gly?Thr?Val?Phe?Ser?Arg?Arg?Lys

25 30 35

gtt?ttg?gga?ttc?atc?ggt?gtt?ggt?gga?gca?ggt?gtg?gca?ctt?gct?gct 259

Val?Leu?Gly?Phe?Ile?Gly?Val?Gly?Gly?Ala?Gly?Val?Ala?Leu?Ala?Ala

40 45 50

tgt?tca?cct?tct?ggt?tct?tcc?gcg?gca?tcg?agc?acc?tca?agc?gcg?tcc 307

Cys?Ser?Pro?Ser?Gly?Ser?Ser?Ala?Ala?Ser?Ser?Thr?Ser?Ser?Ala?Ser

55 60 65

agc?agc?gca?gct?gca?acc?acc?agt?gca?gca?gca?gag?act?ttg?act?gag 355

Ser?Ser?Ala?Ala?Ala?Thr?Thr?Ser?Ala?Ala?Ala?Glu?Thr?Leu?Thr?Glu

70 75 80 85

atg?aag?tcg?gag?act?gct?ggt?ccg?tac?ccg?ggc?gat?ggt?tcg?aat?ggt 403

Met?Lys?Ser?Glu?Thr?Ala?Gly?Pro?Tyr?Pro?Gly?Asp?Gly?Ser?Asn?Gly

90 95 100

ccg?gat?gtg?ttg?gag?gtc?tcc?ggt?gtg?gag?cgc?cag?gac?atc?acc?aag 451

Pro?Asp?Val?Leu?Glu?Val?Ser?Gly?Val?Glu?Arg?Gln?Asp?Ile?Thr?Lys

105 110 115

tcg?att?gat?tct?gac?acc?gtg?gca?gag?ggc?gta?cct?ctg?acg?ttg?act 499

Ser?Ile?Asp?Ser?Asp?Thr?Val?Ala?Glu?Gly?Val?Pro?Leu?Thr?Leu?Thr

120 125 130

atg?acc?att?ttg?gac?atg?aac?aac?aac?aat?cag?cca?atg?gag?ggt?gct 547

Met?Thr?Ile?Leu?Asp?Met?Asn?Asn?Asn?Asn?Gln?Pro?Met?Glu?Gly?Ala

135 140 145

gcg?gtg?tac?gtg?tgg?cac?tgt?gat?gcg?ccg?ggt?cga?tat?tcg?atg?tac 595

Ala?Val?Tyr?Val?Trp?His?Cys?Asp?Ala?Pro?Gly?Arg?Tyr?Ser?Met?Tyr

150 155 160 165

gac?tct?gag?ctg?gaa?gat?gag?acc?tat?tta?cgc?ggt?gtg?cag?att?acc 643

Asp?Ser?Glu?Leu?Glu?Asp?Glu?Thr?Tyr?Leu?Arg?Gly?Val?Gln?Ile?Thr

170 175 180

gat?aag?tat?ggc?cag?gtc?acg?ttc?gat?acc?att?ttc?cct?ggt?tgt?tat 691

Asp?Lys?Tyr?Gly?Gln?Val?Thr?Phe?Asp?Thr?Ile?Phe?Pro?Gly?Cys?Tyr

185 190 195

gcg?ggc?cgt?tgg?gtg?cat?att?cat?ttc?gag?gtg?ttc?ccg?gat?cga?gac 739

Ala?Gly?Arg?Trp?Val?His?Ile?His?Phe?Glu?Val?Phe?Pro?Asp?Arg?Asp

200 205 210

agc?atc?acg?gat?tcc?acg?aac?aac?att 766

Ser?Ile?Thr?Asp?Ser?Thr?Asn?Asn?Ile

215 220

<210>380

<211>222

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>380

Met?Ala?Glu?Gln?Leu?Arg?Gln?Phe?Glu?Gly?Arg?Val?Leu?Pro?Asn?Gln

1 5 10 15

Ser?Glu?Asp?Leu?Glu?Asp?Gln?Gly?Leu?Gly?Phe?Asp?Leu?Gly?Thr?Val

20 25 30

Phe?Ser?Arg?Arg?Lys?Val?Leu?Gly?Phe?Ile?Gly?Val?Gly?Gly?Ala?Gly

35 40 45

Val?Ala?Leu?Ala?Ala?Cys?Ser?Pro?Ser?Gly?Ser?Ser?Ala?Ala?Ser?Ser

50 55 60

Thr?Ser?Ser?Ala?Ser?Ser?Ser?Ala?Ala?Ala?Thr?Thr?Ser?Ala?Ala?Ala

65 70 75 80

Glu?Thr?Leu?Thr?Glu?Met?Lys?Ser?Glu?Thr?Ala?Gly?Pro?Tyr?Pro?Gly

85 90 95

Asp?Gly?Ser?Asn?Gly?Pro?Asp?Val?Leu?Glu?Val?Ser?Gly?Val?Glu?Arg

100 105 110

Gln?Asp?Ile?Thr?Lys?Ser?Ile?Asp?Ser?Asp?Thr?Val?Ala?Glu?Gly?Val

115 120 125

Pro?Leu?Thr?Leu?Thr?Met?Thr?Ile?Leu?Asp?Met?Asn?Asn?Asn?Asn?Gln

130 135 140

Pro?Met?Glu?Gly?Ala?Ala?Val?Tyr?Val?Trp?His?Cys?Asp?Ala?Pro?Gly

145 150 155 160

Arg?Tyr?Ser?Met?Tyr?Asp?Ser?Glu?Leu?Glu?Asp?Glu?Thr?Tyr?Leu?Arg

165 170 175

Gly?Val?Gln?Ile?Thr?Asp?Lys?Tyr?Gly?Gln?Val?Thr?Phe?Asp?Thr?Ile

180 185 190

Phe?Pro?Gly?Cys?Tyr?Ala?Gly?Arg?Trp?Val?His?Ile?His?Phe?Glu?Val

195 200 205

Phe?Pro?Asp?Arg?Asp?Ser?Ile?Thr?Asp?Ser?Thr?Asn?Asn?Ile

210 215 220

<210>381

<211>318

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(295)

<223>RXN02974

<400>381

gcaggcatgg?acacattcca?ggtcctgacc?ggcgtcagcg?gctactacga?tttggtgcgc?60

gccattccca?gagcagcgcc?ccacctatat?cgccacctcg?atg?cag?gat?ctc?tac 115

Met?Gln?Asp?Leu?Tyr

1 5

agc?gat?ccg?ggc?gag?ctc?aag?cca?ggt?gcc?cag?ggc?ggt?ttt?tca?gcg 163

Ser?Asp?Pro?Gly?Glu?Leu?Lys?Pro?Gly?Ala?Gln?Gly?Gly?Phe?Ser?Ala

10 15 20

ctt?atc?gac?ggc?gac?acc?ctg?gtc?att?tcc?ggc?ggc?gat?gcc?ggc?gca 211

Leu?Ile?Asp?Gly?Asp?Thr?Leu?Val?Ile?Ser?Gly?Gly?Asp?Ala?Gly?Ala

25 30 35

act?ccg?gtt?gca?gca?ctc?cgc?act?gcg?ttg?gat?gtg?gcc?tgg?gcg?gcc 259

Thr?Pro?Val?Ala?Ala?Leu?Arg?Thr?Ala?Leu?Asp?Val?Ala?Trp?Ala?Ala

40 45 50

aca?gag?cag?tca?ccg?agg?tac?gcg?ctg?att?cag?agg?tagctgctac 305

Thr?Glu?Gln?Ser?Pro?Arg?Tyr?Ala?Leu?Ile?Gln?Arg

55 60 65

tgcattgcag?agc 318

<210>382

<211>65

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>382

Met?Gln?Asp?Leu?Tyr?Ser?Asp?Pro?Gly?Glu?Leu?Lys?Pro?Gly?Ala?Gln

1 5 10 15

Gly?Gly?Phe?Ser?Ala?Leu?Ile?Asp?Gly?Asp?Thr?Leu?Val?Ile?Ser?Gly

20 25 30

Gly?Asp?Ala?Gly?Ala?Thr?Pro?Val?Ala?Ala?Leu?Arg?Thr?Ala?Leu?Asp

35 40 45

Val?Ala?Trp?Ala?Ala?Thr?Glu?Gln?Ser?Pro?Arg?Tyr?Ala?Leu?Ile?Gln

50 55 60

Arg

65

<210>383

<211>1017

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(994)

<223>RXN00393

<400>383

tctattcatt?tcacaatagc?gtttcacact?cccccatagc?ctgccgaacg?tatttcaagc?60

aattgcgcga?tcgagtatgt?gatggggaaa?gatagaggtt?atg?tct?cac?acg?gaa 115

Met?Ser?His?Thr?Glu

1 5

ccc?cag?ccg?aat?tct?gta?act?ttg?tcc?gat?tgg?att?caa?ggc?gca?cgc 163

Pro?Gln?Pro?Asn?Ser?Val?Thr?Leu?Ser?Asp?Trp?Ile?Gln?Gly?Ala?Arg

10 15 20

ccg?cgt?acc?tgg?gca?aat?gcg?ttc?gcg?cct?gtc?att?gcc?ggt?tca?ggt 211

Pro?Arg?Thr?Trp?Ala?Asn?Ala?Phe?Ala?Pro?Val?Ile?Ala?Gly?Ser?Gly

25 30 35

gtc?gcc?gct?ttt?cat?gat?ggt?ttt?gtg?tgg?tgg?aag?gcc?ttg?ctg?gcg 259

Val?Ala?Ala?Phe?His?Asp?Gly?Phe?Val?Trp?Trp?Lys?Ala?Leu?Leu?Ala

40 45 50

cvtt?gtc?gtg?gcg?tgg?gct?ttg?atc?atc?ggt?gtg?aat?tac?gcc?aat?gat 307

Leu?Val?Val?Ala?Trp?Ala?Leu?Ile?Ile?Gly?Val?Asn?Tyr?Ala?Asn?Asp

55 60 65

tac?tct?gat?ggc?att?cgt?ggc?acc?gat?gaa?gac?cgc?acc?ggt?cct?ctg 355

Tyr?Ser?Asp?Gly?Ile?Arg?Gly?Thr?Asp?Glu?Asp?Arg?Thr?Gly?Pro?Leu

70 75 80 85

cga?ctc?act?ggt?tct?ggg?ttg?gct?gag?ccg?aag?aaa?gtg?aaa?gct?gcg 403

Arg?Leu?Thr?Gly?Ser?Gly?Leu?Ala?Glu?Pro?Lys?Lys?Val?Lys?Ala?Ala

90 95 100

gcg?ttt?att?tct?ttc?ggt?atc?gca?ggt?gtc?gcc?ggc?acc?gcg?ctg?agc 451

Ala?Phe?Ile?Ser?Phe?Gly?Ile?Ala?Gly?Val?Ala?Gly?Thr?Ala?Leu?Ser

105 110 115

ctg?ttg?agc?gcg?tgg?tgg?ctg?atc?ctc?atc?ggc?atc?ctg?tgt?gtg?ctg 499

Leu?Leu?Ser?Ala?Trp?Trp?Leu?Ile?Leu?Ile?Gly?Ile?Leu?Cys?Val?Leu

120 125 130

ggc?gcg?tgg?ttc?tac?acc?ggc?ggt?aaa?aat?cct?tat?ggt?tac?cgc?ggg 547

Gly?Ala?Trp?Phe?Tyr?Thr?Gly?Gly?Lys?Asn?Pro?Tyr?Gly?Tyr?Arg?Gly

135 140 145

ctc?ggc?gag?att?gct?gtg?ttc?atc?ttc?ttc?ggc?ctc?gtc?gcg?gtc?atg 595

Leu?Gly?Glu?Ile?Ala?Val?Phe?Ile?Phe?Phe?Gly?Leu?Val?Ala?Val?Met

150 155 160 165

gga?acg?cag?ttc?acc?caa?acc?ggt?tcc?gtc?agc?tgg?gcc?ggt?ttg?gcc 643

Gly?Thr?Gln?Phe?Thr?Gln?Thr?Gly?Ser?Val?Ser?Trp?Ala?Gly?Leu?Ala

170 175 180

gcc?gca?gtt?ggc?gtg?ggg?tcg?atg?tct?gct?ggc?gtg?aac?ttg?gcc?aac 691

Ala?Ala?Val?Gly?Val?Gly?Ser?Met?Ser?Ala?Gly?Val?Asn?Leu?Ala?Asn

185 190 195

aat?att?cgc?gat?att?cca?acc?gat?agc?aag?acc?gga?aaa?att?acc?ctc 739

Asn?Ile?Arg?Asp?Ile?Pro?Thr?Asp?Ser?Lys?Thr?Gly?Lys?Ile?Thr?Leu

200 205 210

gcg?gtc?cgc?ctg?ggc?gat?gcg?ggt?gct?cgt?aag?ctg?ttc?ctc?gcg?ctg 787

Ala?Val?Arg?Leu?Gly?Asp?Ala?Gly?Ala?Arg?Lys?Leu?Phe?Leu?Ala?Leu

215 220 225

att?tcc?acg?ccg?ttc?atc?atg?tcc?atc?tgc?ctg?gcg?ttt?gtc?gcc?tgg 835

Ile?Ser?Thr?Pro?Phe?Ile?Met?Ser?Ile?Cys?Leu?Ala?Phe?Val?Ala?Trp

230 235 240 245

cca?gcg?ctg?atc?gcg?atc?atc?gtt?ttc?ccg?ctg?gca?ctg?aaa?gcc?gca 883

Pro?Ala?Leu?Ile?Ala?Ile?Ile?Val?Phe?Pro?Leu?Ala?Leu?Lys?Ala?Ala

250 255 260

ggg?ccg?atc?cgc?aac?aac?gcc?acc?ggc?aag?gat?ctc?atc?ccc?gtc?atc 931

Gly?Pro?Ile?Arg?Asn?Asn?Ala?Thr?Gly?Lys?Asp?Leu?Ile?Pro?Val?Ile

265 270 275

ggc?tca?aca?ggg?cgc?gcc?atg?gcg?ttg?tgg?gcc?gtg?ctc?acg?ggc?ctg 979

Gly?Ser?Thr?Gly?Arg?Ala?Met?Ala?Leu?Trp?Ala?Val?Leu?Thr?Gly?Leu

280 285 290

gca?tta?gcg?ttt?agc?taaaacgctt?ttcgacgctc?ccc 1017

Ala?Leu?Ala?Phe?Ser

295

<210>384

<211>298

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>384

Met?Ser?His?Thr?Glu?Pro?Gln?Pro?Asn?Ser?Val?Thr?Leu?Ser?Asp?Trp

1 5 10 15

Ile?Gln?Gly?Ala?Arg?Pro?Arg?Thr?Trp?Ala?Asn?Ala?Phe?Ala?Pro?Val

20 25 30

Ile?Ala?Gly?Ser?Gly?Val?Ala?Ala?Phe?His?Asp?Gly?Phe?Val?Trp?Trp

35 40 45

Lys?Ala?Leu?Leu?Ala?Leu?Val?Val?Ala?Trp?Ala?Leu?Ile?Ile?Gly?Val

50 55 60

Asn?Tyr?Ala?Asn?Asp?Tyr?Ser?Asp?Gly?Ile?Arg?Gly?Thr?Asp?Glu?Asp

65 70 75 80

Arg?Thr?Gly?Pro?Leu?Arg?Leu?Thr?Gly?Ser?Gly?Leu?Ala?Glu?Pro?Lys

85 90 95

Lys?Val?Lys?Ala?Ala?Ala?Phe?Ile?Ser?Phe?Gly?Ile?Ala?Gly?Val?Ala

100 105 110

Gly?Thr?Ala?Leu?Ser?Leu?Leu?Ser?Ala?Trp?Trp?Leu?Ile?Leu?Ile?Gly

115 120 125

Ile?Leu?Cys?Val?Leu?Gly?Ala?Trp?Phe?Tyr?Thr?Gly?Gly?Lys?Asn?Pro

130 135 140

Tyr?Gly?Tyr?Arg?Gly?Leu?Gly?Glu?Ile?Ala?Val?Phe?Ile?Phe?Phe?Gly

145 150 155 160

Leu?Val?Ala?Val?Met?Gly?Thr?Gln?Phe?Thr?Gln?Thr?Gly?Ser?Val?Ser

165 170 175

Trp?Ala?Gly?Leu?Ala?Ala?Ala?Val?Gly?Val?Gly?Ser?Met?Ser?Ala?Gly

180 185 190

Val?Asn?Leu?Ala?Asn?Asn?Ile?Arg?Asp?Ile?Pro?Thr?Asp?Ser?Lys?Thr

195 200 205

Gly?Lys?Ile?Thr?Leu?Ala?Val?Arg?Leu?Gly?Asp?Ala?Gly?Ala?Arg?Lys

210 215 220

Leu?Phe?Leu?Ala?Leu?Ile?Ser?Thr?Pro?Phe?Ile?Met?Ser?Ile?Cys?Leu

225 230 235 240

Ala?Phe?Val?Ala?Trp?Pro?Ala?Leu?Ile?Ala?Ile?Ile?Val?Phe?Pro?Leu

245 250 255

Ala?Leu?Lys?Ala?Ala?Gly?Pro?Ile?Arg?Asn?Asn?Ala?Thr?Gly?Lys?Asp

260 265 270

Leu?Ile?Pro?Val?Ile?Gly?Ser?Thr?Gly?Arg?Ala?Met?Ala?Leu?Trp?Ala

275 280 285

Val?Leu?Thr?Gly?Leu?Ala?Leu?Ala?Phe?Ser

290 295

<210>385

<211>1242

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1219)

<223>RXN00948

<400>385

acaccctcca?aatgatctcg?taaaacagta?ttgaatttag?gtacgactct?aatcgtacct?60

tgccctcaag?ccaagctagt?tgtacgatca?aactcgttgt?atg?gca?aac?gtc?gta 115

Met?Ala?Asn?Val?Val

1 5

cta?gtc?gat?cga?atg?gag?cct?ttg?gtg?tcc?aag?ctg?ttt?acc?cca?att 163

Leu?Val?Asp?Arg?Met?Glu?Pro?Leu?Val?Ser?Lys?Leu?Phe?Thr?Pro?Ile

10 15 20

caa?atc?cgc?gac?atc?acc?atc?ccc?aac?cgc?gtg?tgg?atg?tca?ccg?atg 211

Gln?Ile?Arg?Asp?Ile?Thr?Ile?Pro?Asn?Arg?Val?Trp?Met?Ser?Pro?Met

25 30 35

tgc?acc?tac?tct?gca?gcc?acc?ggt?tca?ggt?ctt?ccc?acc?gat?ttt?cac 259

Cys?Thr?Tyr?Ser?Ala?Ala?Thr?Gly?Ser?Gly?Leu?Pro?Thr?Asp?Phe?His

40 45 50

cag?gct?cat?tac?gca?gct?cgc?gca?gca?ggt?ggt?gtc?gga?tta?gtc?atg 307

Gln?Ala?His?Tyr?Ala?Ala?Arg?Ala?Ala?Gly?Gly?Val?Gly?Leu?Val?Met

55 60 65

gtt?gaa?gca?act?gga?gtg?aac?ccc?gta?gct?ccc?atc?tcc?cca?gtc?gac 355

Val?Glu?Ala?Thr?Gly?Val?Asn?Pro?Val?Ala?Pro?Ile?Ser?Pro?Val?Asp

70 75 80 85

ctt?gga?ctt?tgg?agc?cat?gac?caa?att?gaa?cca?ttc?tcc?cga?gtg?aca 403

Leu?Gly?Leu?Trp?Ser?His?Asp?Gln?Ile?Glu?Pro?Phe?Ser?Arg?Val?Thr

90 95 100

gca?gct?att?cgc?gcc?ggt?ggg?gca?gta?ccg?gcc?gtt?caa?tta?gcc?cat 451

Ala?Ala?Ile?Arg?Ala?Gly?Gly?Ala?Val?Pro?Ala?Val?Gln?Leu?Ala?His

105 110 115

gct?ggc?cgc?aag?gca?tcc?acc?gat?gct?ccg?tgg?aat?ggt?ggc?gga?tat 499

Ala?Gly?Arg?Lys?Ala?Ser?Thr?Asp?Ala?Pro?Trp?Asn?Gly?Gly?Gly?Tyr

120 125 130

gtt?gga?cca?gaa?acc?aat?gga?tgg?gag?act?gtc?ggc?ccc?agc?cct?ctg 547

Val?Gly?Pro?Glu?Thr?Asn?Gly?Trp?Glu?Thr?Val?Gly?Pro?Ser?Pro?Leu

135 140 145

gca?ttc?cca?ggt?ttg?cct?gct?ccg?cgc?gag?ctg?acg?gtt?tca?gaa?atc 595

Ala?Phe?Pro?Gly?Leu?Pro?Ala?Pro?Arg?Glu?Leu?Thr?Val?Ser?Glu?Ile

150 155 160 165

caa?gag?gtt?gtg?cag?cag?ttc?gct?ggc?gcc?gcc?gtt?cgt?gcc?gat?cag 643

Gln?Glu?Val?Val?Gln?Gln?Phe?Ala?Gly?Ala?Ala?Val?Arg?Ala?Asp?Gln

170 175 180

gct?ggt?ttt?gat?gtc?gtg?gaa?att?cac?gca?gca?cac?ggc?tac?ctt?ttg 691

Ala?Gly?Phe?Asp?Val?Val?Glu?Ile?His?Ala?Ala?His?Gly?Tyr?Leu?Leu

185 190 195

cat?aac?ttc?ctt?tct?ccg?atc?tcc?aac?aag?cgc?acc?gat?tca?tac?ggc 739

His?Asn?Phe?Leu?Ser?Pro?Ile?Ser?Asn?Lys?Arg?Thr?Asp?Ser?Tyr?Gly

200 205 210

gga?tct?tta?gaa?aac?cgc?gct?cgc?atc?gtg?ctc?gaa?gtc?att?gat?gca 787

Gly?Ser?Leu?Glu?Asn?Arg?Ala?Arg?Ile?Val?Leu?Glu?Val?Ile?Asp?Ala

215 220 225

atc?cgc?gca?gtg?tgg?cca?gag?gaa?aag?cct?gta?ttc?atg?cgc?att?tcc 835

Ile?Arg?Ala?Val?Trp?Pro?Glu?Glu?Lys?Pro?Val?Phe?Met?Arg?Ile?Ser

230 235 240 245

acc?acc?gac?tgg?gtg?gag?gaa?aac?cca?cag?gat?gat?cgc?gag?tcc?tgg 883

Thr?Thr?Asp?Trp?Val?Glu?Glu?Asn?Pro?Gln?Asp?Asp?Arg?Glu?Ser?Trp

250 255 260

acg?ctg?agc?caa?agc?agg?cag?ctg?gct?ttg?tgg?gca?tcc?gag?cac?gga 931

Thr?Leu?Ser?Gln?Ser?Arg?Gln?Leu?Ala?Leu?Trp?Ala?Ser?Glu?His?Gly

265 270 275

gtt?gat?ttg?atc?gat?gcc?tct?tct?ggt?ggc?ctc?gac?atc?gtc?ccc?att 979

Val?Asp?Leu?Ile?Asp?Ala?Ser?Ser?Gly?Gly?Leu?Asp?Ile?Val?Pro?Ile

280 285 290

ccg?cat?gac?cgc?gat?tac?caa?acc?gcg?aag?gcc?gca?gat?ctt?cac?gca 1027

Pro?His?Asp?Arg?Asp?Tyr?Gln?Thr?Ala?Lys?Ala?Ala?Asp?Leu?His?Ala

295 300 305

agt?acc?gga?gtg?aca?gtc?gct?gct?gtg?ggg?cgc?att?gat?gac?gcc?caa 1075

Ser?Thr?Gly?Val?Thr?Val?Ala?Ala?Val?Gly?Arg?Ile?Asp?Asp?Ala?Gln

310 315 320 325

act?gcg?cac?aat?ttg?gtt?gat?tct?ggc?gat?gtc?aat?gca?gtt?ttc?ctc 1123

Thr?Ala?His?Asn?Leu?Val?Asp?Ser?Gly?Asp?Val?Asn?Ala?Val?Phe?Leu

330 335 340

ggc?cgt?cca?ctg?ctc?aag?gat?cct?tcc?tgg?gca?aac?caa?gca?gcc?ctc 1171

Gly?Arg?Pro?Leu?Leu?Lys?Asp?Pro?Ser?Trp?Ala?Asn?Gln?Ala?Ala?Leu

345 350 355

gca?cta?ggt?gcg?gaa?ccc?agg?tat?gtt?cac?caa?tac?gac?tac?gta?ctt 1219

Ala?Leu?Gly?Ala?Glu?Pro?Arg?Tyr?Val?His?Gln?Tyr?Asp?Tyr?Val?Leu

360 365 370

taaaggagag?ttgacatgaa?ggt 1242

<210>386

<211>373

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>386

Met?Ala?Asn?Val?Val?Leu?Val?Asp?Arg?Met?Glu?Pro?Leu?Val?Ser?Lys

1 5 10 15

Leu?Phe?Thr?Pro?Ile?Gln?Ile?Arg?Asp?Ile?Thr?Ile?Pro?Asn?Arg?Val

20 25 30

Trp?Met?Ser?Pro?Met?Cys?Thr?Tyr?Ser?Ala?Ala?Thr?Gly?Ser?Gly?Leu

35 40 45

Pro?Thr?Asp?Phe?His?Gln?Ala?His?Tyr?Ala?Ala?Arg?Ala?Ala?Gly?Gly

50 55 60

Val?Gly?Leu?Val?Met?Val?Glu?Ala?Thr?Gly?Val?Asn?Pro?Val?Ala?Pro

65 70 75 80

Ile?Ser?Pro?Val?Asp?Leu?Gly?Leu?Trp?Ser?His?Asp?Gln?Ile?Glu?Pro

85 90 95

Phe?Ser?Arg?Val?Thr?Ala?Ala?Ile?Arg?Ala?Gly?Gly?Ala?Val?Pro?Ala

100 105 110

Val?Gln?Leu?Ala?His?Ala?Gly?Arg?Lys?Ala?Ser?Thr?Asp?Ala?Pro?Trp

115 120 125

Asn?Gly?Gly?Gly?Tyr?Val?Gly?Pro?Glu?Thr?Asn?Gly?Trp?Glu?Thr?Val

130 135 140

Gly?Pro?Ser?Pro?Leu?Ala?Phe?Pro?Gly?Leu?Pro?Ala?Pro?Arg?Glu?Leu

145 150 155 160

Thr?Val?Ser?Glu?Ile?Gln?Glu?Val?Val?Gln?Gln?Phe?Ala?Gly?Ala?Ala

165 170 175

Val?Arg?Ala?Asp?Gln?Ala?Gly?Phe?Asp?Val?Val?Glu?Ile?His?Ala?Ala

180 185 190

His?Gly?Tyr?Leu?Leu?His?Asn?Phe?Leu?Ser?Pro?Ile?Ser?Asn?Lys?Arg

195 200 205

Thr?Asp?Ser?Tyr?Gly?Gly?Ser?Leu?Glu?Asn?Arg?Ala?Arg?Ile?Val?Leu

210 215 220

Glu?Val?Ile?Asp?Ala?Ile?Arg?Ala?Val?Trp?Pro?Glu?Glu?Lys?Pro?Val

225 230 235 240

Phe?Met?Arg?Ile?Ser?Thr?Thr?Asp?Trp?Val?Glu?Glu?Asn?Pro?Gln?Asp

245 250 255

Asp?Arg?Glu?Ser?Trp?Thr?Leu?Ser?Gln?Ser?Arg?Gln?Leu?Ala?Leu?Trp

260 265 270

Ala?Ser?Glu?His?Gly?Val?Asp?Leu?Ile?Asp?Ala?Ser?Ser?Gly?Gly?Leu

275 280 285

Asp?Ile?Val?Pro?Ile?Pro?His?Asp?Arg?Asp?Tyr?Gln?Thr?Ala?Lys?Ala

290 295 300

Ala?Asp?Leu?His?Ala?Ser?Thr?Gly?Val?Thr?Val?Ala?Ala?Val?Gly?Arg

305 310 315 320

Ile?Asp?Asp?Ala?Gln?Thr?Ala?His?Asn?Leu?Val?Asp?Ser?Gly?Asp?Val

325 330 335

Asn?Ala?Val?Phe?Leu?Gly?Arg?Pro?Leu?Leu?Lys?Asp?Pro?Ser?Trp?Ala

340 345 350

Asn?Gln?Ala?Ala?Leu?Ala?Leu?Gly?Ala?Glu?Pro?Arg?Tyr?Val?His?Gln

355 360 365

Tyr?Asp?Tyr?Val?Leu

370

<210>387

<211>873

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(850)

<223>RXN01923

<400>387

ccaaagtgaa?taccccgact?gcagcagcgc?aaaagttcaa?gtactttggg?atgcaaatct?60

agtagcacgt?cccatgtttc?tcacactctc?aggagctgac?atg?tct?gca?ctt?att 115

Met?Ser?Ala?Leu?Ile

1 5

aaa?ggt?tca?gga?cct?cat?cat?gtg?gtt?gtc?tta?aat?ggt?tgg?ttt?ggt 163

Lys?Gly?Ser?Gly?Pro?His?His?Val?Val?Val?Leu?Asn?Gly?Trp?Phe?Gly

10 15 20

cat?gct?gcg?ggc?tgg?gga?gct?ttc?gct?gac?tat?ctt?gac?ctc?ggc?aac 211

His?Ala?Ala?Gly?Trp?Gly?Ala?Phe?Ala?Asp?Tyr?Leu?Asp?Leu?Gly?Asn

25 30 35

tac?acc?tgg?cac?ttt?tgg?gat?tac?cga?ggt?tac?ggc?aac?aga?aaa?gac 259

Tyr?Thr?Trp?His?Phe?Trp?Asp?Tyr?Arg?Gly?Tyr?Gly?Asn?Arg?Lys?Asp

40 45 50

gac?gca?gga?gaa?ttt?act?ctg?gag?gaa?att?tca?gcg?gat?atc?gtt?gca 307

Asp?Ala?Gly?Glu?Phe?Thr?Leu?Glu?Glu?Ile?Ser?Ala?Asp?Ile?Val?Ala

55 60 65

tac?atc?gac?tcg?att?gag?gca?gaa?aag?gtt?tcc?atc?ctg?ggc?cat?tcc 355

Tyr?Ile?Asp?Ser?Ile?Glu?Ala?Glu?Lys?Val?Ser?Ile?Leu?Gly?His?Ser

70 75 80 85

atg?ggt?gga?gtg?ttc?atg?cag?aaa?gtc?ctt?gca?gac?agc?gcc?acc?ccc 403

Met?Gly?Gly?Val?Phe?Met?Gln?Lys?Val?Leu?Ala?Asp?Ser?Ala?Thr?Pro

90 95 100

atc?gct?tca?ctg?gtt?gga?att?tct?gcc?gtt?gct?gca?gct?gga?aca?cca 451

Ile?Ala?Ser?Leu?Val?Gly?Ile?Ser?Ala?Val?Ala?Ala?Ala?Gly?Thr?Pro

105 110 115

ttc?gat?gag?gat?tct?cgg?aag?ctt?ttc?acc?tca?gca?ggg?cac?aac?ccg 499

Phe?Asp?Glu?Asp?Ser?Arg?Lys?Leu?Phe?Thr?Ser?Ala?Gly?His?Asn?Pro

120 125 130

gac?tcg?agg?cga?gcc?atc?atc?gat?ttc?acc?tca?gga?tct?cgc?caa?cct 547

Asp?Ser?Arg?Arg?Ala?Ile?Ile?Asp?Phe?Thr?Ser?Gly?Ser?Arg?Gln?Pro

135 140 145

gcc?gcg?tgg?ttg?gat?gat?ctc?acc?gac?tcg?gcg?gtg?cag?aat?tcc?act 595

Ala?Ala?Trp?Leu?Asp?Asp?Leu?Thr?Asp?Ser?Ala?Val?Gln?Asn?Ser?Thr

150 155 160 165

cca?gag?gcc?gtt?gaa?aag?tac?ttt?ttt?gcg?tgg?gct?gat?tgt?aat?ttc 643

Pro?Glu?Ala?Val?Glu?Lys?Tyr?Phe?Phe?Ala?Trp?Ala?Asp?Cys?Asn?Phe

170 175 180

gca?gcg?gat?tta?ggc?acc?caa?gat?ttg?ccc?gtg?gac?att?ctc?acc?ggc 691

Ala?Ala?Asp?Leu?Gly?Thr?Gln?Asp?Leu?Pro?Val?Asp?Ile?Leu?Thr?Gly

185 190 195

gat?ctc?gac?ccc?gcg?gtc?act?aaa?act?gcc?gtg?gaa?tcc?gca?ttc?ggc 739

Asp?Leu?Asp?Pro?Ala?Val?Thr?Lys?Thr?Ala?Val?Glu?Ser?Ala?Phe?Gly

200 205 210

ccg?atc?tat?caa?aat?ctg?acc?gtt?gaa?gaa?ctc?cac?gat?gtc?gga?cac 787

Pro?Ile?Tyr?Gln?Asn?Leu?Thr?Val?Glu?Glu?Leu?His?Asp?Val?Gly?His

215 220 225

tac?gca?att?ttc?gag?cac?ccc?tta?ggc?ctt?gcc?gcc?agg?gtg?ctt?cga 835

Tyr?Ala?Ile?Phe?Glu?His?Pro?Leu?Gly?Leu?Ala?Ala?Arg?Val?Leu?Arg

230 235 240 245

ttt?ctc?gac?gcc?gtc?tagtacttcc?gcaaattcac?cgg 873

Phe?Leu?Asp?Ala?Val

250

<210>388

<211>250

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>388

Met?Ser?Ala?Leu?Ile?Lys?Gly?Ser?Gly?Pro?His?His?Val?Val?Val?Leu

1 5 10 15

Asn?Gly?Trp?Phe?Gly?His?Ala?Ala?Gly?Trp?Gly?Ala?Phe?Ala?Asp?Tyr

20 25 30

Leu?Asp?Leu?Gly?Asn?Tyr?Thr?Trp?His?Phe?Trp?Asp?Tyr?Arg?Gly?Tyr

35 40 45

Gly?Asn?Arg?Lys?Asp?Asp?Ala?Gly?Glu?Phe?Thr?Leu?Glu?Glu?Ile?Ser

50 55 60

Ala?Asp?Ile?Val?Ala?Tyr?Ile?Asp?Ser?Ile?Glu?Ala?Glu?Lys?Val?Ser

65 70 75 80

Ile?Leu?Gly?His?Ser?Met?Gly?Gly?Val?Phe?Met?Gln?Lys?Val?Leu?Ala

85 90 95

Asp?Ser?Ala?Thr?Pro?Ile?Ala?Ser?Leu?Val?Gly?Ile?Ser?Ala?Val?Ala

100 105 110

Ala?Ala?Gly?Thr?Pro?Phe?Asp?Glu?Asp?Ser?Arg?Lys?Leu?Phe?Thr?Ser

115 120 125

Ala?Gly?His?Asn?Pro?Asp?Ser?Arg?Arg?Ala?Ile?Ile?Asp?Phe?Thr?Ser

130 135 140

Gly?Ser?Arg?Gln?Pro?Ala?Ala?Trp?Leu?Asp?Asp?Leu?Thr?Asp?Ser?Ala

145 150 155 160

Val?Gln?Asn?Ser?Thr?Pro?Glu?Ala?Val?Glu?Lys?Tyr?Phe?Phe?Ala?Trp

165 170 175

Ala?Asp?Cys?Asn?Phe?Ala?Ala?Asp?Leu?Gly?Thr?Gln?Asp?Leu?Pro?Val

180 185 190

Asp?Ile?Leu?Thr?Gly?Asp?Leu?Asp?Pro?Ala?Val?Thr?Lys?Thr?Ala?Val

195 200 205

Glu?Ser?Ala?Phe?Gly?Pro?Ile?Tyr?Gln?Asn?Leu?Thr?Val?Glu?Glu?Leu

210 215 220

His?Asp?Val?Gly?His?Tyr?Ala?Ile?Phe?Glu?His?Pro?Leu?Gly?Leu?Ala

225 230 235 240

Ala?Arg?Val?Leu?Arg?Phe?Leu?Asp?Ala?Val

245 250

<210>389

<211>873

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(850)

<223>RXN00398

<400>389

tgagttcgcc?accatcagca?ccggcaccca?ccagcgcggt?gtggttaacc?gtgagaagtt?60

tgtctcccgt?ctgcctgaag?cacctaagga?aaactaaatc?atg?gcc?aag?ttg?ttt 115

Met?Ala?Lys?Leu?Phe

1 5

gat?tcc?cat?ttc?cat?atc?atc?gat?ccc?cag?cac?cca?ctg?atc?gaa?aac 163

Asp?Ser?His?Phe?His?Ile?Ile?Asp?Pro?Gln?His?Pro?Leu?Ile?Glu?Asn

10 15 20

aac?ggc?tac?ctc?ccc?gag?cct?ttc?acc?gtg?gag?gat?tac?act?gcg?cgt 211

Asn?Gly?Tyr?Leu?Pro?Glu?Pro?Phe?Thr?Val?Glu?Asp?Tyr?Thr?Ala?Arg

25 30 35

gtt?gaa?ggc?ctc?gaa?gtt?gct?gcc?gga?gcg?att?gtt?tcc?ggt?tct?ttc 259

Val?Glu?Gly?Leu?Glu?Val?Ala?Ala?Gly?Ala?Ile?Val?Ser?Gly?Ser?Phe

40 45 50

cag?gct?ttc?gac?cag?ggc?tac?ctc?aaa?gat?gct?ctc?gca?gtg?ctt?ggc 307

Gln?Ala?Phe?Asp?Gln?Gly?Tyr?Leu?Lys?Asp?Ala?Leu?Ala?Val?Leu?Gly

55 60 65

cca?ggc?tat?gtc?ggt?gtc?act?cag?atc?ccc?gca?gat?acc?tct?gat?cag 355

Pro?Gly?Tyr?Val?Gly?Val?Thr?Gln?Ile?Pro?Ala?Asp?Thr?Ser?Asp?Gln

70 75 80 85

gag?att?ctt?gat?ctg?gac?aaa?gct?ggc?gtg?aag?gct?gtg?cgt?tta?aac 403

Glu?Ile?Leu?Asp?Leu?Asp?Lys?Ala?Gly?Val?Lys?Ala?Val?Arg?Leu?Asn

90 95 100

ttg?aag?cgc?ggt?ggt?tcg?gca?ggt?ctt?gac?gat?ctc?gag?acc?ttg?gca 451

Leu?Lys?Arg?Gly?Gly?Ser?Ala?Gly?Leu?Asp?Asp?Leu?Glu?Thr?Leu?Ala

105 110 115

cgc?cga?gtc?cac?gac?cta?gcc?ggt?tgg?cac?acc?gaa?ctc?tat?gtg?gat 499

Arg?Arg?Val?His?Asp?Leu?Ala?Gly?Trp?His?Thr?Glu?Leu?Tyr?Val?Asp

120 125 130

gct?cgc?gaa?cta?gac?gag?ttg?gaa?tca?acc?ttg?gcc?tcc?ctc?cct?gct 547

Ala?Arg?Glu?Leu?Asp?Glu?Leu?Glu?Ser?Thr?Leu?Ala?Ser?Leu?Pro?Ala

135 140 145

gtc?agc?att?gat?cac?tta?ggg?ctc?cac?cgc?gat?gga?ctt?ccc?gca?ctt 595

Val?Ser?Ile?Asp?His?Leu?Gly?Leu?His?Arg?Asp?Gly?Leu?Pro?Ala?Leu

150 155 160 165

ctt?cgc?ttg?gta?gaa?aat?ggc?att?aaa?gtc?aaa?gca?acc?gga?ttc?gga 643

Leu?Arg?Leu?Val?Glu?Asn?Gly?Ile?Lys?Val?Lys?Ala?Thr?Gly?Phe?Gly

170 175 180

cgg?gta?gaa?cta?gat?cca?act?gaa?gtc?atc?cag?gca?atc?atg?gct?gtc 691

Arg?Val?Glu?Leu?Asp?Pro?Thr?Glu?Val?Ile?Gln?Ala?Ile?Met?Ala?Val

185 190 195

gat?ccc?act?gct?ttg?atg?atc?gga?act?gat?ctt?cca?tcc?acc?cgc?act 739

Asp?Pro?Thr?Ala?Leu?Met?Ile?Gly?Thr?Asp?Leu?Pro?Ser?Thr?Arg?Thr

200 205 210

aag?cga?cct?ttc?gaa?gac?gct?gac?cta?gat?ttg?atc?gct?gaa?acg?gtt 787

Lys?Arg?Pro?Phe?Glu?Asp?Ala?Asp?Leu?Asp?Leu?Ile?Ala?Glu?Thr?Val

215 220 225

ggc?gaa?gat?cat?gtc?gac?aac?gtc?ttc?tgg?aac?aac?gct?gca?gcg?ttc 835

Gly?Glu?Asp?His?Val?Asp?Asn?Val?Phe?Trp?Asn?Asn?Ala?Ala?Ala?Phe

230 235 240 245

tac?ctc?gga?gac?cag?tagttttaag?acccgaaatg?tct 873

Tyr?Leu?Gly?Asp?Gln

250

<210>390

<211>250

<2l2>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>390

Met?Ala?Lys?Leu?Phe?Asp?Ser?His?Phe?His?Ile?Ile?Asp?Pro?Gln?His

1 5 10 15

Pro?Leu?Ile?Glu?Asn?Asn?Gly?Tyr?Leu?Pro?Glu?Pro?Phe?Thr?Val?Glu

20 25 30

Asp?Tyr?Thr?Ala?Arg?Val?Glu?Gly?Leu?Glu?Val?Ala?Ala?Gly?Ala?Ile

35 40 45

Val?Ser?Gly?Ser?Phe?Gln?Ala?Phe?Asp?Gln?Gly?Tyr?Leu?Lys?Asp?Ala

50 55 60

Leu?Ala?Val?Leu?Gly?Pro?Gly?Tyr?Val?Gly?Val?Thr?Gln?Ile?Pro?Ala

65 70 75 80

Asp?Thr?Ser?Asp?Gln?Glu?Ile?Leu?Asp?Leu?Asp?Lys?Ala?Gly?Val?Lys

85 90 95

Ala?Val?Arg?Leu?Asn?Leu?Lys?Arg?Gly?Gly?Ser?Ala?Gly?Leu?Asp?Asp

100 105 110

Leu?Glu?Thr?Leu?Ala?Arg?Arg?Val?His?Asp?Leu?Ala?Gly?Trp?His?Thr

115 120 125

Glu?Leu?Tyr?Val?Asp?Ala?Arg?Glu?Leu?Asp?Glu?Leu?Glu?Ser?Thr?Leu

130 135 140

Ala?Ser?Leu?Pro?Ala?Val?Ser?Ile?Asp?His?Leu?Gly?Leu?His?Arg?Asp

145 150 155 160

Gly?Leu?Pro?Ala?Leu?Leu?Arg?Leu?Val?Glu?Asn?Gly?Ile?Lys?Val?Lys

165 170 175

Ala?Thr?Gly?Phe?Gly?Arg?Val?Glu?Leu?Asp?Pro?Thr?Glu?Val?Ile?Gln

180 185 190

Ala?Ile?Met?Ala?Val?Asp?Pro?Thr?Ala?Leu?Met?Ile?Gly?Thr?Asp?Leu

195 200 205

Pro?Ser?Thr?Arg?Thr?Lys?Arg?Pro?Phe?Glu?Asp?Ala?Asp?Leu?Asp?Leu

210 215 220

Ile?Ala?Glu?Thr?Val?Gly?Glu?Asp?His?Val?Asp?Asn?Val?Phe?Trp?Asn

225 230 235 240

Asn?Ala?Ala?Ala?Phe?Tyr?Leu?Gly?Asp?Gln

245 250

<210>391

<211>1108

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1099)

<223>RXN02813

<400>391

ggactctaaa?ttgacccgat?ctttatactc?cgaccttgct?ggtagtggag?aacacctcag?60

cagcctttcc?gacgagactt?tcctaaagaa?tcttcttgtc?gtg?gag?gcc?gct?ttg 115

Val?Glu?Ala?Ala?Leu

1 5

gcg?gtt?gca?gct?gcc?ccc?gag?cac?gca?gca?atg?gcg?aag?gcc?acc?att 163

Ala?Val?Ala?Ala?Ala?Pro?Glu?His?Ala?Ala?Met?Ala?Lys?Ala?Thr?Ile

10 15 20

gat?tct?tat?cag?ttg?gat?gtg?gag?gag?ctt?tcc?cgt?cgc?gca?gcc?gag 211

Asp?Ser?Tyr?Gln?Leu?Asp?Val?Glu?Glu?Leu?Ser?Arg?Arg?Ala?Ala?Glu

25 30 35

ggc?ggt?aat?ccg?ctc?att?ccg?ctg?gtc?act?gac?ctc?aag?gcc?atc?aat 259

Gly?Gly?Asn?Pro?Leu?Ile?Pro?Leu?Val?Thr?Asp?Leu?Lys?Ala?Ile?Asn

40 45 50

ccg?gca?ggc?atc?cac?att?ggc?gca?acg?agc?cag?gac?atc?att?gat?tct 307

Pro?Ala?Gly?Ile?His?Ile?Gly?Ala?Thr?Ser?Gln?Asp?Ile?Ile?Asp?Ser

55 60 65

gcg?tta?atg?ctg?tgc?atg?aag?gaa?ggg?gtg?ggg?gag?gtc?gtc?gac?aag 355

Ala?Leu?Met?Leu?Cys?Met?Lys?Glu?Gly?Val?Gly?Glu?Val?Val?Asp?Lys

70 75 80 85

ctt?aaa?aag?ctt?gcg?cga?gat?ttg?gcc?gag?ctc?acc?gcg?gag?cat?aaa 403

Leu?Lys?Lys?Leu?Ala?Arg?Asp?Leu?Ala?Glu?Leu?Thr?Ala?Glu?His?Lys

90 95 100

gca?acc?ccg?atc?atg?ggg?cgc?acg?ttg?ggg?cag?atc?gcg?acg?ccg?acg 451

Ala?Thr?Pro?Ile?Met?Gly?Arg?Thr?Leu?Gly?Gln?Ile?Ala?Thr?Pro?Thr

105 110 115

acg?ttc?ggc?gcg?ctg?acc?ggc?ggc?tgg?ctg?gtt?gcg?gtg?gac?aat?gcg 499

Thr?Phe?Gly?Ala?Leu?Thr?Gly?Gly?Trp?Leu?Val?Ala?Val?Asp?Asn?Ala

120 125 130

gca?cgc?gcc?ctg?gag?gcg?ctg?gag?ttt?ccg?gtg?tcg?tat?ggc?ggt?gcc 547

Ala?Arg?Ala?Leu?Glu?Ala?Leu?Glu?Phe?Pro?Val?Ser?Tyr?Gly?Gly?Ala

135 140 145

agc?gga?aat?atg?acg?gcg?gtg?cac?ccg?cgt?ggc?ttc?gag?att?cag?gcg 595

Ser?Gly?Asn?Met?Thr?Ala?Val?His?Pro?Arg?Gly?Phe?Glu?Ile?Gln?Ala

150 155 160 165

aag?ctg?gcc?gag?gag?ttg?ggc?ctt?ttt?gat?ccg?cag?tgg?gtg?tgg?cat 643

Lys?Leu?Ala?Glu?Glu?Leu?Gly?Leu?Phe?Asp?Pro?Gln?Trp?Val?Trp?His

170 175 180

tcc?gat?cgc?acg?ccg?atc?act?gcg?atc?gcg?tcg?gcg?ctg?gca?acg?gcc 691

Ser?Asp?Arg?Thr?Pro?Ile?Thr?Ala?Ile?Ala?Ser?Ala?Leu?Ala?Thr?Ala

185 190 195

gct?ggt?gtg?gta?cgc?aaa?att?gct?ggt?gac?gtg?gtg?ttt?tac?tca?caa 739

Ala?Gly?Val?Val?Arg?Lys?lle?Ala?Gly?Asp?Val?Val?Phe?Tyr?Ser?Gln

200 205 210

acc?gag?gtc?ggc?gag?ttg?cgg?gag?aaa?tcc?ccc?ggc?ggc?agc?tcc?gcg 787

Thr?Glu?Val?Gly?Glu?Leu?Arg?Glu?Lys?Ser?Pro?Gly?Gly?Ser?Ser?Ala

215 220 225

atg?ccc?cac?aaa?gcc?aat?ccg?gcc?gct?gcg?att?gcg?tgc?gac?ggt?tac 835

Met?Pro?His?Lys?Ala?Asn?Pro?Ala?Ala?Ala?Ile?Ala?Cys?Asp?Gly?Tyr

230 235 240 245

gcg?cgc?cgg?gca?cct?ggc?ctt?ctt?gca?acg?ctt?ttc?gac?gcc?ctc?gac 883

Ala?Arg?Arg?Ala?Pro?Gly?Leu?Leu?Ala?Thr?Leu?Phe?Asp?Ala?Leu?Asp

250 255 260

tgc?cgt?ttg?cag?cgc?ggc?acc?ggc?agc?tgg?cac?gcg?gag?tgg?gca?acg 931

Cys?Arg?Leu?Gln?Arg?Gly?Thr?Gly?Ser?Trp?His?Ala?Glu?Trp?Ala?Thr

265 270 275

ctg?cgc?gag?ttg?gct?gct?gtc?act?cac?tca?gca?gtg?agc?agg?gct?gca 979

Leu?Arg?Glu?Leu?Ala?Ala?Val?Thr?His?Ser?Ala?Val?Ser?Arg?Ala?Ala

280 285 290

acc?agc?atc?gat?ggc?atc?acc?gtc?aac?gtt?gat?gtg?atg?gca?agt?cgc 1027

Thr?Ser?Ile?Asp?Gly?Ile?Thr?Val?Asn?Val?Asp?Val?Met?Ala?Ser?Arg

295 300 305

gtc?aat?gga?cca?acc?ggg?cac?gcc?gaa?gat?ttg?gcg?gag?cgg?gca?cta 1075

Val?Asn?Gly?Pro?Thr?Gly?His?Ala?Glu?Asp?Leu?Ala?Glu?Arg?Ala?Leu

310 315 320 325

gaa?att?tat?gga?aaa?gga?cgc?agt?taatggatc 1108

Glu?Ile?Tyr?Gly?Lys?Gly?Arg?Ser

330

<210>392

<211>333

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>392

Val?Glu?Ala?Ala?Leu?Ala?Val?Ala?Ala?Ala?Pro?Glu?His?Ala?Ala?Met

1 5 10 15

Ala?Lys?Ala?Thr?Ile?Asp?Ser?Tyr?Gln?Leu?Asp?Val?Glu?Glu?Leu?Ser

20 25 30

Arg?Arg?Ala?Ala?Glu?Gly?Gly?Asn?Pro?Leu?Ile?Pro?Leu?Val?Thr?Asp

35 40 45

Leu?Lys?Ala?Ile?Asn?Pro?Ala?Gly?Ile?His?Ile?Gly?Ala?Thr?Ser?Gln

50 55 60

Asp?Ile?Ile?Asp?Ser?Ala?Leu?Met?Leu?Cys?Met?Lys?Glu?Gly?Val?Gly

65 70 75 80

Glu?Val?Val?Asp?Lys?Leu?Lys?Lys?Leu?Ala?Arg?Asp?Leu?Ala?Glu?Leu

85 90 95

Thr?Ala?Glu?His?Lys?Ala?Thr?Pro?Ile?Met?Gly?Arg?Thr?Leu?Gly?Gln

100 105 110

Ile?Ala?Thr?Pro?Thr?Thr?Phe?Gly?Ala?Leu?Thr?Gly?Gly?Trp?Leu?Val

115 120 125

Ala?Val?Asp?Asn?Ala?Ala?Arg?Ala?Leu?Glu?Ala?Leu?Glu?Phe?Pro?Val

130 135 140

Ser?Tyr?Gly?Gly?Ala?Ser?Gly?Asn?Met?Thr?Ala?Val?His?Pro?Arg?Gly

145 150 155 160

Phe?Glu?Ile?Gln?Ala?Lys?Leu?Ala?Glu?Glu?Leu?Gly?Leu?Phe?Asp?Pro

165 170 175

Gln?Trp?Val?Trp?His?Ser?Asp?Arg?Thr?Pro?Ile?Thr?Ala?Ile?Ala?Ser

180 185 190

Ala?Leu?Ala?Thr?Ala?Ala?Gly?Val?Val?Arg?Lys?Ile?Ala?Gly?Asp?Val

195 200 205

Val?Phe?Tyr?Ser?Gln?Thr?Glu?Val?Gly?Glu?Leu?Arg?Glu?Lys?Ser?Pro

210 215 220

Gly?Gly?Ser?Ser?Ala?Met?Pro?His?Lys?Ala?Asn?Pro?Ala?Ala?Ala?Ile

225 230 235 240

Ala?Cys?Asp?Gly?Tyr?Ala?Arg?Arg?Ala?Pro?Gly?Leu?Leu?Ala?Thr?Leu

245 250 255

Phe?Asp?Ala?Leu?Asp?Cys?Arg?Leu?Gln?Arg?Gly?Thr?Gly?Ser?Trp?His

260 265 270

Ala?Glu?Trp?Ala?Thr?Leu?Arg?Glu?Leu?Ala?Ala?Val?Thr?His?Ser?Ala

275 280 285

Val?Ser?Arg?Ala?Ala?Thr?Ser?Ile?Asp?Gly?Ile?Thr?Val?Asn?Val?Asp

290 295 300

Val?Met?Ala?Ser?Arg?Val?Asn?Gly?Pro?Thr?Gly?His?Ala?Glu?Asp?Leu

305 310 315 320

Ala?Glu?Arg?Ala?Leu?Glu?Ile?Tyr?Gly?Lys?Gly?Arg?Ser

325 330

<210>393

<211>1218

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1195)

<223>RXN00136

<400>393

cagtgttgca?tcatctagaa?atcgattaat?taaaccgggc?acctgattaa?cattgggctg?60

cccggtttct?tcctattaca?agcgaaaggc?aacgtgcccc?atg?agc?gca?gtg?cag 115

Met?Ser?Ala?Val?Gln

1 5

att?ttc?aac?acc?gtc?cac?gtc?aat?gga?tct?tcc?ccc?tat?gat?gtc?cac 163

Ile?Phe?Asn?Thr?Val?His?Val?Asn?Gly?Ser?Ser?Pro?Tyr?Asp?Val?His

10 15 20

att?ggt?tcc?ggc?ctc?aac?gag?ctc?att?gtt?cag?cgc?gca?gcg?gaa?tca 211

Ile?Gly?Ser?Gly?Leu?Asn?Glu?Leu?Ile?Val?Gln?Arg?Ala?Ala?Glu?Ser

25 30 35

ggc?gcg?gag?cag?gta?gcg?att?ttg?cac?cag?ccc?agc?atg?gat?gac?att 259

Gly?Ala?Glu?Gln?Val?Ala?Ile?Leu?His?Gln?Pro?Ser?Met?Asp?Asp?Ile

40 45 50

gca?tcc?gag?ttg?gat?gca?gca?cta?gtc?gct?gct?ggt?ttg?aag?gtc?ctg 307

Ala?Ser?Glu?Leu?Asp?Ala?Ala?Leu?Val?Ala?Ala?Gly?Leu?Lys?Val?Leu

55 60 65

cac?ctt?aat?gtt?ccc?gat?gcg?gaa?aac?ggc?aag?tcc?ttg?gaa?gta?gcg 355

His?Leu?Asn?Val?Pro?Asp?Ala?Glu?Asn?Gly?Lys?Ser?Leu?Glu?Val?Ala

70 75 80 85

ggg?cag?tgc?tgg?gat?gaa?ttg?ggt?ggc?gca?gca?ttc?ggc?cgc?cgc?gat 403

Gly?Gln?Cys?Trp?Asp?Glu?Leu?Gly?Gly?Ala?Ala?Phe?Gly?Arg?Arg?Asp

90 95 100

atc?gtc?atc?gga?ctt?ggt?ggc?ggt?gct?gcc?aca?gat?ctc?gcg?gga?ttc 451

Ile?Val?Ile?Gly?Leu?Gly?Gly?Gly?Ala?Ala?Thr?Asp?Leu?Ala?Gly?Phe

105 110 115

gtc?gct?gct?gca?tgg?atg?cgt?ggc?gtg?cgc?gtc?att?cag?gtt?cca?acc 499

Val?Ala?Ala?Ala?Trp?Met?Arg?Gly?Val?Arg?Val?Ile?Gln?Val?Pro?Thr

120 125 130

acc?ttg?ttg?gcc?atg?gtg?gac?gct?gcg?gtg?ggc?ggc?aag?act?ggc?atc 547

Thr?Leu?Leu?Ala?Met?Val?Asp?Ala?Ala?Val?Gly?Gly?Lys?Thr?Gly?Ile

135 140 145

aat?acc?gcc?gca?ggc?aag?aac?ctt?gtg?ggc?gcg?ttc?cac?gag?cct?gac 595

Asn?Thr?Ala?Ala?Gly?Lys?Asn?Leu?Val?Gly?Ala?Phe?His?Glu?Pro?Asp

150 155 160 165

gca?gta?ttc?att?gac?acc?gat?cgc?cta?gcc?acc?ctg?cct?gac?gcg?gaa 643

Ala?Val?Phe?Ile?Asp?Thr?Asp?Arg?Leu?Ala?Thr?Leu?Pro?Asp?Ala?Glu

170 175 180

atc?atc?gcg?gga?tcc?gcc?gaa?atc?atc?aaa?act?ggt?ttc?atc?gcc?gac 691

Ile?Ile?Ala?Gly?Ser?Ala?Glu?Ile?Ile?Lys?Thr?Gly?Phe?Ile?Ala?Asp

185 190 195

cca?gaa?atc?ctg?cgc?ctt?tac?gaa?act?gat?ccc?gca?gcc?tgc?ctg?aag 739

Pro?Glu?Ile?Leu?Arg?Leu?Tyr?Glu?Thr?Asp?Pro?Ala?Ala?Cys?Leu?Lys

200 205 210

aaa?gaa?gtc?gaa?ggc?tcc?cac?cta?cct?gaa?ctg?att?tgg?cgc?tcc?gtc 787

Lys?Glu?Val?Glu?Gly?Ser?His?Leu?Pro?Glu?Leu?Ile?Trp?Arg?Ser?Val

215 220 225

acc?gtc?aag?ggc?tcc?gtg?gtc?ggc?caa?gac?ctc?aaa?gaa?tct?agc?ctg 835

Thr?Val?Lys?Gly?Ser?Val?Val?Gly?Gln?Asp?Leu?Lys?Glu?Ser?Ser?Leu

230 235 240 245

cgc?gaa?atc?ctc?aac?tac?gga?cac?acc?ttt?gcc?cac?gcc?gtc?gaa?ctc 883

Arg?Glu?Ile?Leu?Asn?Tyr?Gly?His?Thr?Phe?Ala?His?Ala?Val?Glu?Leu

250 255 260

cgc?gaa?aac?ttc?cgc?tgg?cgc?cac?ggc?aat?gcc?gtt?gca?gtg?ggc?atg 931

Arg?Glu?Asn?Phe?Arg?Trp?Arg?His?Gly?Asn?Ala?Val?Ala?Val?Gly?Met

265 270 275

atg?ttc?atc?gcc?aac?ctc?tcc?cac?aag?ctc?ggg?ctt?atc?gac?gcg?ccc 979

Met?Phe?Ile?Ala?Asn?Leu?Ser?His?Lys?Leu?Gly?Leu?Ile?Asp?Ala?Pro

280 285 290

ctc?ctc?gag?cgc?cac?cgc?tca?atc?ctg?gcg?gcc?atc?ggt?ctg?ccc?act 1027

Leu?Leu?Glu?Arg?His?Arg?Ser?Ile?Leu?Ala?Ala?Ile?Gly?Leu?Pro?Thr

295 300 305

tcc?tac?gaa?ggc?gga?gcc?ttc?gac?gag?ctt?tac?gac?ggt?atg?acc?cgc 1075

Ser?Tyr?Glu?Gly?Gly?Ala?Phe?Asp?Glu?Leu?Tyr?Asp?Gly?Met?Thr?Arg

310 315 320 325

gac?aag?aaa?aac?cgc?gac?ggc?aac?atc?cgc?ttc?gtc?gca?ctg?acc?gcc 1123

Asp?Lys?Lys?Asn?Arg?Asp?Gly?Asn?Ile?Arg?Phe?Val?Ala?Leu?Thr?Ala

330 335 340

gtg?ggc?gag?gtt?acc?cgc?att?gag?ggg?ccc?tca?aaa?caa?gat?tta?cag 1171

Val?Gly?Glu?Val?Thr?Arg?Ile?Glu?Gly?Pro?Ser?Lys?Gln?Asp?Leu?Gln

345 350 355

agt?gct?tat?gag?gca?atc?agc?cac?taagtgttga?gtaatctact?agt 1218

Ser?Ala?Tyr?Glu?Ala?Ile?Ser?His

360 365

<210>394

<211>365

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>394

Met?Ser?Ala?Val?Gln?Ile?Phe?Asn?Thr?Val?His?Val?Asn?Gly?Ser?Ser

1 5 10 15

Pro?Tyr?Asp?Val?His?Ile?Gly?Ser?Gly?Leu?Asn?Glu?Leu?Ile?Val?Gln

20 25 30

Arg?Ala?Ala?Glu?Ser?Gly?Ala?Glu?Gln?Val?Ala?Ile?Leu?His?Gln?Pro

35 40 45

Ser?Met?Asp?Asp?Ile?Ala?Ser?Glu?Leu?Asp?Ala?Ala?Leu?Val?Ala?Ala

50 55 60

Gly?Leu?Lys?Val?Leu?His?Leu?Asn?Val?Pro?Asp?Ala?Glu?Asn?Gly?Lys

65 70 75 80

Ser?Leu?Glu?Val?Ala?Gly?Gln?Cys?Trp?Asp?Glu?Leu?Gly?Gly?Ala?Ala

85 90 95

Phe?Gly?Arg?Arg?Asp?Ile?Val?Ile?Gly?Leu?Gly?Gly?Gly?Ala?Ala?Thr

100 105 110

Asp?Leu?Ala?Gly?Phe?Val?Ala?Ala?Ala?Trp?Met?Arg?Gly?Val?Arg?Val

115 120 125

Ile?Gln?Val?Pro?Thr?Thr?Leu?Leu?Ala?Met?Val?Asp?Ala?Ala?Val?Gly

130 135 140

Gly?Lys?Thr?Gly?Ile?Asn?Thr?Ala?Ala?Gly?Lys?Asn?Leu?Val?Gly?Ala

145 150 155 160

Phe?His?Glu?Pro?Asp?Ala?Val?Phe?Ile?Asp?Thr?Asp?Arg?Leu?Ala?Thr

165 170 175

Leu?Pro?Asp?Ala?Glu?Ile?Ile?Ala?Gly?Ser?Ala?Glu?Ile?Ile?Lys?Thr

180 185 190

Gly?Phe?Ile?Ala?Asp?Pro?Glu?Ile?Leu?Arg?Leu?Tyr?Glu?Thr?Asp?Pro

195 200 205

Ala?Ala?Cys?Leu?Lys?Lys?Glu?Val?Glu?Gly?Ser?His?Leu?Pro?Glu?Leu

210 215 220

Ile?Trp?Arg?Ser?Val?Thr?Val?Lys?Gly?Ser?Val?Val?Gly?Gln?Asp?Leu

225 230 235 240

Lys?Glu?Ser?Ser?Leu?Arg?Glu?Ile?Leu?Asn?Tyr?Gly?His?Thr?Phe?Ala

245 250 255

His?Ala?Val?Glu?Leu?Arg?Glu?Asn?Phe?Arg?Trp?Arg?His?Gly?Asn?Ala

260 265 270

Val?Ala?Val?Gly?Met?Met?Phe?Ile?Ala?Asn?Leu?Ser?His?Lys?Leu?Gly

275 280 285

Leu?Ile?Asp?Ala?Pro?Leu?Leu?Glu?Arg?His?Arg?Ser?Ile?Leu?Ala?Ala

290 295 300

Ile?Gly?Leu?Pro?Thr?Ser?Tyr?Glu?Gly?Gly?Ala?Phe?Asp?Glu?Leu?Tyr

305 310 315 320

Asp?Gly?Met?Thr?Arg?Asp?Lys?Lys?Asn?Arg?Asp?Gly?Asn?Ile?Arg?Phe

325 330 335

Val?Ala?Leu?Thr?Ala?Val?Gly?Glu?Val?Thr?Arg?Ile?Glu?Gly?Pro?Ser

340 345 350

Lys?Gln?Asp?Leu?Gln?Ser?Ala?Tyr?Glu?Ala?Ile?Ser?His

355 360 365

<210>395

<211>1977

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1954)

<223>RXN02508

<400>395

tgcacactgc?tggtggtgag?gccgcagacc?tggcagccgc?aagcaaagcc?tccgaggccc?60

aactcgcggc?tcagtaaaac?caaaaggaat?ctttgaccac?atg?cgt?aca?tcc?att 115

Met?Arg?Thr?Ser?Ile

1 5

gcc?act?gtt?tgt?ttg?tcc?gga?act?ctt?gct?gaa?aag?ctg?cgc?gca?gct 163

Ala?Thr?Val?Cys?Leu?Ser?Gly?Thr?Leu?Ala?Glu?Lys?Leu?Arg?Ala?Ala

10 15 20

gca?gat?gct?gga?ttt?gat?ggt?gtg?gaa?atc?ttc?gag?cag?gac?ttg?gtg 211

Ala?Asp?Ala?Gly?Phe?Asp?Gly?Val?Glu?Ile?Phe?Glu?Gln?Asp?Leu?Val

25 30 35

gtt?tcc?ccg?cat?tcg?gca?gag?cag?att?cgt?cag?cgg?gct?cag?gat?ttg 259

Val?Ser?Pro?His?Ser?Ala?Glu?Gln?Ile?Arg?Gln?Arg?Ala?Gln?Asp?Leu

40 45 50

gga?tta?acc?ctg?gat?ctg?ttc?cag?ccg?ttt?cga?gat?ttc?gaa?ggt?gtg 307

Gly?Leu?Thr?Leu?Asp?Leu?Phe?Gln?Pro?Phe?Arg?Asp?Phe?Glu?Gly?Val

55 60 65

gaa?gaa?gag?cag?ttt?ctg?aag?aat?ctg?cac?cgc?ttg?gaa?gag?aag?ttc 355

Glu?Glu?Glu?Gln?Phe?Leu?Lys?Asn?Leu?His?Arg?Leu?Glu?Glu?Lys?Phe

70 75 80 85

aag?ctg?atg?aac?agg?ctt?ggc?att?gag?atg?atc?ttg?ttg?tgt?tcc?aat 403

Lys?Leu?Met?Asn?Arg?Leu?Gly?Ile?Glu?Met?Ile?Leu?Leu?Cys?Ser?Asn

90 95 100

gtg?ggc?acc?gcg?acc?atc?aat?gat?gat?gac?ctt?ttc?gtg?gag?cag?ttg 451

Val?Gly?Thr?Ala?Thr?Ile?Asn?Asp?Asp?Asp?Leu?Phe?Val?Glu?Gln?Leu

105 110 115

cat?cgt?gca?gca?gat?ttg?gct?gag?aag?tac?aac?gtc?aag?att?gct?tat 499

His?Arg?Ala?Ala?Asp?Leu?Ala?Glu?Lys?Tyr?Asn?Val?Lys?Ile?Ala?Tyr

120 125 130

gaa?gcg?ttg?gcg?tgg?ggc?aag?ttt?gtc?aat?gat?ttt?gag?cat?gcg?cat 547

Glu?Ala?Leu?Ala?Trp?Gly?Lys?Phe?Val?Asn?Asp?Phe?Glu?His?Ala?His

135 140 145

gca?ctt?gtg?gag?aag?gtg?aat?cac?aag?gcg?ctg?gga?acc?tgc?ttg?gat 595

Ala?Leu?Val?Glu?Lys?Val?Asn?His?Lys?Ala?Leu?Gly?Thr?Cys?Leu?Asp

150 155 160 165

acg?ttc?cat?att?ctt?tcc?cgt?ggt?tgg?gaa?acc?gac?gag?gtg?gag?aac 643

Thr?Phe?His?Ile?Leu?Ser?Arg?Gly?Trp?Glu?Thr?Asp?Glu?Val?Glu?Asn

170 175 180

atc?cct?gcg?gag?aag?atc?ttc?ttt?gtt?cag?tta?gcg?gat?gcg?ccg?aag 691

Ile?Pro?Ala?Glu?Lys?Ile?Phe?Phe?Val?Gln?Leu?Ala?Asp?Ala?Pro?Lys

185 190 195

ctg?agc?atg?gac?att?ttg?tcc?tgg?tcg?cgt?cac?cac?cgt?gtt?ttc?cct 739

Leu?Ser?Met?Asp?Ile?Leu?Ser?Trp?Ser?Arg?His?His?Arg?Val?Phe?Pro

200 205 210

ggt?gaa?ggc?gat?ttc?gat?ctg?gtg?aaa?ttc?atg?gtt?cat?ctg?gcc?aag 787

Gly?Glu?Gly?Asp?Phe?Asp?Leu?Val?Lys?Phe?Met?Val?His?Leu?Ala?Lys

215 220 225

acg?ggt?tat?gat?ggc?ccg?att?tct?ttg?gag?atc?ttc?aac?gat?tcc?ttc 835

Thr?Gly?Tyr?Asp?Gly?Pro?Ile?Ser?Leu?Glu?Ile?Phe?Asn?Asp?Ser?Phe

230 235 240 245

cgc?aag?gcc?gag?gtt?ggt?cgc?acc?gcg?att?gat?ggg?ttg?cgt?tct?ttg 883

Arg?Lys?Ala?Glu?Val?Gly?Arg?Thr?Ala?Ile?Asp?Gly?Leu?Arg?Ser?Leu

250 255 260

cgt?tgg?ttg?gaa?gat?cag?acc?tgg?cat?gcg?cta?aat?gct?gag?gat?cgt 931

Arg?Trp?Leu?Glu?Asp?Gln?Thr?Trp?His?Ala?Leu?Asn?Ala?Glu?Asp?Arg

265 270 275

cca?agc?gct?ctt?gaa?ctg?cgt?gca?ctt?cct?gag?gtc?gcg?gaa?cct?gag 979

Pro?Ser?Ala?Leu?Glu?Leu?Arg?Ala?Leu?Pro?Glu?Val?Ala?Glu?Pro?Glu

280 285 290

ggt?gtt?gat?ttc?att?gag?atc?gcc?act?gga?cgt?ttg?ggt?gag?acc?att 1027

Gly?Val?Asp?Phe?Ile?Glu?Ile?Ala?Thr?Gly?Arg?Leu?Gly?Glu?Thr?Ile

295 300 305

cgg?gtt?ctt?cat?caa?ttg?ggt?ttc?cgc?ttg?ggt?ggt?cat?cac?tgc?agt 1075

Arg?Val?Leu?His?Gln?Leu?Gly?Phe?Arg?Leu?Gly?Gly?His?His?Cys?Ser

310 315 320 325

aag?cag?gat?tac?cag?gta?tgg?acc?cag?ggc?gat?gtg?cgc?att?gtg?gtg 1123

Lys?Gln?Asp?Tyr?Gln?Val?Trp?Thr?Gln?Gly?Asp?Val?Arg?Ile?Val?Val

330 335 340

tgt?gat?cgt?ggg?gtc?acc?ggg?gct?cca?acc?acg?atc?tct?gcg?atg?ggc 1171

Cys?Asp?Arg?Gly?Val?Thr?Gly?Ala?Pro?Thr?Thr?Ile?Ser?Ala?Met?Gly

345 350 355

ttt?gac?acc?ccc?gat?cca?gaa?gct?gct?cat?gcc?cgt?gcg?gaa?ttg?ctg 1219

Phe?Asp?Thr?Pro?Asp?Pro?Glu?Ala?Ala?His?Ala?Arg?Ala?Glu?Leu?Leu

360 365 370

cgg?gct?cag?aca?att?gat?cgt?ccc?cac?atc?gag?ggc?gaa?gtt?gac?cta 1267

Arg?Ala?Gln?Thr?Ile?Asp?Arg?Pro?His?Ile?Glu?Gly?Glu?Val?Asp?Leu

375 380 385

aaa?ggt?gtg?tac?gca?ccg?gat?ggg?gtg?gag?ctg?ttt?ttc?gcg?ggg?ccg 1315

Lys?Gly?Val?Tyr?Ala?Pro?Asp?Gly?Val?Glu?Leu?Phe?Phe?Ala?Gly?Pro

390 395 400 405

agc?ccc?gat?gga?atg?ccc?gag?tgg?ctg?ccg?gaa?ttc?ggc?gtc?gaa?aag 1363

Ser?Pro?Asp?Gly?Met?Pro?Glu?Trp?Leu?Pro?Glu?Phe?Gly?Val?Glu?Lys

410 415 420

caa?gaa?gct?ggt?ctc?att?gaa?gcc?atc?gac?cac?gtc?aat?ttc?gcc?cag 1411

Gln?Glu?Ala?Gly?Leu?Ile?Glu?Ala?Ile?Asp?His?Val?Asn?Phe?Ala?Gln

425 430 435

ccg?tgg?caa?cat?ttt?gat?gag?gca?gtg?ctg?ttt?tac?acc?gcg?ctg?atg 1459

Pro?Trp?Gln?His?Phe?Asp?Glu?Ala?Val?Leu?Phe?Tyr?Thr?Ala?Leu?Met

440 445 450

gcg?ttg?gag?act?gtg?cgt?gag?gat?gag?ttc?ccg?agc?cca?att?ggt?ttg 1507

Ala?Leu?Glu?Thr?Val?Arg?Glu?Asp?Glu?Phe?Pro?Ser?Pro?Ile?Gly?Leu

455 460 465

gtg?cgc?aat?cag?gtg?atg?cgt?tcg?ccg?aat?gat?gcg?gtg?cgg?ttg?ctg 1555

Val?Arg?Asn?Gln?Val?Met?Arg?Ser?Pro?Asn?Asp?Ala?Val?Arg?Leu?Leu

470 475 480 485

ctc?agc?gtg?gcg?ccc?gag?gac?ggt?gag?cag?gga?gat?ttc?ctc?aac?gcg 1603

Leu?Ser?Val?Ala?Pro?Glu?Asp?Gly?Glu?Gln?Gly?Asp?Phe?Leu?Asn?Ala

490 495 500

gcc?tac?ccg?gag?cac?att?gcg?ttg?gcc?acg?gcg?gac?atc?gtg?gcg?gtg 1651

Ala?Tyr?Pro?Glu?His?Ile?Ala?Leu?Ala?Thr?Ala?Asp?Ile?Val?Ala?Val

505 510 515

gct?gaa?cgt?gcg?cgc?aaa?cga?ggc?ctg?gat?ttc?ttg?ccc?gtc?cca?gag 1699

Ala?Glu?Arg?Ala?Arg?Lys?Arg?Gly?Leu?Asp?Phe?Leu?Pro?Val?Pro?Glu

520 525 530

aat?tac?tac?gac?gat?gtg?cag?gcg?cgt?ttt?gat?ttg?ccg?cag?gaa?ttc 1747

Asn?Tyr?Tyr?Asp?Asp?Val?Gln?Ala?Arg?Phe?Asp?Leu?Pro?Gln?Glu?Phe

535 540 545

ttg?gac?aca?ctc?aag?gaa?aac?cac?ctg?ctt?tac?gac?cgc?gac?gag?aac 1795

Leu?Asp?Thr?Leu?Lys?Glu?Asn?His?Leu?Leu?Tyr?Asp?Arg?Asp?Glu?Asn

550 555 560 565

ggc?gaa?ttc?ctc?cac?ttt?tac?acc?cgc?acg?ttg?ggc?acg?ctg?ttc?ttc 1843

Gly?Glu?Phe?Leu?His?Phe?Tyr?Thr?Arg?Thr?Leu?Gly?Thr?Leu?Phe?Phe

570 575 580

gaa?gtg?gtg?gaa?cgc?cgc?ggc?ggt?ttt?gca?ggt?tgg?ggc?gaa?aca?aac 1891

Glu?Val?Val?Glu?Arg?Arg?Gly?Gly?Phe?Ala?Gly?Trp?Gly?Glu?Thr?Asn

585 590 595

gct?ccg?gtg?cgg?ttg?gcg?gcg?cag?tat?cgt?gag?gtg?cgg?gac?ctc?gag 1939

Ala?Pro?Val?Arg?Leu?Ala?Ala?Gln?Tyr?Arg?Glu?Val?Arg?Asp?Leu?Glu

600 605 610

cgg?gga?atc?cca?aac?tagcatcccg?aactagcccc?cca 1977

Arg?Gly?Ile?Pro?Asn

615

<210>396

<211>618

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>396

Met?Arg?Thr?Ser?Ile?Ala?Thr?Val?Cys?Leu?Ser?Gly?Thr?Leu?Ala?Glu

1 5 10 15

Lys?Leu?Arg?Ala?Ala?Ala?Asp?Ala?Gly?Phe?Asp?Gly?Val?Glu?Ile?Phe

20 25 30

Glu?Gln?Asp?Leu?Val?Val?Ser?Pro?His?Ser?Ala?Glu?Gln?Ile?Arg?Gln

35 40 45

Arg?Ala?Gln?Asp?Leu?Gly?Leu?Thr?Leu?Asp?Leu?Phe?Gln?Pro?Phe?Arg

50 55 60

Asp?Phe?Glu?Gly?Val?Glu?Glu?Glu?Gln?Phe?Leu?Lys?Asn?Leu?His?Arg

65 70 75 80

Leu?Glu?Glu?Lys?Phe?Lys?Leu?Met?Asn?Arg?Leu?Gly?Ile?Glu?Met?Ile

85 90 95

Leu?Leu?Cys?Ser?Asn?Val?Gly?Thr?Ala?Thr?Ile?Asn?Asp?Asp?Asp?Leu

100 105 110

Phe?Val?Glu?Gln?Leu?His?Arg?Ala?Ala?Asp?Leu?Ala?Glu?Lys?Tyr?Asn

115 120 125

Val?Lys?Ile?Ala?Tyr?Glu?Ala?Leu?Ala?Trp?Gly?Lys?Phe?Val?Asn?Asp

130 135 140

Phe?Glu?His?Ala?His?Ala?Leu?Val?Glu?Lys?Val?Asn?His?Lys?Ala?Leu

145 150 155 160

Gly?Thr?Cys?Leu?Asp?Thr?Phe?His?Ile?Leu?Ser?Arg?Gly?Trp?Glu?Thr

165 170 175

Asp?Glu?Val?Glu?Asn?Ile?Pro?Ala?Glu?Lys?Ile?Phe?Phe?Val?Gln?Leu

180 185 190

Ala?Asp?Ala?Pro?Lys?Leu?Ser?Met?Asp?Ile?Leu?Ser?Trp?Ser?Arg?His

195 200 205

His?Arg?Val?Phe?Pro?Gly?Glu?Gly?Asp?Phe?Asp?Leu?Val?Lys?Phe?Met

210 215 220

Val?His?Leu?Ala?Lys?Thr?Gly?Tyr?Asp?Gly?Pro?Ile?Ser?Leu?Glu?Ile

225 230 235 240

Phe?Asn?Asp?Ser?Phe?Arg?Lys?Ala?Glu?Val?Gly?Arg?Thr?Ala?Ile?Asp

245 250 255

Gly?Leu?Arg?Ser?Leu?Arg?Trp?Leu?Glu?Asp?Gln?Thr?Trp?His?Ala?Leu

260 265 270

Asn?Ala?Glu?Asp?Arg?Pro?Ser?Ala?Leu?Glu?Leu?Arg?Ala?Leu?Pro?Glu

275 280 285

Val?Ala?Glu?Pro?Glu?Gly?Val?Asp?Phe?Ile?Glu?Ile?Ala?Thr?Gly?Arg

290 295 300

Leu?Gly?Glu?Thr?Ile?Arg?Val?Leu?His?Gln?Leu?Gly?Phe?Arg?Leu?Gly

305 310 315 320

Gly?His?His?Cys?Ser?Lys?Gln?Asp?Tyr?Gln?Val?Trp?Thr?Gln?Gly?Asp

325 330 335

Val?Arg?Ile?Val?Val?Cys?Asp?Arg?Gly?Val?Thr?Gly?Ala?Pro?Thr?Thr

340 345 350

Ile?Ser?Ala?Met?Gly?Phe?Asp?Thr?Pro?Asp?Pro?Glu?Ala?Ala?His?Ala

355 360 365

Arg?Ala?Glu?Leu?Leu?Arg?Ala?Gln?Thr?Ile?Asp?Arg?Pro?His?Ile?Glu

370 375 380

Gly?Glu?Val?Asp?Leu?Lys?Gly?Val?Tyr?Ala?Pro?Asp?Gly?Val?Glu?Leu

385 390 395 400

Phe?Phe?Ala?Gly?Pro?Ser?Pro?Asp?Gly?Met?Pro?Glu?Trp?Leu?Pro?Glu

405 410 415

Phe?Gly?Val?Glu?Lys?Gln?Glu?Ala?Gly?Leu?Ile?Glu?Ala?Ile?Asp?His

420 425 430

Val?Asn?Phe?Ala?Gln?Pro?Trp?Gln?His?Phe?Asp?Glu?Ala?Val?Leu?Phe

435 440 445

Tyr?Thr?Ala?Leu?Met?Ala?Leu?Glu?Thr?Val?Arg?Glu?Asp?Glu?Phe?Pro

450 455 460

Ser?Pro?Ile?Gly?Leu?Val?Arg?Asn?Gln?Val?Met?Arg?Ser?Pro?Asn?Asp

465 470 475 480

Ala?Val?Arg?Leu?Leu?Leu?Ser?Val?Ala?Pro?Glu?Asp?Gly?Glu?Gln?Gly

485 490 495

Asp?Phe?Leu?Asn?Ala?Ala?Tyr?Pro?Glu?His?Ile?Ala?Leu?Ala?Thr?Ala

500 505 510

Asp?Ile?Val?Ala?Val?Ala?Glu?Arg?Ala?Arg?Lys?Arg?Gly?Leu?Asp?Phe

515 520 525

Leu?Pro?Val?Pro?Glu?Asn?Tyr?Tyr?Asp?Asp?Val?Gln?Ala?Arg?Phe?Asp

530 535 540

Leu?Pro?Gln?Glu?Phe?Leu?Asp?Thr?Leu?Lys?Glu?Asn?His?Leu?Leu?Tyr

545 550 555 560

Asp?Arg?Asp?Glu?Asn?Gly?Glu?Phe?Leu?His?Phe?Tyr?Thr?Arg?Thr?Leu

565 570 575

Gly?Thr?Leu?Phe?Phe?Glu?Val?Val?Glu?Arg?Arg?Gly?Gly?Phe?Ala?Gly

580 585 590

Trp?Gly?Glu?Thr?Asn?Ala?Pro?Val?Arg?Leu?Ala?Ala?Gln?Tyr?Arg?Glu

595 600 605

Val?Arg?Asp?Leu?Glu?Arg?Gly?Ile?Pro?Asn

610 615

<210>397

<211>470

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(447)

<223>RXN02839

<400>397

tgt?gtg?gtg?aat?gat?tat?gct?gac?cgc?aag?ttt?gat?ggt?cat?gtt?aag 48

Cys?Val?Val?Asn?Asp?Tyr?Ala?Asp?Arg?Lys?Phe?Asp?Gly?His?Val?Lys

1 5 10 15

cgc?acg?gcg?aac?cga?cca?ctt?ccc?agc?ggc?gcg?gta?aca?gag?aaa?gag 96

Arg?Thr?Ala?Asn?Arg?Pro?Leu?Pro?Ser?Gly?Ala?Val?Thr?Glu?Lys?Glu

20 25 30

gcg?cgc?gcg?ctg?ttt?gtc?gtg?ctg?gta?ctg?att?tcg?ttt?tta?ctg?gtg 144

Ala?Arg?Ala?Leu?Phe?Val?Val?Leu?Val?Leu?Ile?Ser?Phe?Leu?Leu?Val

35 40 45

ctg?acg?ctg?aat?acg?atg?acc?att?ctg?ttg?tcg?att?gcc?gcg?cta?gcg 192

Leu?Thr?Leu?Asn?Thr?Met?Thr?Ile?Leu?Leu?Ser?Ile?Ala?Ala?Leu?Ala

50 55 60

ctg?gcg?tgg?gtg?tac?ccg?ttt?atg?aag?cgg?tat?acc?cat?cta?ccg?caa 240

Leu?Ala?Trp?Val?Tyr?Pro?Phe?Met?Lys?Arg?Tyr?Thr?His?Leu?Pro?Gln

65 70 75 80

gtg?gtg?ctg?ggc?gcg?gcg?ttt?ggc?tgg?tcg?att?cca?atg?gct?ttt?gcc 288

Val?Val?Leu?Gly?Ala?Ala?Phe?Gly?Trp?Ser?Ile?Pro?Met?Ala?Phe?Ala

85 90 95

gct?gtg?agt?gag?tcg?gtg?cca?ttg?agt?tgc?tgg?tta?atg?ttc?ctc?gcc 336

Ala?Val?Ser?Glu?Ser?Val?Pro?Leu?Ser?Cys?Trp?Leu?Met?Phe?Leu?Ala

100 105 110

aat?att?ctc?tgg?gcg?gtg?gct?tac?gac?acg?cag?tat?gcg?atg?gtt?gac 384

Asn?Ile?Leu?Trp?Ala?Val?Ala?Tyr?Asp?Thr?Gln?Tyr?Ala?Met?Val?Asp

115 120 125

cgc?gat?gat?gat?gtg?aag?att?ggc?att?aaa?tcc?acg?gca?atc?ctg?ttg 432

Arg?Asp?Asp?Asp?Val?Lys?Ile?Gly?Ile?Lys?Ser?Thr?Ala?Ile?Leu?Leu

130 135 140

gcc?aat?acg?ata?aat?tgatattggg?attttgcaga?ttg 470

Ala?Asn?Thr?Ile?Asn

145

<210>398

<211>149

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>398

Cys?Val?Val?Asn?Asp?Tyr?Ala?Asp?Arg?Lys?Phe?Asp?Gly?His?Val?Lys

1 5 10 15

Arg?Thr?Ala?Asn?Arg?Pro?Leu?Pro?Ser?Gly?Ala?Val?Thr?Glu?Lys?Glu

20 25 30

Ala?Arg?Ala?Leu?Phe?Val?Val?Leu?Val?Leu?Ile?Ser?Phe?Leu?Leu?Val

35 40 45

Leu?Thr?Leu?Asn?Thr?Met?Thr?Ile?Leu?Leu?Ser?Ile?Ala?Ala?Leu?Ala

50 55 60

Leu?Ala?Trp?Val?Tyr?Pro?Phe?Met?Lys?Arg?Tyr?Thr?His?Leu?Pro?Gln

65 70 75 80

Val?Val?Leu?Gly?Ala?Ala?Phe?Gly?Trp?Ser?Ile?Pro?Met?Ala?Phe?Ala

85 90 95

Ala?Val?Ser?Glu?Ser?Val?Pro?Leu?Ser?Cys?Trp?Leu?Met?Phe?Leu?Ala

100 105 110

Asn?Ile?Leu?Trp?Ala?Val?Ala?Tyr?Asp?Thr?Gln?Tyr?Ala?Met?Val?Asp

115 120 125

Arg?Asp?Asp?Asp?Val?Lys?Ile?Gly?Ile?Lys?Ser?Thr?Ala?Ile?Leu?Leu

130 135 140

Ala?Asn?Thr?Ile?Asn

145

<210>399

<211>978

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(955)

<223>RXN00639

<400>399

agtgttgtta?tcgagttcag?ccgatcacaa?agatttttcc?gctaggcagt?gatccgactc?60

gcacccccta?cttcaccccc?aaagtctcta?ggagtatgac?atg?act?tca?gct?gaa 115

Met?Thr?Ser?Ala?Glu

1 5

cag?atc?gtt?gat?cca?aca?gcc?cac?gat?tcg?ggc?aac?aag?gca?act?gac 163

Gln?Ile?Val?Asp?Pro?Thr?Ala?His?Asp?Ser?Gly?Asn?Lys?Ala?Thr?Asp

10 15 20

aag?ttc?aag?gca?aac?cgc?gtt?tcc?tcc?gat?acc?tcc?aag?gaa?cgc?gca 211

Lys?Phe?Lys?Ala?Asn?Arg?Val?Ser?Ser?Asp?Thr?Ser?Lys?Glu?Arg?Ala

25 30 35

aac?gcg?atc?tac?gta?gat?ctg?ctc?gcg?gcg?atc?gcc?cag?gtt?gct?cac 259

Asn?Ala?Ile?Tyr?Val?Asp?Leu?Leu?Ala?Ala?Ile?Ala?Gln?Val?Ala?His

40 45 50

aag?cac?gaa?gtc?acc?tac?gaa?gag?tac?gca?gtg?ctc?aag?cag?tgg?atg 307

Lys?His?Glu?Val?Thr?Tyr?Glu?Glu?Tyr?Ala?Val?Leu?Lys?Gln?Trp?Met

55 60 65

atc?gac?gtt?gga?gaa?tac?ggc?gag?tgg?cca?ctg?tgg?ttg?gac?gtt?ttc 355

Ile?Asp?Val?Gly?Glu?Tyr?Gly?Glu?Trp?Pro?Leu?Trp?Leu?Asp?Val?Phe

70 75 80 85

gtt?gag?cat?gag?atc?gaa?gag?atc?aac?tac?aac?cgc?cac?gac?tac?acc 403

Val?Glu?His?Glu?Ile?Glu?Glu?Ile?Asn?Tyr?Asn?Arg?His?Asp?Tyr?Thr

90 95 100

gga?acc?aag?ggt?tcc?atc?gaa?ggc?cct?tat?tac?gta?gag?aac?tct?ccg 451

Gly?Thr?Lys?Gly?Ser?Ile?Glu?Gly?Pro?Tyr?Tyr?Val?Glu?Asn?Ser?Pro

105 110 115

aag?ctc?cct?tgg?gat?gct?gaa?atg?cca?atg?cgt?gac?aag?gac?cgc?gca 499

Lys?Leu?Pro?Trp?Asp?Ala?Glu?Met?Pro?Met?Arg?Asp?Lys?Asp?Arg?Ala

120 125 130

tgc?acc?cca?ctg?atc?ttc?gag?ggg?cag?gtt?act?gac?ctc?gac?ggc?aac 547

Cys?Thr?Pro?Leu?Ile?Phe?Glu?Gly?Gln?Val?Thr?Asp?Leu?Asp?Gly?Asn

135 140 145

ggt?ctt?gat?gga?gca?gaa?gtt?gag?ctc?tgg?cac?gca?gat?gag?gac?gga 595

Gly?Leu?Asp?Gly?Ala?Glu?Val?Glu?Leu?Trp?His?Ala?Asp?Glu?Asp?Gly

150 155 160 165

tac?tac?tcc?cag?ttc?gcg?cct?gga?atc?cca?gag?tgg?aac?ctg?cgt?ggc 643

Tyr?Tyr?Ser?Gln?Phe?Ala?Pro?Gly?Ile?Pro?Glu?Trp?Asn?Leu?Arg?Gly

170 175 180

acc?atc?gtt?acc?gat?gag?gaa?ggc?cgc?tac?aag?atc?aag?acc?ctg?cag 691

Thr?Ile?Val?Thr?Asp?Glu?Glu?Gly?Arg?Tyr?Lys?Ile?Lys?Thr?Leu?Gln

185 190 195

cct?gcg?cct?tac?cag?atc?cct?cat?gat?ggc?cca?acc?ggt?tgg?ttc?att 739

Pro?Ala?Pro?Tyr?Gln?Ile?Pro?His?Asp?Gly?Pro?Thr?Gly?Trp?Phe?Ile

200 205 210

gag?tct?tac?ggt?ggg?cac?cca?tgg?cgc?cca?gcc?cac?ctc?cac?ttg?cgc 787

Glu?Ser?Tyr?Gly?Gly?His?Pro?Trp?Arg?Pro?Ala?His?Leu?His?Leu?Arg

215 220 225

gtt?tcc?cac?ccg?ggc?tac?cgc?acc?atc?acc?acc?cag?ctt?tac?ttc?gag 835

Val?Ser?His?Pro?Gly?Tyr?Arg?Thr?Ile?Thr?Thr?Gln?Leu?Tyr?Phe?Glu

230 235 240 245

ggt?ggc?gag?tgg?gtc?gaa?aac?gac?gtt?gca?acc?gct?gtg?aag?cca?gaa 883

Gly?Gly?Glu?Trp?Val?Glu?Asn?Asp?Val?Ala?Thr?Ala?Val?Lys?Pro?Glu

250 255 260

ctg?gtc?ctg?cac?cct?gag?act?ggc?gag?gat?ggt?aac?cac?gtt?cac?tac 931

Leu?Val?Leu?His?Pro?Glu?Thr?Gly?Glu?Asp?Gly?Asn?His?Val?His?Tyr

265 270 275

cea?ttc?gtc?ctg?gat?aag?gaa?gac?tagtttttct?acctagctag?cat 978

Pro?Phe?Val?Leu?Asp?Lys?Glu?Asp

280 285

<210>400

<211>285

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>400

Met?Thr?Ser?Ala?Glu?Gln?Ile?Val?Asp?Pro?Thr?Ala?His?Asp?Ser?Gly

1 5 10 15

Asn?Lys?Ala?Thr?Asp?Lys?Phe?Lys?Ala?Asn?Arg?Val?Ser?Ser?Asp?Thr

20 25 30

Ser?Lys?Glu?Arg?Ala?Asn?Ala?Ile?Tyr?Val?Asp?Leu?Leu?Ala?Ala?Ile

35 40 45

Ala?Gln?Val?Ala?His?Lys?His?Glu?Val?Thr?Tyr?Glu?Glu?Tyr?Ala?Val

50 55 60

Leu?Lys?Gln?Trp?Met?Ile?Asp?Val?Gly?Glu?Tyr?Gly?Glu?Trp?Pro?Leu

65 70 75 80

Trp?Leu?Asp?Val?Phe?Val?Glu?His?Glu?Ile?Glu?Glu?Ile?Asn?Tyr?Asn

85 90 95

Arg?His?Asp?Tyr?Thr?Gly?Thr?Lys?Gly?Ser?Ile?Glu?Gly?Pro?Tyr?Tyr

100 105 110

Val?Glu?Asn?Ser?Pro?Lys?Leu?Pro?Trp?Asp?Ala?Glu?Met?Pro?Met?Arg

115 120 125

Asp?Lys?Asp?Arg?Ala?Cys?Thr?Pro?Leu?Ile?Phe?Glu?Gly?Gln?Val?Thr

130 135 140

Asp?Leu?Asp?Gly?Asn?Gly?Leu?Asp?Gly?Ala?Glu?Val?Glu?Leu?Trp?His

145 150 155 160

Ala?Asp?Glu?Asp?Gly?Tyr?Tyr?Ser?Gln?Phe?Ala?Pro?Gly?Ile?Pro?Glu

165 170 175

Trp?Asn?Leu?Arg?Gly?Thr?Ile?Val?Thr?Asp?Glu?Glu?Gly?Arg?Tyr?Lys

180 185 190

Ile?Lys?Thr?Leu?Gln?Pro?Ala?Pro?Tyr?Gln?Ile?Pro?His?Asp?Gly?Pro

195 200 205

Thr?Gly?Trp?Phe?Ile?Glu?Ser?Tyr?Gly?Gly?His?Pro?Trp?Arg?Pro?Ala

210 215 220

His?Leu?His?Leu?Arg?Val?Ser?His?Pro?Gly?Tyr?Arg?Thr?Ile?Thr?Thr

225 230 235 240

Gln?Leu?Tyr?Phe?Glu?Gly?Gly?Glu?Trp?Val?Glu?Asn?Asp?Val?Ala?Thr

245 250 255

Ala?Val?Lys?Pro?Glu?Leu?Val?Leu?His?Pro?Glu?Thr?Gly?Glu?Asp?Gly

260 265 270

Asn?His?Val?His?Tyr?Pro?Phe?Val?Leu?Asp?Lys?Glu?Asp

275 280 285

<210>401

<211>780

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(757)

<223>RXN02530

<400>401

gaggctgagc?tttccgtcaa?acaacatctt?cccaatgtgg?atgaaatgac?tgtgaccatc?60

accccttcca?aaccttgagt?cccgtgatac?aattgttgat?atg?tca?aca?aat?tat 115

Met?Ser?Thr?Asn?Tyr

1 5

gaa?gca?atc?atc?att?gga?gca?ggt?cag?gct?gga?ctc?gcg?gcg?gcg?cat 163

Glu?Ala?Ile?Ile?Ile?Gly?Ala?Gly?Gln?Ala?Gly?Leu?Ala?Ala?Ala?His

10 15 20

gaa?ctt?tcc?cgc?cgc?ggt?ttc?act?ccc?gga?aaa?gat?ttt?ctc?gtc?ctc 211

Glu?Leu?Ser?Arg?Arg?Gly?Phe?Thr?Pro?Gly?Lys?Asp?Phe?Leu?Val?Leu

25 30 35

gat?tcc?aac?gac?ggg?ccc?ggt?ggc?gcc?tgg?cgg?cat?agg?tgg?gat?tca 259

Asp?Ser?Asn?Asp?Gly?Pro?Gly?Gly?Ala?Trp?Arg?His?Arg?Trp?Asp?Ser

40 45 50

ctc?aca?tta?ggt?aaa?gcc?cac?gga?atc?gcc?gat?ctc?cca?ggg?ctt?ccc 307

Leu?Thr?Leu?Gly?Lys?Ala?His?Gly?Ile?Ala?Asp?Leu?Pro?Gly?Leu?Pro

55 60 65

atg?aat?cgc?ccc?gat?ccg?aaa?act?ccg?gct?tcc?aca?ttg?gtt?gct?ggt 355

Met?Asn?Arg?Pro?Asp?Pro?Lys?Thr?Pro?Ala?Ser?Thr?Leu?Val?Ala?Gly

70 75 80 85

tat?tac?ggc?gct?tac?gag?aac?gag?ttc?tcc?ttc?gca?gtt?gtg?cgc?cca 403

Tyr?Tyr?Gly?Ala?Tyr?Glu?Asn?Glu?Phe?Ser?Phe?Ala?Val?Val?Arg?Pro

90 95 100

gtc?aaa?gtc?tca?cga?gtt?gag?ccc?act?tcc?gag?gat?cct?tcg?agc?cca 451

Val?Lys?Val?Ser?Arg?Val?Glu?Pro?Thr?Ser?Glu?Asp?Pro?Ser?Ser?Pro

105 110 115

ttg?cgc?gtg?agc?agc?gac?gat?ggt?cga?gag?tgg?att?acc?cgc?atg?gtt 499

Leu?Arg?Val?Ser?Ser?Asp?Asp?Gly?Arg?Glu?Trp?Ile?Thr?Arg?Met?Val

120 125 130

ctt?aat?gca?aca?ggt?acg?tgg?aca?aac?cct?tat?gtt?ccg?tac?att?cct 547

Leu?Asn?Ala?Thr?Gly?Thr?Trp?Thr?Asn?Pro?Tyr?Val?Pro?Tyr?Ile?Pro

135 140 145

ggc?atc?gat?aaa?ttc?cag?ggc?aag?cag?ctc?cac?acc?gtt?aat?tac?cgc 595

Gly?Ile?Asp?Lys?Phe?Gln?Gly?Lys?Gln?Leu?His?Thr?Val?Asn?Tyr?Arg

150 155 160 165

aag?gcc?gag?gat?ttc?aaa?ggt?aag?aaa?gtc?ctg?gtc?gtc?ggc?ggt?ggt 643

Lys?Ala?Glu?Asp?Phe?Lys?Gly?Lys?Lys?Val?Leu?Val?Val?Gly?Gly?Gly

170 175 180

ttg?agt?gct?gtg?caa?ttt?ctg?ctg?gag?ttg?gaa?ggc?ttg?gcg?gaa?acc 691

Leu?Ser?Ala?Val?Gln?Phe?Leu?Leu?Glu?Leu?Glu?Gly?Leu?Ala?Glu?Thr

185 190 195

acc?tgg?gcg?acg?cgt?cgt?ccg?cga?act?tac?gca?gcg?cga?gtt?cga?cgc 739

Thr?Trp?Ala?Thr?Arg?Arg?Pro?Arg?Thr?Tyr?Ala?Ala?Arg?Val?Arg?Arg

200 205 210

cgg?ctg?ggg?cat?tgc?ggt?tgagcgcgcc?gtccgcgaac?gca 780

Arg?Leu?Gly?His?Cys?Gly

215

<210>402

<211>219

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>402

Met?Ser?Thr?Asn?Tyr?Glu?Ala?Ile?Ile?Ile?Gly?Ala?Gly?Gln?Ala?Gly

1 5 10 15

Leu?Ala?Ala?Ala?His?Glu?Leu?Ser?Arg?Arg?Gly?Phe?Thr?Pro?Gly?Lys

20 25 30

Asp?Phe?Leu?Val?Leu?Asp?Ser?Asn?Asp?Gly?Pro?Gly?Gly?Ala?Trp?Arg

35 40 45

His?Arg?Trp?Asp?Ser?Leu?Thr?Leu?Gly?Lys?Ala?His?Gly?Ile?Ala?Asp

50 55 60

Leu?Pro?Gly?Leu?Pro?Met?Asn?Arg?Pro?Asp?Pro?Lys?Thr?Pro?Ala?Ser

65 70 75 80

Thr?Leu?Val?Ala?Gly?Tyr?Tyr?Gly?Ala?Tyr?Glu?Asn?Glu?Phe?Ser?Phe

85 90 95

Ala?Val?Val?Arg?Pro?Val?Lys?Val?Ser?Arg?Val?Glu?Pro?Thr?Ser?Glu

100 105 110

Asp?Pro?Ser?Ser?Pro?Leu?Arg?Val?Ser?Ser?Asp?Asp?Gly?Arg?Glu?Trp

115 120 125

Ile?Thr?Arg?Met?Val?Leu?Asn?Ala?Thr?Gly?Thr?Trp?Thr?Asn?Pro?Tyr

130 135 140

Val?Pro?Tyr?Ile?Pro?Gly?Ile?Asp?Lys?Phe?Gln?Gly?Lys?Gln?Leu?His

145 150 155 160

Thr?Val?Asn?Tyr?Arg?Lys?Ala?Glu?Asp?Phe?Lys?Gly?Lys?Lys?Val?Leu

165 170 175

Val?Val?Gly?Gly?Gly?Leu?Ser?Ala?Val?Gln?Phe?Leu?Leu?Glu?Leu?Glu

180 185 190

Gly?Leu?Ala?Glu?Thr?Thr?Trp?Ala?Thr?Arg?Arg?Pro?Arg?Thr?Tyr?Ala

195 200 205

Ala?Arg?Val?Arg?Arg?Arg?Leu?Gly?His?Cys?Gly

210 2l5

<210>403

<211>990

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(967)

<223>RXN00434

<400>403

ccacgcgcca?aaccatgcaa?gccatcgtcc?aaactgagga?gaaggtcact?gcttctctgg?60

aattacagga?agtccccgtc?ccgaccctga?agccaggtag?gtg?ctg?gtg?aag?gtg 115

Val?Leu?Val?Lys?Val

1 5

aag?cct?gcg?ggc?gtt?aac?cgt?gcg?gat?ctt?ttg?cag?acg?cag?gga?aat 163

Lys?Pro?Ala?Gly?Val?Asn?Arg?Ala?Asp?Leu?Leu?Gln?Thr?Gln?Gly?Asn

10 15 20

tat?cct?gtg?ccg?gcg?ggg?gct?tcg?gag?att?ctc?ggg?ctg?gaa?tgt?gcg 211

Tyr?Pro?Val?Pro?Ala?Gly?Ala?Ser?Glu?Ile?Leu?Gly?Leu?Glu?Cys?Ala

25 30 35

ggt?gtg?atc?gtg?aat?gcc?ggc?gac?act?ggg?caa?aca?gtg?ggt?cag?gaa 259

Gly?Val?Ile?Val?Asn?Ala?Gly?Asp?Thr?Gly?Gln?Thr?Val?Gly?Gln?Glu

40 45 50

gtc?gct?tgc?ctt?ctc?act?ggc?ggt?gga?tat?gcg?caa?tat?gtg?gcg?gtt 307

Val?Ala?Cys?Leu?Leu?Thr?Gly?Gly?Gly?Tyr?Ala?Gln?Tyr?Val?Ala?Val

55 60 65

ccg?gaa?ggt?cag?ttg?atg?cca?att?cca?gag?ggt?tac?agc?ttt?gtg?gaa 355

Pro?Glu?Gly?Gln?Leu?Met?Pro?Ile?Pro?Glu?Gly?Tyr?Ser?Phe?Val?Glu

70 75 80 85

gcg?gcc?tcg?atc?gtg?gag?gtt?gcg?tgc?acg?gtg?tgg?tcg?aat?atc?ggc 403

Ala?Ala?Ser?Ile?Val?Glu?Val?Ala?Cys?Thr?Val?Trp?Ser?Asn?Ile?Gly

90 95 100

atg?ctg?gcg?ggc?ttg?cag?aag?gag?gat?act?ttc?ctt?att?cat?ggt?ggc 451

Met?Leu?Ala?Gly?Leu?Gln?Lys?Glu?Asp?Thr?Phe?Leu?Ile?His?Gly?Gly

105 110 115

gcg?ggc?ggt?atc?gga?acg?ttt?gcc?att?cag?atg?ggc?aag?gct?ctg?ggt 499

Ala?Gly?Gly?Ile?Gly?Thr?Phe?Ala?Ile?Gln?Met?Gly?Lys?Ala?Leu?Gly

120 125 130

gtg?acg?gtt?gcg?gtg?act?gcc?ggt?tca?act?gaa?aag?tta?aaa?acc?tgt 547

Val?Thr?Val?Ala?Val?Thr?Ala?Gly?Ser?Thr?Glu?Lys?Leu?Lys?Thr?Cys

135 140 145

aag?aac?tta?ggg?gcc?gat?atc?ctc?atc?aat?tac?aag?gag?gaa?gat?ttc 595

Lys?Asn?Leu?Gly?Ala?Asp?Ile?Leu?Ile?Asn?Tyr?Lys?Glu?Glu?Asp?Phe

150 155 160 165

gcc?gag?gtt?ttg?aag?aac?aag?gcg?gat?gtc?att?ctc?gat?att?att?ggt 643

Ala?Glu?Val?Leu?Lys?Asn?Lys?Ala?Asp?Val?Ile?Leu?Asp?Ile?Ile?Gly

170 175 180

gcg?aag?tat?ttg?tca?cag?aat?gtg?aag?gcg?atg?gcc?aag?gac?gcg?cac 691

Ala?Lys?Tyr?Leu?Ser?Gln?Asn?Val?Lys?Ala?Met?Ala?Lys?Asp?Ala?His

185 190 195

atg?gta?gtc?atc?ggg?atg?cag?ggt?ggc?gtg?aaa?ggg?gag?ctg?aat?ttg 739

Met?Val?Val?Ile?Gly?Met?Gln?Gly?Gly?Val?Lys?Gly?Glu?Leu?Asn?Leu

200 205 210

ggt?cat?ctt?ttg?gcc?aag?cga?ggc?acg?att?tct?gcc?act?gcg?ctg?cgt 787

Gly?His?Leu?Leu?Ala?Lys?Arg?Gly?Thr?Ile?Ser?Ala?Thr?Ala?Leu?Arg

215 220 225

ggt?cgc?gat?gag?gcg?gat?aag?gct?cgg?att?gtc?agc?agc?act?gtc?gaa 835

Gly?Arg?Asp?Glu?Ala?Asp?Lys?Ala?Arg?Ile?Val?Ser?Ser?Thr?Val?Glu

230 235 240 245

aat?att?tgg?ccg?ctg?ctg?caa?tcg?aag?gaa?att?acc?cct?cac?atc?gac 883

Asn?Ile?Trp?Pro?Leu?Leu?Gln?Ser?Lys?Glu?Ile?Thr?Pro?His?Ile?Asp

250 255 260

cac?acc?ttg?ccg?cta?gcc?gaa?gca?gcc?gcc?gcc?ttg?cag?aaa?att?caa 931

His?Thr?Leu?Pro?Leu?Ala?Glu?Ala?Ala?Ala?Ala?Leu?Gln?Lys?Ile?Gln

265 270 275

gac?ggc?acc?atc?acc?ggc?aag?ctc?gtg?ctt?gcg?gtt?taggcaagcg 977

Asp?Gly?Thr?Ile?Thr?Gly?Lys?Leu?Val?Leu?Ala?Val

280 285

atgccagcac?cct 990

<210>404

<211>289

<212>PRT

＜2l3〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>404

Val?Leu?Val?Lys?Val?Lys?Pro?Ala?Gly?Val?Asn?Arg?Ala?Asp?Leu?Leu

1 5 10 15

Gln?Thr?Gln?Gly?Asn?Tyr?Pro?Val?Pro?Ala?Gly?Ala?Ser?Glu?Ile?Leu

20 25 30

Gly?Leu?Glu?Cys?Ala?Gly?Val?Ile?Val?Asn?Ala?Gly?Asp?Thr?Gly?Gln

35 40 45

Thr?Val?Gly?Gln?Glu?Val?Ala?Cys?Leu?Leu?Thr?Gly?Gly?Gly?Tyr?Ala

50 55 60

Gln?Tyr?Val?Ala?Val?Pro?Glu?Gly?Gln?Leu?Met?Pro?Ile?Pro?Glu?Gly

65 70 75 80

Tyr?Ser?Phe?Val?Glu?Ala?Ala?Ser?Ile?Val?Glu?Val?Ala?Cys?Thr?Val

85 90 95

Trp?Ser?Asn?Ile?Gly?Met?Leu?Ala?Gly?Leu?Gln?Lys?Glu?Asp?Thr?Phe

100 105 110

Leu?Ile?His?Gly?Gly?Ala?Gly?Gly?Ile?Gly?Thr?Phe?Ala?Ile?Gln?Met

115 120 125

Gly?Lys?Ala?Leu?Gly?Val?Thr?Val?Ala?Val?Thr?Ala?Gly?Ser?Thr?Glu

130 135 140

Lys?Leu?Lys?Thr?Cys?Lys?Asn?Leu?Gly?Ala?Asp?Ile?Leu?Ile?Asn?Tyr

145 150 155 160

Lys?Glu?Glu?Asp?Phe?Ala?Glu?Val?Leu?Lys?Asn?Lys?Ala?Asp?Val?Ile

165 170 175

Leu?Asp?Ile?Ile?Gly?Ala?Lys?Tyr?Leu?Ser?Gln?Asn?Val?Lys?Ala?Met

180 185 190

Ala?Lys?Asp?Ala?His?Met?Val?Val?Ile?Gly?Met?Gln?Gly?Gly?Val?Lys

195 200 205

Gly?Glu?Leu?Asn?Leu?Gly?His?Leu?Leu?Ala?Lys?Arg?Gly?Thr?Ile?Ser

210 215 220

Ala?Thr?Ala?Leu?Arg?Gly?Arg?Asp?Glu?Ala?Asp?Lys?Ala?Arg?Ile?Val

225 230 235 240

Ser?Ser?Thr?Val?Glu?Asn?Ile?Trp?Pro?Leu?Leu?Gln?Ser?Lys?Glu?Ile

245 250 255

Thr?Pro?His?Ile?Asp?His?Thr?Leu?Pro?Leu?Ala?Glu?Ala?Ala?Ala?Ala

260 265 270

Leu?Gln?Lys?Ile?Gln?Asp?Gly?Thr?Ile?Thr?Gly?Lys?Leu?Val?Leu?Ala

275 280 285

Val

<210>405

<211>1098

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1075)

<223>RXN01619

<400>405

cctgcaagtt?tactgctcgg?ccgtcacggg?ggaatggaaa?aagtacgctt?ggtgttcata?60

tagcgaaccc?attttctatt?gcgatgagag?gaacaccacc?atg?cgc?gca?atc?act 115

Met?Arg?Ala?Ile?Thr

1 5

cac?aac?act?ttc?ggc?gac?ccc?gcc?gac?gtc?cta?cag?att?acc?gag?aag 163

His?Asn?Thr?Phe?Gly?Asp?Pro?Ala?Asp?Val?Leu?Gln?Ile?Thr?Glu?Lys

10 15 20

gaa?att?ccc?act?ccc?ggc?cca?ggt?cag?gtt?cgt?att?caa?gtg?acg?ctg 211

Glu?Ile?Pro?Thr?Pro?Gly?Pro?Gly?Gln?Val?Arg?Ile?Gln?Val?Thr?Leu

25 30 35

gca?acc?atc?cac?aac?cat?gat?ttg?tgg?acc?gtg?aag?ggc?tct?tac?ggc 259

Ala?Thr?Ile?His?Asn?His?Asp?Leu?Trp?Thr?Val?Lys?Gly?Ser?Tyr?Gly

40 45 50

ttc?gtc?cca?gat?ctg?ccg?gcc?gcc?gca?ggc?acc?gag?gca?gtc?ggc?atc 307

Phe?Val?Pro?Asp?Leu?Pro?Ala?Ala?Ala?Gly?Thr?Glu?Ala?Val?Gly?Ile

55 60 65

gtc?gac?gcc?ctg?ggc?gag?ggc?gtc?gaa?ggt?ttg?cag?gtc?ggt?cag?cgt 355

Val?Asp?Ala?Leu?Gly?Glu?Gly?Val?Glu?Gly?Leu?Gln?Val?Gly?Gln?Arg

70 75 80 85

gtt?gcg?tcc?ggc?acc?agc?ttt?ggc?atc?tgg?gcg?gag?tac?gcg?ctt?gtc 403

Val?Ala?Ser?Gly?Thr?Ser?Phe?Gly?Ile?Trp?Ala?Glu?Tyr?Ala?Leu?Val

90 95 100

gac?gcc?tcc?ggc?ctc?att?ccc?gta?cca?gaa?cag?ctc?tcc?gac?gaa?agc 451

Asp?Ala?Ser?Gly?Leu?Ile?Pro?Val?Pro?Glu?Gln?Leu?Ser?Asp?Glu?Ser

105 110 115

gca?gct?cag?ctc?gtc?gca?atg?cct?ttc?agc?gcc?atc?agc?ctt?ctt?gat 499

Ala?Ala?Gln?Leu?Val?Ala?Met?Pro?Phe?Ser?Ala?Ile?Ser?Leu?Leu?Asp

120 125 130

ttc?ctg?gat?atg?aaa?cca?ggg?gag?tgg?ctg?atc?caa?aac?tcc?gca?aac 547

Phe?Leu?Asp?Met?Lys?Pro?Gly?Glu?Trp?Leu?Ile?Gln?Asn?Ser?Ala?Asn

135 140 145

ggt?gcc?gtc?ggc?cgc?atg?ctc?gca?cag?ctg?gca?gaa?tcc?cgc?ggc?atc 595

Gly?Ala?Val?Gly?Arg?Met?Leu?Ala?Gln?Leu?Ala?Glu?Ser?Arg?Gly?Ile

150 155 160 165

cat?gtc?gtt?ggt?ctc?gtc?cgc?cgt?gac?gcc?ggt?gtc?caa?gaa?ctc?gct 643

His?Val?Val?Gly?Leu?Val?Arg?Arg?Asp?Ala?Gly?Val?Gln?Glu?Leu?Ala

170 175 180

gct?caa?aac?atc?agc?ggc?gtc?gtt?tcc?act?gag?acc?cca?ggc?tgg?gaa 691

Ala?Gln?Asn?Ile?Ser?Gly?Val?Val?Ser?Thr?Glu?Thr?Pro?Gly?Trp?Glu

185 190 195

aag?cag?gtc?gaa?gac?atc?acc?ggt?ggc?gca?agc?atc?gcc?gtc?gca?ctt 739

Lys?Gln?Val?Glu?Asp?Ile?Thr?Gly?Gly?Ala?Ser?Ile?Ala?Val?Ala?Leu

200 205 210

gat?tcc?gtc?ggt?gga?tcc?tcc?gca?gct?gac?ctg?gtg?aaa?ctg?ctt?ggc 787

Asp?Ser?Val?Gly?Gly?Ser?Ser?Ala?Ala?Asp?Leu?Val?Lys?Leu?Leu?Gly

215 220 225

gaa?ggc?ggc?acc?ctc?gtc?tcc?ttc?ggc?gcc?atg?ggc?aac?cca?atc?atg 835

Glu?Gly?Gly?Thr?Leu?Val?Ser?Phe?Gly?Ala?Met?Gly?Asn?Pro?Ile?Met

230 235 240 245

gaa?atc?cca?tcc?ggc?ccc?gtc?atc?ttc?aag?cac?atc?acc?gtc?aag?ggc 883

Glu?Ile?Pro?Ser?Gly?Pro?Val?Ile?Phe?Lys?His?Ile?Thr?Val?Lys?Gly

250 255 260

ttc?tgg?gga?agc?aaa?gtc?agc?cgc?gaa?atg?cca?gca?gag?aag?aaa?acc 931

Phe?Trp?Gly?Ser?Lys?Val?Ser?Arg?Glu?Met?Pro?Ala?Glu?Lys?Lys?Thr

265 270 275

cag?ttg?ttc?ggc?gag?ctc?att?gcg?cgc?ata?ctt?gat?gga?aca?ttg?acc 979

Gln?Leu?Phe?Gly?Glu?Leu?Ile?Ala?Arg?Ile?Leu?Asp?Gly?Thr?Leu?Thr

280 285 290

ctt?cca?gtt?gat?tcc?acc?ttt?gat?gcc?gct?gac?atc?gtc?tcg?gcc?gtg 1027

Leu?Pro?Val?Asp?Ser?Thr?Phe?Asp?Ala?Ala?Asp?Ile?Val?Ser?Ala?Val

295 300 305

cgc?gcc?tcc?agc?gag?cct?ggc?cgt?gcc?gga?aaa?gtg?ctc?att?cgt?ttc 1075

Arg?Ala?Ser?Ser?Glu?Pro?Gly?Arg?Ala?Gly?Lys?Val?Leu?Ile?Arg?Phe

310 315 320 325

taaacgttta?aggcccatta?gac 1098

<210>406

<211>325

<2l2>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>406

Met?Arg?Ala?Ile?Thr?His?Asn?Thr?Phe?Gly?Asp?Pro?Ala?Asp?Val?Leu

1 5 10 15

Gln?Ile?Thr?Glu?Lys?Glu?Ile?Pro?Thr?Pro?Gly?Pro?Gly?Gln?Val?Arg

20 25 30

Ile?Gin?Val?Thr?Leu?Ala?Thr?Ile?His?Asn?His?Asp?Leu?Trp?Thr?Val

35 40 45

Lys?Gly?Ser?Tyr?Gly?Phe?Val?Pro?Asp?Leu?Pro?Ala?Ala?Ala?Gly?Thr

50 55 60

Glu?Ala?Val?Gly?Ile?Val?Asp?Ala?Leu?Gly?Glu?Gly?Val?Glu?Gly?Leu

65 70 75 80

Gln?Val?Gly?Gln?Arg?Val?Ala?Ser?Gly?Thr?Ser?Phe?Gly?Ile?Trp?Ala

85 90 95

Glu?Tyr?Ala?Leu?Val?Asp?Ala?Ser?Gly?Leu?Ile?Pro?Val?Pro?Glu?Gln

100 105 110

Leu?Ser?Asp?Glu?Ser?Ala?Ala?Gln?Leu?Val?Ala?Met?Pro?Phe?Ser?Ala

115 120 125

Ile?Ser?Leu?Leu?Asp?Phe?Leu?Asp?Met?Lys?Pro?Gly?Glu?Trp?Leu?Ile

130 135 140

Gln?Asn?Ser?Ala?Asn?Gly?Ala?Val?Gly?Arg?Met?Leu?Ala?Gln?Leu?Ala

145 150 155 160

Glu?Ser?Arg?Gly?Ile?His?Val?Val?Gly?Leu?Val?Arg?Arg?Asp?Ala?Gly

165 170 175

Val?Gln?Glu?Leu?Ala?Ala?Gln?Asn?Ile?Ser?Gly?Val?Val?Ser?Thr?Glu

180 185 190

Thr?Pro?Gly?Trp?Glu?Lys?Gln?Val?Glu?Asp?Ile?Thr?Gly?Gly?Ala?Ser

195 200 205

lle?Ala?Val?Ala?Leu?Asp?Ser?Val?Gly?Gly?Ser?Ser?Ala?Ala?Asp?Leu

210 215 220

Val?Lys?Leu?Leu?Gly?Glu?Gly?Gly?Thr?Leu?Val?Ser?Phe?Gly?Ala?Met

225 230 235 240

Gly?Asn?Pro?Ile?Met?Glu?Ile?Pro?Ser?Gly?Pro?Val?Ile?Phe?Lys?His

245 250 255

Ile?Thr?Val?Lys?Gly?Phe?Trp?Gly?Ser?Lys?Val?Ser?Arg?Glu?Met?Pro

260 265 270

Ala?Glu?Lys?Lys?Thr?Gln?Leu?Phe?Gly?Glu?Leu?Ile?Ala?Arg?Ile?Leu

275 280 285

Asp?Gly?Thr?Leu?Thr?Leu?Pro?Val?Asp?Ser?Thr?Phe?Asp?Ala?Ala?Asp

290 295 300

Ile?Val?Ser?Ala?Val?Arg?Ala?Ser?Ser?Glu?Pro?Gly?Arg?Ala?Gly?Lys

305 310 315 320

Val?Leu?Ile?Arg?Phe

325

<210>407

<211>1041

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1018)

<223>RXN01842

<400>407

cacgtcatgg?tctcgcggtg?atcatcttcc?taccgtgaca?ggcaaggccg?caaacggccg?60

tgaccacagg?aaagaaattc?acgaggagag?gaagcacacg?atg?tcg?aag?gta?tac 115

Met?Ser?Lys?Val?Tyr

1 5

gtg?tcc?aac?gag?tac?ggc?ggc?ccg?gaa?aac?cag?gaa?ctg?atc?acc?cgc 163

Val?Ser?Asn?Glu?Tyr?Gly?Gly?Pro?Glu?Asn?Gln?Glu?Leu?Ile?Thr?Arg

10 15 20

aac?acc?ccc?cag?cca?ggc?ccg?gga?gaa?ctc?ggg?gtc?aag?gtc?cac?gcg 211

Asn?Thr?Pro?Gln?Pro?Gly?Pro?Gly?Glu?Leu?Gly?Val?Lys?Val?His?Ala

25 30 35

gcc?ggg?gtc?aac?ccg?ctt?gat?tgg?aag?gtc?cgt?tcc?ggg?gtt?gcc?gga 259

Ala?Gly?Val?Asn?Pro?Leu?Asp?Trp?Lys?Val?Arg?Ser?Gly?Val?Ala?Gly

40 45 50

acc?ccg?cga?gag?ctt?ccg?gca?ccc?ctg?ggc?gag?gag?gcc?tcc?ggg?atc 307

Thr?Pro?Arg?Glu?Leu?Pro?Ala?Pro?Leu?Gly?Glu?Glu?Ala?Ser?Gly?Ile

55 60 65

gtc?acc?gcc?gtt?gga?gac?ggt?gtg?gag?ggc?ttc?gcg?gtc?ggc?gat?ccg 355

Val?Thr?Ala?Val?Gly?Asp?Gly?Val?Glu?Gly?Phe?Ala?Val?Gly?Asp?Pro

70 75 80 85

gtg?ctc?ggc?ctg?gtg?gcc?ccc?ggc?gtc?ggc?gga?tat?gcc?gag?gac?acc 403

Val?Leu?Gly?Leu?Val?Ala?Pro?Gly?Val?Gly?Gly?Tyr?Ala?Glu?Asp?Thr

90 95 100

ctg?ctg?gtg?gca?gag?agt?acc?gtg?cta?aag?ccg?gag?gag?atc?tcg?ttc 451

Leu?Leu?Val?Ala?Glu?Ser?Thr?Val?Leu?Lys?Pro?Glu?Glu?Ile?Ser?Phe

105 110 115

acc?gac?gcc?gcc?gcg?atc?ccg?gtc?gct?ggg?gcg?agc?gcc?tac?gcc?ggc 499

Thr?Asp?Ala?Ala?Ala?Ile?Pro?Val?Ala?Gly?Ala?Ser?Ala?Tyr?Ala?Gly

120 125 130

act?cac?cag?gtc?gag?ctt?gaa?cca?ggc?cag?tcg?ttg?ctg?atc?aat?ggg 547

Thr?His?Gln?Val?Glu?Leu?Glu?Pro?Gly?Gln?Ser?Leu?Leu?Ile?Asn?Gly

135 140 145

gcc?ggt?ggt?ggg?gtc?ggg?ctg?atg?gcc?gcg?cag?atc?gga?cgg?gtc?cac 595

Ala?Gly?Gly?Gly?Val?Gly?Leu?Met?Ala?Ala?Gln?Ile?Gly?Arg?Val?His

150 155 160 165

aag?ttc?cag?gtc?gtc?ggc?gtt?gac?cac?gag?gac?aag?cgc?gag?ctc?atc 643

Lys?Phe?Gln?Val?Val?Gly?Val?Asp?His?Glu?Asp?Lys?Arg?Glu?Leu?Ile

170 175 180

gaa?tcc?acc?ggt?gct?atc?ttc?gtc?gcc?acc?ggc?gac?gcc?gtc?gcg?gag 691

Glu?Ser?Thr?Gly?Ala?Ile?Phe?Val?Ala?Thr?Gly?Asp?Ala?Val?Ala?Glu

185 190 195

cag?gtg?cgt?gcg?ctg?ctc?cct?gac?ggt?gtg?gac?gta?gtc?ttc?gac?cta 739

Gln?Val?Arg?Ala?Leu?Leu?Pro?Asp?Gly?Val?Asp?Val?Val?Phe?Asp?Leu

200 205 210

gtc?ggc?ggg?gag?gcg?ttg?cgg?gtg?gtt?gct?ccc?tta?gcg?aag?aat?ccg 787

Val?Gly?Gly?Glu?Ala?Leu?Arg?Val?Val?Ala?Pro?Leu?Ala?Lys?Asn?Pro

215 220 225

gcg?cac?gtg?atc?tcg?gcg?gct?gat?gct?gcc?acc?gtg?gga?gaa?ctc?ggt 835

Ala?His?Val?Ile?Ser?Ala?Ala?Asp?Ala?Ala?Thr?Val?Gly?Glu?Leu?Gly

230 235 240 245

gga?cag?gtg?ctg?cgc?cgc?acc?ccg?gaa?atg?gtc?gga?cag?atc?acc?ggg 883

Gly?Gln?Val?Leu?Arg?Arg?Thr?Pro?Glu?Met?Val?Gly?Gln?Ile?Thr?Gly

250 255 260

gtg?gtc?cag?tac?ggg?ctg?gtc?gac?ccg?aag?gtc?gat?acg?acc?tac?ccg 931

Val?Val?Gln?Tyr?Gly?Leu?Val?Asp?Pro?Lys?Val?Asp?Thr?Thr?Tyr?Pro

265 270 275

ctg?gaa?cag?gcc?ggt?aag?gcc?ctg?gcc?cac?gtt?gag?cag?ggc?cac?gcc 979

Leu?Glu?Gln?Ala?Gly?Lys?Ala?Leu?Ala?His?Val?Glu?Gln?Gly?His?Ala

280 285 290

cgc?ggc?aag?atc?gtc?ctc?gag?ctc?atc?acc?tcc?cag?gac?taaccagaca 1028

Arg?Gly?Lys?Ile?Val?Leu?Glu?Leu?Ile?Thr?Ser?Gln?Asp

295 300 305

acgcggtgac?ctc 1041

<210>408

<211>306

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>408

Met?Ser?Lys?Val?Tyr?Val?Ser?Asn?Glu?Tyr?Gly?Gly?Pro?Glu?Asn?Gln

1 5 10 15

Glu?Leu?Ile?Thr?Arg?Asn?Thr?Pro?Gln?Pro?Gly?Pro?Gly?Glu?Leu?Gly

20 25 30

Val?Lys?Val?His?Ala?Ala?Gly?Val?Asn?Pro?Leu?Asp?Trp?Lys?Val?Arg

35 40 45

Ser?Gly?Val?Ala?Gly?Thr?Pro?Arg?Glu?Leu?Pro?Ala?Pro?Leu?Gly?Glu

50 55 60

Glu?Ala?Ser?Gly?Ile?Val?Thr?Ala?Val?Gly?Asp?Gly?Val?Glu?Gly?Phe

65 70 75 80

Ala?Val?Gly?Asp?Pro?Val?Leu?Gly?Leu?Val?Ala?Pro?Gly?Val?Gly?Gly

85 90 95

Tyr?Ala?Glu?Asp?Thr?Leu?Leu?Val?Ala?Glu?Ser?Thr?Val?Leu?Lys?Pro

100 105 110

Glu?Glu?Ile?Ser?Phe?Thr?Asp?Ala?Ala?Ala?Ile?Pro?Val?Ala?Gly?Ala

115 120 125

Ser?Ala?Tyr?Ala?Gly?Thr?His?Gln?Val?Glu?Leu?Glu?Pro?Gly?Gln?Ser

130 135 140

Leu?Leu?Ile?Asn?Gly?Ala?Gly?Gly?Gly?Val?Gly?Leu?Met?Ala?Ala?Gln

145 150 155 160

Ile?Gly?Arg?Val?His?Lys?Phe?Gln?Val?Val?Gly?Val?Asp?His?Glu?Asp

165 170 175

Lys?Arg?Glu?Leu?Ile?Glu?Ser?Thr?Gly?Ala?Ile?Phe?Val?Ala?Thr?Gly

180 185 190

Asp?Ala?Val?Ala?Glu?Gln?Val?Arg?Ala?Leu?Leu?Pro?Asp?Gly?Val?Asp

195 200 205

Val?Val?Phe?Asp?Leu?Val?Gly?Gly?Glu?Ala?Leu?Arg?Val?Val?Ala?Pro

210 215 220

Leu?Ala?Lys?Asn?Pro?Ala?His?Val?Ile?Ser?Ala?Ala?Asp?Ala?Ala?Thr

225 230 235 240

Val?Gly?Glu?Leu?Gly?Gly?Gln?Val?Leu?Arg?Arg?Thr?Pro?Glu?Met?Val

245 250 255

Gly?Gln?Ile?Thr?Gly?Val?Val?Gln?Tyr?Gly?Leu?Val?Asp?Pro?Lys?Val

260 265 270

Asp?Thr?Thr?Tyr?Pro?Leu?Glu?Gln?Ala?Gly?Lys?Ala?Leu?Ala?His?Val

275 280 285

Glu?Gln?Gly?His?Ala?Arg?Gly?Lys?Ile?Val?Leu?Glu?Leu?Ile?Thr?Ser

290 295 300

Gln?Asp

305

<210>409

<211>1614

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1591)

<223>RXN00641

<400>409

tgcggaattg?ctcgcaaatg?tcacacaccg?cttcaaagca?aaaacgaaaa?cgacatcgcg?60

gtggcaatac?caacttcttt?tcactctctt?ggaggttcac?atg?tcc?aca?cca?gtt 115

Met?Ser?Thr?Pro?Val

1 5

tca?aat?ttg?gca?agc?gtt?cag?aaa?act?ctg?gac?cat?gcg?ctt?gag?gac 163

Ser?Asn?Leu?Ala?Ser?Val?Gln?Lys?Thr?Leu?Asp?His?Ala?Leu?Glu?Asp

10 15 20

cgc?cct?gaa?gag?gga?atc?gtc?cgc?gtc?aac?cgc?aac?atc?ttc?act?gac 211

Arg?Pro?Glu?Glu?Gly?Ile?Val?Arg?Val?Asn?Arg?Asn?Ile?Phe?Thr?Asp

25 30 35

cct?gag?atc?ttc?gag?ctg?gag?atg?cgc?cac?atc?ttc?gaa?ggc?atc?tgg 259

Pro?Glu?Ile?Phe?Glu?Leu?Glu?Met?Arg?His?Ile?Phe?Glu?Gly?Ile?Trp

40 45 50

atg?gac?atg?gct?cac?gag?tcc?cag?atc?cct?aac?ggt?gga?gac?tac?ttc 307

Met?Asp?Met?Ala?His?Glu?Ser?Gln?Ile?Pro?Asn?Gly?Gly?Asp?Tyr?Phe

55 60 65

acc?acc?tac?att?ggc?tgc?cag?cgg?atc?atg?atc?acc?cgt?tcc?aag?gaa 355

Thr?Thr?Tyr?Ile?Gly?Cys?Gln?Arg?Ile?Met?Ile?Thr?Arg?Ser?Lys?Glu

70 75 80 85

ggc?aca?ctc?aac?ggc?ctg?atc?aac?gcg?tgt?tct?cac?cgt?ggc?gcc?atg 403

Gly?Thr?Leu?Asn?Gly?Leu?Ile?Asn?Ala?Cys?Ser?His?Arg?Gly?Ala?Met

90 95 100

ctc?tgc?cgt?ggc?aag?agt?gac?aac?cgc?acc?tcc?ttg?acc?tgc?cca?ttc 451

Leu?Cys?Arg?Gly?Lys?Ser?Asp?Asn?Arg?Thr?Ser?Leu?Thr?Cys?Pro?Phe

105 110 115

cac?ggc?tgg?cca?ttc?tgc?aac?ggc?ggc?gca?ctg?ctc?aag?gtc?aag?ggc 499

His?Gly?Trp?Pro?Phe?Cys?Asn?Gly?Gly?Ala?Leu?Leu?Lys?Val?Lys?Gly

120 125 130

gaa?aaa?gaa?ggc?gcc?tac?cca?gag?aat?ttc?cgc?acc?gac?ggc?tcc?cac 547

Glu?Lys?Glu?Gly?Ala?Tyr?Pro?Glu?Asn?Phe?Arg?Thr?Asp?Gly?Ser?His

135 140 145

gat?gtg?cgt?cgc?gtt?cct?aag?tta?gag?tcc?tac?cgt?ggc?ttc?ctc?ttc 595

Asp?Val?Arg?Arg?Val?Pro?Lys?Leu?Glu?Ser?Tyr?Arg?Gly?Phe?Leu?Phe

150 155 160 165

ggc?tcc?ctc?aac?gat?gat?gtc?gtt?tct?ttg?gaa?gag?cac?ctc?ggc?gac 643

Gly?Ser?Leu?Asn?Asp?Asp?Val?Val?Ser?Leu?Glu?Glu?His?Leu?Gly?Asp

170 175 180

acc?cgt?acc?gtc?att?gac?atg?ctg?gtt?gac?caa?tcc?cca?gaa?ggc?ctc 691

Thr?Arg?Thr?Val?Ile?Asp?Met?Leu?Val?Asp?Gln?Ser?Pro?Glu?Gly?Leu

185 190 195

gaa?gta?ctg?cgc?gga?tcc?tcc?acc?tac?acc?tac?gac?ggc?aac?tgg?aag 739

Glu?Val?Leu?Arg?Gly?Ser?Ser?Thr?Tyr?Thr?Tyr?Asp?Gly?Asn?Trp?Lys

200 205 210

ctc?cag?acc?gaa?aac?ggt?gca?gac?ggc?tac?cac?gtt?tcc?tcc?acc?cac 787

Leu?Gln?Thr?Glu?Asn?Gly?Ala?Asp?Gly?Tyr?His?Val?Ser?Ser?Thr?His

215 220 225

tgg?aac?tac?gct?gca?acc?acc?tcc?cgc?cgt?ggc?act?ggt?gaa?tcc?gcg 835

Trp?Asn?Tyr?Ala?Ala?Thr?Thr?Ser?Arg?Arg?Gly?Thr?Gly?Glu?Ser?Ala

230 235 240 245

aac?gaa?acc?aag?gca?atg?gac?gct?ggt?acc?tgg?ggc?aag?cag?ggt?ggc 883

Asn?Glu?Thr?Lys?Ala?Met?Asp?Ala?Gly?Thr?Trp?Gly?Lys?Gln?Gly?Gly

250 255 260

gga?tac?ttc?tcc?tac?cct?tac?ggc?cac?atg?ctg?ctg?tgg?atg?tgg?tgg 931

Gly?Tyr?Phe?Ser?Tyr?Pro?Tyr?Gly?His?Met?Leu?Leu?Trp?Met?Trp?Trp

265 270 275

ggc?aac?cca?gaa?gac?cgc?cca?ctg?ttc?gag?cgc?cgc?gac?gag?ttc?aag 979

Gly?Asn?Pro?Glu?Asp?Arg?Pro?Leu?Phe?Glu?Arg?Arg?Asp?Glu?Phe?Lys

280 285 290

aag?gaa?ttc?ggc?gaa?gaa?aag?ggc?gag?ttc?atg?gtt?ggt?gct?tcc?cgc 1027

Lys?Glu?Phe?Gly?Glu?Glu?Lys?Gly?Glu?Phe?Met?Val?Gly?Ala?Ser?Arg

295 300 305

aat?ctg?tgc?ctc?tac?ccc?aat?gtt?tac?ctg?atg?gat?cag?ttc?tcc?tca 1075

Asn?Leu?Cys?Leu?Tyr?Pro?Asn?Val?Tyr?Leu?Met?Asp?Gln?Phe?Ser?Ser

310 315 320 325

cag?atc?cgc?cac?atc?cgc?cca?atc?tca?gtt?gat?cag?acc?gaa?gtc?acc 1123

Gln?Ile?Arg?His?Ile?Arg?Pro?Ile?Ser?Val?Asp?Gln?Thr?Glu?Val?Thr

330 335 340

atc?tac?tgc?atc?gca?cct?aag?ggc?gag?tcc?gcg?gaa?gca?cgt?gca?aac 1171

Ile?Tyr?Cys?Ile?Ala?Pro?Lys?Gly?Glu?Ser?Ala?Glu?Ala?Arg?Ala?Asn

345 350 355

cgc?atc?cgc?cag?tac?gaa?gac?ttc?ttc?aac?gca?acg?ggc?atg?gca?acc 1219

Arg?Ile?Arg?Gln?Tyr?Glu?Asp?Phe?Phe?Asn?Ala?Thr?Gly?Met?Ala?Thr

360 365 370

cca?gat?gac?ctg?gag?gaa?ttc?cgc?tcc?tgc?cag?aag?acc?tac?cag?gca 1267

Pro?Asp?Asp?Leu?Glu?Glu?Phe?Arg?Ser?Cys?Gln?Lys?Thr?Tyr?Gln?Ala

375 380 385

tct?gcc?ttc?cca?tgg?aat?gac?atg?acc?cgc?ggt?ttg?ggc?cac?cag?gta 1315

Ser?Ala?Phe?Pro?Trp?Asn?Asp?Met?Thr?Arg?Gly?Leu?Gly?His?Gln?Val

390 395 400 405

cag?gga?cca?aac?gag?gtt?gcc?aag?ggc?cta?ggc?atg?aac?gaa?gtt?ctt 1363

Gln?Gly?Pro?Asn?Glu?Val?Ala?Lys?Gly?Leu?Gly?Met?Asn?Glu?Val?Leu

410 415 420

tcc?tcc?gga?gca?cgc?acc?gaa?gat?gaa?ggc?ctc?tac?cca?atc?cag?cac 1411

Ser?Ser?Gly?Ala?Arg?Thr?Glu?Asp?Glu?Gly?Leu?Tyr?Pro?Ile?Gln?His

425 430 435

ggc?ttc?tgg?cat?gaa?ctc?atg?cag?gag?gct?gtg?aat?aag?cag?agc?atc 1459

Gly?Phe?Trp?His?Glu?Leu?Met?Gln?Glu?Ala?Val?Asn?Lys?Gln?Ser?Ile

440 445 450

aag?gaa?aag?gaa?ttg?gct?gac?gat?acc?gct?tct?tcc?ctt?gcc?acc?gta 1507

Lys?Glu?Lys?Glu?Leu?Ala?Asp?Asp?Thr?Ala?Ser?Ser?Leu?Ala?Thr?Val

455 460 465

gct?gca?gcc?aaa?atc?cgt?gag?gaa?gca?aag?gca?gcc?gcg?aag?tcc?gac 1555

Ala?Ala?Ala?Lys?Ile?Arg?Glu?Glu?Ala?Lys?Ala?Ala?Ala?Lys?Ser?Asp

470 475 480 485

gct?gga?gag?cct?cgc?cgc?cgt?cgt?cgc?acc?cgc?ggt?tagtcgtcga 1601

Ala?Gly?Glu?Pro?Arg?Arg?Arg?Arg?Arg?Thr?Arg?Gly

490 495

aaagcaaaaa?atc 1614

<210>410

<211>497

<2l2>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>410

Met?Ser?Thr?Pro?Val?Ser?Asn?Leu?Ala?Ser?Val?Gln?Lys?Thr?Leu?Asp

1 5 10 15

His?Ala?Leu?Glu?Asp?Arg?Pro?Glu?Glu?Gly?Ile?Val?Arg?Val?Asn?Arg

20 25 30

Asn?Ile?Phe?Thr?Asp?Pro?Glu?Ile?Phe?Glu?Leu?Glu?Met?Arg?His?Ile

35 40 45

Phe?Glu?Gly?Ile?Trp?Met?Asp?Met?Ala?His?Glu?Ser?Gln?Ile?Pro?Asn

50 55 60

Gly?Gly?Asp?Tyr?Phe?Thr?Thr?Tyr?Ile?Gly?Cys?Gln?Arg?Ile?Met?Ile

65 70 75 80

Thr?Arg?Ser?Lys?Glu?Gly?Thr?Leu?Asn?Gly?Leu?Ile?Asn?Ala?Cys?Ser

85 90 95

His?Arg?Gly?Ala?Met?Leu?Cys?Arg?Gly?Lys?Ser?Asp?Asn?Arg?Thr?Ser

100 105 110

Leu?Thr?Cys?Pro?Phe?His?Gly?Trp?Pro?Phe?Cys?Asn?Gly?Gly?Ala?Leu

115 120 125

Leu?Lys?Val?Lys?Gly?Glu?Lys?Glu?Gly?Ala?Tyr?Pro?Glu?Asn?Phe?Arg

130 135 140

Thr?Asp?Gly?Ser?His?Asp?Val?Arg?Arg?Val?Pro?Lys?Leu?Glu?Ser?Tyr

145 150 155 160

Arg?Gly?Phe?Leu?Phe?Gly?Ser?Leu?Asn?Asp?Asp?Val?Val?Ser?Leu?Glu

165 170 175

Glu?His?Leu?Gly?Asp?Thr?Arg?Thr?Val?Ile?Asp?Met?Leu?Val?Asp?Gln

180 185 190

Ser?Pro?Glu?Gly?Leu?Glu?Val?Leu?Arg?Gly?Ser?Ser?Thr?Tyr?Thr?Tyr

195 200 205

Asp?Gly?Asn?Trp?Lys?Leu?Gln?Thr?Glu?Asn?Gly?Ala?Asp?Gly?Tyr?His

210 215 220

Val?Ser?Ser?Thr?His?Trp?Asn?Tyr?Ala?Ala?Thr?Thr?Ser?Arg?Arg?Gly

225 230 235 240

Thr?Gly?Glu?Ser?Ala?Asn?Glu?Thr?Lys?Ala?Met?Asp?Ala?Gly?Thr?Trp

245 250 255

Gly?Lys?Gln?Gly?Gly?Gly?Tyr?Phe?Ser?Tyr?Pro?Tyr?Gly?His?Met?Leu

260 265 270

Leu?Trp?Met?Trp?Trp?Gly?Asn?Pro?Glu?Asp?Arg?Pro?Leu?Phe?Glu?Arg

275 280 285

Arg?Asp?Glu?Phe?Lys?Lys?Glu?Phe?Gly?Glu?Glu?Lys?Gly?Glu?Phe?Met

290 295 300

Val?Gly?Ala?Ser?Arg?Asn?Leu?Cys?Leu?Tyr?Pro?Asn?Val?Tyr?Leu?Met

305 310 315 320

Asp?Gln?Phe?Ser?Ser?Gln?Ile?Arg?His?Ile?Arg?Pro?Ile?Ser?Val?Asp

325 330 335

Gln?Thr?Glu?Val?Thr?Ile?Tyr?Cys?Ile?Ala?Pro?Lys?Gly?Glu?Ser?Ala

340 345 350

Glu?Ala?Arg?Ala?Asn?Arg?Ile?Arg?Gln?Tyr?Glu?Asp?Phe?Phe?Asn?Ala

355 360 365

Thr?Gly?Met?Ala?Thr?Pro?Asp?Asp?Leu?Glu?Glu?Phe?Arg?Ser?Cys?Gln

370 375 380

Lys?Thr?Tyr?Gln?Ala?Ser?Ala?Phe?Pro?Trp?Asn?Asp?Met?Thr?Arg?Gly

385 390 395 400

Leu?Gly?His?Gln?Val?Gln?Gly?Pro?Asn?Glu?Val?Ala?Lys?Gly?Leu?Gly

405 410 415

Met?Asn?Glu?Val?Leu?Ser?Ser?Gly?Ala?Arg?Thr?Glu?Asp?Glu?Gly?Leu

420 425 430

Tyr?Pro?Ile?Gln?His?Gly?Phe?Trp?His?Glu?Leu?Met?Gln?Glu?Ala?Val

435 440 445

Asn?Lys?Gln?Ser?Ile?Lys?Glu?Lys?Glu?Leu?Ala?Asp?Asp?Thr?Ala?Ser

450 455 460

Ser?Leu?Ala?Thr?Val?Ala?Ala?Ala?Lys?Ile?Arg?Glu?Glu?Ala?Lys?Ala

465 470 475 480

Ala?Ala?Lys?Ser?Asp?Ala?Gly?Glu?Pro?Arg?Arg?Arg?Arg?Arg?Thr?Arg

485 490 495

Gly

<210>411

<211>1166

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(16)..(1143)

<223>RXN01993

<400>411

ctttaggagt?tcacc?atg?aca?ctg?tcc?gaa?cgc?aag?ctc?acc?acc?acc?gcc 51

Met?Thr?Leu?Ser?Glu?Arg?Lys?Leu?Thr?Thr?Thr?Ala

1 5 10

aag?att?ctt?ccc?cac?cca?ctc?aac?gcc?tgg?tac?gtc?gcc?gct?tgg?gat 99

Lys?Ile?Leu?Pro?His?Pro?Leu?Asn?Ala?Trp?Tyr?Val?Ala?Ala?Trp?Asp

15 20 25

tat?gaa?gtc?aca?tct?aaa?aag?ccc?atg?gcc?agg?aca?atc?gcc?aac?aaa 147

Tyr?Glu?Val?Thr?Ser?Lys?Lys?Pro?Met?Ala?Arg?Thr?Ile?Ala?Asn?Lys

30 35 40

cca?ctc?gct?ttg?tac?cgc?acc?aaa?gat?ggc?cga?gcc?gtt?gcc?ctt?gca 195

Pro?Leu?Ala?Leu?Tyr?Arg?Thr?Lys?Asp?Gly?Arg?Ala?Val?Ala?Leu?Ala

45 50 55 60

gac?gcc?tgc?tgg?cac?cgc?ctc?gca?ccg?cta?tcc?aag?gga?aaa?ctc?gtg 243

Asp?Ala?Cys?Trp?His?Arg?Leu?Ala?Pro?Leu?Ser?Lys?Gly?Lys?Leu?Val

65 70 75

ggc?aca?gac?gga?atc?caa?tgc?cct?tat?cac?ggc?ttg?gag?tac?aac?tcc 291

Gly?Thr?Asp?Gly?Ile?Gln?Cys?Pro?Tyr?His?Gly?Leu?Glu?Tyr?Asn?Ser

80 85 90

gcg?ggc?cgc?tgc?atg?aaa?atg?ccc?gcg?cag?gaa?acc?ctc?aac?ccg?tca 339

Ala?Gly?Arg?Cys?Met?Lys?Met?Pro?Ala?Gln?Glu?Thr?Leu?Asn?Pro?Ser

95 100 105

gca?gcc?gtc?aac?tcc?tac?ccc?gtg?gtg?gaa?gcc?cac?cgc?ttt?gtg?tgg 387

Ala?Ala?Val?Asn?Ser?Tyr?Pro?Val?Val?Glu?Ala?His?Arg?Phe?Val?Trp

110 115 120

gtg?tgg?ctg?ggc?gat?ccc?aca?ttg?gca?gat?ccc?acc?caa?gta?ccc?gat 435

Val?Trp?Leu?Gly?Asp?Pro?Thr?Leu?Ala?Asp?Pro?Thr?Gln?Val?Pro?Asp

125 130 135 140

atg?cac?cag?atg?agc?cac?ccc?gaa?tgg?gca?ggc?gat?gga?cgc?acc?atc 483

Met?His?Gln?Met?Ser?His?Pro?Glu?Trp?Ala?Gly?Asp?Gly?Arg?Thr?Ile

145 150 155

tcc?gct?gac?tgc?aac?tac?caa?tta?gtg?ctg?gac?aac?ttg?atg?gac?ctc 531

Ser?Ala?Asp?Cys?Asn?Tyr?Gln?Leu?Val?Leu?Asp?Asn?Leu?Met?Asp?Leu

160 165 170

acc?cac?gaa?gag?ttc?gtg?cac?tcc?tcc?agc?atc?gga?caa?gac?gaa?ctt 579

Thr?His?Glu?Glu?Phe?Val?His?Ser?Ser?Ser?Ile?Gly?Gln?Asp?Glu?Leu

175 180 185

agt?gaa?tca?gag?ttc?gtg?gtc?acc?cac?act?gaa?gat?tcc?gtg?acg?gtc 627

Ser?Glu?Ser?Glu?Phe?Val?Val?Thr?His?Thr?Glu?Asp?Ser?Val?Thr?Val

190 195 200

acc?cgc?tgg?atg?cat?gac?ata?gat?gca?cca?ccg?ttt?tgg?caa?aag?aac 675

Thr?Arg?Trp?Met?His?Asp?Ile?Asp?Ala?Pro?Pro?Phe?Trp?Gln?Lys?Asn

205 210 215 220

atg?aat?gat?aag?ttc?cca?gga?ttt?gaa?ggc?aag?gtg?gat?cgt?tgg?cag 723

Met?Asn?Asp?Lys?Phe?Pro?Gly?Phe?Glu?Gly?Lys?Val?Asp?Arg?Trp?Gln

225 230 235

atc?atc?cac?tac?tac?tac?cct?tcc?acc?atc?tgc?att?gat?gtt?ggt?gta 771

Ile?Ile?His?Tyr?Tyr?Tyr?Pro?Ser?Thr?Ile?Cys?Ile?Asp?Val?Gly?Val

240 245 250

gca?aag?gct?gga?act?ggc?gcg?cag?gaa?ggc?gac?cgc?agc?cag?ggc?gtt 819

Ala?Lys?Ala?Gly?Thr?Gly?Ala?Gln?Glu?Gly?Asp?Arg?Ser?Gln?Gly?Val

255 260 265

aat?ggg?tat?gtc?atg?aac?acc?att?acc?cca?gat?tca?gat?cgt?tcc?tct 867

Asn?Gly?Tyr?Val?Met?Asn?Thr?Ile?Thr?Pro?Asp?Ser?Asp?Arg?Ser?Ser

270 275 280

cat?tac?ttc?tgg?gca?ttc?atg?cgc?aac?tac?cgc?ctg?gaa?agc?caa?acc 915

His?Tyr?Phe?Trp?Ala?Phe?Met?Arg?Asn?Tyr?Arg?Leu?Glu?Ser?Gln?Thr

285 290 295 300

atc?acc?acc?cag?ctg?cgc?gac?ggt?gta?tcc?ggt?gta?ttc?aaa?gaa?gac 963

Ile?Thr?Thr?Gln?Leu?Arg?Asp?Gly?Val?Ser?Gly?Val?Phe?Lys?Glu?Asp

305 310 315

gaa?gac?atg?ctg?acc?gct?cag?caa?gat?gcc?atc?gac?gcc?aac?acc?gac 1011

Glu?Asp?Met?Leu?Thr?Ala?Gln?Gln?Asp?Ala?Ile?Asp?Ala?Asn?Thr?Asp

320 325 330

tac?gag?ttt?tac?agc?ctc?aac?att?gat?gcc?ggt?ggc?atg?tgg?gtg?cgc 1059

Tyr?Glu?Phe?Tyr?Ser?Leu?Asn?Ile?Asp?Ala?Gly?Gly?Met?Trp?Val?Arg

335 340 345

cga?atc?ctc?gag?gaa?gca?ctc?tcc?aag?gaa?ggc?cga?ctg?gat?atc?ccc 1107

Arg?Ile?Leu?Glu?Glu?Ala?Leu?Ser?Lys?Glu?Gly?Arg?Leu?Asp?Ile?Pro

350 355 360

acc?aca?ttc?ccc?cgc?gca?aca?ccg?aag?ccg?gag?gca?taaaccatga 1153

Thr?Thr?Phe?Pro?Arg?Ala?Thr?Pro?Lys?Pro?Glu?Ala

365 370 375

actcgcaatg?gca 1166

<210>412

<211>376

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>412

Met?Thr?Leu?Ser?Glu?Arg?Lys?Leu?Thr?Thr?Thr?Ala?Lys?Ile?Leu?Pro

1 5 10 15

His?Pro?Leu?Asn?Ala?Trp?Tyr?Val?Ala?Ala?Trp?Asp?Tyr?Glu?Val?Thr

20 25 30

Ser?Lys?Lys?Pro?Met?Ala?Arg?Thr?Ile?Ala?Asn?Lys?Pro?Leu?Ala?Leu

35 40 45

Tyr?Arg?Thr?Lys?Asp?Gly?Arg?Ala?Val?Ala?Leu?Ala?Asp?Ala?Cys?Trp

50 55 60

His?Arg?Leu?Ala?Pro?Leu?Ser?Lys?Gly?Lys?Leu?Val?Gly?Thr?Asp?Gly

65 70 75 80

Ile?Gln?Cys?Pro?Tyr?His?Gly?Leu?Glu?Tyr?Asn?Ser?Ala?Gly?Arg?Cys

85 90 95

Met?Lys?Met?Pro?Ala?Gln?Glu?Thr?Leu?Asn?Pro?Ser?Ala?Ala?Val?Asn

100 105 110

Ser?Tyr?Pro?Val?Val?Glu?Ala?His?Arg?Phe?Val?Trp?Val?Trp?Leu?Gly

115 120 125

Asp?Pro?Thr?Leu?Ala?Asp?Pro?Thr?Gln?Val?Pro?Asp?Met?His?Gln?Met

130 135 140

Ser?His?Pro?Glu?Trp?Ala?Gly?Asp?Gly?Arg?Thr?Ile?Ser?Ala?Asp?Cys

145 150 155 160

Asn?Tyr?Gln?Leu?Val?Leu?Asp?Asn?Leu?Met?Asp?Leu?Thr?His?Glu?Glu

165 170 175

Phe?Val?His?Ser?Ser?Ser?lle?Gly?Gln?Asp?Glu?Leu?Ser?Glu?Ser?Glu

180 185 190

Phe?Val?Val?Thr?His?Thr?Glu?Asp?Ser?Val?Thr?Val?Thr?Arg?Trp?Met

195 200 205

His?Asp?Ile?Asp?Ala?Pro?Pro?Phe?Trp?Gln?Lys?Asn?Met?Asn?Asp?Lys

210 215 220

Phe?Pro?Gly?Phe?Glu?Gly?Lys?Val?Asp?Arg?Trp?Gln?Ile?Ile?His?Tyr

225 230 235 240

Tyr?Tyr?Pro?Ser?Thr?Ile?Cys?Ile?Asp?Val?Gly?Val?Ala?Lys?Ala?Gly

245 250 255

Thr?Gly?Ala?Gln?Glu?Gly?Asp?Arg?Ser?Gln?Gly?Val?Asn?Gly?Tyr?Val

260 265 270

Met?Asn?Thr?Ile?Thr?Pro?Asp?Ser?Asp?Arg?Ser?Ser?His?Tyr?Phe?Trp

275 280 285

Ala?Phe?Met?Arg?Asn?Tyr?Arg?Leu?Glu?Ser?Gln?Thr?Ile?Thr?Thr?Gln

290 295 300

Leu?Arg?Asp?Gly?Val?Ser?Gly?Val?Phe?Lys?Glu?Asp?Glu?Asp?Met?Leu

305 310 315 320

Thr?Ala?Gln?Gln?Asp?Ala?Ile?Asp?Ala?Asn?Thr?Asp?Tyr?Glu?Phe?Tyr

325 330 335

Ser?Leu?Asn?Ile?Asp?Ala?Gly?Gly?Met?Trp?Val?Arg?Arg?Ile?Leu?Glu

340 345 350

Glu?Ala?Leu?Ser?Lys?Glu?Gly?Arg?Leu?Asp?Ile?Pro?Thr?Thr?Phe?Pro

355 360 365

Arg?Ala?Thr?Pro?Lys?Pro?Glu?Ala

370 375

<210>413

<211>816

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(793)

<223>RXN00658

<400>413

cattgacacc?cacaggttta?ccagcatcac?ggaaagtttg?gatggatttt?tactccggcc?60

acaacgtctg?gctggaagct?cagccacgtg?ctttctggtc?gtg?cgc?cac?gac?gag 115

Val?Arg?His?Asp?Glu

1 5

cac?tac?cca?gct?gcg?gca?aac?ctc?att?gct?ttc?gat?aag?gga?tgg?tcc 163

His?Tyr?Pro?Ala?Ala?Ala?Asn?Leu?Ile?Ala?Phe?Asp?Lys?Gly?Trp?Ser

10 15 20

acc?ctc?atc?gcc?cct?cag?ctg?gaa?gat?cca?gag?gcg?gag?gag?ttc?acc 211

Thr?Leu?Ile?Ala?Pro?Gln?Leu?Glu?Asp?Pro?Glu?Ala?Glu?Glu?Phe?Thr

25 30 35

gcc?gga?ttc?ctc?acc?gaa?tac?cag?gac?aat?ctg?atc?act?gcg?ggc?atg 259

Ala?Gly?Phe?Leu?Thr?Glu?Tyr?Gln?Asp?Asn?Leu?Ile?Thr?Ala?Gly?Met

40 45 50

gag?cac?cag?gcg?ctc?gcg?agc?ggc?ttc?ccg?gtg?ggg?cgt?cgc?ttc?aag 307

Glu?His?Gln?Ala?Leu?Ala?Ser?Gly?Phe?Pro?Val?Gly?Arg?Arg?Phe?Lys

55 60 65

tcc?gat?att?gct?tta?cga?cgc?tgc?gat?gcg?gtg?acc?acc?cac?atc?ggc 355

Ser?Asp?Ile?Ala?Leu?Arg?Arg?Cys?Asp?Ala?Val?Thr?Thr?His?Ile?Gly

70 75 80 85

cac?gaa?cac?tcc?gcc?gat?ggt?cac?tgg?agg?atc?tac?gta?ttc?gct?ggc 403

His?Glu?His?Ser?Ala?Asp?Gly?His?Trp?Arg?Ile?Tyr?Val?Phe?Ala?Gly

90 95 100

caa?gcc?acc?cca?caa?gat?tcc?gag?tct?gca?ctg?aac?aag?tgg?gcg?cag 451

Gln?Ala?Thr?Pro?Gln?Asp?Ser?Glu?Ser?Ala?Leu?Asn?Lys?Trp?Ala?Gln

105 110 115

tgg?atg?gag?gaa?agc?gaa?gac?tca?cca?ctc?aac?cgc?ttc?acc?cca?gaa 499

Trp?Met?Glu?Glu?Ser?Glu?Asp?Ser?Pro?Leu?Asn?Arg?Phe?Thr?Pro?Glu

120 125 130

gcc?ggc?gac?cgc?aac?gca?gtc?ttc?gat?atc?aag?gct?acc?tac?cag?cag 547

Ala?Gly?Asp?Arg?Asn?Ala?Val?Phe?Asp?Ile?Lys?Ala?Thr?Tyr?Gln?Gln

135 140 145

cat?tac?cac?tcc?ttc?gac?ctg?ttc?gat?gcg?cca?gag?gtc?ttc?ttc?cca 595

His?Tyr?His?Ser?Phe?Asp?Leu?Phe?Asp?Ala?Pro?Glu?Val?Phe?Phe?Pro

150 155 160 165

cga?gtt?gga?cca?tac?aag?ctg?caa?aac?ctc?gaa?aac?gtt?tgg?acc?gca 643

Arg?Val?Gly?Pro?Tyr?Lys?Leu?Gln?Asn?Leu?Glu?Asn?Val?Trp?Thr?Ala

170 175 180

ctg?gat?tcc?caa?gac?atc?ttt?gag?tcc?cgt?ggc?atc?agt?cgc?gat?ggc 691

Leu?Asp?Ser?Gln?Asp?Ile?Phe?Glu?Ser?Arg?Gly?Ile?Ser?Arg?Asp?Gly

185 190 195

gca?att?gtt?gtc?gtt?cgc?cca?gac?cag?tac?gtc?gca?gca?gtc?ctc?cca 739

Ala?Ile?Val?Val?Val?Arg?Pro?Asp?Gln?Tyr?Val?Ala?Ala?Val?Leu?Pro

200 205 210

ctc?gaa?gac?acc?gca?gca?ctg?gct?gag?ttc?ttc?aat?ggc?aat?ctg?ctt 787

Leu?Glu?Asp?Thr?Ala?Ala?Leu?Ala?Glu?Phe?Phe?Asn?Gly?Asn?Leu?Leu

215 220 225

gag?cca?taaaccctaa?attctaggaa?cga 816

Glu?Pro

230

<210>414

<211>231

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>414

Val?Arg?His?Asp?Glu?His?Tyr?Pro?Ala?Ala?Ala?Asn?Leu?Ile?Ala?Phe

1 5 10 15

Asp?Lys?Gly?Trp?Ser?Thr?Leu?Ile?Ala?Pro?Gln?Leu?Glu?Asp?Pro?Glu

20 25 30

Ala?Glu?Glu?Phe?Thr?Ala?Gly?Phe?Leu?Thr?Glu?Tyr?Gln?Asp?Asn?Leu

35 40 45

Ile?Thr?Ala?Gly?Met?Glu?His?Gln?Ala?Leu?Ala?Ser?Gly?Phe?Pro?Val

50 55 60

Gly?Arg?Arg?Phe?Lys?Ser?Asp?Ile?Ala?Leu?Arg?Arg?Cys?Asp?Ala?Val

65 70 75 80

Thr?Thr?His?Ile?Gly?His?Glu?His?Ser?Ala?Asp?Gly?His?Trp?Arg?Ile

85 90 95

Tyr?Val?Phe?Ala?Gly?Gln?Ala?Thr?Pro?Gln?Asp?Ser?Glu?Ser?Ala?Leu

100 105 110

Asn?Lys?Trp?Ala?Gln?Trp?Met?Glu?Glu?Ser?Glu?Asp?Ser?Pro?Leu?Asn

115 120 125

Arg?Phe?Thr?Pro?Glu?Ala?Gly?Asp?Arg?Asn?Ala?Val?Phe?Asp?Ile?Lys

130 135 140

Ala?Thr?Tyr?Gln?Gln?His?Tyr?His?Ser?Phe?Asp?Leu?Phe?Asp?Ala?Pro

145 150 155 160

Glu?Val?Phe?Phe?Pro?Arg?Val?Gly?Pro?Tyr?Lys?Leu?Gln?Asn?Leu?Glu

165 170 175

Asn?Val?Trp?Thr?Ala?Leu?Asp?Ser?Gln?Asp?Ile?Phe?Glu?Ser?Arg?Gly

180 185 190

Ile?Ser?Arg?Asp?Gly?Ala?Ile?Val?Val?Val?Arg?Pro?Asp?Gln?Tyr?Val

195 200 205

Ala?Ala?Val?Leu?Pro?Leu?Glu?Asp?Thr?Ala?Ala?Leu?Ala?Glu?Phe?Phe

210 215 220

Asn?Gly?Asn?Leu?Leu?Glu?Pro

225 230

<210>415

<211>1008

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(985)

<223>RXN00178

<400>415

gcgaataatc?cacggacggt?cacagaagaa?aacctcactg?cgctgcttac?cacagcgctc?60

aacggcgacg?atccagcaac?tttgaattaa?ggagaccaac?atg?act?att?tca?gca 115

Met?Thr?Ile?Ser?Ala

1 5

caa?cag?caa?gca?gtg?gaa?gaa?gac?ctt?gta?gag?cgc?gta?ctc?gca?tct 163

Gln?Gln?Gln?Ala?Val?Glu?Glu?Asp?Leu?Val?Glu?Arg?Val?Leu?Ala?Ser

10 15 20

ttt?gat?tcg?tgt?gaa?aac?cct?cgc?ctc?aaa?cta?gtg?atg?aaa?tcc?ctg 211

Phe?Asp?Ser?Cys?Glu?Asn?Pro?Arg?Leu?Lys?Leu?Val?Met?Lys?Ser?Leu

25 30 35

act?gtg?cat?ctc?cat?gat?ttc?atc?cgc?gat?gtt?cga?ctc?act?gaa?gaa 259

Thr?Val?His?Leu?His?Asp?Phe?Ile?Arg?Asp?Val?Arg?Leu?Thr?Glu?Glu

40 45 50

gag?tgg?aac?tac?gcc?att?gat?ttc?ctc?acc?aag?gtt?ggg?cat?atc?acc 307

Glu?Trp?Asn?Tyr?Ala?Ile?Asp?Phe?Leu?Thr?Lys?Val?Gly?His?Ile?Thr

55 60 65

gac?gat?aag?cgc?caa?gaa?ttc?gtg?ttg?ctc?tct?gac?acc?ttg?ggt?gca 355

Asp?Asp?Lys?Arg?Gln?Glu?Phe?Val?Leu?Leu?Ser?Asp?Thr?Leu?Gly?Ala

70 75 80 85

tcc?atg?cag?acc?atc?gct?gtt?aat?aac?gaa?gca?tat?gaa?gac?gct?acc 403

Ser?Met?Gln?Thr?Ile?Ala?Val?Asn?Asn?Glu?Ala?Tyr?Glu?Asp?Ala?Thr

90 95 100

gaa?gca?aca?gtc?ttt?ggc?ccc?ttc?ttt?gtc?gat?gat?gcg?cca?ctg?gtc 451

Glu?Ala?Thr?Val?Phe?Gly?Pro?Phe?Phe?Val?Asp?Asp?Ala?Pro?Leu?Val

105 110 115

caa?aac?gga?gat?gac?att?gcc?ttt?ggc?gca?gtc?ggc?cag?ccg?gca?tgg 499

Gln?Asn?Gly?Asp?Asp?Ile?Ala?Phe?Gly?Ala?Val?Gly?Gln?Pro?Ala?Trp

120 125 130

gtg?gag?gga?acg?gtc?aaa?gac?act?gaa?gga?aac?ccc?att?ccc?aat?gca 547

Val?Glu?Gly?Thr?Val?Lys?Asp?Thr?Glu?Gly?Asn?Pro?Ile?Pro?Asn?Ala

135 140 145

cgc?att?gaa?gta?tgg?gaa?tgc?gat?gaa?gat?gga?ctt?tat?gat?gtg?caa 595

Arg?Ile?Glu?Val?Trp?Glu?Cys?Asp?Glu?Asp?Gly?Leu?Tyr?Asp?Val?Gln

150 155 160 165

tac?gcc?gat?gag?cgc?agt?gct?gga?cgc?gca?cac?ctg?tat?tca?gat?gaa 643

Tyr?Ala?Asp?Glu?Arg?Ser?Ala?Gly?Arg?Ala?His?Leu?Tyr?Ser?Asp?Glu

170 175 180

aac?ggc?gaa?tac?cac?ttc?tgg?gga?cta?act?ccc?gtg?cca?tat?ccc?atc 691

Asn?Gly?Glu?Tyr?His?Phe?Trp?Gly?Leu?Thr?Pro?Val?Pro?Tyr?Pro?Ile

185 190 195

cca?cac?gat?ggt?cca?gta?gga?caa?atg?ctc?caa?gca?gtt?ggt?cgt?tcc 739

Pro?His?Asp?Gly?Pro?Val?Gly?Gln?Met?Leu?Gln?Ala?Val?Gly?Arg?Ser

200 205 210

ccc?gtt?cgt?tgc?gcg?cac?cta?cac?ttc?atg?gtg?act?gcg?cca?gag?aag 787

Pro?Val?Arg?Cys?Ala?His?Leu?His?Phe?Met?Val?Thr?Ala?Pro?Glu?Lys

215 220 225

cga?acc?ttg?gta?acc?cat?atc?ttc?gtt?gag?ggc?gat?ccg?cag?cta?gag 835

Arg?Thr?Leu?Val?Thr?His?Ile?Phe?Val?Glu?Gly?Asp?Pro?Gln?Leu?Glu

230 235 240 245

atc?ggc?gat?tcc?gtg?ttt?ggc?gtg?aag?gac?tca?ctg?att?aag?aaa?ttc 883

Ile?Gly?Asp?Ser?Val?Phe?Gly?Val?Lys?Asp?Ser?Leu?Ile?Lys?Lys?Phe

250 255 260

gtt?gag?caa?cct?gca?gga?acc?gca?act?cca?gat?ggt?cgc?gat?gtg?ggt 931

Val?Glu?Gln?Pro?Ala?Gly?Thr?Ala?Thr?Pro?Asp?Gly?Arg?Asp?Val?Gly

265 270 275

gat?caa?acc?tgg?gca?cgc?aca?cgt?ttt?gat?att?gtg?ctc?gcc?ccc?ggc 979

Asp?Gln?Thr?Trp?Ala?Arg?Thr?Arg?Phe?Asp?Ile?Val?Leu?Ala?Pro?Gly

280 285 290

aat?gtc?taagtagaag?cagcaaaaaa?cca 1008

Asn?Val

295

<210>416

<211>295

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>416

Met?Thr?Ile?Ser?Ala?Gln?G?ln?Gln?Ala?Val?Glu?Glu?Asp?Leu?Val?Glu

1 5 10 15

Arg?Val?Leu?Ala?Ser?Phe?Asp?Ser?Cys?Glu?Asn?Pro?Arg?Leu?Lys?Leu

20 25 30

Val?Met?Lys?Ser?Leu?Thr?Val?His?Leu?His?Asp?Phe?Ile?Arg?Asp?Val

35 40 45

Arg?Leu?Thr?Glu?Glu?Glu?Trp?Asn?Tyr?Ala?Ile?Asp?Phe?Leu?Thr?Lys

50 55 60

Val?Gly?His?Ile?Thr?Asp?Asp?Lys?Arg?Gln?Glu?Phe?Val?Leu?Leu?Ser

65 70 75 80

Asp?Thr?Leu?Gly?Ala?Ser?Met?Gln?Thr?Ile?Ala?Val?Asn?Asn?Glu?Ala

85 90 95

Tyr?Glu?Asp?Ala?Thr?Glu?Ala?Thr?Val?Phe?Gly?Pro?Phe?Phe?Val?Asp

100 105 110

Asp?Ala?Pro?Leu?Val?Gln?Asn?Gly?Asp?Asp?Ile?Ala?Phe?Gly?Ala?Val

115 120 125

Gly?Gln?Pro?Ala?Trp?Val?Glu?Gly?Thr?Val?Lys?Asp?Thr?Glu?Gly?Asn

130 135 140

Pro?Ile?Pro?Asn?Ala?Arg?Ile?Glu?Val?Trp?Glu?Cys?Asp?Glu?Asp?Gly

145 150 155 160

Leu?Tyr?Asp?Val?Gln?Tyr?Ala?Asp?Glu?Arg?Ser?Ala?Gly?Arg?Ala?His

165 170 175

Leu?Tyr?Ser?Asp?Glu?Asn?Gly?Glu?Tyr?His?Phe?Trp?Gly?Leu?Thr?Pro

180 185 190

Val?Pro?Tyr?Pro?Ile?Pro?His?Asp?Gly?Pro?Val?Gly?Gln?Met?Leu?Gln

195 200 205

Ala?Val?Gly?Arg?Ser?Pro?Val?Arg?Cys?Ala?His?Leu?His?Phe?Met?Val

210 215 220

Thr?Ala?Pro?Glu?Lys?Arg?Thr?Leu?Val?Thr?His?Ile?Phe?Val?Glu?Gly

225 230 235 240

Asp?Pro?Gln?Leu?Glu?Ile?Gly?Asp?Ser?Val?Phe?Gly?Val?Lys?Asp?Ser

245 250 255

Leu?Ile?Lys?Lys?Phe?Val?Glu?Gln?Pro?Ala?Gly?Thr?Ala?Thr?Pro?Asp

260 265 270

Gly?Arg?Asp?Val?Gly?Asp?Gln?Thr?Trp?Ala?Arg?Thr?Arg?Phe?Asp?Ile

275 280 285

Val?Leu?Ala?Pro?Gly?Asn?Val

290 295

<210>417

<211>735

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(712)

<223>RXN01461

<400>417

tcgactatga?cgagacccgt?gaaaacttcg?cgcttggtta?caagttcgac?atcgtccttc?60

gtggccgcaa?cgccacccca?tttgagtaaa?gggttttgca?atg?att?gat?aca?ggg 115

Met?Ile?Asp?Thr?Gly

1 5

aag?aac?ggc?gag?ttc?cgc?tac?gag?cag?tcg?aat?atc?atc?gat?cag?aac 163

Lys?Asn?Gly?Glu?Phe?Arg?Tyr?Glu?Gln?Ser?Asn?Ile?Ile?Asp?Gln?Asn

10 15 20

gaa?gcc?gag?ttc?ggc?atc?act?cct?tca?cag?acc?gtg?ggc?cct?tac?gtc 211

Glu?Ala?Glu?Phe?Gly?Ile?Thr?Pro?Ser?Gln?Thr?Val?Gly?Pro?Tyr?Val

25 30 35

cac?atc?ggt?ttg?acc?ctt?gaa?ggt?gcg?gag?cat?ctc?gtg?gag?cca?ggt 259

His?Ile?Gly?Leu?Thr?Leu?Glu?Gly?Ala?Glu?His?Leu?Val?Glu?Pro?Gly

40 45 50

tcg?gaa?ggc?gcg?gtg?tcc?ttt?act?gtt?tcc?gca?act?gat?ggc?aac?ggc 307

Ser?Glu?Gly?Ala?Val?Ser?Phe?Thr?Val?Ser?Ala?Thr?Asp?Gly?Asn?Gly

55 60 65

gac?ccc?atc?gcg?gat?gcc?atg?ttt?gaa?ctg?tgg?cag?gcc?gat?cca?gag 355

Asp?Pro?Ile?Ala?Asp?Ala?Met?Phe?Glu?Leu?Trp?Gln?Ala?Asp?Pro?Glu

70 75 80 85

ggc?atc?cac?aac?tct?gat?ttg?gat?cca?aac?cgc?aca?gca?cca?gca?acc 403

Gly?Ile?His?Asn?Ser?Asp?Leu?Asp?Pro?Asn?Arg?Thr?Ala?Pro?Ala?Thr

90 95 100

gca?gat?ggc?ttc?cgc?ggg?ctt?ggt?cgc?gcg?atg?gca?aac?gcg?cag?ggt 451

Ala?Asp?Gly?Phe?Arg?Gly?Leu?Gly?Arg?Ala?Met?Ala?Asn?Ala?Gln?Gly

105 110 115

gag?gca?acg?ttc?acc?act?ttg?gtt?ccg?gga?gca?ttc?gca?gat?gag?gca 499

Glu?Ala?Thr?Phe?Thr?Thr?Leu?Val?Pro?Gly?Ala?Phe?Ala?Asp?Glu?Ala

120 125 130

cca?cac?ttc?aag?gtt?ggt?gtg?ttc?gcc?cgt?ggc?atg?ctg?gag?cgt?ctg 547

Pro?His?Phe?Lys?Val?Gly?Val?Phe?Ala?Arg?Gly?Met?Leu?Glu?Arg?Leu

135 140 145

tac?act?cgc?gca?tac?ctg?cca?gac?gcc?gat?ttg?agc?acc?gac?cca?gtt 595

Tyr?Thr?Arg?Ala?Tyr?Leu?Pro?Asp?Ala?Asp?Leu?Ser?Thr?Asp?Pro?Val

150 155 160 165

ttg?gct?gtg?gtc?cca?gct?gat?cga?cgt?gac?ctc?ctg?gtg?gct?caa?aag 643

Leu?Ala?Val?Val?Pro?Ala?Asp?Arg?Arg?Asp?Leu?Leu?Val?Ala?Gln?Lys

170 175 180

acc?gat?gat?gga?ttc?cgc?ttc?gac?atc?act?gtc?cag?gct?gaa?gac?aat 691

Thr?Asp?Asp?Gly?Phe?Arg?Phe?Asp?Ile?Thr?Val?Gln?Ala?Glu?Asp?Asn

185 190 195

gaa?acc?cca?ttt?ttt?gga?ctc?taaattgacc?cgatctttat?act 735

Glu?Thr?Pro?Phe?Phe?Gly?Leu

200

<210>418

<211>204

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>418

Met?Ile?Asp?Thr?Gly?Lys?Asn?Gly?Glu?Phe?Arg?Tyr?Glu?Gln?Ser?Asn

1 5 10 15

Ile?Ile?Asp?Gln?Asn?Glu?Ala?Glu?Phe?Gly?Ile?Thr?Pro?Ser?Gln?Thr

20 25 30

Val?Gly?Pro?Tyr?Val?His?Ile?Gly?Leu?Thr?Leu?Glu?Gly?Ala?Glu?His

35 40 45

Leu?Val?Glu?Pro?Gly?Ser?Glu?Gly?Ala?Val?Ser?Phe?Thr?Val?Ser?Ala

50 55 60

Thr?Asp?Gly?Asn?Gly?Asp?Pro?Ile?Ala?Asp?Ala?Met?Phe?Glu?Leu?Trp

65 70 75 80

Gln?Ala?Asp?Pro?Glu?Gly?Ile?His?Asn?Ser?Asp?Leu?Asp?Pro?Asn?Arg

85 90 95

Thr?Ala?Pro?Ala?Thr?Ala?Asp?Gly?Phe?Arg?Gly?Leu?Gly?Arg?Ala?Met

100 105 110

Ala?Asn?Ala?Gln?Gly?Glu?Ala?Thr?Phe?Thr?Thr?Leu?Val?Pro?Gly?Ala

115 120 125

Phe?Ala?Asp?Glu?Ala?Pro?His?Phe?Lys?Val?Gly?Val?Phe?Ala?Arg?Gly

130 135 140

Met?Leu?Glu?Arg?Leu?Tyr?Thr?Arg?Ala?Tyr?Leu?Pro?Asp?Ala?Asp?Leu

145 150 155 160

Ser?Thr?Asp?Pro?Val?Leu?Ala?Val?Val?Pro?Ala?Asp?Arg?Arg?Asp?Leu

165 170 175

Leu?Val?Ala?Gln?Lys?Thr?Asp?Asp?Gly?Phe?Arg?Phe?Asp?Ile?Thr?Val

180 185 190

Gln?Ala?Glu?Asp?Asn?Glu?Thr?Pro?Phe?Phe?Gly?Leu

195 200

<210>419

<211>1584

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1561)

