CN1742966A - Fuyanling preparation for treating gynaecologic inflammationa nd preparing method - Google Patents
Fuyanling preparation for treating gynaecologic inflammationa nd preparing method Download PDFInfo
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- CN1742966A CN1742966A CN 200410046735 CN200410046735A CN1742966A CN 1742966 A CN1742966 A CN 1742966A CN 200410046735 CN200410046735 CN 200410046735 CN 200410046735 A CN200410046735 A CN 200410046735A CN 1742966 A CN1742966 A CN 1742966A
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- fuyanling
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- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims description 26
- 239000003826 tablet Substances 0.000 claims abstract description 21
- 239000000829 suppository Substances 0.000 claims abstract description 19
- 239000002775 capsule Substances 0.000 claims abstract description 7
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims description 66
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 24
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 22
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 22
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 20
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 20
- 239000004327 boric acid Substances 0.000 claims description 20
- 229940025250 camphora Drugs 0.000 claims description 20
- 239000010238 camphora Substances 0.000 claims description 20
- -1 common bolt Substances 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 16
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000000576 coating method Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 238000010992 reflux Methods 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 6
- 239000007901 soft capsule Substances 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 239000002674 ointment Substances 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- 229920003081 Povidone K 30 Polymers 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 235000010445 lecithin Nutrition 0.000 claims description 3
- 239000000787 lecithin Substances 0.000 claims description 3
- 229940067606 lecithin Drugs 0.000 claims description 3
- 229940057995 liquid paraffin Drugs 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 229940099259 vaseline Drugs 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 2
- 239000010408 film Substances 0.000 claims description 2
- 239000008394 flocculating agent Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- 238000005457 optimization Methods 0.000 claims description 2
- 238000005325 percolation Methods 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 238000004062 sedimentation Methods 0.000 claims description 2
- 210000000582 semen Anatomy 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000010409 thin film Substances 0.000 claims description 2
- 238000001291 vacuum drying Methods 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 239000007884 disintegrant Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 13
- 239000000706 filtrate Substances 0.000 description 13
- 238000003756 stirring Methods 0.000 description 13
- 229960004756 ethanol Drugs 0.000 description 11
- 239000006071 cream Substances 0.000 description 10
- 239000000796 flavoring agent Substances 0.000 description 10
- 235000019634 flavors Nutrition 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 238000011049 filling Methods 0.000 description 8
- 238000012856 packing Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 238000004064 recycling Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001746 injection moulding Methods 0.000 description 3
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229960000935 dehydrated alcohol Drugs 0.000 description 2
- 239000007919 dispersible tablet Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 1
- 208000001387 Causalgia Diseases 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a Fuyanling preparation and its preparation process. On the basis of existent Fuyanling capsule and effervescent tablet said invention adopts the modern pharmaceutical technology to develop the invented series Fuyanling preparation products, such as guick disintegrant tablet and suppository, etc.
Description
Technical field
The present invention relates to a kind of Chinese medicine, specifically FUYANLING preparation and preparation method thereof.
Background technology
The FUYANLING preparation of forming by Folium Callicarpae Formosanae, Herba Agrimoniae, Fructus Cnidii, Radix Sophorae Flavescentis, the Radix Stemonae, boric acid, Alumen, Camphora, Borneolum Syntheticum, benzalkonium bromide ten flavors, function with heat clearing and damp drying, killing parasites for relieving itching, be used for pudendal pruritus that damp invasion of lower energizer causes, causalgia, leucorrhea with red and white discharge or doublely see diseases such as frequent micturition, urgent micturition, dysurea, and mycotic, infusorian property, bacterial vaginitis see that above-mentioned patient has significant curative effect.FUYANLING JIAONANG (recording for the 17 of the Sanitation Ministry medicine standard " Chinese traditional patent formulation preparation ") and FUYANLING effervescent tablet (new Chinese medicine) are arranged at present.The hard capsule softgel shell dissolves slowly; Though effervescent tablet has curative effect preferably because foamy generation can increase contacting of medicine and agents area, owing to include the soda acid effervescent, use often inflammation mucosa generation zest, influence its Clinical Application.
Summary of the invention
The objective of the invention is to provide a kind of scalable, good effect that has, the FUYANLING preparation of nonirritant, compliance advantages of higher further satisfies and ensures the medication demand of vast female patient.
Purpose of the present invention can take following method to realize:
The FUYANLING preparation is characterized in that it is that component is formed or made other various preparations except that capsule, effervescent tablet that active component and pharmaceutically acceptable additives are formed by the extract of following main materials by following main materials, as ordinary tablet, fast disintegrating tablet, dispersible tablet, common bolt, soft capsule suppository, type of effervescent suppository, gel, membrane, ointment etc.
Folium Callicarpae Formosanae 50-500 weight portion, Herba Agrimoniae 50-500 weight portion, Fructus Cnidii 50-500 weight portion, Radix Sophorae Flavescentis 50-500 weight portion, Radix Stemonae 50-500 weight portion, boric acid 30-300 weight portion, Alumen 5-50 weight portion, Camphora 5-50 weight portion, Borneolum Syntheticum 2-20 weight portion, benzalkonium bromide 3-30 weight portion.
Formula optimization is:
Folium Callicarpae Formosanae 100 weight portions, Herba Agrimoniae 100 weight portions, Fructus Cnidii 100 weight portions, Radix Sophorae Flavescentis 100 weight portions, the Radix Stemonae 100 weight portions, boric acid 60 weight portions, Alumen 10 weight portions, Camphora 10 weight portions, Borneolum Syntheticum 5 weight portions, benzalkonium bromide 6 weight portions.
Described pharmaceutically acceptable additives are following one or more:
Dextrin, starch, methylcellulose, pregelatinized Starch, sodium alginate, magnesium stearate, 30 POVIDONE K 30 BP/USP
30, microcrystalline Cellulose, carboxymethylstach sodium, micropowder silica gel, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carboxymethylcellulose calcium, ethylparaben, carbomer, vaseline, liquid Paraffin, tween 80, lecithin, sodium lauryl sulphate, stearic acid, semi-synthetic fatty acid ester, glycerol, gelatin, Polyethylene Glycol, Oleum Sesami, soybean oil, Semen arachidis hypogaeae wet goods.
Described tablet can be risen other outer various suitable tablets of sheet for de-bubble, and as ordinary tablet, fast disintegrating tablet etc., available suitable coating material coating is coating not also.
Described suppository can be the suppository of ordinary suppository, capsule bolt, type of effervescent suppository or other type.
The preparation method of FUYANLING preparation is characterized in that it may further comprise the steps:
(1) in the prescription Radix Sophorae Flavescentis pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after medicinal residues again water carry or acid extraction or other suitable method are extracted;
(2) in the prescription Fructus Cnidii pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after the medicinal residues method that water is carried or other is suitable again extract;
(3) in the prescription Folium Callicarpae Formosanae, Herba Agrimoniae, the Radix Stemonae pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after the medicinal residues method that water is carried or other is suitable again extract;
(4) prescription mesoboric acid, Alumen pulverizing or superfine powder are broken into fine powder or other suitable method processing;
(5) Borneolum Syntheticum, Camphora pulverize separately or superfine powder are broken into fine powder or grind altogether or add or handle with other suitable method with The suitable solvent dissolving back in the prescription;
(6) benzalkonium bromide pulverizing or superfine powder are broken into fine powder or other suitable method processing in the prescription;
(7) be ground into fine powder in the step and be ground into 100-160 purpose fine powder usually, the best is broken into 200-300 purpose fine powder for superfine powder;
(8) condition of alcohol extraction is in the step: with 50-95% ethanol is solvent, can adopt heating reflux method or percolation or other suitable method to extract;
(9) condition that water is carried in the step is: decoct with water at 90-98 ℃ and extract each 1-3 hour 2-4 time;
(10) extracting gained water extract in the step can adopt precipitate with ethanol or add the flocculating agent sedimentation or method that other is suitable is further handled;
(11) concentrate, adopt concentrating under reduced pressure or thin film concentration or vacuum film to concentrate or other proper method;
(12) drying can adopt vacuum drying or spray drying or lyophilization or other suitable method;
(13) add different additives as required, adopt suitable moulding process, be prepared from other the various preparations except that capsule, effervescent tablet, as ordinary tablet, fast disintegrating tablet, dispersible tablet, common bolt, soft capsule suppository, type of effervescent suppository, gel, membrane, ointment etc.
The specific embodiment
Embodiment 1:
Get Folium Callicarpae Formosanae 100 grams, Herba Agrimoniae 100 grams, Fructus Cnidii 100 grams, Radix Sophorae Flavescentis 100 grams, the Radix Stemonae 100 grams, boric acid 60 grams, Alumen 10 grams, Camphora 10 grams, Borneolum Syntheticum 5 grams, benzalkonium bromide 6 grams.
Ten flavor medicines are up to the standards standby respectively in will filling a prescription; Getting Fructus Cnidii, to be ground into fine powder standby; Folium Callicarpae Formosanae, Radix Sophorae Flavescentis, the Radix Stemonae, Herba Agrimoniae decoct with water secondary, are 2 hours for the first time, are 1.5 hours for the second time, and collecting decoction filters, and filtrate is concentrated into the thick paste shape, adds Fructus Cnidii fine powder and benzalkonium bromide, stirs evenly, and drying is ground into fine powder, sieves; Boric acid, Alumen are ground into fine powder, with above-mentioned powder and appropriate amount of auxiliary materials mixing, alcohol granulation, drying, camphorate, Borneolum Syntheticum fine powder mixing, and tabletting, coating, packing promptly gets the FUYANLING sheet.
Embodiment 2:
Get Folium Callicarpae Formosanae 500 grams, Herba Agrimoniae 500 grams, Fructus Cnidii 500 grams, Radix Sophorae Flavescentis 500 grams, the Radix Stemonae 500 grams, boric acid 300 grams, Alumen 50 grams, Camphora 50 grams, Borneolum Syntheticum 20 grams, benzalkonium bromide 30 grams.
Ten flavor medicines are up to the standards standby respectively in will filling a prescription; Get Radix Sophorae Flavescentis, Fructus Cnidii is ground into coarse powder, extracts secondary with 85% alcohol heat reflux, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol is condensed into the thick paste shape, adds appropriate amount of starch and mixes 60 ℃ of dry for standby thoroughly; The medicinal residues of Folium Callicarpae Formosanae, the Radix Stemonae, Herba Agrimoniae and above-mentioned Radix Sophorae Flavescentis etc. decoct with water secondary, are 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated into the thick paste shape, add appropriate amount of starch and mix 80 ℃ of dry for standby thoroughly; Boric acid, Alumen are ground into fine powder, with above-mentioned powder and appropriate amount of auxiliary materials mixing, add 6% 30 POVIDONE K 30 BP/USP
30Alcoholic solution, mixing is granulated, drying camphorates, the ethanol solution of Borneolum Syntheticum, benzalkonium bromide, mix thoroughly, airtight 24 hours, tabletting, coating, packing promptly gets the FUYANLING sheet.
Embodiment 3:
Get Folium Callicarpae Formosanae 50 grams, Herba Agrimoniae 50 grams, Fructus Cnidii 50 grams, Radix Sophorae Flavescentis 50 grams, the Radix Stemonae 50 grams, boric acid 30 grams, Alumen 5 grams, Camphora 5 grams, Borneolum Syntheticum 2 grams, benzalkonium bromide 3 grams.
Ten flavor medicines are up to the standards standby respectively in will filling a prescription; Get Radix Sophorae Flavescentis, Fructus Cnidii is ground into coarse powder, extracts secondary with 85% alcohol heat reflux, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol is concentrated into standby in right amount; The medicinal residues of Folium Callicarpae Formosanae, the Radix Stemonae, Herba Agrimoniae and above-mentioned Radix Sophorae Flavescentis etc. decoct with water secondary, are 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated in right amount, stir evenly with above-mentioned concentrated solution, and spray drying, it is standby to collect dried cream powder; Boric acid, Alumen are ground into fine powder, and with above-mentioned dried cream powder and an amount of fast disintegrating tablet auxiliary materials and mixing, dehydrated alcohol is granulated, drying, camphorate, the ethanol solution of Borneolum Syntheticum, benzalkonium bromide, mix thoroughly, airtight 24 hours, tabletting, coating, packing promptly gets FUYANLING speed disintegrating tablet.
Embodiment 4:
Get Folium Callicarpae Formosanae 275 grams, Herba Agrimoniae 275 grams, Fructus Cnidii 275 grams, Radix Sophorae Flavescentis 275 grams, the Radix Stemonae 275 grams, boric acid 165 grams, Alumen 27.5 grams, Camphora 27.5 grams, Borneolum Syntheticum 11 grams, benzalkonium bromide 16.5 grams.
Ten flavor medicines are up to the standards standby respectively in will filling a prescription; The eight flavor medicated powder of getting in the prescription except that Camphora, Borneolum Syntheticum are broken into fine powder, and with an amount of fast disintegrating tablet auxiliary materials and mixing, dehydrated alcohol is granulated, and drying camphorates, the ethanol solution of Borneolum Syntheticum, mix thoroughly, and airtight 24 hours, tabletting, coating, packing promptly get the fast disintegrating tablet of FUYANLING.
Embodiment 5:
Get Folium Callicarpae Formosanae 100 grams, Herba Agrimoniae 100 grams, Fructus Cnidii 100 grams, Radix Sophorae Flavescentis 100 grams, the Radix Stemonae 100 grams, boric acid 60 grams, Alumen 10 grams, Camphora 10 grams, Borneolum Syntheticum 5 grams, benzalkonium bromide 6 grams.
Ten flavor medicines are up to the standards standby respectively in will filling a prescription; Get Radix Sophorae Flavescentis, Fructus Cnidii is ground into coarse powder, extracts secondary with 85% alcohol heat reflux, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol is concentrated into standby in right amount; The medicinal residues of Folium Callicarpae Formosanae, the Radix Stemonae, Herba Agrimoniae and above-mentioned Radix Sophorae Flavescentis etc. decoct with water secondary, are 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated in right amount, stir evenly with above-mentioned concentrated solution, and spray drying, it is standby to collect dried cream powder; Boric acid, Alumen, Camphora, Borneolum Syntheticum, benzalkonium bromide are ground into fine powder, with above-mentioned dried cream powder mixing, add liquid Paraffin and stir evenly standby in right amount; Other gets vaseline, lecithin is an amount of, and heat fused, temperature are reduced to about 50 ℃,, add above-mentioned spares, fully stir evenly, be pressed into soft capsule, packing promptly gets the FUYANLING soft capsule suppository.
Embodiment 6:
Get Folium Callicarpae Formosanae 100 grams, Herba Agrimoniae 50 grams, Fructus Cnidii 50 grams, Radix Sophorae Flavescentis 50 grams, the Radix Stemonae 50 grams, boric acid 30 grams, Alumen 5 grams, Camphora 5 grams, Borneolum Syntheticum 2 grams, benzalkonium bromide 3 grams.
Ten flavor medicines are up to the standards standby respectively in will filling a prescription; Get Radix Sophorae Flavescentis, Fructus Cnidii is ground into coarse powder, extracts secondary with 85% alcohol heat reflux, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol is concentrated into standby in right amount; The medicinal residues of Folium Callicarpae Formosanae, the Radix Stemonae, Herba Agrimoniae and above-mentioned Radix Sophorae Flavescentis etc. decoct with water secondary, are 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated in right amount, stir evenly with above-mentioned concentrated solution, and spray drying, it is standby to collect dried cream powder; Boric acid, Alumen, Camphora, Borneolum Syntheticum, benzalkonium bromide are ground into fine powder, and be standby with above-mentioned dried cream powder mixing; It is an amount of to get polyoxyethylene stearate (40) ester, Polyethylene Glycol-1500, Polyethylene Glycol-6000, when heat fused, temperature are reduced to 70 ℃, adding above-mentioned medicated powder, citric acid and an amount of tween 80 stirs evenly, temperature is reduced to about 50 ℃, adds sodium bicarbonate again and stirs evenly, and injection molding is made the FUYANLING type of effervescent suppository.
Embodiment 7:
Get Folium Callicarpae Formosanae 500 grams, Herba Agrimoniae 100 grams, Fructus Cnidii 100 grams, Radix Sophorae Flavescentis 100 grams, the Radix Stemonae 100 grams, boric acid 60 grams, Alumen 10 grams, Camphora 10 grams, Borneolum Syntheticum 5 grams, benzalkonium bromide 6 grams.
Ten flavor medicines are up to the standards standby respectively in will filling a prescription; Get Radix Sophorae Flavescentis, Fructus Cnidii is ground into coarse powder, extracts secondary with 85% alcohol heat reflux, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol is concentrated into standby in right amount; The medicinal residues of Folium Callicarpae Formosanae, the Radix Stemonae, Herba Agrimoniae and above-mentioned Radix Sophorae Flavescentis etc. decoct with water secondary, are 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated in right amount, stir evenly with above-mentioned concentrated solution, and drying under reduced pressure is pulverized, and it is standby to collect dried cream powder; Boric acid, Alumen, Camphora, Borneolum Syntheticum, benzalkonium bromide are ground into fine powder, and be standby with above-mentioned dried cream powder mixing; With the Myrj 45 heating and melting, after the anhydrous calcium chloride dehydration, filtering calcium chloride is standby; After getting the Myrj 45 heating and melting, under agitation add above-mentioned standby medicated powder respectively, fully stir evenly, injection molding, cooling, demoulding, packing promptly gets the FUYANLING bolt.
Embodiment 8:
Get Folium Callicarpae Formosanae 100 grams, Herba Agrimoniae 100 grams, Fructus Cnidii 100 grams, Radix Sophorae Flavescentis 100 grams, the Radix Stemonae 100 grams, boric acid 60 grams, Alumen 10 grams, Camphora 10 grams, Borneolum Syntheticum 5 grams, benzalkonium bromide 6 grams.
Ten flavor medicines are up to the standards standby respectively in will filling a prescription; Get Radix Sophorae Flavescentis, Fructus Cnidii is ground into coarse powder, extracts secondary with 85% alcohol heat reflux, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol is concentrated into standby in right amount; The medicinal residues of Folium Callicarpae Formosanae, the Radix Stemonae, Herba Agrimoniae and above-mentioned Radix Sophorae Flavescentis etc. decoct with water secondary, are 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated in right amount, stir evenly with above-mentioned concentrated solution, and spray drying, it is standby to collect dried cream powder; Boric acid, Alumen, Camphora, Borneolum Syntheticum, benzalkonium bromide are ground into fine powder, and be standby with above-mentioned dried cream powder mixing; Get lanoline, paraffin, semi-synthetic fatty acid glyceride (38 type) heat fused, stir evenly, temperature is reduced to about 50 ℃, adds above-mentioned medicated powder, fully stir evenly, and injection molding, cooling, demoulding, packing promptly gets the FUYANLING bolt.
Claims (6)
1, the FUYANLING preparation is characterized in that it is that component is formed or made other various preparations except that capsule, effervescent tablet that active component and pharmaceutically acceptable additives are formed by the extract of following main materials by following main materials, as ordinary tablet, fast disintegrating tablet, common bolt, soft capsule suppository, type of effervescent suppository, gel, membrane, ointment;
Folium Callicarpae Formosanae 50-500 weight portion, Herba Agrimoniae 50-500 weight portion, Fructus Cnidii 50-500 weight portion, Radix Sophorae Flavescentis 50-500 weight portion, Radix Stemonae 50-500 weight portion, boric acid 30-300 weight portion, Alumen 5-50 weight portion, Camphora 5-50 weight portion, Borneolum Syntheticum 2-20 weight portion, benzalkonium bromide 3-30 weight portion.
2, FUYANLING preparation according to claim 1 is characterized in that formula optimization is:
Folium Callicarpae Formosanae 100 weight portions, Herba Agrimoniae 100 weight portions, Fructus Cnidii 100 weight portions, Radix Sophorae Flavescentis 100 weight portions, the Radix Stemonae 100 weight portions, boric acid 60 weight portions, Alumen 10 weight portions, Camphora 10 weight portions, Borneolum Syntheticum 5 weight portions, benzalkonium bromide 6 weight portions.
3, FUYANLING preparation according to claim 1 is characterized in that described pharmaceutically acceptable additives are following one or more:
Dextrin, starch, methylcellulose, pregelatinized Starch, sodium alginate, magnesium stearate, 30 POVIDONE K 30 BP/USP 30, microcrystalline Cellulose, carboxymethylstach sodium, micropowder silica gel, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carboxymethylcellulose calcium, ethylparaben, carbomer, vaseline, liquid Paraffin, tween 80, lecithin, sodium lauryl sulphate, stearic acid, semi-synthetic fatty acid ester, glycerol, gelatin, Polyethylene Glycol, Oleum Sesami, soybean oil, Oleum Arachidis hypogaeae semen.
4, FUYANLING preparation according to claim 1 is characterized in that described tablet can rise other outer various suitable tablets of sheet for de-bubble, and as ordinary tablet, fast disintegrating tablet etc., available suitable coating material coating is coating not also.
5, FUYANLING preparation according to claim 1 is characterized in that described suppository can be the suppository of ordinary suppository, capsule bolt, type of effervescent suppository or other type.
6, the preparation method of FUYANLING preparation is characterized in that it may further comprise the steps:
(1) in the prescription Radix Sophorae Flavescentis pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after medicinal residues again water carry or acid extraction or other suitable method are extracted;
(2) in the prescription Fructus Cnidii pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after the medicinal residues method that water is carried or other is suitable again extract;
(3) in the prescription Folium Callicarpae Formosanae, Herba Agrimoniae, the Radix Stemonae pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after the medicinal residues method that water is carried or other is suitable again extract;
(4) prescription mesoboric acid, Alumen pulverizing or superfine powder are broken into fine powder or other suitable method processing;
(5) Borneolum Syntheticum, Camphora pulverize separately or superfine powder are broken into fine powder or grind altogether or add or handle with other suitable method with The suitable solvent dissolving back in the prescription;
(6) benzalkonium bromide pulverizing or superfine powder are broken into fine powder or other suitable method processing in the prescription;
(7) be ground into fine powder in the step and be ground into 100-160 purpose fine powder usually, the best is broken into 200-300 purpose fine powder for superfine powder;
(8) condition of alcohol extraction is in the step: with 50-95% ethanol is solvent, can adopt heating reflux method or percolation or other suitable method to extract;
(9) condition that water is carried in the step is: decoct with water at 90-98 ℃ and extract each 1-3 hour 2-4 time;
(10) extracting gained water extract in the step can adopt precipitate with ethanol or add the flocculating agent sedimentation or method that other is suitable is further handled;
(11) concentrate, adopt concentrating under reduced pressure or thin film concentration or vacuum film to concentrate or other proper method;
(12) drying can adopt vacuum drying or spray drying or lyophilization or other suitable method;
(13) add different additives as required, adopt suitable moulding process, be prepared from other the various preparations except that capsule, effervescent tablet, as ordinary tablet, fast disintegrating tablet, common bolt, soft capsule suppository, type of effervescent suppository, gel, membrane, ointment etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046735 CN1742966A (en) | 2004-09-05 | 2004-09-05 | Fuyanling preparation for treating gynaecologic inflammationa nd preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046735 CN1742966A (en) | 2004-09-05 | 2004-09-05 | Fuyanling preparation for treating gynaecologic inflammationa nd preparing method |
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| CN1742966A true CN1742966A (en) | 2006-03-08 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520603A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Fuyanling expandable vaginal suppository, and preparation method and detection method thereof |
| CN103520604A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Baicao expandable vaginal suppository for clearing gynecologic inflammation, and preparation method and detection method thereof |
| CN105169163A (en) * | 2015-10-20 | 2015-12-23 | 贵州长生药业有限责任公司 | Composite suppository and preparation method thereof |
| CN105169153A (en) * | 2015-08-27 | 2015-12-23 | 浙江苏泊尔南洋药业有限公司 | Dampness removing and parasite destroying traditional Chinese medicine composition and preparation method thereof |
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2004
- 2004-09-05 CN CN 200410046735 patent/CN1742966A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520603A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Fuyanling expandable vaginal suppository, and preparation method and detection method thereof |
| CN103520604A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Baicao expandable vaginal suppository for clearing gynecologic inflammation, and preparation method and detection method thereof |
| CN105169153A (en) * | 2015-08-27 | 2015-12-23 | 浙江苏泊尔南洋药业有限公司 | Dampness removing and parasite destroying traditional Chinese medicine composition and preparation method thereof |
| CN105169153B (en) * | 2015-08-27 | 2019-04-23 | 杭州苏泊尔南洋药业有限公司 | A kind of Chinese medicine composition of removing dampness and destroying parasites and preparation method thereof |
| CN105169163A (en) * | 2015-10-20 | 2015-12-23 | 贵州长生药业有限责任公司 | Composite suppository and preparation method thereof |
| CN105169163B (en) * | 2015-10-20 | 2019-02-22 | 贵州长生药业有限责任公司 | A kind of compound suppository and preparation method thereof |
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