CN1621062A - Chinese traditional medicinal injection for treating chronic hepatitis - Google Patents
Chinese traditional medicinal injection for treating chronic hepatitis Download PDFInfo
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- CN1621062A CN1621062A CN 200310107087 CN200310107087A CN1621062A CN 1621062 A CN1621062 A CN 1621062A CN 200310107087 CN200310107087 CN 200310107087 CN 200310107087 A CN200310107087 A CN 200310107087A CN 1621062 A CN1621062 A CN 1621062A
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- China
- Prior art keywords
- chronic
- chinese medicine
- hepatitis
- chronic hepatitis
- treatment
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Links
- 206010008909 Chronic Hepatitis Diseases 0.000 title claims abstract description 23
- 208000006454 hepatitis Diseases 0.000 title claims abstract description 18
- 238000002347 injection Methods 0.000 title description 10
- 239000007924 injection Substances 0.000 title description 10
- 239000003814 drug Substances 0.000 claims abstract description 15
- 239000009636 Huang Qi Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 13
- 230000001684 chronic effect Effects 0.000 abstract description 4
- 210000000952 spleen Anatomy 0.000 abstract description 4
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 206010019755 Hepatitis chronic active Diseases 0.000 description 6
- 206010019759 Hepatitis chronic persistent Diseases 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 229960000935 dehydrated alcohol Drugs 0.000 description 4
- 229960004756 ethanol Drugs 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000003908 liver function Effects 0.000 description 3
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 3
- 235000021286 stilbenes Nutrition 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000190633 Cordyceps Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 208000002672 hepatitis B Diseases 0.000 description 2
- 206010019847 hepatosplenomegaly Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010061998 Hepatic lesion Diseases 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000222640 Polyporus Species 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 102000014898 transaminase activity proteins Human genes 0.000 description 1
- 239000005418 vegetable material Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses one kind of Chinese medicine for treating chronic hepatitis and prepared with plant materials. The Chinese medicine is prepared with astragalus root and red sage. The Chinese medicine has the functions of benefiting vital energy, invigorating spleen and promoting blood circulation to disperse blood clots, and thus high curative effect on chronic unresolved and chronic mobile hepatitis.
Description
Technical field
The invention belongs to the pharmaceutical product that derives from vegetable material, is a kind of Chinese medicine injection for the treatment of chronic hepatitis specifically.
Background technology
Chronic hepatitis does not still have therapy preferably so far.Most of patients is told Mental fatigue power and is lacked, is suitable for symptoms such as not good enough, abdominal distention and pain in the hepatic region, and hepatosplenomegaly, liver function are unusual for a long time.Motherland's medical science thinks that it is that damp and hot surplus heresy is residual not most that chronic hepatitis gets pathogenesis, and the liver stasis of blood is insufficiency of the spleen, and insufficiency of vital energy and blood has congestion concurrently.It is strongly fragrant that the poison heresy does not show as the damp and hot stasis of blood to the greatest extent; Healthy energy void shows as insufficiency of the spleen Liver and kidney void, so filter out the Chinese medicine of clearing away heat and eliminating dampness, strengthening the body resistance, blood circulation promoting and blood stasis dispelling, tonifying speen and tonifying kidney from a large amount of Chinese medicines.
Chinese patent 1176123 discloses " a kind of medicine and preparation method for the treatment of chronic hepatitis B ", with Chinese medicine is that feedstock production forms, raw material components mainly is: Herba Hedyotidis Diffusae, Rhizoma Smilacis Glabrae, Cordyceps, Rhizoma Polygoni Cuspidati, Herba Artemisiae Scopariae, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taxilli, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Rhei, Radix Curcumae and other Chinese medicine is totally 18 flavors, makes " three clear hepatitis B capsules ".
Chinese patent 1411835 discloses a kind of " Chinese medicine of treatment chronic hepatitis ", mainly contains the Radix Astragali, Fructus Lycii, Polyporus, gyro wheel, Radix Paeoniae Rubra, the Radix Paeoniae Alba, the Radix Rehmanniae, Rhizoma Paridis, Fructus Ligustri Lucidi, Herba Hedyotidis Diffusae, Cordyceps, Radix Notoginseng, Radix Glehniae, Fructus Jujubae.
Summary of the invention
The invention provides a kind of Chinese medicine injection for the treatment of chronic hepatitis, can reduce the serum glutamic pyruvic transaminase level, alleviate hepatic lesions, raise immunity.
A kind of Chinese medicine injection for the treatment of chronic hepatitis, this compositions is made by following raw materials in weight portion:
Radix Astragali 100-300 part Radix Salviae Miltiorrhizae 50-150 part.
Described compositions is made by following components in weight portions:
100 parts of 200 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali.
Zhi Bei Chinese medicine has the effect of replenishing QI to invigorate the spleen, blood circulation promoting and blood stasis dispelling like this, and total effective rate is respectively 89.5% and 66.7%, the equal highly significant of difference (p＜0.01).The obvious effective rate of chronic active hepatitis is 38.9%, and total effective rate is 69.4%.
Specific implementation method
1. the Radix Astragali 2000 grams decoct three times, and collecting decoction is concentrated into 500 milliliters.Add 500 milliliters of dehydrated alcohol, leave standstill filtration in 24 hours.Reclaim ethanol, be concentrated into paste, add 1500 milliliters of dehydrated alcohol under fully stirring, leave standstill filtration in 24 hours.Add 600 milliliters of waters for injection, add active carbon 0.5 gram decolouring 15 minutes after reclaiming ethanol, filter the back and replenish water for injection to 500 milliliter, transfer pH to 7.0, it is standby to make the sterilization of first liquid.