<223>RXN01653

<400>419

ttcattcagg?gtgaatgctc?tccttgtttc?agatgttcaa?cgctccataa?agtagaccgc?60

aatctagaca?aagatgtcta?ttttaattaa?ggagcagaac?atg?gcc?acg?gcc?gag 115

Met?Ala?Thr?Ala?Glu

1 5

aac?aca?aca?cag?gag?aat?cgg?aaa?atc?ctg?ttc?aac?gca?ttt?gat?atg 163

Asn?Thr?Thr?Gln?Glu?Asn?Arg?Lys?Ile?Leu?Phe?Asn?Ala?Phe?Asp?Met

10 15 20

aac?tgc?gtt?gcg?cat?cag?tcc?cca?gga?ctg?tgg?aca?cac?ccg?aag?gat 211

Asn?Cys?Val?Ala?His?Gln?Ser?Pro?Gly?Leu?Trp?Thr?His?Pro?Lys?Asp

25 30 35

aag?gcg?cga?gac?tac?aac?act?ctt?gat?tac?tgg?gtg?cac?ctt?gcc?aag 259

Lys?Ala?Arg?Asp?Tyr?Asn?Thr?Leu?Asp?Tyr?Trp?Val?His?Leu?Ala?Lys

40 45 50

act?ttg?gag?aag?ggc?ctt?ttc?gac?ggc?ctt?ttc?atc?gca?gat?gtg?ctt 307

Thr?Leu?Glu?Lys?Gly?Leu?Phe?Asp?Gly?Leu?Phe?Ile?Ala?Asp?Val?Leu

55 60 65

gga?act?tac?gat?gtt?tat?ggt?tct?agt?aat?gaa?gcg?gcg?ttg?agc?agt 355

Gly?Thr?Tyr?Asp?Val?Tyr?Gly?Ser?Ser?Asn?Glu?Ala?Ala?Leu?Ser?Ser

70 75 80 85

ggt?gcg?cag?gtg?cct?gtc?aat?gat?ccg?atc?ctt?ctt?gtt?tct?gcg?atg 403

Gly?Ala?Gln?Val?Pro?Val?Asn?Asp?Pro?Ile?Leu?Leu?Val?Ser?Ala?Met

90 95 100

gcc?tat?gcc?aca?aag?aac?ctc?ggg?ttt?ggc?att?act?gca?ggt?act?gcc 451

Ala?Tyr?Ala?Thr?Lys?Asn?Leu?Gly?Phe?Gly?Ile?Thr?Ala?Gly?Thr?Ala

105 110 115

tat?gag?cac?ccg?tat?cct?ttt?gcg?cgg?cgt?ctg?gcc?aca?ctt?gat?cac 499

Tyr?Glu?His?Pro?Tyr?Pro?Phe?Ala?Arg?Arg?Leu?Ala?Thr?Leu?Asp?His

120 125 130

ctg?act?aat?ggg?cgt?gtg?ggg?tgg?aat?gtg?gtt?act?ggc?tat?ctt?ccc 547

Leu?Thr?Asn?Gly?Arg?Val?Gly?Trp?Asn?Val?Val?Thr?Gly?Tyr?Leu?Pro

135 140 145

tct?gct?gct?caa?aac?atg?ggt?gac?acc?gat?cag?ctg?cca?cat?gat?gag 595

Ser?Ala?Ala?Gln?Asn?Met?Gly?Asp?Thr?Asp?Gln?Leu?Pro?His?Asp?Glu

150 155 160 165

cgc?tat?gac?aaa?gca?gat?gaa?tac?ctg?gaa?gtg?atc?tac?aag?ctt?ctc 643

Arg?Tyr?Asp?Lys?Ala?Asp?Glu?Tyr?Leu?Glu?Val?Ile?Tyr?Lys?Leu?Leu

170 175 180

gag?ggc?tcc?tgg?gaa?gac?gat?gct?gtt?caa?aac?aat?acg?gag?acg?agt 691

Glu?Gly?Ser?Trp?Glu?Asp?Asp?Ala?Val?Gln?Asn?Asn?Thr?Glu?Thr?Ser

185 190 195

gtc?ttt?acg?gac?tcc?tcc?aaa?gtg?cac?gcc?att?aat?cat?cat?ggc?aag 739

Val?Phe?Thr?Asp?Ser?Ser?Lys?Val?His?Ala?Ile?Asn?His?His?Gly?Lys

200 205 210

tac?ttt?gat?gtg?ccg?ggc?att?gcc?atc?act?gag?ccg?agt?gtg?cag?cgt 787

Tyr?Phe?Asp?Val?Pro?Gly?Ile?Ala?Ile?Thr?Glu?Pro?Ser?Val?Gln?Arg

215 220 225

acg?ccg?gtg?atc?tac?cag?gcg?ggt?gca?tcg?ccg?cgc?gga?ttg?aaa?ttc 835

Thr?Pro?Val?Ile?Tyr?Gln?Ala?Gly?Ala?Ser?Pro?Arg?Gly?Leu?Lys?Phe

230 235 240 245

gct?ggt?gag?aat?gca?gaa?gca?gtg?ttt?atc?aat?tcc?agc?acc?gtg?gag 883

Ala?Gly?Glu?Asn?Ala?Glu?Ala?Val?Phe?Ile?Asn?Ser?Ser?Thr?Val?Glu

250 255 260

gca?atc?acc?aag?act?gtc?gca?aaa?att?cgc?gct?gct?gcg?gtc?gct?gcg 931

Ala?Ile?Thr?Lys?Thr?Val?Ala?Lys?Ile?Arg?Ala?Ala?Ala?Val?Ala?Ala

265 270 275

gga?cgt?gat?cca?cat?gcg?gtg?aag?atc?ttt?gcg?atg?caa?acc?atc?atc 979

Gly?Arg?Asp?Pro?His?Ala?Val?Lys?Ile?Phe?Ala?Met?Gln?Thr?Ile?Ile

280 285 290

act?ggt?gaa?aca?gaa?gca?gat?gcg?cag?gca?aag?ctg?gag?gaa?tac?agt 1027

Thr?Gly?Glu?Thr?Glu?Ala?Asp?Ala?Gln?Ala?Lys?Leu?Glu?Glu?Tyr?Ser

295 300 305

cgc?tat?atc?gat?cct?gtc?ggt?ggt?ctg?acc?ttg?atg?tct?gga?tgg?acc 1075

Arg?Tyr?Ile?Asp?Pro?Val?Gly?Gly?Leu?Thr?Leu?Met?Ser?Gly?Trp?Thr

310 315 320 325

ggc?gcg?gat?ctg?tcg?cag?tat?gac?ctg?gat?gaa?ccg?atc?acc?aat?att 1123

Gly?Ala?Asp?Leu?Ser?Gln?Tyr?Asp?Leu?Asp?Glu?Pro?Ile?Thr?Asn?Ile

330 335 340

gag?tca?aac?gct?att?cag?tcc?act?gca?gcc?acc?att?agc?aac?ggc?acc 1171

Glu?Ser?Asn?Ala?Ile?Gln?Ser?Thr?Ala?Ala?Thr?Ile?Ser?Asn?Gly?Thr

345 350 355

ggt?gaa?ggt?gcg?tgg?acg?gta?cgc?aaa?ctg?ggt?gag?gca?acc?ggc?atc 1219

Gly?Glu?Gly?Ala?Trp?Thr?Val?Arg?Lys?Leu?Gly?Glu?Ala?Thr?Gly?Ile

360 365 370

ggc?ggc?ttc?gga?cca?gtg?ctt?gtg?gga?tct?ggc?gct?aac?gtt?gcc?gcg 1267

Gly?Gly?Phe?Gly?Pro?Val?Leu?Val?Gly?Ser?Gly?Ala?Asn?Val?Ala?Ala

375 380 385

gaa?ctt?gca?cgc?atc?cag?gat?ctc?agc?gat?gtt?gat?ggt?ttc?aac?ctt 1315

Glu?Leu?Ala?Arg?Ile?Gln?Asp?Leu?Ser?Asp?Val?Asp?Gly?Phe?Asn?Leu

390 395 400 405

gct?tat?gcc?atc?acc?cca?gga?act?ttt?gaa?gat?gtc?gtg?gac?ttt?gtg 1363

Ala?Tyr?Ala?Ile?Thr?Pro?Gly?Thr?Phe?Glu?Asp?Val?Val?Asp?Phe?Val

410 415 420

gtg?cct?gag?ctg?caa?aaa?ctt?agc?cgc?tac?aag?acg?gaa?tac?gcg?ccg 1411

Val?Pro?Glu?Leu?Gln?Lys?Leu?Ser?Arg?Tyr?Lys?Thr?Glu?Tyr?Ala?Pro

425 430 435

ggt?tcc?ttg?cgc?aac?aaa?ttg?ctc?ggt?aaa?ggt?gat?cgc?ctg?gac?gat 1459

Gly?Ser?Leu?Arg?Asn?Lys?Leu?Leu?Gly?Lys?Gly?Asp?Arg?Leu?Asp?Asp

440 445 450

acc?cac?cgc?ggc?gca?agc?tac?cgc?cta?ggc?gct?cgg?aac?tcc?acc?gcc 1507

Thr?His?Arg?Gly?Ala?Ser?Tyr?Arg?Leu?Gly?Ala?Arg?Asn?Ser?Thr?Ala

455 460 465

act?att?gat?ctc?agt?tcc?ata?tcc?gcc?caa?cta?gtt?tcc?cag?gga?gcc 1555

Thr?Ile?Asp?Leu?Ser?Ser?Ile?Ser?Ala?Gln?Leu?Val?Ser?Gln?Gly?Ala

470 475 480 485

cac?tca?tgatctcacc?gcaaacaatc?atc 1584

His?Ser

<210>420

<211>487

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>420

Met?Ala?Thr?Ala?Glu?Asn?Thr?Thr?Gln?Glu?Asn?Arg?Lys?Ile?Leu?Phe

1 5 10 15

Asn?Ala?Phe?Asp?Met?Asn?Cys?Val?Ala?His?Gln?Ser?Pro?Gly?Leu?Trp

20 25 30

Thr?His?Pro?Lys?Asp?Lys?Ala?Arg?Asp?Tyr?Asn?Thr?Leu?Asp?Tyr?Trp

35 40 45

Val?His?Leu?Ala?Lys?Thr?Leu?Glu?Lys?Gly?Leu?Phe?Asp?Gly?Leu?Phe

50 55 60

Ile?Ala?Asp?Val?Leu?Gly?Thr?Tyr?Asp?Val?Tyr?Gly?Ser?Ser?Asn?Glu

65 70 75 80

Ala?Ala?Leu?Ser?Ser?Gly?Ala?Gln?Val?Pro?Val?Asn?Asp?Pro?Ile?Leu

85 90 95

Leu?Val?Ser?Ala?Met?Ala?Tyr?Ala?Thr?Lys?Asn?Leu?Gly?Phe?Gly?Ile

100 105 110

Thr?Ala?Gly?Thr?Ala?Tyr?Glu?His?Pro?Tyr?Pro?Phe?Ala?Arg?Arg?Leu

115 120 125

Ala?Thr?Leu?Asp?His?Leu?Thr?Asn?Gly?Arg?Val?Gly?Trp?Asn?Val?Val

130 135 140

Thr?Gly?Tyr?Leu?Pro?Ser?Ala?Ala?Gln?Asn?Met?Gly?Asp?Thr?Asp?Gln

145 150 155 160

Leu?Pro?His?Asp?Glu?Arg?Tyr?Asp?Lys?Ala?Asp?Glu?Tyr?Leu?Glu?Val

165 170 175

Ile?Tyr?Lys?Leu?Leu?Glu?Gly?Ser?Trp?Glu?Asp?Asp?Ala?Val?Gln?Asn

180 185 190

Asn?Thr?Glu?Thr?Ser?Val?Phe?Thr?Asp?Ser?Ser?Lys?Val?His?Ala?Ile

195 200 205

Asn?His?His?Gly?Lys?Tyr?Phe?Asp?Val?Pro?Gly?Ile?Ala?Ile?Thr?Glu

210 215 220

Pro?Ser?Val?Gln?Arg?Thr?Pro?Val?Ile?Tyr?Gln?Ala?Gly?Ala?Ser?Pro

225 230 235 240

Arg?Gly?Leu?Lys?Phe?Ala?Gly?Glu?Asn?Ala?Glu?Ala?Val?Phe?Ile?Asn

245 250 255

Ser?Ser?Thr?Val?Glu?Ala?Ile?Thr?Lys?Thr?Val?Ala?Lys?Ile?Arg?Ala

260 265 270

Ala?Ala?Val?Ala?Ala?Gly?Arg?Asp?Pro?His?Ala?Val?Lys?Ile?Phe?Ala

275 280 285

Met?Gln?Thr?Ile?Ile?Thr?Gly?Glu?Thr?Glu?Ala?Asp?Ala?Gln?Ala?Lys

290 295 300

Leu?Glu?Glu?Tyr?Ser?Arg?Tyr?Ile?Asp?Pro?Val?Gly?Gly?Leu?Thr?Leu

305 310 315 320

Met?Ser?Gly?Trp?Thr?Gly?Ala?Asp?Leu?Ser?Gln?Tyr?Asp?Leu?Asp?Glu

325 330 335

Pro?Ile?Thr?Asn?Ile?Glu?Ser?Asn?Ala?Ile?Gln?Ser?Thr?Ala?Ala?Thr

340 345 350

Ile?Ser?Asn?Gly?Thr?Gly?Glu?Gly?Ala?Trp?Thr?Val?Arg?Lys?Leu?Gly

355 360 365

Glu?Ala?Thr?Gly?Ile?Gly?Gly?Phe?Gly?Pro?Val?Leu?Val?Gly?Ser?Gly

370 375 380

Ala?Asn?Val?Ala?Ala?Glu?Leu?Ala?Arg?Ile?Gln?Asp?Leu?Ser?Asp?Val

385 390 395 400

Asp?Gly?Phe?Asn?Leu?Ala?Tyr?Ala?Ile?Thr?Pro?Gly?Thr?Phe?Glu?Asp

405 410 415

Val?Val?Asp?Phe?Val?Val?Pro?Glu?Leu?Gln?Lys?Leu?Ser?Arg?Tyr?Lys

420 425 430

Thr?Glu?Tyr?Ala?Pro?Gly?Ser?Leu?Arg?Asn?Lys?Leu?Leu?Gly?Lys?Gly

435 440 445

Asp?Arg?Leu?Asp?Asp?Thr?His?Arg?Gly?Ala?Ser?Tyr?Arg?Leu?Gly?Ala

450 455 460

Arg?Asn?Ser?Thr?Ala?Thr?Ile?Asp?Leu?Ser?Ser?Ile?Ser?Ala?Gln?Leu

465 470 475 480

Val?Ser?Gln?Gly?Ala?His?Ser

485

<210>421

<211>702

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(679)

<223>RXN02053

<400>421

aaccagccag?aaactatctc?caaaagctaa?taaaaccctt?gcactgacaa?ataaggcgac?60

ctaccatgac?tctgtttcca?acacataaaa?aggataaaaa?atg?tca?ctt?tca?gtc 115

Met?Ser?Leu?Ser?Val

1 5

gtc?gag?gcg?att?acc?aac?cgc?cgc?gcc?acc?cgc?aaa?tac?acc?gat?gaa 163

Val?Glu?Ala?Ile?Thr?Asn?Arg?Arg?Ala?Thr?Arg?Lys?Tyr?Thr?Asp?Glu

10 15 20

gct?cct?acc?cct?gag?ctg?atc?gac?aaa?atc?gtt?gac?ctt?gcc?ctg?gag 211

Ala?Pro?Thr?Pro?Glu?Leu?Ile?Asp?Lys?Ile?Val?Asp?Leu?Ala?Leu?Glu

25 30 35

gca?ccc?agt?gcg?ttc?aat?gcg?cag?caa?cgt?gaa?att?gtt?gtg?att?act 259

Ala?Pro?Ser?Ala?Phe?Asn?Ala?Gln?Gln?Arg?Glu?Ile?Val?Val?Ile?Thr

40 45 50

gat?ccc?gca?cag?aag?cag?aag?ctt?tac?gag?gcc?tcc?cat?cag?aaa?caa 307

Asp?Pro?Ala?Gln?Lys?Gln?Lys?Leu?Tyr?Glu?Ala?Ser?His?Gln?Lys?Gln

55 60 65

ttc?ctc?acc?gca?oct?gta?act?ttc?att?gcg?gtt?gcc?cgc?gtg?gaa?aac 355

Phe?Leu?Thr?Ala?Pro?Val?Thr?Phe?Ile?Ala?Val?Ala?Arg?Val?Glu?Asn

70 75 80 85

gag?cct?gag?gat?ttg?gaa?gag?att?ctt?ggt?acg?gaa?agg?gct?gaa?cgt 403

Glu?Pro?Glu?Asp?Leu?Glu?Glu?Ile?Leu?Gly?Thr?Glu?Arg?Ala?Glu?Arg

90 95 100

gtc?gcg?gga?ttc?atc?aac?ggt?cgc?agc?att?cag?cag?gca?cgc?gaa?gca 451

Val?Ala?Gly?Phe?Ile?Asn?Gly?Arg?Ser?Ile?Gln?Gln?Ala?Arg?Glu?Ala

105 110 115

acg?ttg?agg?gat?gcc?agc?ctc?gcg?gcg?gct?ttt?cta?att?ctg?gct?gcc 499

Thr?Leu?Arg?Asp?Ala?Ser?Leu?Ala?Ala?Ala?Phe?Leu?Ile?Leu?Ala?Ala

120 125 130

cag?gcg?gag?ggt?ttg?agt?acc?agc?ccg?act?act?ggt?tgg?gat?gag?gaa 547

Gln?Ala?Glu?Gly?Leu?Ser?Thr?Ser?Pro?Thr?Thr?Gly?Trp?Asp?Glu?Glu

135 140 145

aaa?gtg?aag?gaa?gca?atc?ggt?ctc?ggc?ggg?cgt?gag?gat?cgt?gca?atc 595

Lys?Val?Lys?Glu?Ala?Ile?Gly?Leu?Gly?Gly?Arg?Glu?Asp?Arg?Ala?Ile

150 155 160 165

gcc?ctt?gtt?att?gct?acc?gga?ttc?cct?aat?gaa?cag?ccg?gag?cac?cct 643

Ala?Leu?Val?Ile?Ala?Thr?Gly?Phe?Pro?Asn?Glu?Gln?Pro?Glu?His?Pro

170 175 180

ggt?cgt?ttg?cag?aat?agg?cgc?atc?gac?aac?agc?tac?taactctgcc 689

Gly?Arg?Leu?Gln?Asn?Arg?Arg?Ile?Asp?Asn?Ser?Tyr

185 190

agctcgcccg?gac 702

<210>422

<211>193

<2l2>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>422

Met?Ser?Leu?Ser?Val?Val?Glu?Ala?Ile?Thr?Asn?Arg?Arg?Ala?Thr?Arg

1 5 10 15

Lys?Tyr?Thr?Asp?Glu?Ala?Pro?Thr?Pro?Glu?Leu?Ile?Asp?Lys?Ile?Val

20 25 30

Asp?Leu?Ala?Leu?Glu?Ala?Pro?Ser?Ala?Phe?Asn?Ala?Gln?Gln?Arg?Glu

35 40 45

Ile?Val?Val?Ile?Thr?Asp?Pro?Ala?Gln?Lys?Gln?Lys?Leu?Tyr?Glu?Ala

50 55 60

Ser?His?Gln?Lys?Gln?Phe?Leu?Thr?Ala?Pro?Val?Thr?Phe?Ile?Ala?Val

65 70 75 80

Ala?Arg?Val?Glu?Asn?Glu?Pro?Glu?Asp?Leu?Glu?Glu?Ile?Leu?Gly?Thr

85 90 95

Glu?Arg?Ala?Glu?Arg?Val?Ala?Gly?Phe?Ile?Asn?Gly?Arg?Ser?Ile?Gln

100 105 110

Gln?Ala?Arg?Glu?Ala?Thr?Leu?Arg?Asp?Ala?Ser?Leu?Ala?Ala?Ala?Phe

115 120 125

Leu?Ile?Leu?Ala?Ala?Gln?Ala?Glu?Gly?Leu?Ser?Thr?Ser?Pro?Thr?Thr

130 135 140

Gly?Trp?Asp?Glu?Glu?Lys?Val?Lys?Glu?Ala?Ile?Gly?Leu?Gly?Gly?Arg

145 150 155 160

Glu?Asp?Arg?Ala?Ile?Ala?Leu?Val?Ile?Ala?Thr?Gly?Phe?Pro?Asn?Glu

165 170 175

Gln?Pro?Glu?His?Pro?Gly?Arg?Leu?Gln?Asn?Arg?Arg?Ile?Asp?Asn?Ser

180 185 190

Tyr

<210>423

<211>1191

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1168)

<223>RXN00177

<400>423

ctattccaca?gcagtggacg?ctgaacaact?tcaaacacag?attaagcagc?tatcggatct?60

acttcacctc?aactcagttg?tcggagcata?ggagctaaaa?atg?tct?tta?cag?ttc 115

Met?Ser?Leu?Gln?Phe

1 5

gat?cat?gaa?acc?ctc?ggt?caa?cga?gtt?ctg?ttc?ggt?tca?ggt?gag?gcg 163

Asp?His?Glu?Thr?Leu?Gly?Gln?Arg?Val?Leu?Phe?Gly?Ser?Gly?Glu?Ala

10 15 20

gcg?caa?aat?ctc?gcc?gct?gaa?att?agc?cga?ctc?gat?gcc?aaa?aac?gtc 211

Ala?Gln?Asn?Leu?Ala?Ala?Glu?Ile?Ser?Arg?Leu?Asp?Ala?Lys?Asn?Val

25 30 35

atg?gtg?gtt?gcc?ggt?gat?ttc?gag?ctt?ccc?atg?gca?cgg?caa?gta?gca 259

Met?Val?Val?Ala?Gly?Asp?Phe?Glu?Leu?Pro?Met?Ala?Arg?Gln?Val?Ala

40 45 50

gca?gat?att?gat?gtc?aag?gtg?tgg?cat?tca?aat?gtc?gtg?atg?cat?gtg 307

Ala?Asp?Ile?Asp?Val?Lys?Val?Trp?His?Ser?Asn?Val?Val?Met?His?Val

55 60 65

ccc?atc?gaa?aca?gca?gaa?gaa?gca?cgc?agt?gtt?gcg?aaa?gaa?aac?gac 355

Pro?Ile?Glu?Thr?Ala?Glu?Glu?Ala?Arg?Ser?Val?Ala?Lys?Glu?Asn?Asp

70 75 80 85

att?gat?gtt?gtg?gtg?tgt?gtg?ggc?ggt?gga?tcc?aca?aca?ggt?cta?gct 403

Ile?Asp?Val?Val?Val?Cys?Val?Gly?Gly?Gly?Ser?Thr?Thr?Gly?Leu?Ala

90 95 100

aaa?gcg?att?gcc?atg?acc?acc?gca?ttg?ccg?atc?att?gcg?gta?ccc?act 451

Lys?Ala?Ile?Ala?Met?Thr?Thr?Ala?Leu?Pro?Ile?Ile?Ala?Val?Pro?Thr

105 110 115

act?tat?gca?ggt?tct?gaa?gca?aca?aat?gtg?tgg?gga?ttg?acc?gaa?gcc 499

Thr?Tyr?Ala?Gly?Ser?Glu?Ala?Thr?Asn?Val?Trp?Gly?Leu?Thr?Glu?Ala

120 125 130

gcg?cgc?aaa?aca?act?ggt?gtt?gat?aac?aaa?gtg?ctg?cca?gtg?aca?gtt 547

Ala?Arg?Lys?Thr?Thr?Gly?Val?Asp?Asn?Lys?Val?Leu?Pro?Val?Thr?Val

135 140 145

atc?tac?gat?tca?gcg?tta?acc?atg?tct?ttg?ccg?gta?gaa?atg?tcg?gtt 595

Ile?Tyr?Asp?Ser?Ala?Leu?Thr?Met?Ser?Leu?Pro?Val?Glu?Met?Ser?Val

150 155 160 165

gct?tct?ggt?ctc?aat?ggt?ttg?gct?cac?tgc?att?gat?tct?ttg?tgg?gga 643

Ala?Ser?Gly?Leu?Asn?Gly?Leu?Ala?His?Cys?Ile?Asp?Ser?Leu?Trp?Gly

170 175 180

ccg?aag?gcg?gat?ccc?atc?aat?gcg?gct?atg?gct?gct?gag?gga?att?cga 691

Pro?Lys?Ala?Asp?Pro?Ile?Asn?Ala?Ala?Met?Ala?Ala?Glu?Gly?Ile?Arg

185 190 195

gca?ctt?tct?gct?ggc?ctt?ccc?aag?att?gtg?gca?gat?gct?cag?gac?gta 739

Ala?Leu?Ser?Ala?Gly?Leu?Pro?Lys?Ile?Val?Ala?Asp?Ala?Gln?Asp?Val

200 205 210

gat?ggt?cgc?gat?gaa?gcg?ctc?tac?ggt?gcc?tac?ctg?gct?gcg?gtg?tct 787

Asp?Gly?Arg?Asp?Glu?Ala?Leu?Tyr?Gly?Ala?Tyr?Leu?Ala?Ala?Val?Ser

215 220 225

ttt?gcc?tct?gct?ggc?tct?ggt?ctc?cac?cac?aag?atc?tgc?cac?gtg?ttg 835

Phe?Ala?Ser?Ala?Gly?Ser?Gly?Leu?His?His?Lys?Ile?Cys?His?Val?Leu

230 235 240 245

ggt?gga?act?ttt?aac?ctt?cca?cac?gcg?caa?acc?cat?gca?aca?gta?ctg 883

Gly?Gly?Thr?Phe?Asn?Leu?Pro?His?Ala?Gln?Thr?His?Ala?Thr?Val?Leu

250 255 260

cct?tat?gtt?ctt?gcc?ttc?aac?gcg?cca?tat?gcg?cca?cag?gca?gaa?caa 931

Pro?Tyr?Val?Leu?Ala?Phe?Asn?Ala?Pro?Tyr?Ala?Pro?Gln?Ala?Glu?Gln

265 270 275

cgc?gca?gcg?gca?gct?ttc?ggt?tct?gcg?aca?gca?ctt?gaa?gga?ttg?caa 979

Arg?Ala?Ala?Ala?Ala?Phe?Gly?Ser?Ala?Thr?Ala?Leu?Glu?Gly?Leu?Gln

280 285 290

cag?ctg?cgt?gcc?caa?gtg?gga?gca?cca?cag?cga?cta?tcc?gat?tac?gga 1027

Gln?Leu?Arg?Ala?Gln?Val?Gly?Ala?Pro?Gln?Arg?Leu?Ser?Asp?Tyr?Gly

295 300 305

ttc?acc?gca?gca?gga?atc?cca?gag?gca?gtg?gaa?atc?atc?ttg?gag?aaa 1075

Phe?Thr?Ala?Ala?Gly?Ile?Pro?Glu?Ala?Val?Glu?Ile?Ile?Leu?Glu?Lys

310 315 320 325

gta?ccg?gcg?aat?aat?cca?cgg?acg?gtc?aca?gaa?gaa?aac?ctc?act?gcg 1l23

Val?Pro?Ala?Asn?Asn?Pro?Arg?Thr?Val?Thr?Glu?Glu?Asn?Leu?Thr?Ala

330 335 340

ctg?ctt?acc?aca?gcg?ctc?aac?ggc?gac?gat?cca?gca?act?ttg?aat 1168

Leu?Leu?Thr?Thr?Ala?Leu?Asn?Gly?Asp?Asp?Pro?Ala?Thr?Leu?Asn

345 350 355

taaggagacc?aacatgacta?ttt 1191

<210>424

<211>356

<212>PRT

＜2l3〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>424

Met?Ser?Leu?Gln?Phe?Asp?His?Glu?Thr?Leu?Gly?Gln?Arg?Val?Leu?Phe

1 5 10 15

Gly?Ser?Gly?Glu?Ala?Ala?Gln?Asn?Leu?Ala?Ala?Glu?Ile?Ser?Arg?Leu

20 25 30

Asp?Ala?Lys?Asn?Val?Met?Val?Val?Ala?Gly?Asp?Phe?Glu?Leu?Pro?Met

35 40 45

Ala?Arg?Gln?Val?Ala?Ala?Asp?Ile?Asp?Val?Lys?Val?Trp?His?Ser?Asn

50 55 60

Val?Val?Met?His?Val?Pro?Ile?Glu?Thr?Ala?Glu?Glu?Ala?Arg?Ser?Val

65 70 75 80

Ala?Lys?Glu?Asn?Asp?Ile?Asp?Val?Val?Val?Cys?Val?Gly?Gly?Gly?Ser

85 90 95

Thr?Thr?Gly?Leu?Ala?Lys?Ala?Ile?Ala?Met?Thr?Thr?Ala?Leu?Pro?Ile

100 105 110

Ile?Ala?Val?Pro?Thr?Thr?Tyr?Ala?Gly?Ser?Glu?Ala?Thr?Asn?Val?Trp

115 120 125

Gly?Leu?Thr?Glu?Ala?Ala?Arg?Lys?Thr?Thr?Gly?Val?Asp?Asn?Lys?Val

130 135 140

Leu?Pro?Val?Thr?Val?Ile?Tyr?Asp?Ser?Ala?Leu?Thr?Met?Ser?Leu?Pro

145 150 155 160

Val?Glu?Met?Ser?Val?Ala?Ser?Gly?Leu?Asn?Gly?Leu?Ala?His?Cys?Ile

165 170 175

Asp?Ser?Leu?Trp?Gly?Pro?Lys?Ala?Asp?Pro?Ile?Asn?Ala?Ala?Met?Ala

180 185 190

Ala?Glu?Gly?Ile?Arg?Ala?Leu?Ser?Ala?Gly?Leu?Pro?Lys?Ile?Val?Ala

195 200 205

Asp?Ala?Gln?Asp?Val?Asp?Gly?Arg?Asp?Glu?Ala?Leu?Tyr?Gly?Ala?Tyr

210 215 220

Leu?Ala?Ala?Val?Ser?Phe?Ala?Ser?Ala?Gly?Ser?Gly?Leu?His?His?Lys

225 230 235 240

Ile?Cys?His?Val?Leu?Gly?Gly?Thr?Phe?Asn?Leu?Pro?His?Ala?Gln?Thr

245 250 255

His?Ala?Thr?Val?Leu?Pro?Tyr?Val?Leu?Ala?Phe?Asn?Ala?Pro?Tyr?Ala

260 265 270

Pro?Gln?Ala?Glu?Gln?Arg?Ala?Ala?Ala?Ala?Phe?Gly?Ser?Ala?Thr?Ala

275 280 285

Leu?Glu?Gly?Leu?Gln?Gln?Leu?Arg?Ala?Gln?Val?Gly?Ala?Pro?Gln?Arg

290 295 300

Leu?Ser?Asp?Tyr?Gly?Phe?Thr?Ala?Ala?Gly?Ile?Pro?Glu?Ala?Val?Glu

305 310 315 320

Ile?Ile?Leu?Glu?Lys?Val?Pro?Ala?Asn?Asn?Pro?Arg?Thr?Val?Thr?Glu

325 330 335

Glu?Asn?Leu?Thr?Ala?Leu?Leu?Thr?Thr?Ala?Leu?Asn?Gly?Asp?Asp?Pro

340 345 350

Ala?Thr?Leu?Asn

355

<210>425

<211>960

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(937)

<223>RXC00963

<400>425

ctggctctga?cggcgtcgac?ttgttctgct?tctctgatac?accaattttc?gaggccctta?60

acctcgcacg?tacttttact?ccggaaggaa?tctagaactt?atg?cgt?ctt?gca?aca 115

Met?Arg?Leu?Ala?Thr

l 5

atc?cgc?acc?aac?ggc?acc?acc?att?gct?gct?cgt?gtt?gaa?tct?gaa?aac 163

Ile?Arg?Thr?Asn?Gly?Thr?Thr?Ile?Ala?Ala?Arg?Val?Glu?Ser?Glu?Asn

10 15 20

acc?gct?acc?acc?atc?gag?ggc?ttt?gcc?aac?gtc?ggt?gaa?tta?ctc?cag 211

Thr?Ala?Thr?Thr?Ile?Glu?Gly?Phe?Ala?Asn?Val?Gly?Glu?Leu?Leu?Gln

25 30 35

gaa?tcc?aac?tgg?cgc?gag?ctg?gca?gaa?aac?gct?gct?ggt?gag?gct?gtg 259

Glu?Ser?Asn?Trp?Arg?Glu?Leu?Ala?Glu?Asn?Ala?Ala?Gly?Glu?Ala?Val

40 45 50

acc?ttt?gaa?aac?aag?gag?cta?gat?gca?gta?gtt?cca?gca?cct?aag?aag 307

Thr?Phe?Glu?Asn?Lys?Glu?Leu?Asp?Ala?Val?Val?Pro?Ala?Pro?Lys?Lys

55 60 65

att?gtg?tgc?gtc?ggc?ctt?aac?tac?gcc?aac?cac?att?aaa?gaa?atg?ggc 355

Ile?Val?Cys?Val?Gly?Leu?Asn?Tyr?Ala?Asn?His?Ile?Lys?Glu?Met?Gly

70 75 80 85

cgc?gac?ctc?cct?gat?acc?cca?acc?ctt?ttt?gtt?aag?ttc?cct?gac?gcg 403

Arg?Asp?Leu?Pro?Asp?Thr?Pro?Thr?Leu?Phe?Val?Lys?Phe?Pro?Asp?Ala

90 95 100

ctc?atc?gga?cct?ttc?gat?gat?gtt?gtc?gtt?cca?gag?tgg?gct?aac?aag 451

Leu?Ile?Gly?Pro?Phe?Asp?Asp?Val?Val?Val?Pro?Glu?Trp?Ala?Asn?Lys

105 110 115

gct?ctc?gac?tgg?gaa?ggc?gag?atg?gca?gtt?atc?att?ggc?aag?cgc?gca 499

Ala?Leu?Asp?Trp?Glu?Gly?Glu?Met?Ala?Val?Ile?Ile?Gly?Lys?Arg?Ala

120 125 130

cgc?cgt?gtc?aag?cag?gcc?gat?gct?gct?gag?tac?atc?gct?ggc?tac?gca 547

Arg?Arg?Val?Lys?Gln?Ala?Asp?Ala?Ala?Glu?Tyr?Ile?Ala?Gly?Tyr?Ala

135 140 145

gtg?atg?aac?gat?tac?acc?acc?cgc?gat?ttc?cag?tac?gca?gca?cct?gca 595

Val?Met?Asn?Asp?Tyr?Thr?Thr?Arg?Asp?Phe?Gln?Tyr?Ala?Ala?Pro?Ala

150 155 160 165

aag?act?cca?cag?tgg?cac?cag?ggc?aag?tct?ttg?gaa?aag?tcc?gct?ggc 643

Lys?Thr?Pro?Gln?Trp?His?Gln?Gly?Lys?Ser?Leu?Glu?Lys?Ser?Ala?Gly

170 175 180

ttc?ggg?cct?tgg?atg?act?acc?cca?gat?tct?ttt?gag?ttc?ggc?ggc?gag 691

Phe?Gly?Pro?Trp?Met?Thr?Thr?Pro?Asp?Ser?Phe?Glu?Phe?Gly?Gly?Glu

185 190 195

ctg?gca?acc?tac?ctc?gag?ggc?gag?aag?gta?cag?tcc?acc?cct?acc?aat 739

Leu?Ala?Thr?Tyr?Leu?Glu?Gly?Glu?Lys?Val?Gln?Ser?Thr?Pro?Thr?Asn

200 205 210

gac?ctg?gtc?ttt?agc?cca?gaa?aag?ctc?atc?gaa?tac?atc?acc?cac?atc 787

Asp?Leu?Val?Phe?Ser?Pro?Glu?Lys?Leu?Ile?Glu?Tyr?Ile?Thr?His?Ile

215 220 225

tac?cca?ttg?gat?gct?ggc?gac?gtc?att?gtc?acc?ggt?acc?cca?ggc?ggc 835

Tyr?Pro?Leu?Asp?Ala?Gly?Asp?Val?Ile?Val?Thr?Gly?Thr?Pro?Gly?Gly

230 235 240 245

gtt?ggc?cac?gca?cgt?aac?cca?cag?cgc?tac?atc?ggt?gac?ggc?gaa?acc 883

Val?Gly?His?Ala?Arg?Asn?Pro?Gln?Arg?Tyr?Ile?Gly?Asp?Gly?Glu?Thr

250 255 260

gta?aag?gtt?gag?att?gcg?ggc?ctc?ggc?ttc?att?gaa?aac?aag?acg?gtg 931

Val?Lys?Val?Glu?Ile?Ala?Gly?Leu?Gly?Phe?Ile?Glu?Asn?Lys?Thr?Val

265 270 275

ttt?gaa?taaatgacaa?ctttccacga?tct 960

Phe?Glu

<210>426

<211>279

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>426

Met?Arg?Leu?Ala?Thr?Ile?Arg?Thr?Asn?Gly?Thr?Thr?Ile?Ala?Ala?Arg

1 5 10 15

Val?Glu?Ser?Glu?Asn?Thr?Ala?Thr?Thr?Ile?Glu?Gly?Phe?Ala?Asn?Val

20 25 30

Gly?Glu?Leu?Leu?Gln?Glu?Ser?Asn?Trp?Arg?Glu?Leu?Ala?Glu?Asn?Ala

35 40 45

Ala?Gly?Glu?Ala?Val?Thr?Phe?Glu?Asn?Lys?Glu?Leu?Asp?Ala?Val?Val

50 55 60

Pro?Ala?Pro?Lys?Lys?Ile?Val?Cys?Val?Gly?Leu?Asn?Tyr?Ala?Asn?His

65 70 75 80

Ile?Lys?Glu?Met?Gly?Arg?Asp?Leu?Pro?Asp?Thr?Pro?Thr?Leu?Phe?Val

85 90 95

Lys?Phe?Pro?Asp?Ala?Leu?Ile?Gly?Pro?Phe?Asp?Asp?Val?Val?Val?Pro

100 105 110

Glu?Trp?Ala?Asn?Lys?Ala?Leu?Asp?Trp?Glu?Gly?Glu?Met?Ala?Val?Ile

115 120 125

Ile?Gly?Lys?Arg?Ala?Arg?Arg?Val?Lys?Gln?Ala?Asp?Ala?Ala?Glu?Tyr

130 135 140

Ile?Ala?Gly?Tyr?Ala?Val?Met?Asn?Asp?Tyr?Thr?Thr?Arg?Asp?Phe?Gln

145 150 155 160

Tyr?Ala?Ala?Pro?Ala?Lys?Thr?Pro?Gln?Trp?His?Gln?Gly?Lys?Ser?Leu

165 170 175

Glu?Lys?Ser?Ala?Gly?Phe?Gly?Pro?Trp?Met?Thr?Thr?Pro?Asp?Ser?Phe

180 185 190

Glu?Phe?Gly?Gly?Glu?Leu?Ala?Thr?Tyr?Leu?Glu?Gly?Glu?Lys?Val?Gln

195 200 205

Ser?Thr?Pro?Thr?Asn?Asp?Leu?Val?Phe?Ser?Pro?Glu?Lys?Leu?Ile?Glu

210 215 220

Tyr?Ile?Thr?His?Ile?Tyr?Pro?Leu?Asp?Ala?Gly?Asp?Val?Ile?Val?Thr

225 230 235 240

Gly?Thr?Pro?Gly?Gly?Val?Gly?His?Ala?Arg?Asn?Pro?Gln?Arg?Tyr?Ile

245 250 255

Gly?Asp?Gly?Glu?Thr?Val?Lys?Val?Glu?Ile?Ala?Gly?Leu?Gly?Phe?Ile

260 265 270

Glu?Asn?Lys?Thr?Val?Phe?Glu

275

<210>427

<211>1101

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1078)

<223>RXN00299

<400>427

tgccatcggt?ttggctattg?attggaacaa?gaaaggtgcc?cagtctgttg?caaagaagga?60

atccatttcc?gtctaatcgc?taattgcgag?gagtctttgc?atg?tct?atc?cca?ctt 115

Met?Ser?Ile?Pro?Leu

1 5

tca?ctg?att?gat?ttt?gcc?acc?att?ttt?gag?ggc?gaa?agg?cct?ggt?gac 163

Ser?Leu?Ile?Asp?Phe?Ala?Thr?Ile?Phe?Glu?Gly?Glu?Arg?Pro?Gly?Asp

10 15 20

agc?ttc?aaa?cga?tca?gtg?gca?ttg?gcg?caa?aaa?gct?gaa?ggt?tta?ggc 211

Ser?Phe?Lys?Arg?Ser?Val?Ala?Leu?Ala?Gln?Lys?Ala?Glu?Gly?Leu?Gly

25 30 35

ttc?aag?cgc?att?tgg?tac?gca?gag?cat?cac?aac?atg?gag?agc?att?tct 259

Phe?Lys?Arg?Ile?Trp?Tyr?Ala?Glu?His?His?Asn?Met?Glu?Ser?Ile?Ser

40 45 50

tca?gct?gct?cct?gca?gtg?ctt?att?tct?cac?atc?ggt?gcg?aac?acc?aag 307

Ser?Ala?Ala?Pro?Ala?Val?Leu?Ile?Ser?His?Ile?Gly?Ala?Asn?Thr?Lys

55 60 65

act?att?cgt?ctg?ggt?gcc?ggc?ggc?gtc?atg?ctg?ccc?aac?cac?tcc?cca 355

Thr?Ile?Arg?Leu?Gly?Ala?Gly?Gly?Val?Met?Leu?Pro?Asn?His?Ser?Pro

70 75 80 85

tat?gtc?atc?gct?gag?cag?ttc?ggc?acc?ttg?gcg?gag?ttg?tac?cca?gac 403

Tyr?Val?Ile?Ala?Glu?Gln?Phe?Gly?Thr?Leu?Ala?Glu?Leu?Tyr?Pro?Asp

90 95 100

cgc?atc?gac?ctc?ggc?ctg?ggc?cgt?gcc?cct?ggc?acg?gac?atg?aat?acc 451

Arg?Ile?Asp?Leu?Gly?Leu?Gly?Arg?Ala?Pro?Gly?Thr?Asp?Met?Asn?Thr

105 110 115

ttg?cgc?gct?tta?cga?cgc?gac?cct?cag?tcc?gcc?gag?aac?ttc?ccg?tcc 499

Leu?Arg?Ala?Leu?Arg?Arg?Asp?Pro?Gln?Ser?Ala?Glu?Asn?Phe?Pro?Ser

120 125 130

gac?gtt?gtc?gag?ctg?aac?tct?tac?ctc?acc?ggc?cgt?tcc?cgt?ctc?cca 547

Asp?Val?Val?Glu?Leu?Asn?Ser?Tyr?Leu?Thr?Gly?Arg?Ser?Arg?Leu?Pro

135 140 145

ggg?gtt?aac?gca?att?cca?ggc?aag?ggc?acc?aac?gta?ccg?ctg?tac?atc 595

Gly?Val?Asn?Ala?Ile?Pro?Gly?Lys?Gly?Thr?Asn?Val?Pro?Leu?Tyr?Ile

150 155 160 165

ttg?ggt?tca?tcc?ctc?ttt?ggt?gca?caa?ttg?gca?gca?cag?ttg?ggt?atg 643

Leu?Gly?Ser?Ser?Leu?Phe?Gly?Ala?Gln?Leu?Ala?Ala?Gln?Leu?Gly?Met

170 175 180

cct?tat?tcc?ttc?gca?tcc?cac?ttc?gca?cca?act?cac?ctt?gag?cac?gcg 691

Pro?Tyr?Ser?Phe?Ala?Ser?His?Phe?Ala?Pro?Thr?His?Leu?Glu?His?Ala

185 190 195

gtg?caa?acc?tac?cgg?gat?aac?tac?cag?cct?tca?gag?cag?cat?cct?gag 739

Val?Gln?Thr?Tyr?Arg?Asp?Asn?Tyr?Gln?Pro?Ser?Glu?Gln?His?Pro?Glu

200 205 210

cct?tat?gtc?att?gcg?gcc?gtc?aat?gtc?acc?gca?tct?gat?tcc?act?gaa 787

Pro?Tyr?Val?Ile?Ala?Ala?Val?Asn?Val?Thr?Ala?Ser?Asp?Ser?Thr?Glu

215 220 225

caa?gcc?cac?gat?gat?ttc?tac?aag?gta?gcg?cgt?gca?cgc?gtg?aag?aac 835

Gln?Ala?His?Asp?Asp?Phe?Tyr?Lys?Val?Ala?Arg?Ala?Arg?Val?Lys?Asn

230 235 240 245

atg?gca?ttg?cgt?ggc?cga?caa?gtt?act?gat?gag?caa?ctt?gat?gaa?ctc 883

Met?Ala?Leu?Arg?Gly?Arg?Gln?Val?Thr?Asp?Glu?Gln?Leu?Asp?Glu?Leu

250 255 260

atg?gat?tca?cca?gct?gct?cgc?caa?att?gtc?gac?atg?ctt?cac?tac?acc 931

Met?Asp?Ser?Pro?Ala?Ala?Arg?Gln?Ile?Val?Asp?Met?Leu?His?Tyr?Thr

265 270 275

gct?ata?ggc?act?gga?tcc?gaa?gtt?aaa?gaa?tac?cta?gac?ggt?ttt?gta 979

Ala?Ile?Gly?Thr?Gly?Ser?Glu?Val?Lys?Glu?Tyr?Leu?Asp?Gly?Phe?Val

280 285 290

aag?acg?gca?cag?gct?gat?gaa?ctg?atg?atc?tcc?ctg?caa?tcc?ccc?aac 1027

Lys?Thr?Ala?Gln?Ala?Asp?Glu?Leu?Met?Ile?Ser?Leu?Gln?Ser?Pro?Asn

295 300 305

act?gaa?gca?acc?acg?cgc?aat?atg?gaa?att?ctt?gcg?gat?gcg?tgg?att 1075

Thr?Glu?Ala?Thr?Thr?Arg?Asn?Met?Glu?Ile?Leu?Ala?Asp?Ala?Trp?Ile

310 315 320 325

aat?tagtaccgat?gggccggtag?aca 1101

Asn

<210>428

<211>326

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>428

Met?Ser?Ile?Pro?Leu?Ser?Leu?Ile?Asp?Phe?Ala?Thr?Ile?Phe?Glu?Gly

1 5 10 15

Glu?Arg?Pro?Gly?Asp?Ser?Phe?Lys?Arg?Ser?Val?Ala?Leu?Ala?Gln?Lys

20 25 30

Ala?Glu?Gly?Leu?Gly?Phe?Lys?Arg?Ile?Trp?Tyr?Ala?Glu?His?His?Asn

35 40 45

Met?Glu?Ser?Ile?Ser?Ser?Ala?Ala?Pro?Ala?Val?Leu?Ile?Ser?His?Ile

50 55 60

Gly?Ala?Asn?Thr?Lys?Thr?Ile?Arg?Leu?Gly?Ala?Gly?Gly?Val?Met?Leu

65 70 75 80

Pro?Asn?His?Ser?Pro?Tyr?Val?Ile?Ala?Glu?Gln?Phe?Gly?Thr?Leu?Ala

85 90 95

Glu?Leu?Tyr?Pro?Asp?Arg?Ile?Asp?Leu?Gly?Leu?Gly?Arg?Ala?Pro?Gly

100 105 110

Thr?Asp?Met?Asn?Thr?Leu?Arg?Ala?Leu?Arg?Arg?Asp?Pro?Gln?Ser?Ala

115 120 125

Glu?Asn?Phe?Pro?Ser?Asp?Val?Val?Glu?Leu?Asn?Ser?Tyr?Leu?Thr?Gly

130 135 140

Arg?Ser?Arg?Leu?Pro?Gly?Val?Asn?Ala?Ile?Pro?Gly?Lys?Gly?Thr?Asn

145 150 155 160

Val?Pro?Leu?Tyr?Ile?Leu?Gly?Ser?Ser?Leu?Phe?Gly?Ala?Gln?Leu?Ala

165 170 175

Ala?Gln?Leu?Gly?Met?Pro?Tyr?Ser?Phe?Ala?Ser?His?Phe?Ala?Pro?Thr

180 185 190

His?Leu?Glu?His?Ala?Val?Gln?Thr?Tyr?Arg?Asp?Asn?Tyr?Gln?Pro?Ser

195 200 205

Glu?Gln?His?Pro?Glu?Pro?Tyr?Val?Ile?Ala?Ala?Val?Asn?Val?Thr?Ala

210 215 220

Ser?Asp?Ser?Thr?Glu?Gln?Ala?His?Asp?Asp?Phe?Tyr?Lys?Val?Ala?Arg

225 230 235 240

Ala?Arg?Val?Lys?Asn?Met?Ala?Leu?Arg?Gly?Arg?Gln?Val?Thr?Asp?Glu

245 250 255

Gln?Leu?Asp?Glu?Leu?Met?Asp?Ser?Pro?Ala?Ala?Arg?Gln?Ile?Val?Asp

260 265 270

Met?Leu?His?Tyr?Thr?Ala?Ile?Gly?Thr?Gly?Ser?Glu?Val?Lys?Glu?Tyr

275 280 285

Leu?Asp?Gly?Phe?Val?Lys?Thr?Ala?Gln?Ala?Asp?Glu?Leu?Met?Ile?Ser

290 295 300

Leu?Gln?Ser?Pro?Asn?Thr?Glu?Ala?Thr?Thr?Arg?Asn?Met?Glu?Ile?Leu

305 310 315 320

Ala?Asp?Ala?Trp?Ile?Asn

325

<210>429

<211>784

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(l8)..(761)

<223>FRXA00299

<400>429

gggtgccggc?ggcggtc?atg?ctg?ccc?aac?cac?tcc?cea?tat?gtc?atc?gct?gag?53

Met?Leu?Pro?Asn?His?Ser?Pro?Tyr?Val?Ile?Ala?Glu

1 5 10

cag?ttc?ggc?acc?ttg?gcg?gag?ttg?tac?cca?gac?cgc?atc?gac?ctc?ggc 101

Gln?Phe?Gly?Thr?Leu?Ala?Glu?Leu?Tyr?Pro?Asp?Arg?Ile?Asp?Leu?Gly

15 20 25

atg?ggc?cgt?gcc?cct?ggc?acg?gac?atg?aat?acc?ttg?cgc?gct?tta?cga 149

Met?Gly?Arg?Ala?Pro?Gly?Thr?Asp?Met?Asn?Thr?Leu?Arg?Ala?Leu?Arg

30 35 40

cgc?gac?cct?cag?tcc?gcc?gag?aac?ttc?ccg?tcc?gac?gtt?gtc?gag?ctg 197

Arg?Asp?Pro?Gln?Ser?Ala?Glu?Asn?Phe?Pro?Ser?Asp?Val?Val?Glu?Leu

45 50 55 60

aac?tct?tac?ctc?acc?ggc?cgt?tcc?cgt?ctc?cca?ggg?gtt?aac?gca?att 245

Asn?Ser?Tyr?Leu?Thr?Gly?Arg?Ser?Arg?Leu?Pro?Gly?Val?Asn?Ala?Ile

65 70 75

cca?ggc?aag?ggc?acc?aac?gta?ccg?ctg?tac?atc?ttg?ggt?tca?tcc?ctc 293

Pro?Gly?Lys?Gly?Thr?Asn?Val?Pro?Leu?Tyr?Ile?Leu?Gly?Ser?Ser?Leu

80 85 90

ttt?ggt?gca?caa?ttg?gca?gca?cag?ttg?ggt?atg?cct?tat?tcc?ttc?gca 341

Phe?Gly?Ala?Gln?Leu?Ala?Ala?Gln?Leu?Gly?Met?Pro?Tyr?Ser?Phe?Ala

95 100 105

tcc?cac?ttc?gca?cca?act?cac?ctt?gag?cac?gcg?gtg?caa?acc?tac?cgg 389

Ser?His?Phe?Ala?Pro?Thr?His?Leu?Glu?His?Ala?Val?Gln?Thr?Tyr?Arg

110 115 120

gat?aac?tac?cag?cct?tca?gag?cag?cat?cct?gag?cct?tat?gtc?att?gcg 437

Asp?Asn?Tyr?Gln?Pro?Ser?Glu?Gln?His?Pro?Glu?Pro?Tyr?Val?Ile?Ala

125 130 135 140

gcc?gtc?aat?gtc?acc?gca?tct?gat?tcc?act?gaa?caa?gcc?cac?gat?gat 485

Ala?Val?Asn?Val?Thr?Ala?Ser?Asp?Ser?Thr?Glu?Gln?Ala?His?Asp?Asp

145 150 155

ttc?tac?aag?gta?gcg?cgt?gca?cgc?gtg?aag?aac?atg?gca?ttg?cgt?ggc 533

Phe?Tyr?Lys?Val?Ala?Arg?Ala?Arg?Val?Lys?Asn?Met?Ala?Leu?Arg?Gly

160 165 170

cga?caa?gtt?act?gat?gag?caa?ctt?gat?gaa?ctc?atg?gat?tca?cca?gct 581

Arg?Gln?Val?Thr?Asp?Glu?Gln?Leu?Asp?Glu?Leu?Met?Asp?Ser?Pro?Ala

175 180 185

gct?cgc?caa?att?gtc?gac?atg?ctt?cac?tac?acc?gct?ata?ggc?act?gga 629

Ala?Arg?Gln?Ile?Val?Asp?Met?Leu?His?Tyr?Thr?Ala?Ile?Gly?Thr?Gly

190 195 200

tcc?gaa?gtt?aaa?gaa?tac?cta?gac?ggt?ttt?gta?aag?acg?gca?cag?gct 677

Ser?Glu?Val?Lys?Glu?Tyr?Leu?Asp?Gly?Phe?Val?Lys?Thr?Ala?Gln?Ala

205 210 215 220

gat?gaa?ctg?atg?atc?tcc?ctg?caa?tcc?ccc?aac?act?gaa?gca?acc?acg 725

Asp?Glu?Leu?Met?Ile?Ser?Leu?Gln?Ser?Pro?Asn?Thr?Glu?Ala?Thr?Thr

225 230 235

cgc?aat?atg?gaa?att?ctt?gcg?gat?gcg?tgg?att?aat?tagtaccgat 771

Arg?Asn?Met?Glu?Ile?Leu?Ala?Asp?Ala?Trp?Ile?Asn

240 245

gggccggtag?aca 784

<210>430

<211>248

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>430

Met?Leu?Pro?Asn?His?Ser?Pro?Tyr?Val?Ile?Ala?Glu?Gln?Phe?Gly?Thr

1 5 10 15

Leu?Ala?Glu?Leu?Tyr?Pro?Asp?Arg?Ile?Asp?Leu?Gly?Met?Gly?Arg?Ala

20 25 30

Pro?Gly?Thr?Asp?Met?Asn?Thr?Leu?Arg?Ala?Leu?Arg?Arg?Asp?Pro?Gln

35 40 45

Ser?Ala?Glu?Asn?Phe?Pro?Ser?Asp?Val?Val?Glu?Leu?Asn?Ser?Tyr?Leu

50 55 60

Thr?Gly?Arg?Ser?Arg?Leu?Pro?Gly?Val?Asn?Ala?Ile?Pro?Gly?Lys?Gly

65 70 75 80

Thr?Asn?Val?Pro?Leu?Tyr?Ile?Leu?Gly?Ser?Ser?Leu?Phe?Gly?Ala?Gln

85 90 95

Leu?Ala?Ala?Gln?Leu?Gly?Met?Pro?Tyr?Ser?Phe?Ala?Ser?His?Phe?Ala

100 105 110

Pro?Thr?His?Leu?Glu?His?Ala?Val?Gln?Thr?Tyr?Arg?Asp?Asn?Tyr?Gln

115 120 125

Pro?Ser?Glu?Gln?His?Pro?Glu?Pro?Tyr?Val?Ile?Ala?Ala?Val?Asn?Val

130 135 140

Thr?Ala?Ser?Asp?Ser?Thr?Glu?Gln?Ala?His?Asp?Asp?Phe?Tyr?Lys?Val

145 150 155 160

Ala?Arg?Ala?Arg?Val?Lys?Asn?Met?Ala?Leu?Arg?Gly?Arg?Gln?Val?Thr

165 170 175

Asp?Glu?Gln?Leu?Asp?Glu?Leu?Met?Asp?Ser?Pro?Ala?Ala?Arg?Gln?Ile

180 185 190

Val?Asp?Met?Leu?His?Tyr?Thr?Ala?Ile?Gly?Thr?Gly?Ser?Glu?Val?Lys

195 200 205

Glu?Tyr?Leu?Asp?Gly?Phe?Val?Lys?Thr?Ala?Gln?Ala?Asp?Glu?Leu?Met

210 215 220

Ile?Ser?Leu?Gln?Ser?Pro?Asn?Thr?Glu?Ala?Thr?Thr?Arg?Asn?Met?Glu

225 230 235 240

Ile?Leu?Ala?Asp?Ala?Trp?Ile?Asn

245

<210>431

<211>825

<212>DNA

＜213〉Corynebacterium glutamicum (C0rynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(802)

<223>RXA00332

<400>431

aatgaactct?ggaaccgcca?tgcagcaaaa?cctctccaat?tggtaatctt?tgactcccag?60

gttacgccag?ccctgcgaca?ccaccatcta?gggttagagt?atg?gcc?ttc?aac?aaa 115

Met?Ala?Phe?Asn?Lys

1 5

gcg?tac?gat?gca?ctt?cgc?gcc?cct?caa?atc?acc?ctc?gga?ctc?atg?aca 163

Ala?Tyr?Asp?Ala?Leu?Arg?Ala?Pro?Gln?Ile?Thr?Leu?Gly?Leu?Met?Thr

10 15 20

cca?aac?ggc?cct?gaa?cta?ggg?cgc?agt?gaa?atg?gtt?cca?acc?gaa?aat 211

Pro?Asn?Gly?Pro?Glu?Leu?Gly?Arg?Ser?Glu?Met?Val?Pro?Thr?Glu?Asn

25 30 35

agc?atc?gaa?cta?gcc?ata?caa?gca?gaa?gct?caa?gga?ttc?aga?ggc?atg 259

Ser?Ile?Glu?Leu?Ala?Ile?Gln?Ala?Glu?Ala?Gln?Gly?Phe?Arg?Gly?Met

40 45 50

tgg?gtt?cga?gac?gtt?cca?ctc?gca?gtt?cct?caa?gga?atc?act?gtt?acc 307

Trp?Val?Arg?Asp?Val?Pro?Leu?Ala?Val?Pro?Gln?Gly?Ile?Thr?Val?Thr

55 60 65

gat?aaa?cag?gct?acg?tat?tta?gat?gat?cca?ttc?tta?atg?ctc?ggt?gcg 355

Asp?Lys?Gln?Ala?Thr?Tyr?Leu?Asp?Asp?Pro?Phe?Leu?Met?Leu?Gly?Ala

70 75 80 85

atg?gcc?tct?gtg?acc?tct?aca?atc?gcg?ctg?ggc?act?gca?gcg?acc?gtg 403

Met?Ala?Ser?Val?Thr?Ser?Thr?Ile?Ala?Leu?Gly?Thr?Ala?Ala?Thr?Val

90 95 100

ctt?cca?ctc?aga?cat?ccg?cta?cat?gtg?gcg?aaa?tcc?gcg?ctc?acc?ctt 451

Leu?Pro?Leu?Arg?His?Pro?Leu?His?Val?Ala?Lys?Ser?Ala?Leu?Thr?Leu

105 110 115

gat?cga?ctc?agc?cac?gga?cgt?ttc?gtt?tta?ggc?atc?ggc?tct?ggc?gac 499

Asp?Arg?Leu?Ser?His?Gly?Arg?Phe?Val?Leu?Gly?Ile?Gly?Ser?Gly?Asp

120 125 130

agg?cct?gaa?gaa?ttc?gag?att?ttt?ggc?aaa?agc?tta?gac?aat?cga?cgc 547

Arg?Pro?Glu?Glu?Phe?Glu?Ile?Phe?Gly?Lys?Ser?Leu?Asp?Asn?Arg?Arg

135 140 145

gct?gat?att?cag?tct?ggg?tgg?gca?att?ttg?cgt?gca?gct?ttg?tcg?ccg 595

Ala?Asp?Ile?Gln?Ser?Gly?Trp?Ala?Ile?Leu?Arg?Ala?Ala?Leu?Ser?Pro

150 155 160 165

gat?cct?gcg?atg?cgg?gcc?gac?ctt?gaa?ttt?gcg?cca?acc?acg?cca?cct 643

Asp?Pro?Ala?Met?Arg?Ala?Asp?Leu?Glu?Phe?Ala?Pro?Thr?Thr?Pro?Pro

170 175 180

gaa?gct?cag?atc?ccc?atg?atc?gct?gta?ggt?tct?gcc?cga?caa?aca?gtg 691

Glu?Ala?Gln?Ile?Pro?Met?Ile?Ala?Val?Gly?Ser?Ala?Arg?Gln?Thr?Val

185 190 195

caa?tgg?atc?gcc?cga?aac?gcc?gac?gga?tgg?gca?acc?tac?tac?cgc?ccc 739

Gln?Trp?Ile?Ala?Arg?Asn?Ala?Asp?Gly?Trp?Ala?Thr?Tyr?Tyr?Arg?Pro

200 205 210

gct?gaa?gct?caa?gtc?gga?cgc?ctc?gat?ctc?tgg?gac?aaa?gcc?cgt?ggt 787

Ala?Glu?Ala?Gln?Val?Gly?Arg?Leu?Asp?Leu?Trp?Asp?Lys?Ala?Arg?Gly

215 220 225

ggc?acc?cgc?cct?tgt?tgatttcctc?catggggctc?aac 825

Gly?Thr?Arg?Pro?Cys

230

<210>432

<211>234

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>432

Met?Ala?Phe?Asn?Lys?Ala?Tyr?Asp?Ala?Leu?Arg?Ala?Pro?Gln?Ile?Thr

1 5 10 15

Leu?Gly?Leu?Met?Thr?Pro?Asn?Gly?Pro?Glu?Leu?Gly?Arg?Ser?Glu?Met

20 25 30

Val?Pro?Thr?Glu?Asn?Ser?Ile?Glu?Leu?Ala?Ile?Gln?Ala?Glu?Ala?Gln

35 40 45

Gly?Phe?Arg?Gly?Met?Trp?Val?Arg?Asp?Val?Pro?Leu?Ala?Val?Pro?Gln

50 55 60

Gly?Ile?Thr?Val?Thr?Asp?Lys?Gln?Ala?Thr?Tyr?Leu?Asp?Asp?Pro?Phe

65 70 75 80

Leu?Met?Leu?Gly?Ala?Met?Ala?Ser?Val?Thr?Ser?Thr?Ile?Ala?Leu?Gly

85 90 95

Thr?Ala?Ala?Thr?Val?Leu?Pro?Leu?Arg?His?Pro?Leu?His?Val?Ala?Lys

100 105 110

Ser?Ala?Leu?Thr?Leu?Asp?Arg?Leu?Ser?His?Gly?Arg?Phe?Val?Leu?Gly

115 120 125

Ile?Gly?Ser?Gly?Asp?Arg?Pro?Glu?Glu?Phe?Clu?Ile?Phe?Gly?Lys?Ser

130 135 140

Leu?Asp?Asn?Arg?Arg?Ala?Asp?Ile?Gln?Ser?Gly?Trp?Ala?Ile?Leu?Arg

145 150 155 160

Ala?Ala?Leu?Ser?Pro?Asp?Pro?Ala?Met?Arg?Ala?Asp?Leu?Glu?Phe?Ala

165 170 175

Pro?Thr?Thr?Pro?Pro?Glu?Ala?Gln?Ile?Pro?Met?Ile?Ala?Val?Gly?Ser

180 185 190

Ala?Arg?Gln?Thr?Val?Gln?Trp?Ile?Ala?Arg?Asn?Ala?Asp?Gly?Trp?Ala

195 200 205

Thr?Tyr?Tyr?Arg?Pro?Ala?Glu?Ala?Gln?Val?Gly?Arg?Leu?Asp?Leu?Trp

210 215 220

Asp?Lys?Ala?Arg?Gly?Gly?Thr?Arg?Pro?Cys

225 230

<210>433

<211>842

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(1)..(8l9)

<223>RXA01838

<400>433

cag?cac?ctc?tcc?ggc?ggc?cgt?gtt?gac?ctt?atg?atg?ggc?cgt?ggc?aac 48

Gln?His?Leu?Ser?Gly?Gly?Arg?Val?Asp?Leu?Met?Met?Gly?Arg?Gly?Asn

1 5 10 15

acc?gga?ccc?gtt?tac?cca?tgg?ttt?ggc?aaa?gac?atc?cac?caa?ggc?atc 96

Thr?Gly?Pro?Val?Tyr?Pro?Trp?Phe?Gly?Lys?Asp?Ile?His?Gln?Gly?Ile

20 25 30

cca?cta?gcg?att?gaa?aac?tac?cac?ctc?ctg?cgc?cgc?ctc?tgg?cgc?gaa 144

Pro?Leu?Ala?Ile?Glu?Asn?Tyr?His?Leu?Leu?Arg?Arg?Leu?Trp?Arg?Glu

35 40 45

gac?gta?gtc?aac?tgg?cag?ggc?aaa?ttc?cgc?aca?ccg?ttg?cag?gga?tac 192

Asp?Val?Val?Asn?Trp?Gln?Gly?Lys?Phe?Arg?Thr?Pro?Leu?Gln?Gly?Tyr

50 55 60

acc?tct?acc?cca?gca?cca?tta?gac?ggc?gtt?gca?cca?ttc?gtc?tgg?cac 240

Thr?Ser?Thr?Pro?Ala?Pro?Leu?Asp?Gly?Val?Ala?Pro?Phe?Val?Trp?His

65 70 75 80

ggc?tcc?atc?cgc?tcc?acc?gaa?atc?gca?gag?caa?gca?gcc?ttc?tat?ggc 288

Gly?Ser?Ile?Arg?Ser?Thr?Glu?Ile?Ala?Glu?Gln?Ala?Ala?Phe?Tyr?Gly

85 90 95

gac?ggc?ttc?ttc?cac?aac?aac?atc?ttc?tgg?aac?aaa?gag?cac?acc?gcc 336

Asp?Gly?Phe?Phe?His?Asn?Asn?Ile?Phe?Trp?Asn?Lys?Glu?His?Thr?Ala

100 105 110

caa?atg?gtc?aac?ctc?tac?cgc?cag?cgt?ttc?gaa?cac?tac?gga?cac?ggc 384

Gln?Met?Val?Asn?Leu?Tyr?Arg?Gln?Arg?Phe?Glu?His?Tyr?Gly?His?Gly

115 120 125

caa?gca?gac?cag?gcc?atc?gtg?gga?ctc?ggt?ggc?caa?gtc?ttc?atc?ggc 432

Gln?Ala?Asp?Gln?Ala?Ile?Val?Gly?Leu?Gly?Gly?Gln?Val?Phe?Ile?Gly

130 135 140

gat?tct?gaa?gaa?gaa?gca?aag?aag?acc?ttc?cgc?ccc?tac?ttc?gac?aac 480

Asp?Ser?Glu?Glu?Glu?Ala?Lys?Lys?Thr?Phe?Arg?Pro?Tyr?Phe?Asp?Asn

145 150 155 160

gcc?cct?gtc?tac?gga?cac?gga?cca?tca?ctt?gaa?gat?ttc?tcc?cgc?ctg 528

Ala?Pro?Val?Tyr?Gly?His?Gly?Pro?Ser?Leu?Glu?Asp?Phe?Ser?Arg?Leu

165 170 175

acc?cca?cta?acc?gtc?ggt?acc?gct?gag?caa?gtt?atc?gaa?cgc?acc?atg 576

Thr?Pro?Leu?Thr?Val?Gly?Thr?Ala?Glu?Gln?Val?Ile?Glu?Arg?Thr?Met

180 185 190

gaa?ttc?gcc?gac?tgg?gta?ggc?gat?tac?cag?cgc?cag?ctc?ttc?ctc?atc 624

Glu?Phe?Ala?Asp?Trp?Val?Gly?Asp?Tyr?Gln?Arg?Gln?Leu?Phe?Leu?Ile

195 200 205

gac?cac?gcc?ggc?ctg?cca?cta?gaa?atg?gtc?ctt?gat?cag?atc?gaa?cgc 672

Asp?His?Ala?Gly?Leu?Pro?Leu?Glu?Met?Val?Leu?Asp?Gln?Ile?Glu?Arg

210 215 220

ctc?ggc?cac?gat?gtc?gtc?cca?gag?gta?cgc?cgc?cgc?atg?gag?gag?cgt 720

Leu?Gly?His?Asp?Val?Val?Pro?Glu?Val?Arg?Arg?Arg?Met?Glu?Glu?Arg

225 230 235 240

cgc?cca?gac?cac?gtt?ccc?tcc?aac?cca?cca?acc?cac?cag?agc?ctg?aag 768

Arg?Pro?Asp?His?Val?Pro?Ser?Asn?Pro?Pro?Thr?His?Gln?Ser?Leu?Lys

245 250 255

gcc?aac?cga?aac?agc?cct?tac?ttt?cag?atc?aac?cct?ggt?cag?cca?act 816

Ala?Asn?Arg?Asn?Ser?Pro?Tyr?Phe?Gln?Ile?Asn?Pro?Gly?Gln?Pro?Thr

260 265 270

gag?tagtttttct?gaaactaagg?aga 842

Glu

<210>434

<211>273

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>434

Gln?His?Leu?Ser?Gly?Gly?Arg?Val?Asp?Leu?Met?Met?Gly?Arg?Gly?Asn

1 5 10 15

Thr?Gly?Pro?Val?Tyr?Pro?Trp?Phe?Gly?Lys?Asp?Ile?His?Gln?Gly?Ile

20 25 30

Pro?Leu?Ala?Ile?Glu?Asn?Tyr?His?Leu?Leu?Arg?Arg?Leu?Trp?Arg?Glu

35 40 45

Asp?Val?Val?Asn?Trp?Gln?Gly?Lys?Phe?Arg?Thr?Pro?Leu?Gln?Gly?Tyr

50 55 60

Thr?Ser?Thr?Pro?Ala?Pro?Leu?Asp?Gly?Val?Ala?Pro?Phe?Val?Trp?His

65 70 75 80

Gly?Ser?Ile?Arg?Ser?Thr?Glu?Ile?Ala?Glu?Gln?Ala?Ala?Phe?Tyr?Gly

85 90 95

Asp?Gly?Phe?Phe?His?Asn?Asn?Ile?Phe?Trp?Asn?Lys?Glu?His?Thr?Ala

100 105 110

Gln?Met?Val?Asn?Leu?Tyr?Arg?Gln?Arg?Phe?Glu?His?Tyr?Gly?His?Gly

115 120 125

Gln?Ala?Asp?Gln?Ala?Ile?Val?Gly?Leu?Gly?Gly?Gln?Val?Phe?Ile?Gly

130 135 140

Asp?Ser?Glu?Glu?Glu?Ala?Lys?Lys?Thr?Phe?Arg?Pro?Tyr?Phe?Asp?Asn

145 150 155 160

Ala?Pro?Val?Tyr?Gly?His?Gly?Pro?Ser?Leu?Glu?Asp?Phe?Ser?Arg?Leu

165 170 175

Thr?Pro?Leu?Thr?Val?Gly?Thr?Ala?Glu?Gln?Val?Ile?Glu?Arg?Thr?Met

180 185 190

Glu?Phe?Ala?Asp?Trp?Val?Gly?Asp?Tyr?Gln?Arg?Gln?Leu?Phe?Leu?Ile

195 200 205

Asp?His?Ala?Gly?Leu?Pro?Leu?Glu?Met?Val?Leu?Asp?Gln?Ile?Glu?Arg

210 215 220

Leu?Gly?His?Asp?Val?Val?Pro?Glu?Val?Arg?Arg?Arg?Met?Glu?Glu?Arg

225 230 235 240

Arg?Pro?Asp?His?Val?Pro?Ser?Asn?Pro?Pro?Thr?His?Gln?Ser?Leu?Lys

245 250 255

Ala?Asn?Arg?Asn?Ser?Pro?Tyr?Phe?Gln?Ile?Asn?Pro?Gly?Gln?Pro?Thr

260 265 270

Glu

<210>435

<211>1167

<212>DNA

＜2l3〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1144)

<223>RXA02643

<400>435

tgagaacacc?taaaaacctt?gcgggaatac?caccaacccc?atattgttga?tatatctaca?60

aactctttta?ataagtctga?tcaacaacgt?gaggaaagca?atg?aaa?aac?gtc?tcc 115

Met?Lys?Asn?Val?Ser

1 5

ttc?ggc?ctc?gac?acc?ttc?ggc?gac?aac?gcc?atc?gac?ctg?cag?ggc?aac 163

Phe?Gly?Leu?Asp?Thr?Phe?Gly?Asp?Asn?Ala?Ile?Asp?Leu?Gln?Gly?Asn

10 15 20

ccg?gtc?tcc?cct?gca?caa?aca?ctt?cga?aac?atc?att?gat?gaa?gcc?aag 211

Pro?Val?Ser?Pro?Ala?Gln?Thr?Leu?Arg?Asn?Ile?Ile?Asp?Glu?Ala?Lys

25 30 35

atg?gca?gac?aaa?gtc?ggg?gtg?gat?atc?atc?ggc?atc?gga?gag?cac?cac 259

Met?Ala?Asp?Lys?Val?Gly?Val?Asp?Ile?Ile?Gly?Ile?Gly?Glu?His?His

40 45 50

cgt?gag?gaa?tac?tca?gtt?tct?gca?cct?gac?atc?gtc?atg?aca?gct?atc 307

Arg?Glu?Glu?Tyr?Ser?Val?Ser?Ala?Pro?Asp?Ile?Val?Met?Thr?Ala?Ile

55 60 65

ctc?gca?tcc?act?gag?cga?ctc?aaa?gtc?acc?tct?tcc?gtg?act?gtg?ctg 355

Leu?Ala?Ser?Thr?Glu?Arg?Leu?Lys?Val?Thr?Ser?Ser?Val?Thr?Val?Leu

70 75 80 85

tcc?tct?gat?gat?cct?gtt?cgc?ctg?ttt?gag?cgt?tat?tcc?acc?atg?aat 403

Ser?Ser?Asp?Asp?Pro?Val?Arg?Leu?Phe?Glu?Arg?Tyr?Ser?Thr?Met?Asn

90 95 100

gca?ctg?tcc?aac?ggt?cgc?gcc?gaa?atc?acc?ttg?gga?cgc?ggt?tcc?ttc 451

Ala?Leu?Ser?Asn?Gly?Arg?Ala?Glu?Ile?Thr?Leu?Gly?Arg?Gly?Ser?Phe

105 110 115

att?gag?tct?ttc?cca?ttg?ttt?ggt?ttt?gat?ctt?cag?gac?tac?gag?cag 499

Ile?Glu?Ser?Phe?Pro?Leu?Phe?Gly?Phe?Asp?Leu?Gln?Asp?Tyr?Glu?Gln

120 125 130

ctg?ttt?agt?gaa?cgc?ctt?gat?ttg?ttc?gcg?aag?att?ctt?gag?gcc?gac 547

Leu?Phe?Ser?Glu?Arg?Leu?Asp?Leu?Phe?Ala?Lys?Ile?Leu?Glu?Ala?Asp

135 140 145

agc?cgt?ggt?cag?ggc?gtg?acc?tgg?cat?ggt?gag?acc?cgc?tcg?gcg?ttg 595

Ser?Arg?Gly?Gln?Gly?Val?Thr?Trp?His?Gly?Glu?Thr?Arg?Ser?Ala?Leu

150 155 160 165

gaa?aac?cag?atg?ctt?tac?cca?cca?act?gag?aat?ggc?att?cac?gct?tgg 643

Glu?Asn?Gln?Met?Leu?Tyr?Pro?Pro?Thr?Glu?Asn?Gly?Ile?His?Ala?Trp

170 175 180

gtt?gca?gtg?ggt?ggc?agc?cca?gaa?tca?gtc?gtg?cgc?gct?gct?aag?tat 691

Val?Ala?Val?Gly?Gly?Ser?Pro?Glu?Ser?Val?Val?Arg?Ala?Ala?Lys?Tyr

185 190 195

cgt?ttc?ccg?ttg?atg?ctt?gcc?atc?atc?ggc?ggt?gct?cct?gag?cgt?ttc 739

Arg?Phe?Pro?Leu?Met?Leu?Ala?Ile?Ile?Gly?Gly?Ala?Pro?Glu?Arg?Phe

200 205 210

cgc?ccg?tat?gtg?gat?ctg?tac?aag?cgt?gcc?aac?gaa?cag?ttc?ggg?cag 787

Arg?Pro?Tyr?Val?Asp?Leu?Tyr?Lys?Arg?Ala?Asn?Glu?Gln?Phe?Gly?Gln

215 220 225

cct?caa?aag?ccc?att?ggt?gtg?cac?tcc?cct?gga?ctc?att?gcg?gca?act 835

Pro?Gln?Lys?Pro?Ile?Gly?Val?His?Ser?Pro?Gly?Leu?Ile?Ala?Ala?Thr

230 235 240 245

gat?gag?gaa?gcc?cgt?gag?cta?gca?ctt?aat?gat?tgg?ttg?gaa?ctc?caa 883

Asp?Glu?Glu?Ala?Arg?Glu?Leu?Ala?Leu?Asn?Asp?Trp?Leu?Glu?Leu?Gln

250 255 260

cgc?aag?atc?ggt?gct?gaa?cgc?ggt?tgg?gct?cct?gcg?gat?gca?atg?cag 931

Arg?Lys?Ile?Gly?Ala?Glu?Arg?Gly?Trp?Ala?Pro?Ala?Asp?Ala?Met?Gln

265 270 275

ttt?gaa?cgc?gaa?atc?gat?cac?ggt?tcc?tta?tac?atc?ggt?tcc?cct?gag 979

Phe?Glu?Arg?Glu?Ile?Asp?His?Gly?Ser?Leu?Tyr?Ile?Gly?Ser?Pro?Glu

280 285 290

acg?gtc?gca?aag?aag?atc?gcc?aaa?acc?att?tca?gtg?ctt?gat?ctt?gat 1027

Thr?Val?Ala?Lys?Lys?Ile?Ala?Lys?Thr?Ile?Ser?Val?Leu?Asp?Leu?Asp

295 300 305

cgc?ttt?acc?ctc?aaa?tac?gcc?agt?ggc?cag?acc?cct?cat?gag?tac?ttg 1075

Arg?Phe?Thr?Leu?Lys?Tyr?Ala?Ser?Gly?Gln?Thr?Pro?His?Glu?Tyr?Leu

310 315 320 325

ctg?aag?tcc?att?gag?ttg?tat?ggc?act?gag?gtt?att?ccg?ctg?gtg?aag 1123

Leu?Lys?Ser?Ile?Glu?Leu?Tyr?Gly?Thr?Glu?Val?Ile?Pro?Leu?Val?Lys

330 335 340

gac?atc?ttg?acc?aag?cag?gct?taagaaggtc?ttaggacatt?ccc 1167

Asp?Ile?Leu?Thr?Lys?Gln?Ala

345

<210>436

<211>348

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>436

Met?Lys?Asn?Val?Ser?Phe?Gly?Leu?Asp?Thr?Phe?Gly?Asp?Asn?Ala?Ile

1 5 10 15

Asp?Leu?Gln?Gly?Asn?Pro?Val?Ser?Pro?Ala?Gln?Thr?Leu?Arg?Asn?Ile

20 25 30

Ile?Asp?Glu?Ala?Lys?Met?Ala?Asp?Lys?Val?Gly?Val?Asp?Ile?Ile?Gly

35 40 45

Ile?Gly?Glu?His?His?Arg?Glu?Glu?Tyr?Ser?Val?Ser?Ala?Pro?Asp?Ile

50 55 60

Val?Met?Thr?Ala?Ile?Leu?Ala?Ser?Thr?Glu?Arg?Leu?Lys?Val?Thr?Ser

65 70 75 80

Ser?Val?Thr?Val?Leu?Ser?Ser?Asp?Asp?Pro?Val?Arg?Leu?Phe?Glu?Arg

85 90 95

Tyr?Ser?Thr?Met?Asn?Ala?Leu?Ser?Asn?Gly?Arg?Ala?Glu?Ile?Thr?Leu

100 105 110

Gly?Arg?Gly?Ser?Phe?Ile?Glu?Ser?Phe?Pro?Leu?Phe?Gly?Phe?Asp?Leu

115 120 125

Gln?Asp?Tyr?Glu?Gln?Leu?Phe?Ser?Glu?Arg?Leu?Asp?Leu?Phe?Ala?Lys

130 135 140

Ile?Leu?Glu?Ala?Asp?Ser?Arg?Gly?Gln?Gly?Val?Thr?Trp?His?Gly?Glu

145 150 155 160

Thr?Arg?Ser?Ala?Leu?Glu?Asn?Gln?Met?Leu?Tyr?Pro?Pro?Thr?Glu?Asn

165 170 175

Gly?Ile?His?Ala?Trp?Val?Ala?Val?Gly?Gly?Ser?Pro?Glu?Ser?Val?Val

180 185 190

Arg?Ala?Ala?Lys?Tyr?Arg?Phe?Pro?Leu?Met?Leu?Ala?Ile?Ile?Gly?Gly

195 200 205

Ala?Pro?Glu?Arg?Phe?Arg?Pro?Tyr?Val?Asp?Leu?Tyr?Lys?Arg?Ala?Asn

210 215 220

Glu?Gln?Phe?Gly?Gln?Pro?Gln?Lys?Pro?Ile?Gly?Val?His?Ser?Pro?Gly

225 230 235 240

Leu?Ile?Ala?Ala?Thr?Asp?Glu?Glu?Ala?Arg?Glu?Leu?Ala?Leu?Asn?Asp

245 250 255

Trp?Leu?Glu?Leu?Gln?Arg?Lys?Ile?Gly?Ala?Glu?Arg?Gly?Trp?Ala?Pro

260 265 270

Ala?Asp?Ala?Met?Gln?Phe?Glu?Arg?Glu?Ile?Asp?His?Gly?Ser?Leu?Tyr

275 280 285

Ile?Gly?Ser?Pro?Glu?Thr?Val?Ala?Lys?Lys?Ile?Ala?Lys?Thr?Ile?Ser

290 295 300

Val?Leu?Asp?Leu?Asp?Arg?Phe?Thr?Leu?Lys?Tyr?Ala?Ser?Gly?Gln?Thr

305 310 315 320

Pro?His?Glu?Tyr?Leu?Leu?Lys?Ser?Ile?Glu?Leu?Tyr?Gly?Thr?Glu?Val

325 330 335

Ile?Pro?Leu?Val?Lys?Asp?Ile?Leu?Thr?Lys?Gln?Ala

340 345

<210>437

<211>726

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(703)

<223>RXA01933

<400>437

ctagaagcct?taggcaagaa?atttggttga?gttttcgatc?tctacgacgc?gtcatctcaa?60

ttccacctag?gcttggatgc?aggttagaaa?ggagccttcg?atg?tct?aag?act?cgt 115

Met?Ser?Lys?Thr?Arg

1 5

act?ttt?ctg?ttt?gat?ctt?tat?ggt?gtt?ctc?atc?aag?gag?cat?ggt?gcg 163

Thr?Phe?Leu?Phe?Asp?Leu?Tyr?Gly?Val?Leu?Ile?Lys?Glu?His?Gly?Ala

10 15 20

gcg?cag?ttt?gag?cgg?gtt?gcg?cgt?gcg?gtg?ggg?gag?ccg?tcc?aag?aac 211

Ala?Gln?Phe?Glu?Arg?Val?Ala?Arg?Ala?Val?Gly?Glu?Pro?Ser?Lys?Asn

25 30 35

gac?aag?ctg?cat?gag?gtt?tat?gag?tcg?ctt?cgt?ctg?gat?ctg?gat?gcc 259

Asp?Lys?Leu?His?Glu?Val?Tyr?Glu?Ser?Leu?Arg?Leu?Asp?Leu?Asp?Ala

40 45 50

ggc?cgc?gtg?agt?gag?gtg?aat?tat?tgg?aat?cag?atc?aaa?cta?ttg?gtg 307

Gly?Arg?Val?Ser?Glu?Val?Asn?Tyr?Trp?Asn?Gln?Ile?Lys?Leu?Leu?Val

55 60 65

ggt?ttg?gag?ttt?ttg?gat?atc?cag?gag?gtc?atc?gcg?gct?gac?tac?agg 355

Gly?Leu?Glu?Phe?Leu?Asp?Ile?Gln?Glu?Val?Ile?Ala?Ala?Asp?Tyr?Arg

70 75 80 85

ggc?ctt?tat?gag?cgt?gat?cag?gac?atg?gtt?gat?tat?gtg?ttg?tcg?ttg 403

Gly?Leu?Tyr?Glu?Arg?Asp?Gln?Asp?Met?Val?Asp?Tyr?Val?Leu?Ser?Leu

90 95 100

aag?gcg?aaa?ggc?cac?cgc?atc?gga?att?ttg?tcg?aat?att?ccg?gag?ggg 451

Lys?Ala?Lys?Gly?His?Arg?Ile?Gly?Ile?Leu?Ser?Asn?Ile?Pro?Glu?Gly

105 110 115

ttg?gcc?aag?ctg?ttg?aag?gag?cac?aat?tcg?gag?tgg?ctt?gat?cag?ctt 499

Leu?Ala?Lys?Leu?Leu?Lys?Glu?His?Asn?Ser?Glu?Trp?Leu?Asp?Gln?Leu

120 125 130

gat?gcg?gtg?act?ttg?tcg?tgc?gat?att?ggc?gcg?gcg?aag?ccg?gag?ccg 547

Asp?Ala?Val?Thr?Leu?Ser?Cys?Asp?Ile?Gly?Ala?Ala?Lys?Pro?Glu?Pro

135 140 145

aag?tct?ttc?cat?gtg?gca?ctt?gag?gcc?ctt?ggt?gaa?aaa?gct?gag?gat 595

Lys?Ser?Phe?His?Val?Ala?Leu?Glu?Ala?Leu?Gly?Glu?Lys?Ala?Glu?Asp

150 155 160 165

gtg?acc?ttt?att?gat?gat?cgc?gtg?cgt?aac?att?gag?gca?gcg?cgc?gaa 643

Val?Thr?Phe?Ile?Asp?Asp?Arg?Val?Arg?Asn?Ile?Glu?Ala?Ala?Arg?Glu

170 175 180

gaa?ggt?ctc?agc?aca?att?cac?ttc?act?ggc?tta?gat?tcc?tta?aaa?gaa 691

Glu?Gly?Leu?Ser?Thr?Ile?His?Phe?Thr?Gly?Leu?Asp?Ser?Leu?Lys?Glu

185 190 195

agc?att?cag?gaa?tgacacctca?accactgatt?ttg 726

Ser?Ile?Gln?Glu

200

<210>438

<211>201

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>438

Met?Ser?Lys?Thr?Arg?Thr?Phe?Leu?Phe?Asp?Leu?Tyr?Gly?Val?Leu?Ile

1 5 10 15

Lys?Glu?His?Gly?Ala?Ala?Gln?Phe?Glu?Arg?Val?Ala?Arg?Ala?Val?Gly

20 25 30

Glu?Pro?Ser?Lys?Asn?Asp?Lys?Leu?His?Glu?Val?Tyr?Glu?Ser?Leu?Arg

35 40 45

Leu?Asp?Leu?Asp?Ala?Gly?Arg?Val?Ser?Glu?Val?Asn?Tyr?Trp?Asn?Gln

50 55 60

Ile?Lys?Leu?Leu?Val?Gly?Leu?Glu?Phe?Leu?Asp?Ile?Gln?Glu?Val?Ile

65 70 75 80

Ala?Ala?Asp?Tyr?Arg?Gly?Leu?Tyr?Glu?Arg?Asp?Gln?Asp?Met?Val?Asp

85 90 95

Tyr?Val?Leu?Ser?Leu?Lys?Ala?Lys?Gly?His?Arg?Ile?Gly?Ile?Leu?Ser

100 105 110

Asn?Ile?Pro?Glu?Gly?Leu?Ala?Lys?Leu?Leu?Lys?Glu?His?Asn?Ser?Glu

115 120 125

Trp?Leu?Asp?Gln?Leu?Asp?Ala?Val?Thr?Leu?Ser?Cys?Asp?Ile?Gly?Ala

130 135 140

Ala?Lys?Pro?Glu?Pro?Lys?Ser?Phe?His?Val?Ala?Leu?Glu?Ala?Leu?Gly

145 150 155 160

Glu?Lys?Ala?Glu?Asp?Val?Thr?Phe?Ile?Asp?Asp?Arg?Val?Arg?Asn?Ile

165 170 175

Glu?Ala?Ala?Arg?Glu?Glu?Gly?Leu?Ser?Thr?Ile?His?Phe?Thr?Gly?Leu

180 185 190

Asp?Ser?Leu?Lys?Glu?Ser?Ile?Gln?Glu

195 200

<2l0>439

<211>1039

<2l2>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(1039)

<223>RXA02351

<400>439

tgacacttta?cagactggtt?ttcaactaat?gacaccgaaa?gaaatacacc?tcaacctttt?60

tgctttcggt?gccgggcacc?acgcggcggc?gtggcgagcg?gtg?gag?gga?agc?gtc 115

Val?Glu?Gly?Ser?Val

1 5

gaa?aag?ctg?ggt?tta?att?tcc?tgg?tgg?gag?gaa?ctc?gcg?cgc?acc?gct 163

Glu?Lys?Leu?Gly?Leu?Ile?Ser?Trp?Trp?Glu?Glu?Leu?Ala?Arg?Thr?Ala

10 15 20

gag?cgg?ggc?aag?ctg?gat?gcg?gtc?ttt?ttg?gcc?gat?ggg?cag?gcg?att 211

Glu?Arg?Gly?Lys?Leu?Asp?Ala?Val?Phe?Leu?Ala?Asp?Gly?Gln?Ala?Ile

25 30 35

aat?ccg?gtc?ggt?ctg?gag?aat?ggg?ccg?ggc?tgg?ttt?ttg?gag?ccg?gtg 259

Asn?Pro?Val?Gly?Leu?Glu?Asn?Gly?Pro?Gly?Trp?Phe?Leu?Glu?Pro?Val

40 45 50

acc?gcg?ttg?act?gcg?atg?gcg?cgg?gcg?acg?aac?aat?att?ggg?ttg?atc 307

Thr?Ala?Leu?Thr?Ala?Met?Ala?Arg?Ala?Thr?Asn?Asn?Ile?Gly?Leu?Ile

55 60 65

agc?aca?att?tcc?agt?acg?ttt?tgg?cag?ccg?ttt?cat?gcg?gcg?cgg?atg 355

Ser?Thr?Ile?Ser?Ser?Thr?Phe?Trp?Gln?Pro?Phe?His?Ala?Ala?Arg?Met

70 75 80 85

atc?gcc?agc?ttg?gat?cat?att?tcg?ggt?ggg?cgt?gct?gga?atc?aat?gtg 403

Ile?Ala?Ser?Leu?Asp?His?Ile?Ser?Gly?Gly?Arg?Ala?Gly?Ile?Asn?Val

90 95 100

gtg?aca?tcg?atg?acc?gat?gcg?gag?gcg?cgt?aac?cac?ggg?atg?gat?gcg 451

Val?Thr?Ser?Met?Thr?Asp?Ala?Glu?Ala?Arg?Asn?His?Gly?Met?Asp?Ala

105 110 115

ttg?ccg?ggt?cac?gat?gtt?cgc?tat?gcg?cgc?gct?gcg?gaa?ttt?att?gaa 499

Leu?Pro?Gly?His?Asp?Val?Arg?Tyr?Ala?Arg?Ala?Ala?Glu?Phe?Ile?Glu

120 125 130

acc?atc?act?gcg?ctg?tgg?gat?tct?tgg?cct?gcg?gaa?agt?ttg?gtg?atg 547

Thr?Ile?Thr?Ala?Leu?Trp?Asp?Ser?Trp?Pro?Ala?Glu?Ser?Leu?Val?Met

135 140 145

gat?cgt?gct?gga?aaa?ttt?gcg?gac?tcc?tcg?ctc?att?aaa?tct?atc?gat 595

Asp?Arg?Ala?Gly?Lys?Phe?Ala?Asp?Ser?Ser?Leu?Ile?Lys?Ser?Ile?Asp

150 155 160 165

cat?gat?ggt?gag?ttc?ttc?caa?gtc?gct?ggt?ccg?ctg?aat?atc?ccc?agt 643

His?Asp?Gly?Glu?Phe?Phe?Gln?Val?Ala?Gly?Pro?Leu?Asn?Ile?Pro?Ser

170 175 180

cct?ccg?cag?ggt?cga?ccc?gta?ctt?ttt?cag?gct?gga?tcc?tca?ccg?caa 691

Pro?Pro?Gln?Gly?Arg?Pro?Val?Leu?Phe?Gln?Ala?Gly?Ser?Ser?Pro?Gln

185 190 195

gga?cgg?gaa?atc?gct?gcg?aaa?tac?gcc?gag?gca?att?tac?tct?gtg?gcg 739

Gly?Arg?Glu?Ile?Ala?Ala?Lys?Tyr?Ala?Glu?Ala?Ile?Tyr?Ser?Val?Ala

200 205 210

tgg?gat?ttg?gag?caa?gcg?caa?gat?tat?cgc?tct?gat?att?cat?gct?cgt 787

Trp?Asp?Leu?Glu?Gln?Ala?Gln?Asp?Tyr?Arg?Ser?Asp?Ile?His?Ala?Arg

215 220 225

gcc?act?gcc?cag?ggt?cgc?gag?ccc?atg?ccg?gtg?ctt?cct?ggt?ttg?gtg 835

Ala?Thr?Ala?Gln?Gly?Arg?Glu?Pro?Met?Pro?Val?Leu?Pro?Gly?Leu?Val

230 235 240 245

act?ttt?gtt?ggc?acg?acc?gtg?gaa?gaa?gcg?cgt?gca?aaa?cag?cag?gct 883

Thr?Phe?Val?Gly?Thr?Thr?Val?Glu?Glu?Ala?Arg?Ala?Lys?Gln?Gln?Ala

250 255 260

ctt?aat?gcg?ttg?ctg?ccg?gtc?aaa?gac?tca?cta?aat?cag?ttg?agt?ttc 931

Leu?Asn?Ala?Leu?Leu?Pro?Val?Lys?Asp?Ser?Leu?Asn?Gln?Leu?Ser?Phe

265 270 275

ttt?gtg?ggt?caa?gat?tgc?tcg?acg?tgg?gat?ttg?gat?gca?cct?ccc?cca 979

Phe?Val?Gly?Gln?Asp?Cys?Ser?Thr?Trp?Asp?Leu?Asp?Ala?Pro?Pro?Pro

280 285 290

cca?ctg?cca?ccg?cta?gaa?gag?ttt?tcc?ggt?cct?aaa?ggc?agg?tac?gaa 1027

Pro?Leu?Pro?Pro?Leu?Glu?Glu?Phe?Ser?Gly?Pro?Lys?Gly?Arg?Tyr?Glu

295 300 305

acg?gtc?ctg?cgg 1039

Thr?Val?Leu?Arg

310

<210>440

<211>313

<212>PRT

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<400>440

Val?Glu?Gly?Ser?Val?Glu?Lys?Leu?Gly?Leu?Ile?Ser?Trp?Trp?Glu?Glu

1 5 10 15

Leu?Ala?Arg?Thr?Ala?Glu?Arg?Gly?Lys?Leu?Asp?Ala?Val?Phe?Leu?Ala

20 25 30

Asp?Gly?Gln?Ala?Ile?Asn?Pro?Val?Gly?Leu?Glu?Asn?Gly?Pro?Gly?Trp

35 40 45

Phe?Leu?Glu?Pro?Val?Thr?Ala?Leu?Thr?Ala?Met?Ala?Arg?Ala?Thr?Asn

50 55 60

Asn?Ile?Gly?Leu?Ile?Ser?Thr?Ile?Ser?Ser?Thr?Phe?Trp?Gln?Pro?Phe

65 70 75 80

His?Ala?Ala?Arg?Met?Ile?Ala?Ser?Leu?Asp?His?Ile?Ser?Gly?Gly?Arg

85 90 95

Ala?Gly?Ile?Asn?Val?Val?Thr?Ser?Met?Thr?Asp?Ala?Glu?Ala?Arg?Asn

100 105 110

His?Gly?Met?Asp?Ala?Leu?Pro?Gly?His?Asp?Val?Arg?Tyr?Ala?Arg?Ala

115 120 125

Ala?Glu?Phe?Ile?Glu?Thr?Ile?Thr?Ala?Leu?Trp?Asp?Ser?Trp?Pro?Ala

130 135 140

Glu?Ser?Leu?Val?Met?Asp?Arg?Ala?Gly?Lys?Phe?Ala?Asp?Ser?Ser?Leu

145 150 155 160

Ile?Lys?Ser?Ile?Asp?His?Asp?Gly?Glu?Phe?Phe?Gln?Val?Ala?Gly?Pro

165 170 175

Leu?Asn?Ile?Pro?Ser?Pro?Pro?Gln?Gly?Arg?Pro?Val?Leu?Phe?Gln?Ala

180 185 190

Gly?Ser?Ser?Pro?Gln?Gly?Arg?Glu?Ile?Ala?Ala?Lys?Tyr?Ala?Glu?Ala

195 200 205

Ile?Tyr?Ser?Val?Ala?Trp?Asp?Leu?Glu?Gln?Ala?Gln?Asp?Tyr?Arg?Ser

210 215 220

Asp?Ile?His?Ala?Arg?Ala?Thr?Ala?Gln?Gly?Arg?Glu?Pro?Met?Pro?Val

225 230 235 240

Leu?Pro?Gly?Leu?Val?Thr?Phe?Val?Gly?Thr?Thr?Val?Glu?Glu?Ala?Arg

245 250 255

Ala?Lys?Gln?Gln?Ala?Leu?Asn?Ala?Leu?Leu?Pro?Val?Lys?Asp?Ser?Leu

260 265 270

Asn?Gln?Leu?Ser?Phe?Phe?Val?Gly?Gln?Asp?Cys?Ser?Thr?Trp?Asp?Leu

275 280 285

Asp?Ala?Pro?Pro?Pro?Pro?Leu?Pro?Pro?Leu?Glu?Glu?Phe?Ser?Gly?Pro

290 295 300

Lys?Gly?Arg?Tyr?Glu?Thr?Val?Leu?Arg

305 310

<210>441

<211>18

<212>DNA

＜213〉artificial sequence

<220>

＜223〉description of artificial sequence: primer

<400>441

ggaaacagta?tgaccatg 18

<210>442

<211>17

<212>DNA

＜213〉artificial sequence

<220>

＜223〉description of artificial sequence: primer

<400>442

gtaaaacgac?ggccagt 17

Claims (33)

1. nucleic acid molecule or its complementary molecule of an isolating Corynebacterium glutamicum (Corynebacterium glutamicum), described nucleic acid molecule comprises the nucleotide sequence of each odd-numbered that is selected from SEQ ID NO:3 to 439, and prerequisite is that described nucleic acid molecule be can't help the genomic constitution of any F sign that table 1 provides.

2. an isolated nucleic acid molecule or its complementary molecule, described nucleic acid molecule encoding comprises the polypeptide of one section aminoacid sequence, described aminoacid sequence is selected from the aminoacid sequence of each even-numbered of SEQ ID NO:4 to 440, and prerequisite is that described nucleic acid molecule be can't help the genomic constitution of any F sign that table 1 provides.

3. an isolated nucleic acid molecule or its complementary molecule, the naturally occurring allelic variation body of described nucleic acid molecule encoding one peptide species, described polypeptide comprises the aminoacid sequence of each even-numbered that is selected from SEQ ID NO:4 to 440, and prerequisite is that described nucleic acid molecule be can't help the genomic constitution of any F sign that table 1 provides.

4. an isolated nucleic acid molecule or its complementary molecule, the complete nucleotide sequence of arbitrary odd-numbered of itself and SEQ ID NO:3 to 439 has at least 50% homology, and prerequisite is that described nucleic acid molecule be can't help the genomic constitution of any F sign that table 1 provides.

5. an isolated nucleic acid molecule or its complementary molecule, described nucleic acid molecule comprises the fragment of at least 15 continuous nucleotides of nucleotide sequence of arbitrary odd-numbered of SEQID NO:3 to 439, and prerequisite is that described nucleic acid molecule be can't help the genomic constitution of any F sign that table 1 provides.

6. isolated nucleic acid molecule, described nucleic acid molecule comprise each nucleic acid molecule and the nucleotide sequence of coding heterologous polypeptide among the claim 1-5.

7. carrier, described carrier comprise among the claim 1-6 each nucleic acid molecule.

8. the carrier of claim 7, described carrier is an expression vector.

9. host cell, described host cell are the host cells with the expression vector transfection of claim 8.

10. the host cell of claim 9, wherein said cell is a microorganism.

11. the host cell of claim 10, wherein said cell belong to Corynebacterium (Corynebacterium) or brevibacterium sp (Brevibacterium).

12. the host cell of claim 9, the expression of wherein said nucleic acid molecule cause regulating producing fine chemicals by described cell.

13. the host cell of claim 12, wherein said fine chemicals is selected from: organic acid, the proteinic amino acid of generation and the proteinic amino acid of non-generation, purine and pyrimidine bases, nucleosides, Nucleotide, lipid, saturated and unsaturated fatty acids, dibasic alcohol, carbohydrate, aromatic substance, VITAMIN, cofactor, polyketide and enzyme.

14. a method of producing polypeptide, this method are included in the host cell of cultivating claim 9 in the suitable culture medium, produce described polypeptide thus.

15. an isolated polypeptide, it comprises the aminoacid sequence of each even-numbered that is selected from SEQ ID NO:4 to 440, and prerequisite is that described aminoacid sequence be can't help the genes encoding of any F sign that table 1 provides.

16. isolated polypeptide, described polypeptide comprises the naturally occurring allelic variation body of the polypeptide of the aminoacid sequence that contains each even-numbered that is selected from SEQ ID NO:4 to 440, and prerequisite is that described aminoacid sequence be can't help the genes encoding of any F sign that table 1 provides.

17. isolated polypeptide, described polypeptide is by a kind of nucleic acid molecule encoding, described nucleic acid molecule comprises the nucleotide sequence that the complete nucleotide sequence with arbitrary odd-numbered of SEQ ID NO:3 to 439 has at least 50% homology, and prerequisite is that described nucleic acid molecule be can't help the nucleic acid molecule of any F sign that table 1 provides and formed.

18. isolated polypeptide, described polypeptide comprises the aminoacid sequence that has 50% homology with the complete amino acid sequence of arbitrary even-numbered of SEQ ID NO:4 to 440 at least, and prerequisite is that described aminoacid sequence be can't help the genes encoding of any F sign that table 1 provides.

19. isolated polypeptide, it comprises the fragment of polypeptide of the aminoacid sequence of the arbitrary even-numbered that contains SEQ ID NO:4 to 440, prerequisite is that described aminoacid sequence be can't help the genes encoding of any F sign that table 1 provides, and wherein said polypeptide fragment has kept the biological activity of the polypeptide that comprises described aminoacid sequence.

20. each isolated polypeptide among the claim 15-19, it further comprises the allogeneic amino acid sequence.

21. a method of producing fine chemicals, described method comprises the cell of cultivating claim 9, produces described fine chemicals thus.

22. the method for claim 21, wherein said method also comprises the step that reclaims described fine chemicals from described culture.

23. the method for claim 21, wherein said cell belongs to Corynebacterium or brevibacterium sp.

24. the method for claim 21, wherein said cell is selected from: Corynebacterium glutamicum (Corynebacterium glutamicum), man of great strength's rod bacillus (Corynebacteriumherculis), lily hedysarum scoparium bacillus (Corynebacterium lilium), Corynebacterium acctoacidophlum (Corynebacterium acetoacidophilum), vinegar paddy rod bacillus (Corynebacteriumacetoglutamicum), have a liking for acetyl rod bacillus (Corynebacterium acetophilum), produce ammonia rod bacillus (Corynebacterium ammomagenes), Corynebacteriumfujiokense, Corynebacterium nitrilophilus, Brevibacterium ammoniagenes (Brevibacteriumammoniagenes), Brevibacterium butanicum, Corynebacterium glutamicum (Brevibacterium divaricatum), brevibacterium flavum (Brevibacterium flavum), Xi Shi tyrothricin (Brevibacterium healii), ketoisocaproic tyrothricin (Brevibacteriumketoglutamicum), Brevibacterium ketosoreductum, brevibacterium (Brevibacterium lactofermentum), extension brevibacterium (Brevibacterium linens), the bacterial strain that provides in Brevibacterium paraffinolyticum and the table 3.

25. the method for claim 21 wherein causes production to described fine chemicals to produce from the expression of the described nucleic acid molecule of described carrier and regulates.

26. the method for claim 21, wherein said fine chemicals is selected from: organic acid, the proteinic amino acid of generation and the proteinic amino acid of non-generation, purine and pyrimidine bases, nucleosides, Nucleotide, lipid, saturated and unsaturated fatty acids, dibasic alcohol, carbohydrate, aromatic substance, VITAMIN, cofactor, polyketide and enzyme.

27. the method for claim 21, wherein said fine chemicals are amino acid.

28. the method for claim 27, wherein said amino acid is selected from: Methionin, L-glutamic acid, glutamine, L-Ala, aspartic acid, glycine, Serine, Threonine, methionine(Met), halfcystine, Xie Ansuan, leucine, Isoleucine, arginine, proline(Pro), Histidine, tyrosine, phenylalanine and tryptophane.

29. a method of producing fine chemicals, described method comprise the cell of cultivating its genomic dna and changing because containing among the claim 1-6 each nucleic acid molecule.

30. existence or its active method of diagnosing corynebacterium diphtheriae in curee's body, described method comprises the nucleotide sequence that whether has at least a claim 1 to 5 in the described curee's body of detection, or the peptide molecule of claim 15-19, diagnose the existence or the activity of corynebacterium diphtheriae in described curee's body thus.

31. a host cell, described host cell comprise the nucleic acid molecule of each odd-numbered that is selected from SEQ ID NO:3 to 439, wherein said nucleic acid molecule is destroyed.

32. host cell, described host cell comprises the nucleic acid molecule of each odd-numbered that is selected from SEQ ID NO:3 to 439, wherein compare, comprise one or more nucleic acid in the described nucleic acid molecule and modify with the sequence of arbitrary odd-numbered of SEQ ID NO:3 to 439.

33. a host cell, described host cell comprise the nucleotide sequence of each odd-numbered that is selected from SEQ ID NO:3 to 439, wherein for the wild-type regulatory region of described nucleic acid molecule, the regulatory region of described nucleic acid molecule is modified.