2. Radix Salviae Miltiorrhizae 1000 grams decoct three times, and collecting decoction is concentrated into 500 milliliters.Adding dehydrated alcohol is 75% to containing the alcohol amount, leaves standstill filtration in 24 hours.Reclaim ethanol, be concentrated into about 350 milliliters, adding dehydrated alcohol to pure content again is 85%, leaves standstill filtration in 24 hours.Add 500 milliliters of waters for injection, reclaim ethanol, get about 400 milliliters of Radix Salviae Miltiorrhizae aqueous solution.Add sodium sulfite 2 grams, active carbon 0.5 gram decolouring 15 minutes is filtered the back and is replenished water for injection to 500 milliliter, transfers pH to 6.8, and it is standby to make the sterilization of second liquid.
3. get equivalent first, second liquid and mix, filter, packing is promptly made the stilbene of the every milliliter of suitable Radix Astragali 2 grams and Radix Salviae Miltiorrhizae 1 gram and is joined injection.
Indication:
Various chronic hepatitiss, outstanding chronic persistent hepatitis, chronic active hepatitis.
Using method:
Stilbene ginseng injection dosage is each 4 milliliters, and drug withdrawal 1 day was treated 6 days in intramuscular injection every day 1 time weekly.Every first quarter moon observes the symptoms, the sign curative effect once, check liver function first quarter moon-January once.Be examples in February 21 course of treatment, the 2-3 months 57 example, the 3-4 months 28 example, the 4-6 months 6 example.
The clinical practice situation:
1. total effects: by shown in the table 1, the obvious effective rate of chronic persistent hepatitis treatment group and matched group is respectively 80.3% promptly 44.4%, and total effective rate is respectively 89.5% and 66.7%, the equal highly significant of difference (p＜0.01).The obvious effective rate of chronic active hepatitis is 38.9%, and total effective rate is 69.4%.
The curative effect of table 1 chronic hepatitis 112 examples
The total effectively p of type treatment produce effects enabledisable produce effects
Example numerical example numerical example numerical example is counted % %
Chronic persistent
Treatment organizes 76 61 78 80.3 89.5＜0.01
Matched group 36 16 8 12 44.4 66.7
Chronic active 36 14 11 11 38.9 69.4
2. symptom, sign curative effect: the most of patients doing well,improving, to the effective percentage of inappetence, weak, abdominal distention and four cardinal symptoms of pain in the hepatic region respectively 86.9,80.2,68.7,51.1.Patient's hepatosplenomegaly of about 1/4 takes a turn for the better in the chronic persistent hepatitis.
3. liver function curative effect: the curative effect of low ebb-pyruvic transaminase is better, and in 112 examples, 78 examples recover normal, and 13 examples take a turn for the better, effective percentage 81.2%, wherein 81.3% (74/91) case in treatment 1-2 after the month glutamate pyruvate transaminase promptly take a turn for the better or recover normal.To chronic persistent hepatitis fall the enzyme curative effect than chronic active hepatitis for well, 61 examples recover normal in the former 76 examples, 7 examples take a turn for the better effective percentage 89.5%; 17 examples recover normal in the latter's 36 examples, and 6 examples take a turn for the better effective percentage 63.9% (p＜0.05).Icteric index slightly increases and is 12-15 before the treatment of 3 routine chronic active hepatitiss, all recovers normal after the treatment.
4. follow-up observation: treatment is obtained chronic persistent hepatitis 59 examples and the chronic active hepatitis 18 routine patients of effect, follow-up observation March-1 year after the drug withdrawal, stable disease person's 54 examples (701%) as a result; The state of an illness has fluctuation slightly, and glutamate pyruvate transaminase increases and is no more than 80 persons of unit, 10 examples (130%); The state of an illness belongs to " knock-on " person 13 examples (169%) before returning back to treatment.The 11 routine reuse stilbene ginseng injection for treating 2-3 months in " knock-on " case, 10 examples obtain effect again as a result, and 1 example is invalid.
Claims (2)
1. a Chinese medicine for the treatment of chronic hepatitis is characterized in that the present invention is by following
Components in weight portions is made:
Radix Astragali 100-300 part Radix Salviae Miltiorrhizae 50-150 part.
2. compositions according to claim 1 is characterized in that this Chinese medicine makes by following components in weight portions:
100 parts of 200 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310107087 CN1621062A (en) | 2003-11-24 | 2003-11-24 | Chinese traditional medicinal injection for treating chronic hepatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310107087 CN1621062A (en) | 2003-11-24 | 2003-11-24 | Chinese traditional medicinal injection for treating chronic hepatitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1621062A true CN1621062A (en) | 2005-06-01 |
Family
ID=34757962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310107087 Pending CN1621062A (en) | 2003-11-24 | 2003-11-24 | Chinese traditional medicinal injection for treating chronic hepatitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1621062A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973660A (en) * | 2011-09-06 | 2013-03-20 | 江中药业股份有限公司 | Chronic hepatitis treatment traditional Chinese medicine composition and preparation method thereof |
| CN107050381A (en) * | 2017-02-24 | 2017-08-18 | 中国人民解放军第三0二医院 | A kind of Chinese medicine composition for treating chronic hepatitis, its granule and preparation method |
-
2003
- 2003-11-24 CN CN 200310107087 patent/CN1621062A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973660A (en) * | 2011-09-06 | 2013-03-20 | 江中药业股份有限公司 | Chronic hepatitis treatment traditional Chinese medicine composition and preparation method thereof |
| CN102973660B (en) * | 2011-09-06 | 2014-10-15 | 江中药业股份有限公司 | Chronic hepatitis treatment traditional Chinese medicine composition and preparation method thereof |
| CN107050381A (en) * | 2017-02-24 | 2017-08-18 | 中国人民解放军第三0二医院 | A kind of Chinese medicine composition for treating chronic hepatitis, its granule and preparation method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |